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https://www.readbyqxmd.com/read/28935570/molecular-alterations-in-a-mouse-cardiac-model-of-friedreich-s-ataxia-an-impaired-nrf2-response-mediated-via-up-regulation-of-keap1-and-activation-of-the-gsk3%C3%AE-axis
#1
Amy Anzovino, Shannon Chiang, Bronwyn E Brown, Clare L Hawkins, Des R Richardson, Michael L-H Huang
Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a master regulator of the anti-oxidant response. However, studies in models of Friedreich's ataxia (FA), a neuro- and cardio-degenerative disease associated with oxidative stress, reported decreased Nrf2 expression due to unknown mechanisms. Using a mouse conditional frataxin knockout (KO) model in the heart and skeletal muscle, we examined the Nrf2 pathway in these tissues. Frataxin KO results in fatal cardiomyopathy, while skeletal muscle was asymptomatic...
September 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28933604/the-nottingham-fatigue-after-stroke-notfast-study-factors-associated-with-severity-of-fatigue-in-stroke-patients-without-depression
#2
Avril Drummond, Louise Hawkins, Nikola Sprigg, Nick S Ward, Amit Mistri, Pippa Tyrrell, Gillian E Mead, Esme Worthington, Nadina B Lincoln
OBJECTIVE: To identify factors associated with post-stroke fatigue in a sample of stroke survivors without depression. DESIGN: Cross-sectional cohort study. SETTING: Recruitment was from four stroke units in the UK. SUBJECTS: Participants were assessed within four to six weeks of first stroke; those with high levels of depressive symptoms (score ⩾7 Brief Assessment Schedule Depression Cards) were excluded. MAIN MEASURES: Participants were assessed after stroke on the Fatigue Severity Scale of the Fatigue Assessment Inventory, the Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Beck Anxiety Index, Sleep Hygiene Index, 6m walk test, and measures of cognitive ability...
October 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28932766/poststroke-trajectories-the-process-of-recovery-over-the-longer-term-following-stroke
#3
Rebecca J Hawkins, Adam Jowett, Mary Godfrey, Kirste Mellish, John Young, Amanda Farrin, Ivana Holloway, Jenny Hewison, Anne Forster
We adopted a grounded theory approach to explore the process of recovery experienced by stroke survivors over the longer term who were living in the community in the United Kingdom, and the interacting factors that are understood to have shaped their recovery trajectories. We used a combination of qualitative methods. From the accounts of 22 purposively sampled stroke survivors, four different recovery trajectories were evident: (a) meaningful recovery, (b) cycles of recovery and decline, (c) ongoing disruption, (d) gradual, ongoing decline...
January 2017: Global Qualitative Nursing Research
https://www.readbyqxmd.com/read/28930665/tissue-resident-macrophages-in-pancreatic-ductal-adenocarcinoma-originate-from-embryonic-hematopoiesis-and-promote-tumor-progression
#4
Yu Zhu, John M Herndon, Dorothy K Sojka, Ki-Wook Kim, Brett L Knolhoff, Chong Zuo, Darren R Cullinan, Jingqin Luo, Audrey R Bearden, Kory J Lavine, Wayne M Yokoyama, William G Hawkins, Ryan C Fields, Gwendalyn J Randolph, David G DeNardo
No abstract text is available yet for this article.
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28922091/how-cancer-patients-use-and-benefit-from-an-interactive-cancer-communication-system
#5
Jeong Yeob Han, Robert Hawkins, Timothy Baker, Dhavan V Shah, Suzanne Pingree, David H Gustafson
Despite the mounting evidence of efficacy of eHealth interventions, their mechanisms of action remain unknown. The current study analyzed patient log data as each patient engaged in an eHealth system called the Comprehensive Health Enhancement Support System (CHESS) and reports on how patients engage with different combinations of eHealth services over time. Newly diagnosed breast cancer patients (N = 443) were given access for 6 months to one of four different configurations of CHESS: (1) Information, (2) Information and Support, (3) Information, Support, and Coaching (Full CHESS), and (4) Full CHESS and Mentor...
September 18, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28920456/child-sexual-abuse-prevention-opportunities-parenting-programs-and-the-reduction-of-risk
#6
Julia Rudolph, Melanie J Zimmer-Gembeck, Dianne C Shanley, Russell Hawkins
To date, child sexual abuse (CSA) prevention has relied largely on child-focused education, teaching children how to identify, avoid, and disclose sexual abuse. The purpose of this article is to explore how prevention opportunities can include parents in new and innovative ways. We propose that parents can play a significant role as protectors of their children via two pathways: (i) directly, through the strong external barriers afforded by parent supervision, monitoring, and involvement; and (ii) indirectly, by promoting their children's self-efficacy, competence, well-being, and self-esteem, which the balance of evidence suggests will help them become less likely targets for abuse and more able to respond appropriately and disclose abuse if it occurs...
January 1, 2017: Child Maltreatment
https://www.readbyqxmd.com/read/28919513/accompanying-indigenous-maya-patients-with-complex-medical-needs-a-patient-navigation-system-in-rural-guatemala
#7
Anita Chary, David Flood, Kirsten Austad, Marcela Colom, Jessica Hawkins, Katia Cnop, Boris Martinez, Waleska Lopez, Peter Rohloff
No abstract text is available yet for this article.
September 14, 2017: Healthcare
https://www.readbyqxmd.com/read/28919184/clinical-significance-of-failure-to-lose-weight-10-years-after-roux-en-y-gastric-bypass
#8
Robert B Hawkins, J Hunter Mehaffey, Timothy L McMurry, Jennifer Kirby, Steven K Malin, Bruce Schirmer, Peter T Hallowell
BACKGROUND: Although Roux-en-Y gastric bypass (RYGB) induces short-term weight loss and co-morbidity amelioration, long-term data suggest that a subset of patients return to their preoperative body mass index (BMI). OBJECTIVES: To identify the clinical implications of 10-year weight loss failure after RYGB. SETTING: An academic teaching hospital. METHODS: Adults undergoing RYGB (1985-2004) were included in this study (n = 1087)...
August 9, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28916216/coronary-artery-bypass-grafting-bundled-payment-proposal-will-have-significant-financial-impact-on-hospitals
#9
Robert B Hawkins, J Hunter Mehaffey, Kenan W Yount, Leora T Yarboro, Clifford Fonner, Irving L Kron, Mohammed Quader, Alan Speir, Jeffrey Rich, Gorav Ailawadi
OBJECTIVES: The Centers for Medicare and Medicaid Services plans to institute a 5-year trial of bundled payments for coronary artery bypass grafting through 90 days after discharge. To investigate the impact, we reviewed actual inpatient costs for patients undergoing bypass surgery relative to the target price. METHODS: A total of 13,276 Medicare patients with estimated cost data underwent isolated coronary artery bypass grafting from 2008 to 2015 in 18 hospitals over 8 Medicare-defined regions within the Commonwealth of Virginia...
July 29, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28914899/tapered-polysilicon-core-fibers-for-nonlinear-photonics-erratum
#10
Fariza H Suhailin, Li Shen, Noel Healy, Limin Xiao, Maxwell Jones, Thomas Hawkins, John Ballato, Ursula J Gibson, Anna C Peacock
We correct an error of the nonlinear refractive index used in our original paper.
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28914259/epigenetic-targeting-of-notch1-driven-transcription-using-the-hdaci-panobinostat-is-a-potential-therapy-against-t-cell-acute-lymphoblastic-leukemia
#11
M Waibel, S J Vervoort, I Y Kong, S Heinzel, K M Ramsbottom, B P Martin, E D Hawkins, R W Johnstone
Leukemia accepted article preview online, 15 September 2017. doi:10.1038/leu.2017.282.
September 15, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28905276/causal-explanation-improves-judgment-under-uncertainty-but-rarely-in-a-bayesian-way
#12
Brett K Hayes, Jeremy Ngo, Guy E Hawkins, Ben R Newell
Three studies reexamined the claim that clarifying the causal origin of key statistics can increase normative performance on Bayesian problems involving judgment under uncertainty. Experiments 1 and 2 found that causal explanation did not increase the rate of normative solutions. However, certain types of causal explanation did lead to a reduction in the magnitude of errors in probability estimation. This effect was most pronounced when problem statistics were expressed in percentage formats. Experiment 3 used process-tracing methods to examine the impact of causal explanation of false positives on solution strategies...
September 13, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28904952/internal-impingement-of-the-shoulder-a-risk-of-false-positive-test-outcomes-in-external-impingement-tests
#13
Tim Leschinger, Christopher Wallraff, Dirk Müller, Matthias Hackenbroch, Henning Bovenschulte, Jan Siewe
BACKGROUND: External impingement tests are considered as being particularly reliable for identifying subacromial and coracoid shoulder impingement mechanisms. The purpose of the present study was to evaluate if these tests are likely to provoke an internal shoulder impingement mechanism which, in cases of a pathologic condition, can lead to a positive test result. METHOD: In 37 subjects, the mechanical contact between the glenoid rim and the rotator cuff (RC) was measured quantitatively and qualitatively in external impingement test positions using an open MRI system...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904196/vaccinia-virus-encodes-a-novel-inhibitor-of-apoptosis-that-associates-with-the-apoptosome
#14
Melissa R Ryerson, Monique M Richards, Marc Kvansakul, Christine J Hawkins, Joanna L Shisler
Apoptosis is an important anti-viral host defense mechanism. Here we report the identification of a novel apoptosis inhibitor encoded by the vaccinia virus (VACV) M1L gene. M1L is absent in the attenuated MVA strain of VACV, a strain that stimulates apoptosis in several types of immune cells. M1 expression increased the viability of MVA-infected THP-1 and Jurkat cells and reduced several biochemical hallmarks of apoptosis such as PARP-1 and procaspase-3 cleavage. Furthermore, ectopic M1L expression decreased staurosporine-induced (intrinsic) apoptosis in HeLa cells...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28899256/the-experience-of-feeling-disrespected-a-humanbecoming-perspective
#15
Kim Hawkins
The concept of feeling disrespected was explored using the Parse research method. Ten women living with embodied largeness were asked, "What is the experience of feeling disrespected?" The structure of the living experience was feeling disrespected is mortifying disheartenment arising with disquieting irreverence, as distancing affiliations surface while enduring hardship. The findings provided new knowledge of living quality, advanced nursing practice, and presented future direction for research.
April 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28891760/the-nottingham-fatigue-after-stroke-notfast-study-results-from-follow-up-six-months-after-stroke
#16
Louise Hawkins, Nadina B Lincoln, Nikola Sprigg, Nick S Ward, Amit Mistri, Pippa Tyrrell, Esme Worthington, Avril Drummond
Background Post-stroke fatigue is common and disabling. Objectives The aim of NotFAST was to examine factors associated with fatigue in stroke survivors without depression, six months after stroke. Methods Participants were recruited from four UK stroke units. Those with high levels of depressive symptoms (score ≥7 on Brief Assessment Schedule Depression Cards) or aphasia were excluded. Follow-up assessment was conducted at six months after stroke. They were assessed on the Fatigue Severity Scale, Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Barthel Index, Beck Anxiety Index, Brief Assessment Schedule Depression Cards, Impact of Event Scale-Revised, and Sleep Hygiene Index...
September 11, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28890158/childhood-cancer-the-long-term-costs-of-cure
#17
Miranda M Fidler, Michael M Hawkins
No abstract text is available yet for this article.
September 7, 2017: Lancet
https://www.readbyqxmd.com/read/28890062/national-utilization-and-outcomes-of-redo-lower-extremity-bypass-vs-endovascular-intervention-after-previous-failed-bypass-redo-lower-extremity-bypass-superior-to-endovascular-intervention
#18
J Hunter Mehaffey, Alexander Shannon, Robert B Hawkins, Anna Fashandi, Margret C Tracci, Irving L Kron, Gilbert R Upchurch, William P Robinson
BACKGROUND: Redo Lower extremity bypass (LEB) and infrainguinal endovascular intervention (IEI) are options to treat critical limb ischemia after a failed prior lower extremity bypass but the utilization and outcomes of each are poorly described. The purpose of this study was to compare 30-day Major Adverse Limb Events (MALE) and Major Adverse Cardiovascular Events (MACE) after LEB and IEI in patients with a failed prior ipsilateral LEB and determine risk factors for each composite outcome...
September 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28878857/unusual-soft-tissue-uptake-of-f-18-sodium-fluoride-in-three-patients-undergoing-f-18-naf-pet-ct-bone-scans-for-prostate-cancer
#19
Andrew S Hawkins, Brandon A Howard
Three males aged 71 to 80 years with known stage IV metastatic prostate cancer underwent F-18 sodium fluoride (NaF) PET/CT to assess osseous metastatic disease burden and stability. In addition to F-18 NaF avid known osseous metastases, each patient also exhibited increased F-18 NaF activity in soft tissues. The first patient exhibited multiple F-18 NaF avid enlarged retroperitoneal and pelvic lymph nodes on consecutive PET/CT scans. The second patient demonstrated an F-18 NaF avid thyroid nodule on consecutive PET/CT scans...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28871850/succinoglycan-production-contributes-to-acidic-ph-tolerance-in-sinorhizobium-meliloti-rm1021
#20
Justin P Hawkins, Barney A Geddes, Ivan John Oresnik
In this work, the hypothesis that exopolysaccharide plays a role in the survival of S. meliloti at low pH is addressed. When S. meliloti was grown at pH 5.75 the synthesis of succinoglycan increased, whereas the synthesis of galactoglucan decreased. Succinoglycan that was isolated from cultures grown at low pH had a lower degree of polymerization relative to that which was isolated from cultures grown at neutral pH, suggesting that low molecular weight (LMW) succinoglycan might play a role in adaptation to low pH...
September 5, 2017: Molecular Plant-microbe Interactions: MPMI
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