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https://www.readbyqxmd.com/read/28931163/influence-of-quercetin-in-the-temporal-regulation-of-redox-homeostasis-in-drosophila-melanogaster
#1
Perumal Subramanian, Kanimozhi Kaliyamoorthy, Jaime Jacqueline Jayapalan, Puteri Shafinaz Abdul-Rahman, Onn Haji Hashim
Numerous biological processes are governed by the biological clock. Studies using Drosophila melanogaster (L.) are valuable that could be of importance for their effective applications on rodent studies. In this study, the beneficial role of quercetin (a flavonoid) on H2O2 induced stress in D. melanogaster was investigated. D. melanogaster flies were divided into four groups (group I - control, group II - H2O2 (acute exposure), group III - quercetin, and group IV - quercetin + H2O2 treated). Negative geotaxis assay, oxidative stress indicators (protein carbonyls, thiobarbituric reactive substances [TBARS]), and antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione-S-transferase [GST], glutathione peroxidase, and reduced glutathione [GSH]) were measured at 4 h intervals over 24 h and temporal expression of heat shock protein-70 (Hsp70), Upd1 (homolog of IL-6 in Drosophila), and nitric oxide synthase (Nos) was analyzed by Western blotting...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28931056/heterogeneity-in-the-expression-and-subcellular-localization-of-polyol-monosaccharide-transporter-genes-in-lotus-japonicus
#2
Lu Tian, Leru Liu, Yehu Yin, Mingchao Huang, Yanbo Chen, Xinlan Xu, Pingzhi Wu, Meiru Li, Guojiang Wu, Huawu Jiang, Yaping Chen
Polyols can serve as a means for the translocation of carbon skeletons and energy between source and sink organs as well as being osmoprotective solutes and antioxidants which may be involved in the resistance of some plants to biotic and abiotic stresses. Polyol/Monosaccharide transporter (PLT) proteins previously identified in plants are involved in the loading of polyols into the phloem and are reported to be located in the plasma membrane. The functions of PLT proteins in leguminous plants are not yet clear...
2017: PloS One
https://www.readbyqxmd.com/read/28930667/phenylpropanoid-profiling-reveals-a-class-of-hydroxycinnamoyl-glucaric-acid-conjugates-in-isatis-tinctoria-leaves
#3
Thi-Kieu-Oanh Nguyen, Arash Jamali, Eric Grand, Kris Morreel, Paulo Marcelo, Eric Gontier, Rebecca Dauwe
The brassicaceous herb, Isatis tinctoria, is an ancient medicinal plant whose rosette leaf extracts have anti-inflammatory and anti-allergic activity. Brassicaceae are known to accumulate a variety of phenylpropanoids in their rosette leaves acting as antioxidants and a UV-B shield, and these compounds often have pharmacological potential. Nevertheless, knowledge about the phenylpropanoid content of I. tinctoria leaves remains limited to the characterization of a number of flavonoids. In this research, we profiled the methanol extracts of I...
September 17, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28930620/effects-and-mechanisms-of-actions-of-phytochemicals-on-alzheimer-s-disease-neuropathology
#4
Richard E Hartman, David M Ross
Alzheimer's disease affects millions of people, yet, there are only a limited number approaches for it pharmacological treatment. Thus, identifying factors that decrease the risk of developing Alzheimer's disease is of paramount importance. A growing body of epidemiological and experimental evidence suggests that dietary fruits and vegetables have neuroprotective effects against the harmful effects of oxidative stress, neuroinflammation, and aging. These effects are mediated by various phytochemical compounds found in plants that exhibit antioxidant, anti-inflammatory, and other beneficial properties...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930619/asiatic-acid-nullified-aluminium-toxicity-in-in-vitro-model-of-alzheimer-s-disease
#5
Mashoque Ahmad Rather, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Jegadeesan Nataraj, Musthafa Mohamed Essa, Saravana Babu Chidambaram
Aluminium (Al) is a ubiquitously distributed environmental toxicant that lacks biological functions; however, its accumulation in the brain has been demonstrated to be linked to several neuropathological conditions particularly Alzheimer's disease (AD). Asiatic acid (AA), a triterpene extracted from Centella asiatica, has been reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. The present study was aimed to explore the neuroprotective effect of AA against aluminium maltolate (Al(mal)3) induced neurotoxicity by assessing cell viability, mitochondrial membrane potential, levels of reactive oxygen species (ROS), DNA damage and apoptosis (Hoechst and dual staining, comet assay; expressions of pro-apoptotic, anti-apoptotic and signaling indices) via AKT/GSK-3β signaling pathway in SH-SY 5Y  neuroblastoma cells...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930576/impact-of-chocolate-on-the-cardiovascular-health
#6
Maria Alessandra Gammone, Konstantinos Efthymakis, Francesca Romana Pluchinotta, Sonia Bergante, Guido Tettamanti, Graziano Riccioni, Nicolantonio D'Orazio
The antioxidants such as polyphenols, especially flavonols, present in large quantitites in cocoa, cause vasodilation, modulate inflammatory markers and cardiovascular health, and possess a range of protective cardiovascular effects. On the other hand, overconsumption of chocolate can lead to tachyarrhythmias, supraventricular tachycardia, atrial fibrillation, ventricular tachycardia and ventricular fibrillation due to its caffeine content. This review describes both the cardioprotective and adverse effects of chocolate and its constituents...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930528/biotechnological-improvement-of-nutritional-and-therapeutic-value-of-cultivated-potato
#7
Deepak Singh Bagri, Devanshi Chandel Upadhyay, Subodh Kumar Jain, Chandrama Prakash Upadhyay
Genetic engineering is recognized as a powerful tool for altering the genetic characteristic of crop plants. Genetic engineering has tremendous potential in developing improved potato varieties with desired agronomic traits and has been utilized for improvement of several crop plants including potato to enhance essential amino acid, protein and lipids/carbohydrates contents as well to improve stress tolerance. The pathway engineering of amino acid revealed dramatic changes in essential amino acid content and protein quality...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28930281/the-genus-artemisia-a-2012-2017-literature-review-on-chemical-composition-antimicrobial-insecticidal-and-antioxidant-activities-of-essential-oils
#8
REVIEW
Abhay K Pandey, Pooja Singh
Essential oils of aromatic and medicinal plants generally have a diverse range of activities because they possess several active constituents that work through several modes of action. The genus Artemisia includes the largest genus of family Asteraceae has several medicinal uses in human and plant diseases aliments. Extensive investigations on essential oil composition, antimicrobial, insecticidal and antioxidant studies have been conducted for various species of this genus. In this review, we have compiled data of recent literature (2012-2017) on essential oil composition, antimicrobial, insecticidal and antioxidant activities of different species of the genus Artemisia...
September 12, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930279/comparative-evaluation-of-oxidative-stress-modulating-and-dna-protective-activities-of-aqueous-and-methanolic-extracts-of-acacia-catechu
#9
Ashwini Patil, Manisha Modak
Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as water soluble compounds would be more beneficial with respect to certification, safety and commercial issues. Oxidative stress is involved in development of many diseases; therefore, antioxidants are now being looked upon as convincing therapeutics against such diseases...
September 5, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930277/biological-activities-of-three-essential-oils-of-the-lamiaceae-family
#10
REVIEW
Gema Nieto
Herbs and spices have been used since ancient times to improve the sensory characteristics of food, to act as preservatives and for their nutritional and healthy properties. Herbs and spices are generally recognized as safe (GRAS) and are excellent substitutes for chemical additives. Essential oils are mixtures of volatile compounds obtained, mainly by steam distillation, from medicinal and aromatic plants. They are an alternative to synthetic additives for the food industry, and they have gained attention as potential sources for natural food preservatives due to the growing interest in the development of safe, effective, natural food preservation...
August 23, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930275/anti-aging-and-antioxidant-potential-of-paullinia-cupana-var-sorbilis-findings-in-caenorhabditis-elegans-indicate-a-new-utilization-for-roasted-seeds-of-guarana
#11
Herbenya Peixoto, Mariana Roxo, Teresa Röhrig, Elke Richling, Xiaojuan Wang, Michael Wink
Background: Roasted seeds of Amazonian guarana (Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich in purine alkaloids, markedly caffeine, the seeds are extensively used in the Brazilian beverage industry for the preparation of soft drinks and as additives in energy drinks. Methods: To investigate the putative anti-aging and antioxidant activity of guarana, we used the model organism Caenorhabditis elegans. Chemical analyses were performed using high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS/MS)...
August 15, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930269/chemical-composition-antifungal-and-antioxidant-activities-of-hedyosmum-brasiliense-mart-ex-miq-chloranthaceae-essential-oils
#12
Cynthia Murakami, Inês Cordeiro, Marcus Tullius Scotti, Paulo Roberto H Moreno, Maria Cláudia M Young
Background: Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) is a dioecious shrub popularly used in Brazil to treat foot fungi and rheumatism. This work investigated the chemical composition, antifungal, and antioxidant activities of flowers and leaves of H. brasiliense essential oils; Methods: H. brasiliense male and female flowers and leaves were collected at Ilha do Cardoso (São Paulo) and the essential oils were extracted by hydrodistillation and analyzed by GC/MS and their similarity compared by Principal Component Analysis...
July 17, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930268/antioxidant-activity-of-essential-oil-extracted-by-sc-co%C3%A2-from-seeds-of-trachyspermum-ammi
#13
Aarti Singh, Anees Ahmad
Bcakground: Extracts obtained from natural sources such as plants are of immense importance for humans. Methods: Therefore this study was conducted to obtain essential oil from the seeds of T. ammi by conventional and non-conventional methods. Hydrodistillation (HD), Solvent Extraction (SE), Ultrasonication (US), and Supercritical Carbon-dioxide (SC-CO₂) extraction techniques were used to extract essential oil from the powdered seeds of T. ammi. A quality control method for each extracted oil was developed using HPTLC, FTIR, and GC-MS...
July 11, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930267/%C3%AE-selinene-rich-essential-oils-from-the-parts-of-callicarpa-macrophylla-and-their-antioxidant-and-pharmacological-activities
#14
Mahesh Chandra, Om Prakash, Ravendra Kumar, Rakesh Kumar Bachheti, Brij Bhushan, Mahesh Kumar, Anil Kumar Pant
Background:Callicarpa macrophylla (Varbenaceae) is a medicinal shrub and is traditionally used in India, China, and South Asia. Methods: The plant material was collected from lower Himalayan region of Uttarakhand in India. The essential oils from three different aerial parts were analyzed by GC-MS. Antioxidant activity, phenolic assay, and various pharmacological activities were determined by using existing methods which are generally practiced widely. Results: Over 51, 53, and 40 compounds were identified in C...
July 10, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930266/chemical-composition-of-four-essential-oils-of-eugenia-from-the-brazilian-amazon-and-their-cytotoxic-and-antioxidant-activity
#15
Joyce Kelly R da Silva, Eloisa Helena A Andrade, Leilane H Barreto, Nádia Carolina F da Silva, Alcy F Ribeiro, Raquel C Montenegro, José Guilherme S Maia
Background:Eugenia species are appreciated for their edible fruits and are known as having anticonvulsant, antimicrobial and insecticidal actions. Methods: The plant material was collected in the southeastern Pará state of Brazil and submitted to hydrodistillation. GC-MS analyzed the oils, and their antioxidant and cytotoxic activities were evaluated by the DPPH and MTT assays. Results: The main components identified in the Eugenia oils were 5-hydroxy-cis-calemene, (2E,6E)-farnesol, (2E,6Z)-farnesol, caryophylla-4(12),8(13)-dien-5α-ol-5β-ol, E-γ-bisabolene, β-bisabolene, germacrene D, and ishwarane...
July 8, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930257/physicochemical-properties-antioxidant-and-cytotoxic-activities-of-crude-extracts-and-fractions-from-phyllanthus-amarus
#16
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lower levels of residual moisture (7.40%) and water activity (0.24) and higher contents of saponins, phenolics, flavonoids, and proanthocyanidins (1657...
June 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930254/synthesis-antimicrobial-and-antioxidant-activities-of-chalcogen-containing-nitrone-derivatives-from-r-citronellal
#17
Mariana C Ferraz, Renata A Mano, Daniela H Oliveira, Darla S V Maia, Wladimir P Silva, Lucielli Savegnago, Eder J Lenardão, Raquel G Jacob
Background: The main constituents of Cymbopogonnardus (L) Rendle and C. citratus (DC) Stapfessential oils are (R)-citronellal and citral, respectively. Organochalcogen compounds can boost the biological activities of natural products. Methods: Several chalcogen-containing nitrones derived from (R)-citronellal and citral were prepared and evaluated for their antimicrobial and antioxidant activities. The antimicrobial activity was evaluated by the disc diffusion test and the antioxidant properties were evaluated in vitro by DPPH (1,1-diphenyl-2-picryl-hydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and FRAP (ferric ion reducing antioxidant power) assays...
June 10, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930251/chemical-profiling-and-evaluation-of-antioxidant-and-anti-microbial-properties-of-selected-commercial-essential-oils-a-comparative-study
#18
Ângelo Luís, Ana Paula Duarte, Luísa Pereira, Fernanda Domingues
Background: The last decades have seen an increased awareness by the scientific community of the extent of resistance to conventional antibiotics, particularly with respect to the emerging multidrug-resistant pathogenic microbes. Additionally, natural antioxidants have received significant attention among food professionals and consumers because of their assumed safety and potential therapeutic value. The aim of this work was to assess the antioxidant activities of eight selected commercial essential oils (EOs), together with the evaluation of their antibacterial and anti-quorum sensing properties...
June 5, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930249/anti-inflammatory-antioxidant-antibiotic-and-cytotoxic-activities-of-tanacetum-vulgare-l-essential-oil-and-its-constituents
#19
Héloïse Coté, Marie-Anne Boucher, André Pichette, Jean Legault
Background:Tanacetum vulgare L. (Asteraceae) is a perennial herb that has been used to treat multiple ailments. Regional variability of the chemical composition of T. vulgare essential oils is well-known. Despite these regional chemotypes, most relevant studies did not analyze the complete chemical composition of the T. vulgare essential oil and its constituents in relation to their biological activities. Here, we assess the anti-inflammatory, antioxidant, antibacterial, and cytotoxic activities of T. vulgare collected from northern Quebec (Saguenay-Lac-St-Jean), Canada...
May 25, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930245/antioxidant-and-antimicrobial-activities-of-the-essential-oil-of-achillea-millefolium-l-grown-in-france
#20
Chaker El-Kalamouni, Petras Rimantas Venskutonis, Bachar Zebib, Othmane Merah, Christine Raynaud, Thierry Talou
Background: This study aimed to examine the composition of essential oil (EO) of A. millefolium aerial parts wild plant grown in France and evaluate its antioxidant, antibacterial, and antifungal activities. Methods: GC-MS was used to identify the chemical composition of EO. Antioxidant activity (AA) of EO was evaluated by Oxipres method. Antimicrobial activity of EO was evaluated by Agar-well diffusion and a broth microdilution assay. Results: Forty-three volatile compounds were identified. Major compounds were camphor (12...
May 19, 2017: Medicines (Basel, Switzerland)
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