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https://www.readbyqxmd.com/read/27936457/genetic-disruption-of-nrf2-promotes-the-development-of-necroinflammation-and-liver-fibrosis-in-a-mouse-model-of-hfe-hereditary-hemochromatosis
#1
Tiago L Duarte, Carolina Caldas, Ana G Santos, Sandro Silva-Gomes, Andreia Santos-Gonçalves, Maria João Martins, Graça Porto, José Manuel Lopes
BACKGROUND AND AIMS: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor NRF2 is a critical determinant of hepatocyte viability during exposure to acute dietary iron overload...
December 1, 2016: Redox Biology
https://www.readbyqxmd.com/read/27936436/spectroscopic-single-crystal-x-ray-hirshfeld-in-vitro-and-in-silico-biological-evaluation-of-a-new-series-of-potent-thiazole-nucleus-integrated-with-pyrazoline-scaffolds
#2
Vinutha V Salian, Badiadka Narayana, Balladka K Sarojini, Madan S Kumar, Govinahalli S Nagananda, Kullaiah Byrappa, Avinash K Kudva
In the present study, the spectroscopic characterization of a new series of substituted thiazole linked pyrazoline scaffolds 4a-l was performed. The formation of 4a-l from the intermediate 3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazole-1-carbothioamide 2 and substituted 2-bromo-1-phenylethanone 3a-l was evidenced through the changes in FTIR, (1)H NMR, (13)C NMR, LCMS data. The X-ray diffraction studies revealed that compound 2 and 4g crystallized in monoclinic crystal system with P21/n space group...
November 28, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27936340/high-morning-blood-pressure-surge-is-associated-with-oxidative-stress-and-paraoxonase-1-activity-in-newly-diagnosed-hypertensive-patients
#3
Onur Kaypaklı, Mustafa Gür, Hazar Harbalıoğlu, Taner Şeker, Şahabettin Selek
BACKGROUND: Both oxidative stress and morning surge (MS) of blood pressure (BP) were found to be closely related with cardiovascular and cerebrovascular diseases. We investigated the association between MS of BP and oxidative stress in newly diagnosed hypertensive patients. METHODS: We prospectively included 237 newly diagnosed hypertensive patients in the present study (mean age: 51.6 ± 11.7 years). The patients were classified according to the extent of the sleep-through surge as follows: the top decile of sleep-through surge (>47...
December 9, 2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27936335/rac2-p38-mapk-dependent-nadph-oxidase-activity-is-associated-with-the-resistance-of-quiescent-cells-to-ionizing-radiation
#4
Hailong Pei, Jian Zhang, Jing Nie, Nan Ding, Wentao Hu, Junrui Hua, Ryoichi Hirayama, Yoshiya Furusawa, Cuihua Liu, Bingyan Li, Tom K Hei, Guangming Zhou
Our recent study showed that quiescent G0 cells are more resistant to ionizing radiation than G1 cells; however, the underlying mechanism for this increased radioresistance is unknown. Based on the relatively lower DNA damage induced in G0 cells, we hypothesize that these cells are exposed to less oxidative stress during exposure. As a catalytic subunit of NADPH oxidase, Ras-related C3 botulinum toxin substrate 2 (RAC2) may be involved in the cellular response to ionizing radiation. Here, we show that RAC2 was expressed at low levels in G0 cells but increased substantially in G1 cells...
December 9, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27936316/bioprospecting-of-turbinaria-macroalgae-as-a-potential-source-of-health-protective-compounds
#5
Milena Stranska-Zachariasova, Isma Kurniatanty, Helena Gbelcova, Monika Jiru, Josep Rubert, Tjokorda Gde Tirta Nindhia, Cosimo Walter D'Acunto, Sony Heru Sumarsono, Marselina Irasonia Tan, Jana Hajslova, Tomas Ruml
The present study aims to focus on the bioprospecting of marine macroalgae of Turbinaria species, plenteous biomass of the world ocean. Three types of solvents, i.e. water, methanol:water (80:20, v/v) and hexane:isopropanol (50:50, v/v), were used for extraction. Both the biological activity, as well as the pattern of present chemicals were characterized. For the cell proliferation assay, the human embryonic kidney 293 cells, cervix / breast / pancreatic adenocarcinoma, and osteosarcoma cells were used. For the antioxidant activity determination, both intracellular assay with human embryonic kidney and cervix adenocarcinoma cells, as well as the biochemical DPPH test, were employed...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936295/variability-of-pinus-halepensis-mill-essential-oils-and-their-antioxidant-activities-depending-on-the-stage-of-growth-during-vegetative-cycle
#6
Zineb Djerrad, Abderrahmane Djouahri, Leila Kadik
The impact of growth stages during vegetative cycle (B0 -B5 ) on chemical composition and antioxidant activities of Pinus halepensis Mill. needles essential oils was investigated for the first time. GC and GC-MS analyses pointed to a quantitative variability of components; terpene hydrocarbons derivatives, represented by α-pinene (8.5-12.9%), myrcene (17.5-21.6%), p-cymene (7.9-11.9%) and (Z)-β-caryophyllene (17.3-21.2%) as major components, decreased from 88.9% at B0 growth stage to 66.9% at B5 growth stage, whereas oxygenated derivatives, represented by caryophyllene oxide (5...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936081/comparative-analysis-of-fruit-metabolites-and-pungency-candidate-genes-expression-between-bhut-jolokia-and-other-capsicum-species
#7
Sarpras M, Rashmi Gaur, Vineet Sharma, Sushil Satish Chhapekar, Jharna Das, Ajay Kumar, Satish Kumar Yadava, Mukesh Nitin, Vijaya Brahma, Suresh K Abraham, Nirala Ramchiary
Bhut jolokia, commonly known as Ghost chili, a native Capsicum species found in North East India was recorded as the naturally occurring hottest chili in the world by the Guinness Book of World Records in 2006. Although few studies have reported variation in pungency content of this particular species, no study till date has reported detailed expression analysis of candidate genes involved in capsaicinoids (pungency) biosynthesis pathway and other fruit metabolites. Therefore, the present study was designed to evaluate the diversity of fruit morphology, fruiting habit, capsaicinoids and other metabolite contents in 136 different genotypes mainly collected from North East India...
2016: PloS One
https://www.readbyqxmd.com/read/27936037/the-antioxidative-fraction-of-white-mulberry-induces-apoptosis-through-regulation-of-p53-and-nf%C3%AE%C2%BAb-in-eac-cells
#8
Ahm Khurshid Alam, Asm Sakhawat Hossain, Muhammad Ali Khan, Syed Rashel Kabir, Md Abu Reza, Md Mahbubur Rahman, Mohammad Saiful Islam, Md Aziz Abdur Rahman, Mamunur Rashid, Md Golam Sadik
In this study, the antioxidative fraction of white mulberry (Morus alba) was found to have an apotogenic effect on Ehrlich's ascites carcinoma cell-induced mice (EAC mice) that correlate with upregulated p53 and downregulated NFκB signaling. The antioxidant activities and polyphenolic contents of various mulberry fractions were evaluated by spectrophotometry and the ethyl acetate fraction (EAF) was selected for further analysis. Strikingly, the EAF caused 70.20% tumor growth inhibition with S-phase cell cycle arrest, normalized blood parameters including red/white blood cell counts and suppressed the tumor weight of EAC mice compared with untreated controls...
2016: PloS One
https://www.readbyqxmd.com/read/27935659/exploring-the-least-studied-australian-eucalypt-genera-corymbia-and-angophora-for-phytochemicals-with-anticancer-activity-against-pancreatic-malignancies
#9
Deep Jyoti Bhuyan, Quan V Vuong, Danielle R Bond, Anita C Chalmers, Ian A van Altena, Michael C Bowyer, Christopher J Scarlett
While the pharmacological and toxicological properties of eucalypts are well known in indigenous Australian medicinal practice, investigations of the bioactivity of eucalypt extracts against high mortality diseases such as pancreatic cancer in Western medicine have to date been limited, particularly amongst the genera Corymbia and Angophora. Four Angophora and Corymbia species were evaluated for their phytochemical profile and efficacy against both primary and secondary pancreatic cancer cell lines. The aqueous leaf extract of Angophora hispida exhibited statistically higher total phenolic content (107...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27935658/three-new-iridoid-glycosides-from-the-aerial-parts-of-asperula-involucrata
#10
Hasan Kırmızıbekmez, Kubilay Tiftik, Norbert Kúsz, Orsolya Orban-Gyapai, Zoltán Péter Zomborszki, Judit Hohmann
Three new iridoid glycosides, named involucratosides A-C (1-3) were isolated from the H2 O subextract of crude MeOH extract prepared from the aerial parts of Asperula involucrata along with a known iridoid glycoside (adoxoside), three flavone glycosides (apigenin 7-O-β-glucopyranoside, luteolin 7-O-β-glucopyranoside, apigenin 7-O-rutinoside) as well as two phenolic acid derivatives (chlorogenic acid and ferulic acid 4-O-β-glucopyranoside). Their chemical structures were established by UV, IR, 1D- ((1) H, (13) C and JMOD) and 2D- (COSY, HSQC, HMBC and NOESY) NMR experiments and HRESIMS...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27935258/polyphenols-from-lonicera-caerulea-l-berry-attenuate-experimental-nonalcoholic-steatohepatitis-by-inhibiting-proinflammatory-cytokines-productions-and-lipid-peroxidation
#11
Shusong Wu, Satoshi Yano, Ayami Hisanaga, Xi He, Jianhua He, Kozue Sakao, De-Xing Hou
SCOPE: Nonalcoholic steatohepatitis (NASH) is a common disease that closely associated with inflammation and oxidative stress, and Lonicera caerulea L. polyphenols (LCP) are reported to possess both antioxidant and anti-inflammatory properties. This study aimed to study the protective effects and mechanisms of LCP on NASH in a high fat diet (HFD) plus carbon tetrachloride (CCL4 )-induced mouse model. METHODS AND RESULTS: Mice were fed with HFD containing LCP (0...
December 9, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27935234/analysis-of-antioxidative-factors-related-to-amd-risk-development-in-the-polish-patients
#12
Malgorzata Mrowicka, Jerzy Mrowicki, Jacek Pawel Szaflik, Marta Szaflik, Magdalena Ulinska, Jerzy Szaflik, Ireneusz Majsterek
PURPOSE: Age-related macular degeneration (AMD) is a major cause of blindness in developed countries. Oxidative mechanisms may play a key role in the aetiology of AMD. The main aim of this study was to investigate antioxidative markers in the pathogenesis of AMD. METHODS: A total of 510 subjects including 240 patients with AMD (mean age 77.9 ± 8.5 year) and 270 controls (mean age 74.0 ± 10.4 year) were allowed in this study. We measured activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and examined their association with the SNPs of respective genes (SOD1 + 35A/C, CAT C-262T and GPx Pro197Leu)...
December 9, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27935227/preparative-isolation-of-bioactive-compounds-from-stem-bark-of-juglans-mandshurica-by-using-high-speed-counter-current-chromatography
#13
Yuwei Zhang, Hua Lin, Shanshan Li, Jianbo Chen, Yinshi Sun, Yuxin Li
High-speed counter-current chromatography was applied for the first time to the separation and purification of bioactive compounds contained in the stem bark of Juglans mandshurica Maxim. Silica gel column chromatography was first used to obtain three composition-enriched target fractions from a crude J. mandshurica methanol extract. Three independent high-speed counter-current chromatography processes were then used to further isolate 13 bioactive compounds, namely, six galloyl glucose derivatives, three flavonones, three naphthoquinones, and ethyl gallate...
December 9, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27935208/antioxidant-properties-of-coenzyme-q10-pretreated-mouse-pre-antral-follicles-derived-from-vitrified-ovaries
#14
Elmira Hosseinzadeh, Saeed Zavareh, Taghi Lashkarbolouki
AIM: This study evaluated the antioxidant status of pre-antral follicles derived from vitrified ovaries pretreated with coenzyme Q10 (CoQ10). METHODS: Mouse pre-antral follicles derived from fresh and vitrified warmed ovarian tissue were cultured with or without CoQ10 (50 μmol/L). Follicular growth, total antioxidant capacity (TAC), malondialdehyde (MDA) level, and superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) activity during cultivation were assessed...
December 9, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27935176/effects-of-alpha-lipoic-acid-supplementation-on-growth-performance-antioxidant-capacity-and-biochemical-parameters-for-ammonia-exposed-broilers
#15
Min Lu, Jie Bai, Fengxian Wei, Bin Xu, Quanyou Sun, Jie Li, Gaili Wang, Xiangfang Tang, Hongfu Zhang, Qingqiang Yin, Shaoyu Li
In order to estimate the effect of alpha-lipoic acid (LA) supplementation on relieving ammonia stress of broilers, 180 22-day-old male broilers were assigned to three groups, six replicates in each group and 10 birds per replicate. The three groups were: (1) a control group without ammonia stress; (2) exposure to 70 ppm atmospheric ammonia (AM); (3) exposure to 70 ppm atmospheric ammonia and administration of 300 mg/kg LA (AM + LA). The experimental period was 3 weeks. Results showed that average daily weight gain was increased and feed conversion ratio was decreased in the AM + LA group, compared with the AM group (P < 0...
December 9, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27935136/a-possible-s-glutathionylation-of-specific-proteins-by-glyoxalase-ii-an-in-vitro-and-in-silico-study
#16
Luisa Ercolani, Andrea Scirè, Roberta Galeazzi, Luca Massaccesi, Laura Cianfruglia, Adolfo Amici, Francesco Piva, Lorena Urbanelli, Carla Emiliani, Giovanni Principato, Tatiana Armeni
: Glyoxalase II, the second of 2 enzymes in the glyoxalase system, is a hydroxyacylglutathione hydrolase that catalyses the hydrolysis of S-d-lactoylglutathione to form d-lactic acid and glutathione, which is released from the active site. The tripeptide glutathione is the major sulfhydryl antioxidant and has been shown to control several functions, including S-glutathionylation of proteins. S-Glutathionylation is a way for the cells to store reduced glutathione during oxidative stress, or to protect protein thiol groups from irreversible oxidation, and few enzymes involved in protein S-glutathionylation have been found to date...
December 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27935073/no-accumulation-alleviates-h2-o2-dependent-oxidative-damage-induced-by-ca-no3-2-stress-in-the-leaves-of-pumpkin-grafted-cucumber-seedlings
#17
Lin Li, Sheng Shu, Qing Xu, Ya-Hong An, Jin Sun, Shi-Rong Guo
Nitric oxide (NO) and hydrogen peroxide (H2 O2 ), two important signalling molecules, are stimulated in plants by abiotic stresses. In this study, we investigated the role of NO and its interplay with H2 O2 in the response of self-grafted and salt-tolerant pumpkin-grafted (Cucurbita maxima × C. moschata) cucumber seedlings to 80 mM Ca(NO3 )2 stress. Endogenous NO and H2 O2 production in self-grafted seedlings increased in a time-dependent manner, reaching maximum levels after 24 h of Ca(NO3 )2 stress. In contrast, a transient increase in NO production, accompanied by H2 O2 accumulation, was observed at 2 h in rootstock-grafted plants...
December 9, 2016: Physiologia Plantarum
https://www.readbyqxmd.com/read/27935050/the-anthocyanins-oenin-and-callistephin-protect-rpe-cells-against-oxidative-stress
#18
Sally M Yacout, Elizabeth R Gaillard
The retinal pigment epithelium (RPE) is a highly metabolic layer of post-mitotic cells lining the Bruch's membrane in the retina. While these cells contain endogenous photosensitizers that mediate blue light induced damage, it has also been shown that blue light exposure damages mitochondrial DNA in RPE cells resulting in mitochondrial dysfunction and unregulated generation of reactive oxygen species. As RPE cells are post-mitotic, it is imperative to decrease oxidative stress to these cells and preserve function...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27934969/quantitative-hdl-proteomics-identifies-peroxiredoxin-6-as-a-biomarker-of-human-abdominal-aortic-aneurysm
#19
Elena Burillo, Inmaculada Jorge, Diego Martínez-López, Emilio Camafeita, Luis Miguel Blanco-Colio, Marco Trevisan-Herraz, Iakes Ezkurdia, Jesús Egido, Jean-Baptiste Michel, Olivier Meilhac, Jesús Vázquez, Jose Luis Martin-Ventura
High-density lipoproteins (HDLs) are complex protein and lipid assemblies whose composition is known to change in diverse pathological situations. Analysis of the HDL proteome can thus provide insight into the main mechanisms underlying abdominal aortic aneurysm (AAA) and potentially detect novel systemic biomarkers. We performed a multiplexed quantitative proteomics analysis of HDLs isolated from plasma of AAA patients (N = 14) and control study participants (N = 7). Validation was performed by western-blot (HDL), immunohistochemistry (tissue), and ELISA (plasma)...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934917/co-delivery-of-docetaxel-and-palmitoyl-ascorbate-by-liposome-for-enhanced-synergistic-antitumor-efficacy
#20
Junxiu Li, Chaorui Guo, Fan Feng, Ali Fan, Yu Dai, Ning Li, Di Zhao, Xijing Chen, Yang Lu
Palmitoyl ascorbate (PA) as an antioxidant has the potential for the treatment of cancer. In the present study, a nanocarrier system was developed for co-delivery of docetaxel (DOC) with palmitoyl ascorbate and the therapeutic efficacy of a combination drug regimen was investigated. For this purpose, different ratios of docetaxel and palmitoyl ascorbate were co-encapsulated in a liposome and they all showed high encapsulation efficiency. The average diameters of the liposomes ranged from 140 to 170 nm. Negative zeta potential values were observed for all systems, ranged from -40 mV to -56 mV...
December 9, 2016: Scientific Reports
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