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https://www.readbyqxmd.com/read/29443965/a-molecular-atlas-of-cell-types-and-zonation-in-the-brain-vasculature
#1
Michael Vanlandewijck, Liqun He, Maarja Andaloussi Mäe, Johanna Andrae, Koji Ando, Francesca Del Gaudio, Khayrun Nahar, Thibaud Lebouvier, Bàrbara Laviña, Leonor Gouveia, Ying Sun, Elisabeth Raschperger, Markus Räsänen, Yvette Zarb, Naoki Mochizuki, Annika Keller, Urban Lendahl, Christer Betsholtz
Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29438924/chemotherapy-is-administered-to-a-minority-of-hospitalized-patients-with-diffuse-large-b-cell-lymphoma-and-is-associated-with-less-likelihood-of-death-during-hospitalization
#2
Anita J Kumar, Tobi Henzer, Angie Mae Rodday, Susan K Parsons
BACKGROUND: While treatment of DLBCL is largely outpatient, some patients require planned or unplanned admissions for chemotherapy, new diagnosis, relapse, or toxicity. We examined risk factors for receipt of inpatient chemotherapy and death during hospitalization. METHODS: We analyzed data from the 2012-2013 HCUP-NIS. We identified patient and hospital characteristics that were associated with chemotherapy administration and death. RESULTS: Chemotherapy was given in 3260/11,150 (29...
February 10, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29438279/recent-updates-on-treatment-of-ocular-microbial-infections-by-stem-cell-therapy-a-review
#3
REVIEW
Seoh Wei Teh, Pooi Ling Mok, Munirah Abd Rashid, Mae-Lynn Catherine Bastion, Normala Ibrahim, Akon Higuchi, Kadarkarai Murugan, Rajan Mariappan, Suresh Kumar Subbiah
Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area...
February 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29437639/soluble-gpvi-is-elevated-in-injured-patients-shedding-is-mediated-by-fibrin-activation-of-gpvi
#4
Samantha J Montague, Céline Delierneux, Christelle Lecut, Nathalie Layios, Robert J Dinsdale, Christine S-M Lee, Natalie S Poulter, Robert K Andrews, Peter Hampson, Christopher M Wearn, Nathalie Maes, Jonathan Bishop, Amy Bamford, Chris Gardiner, Woei Ming Lee, Tariq Iqbal, Naiem Moiemen, Steve P Watson, Cécile Oury, Paul Harrison, Elizabeth E Gardiner
Soluble glycoprotein VI (sGPVI) is shed from the platelet surface and is a marker of platelet activation in thrombotic conditions. We assessed sGPVI levels together with patient and clinical parameters in acute and chronic inflammatory conditions, including patients with thermal injury and inflammatory bowel disease and patients admitted to the intensive care unit (ICU) for elective cardiac surgery, trauma, acute brain injury, or prolonged ventilation. Plasma sGPVI was measured by enzyme-linked immunosorbent assay and was elevated on day 14 after thermal injury, and was higher in patients who developed sepsis...
February 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29435264/climatic-forcing-and-larval-dispersal-capabilities-shape-the-replenishment-of-fishes-and-their-habitat-forming-biota-on-a-tropical-coral-reef
#5
Shaun K Wilson, Martial Depcyznski, Rebecca Fisher, Thomas H Holmes, Mae M Noble, Ben T Radford, Michael Rule, George Shedrawi, Paul Tinkler, Christopher J Fulton
Fluctuations in marine populations often relate to the supply of recruits by oceanic currents. Variation in these currents is typically driven by large-scale changes in climate, in particular ENSO (El Nino Southern Oscillation). The dependence on large-scale climatic changes may, however, be modified by early life history traits of marine taxa. Based on eight years of annual surveys, along 150 km of coastline, we examined how ENSO influenced abundance of juvenile fish, coral spat, and canopy-forming macroalgae...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29433466/problem-drinking-among-flemish-students-beverage-type-early-drinking-onset-and-negative-personal-social-consequences
#6
Sara De Bruyn, Edwin Wouters, Koen Ponnet, Joris Van Damme, Lea Maes, Guido Van Hal
BACKGROUND: Although alcohol is socially accepted in most Western societies, studies are clear about its associated negative consequences, especially among university and college students. Studies on the relationship between alcohol-related consequences and both beverage type and drinking onset, however, are scarce, especially in a European context. The aim of this research was, therefore, twofold: (1) What is the relationship between beverage type and the negative consequences experienced by students? and (2) Are these consequences determined by early drinking onset? We will examine these questions within the context of a wide range of alcohol-related consequences...
February 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29431735/vhl-deletion-in-osteoblasts-boosts-cellular-glycolysis-and-improves-global-glucose-metabolism
#7
Naomi Dirckx, Robert J Tower, Evi M Mercken, Roman Vangoitsenhoven, Caroline Moreau-Triby, Tom Breugelmans, Elena Nefyodova, Ruben Cardoen, Chantal Mathieu, Bart Van der Schueren, Cyrille B Confavreux, Thomas L Clemens, Christa Maes
The skeleton has emerged as an important regulator of systemic glucose homeostasis, with osteocalcin and insulin representing prime mediators of the interplay between bone and energy metabolism. However, genetic evidence indicates that osteoblasts can influence global energy metabolism through additional, as yet unknown, mechanisms. Here, we report that constitutive or postnatally induced deletion of the hypoxia signaling pathway component von Hippel-Lindau (VHL) in skeletal osteolineage cells of mice led to high bone mass as well as hypoglycemia and increased glucose tolerance, not accounted for by osteocalcin or insulin...
February 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29427390/prevention-of-acute-radiodermatitis-by-photobiomodulation-a-randomized-placebo-controlled-trial-in-breast-cancer-patients-transdermis-trial
#8
Jolien Robijns, Sandrine Censabella, Stefan Claes, Luc Pannekoeke, Lore Bussé, Dora Colson, Iris Kaminski, Paul Bulens, Annelies Maes, Leen Noé, Marc Brosens, An Timmermans, Ivo Lambrichts, Veerle Somers, Jeroen Mebis
OBJECTIVE: Acute radiodermatitis (RD) is a distressing and painful skin reaction that occurs in 95% of the patients undergoing radiotherapy (RT). The aim of this study was to evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention of acute RD in breast cancer (BC) patients undergoing RT. METHODS: This study was a randomized, placebo-controlled trial including 120 BC patients that underwent an identical RT regimen post-lumpectomy. Patients were randomly assigned to the laser therapy (LT) or placebo group, with 60 patients in each group...
February 10, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29425932/ablation-of-c-ebp-homologous-protein-attenuates-renal-fibrosis-after-ureteral-obstruction-by-reducing-autophagy-and-microtubule-disruption
#9
Mi Ra Noh, Chang-Hoon Woo, Mae-Ja Park, Jee In Kim, Kwon Moo Park
Fibrosis is an undesirable consequence of injury and a critical problem in many diseases. Recent studies have demonstrated an association of C/EBP homologous protein (CHOP) with fibrosis. We investigated the mechanism of CHOP in kidney fibrosis progression after unilateral ureteral obstruction (UUO) using Chop gene-deleted (Chop-/-) mice and their wild-type littermates (Chop+/+). UUO-induced kidney fibrosis was reduced in the Chop-/- than Chop+/+ mice. After UUO, CHOP expression was detected in the cytosol and nucleus of distal tubule cells and collecting duct cells of the kidney...
February 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29425734/in-vitro-and-in-vivo-pharmacodynamics-of-three-novel-antileishmanial-lead-series
#10
M Van den Kerkhof, D Mabille, E Chatelain, C E Mowbray, S Braillard, S Hendrickx, L Maes, G Caljon
OBJECTIVES: Three new chemical series (bicyclic nitroimidazoles, aminopyrazoles and oxaboroles) were selected by Drugs for Neglected Diseases initiative as potential new drug leads for leishmaniasis. Pharmacodynamics studies included both in vitro and in vivo efficacy, cross-resistance profiling against the current antileishmanial reference drugs and evaluation of their cidal activity potential. METHODS: Efficacy against the reference laboratory strains of Leishmania infantum (MHOM/MA(BE)/67/ITMAP263) and L...
January 31, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29425471/antidiabetic-effect-of-rosella-stevia-tea-on-prediabetic-women-in-yogyakarta-indonesia
#11
Noor Rohmah Mayasari, Susetyowati, Mae Sri Hartati Wahyuningsih, Probosuseno
BACKGROUND: Rosella tea (Hibiscuss sabdariffa. Linn) with stevia sweetener (Stevia rebaudiana Bertoni) is a combined herbal drink that is expected to have antidiabetic effect by lowering glucose levels in people with diabetes and prediabetes. This research investigates the effect of rosella-stevia tea to decrease fasting blood glucose (FBG) and 2 hours postprandial blood glucose (2-hour postprandial BG) level in prediabetic women. METHOD: This is quasi-experimental research with control and treatment (rosella-stevia tea) group...
February 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29425157/nectandra-grandiflora-by-products-obtained-by-alternative-extraction-methods-as-a-source-of-phytochemicals-with-antioxidant-and-antifungal-properties
#12
Daniela Thomas da Silva, Rene Herrera, Berta Maria Heinzmann, Javier Calvo, Jalel Labidi
Nectandra grandiflora Nees (Lauraceae) is a Brazilian native tree recognized by its durable wood and the antioxidant compounds of its leaves. Taking into account that the forest industry offers the opportunity to recover active compounds from its residues and by-products, this study identifies and underlines the potential of natural products from Nectandra grandiflora that can add value to the forest exploitation. This study shows the effect of three different extraction methods: conventional (CE), ultrasound-assisted (UAE) and microwave-assisted (MAE) on Nectandra grandiflora leaf extracts (NGLE) chemical yields, phenolic and flavonoid composition, physical characteristics as well as antioxidant and antifungal properties...
February 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29424240/report-of-in-vitro-antileishmanial-properties-of-iberian-macroalgae
#13
Carolina Bruno de Sousa, João Henrique G Lago, Jorge Macridachis, Marta Oliveira, Luis Brito, Catarina Vizetto-Duarte, Cláudia Florindo, Sarah Hendrickx, Louis Maes, Thiago Morais, Miriam Uemi, Luís Neto, Lídia Dionísio, Sofia Cortes, Luísa Barreira, Luísa Custódio, Fernando Alberício, Lenea Campino, João Varela
Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5...
February 9, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29414003/wavenumber-selection-method-to-determine-the-concentration-of-cocaine-and-adulterants-in-cocaine-samples
#14
A Kahmann, M J Anzanello, F S Fogliatto, M C A Marcelo, M F Ferrão, R S Ortiz, K C Mariotti
Street cocaine is typically altered with several compounds that increase its harmful health-related side effects, most notably depression, convulsions, and severe damages to the cardiovascular system, lungs, and brain. Thus, determining the concentration of cocaine and adulterants in seized drug samples is important from both health and forensic perspectives. Although FTIR has been widely used to identify the fingerprint and concentration of chemical compounds, spectroscopy datasets are usually comprised of thousands of highly correlated wavenumbers which, when used as predictors in regression models, tend to undermine the predictive performance of multivariate techniques...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29411183/renal-shear-wave-elastography-for-the-assessment-of-nephron-hypertrophy-a-cross-sectional-study-in-chronic-kidney-disease
#15
Takuji Iyama, Tomoaki Takata, Masahiko Koda, Satoko Fukuda, Shotaro Hoi, Yukari Mae, Takeaki Fukui, Chishio Munemura, Hajime Isomoto
PURPOSE: To investigate the association of renal elasticity to microscopic findings of nephron hypertrophy and nephrosclerosis. METHODS: Patients who underwent renal biopsy were enrolled. Renal elasticity was measured by acoustic radiation force impulse, and nephron size (glomerular volume, non-sclerotic glomerular density, and mean profile tubular area) and nephrosclerosis (globally sclerotic glomeruli and interstitial fibrosis) were estimated. Nephron hypertrophy was indicated by larger glomerular volume, larger tubular area, and lower non-sclerotic glomerular density...
February 6, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29409654/process-evaluation-of-a-participatory-organizational-change-program-to-reduce-musculoskeletal-and-slip-trip-and-fall-injuries
#16
Dwayne Van Eerd, Era Mae Ferron, Teresa D'Elia, Derek Morgan, Frances Ziesmann, Benjamin C Amick
BACKGROUND: Long-term care (LTC) workers are at significant risk for occupational-related injuries. Our objective was to evaluate the implementation process of a participatory change program to reduce risk. METHODS: A process evaluation was conducted in three LTC sites using a qualitative approach employing structured interviews, consultant logs and a focus group. RESULTS: Findings revealed recruitment/reach themes of being "voluntold", using established methods, and challenges related to work schedules...
April 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29408694/fructose-and-sugar-a-major-mediator-of-nonalcoholic-fatty-liver-disease
#17
REVIEW
Thomas Jensen, Manal F Abdelmalek, Shelby Sullivan, Kristen J Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, Masanari Kuwabara, Yuka Sato, Duk-Hee Kang, Dean R Tolan, Laura G Sanchez-Lozada, Hugo R Rosen, Miguel A Lanaspa, Anna Mae Diehl, Richard J Johnson
Nonalcoholic Fatty Liver Disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result from overnutrition and sedentary lifestyle, recent evidence suggests that diets high in sugar (from sucrose and/or high fructose corn syrup (HFCS)) not only increases the risk for NAFLD, but also, nonalcoholic steatohepatitis (NASH). Here we review the experimental and clinical evidence that fructose precipitates fat accumulation in the liver, due to both increased lipogenesis and impaired fat oxidation...
January 31, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29406371/pediatric-specialty-care-model-for-management-of-chronic-respiratory-failure-cost-and-savings-implications-and-misalignment-with-payment-models
#18
Robert J Graham, Michael L McManus, Angie Mae Rodday, Ruth Ann Weidner, Susan K Parsons
OBJECTIVE: To describe program design, costs, and savings implications of a critical care-based care coordination model for medically complex children with chronic respiratory failure. DESIGN: All program activities and resultant clinical outcomes were tracked over 4 years using an adapted version of the Care Coordination Measurement Tool. Patient characteristics, program activity, and acute care resource utilization were prospectively documented in the adapted version of the Care Coordination Measurement Tool and retrospectively cross-validated with hospital billing data...
February 3, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29405659/spatial-dynamics-and-mixing-of-bluefin-tuna-in-the-atlantic-ocean-and-mediterranean-sea-revealed-using-next-generation-sequencing
#19
Gregory N Puncher, Alessia Cariani, Gregory E Maes, Jeroen Van Houdt, Koen Herten, Rita Cannas, Naiara Rodriguez-Ezpeleta, Aitor Albaina, M Andone Estonba, Molly Lutcavage, Alex Hanke, Jay Rooker, James S Franks, Joseph M Quattro, Gualtiero Basilone, Igaratza Fraile, Urtzi Laconcha, Nicolas Goñi, Ai Kimoto, A David Macías, Francisco Alemany, Simeon Deguara, Salem W Zgozi, Fulvio Garibaldi, Isik K Oray, F Saadet Karakulak, Noureddine Abid, Miguel N Santos, Piero Addis, Haritz Arrizabalaga, Fausto Tinti
The Atlantic bluefin tuna is a highly migratory species emblematic of the challenges associated with shared fisheries management. In an effort to resolve the species' stock dynamics, a genome-wide search for spatially informative single nucleotide polymorphisms (SNPs) was undertaken, by way of sequencing reduced representation libraries. An allele frequency approach to SNP discovery was used, combining the data of 555 larvae and young-of-the-year (LYOY) into pools representing major geographical areas and mapping against a newly assembled genomic reference...
February 6, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29404850/mabal-a-novel-deep-learning-architecture-for-machine-assisted-bone-age-labeling
#20
Simukayi Mutasa, Peter D Chang, Carrie Ruzal-Shapiro, Rama Ayyala
Bone age assessment (BAA) is a commonly performed diagnostic study in pediatric radiology to assess skeletal maturity. The most commonly utilized method for assessment of BAA is the Greulich and Pyle method (Pediatr Radiol 46.9:1269-1274, 2016; Arch Dis Child 81.2:172-173, 1999) atlas. The evaluation of BAA can be a tedious and time-consuming process for the radiologist. As such, several computer-assisted detection/diagnosis (CAD) methods have been proposed for automation of BAA. Classical CAD tools have traditionally relied on hard-coded algorithmic features for BAA which suffer from a variety of drawbacks...
February 5, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
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