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https://www.readbyqxmd.com/read/28820985/human-bone-marrow-as-a-tissue-in-post-mortem-identification-and-determination-of-psychoactive-substances-screening-methodology
#1
Renata Wietecha-Posłuszny, Sofia Lendor, Magdalena Garnysz, Marcin Zawadzki, Paweł Kościelniak
The aim of this study was to apply a new instrumental approach to the analysis of human bone marrow for forensic purposes. A new screening method for the detection of more than 30 psychoactive drugs in bone marrow was developed and applied to case samples. The drugs used in this study belonged to the following groups: benzodiazepines (BZDs, n=16), tricyclic antidepressants (TCAs, n=5), selective serotonin reuptake inhibitors (SSRI, n=4), serotonin-norepinephrine reuptake inhibitors (n=1), anticonvulsants (n=1), imidazopyridines (n=1) and piperazines (n=3)...
August 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28820033/unregulated-saphenous-vein-graft-distension-decreases-tissue-viscoelasticity
#2
Eric S Wise, Kyle M Hocking, Brian C Evans, Craig L Duvall, Joyce Cheung-Flynn, Colleen M Brophy
OBJECTIVES: Unregulated intraoperative distension of human saphenous vein (SV) graft leads to supraphysiologic luminal pressures and causes acute physiologic and cellular injury to the conduit. The effect of distension on tissue viscoelasticity, a biophysical property critical to a successful graft, is not well described. In this investigation, we quantify the loss of viscoelasticity in SV deformed by distension and compare the results to tissue distended in a pressure-controlled fashion...
September 2017: Perfusion
https://www.readbyqxmd.com/read/28818341/harnessing-the-power-of-genomics-to-secure-the-future-of-seafood
#3
REVIEW
Louis Bernatchez, Maren Wellenreuther, Cristián Araneda, David T Ashton, Julia M I Barth, Terry D Beacham, Gregory E Maes, Jann T Martinsohn, Kristina M Miller, Kerry A Naish, Jennifer R Ovenden, Craig R Primmer, Young Suk Ho, Nina O Therkildsen, Ruth E Withler
Best use of scientific knowledge is required to maintain the fundamental role of seafood in human nutrition. While it is acknowledged that genomic-based methods allow the collection of powerful data, their value to inform fisheries management, aquaculture, and biosecurity applications remains underestimated. We review genomic applications of relevance to the sustainable management of seafood resources, illustrate the benefits of, and identify barriers to their integration. We conclude that the value of genomic information towards securing the future of seafood does not need to be further demonstrated...
August 14, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28818113/respiratory-syncytial-virus-rsv-entry-is-inhibited-by-serine-protease-inhibitor-aebsf-when-present-during-an-early-stage-of-infection
#4
Winke Van der Gucht, Annelies Leemans, Marjorie De Schryver, Annick Heykers, Guy Caljon, Louis Maes, Paul Cos, Peter L Delputte
BACKGROUND: Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. Therefore, these cellular proteases are putative targets for the development of antivirals that inhibit their activity. Host proteases have been described to play essential roles in Ebola, HCV, HIV and influenza, such that specific protease inhibitors are able to reduce infection. RSV utilizes a host protease in its replication cycle but its potential as antiviral target is unknown...
August 17, 2017: Virology Journal
https://www.readbyqxmd.com/read/28818061/estimating-correlation-between-multivariate-longitudinal-data-in-the-presence-of-heterogeneity
#5
Feng Gao, J Philip Miller, Chengjie Xiong, Jingqin Luo, Julia A Beiser, Ling Chen, Mae O Gordon
BACKGROUND: Estimating correlation coefficients among outcomes is one of the most important analytical tasks in epidemiological and clinical research. Availability of multivariate longitudinal data presents a unique opportunity to assess joint evolution of outcomes over time. Bivariate linear mixed model (BLMM) provides a versatile tool with regard to assessing correlation. However, BLMMs often assume that all individuals are drawn from a single homogenous population where the individual trajectories are distributed smoothly around population average...
August 17, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28814718/adaptive-and-non-adaptive-divergence-in-a-common-landscape
#6
Joost A M Raeymaekers, Anurag Chaturvedi, Pascal I Hablützel, Io Verdonck, Bart Hellemans, Gregory E Maes, Luc De Meester, Filip A M Volckaert
Species in a common landscape often face similar selective environments. The capacity of organisms to adapt to these environments may be largely species specific. Quantifying shared and unique adaptive responses across species within landscapes may thus improve our understanding of landscape-moderated biodiversity patterns. Here we test to what extent populations of two coexisting and phylogenetically related fishes-three-spined and nine-spined stickleback-differ in the strength and nature of neutral and adaptive divergence along a salinity gradient...
August 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811572/inhibition-of-connexin-hemichannels-alleviates-non-alcoholic-steatohepatitis-in-mice
#7
Joost Willebrords, Bruno Cogliati, Isabel Veloso Alves Pereira, Tereza Cristina da Silva, Sara Crespo Yanguas, Michaël Maes, Veronica Mollica Govoni, Andressa Lima, Daniele Aparecida Felisbino, Elke Decrock, Marina Sayuri Nogueira, Inar Alves de Castro, Isabelle Leclercq, Luc Leybaert, Robim Marcelino Rodrigues, Mathieu Vinken
While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress. The latter are essential features of non-alcoholic steatohepatitis. In this study, it was investigated whether connexin32 and connexin43 hemichannels play a role in non-alcoholic steatohepatitis. Mice were fed a choline-deficient high-fat diet or normal diet for 8 weeks. Thereafter, TAT-Gap24 or TAT-Gap19, specific inhibitors of hemichannels composed of connexin32 and connexin43, respectively, were administered for 2 weeks...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806089/spatially-resolved-magnetic-anisotropy-of-cobalt-nanostructures-on-the-au-111-surface
#8
Puneet Mishra, Zhi Kun Qi, Hirofumi Oka, Kohji Nakamura, Tadahiro Komeda
Understanding the origin of perpendicular magnetic anisotropy in surface-supported nanoclusters is crucial for fundamental research as well as data storage applications. Here, we investigate the perpendicular magnetic anisotropy energy (MAE) of bilayer cobalt islands on Au(111) substrate using spin-polarized scanning tunneling microscopy at 4.6 K and first-principles theoretical calculations. Au(111) substrate serves as an excellent model system to study the effect of nucleation site and stacking sequence on MAE...
August 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28804468/individual-difference-factors-in-the-learning-and-transfer-of-patterning-discriminations
#9
Elisa Maes, Elias Vanderoost, Rudi D'Hooge, Jan De Houwer, Tom Beckers
In an associative patterning task, some people seem to focus more on learning an overarching rule, whereas others seem to focus on acquiring specific relations between the stimuli and outcomes involved. Building on earlier work, we further investigated which cognitive factors are involved in feature- vs. rule-based learning and generalization. To this end, we measured participants' tendency to generalize according to the rule of opposites after training on negative and positive patterning problems (i.e., A+/B+/AB- and C-/D-/CD+), their tendency to attend to global aspects or local details of stimuli, their systemizing disposition and their score on the Raven intelligence test...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28800483/assessment-of-aod-variability-over-saudi-arabia-using-modis-deep-blue-products
#10
Mohsin Jamil Butt, Mazen Ebraheem Assiri, Md Arfan Ali
The aim of this study is to investigate the variability of aerosol over The Kingdom of Saudi Arabia. For this analysis, Moderate Resolution Imaging Spectroradiometer (MODIS) Deep Blue (DB) Aerosol Optical Depth (AOD) product from Terra and Aqua satellites for the years 2000-2013 is used. The product is validated using AERONET data from ground stations, which are situated at Solar Village Riyadh and King Abdullah University of Science and Technology (KAUST) Jeddah. The results show that both Terra and Aqua satellites exhibit a tendency to show the spatial variation of AOD with Aqua being better than Terra to represent the ground based AOD measurements over the study region...
August 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28798220/vascular-access-type-and-clinical-outcomes-among-elderly-patients-on-hemodialysis
#11
Timmy Lee, Mae Thamer, Qian Zhang, Yi Zhang, Michael Allon
BACKGROUND AND OBJECTIVES: The optimal type of initial permanent access for hemodialysis among the elderly is controversial. Duration of central venous catheter dependence, patient comorbidities, and life expectancy are important considerations in whether to place an arteriovenous fistula or graft. We used an observational study design to compare clinical outcomes in elderly patients who initiated hemodialysis with a central venous catheter and subsequently had an arteriovenous fistula or graft placed...
August 10, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28797634/ecological-distribution-of-extremely-thermophilic-bacteria-belonging-to-the-genus-calditerricola-using-the-novel-enrichment-mpn-pcr-method
#12
Kathrina Mae Bienes, Minoru Ito, Kota Shiotsuka, Sachi Yamaguchi, Taiki Fujioka, Yukihiro Tashiro, Kenji Sakai
A unique compost called Satsuma soil is produced from sewage sludge by a hyperthermal composting process in Kagoshima City, Japan. The composting process is carried out at a controlled temperature of at least 80°C and the resulting compost might be useful for recycling sustainable agricultural products. The extremely thermophilic bacterial genus Calditerricola was initially isolated from the high-temperature compost. Likewise, the bacteria were previously isolated from material sludge. It is believed that bacteria in this genus might be involved in the hyperthermal composting process...
August 7, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28794678/solanum-jobsonii-a-novel-andromonoecious-bush-tomato-species-from-a-new-australian-national-park
#13
L Mae Lacey, Jason T Cantley, Christopher T Martine
A new species of Solanum from the Australian "andromonoecious bush tomato clade" of Solanum subgenus Leptostemonum is described. Solanum jobsonii Martine, J.Cantley, & L.M.Lacey, sp. nov. is part of the S. eburneum Symon species group. It most closely resembles S. eburneum and S. watneyi Martine & Frawley of the northwestern part of the Northern Territory, but is separated geographically from them by the Sturt Plateau. Morphometric analyses show that S. jobsonii differs statistically from S. eburneum, S. watneyi, and S...
2017: PhytoKeys
https://www.readbyqxmd.com/read/28790998/modified-lipid-extraction-methods-for-deep-subsurface-shale
#14
Rawlings N Akondi, Ryan V Trexler, Susan M Pfiffner, Paula J Mouser, Shikha Sharma
Growing interest in the utilization of black shales for hydrocarbon development and environmental applications has spurred investigations of microbial functional diversity in the deep subsurface shale ecosystem. Lipid biomarker analyses including phospholipid fatty acids (PLFAs) and diglyceride fatty acids (DGFAs) represent sensitive tools for estimating biomass and characterizing the diversity of microbial communities. However, complex shale matrix properties create immense challenges for microbial lipid extraction procedures...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28789902/the-role-of-hypernitrosylation-in-the-pathogenesis-and-pathophysiology-of-neuroprogressive-diseases
#15
REVIEW
Gerwyn Morris, Ken Walder, André F Carvalho, Susannah J Tye, Kurt Lucas, Michael Berk, Michael Maes
There is a wealth of data indicating that de novo protein S-nitrosylation in general and protein transnitrosylation in particular mediates the bulk of nitric oxide signalling. These processes enable redox sensing and facilitate homeostatic regulation of redox dependent protein signalling, function, stability and trafficking. Increased S-nitrosylation in an environment of increasing oxidative and nitrosative stress (O&NS) is initially a protective mechanism aimed at maintaining protein structure and function...
August 5, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28777811/a-machine-learning-approach-to-estimation-of-downward-solar-radiation-from-satellite-derived-data-products-an-application-over-a-semi-arid-ecosystem-in-the-u-s
#16
Qingtao Zhou, Alejandro Flores, Nancy F Glenn, Reggie Walters, Bangshuai Han
Shortwave solar radiation is an important component of the surface energy balance and provides the principal source of energy for terrestrial ecosystems. This paper presents a machine learning approach in the form of a random forest (RF) model for estimating daily downward solar radiation flux at the land surface over complex terrain using MODIS (MODerate Resolution Imaging Spectroradiometer) remote sensing data. The model-building technique makes use of a unique network of 16 solar flux measurements in the semi-arid Reynolds Creek Experimental Watershed and Critical Zone Observatory, in southwest Idaho, USA...
2017: PloS One
https://www.readbyqxmd.com/read/28777733/who-does-not-cut-down-comparing-characteristics-and-drinking-motives-of-drinkers-and-abstainers-during-the-exam-periods
#17
Joris Van Damme, Anne Hublet, Bart De Clercq, Emmanuel Kuntsche, Lea Maes, Els Clays
OBJECTIVE: Drinking alcohol during the exams can affect academic performance and future career options, but is rarely investigated. Drinking motives, socio-demographics and personality characteristics are investigated in non-abstainers and weekly drinkers during the exams. PARTICIPANTS: 7,181 Belgian university students who anonymously responded to an email invitation to an online survey. METHODS: Logistic regressions and mixed design analysis-of-variance on cross-sectional data...
August 4, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28776008/electrosynthesis-a-new-frontier-in-aerobic-oxidation
#18
Carlo Sambiagio, Hans Sterckx, Bert U W Maes
No abstract text is available yet for this article.
July 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28775299/construction-and-evaluation-of-two-computational-models-for-predicting-the-incidence-of-influenza-in-nagasaki-prefecture-japan
#19
Fei He, Zhi-Jian Hu, Wen-Chang Zhang, Lin Cai, Guo-Xi Cai, Kiyoshi Aoyagi
It remains challenging to forecast local, seasonal outbreaks of influenza. The goal of this study was to construct a computational model for predicting influenza incidence. We built two computational models including an Autoregressive Distributed Lag (ARDL) model and a hybrid model integrating ARDL with a Generalized Regression Neural Network (GRNN), to assess meteorological factors associated with temporal trends in influenza incidence. The modelling and forecasting performance of these two models were compared using observations collected between 2006 and 2015 in Nagasaki Prefecture, Japan...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28772483/steering-the-properties-of-moox-hole-transporting-layers-in-opvs-and-oleds-interface-morphology-vs-electronic-structure
#20
Wouter Marchal, Inge Verboven, Jurgen Kesters, Boaz Moeremans, Christopher De Dobbelaere, Gilles Bonneux, Ken Elen, Bert Conings, Wouter Maes, Hans Gerd Boyen, Wim Deferme, Marlies Van Bael, An Hardy
The identification, fine-tuning, and process optimization of appropriate hole transporting layers (HTLs) for organic solar cells is indispensable for the production of efficient and sustainable functional devices. In this study, the optimization of a solution-processed molybdenum oxide (MoOx) layer fabricated from a combustion precursor is carried out via the introduction of zirconium and tin additives. The evaluation of the output characteristics of both organic photovoltaic (OPV) and organic light emitting diode (OLED) devices demonstrates the beneficial influence upon the addition of the Zr and Sn ions compared to the generic MoOx precursor...
January 30, 2017: Materials
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