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https://www.readbyqxmd.com/read/29682847/the-impact-of-acceptor-acceptor-homocoupling-on-the-optoelectronic-properties-and-photovoltaic-performance-of-pdtsqx-ff-low-bandgap-polymers
#1
Geert Pirotte, Jurgen Kesters, Tom Cardeynaels, Pieter Verstappen, Jan D'Haen, Laurence Lutsen, Benoît Champagne, Dirk Vanderzande, Wouter Maes
Push-pull-type conjugated polymers applied in organic electronics do not always contain a perfect alternation of donor and acceptor building blocks. Misscouplings can occur, which have a noticeable effect on the device performance. In this work, the influence of homocoupling on the optoelectronic properties and photovoltaic performance of PDTSQxff polymers is investigated, with a specific focus on the quinoxaline acceptor moieties. A homocoupled biquinoxaline segment is intentionally inserted in specific ratios during the polymerization...
April 22, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29681025/major-differences-in-neurooxidative-and-neuronitrosative-stress-pathways-between-major-depressive-disorder-and-types-i-and-ii-bipolar-disorder
#2
Michael Maes, Kamila Landucci Bonifacio, Nayara Rampazzo Morelli, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, André F Carvalho, Sandra Odebrecht Vargas Nunes
Accumulating evidence indicates that oxidative and nitrosative stress (O&NS) pathways play a key role in the pathophysiology of bipolar disorder (BD) and major depressive disorder (MDD). However, only a handful of studies have directly compared alterations in O&NS pathways among patients with MDD and BD types I (BPI) and BPII. Thus, the current study compared superoxide dismutase (SOD1), lipid hydroperoxides (LOOH), catalase, nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) between mood disorder patients in a clinically remitted state...
April 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29680923/taxonomy-of-the-family-arenaviridae-and-the-order-bunyavirales-update-2018
#3
Piet Maes, Sergey V Alkhovsky, Yīmíng Bào, Martin Beer, Monica Birkhead, Thomas Briese, Michael J Buchmeier, Charles H Calisher, Rémi N Charrel, Il Ryong Choi, Christopher S Clegg, Juan Carlos de la Torre, Eric Delwart, Joseph L DeRisi, Patrick L Di Bello, Francesco Di Serio, Michele Digiaro, Valerian V Dolja, Christian Drosten, Tobiasz Z Druciarek, Jiang Du, Hideki Ebihara, Toufic Elbeaino, Rose C Gergerich, Amethyst N Gillis, Jean-Paul J Gonzalez, Anne-Lise Haenni, Jussi Hepojoki, Udo Hetzel, Thiện Hồ, Ní Hóng, Rakesh K Jain, Petrus Jansen van Vuren, Qi Jin, Miranda Gilda Jonson, Sandra Junglen, Karen E Keller, Alan Kemp, Anja Kipar, Nikola O Kondov, Eugene V Koonin, Richard Kormelink, Yegor Korzyukov, Mart Krupovic, Amy J Lambert, Alma G Laney, Matthew LeBreton, Igor S Lukashevich, Marco Marklewitz, Wanda Markotter, Giovanni P Martelli, Robert R Martin, Nicole Mielke-Ehret, Hans-Peter Mühlbach, Beatriz Navarro, Terry Fei Fan Ng, Márcio Roberto Teixeira Nunes, Gustavo Palacios, Janusz T Pawęska, Clarence J Peters, Alexander Plyusnin, Sheli R Radoshitzky, Víctor Romanowski, Pertteli Salmenperä, Maria S Salvato, Hélène Sanfaçon, Takahide Sasaya, Connie Schmaljohn, Bradley S Schneider, Yukio Shirako, Stuart Siddell, Tarja A Sironen, Mark D Stenglein, Nadia Storm, Harikishan Sudini, Robert B Tesh, Ioannis E Tzanetakis, Mangala Uppala, Olli Vapalahti, Nikos Vasilakis, Peter J Walker, Guópíng Wáng, Lìpíng Wáng, Yànxiăng Wáng, Tàiyún Wèi, Michael R Wiley, Yuri I Wolf, Nathan D Wolfe, Zhìqiáng Wú, Wénxìng Xú, Li Yang, Zuòkūn Yāng, Shyi-Dong Yeh, Yǒng-Zhèn Zhāng, Yàzhōu Zhèng, Xueping Zhou, Chénxī Zhū, Florian Zirkel, Jens H Kuhn
In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently established order Bunyavirales was expanded by 3 species. This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future.
April 21, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29679745/integrated-genomic-and-metabolomic-profiling-of-isc1-an-emerging-leishmania-donovani-population-in-the-indian-subcontinent
#4
Bart Cuypers, Maya Berg, Hideo Imamura, Franck Dumetz, Géraldine De Muylder, Malgorzata A Domagalska, Suman Rijal, Narayan Raj Bhattarai, Ilse Maes, Mandy Sanders, James A Cotton, Pieter Meysman, Kris Laukens, Jean-Claude Dujardin
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases caused by L. donovani from the ISC1 genetic group, a new and emerging genotype. In this study, we perform for the first time an integrated, untargeted genomics and metabolomics approach to characterize ISC1, in comparison with the Core Group (CG), main population that drove the last outbreak of VL in the ISC...
April 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29678649/nine-month-outcomes-of-the-durability-iliac-study-on-self-expanding-stents-for-symptomatic-peripheral-artery-disease
#5
Peter Faries, Michael Jaff, Patrick Peeters, Yazan Khatib, David Roberts, Marc Bosiers, Rajesh Malik, Reid Ravin, John Rundback
OBJECTIVE: The DURABILITY Iliac clinical study evaluated the safety and effectiveness of two nitinol self-expanding stents for the treatment of atherosclerotic common and external iliac artery lesions up to 10 cm in length and >50% stenosis in subjects with Rutherford Classification peripheral arterial disease stages 2-4. METHODS: DURABILITY Iliac was a prospective, multicenter, core lab adjudicated, nonrandomized clinical study enrolling 75 subjects from 15 sites in the United States and Europe...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29677637/the-prevalence-of-molecular-markers-of-drug-resistance-in-plasmodium-vivax-from-the-border-regions-of-thailand-in-2008-and-2014
#6
Kritpaphat Tantiamornkul, Tepanata Pumpaibool, Jittima Piriyapongsa, Richard Culleton, Usa Lek-Uthai
The prevalence of Plasmodium vivax is increasing in the border regions of Thailand; one potential problem confounding the control of malaria in these regions is the emergence and spread of drug resistance. The aim of this study was to determine the genetic diversity in genes potentially linked to drug resistance in P. vivax parasites isolated from four different border regions of Thailand; Thai-Myanmar (Tak, Mae Hong Son and Prachuap Khiri Khan Provinces), and Thai-Cambodian borders (Chanthaburi Province). Isolates were collected from 345 P...
April 12, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29676529/implicit-learning-seems-to-come-naturally-for-children-with-autism-but-not-for-children-with-specific-language-impairment-evidence-from-behavioral-and-erp-data
#7
Fenny S Zwart, Constance Th W M Vissers, Roy P C Kessels, Joseph H R Maes
Autism spectrum disorder (ASD) and specific language impairment (SLI) are two neurodevelopmental disorders characterized by deficits in verbal and nonverbal communication skills. These skills are thought to develop largely through implicit-or automatic-learning mechanisms. The aim of the current paper was to investigate the role of implicit learning abilities in the atypical development of communication skills in ASD and SLI. In the current study, we investigated Response Times (RTs) and Event Related Potentials (ERPs) during implicit learning on a Serial Reaction Time (SRT) task in a group of typically developing (TD) children (n = 17), a group of autistic children (n = 16), and a group of children with SLI (n = 13)...
April 20, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29676292/the-test-retest-reliability-of-questionnaires-regarding-attitudes-and-beliefs-toward-noise-hearing-loss-and-hearing-protector-devices-in-young-adults
#8
Sofie Degeest, Leen Maes, Laura Leyssens, Hannah Keppler
Context: Young people expose themselves to high noise levels during leisure activities, and might thus be at risk of acquiring hearing-related problems. Therefore, information regarding risk-taking behavior is necessary to prevent future hearing problems and to optimize future preventive campaigns. Aim: This study evaluated the test-retest reliability of the Youth Attitude to Noise Scale (YANS) and beliefs about hearing protection and hearing loss (BAHPHL) instrument...
March 2018: Noise & Health
https://www.readbyqxmd.com/read/29675004/the-fast-growing-brucella-suis-biovar-5-depends-on-phosphoenolpyruvate-carboxykinase-and-pyruvate-phosphate-dikinase-but-not-on-fbp-and-glpx-fructose-1-6-bisphosphatases-or-isocitrate-lyase-for-full-virulence-in-laboratory-models
#9
Amaia Zúñiga-Ripa, Thibault Barbier, Leticia Lázaro-Antón, María J de Miguel, Raquel Conde-Álvarez, Pilar M Muñoz, Jean J Letesson, Maite Iriarte, Ignacio Moriyón
Bacteria of the genus Brucella infect a range of vertebrates causing a worldwide extended zoonosis. The best-characterized brucellae infect domestic livestock, behaving as stealthy facultative intracellular parasites. This stealthiness depends on envelope molecules with reduced pathogen-associated molecular patterns, as revealed by the low lethality and ability to persist in mice of these bacteria. Infected cells are often engorged with brucellae without signs of distress, suggesting that stealthiness could also reflect an adaptation of the parasite metabolism to use local nutrients without harming the cell...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674227/age-estimation-of-adult-human-remains-from-hip-bones-using-advanced-methods
#10
Anežka Kotěrová, David Navega, Michal Štepanovský, Zdeněk Buk, Jaroslav Brůžek, Eugénia Cunha
The assessment of age-at-death is an important and challenging part of investigations of human skeletal remains. The main objective of the present study was to apply different mathematical approaches in order to reach more accurate and reliable results in age estimation. A multi-ethnic dataset (n=941) of evaluated age-related changes on the pubic symphysis and the auricular surface of the hip bone was used. Two research groups examined nine different mathematical approaches. The best results were reached by Multi-linear regression, followed by the Collapsed regression model, with MAE values of 9...
April 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29673612/molecular-mechanisms-of-combined-heat-and-drought-stress-resilience-in-cereals
#11
REVIEW
Lovely Mae F Lawas, Ellen Zuther, Sv Krishna Jagadish, Dirk K Hincha
Global climate change leads to increased temperatures and decreased precipitation in many parts of the world. The simultaneous occurrence of high temperature and water deficit results in heat stress damage in plants. Cereals provide the majority of calories for human consumption, making this stress scenario particularly threatening for global food security. Several studies in both dicots and cereals indicate that the molecular reactions of plants to combined stresses cannot be predicted from reactions to single stresses...
April 16, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29673298/initial-clinical-experience-using-the-low-profile-altura-endograft-system-with-double-d-shaped-proximal-stents-for-endovascular-aneurysm-repair
#12
Dainis Krievins, Albrecht Krämer, Janis Savlovskis, Georgij Oszkinis, E Sebastian Debus, Alexander Oberhuber, Christopher K Zarins
PURPOSE: To report the initial clinical results of endovascular aneurysm repair (EVAR) using the low-profile (14-F) Altura Endograft System, which features a double "D-shaped" stent design with suprarenal fixation and modular iliac components that are deployed from distal to proximal. METHODS: From 2011 to 2015, 90 patients (mean age 72.8±8.3 years; 79 men) with abdominal aortic aneurysm (AAA; mean diameter 53.8±5.7 mm) were treated at 10 clinical sites in 2 prospective, controlled clinical studies using the Altura endograft...
April 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29672462/patient-specific-lean-body-mass-can-be-estimated-from-limited-coverage-computed-tomography-images
#13
Joke Devriese, Laurence Beels, Alex Maes, Christophe van de Wiele, Hans Pottel
OBJECTIVE: In PET/CT, quantitative evaluation of tumour metabolic activity is possible through standardized uptake values, usually normalized for body weight (BW) or lean body mass (LBM). Patient-specific LBM can be estimated from whole-body (WB) CT images. As most clinical indications only warrant PET/CT examinations covering head to midthigh, the aim of this study was to develop a simple and reliable method to estimate LBM from limited-coverage (LC) CT images and test its validity. PATIENTS AND METHODS: Head-to-toe PET/CT examinations were retrospectively retrieved and semiautomatically segmented into tissue types based on thresholding of CT Hounsfield units...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672041/targeting-a-subpocket-in-trypanosoma-brucei-phosphodiesterase-b1-tbrpdeb1-enables-the-structure-based-discovery-of-selective-inhibitors-with-trypanocidal-activity
#14
Antoni R Blaazer, Abhimanyu Kumar Singh, Erik de Heuvel, Ewald Edink, Kristina M Orrling, Johan J N Veerman, Toine van den Bergh, Chimed Jansen, Erin Balasubramaniam, Wouter J Mooij, Hans Custers, Maarten Sijm, Daniel N A Tagoe, Titilola D Kalejaiye, Jane C Munday, Hermann Tenor, An Matheeussen, Maikel Wijtmans, Marco Siderius, Chris de Graaf, Louis Maes, Harry P de Koning, David S Bailey, Geert Jan Sterk, Iwan J P De Esch, David G Brown, Rob Leurs
Several trypanosomatid cyclic nucleotide phosphodiesterases (PDEs) possess a unique, parasite-specific cavity near the ligand-binding region that is referred to as the P-pocket. One of these enzymes, Trypanosoma brucei PDE B1 (TbrPDEB1), is considered a drug target for the treatment of African sleeping sickness. Here, we elucidate the molecular determinants of inhibitor binding and reveal that the P-pocket is amenable to directed design. By iterative cycles of design, synthesis, pharmacological evaluation, and by elucidating the structures of inhibitor-bound TbrPDEB1, hPDE4B and hPDE4D complexes, we have developed 4a,5,8,8a-tetrahydrophthalazinones as the first selective TbrPDEB1 inhibitor series...
April 19, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29669889/molecular-preadaptation-to-antimony-resistance-in-leishmania-donovani-on-the-indian-subcontinent
#15
F Dumetz, B Cuypers, H Imamura, D Zander, E D'Haenens, I Maes, M A Domagalska, J Clos, J-C Dujardin, G De Muylder
Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of Leishmania donovani resistance, this drug offers a unique model for understanding drug resistance dynamics. In a previous phylogenomic study, we found two distinct populations of L. donovani : the core group (CG) in the Gangetic plains and ISC1 in the Nepalese highlands. Sb resistance was only encountered within the CG, and a series of potential markers were identified...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29669145/overview-and-assessment-of-a-full-time-family-medicine-faculty-development-fellowship
#16
Tomoko Sairenji, Jennie B Jarrett, Laura-Mae Baldwin, Stephen A Wilson
No abstract text is available yet for this article.
April 2018: Family Medicine
https://www.readbyqxmd.com/read/29665753/apical-elongation-of-molar-teeth-in-captive-microtus-voles
#17
Denise M Imai, Risa Pesapane, Christopher J Conroy, Christina N Alarcón, Nora Allan, Russell A Okino, Jennifer Fung, Brian G Murphy, Frank J M Verstraete, Janet E Foley
Molar apical elongation (MAE) was the leading cause for euthanasia or death in a captive breeding colony of endangered Amargosa voles ( Microtus californicus scirpensis). Clinical signs included ocular discharge, abnormal mastication, dyspnea, abnormal mentation, weight loss, and death. Although the severity varied, all molars in all quadrants were affected. When severe, the overgrown molar reserve crown and apex protruded into the nasal meatuses, the orbit, the calvarial vault and through the ventral margin of the mandible...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29665163/lowered-quality-of-life-in-mood-disorders-is-associated-with-increased-neuro-oxidative-stress-and-basal-thyroid-stimulating-hormone-levels-and-use-of-anticonvulsant-mood-stabilizers
#18
Caroline Sampaio Nunes, Michael Maes, Chutima Roomruangwong, Juliana Brum Moraes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Decio Sabbatini Barbosa, George Anderson, Luiz Gustavo Piccoli de Melo, Stoyanov Drozdstoj, Estefania Moreira, André F Carvalho, Sandra Odebrecht Vargas Nunes
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29663689/risk-factors-for-length-of-stay-and-charge-per-day-differ-between-older-and-younger-hospitalized-patients-with-aml
#19
Anita J Kumar, Tobi Henzer, Angie Mae Rodday, Susan K Parsons
Acute myeloid leukemia (AML) is associated with frequent hospitalizations. We evaluated factors associated with length of stay (LOS) and charge per day (CPD) for admissions in older (≥60 years) and younger patients (<60 years). We identified patients with ICD-9-CM codes for AML or myeloid sarcoma in the 2012 HCUP-NIS. In separate models based on age, we examined patient (sex, race, income, insurance payer, chronic conditions, chemotherapy administration, death) and hospital (type, geography) characteristics...
April 16, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29662010/metabolic-features-of-multiple-myeloma
#20
REVIEW
Chaima El Arfani, Kim De Veirman, Ken Maes, Elke De Bruyne, Eline Menu
Cancer is known for its cellular changes contributing to tumour growth and cell proliferation. As part of these changes, metabolic rearrangements are identified in several cancers, including multiple myeloma (MM), which is a condition whereby malignant plasma cells accumulate in the bone marrow (BM). These metabolic changes consist of generation, inhibition and accumulation of metabolites and metabolic shifts in MM cells. Changes in the BM micro-environment could be the reason for such adjustments. Enhancement of glycolysis and glutaminolysis is found in MM cells compared to healthy cells...
April 14, 2018: International Journal of Molecular Sciences
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