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https://www.readbyqxmd.com/read/28102549/enhancing-capillary-blood-collection-the-influence-of-nicotinic-acid-and-nonivamide
#1
Christian Moro, Jessica Bass, Anna Mae Scott, Elisa F D Canetti
BACKGROUND: Nicotinic acid and nonivamide are often applied topically during capillary blood collection to induce vasodilation. These molecules may have an influence on immune effector cell activity in nearby tissues. This study investigates whether the induction of flushing by nicotinic acid and nonivamide causes an inflammatory response that influences the composition of immune cells present in a capillary blood sample. METHODS: Females aged between 18 and 30 years old provided capillary blood samples...
January 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28099769/persistent-serious-mental-illness-among-former-applicants-for-va-ptsd-disability-benefits-and-long-term-outcomes-symptoms-functioning-and-employment
#2
Maureen Murdoch, Michele Roxanne Spoont, Shannon Marie Kehle-Forbes, Eileen Mae Harwood, Nina Aileen Sayer, Barbara Ann Clothier, Ann Kay Bangerter
: Millions of U.S. veterans have returned from military service with posttraumatic stress disorder (PTSD), for which a substantial number receive U.S. Department of Veterans Affairs (VA) disability benefits. Although PTSD is treatable, comorbid serious mental illness (defined here as schizophrenia, schizoaffective disorder, and bipolar spectrum disorders) could complicate these veterans' recovery. Using VA administrative data, we examined the burden of persistent serious mental illness in a nationally representative cohort of 1,067 men and 1,513 women who applied for VA PTSD disability benefits between 1994 and 1998 and served during or after the Vietnam conflict...
January 18, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28099665/adherence-to-dietary-recommendations-for-preschoolers-clinical-trial-with-teenage-mothers
#3
Betina Soldateli, Alvaro Vigo, Elsa Regina Justo Giugliani
OBJECTIVE: To assess the effect of educational dietary intervention offered in the child's first year of life, as well as teenage mothers and grandmothers in carrying out the dietary recommendations at four to seven years. METHODS: Randomized clinical trial initiated in 2006, in Porto Alegre, RS, involving 323 teenage mothers and grandmothers who cohabited. The intervention consisted of six counseling sessions on breastfeeding and healthy complementary feeding. The first session occurred in the maternity ward and the other ones in the households of mothers at seven, 15, 30, 60, and 120 days of the child's life...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28095890/impact-of-diversity-of-mycoplasma-hyopneumoniae-strains-on-lung-lesions-in-slaughter-pigs
#4
Annelies Michiels, Katleen Vranckx, Sofie Piepers, Rubén Del Pozo Sacristán, Ioannis Arsenakis, Filip Boyen, Freddy Haesebrouck, Dominiek Maes
The importance of diversity of Mycoplasma hyopneumoniae (M. hyopneumoniae) strains is not yet fully known. This study investigated the genetic diversity of M. hyopneumoniae strains in ten pig herds, and assessed associations between the presence of different strains of M. hyopneumoniae and lung lesions at slaughter. Within each herd, three batches of slaughter pigs were investigated. At slaughter, from each batch, 20 post mortem bronchoalveolar lavage fluid samples were collected for multiple locus variable-number tandem repeat analysis (MLVA), and lung lesions (Mycoplasma-like lesions, fissures) were examined...
January 17, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28093238/a-model-of-the-mitochondrial-basis-of-bipolar-disorder
#5
REVIEW
Gerwyn Morris, Ken Walder, Sean L McGee, Olivia M Dean, Susannah J Tye, Michael Maes, Michael Berk
BACKGROUND: Bipolar disorder phenomenologically is a biphasic disorder of energy availability; increased in mania and decreased in depression. In consort, there is accumulating evidence indicating increased mitochondrial respiration and ATP production in bipolar mania which contrasts with decreased mitochondrial function in patients in the euthymic or depressive phase of the illness. Consequently, the central thesis of this paper is that bipolar disorder is due to a phasic dysregulation of mitochondrial biogenergetics...
January 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28090004/difference-in-dynamic-body-balance-between-forward-and-lateral-single-leg-hop-landing
#6
Yukiko Kawakami, Issei Ogasawara, Yasukazu Yonetani, Rikio Takao, Tatsuo Mae, Ken Nakata, Shuji Horibe
Since the loss of balance can result in falls or lower extremity injuries during sports or daily activities, quantitative evaluation of one's ability to maintain balance with changes in the direction of motion is crucial. The present study aimed to assess whether the trajectory length of the center of pressure (COP) and peak values of the ground reaction force (GRF) following a single-leg hop landing differ when hopping forward or laterally, and to ascertain disparities in balance characteristics due to differences in hop direction...
January 16, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28088515/the-membrane-tethered-nac-transcription-factor-atntl7-contributes-to-er-stress-resistance-in-arabidopsis
#7
Yong Hun Chi, Sarah Mae Boyles Melencion, Cresilda Vergara Alinapon, Min Ji Kim, Eun Seon Lee, Seol Ki Paeng, Joung Hun Park, Ganesh M Nawkar, Young Jun Jung, Ho Byeong Chae, Chang Ho Kang, Sang Yeol Lee
We screened for endoplasmic reticulum (ER) stress-resistant mutants among 25 mutants of the Arabidopsis NTL (NAC with Transmembrane motif 1-Like) family. We identified a novel mutant, SALK_044777, showing strong resistance to ER stress. RT-PCR and genomic DNA sequence analyses identified the mutant as atntl7, which harbors a T-DNA insertion in the fourth exon of AtNTL7. Two other atntl7-mutant alleles, in which T-DNA was inserted in the second exon and third intron of AtNTL7, respectively, showed ER-stress sensitive phenotypes, suggesting that SALK_044777 is a gain-of-function mutant...
January 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28077621/functional-redundancy-and-non-redundancy-between-two-troponin-c-isoforms-in-drosophila-adult-muscles
#8
Maria B Chechenova, Sara Maes, Sandy T Oas, Cloyce Nelson, Kaveh G Kiani, Anton L Bryantsev, Richard M Cripps
We investigated the functional overlap of two muscle Troponin C (TpnC) genes that are expressed in the adult fruit fly, Drosophila melanogaster: TpnC4 is predominantly expressed in the indirect flight muscles (IFM), whereas TpnC41C is the main isoform in the tergal depressor of the trochanter muscle (TDT or jump muscle). Using CRISPR/Cas9, we created a transgenic line with a homozygous deletion of TpnC41C, and compared its phenotype to a line lacking functional TpnC4 We found that the removal of either of these genes leads to expression of the other isoform in both muscle types...
January 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28077157/clinical-biochemical-and-molecular-characteristics-of-filipino-patients-with-mucopolysaccharidosis-type-ii-hunter-syndrome
#9
Mary Anne D Chiong, Daffodil M Canson, Mary Ann R Abacan, Melissa Mae P Baluyot, Cynthia P Cordero, Catherine Lynn T Silao
BACKGROUND: Mucopolysaccharidosis type II, an X-linked recessive disorder is the most common lysosomal storage disease detected among Filipinos. This is a case series involving 23 male Filipino patients confirmed to have Hunter syndrome. The clinical and biochemical characteristics were obtained and mutation testing of the IDS gene was done on the probands and their female relatives. RESULTS: The mean age of the patients was 11.28 (SD 4.10) years with an average symptom onset at 1...
January 11, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28076761/timing-is-everything
#10
Anna Mae Diehl
In a recent issue of Cancer Cell, Kettner and colleagues (2016) link disruption of normal circadian rhythms to NASH and associated liver cancer, suggesting that molecular clocks, as well as their regulators and target genes, might provide novel therapeutic targets in these diseases.
January 10, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28076255/problem-drug-related-behavior-and-discontinuation-of-opioids-following-the-introduction-of-an-opioid-management-program
#11
Lucinda A Grande, Ellen Campbell Thompson, Margaret A Au, Devin Sawyer, Laura-Mae Baldwin, Roger Rosenblatt
PURPOSE: Problem drug-related behavior (PDB) among patients on chronic opioid therapy may reflect an opioid use disorder. This study assessed PDB prevalence and the relationship between PDB and ongoing prescription of opioids at a primary care clinic that implemented a multifaceted opioid management program. METHODS: A chart review of patients in a chronic opioid registry assessed prevalence of different types of PDB over 2 years, and whether opioids were prescribed during the last 3 months of the 2-year study period among patients with different levels of PDB...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28074528/respiratory-motion-prediction-and-prospective-correction-for-free-breathing-arterial-spin-labeled-perfusion-mri-of-the-kidneys
#12
Hao Song, Dan Ruan, Wenyang Liu, V Andrew Stenger, Rolf Pohmann, Maria A Fernandez Seara, Tejas Nair, Sungkyu Jung, Jingqin Luo, Yuichi Motai, Jingfei Ma, John D Hazle, H Michael Gach
PURPOSE: Respiratory motion prediction using an artificial neural network (ANN) was integrated with pseudocontinuous arterial spin labeling (pCASL) MRI to allow free-breathing perfusion measurements in the kidney. In this study, we evaluated the performance of the ANN to accurately predict the location of the kidneys during image acquisition. METHODS: A pencil-beam navigator was integrated with a pCASL sequence to measure lung/diaphragm motion during ANN training and the pCASL transit delay...
January 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28071008/microwave-assisted-extraction-of-phenolic-compounds-from-polygonum-multiflorum-thunb-roots
#13
Le Pham Tan Quoc, Nguyen Van Muoi
BACKGROUND: The aim of this study was to determine the best extraction conditions for total phenolic content (TPC) and antioxidant capacity (AC) of Polygonum multiflorum Thunb. root using microwave-assisted extraction (MAE). METHODS: The raw material used was Polygonum multiflorum Thunb. root powder. Five factors such as solvent type, solvent concentrations, solvent/material ratio, extraction time and microwave power were studied; TPC and AC values were determined by the Folin-Ciocalteu method and DPPH free radical scavenging activity measurement, respectively...
April 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28069176/revisiting-the-progesterone-to-oocyte-ratio
#14
Micah J Hill, Mae Wu Healy, Kevin S Richter, Eric Widra, Eric D Levens, Alan H DeCherney, George Patounakis, Brian W Whitcomb
OBJECTIVE: To critically evaluate the P to oocyte (O) ratio (P/O) in the prediction of live birth in assisted reproductive technology (ART) cycles. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 7,608 fresh autologous ART ET cycles. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth. RESULT(S): Generalized estimating equation (GEE) models and receiver operating characteristic curves assessed the ability of P, O, and the P/O ratio to predict live birth...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28069014/cultural-elements-underlying-the-community-health-representative-client-relationship-on-navajo-nation
#15
Vikas Gampa, Casey Smith, Olivia Muskett, Caroline King, Hannah Sehn, Jamy Malone, Cameron Curley, Chris Brown, Mae-Gilene Begay, Sonya Shin, Adrianne Katrina Nelson
BACKGROUND: Navajo Nation Community Health Representatives (CHR) are trained community health workers (CHWs) who provide crucial services for patients and families. The success of the CHRs' interventions depends on the interactions between the CHRs and their clients. This research investigates the culturally specific factors that build and sustain the CHR-client interaction. METHODS: In-depth interviews were conducted with 16 CHRs on Navajo Nation. Interviews were transcribed and coded according to relevant themes...
January 9, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28064355/population-pharmacokinetic-models-of-lamotrigine-in-different-age-groups-of-chinese-children-with-epilepsy
#16
Zhong-Bin Zhang, Shuang-Min Ji, Ying Han, Li-Li Zang, Ying-Hui Wang, Wei Lu, Li Wang, Ye Wu
PURPOSE: The study aims to establish population pharmacokinetic (PPK) models of lamotrigine (LTG) in different age groups of epileptic children by nonlinear mixed effect modelling(NONMEM), and provide essential tools and theoretical basis for individualised optimal drug dose. METHODS: Cases of 473 epileptic children were divided into infant, toddler and preschool age (≤6 years) (n = 211), school age (6-12 years) (n = 171) and adolescence age (>12 years) (n = 81)...
January 7, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28064040/bax-to-basics-how-the-bcl2-gene-family-controls-the-death-of-retinal-ganglion-cells
#17
REVIEW
Margaret E Maes, Cassandra L Schlamp, Robert W Nickells
Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve. For several decades, we have understood that the RGC death process was executed by apoptosis, suggesting that there may be ways to therapeutically intervene in this cell death program and provide a more direct treatment to the cells and tissues affected in diseases like glaucoma. A major part of this endeavor has been to elucidate the molecular biological pathways active in RGCs from the point of axonal injury to the point of irreversible cell death...
January 4, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28062816/primary-care-clinic-re-design-for-prescription-opioid-management
#18
Michael L Parchman, Michael Von Korff, Laura-Mae Baldwin, Mark Stephens, Brooke Ike, DeAnn Cromp, Clarissa Hsu, Ed H Wagner
BACKGROUND: The challenge of responding to prescription opioid overuse within the United States has fallen disproportionately on the primary care clinic setting. Here we describe a framework comprised of 6 Building Blocks to guide efforts within this setting to address the use of opioids for chronic pain. METHODS: Investigators conducted site visits to thirty primary care clinics across the United States selected for their use of team-based workforce innovations...
January 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28062725/capacitive-water-release-and-internal-leaf-water-relocation-delay-drought-induced-cavitation-in-african-maesopsis-eminii
#19
Jackie Epila, Niels J F De Baerdemaeker, Lidewei L Vergeynst, Wouter H Maes, Hans Beeckman, Kathy Steppe
The impact of drought on the hydraulic functioning of important African tree species, like Maesopsis eminii Engl., is poorly understood. To map the hydraulic response to drought-induced cavitation, sole reliance on the water potential at which 50% loss of xylem hydraulic conductivity (ψ50) occurs might be limiting and at times misleading as the value alone does not give a comprehensive overview of strategies evoked by M. eminii to cope with drought. This article therefore uses a methodological framework to study the different aspects of drought-induced cavitation and water relations in M...
January 5, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28062458/hyperosmotic-agents-and-antibiotics-affect-dissolved-oxygen-and-ph-concentration-gradients-in-staphylococcus-aureus-biofilms
#20
Mia Mae Kiamco, Erhan Atci, Abdelrhman Mohamed, Douglas R Call, Haluk Beyenal
: Biofilms on wound surfaces are treated topically with hyperosmotic agents such as medical-grade honey and cadexomer iodine; in some cases, these treatments are combined with antibiotics. Tissue repair requires oxygen, and a low pH is conducive to oxygen release from red blood cells and epithelialization. We investigated the variation of dissolved oxygen concentration and pH with biofilm depth, and the variation in oxygen consumption rates when biofilms are challenged with medical-grade honey or cadexomer iodine combined with vancomycin or ciprofloxacin...
January 6, 2017: Applied and Environmental Microbiology
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