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https://www.readbyqxmd.com/read/29244902/feasibility-of-predicting-tumor-motion-using-online-data-acquired-during-treatment-and-a-generalized-neural-network-optimized-with-offline-patient-tumor-trajectories
#1
Troy Teo, Syed Bilal Ahmed, Nadia Alayoubi, Neil Bruce, Ethan Lyn, Stephen Pistorius
PURPOSE: The accurate prediction of intra-fraction lung tumor motion is required to compensate for system latency in image-guided adaptive radiotherapy systems. The goal of this study was to identify an optimal prediction model that has a short learning period so that prediction and adaptation can commence soon after treatment begins, and requires minimal re-optimization for individual patients. Specifically, the feasibility of predicting tumor position using a combination of a generalized (i...
December 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/29244693/bilateral-simultaneous-femoral-neck-stress-fracture-despite-clinical-recovery-from-anorexia-nervosa-a-case-report
#2
Jacques Hernigou, Simon Koulischer, Renaud Maes
CASE: A 38-year-old woman who had returned to sports activity (running) after having clinically recovered from anorexia nervosa presented with a bilateral femoral neck stress fracture that was treated with bilateral hip osteosynthesis. CONCLUSION: Although exercise is usually considered to be beneficial for health, heavy exercise (such as running) after recovery from anorexia nervosa may be associated with an increased risk of fracture.
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29239901/prevention-of-hiv-1-transmission-through-breastfeeding-efficacy-and-safety-of-maternal-antiretroviral-therapy-versus-infant-nevirapine-prophylaxis-for-duration-of-breastfeeding-in-hiv-1-infected-women-with-high-cd4-cell-count-impaact-promise-a-randomized-open
#3
Patricia M Flynn, Taha E Taha, Mae Cababasay, Mary Glenn Fowler, Lynne M Mofenson, Maxensia Owor, Susan Fiscus, Lynda Stranix-Chibanda, Anna Coutsoudis, Devasena Gnanashanmugam, Nahida Chakhtoura, Katie McCarthy, Cornelius Mukuzunga, Bonus Makanani, Dhayendre Moodley, Teacler Nematadzira, Bangini Kusakara, Sandesh Patil, Tichaona Vhembo, Raziya Bobat, Blandina T Mmbaga, Maysseb Masenya, Mandisa Nyati, Gerhard Theron, Helen Mulenga, Kevin Butler, David E Shapiro
BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in sub-Saharan Africa and India. METHODS: A randomized, open label strategy trial was conducted in HIV-1-infected women with CD4 counts >350 cells/mm (or >country-specific ART threshold if higher) and their breastfeeding HIV-1-uninfected newborns...
December 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29238950/age-estimation-in-older-adults-use-of-pulp-tooth-ratios-calculated-from-tooth-sections
#4
Lori D'Ortenzio, Tracy Prowse, Michael Inskip, Bonnie Kahlon, Megan Brickley
OBJECTIVES: Accurate age estimates are foundational for bioarchaeological research, yet the ability to accurately age older adult skeletons remains elusive. This study uses a new version of pulp/tooth area calculations to investigate chronological age of older archaeological individuals. MATERIALS AND METHODS: Pulp/tooth area ratios were calculated on modern control teeth (n = 10) that were first radiographed and then sectioned for comparative analysis. Pulp/tooth area ratios were determined on sectioned teeth using ImageJ software for: (a) modern individuals of known age (n = 26); (b) individuals from Belleville, Ontario, Canada (1821-1874) with documented age (n = 50); and (c) Belleville individuals with skeletally estimated age (n = 122)...
December 14, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29236563/feasibility-of-a-modified-ride-on-car-intervention-on-play-behaviors-during-an-inclusive-playgroup
#5
Samantha Mae Ross, Michele Catena, Erica Twardzik, Christina Hospodar, Erika Cook, Apoorva Ayyagari, Kelsey Inskeep, Bethany Sloane, Megan M MacDonald, Samuel W Logan
AIMS: Children with mobility related disabilities often experience limited participation and access to social interactions. An emerging pediatric powered mobility device are modified ride-on cars that provide self-directed mobility experiences to children with disabilities. This study aimed to determine: (1) the feasibility of a modified ride-on car intervention during an inclusive playgroup, (2) the effect of a modified ride-on car intervention on the play behaviors of children with and without mobility related disabilities...
December 13, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/29236329/predicting-the-bioavailability-of-sediment-bound-uranium-to-the-freshwater-midge-chironomus-dilutus-using-physicochemical-properties
#6
Sarah E Crawford, Stephen Lofts, Karsten Liber
Assessment of uranium (U)-contaminated sediment is often hindered by the inability to accurately account for the physicochemical properties of sediment that modify U bioavailability. The goal of this research was to determine whether sediment-associated U bioavailability could be predicted over a wide range of conditions and sediment properties using simple regressions and a geochemical speciation model, the Windermere Humic Aqueous Model (WHAM7). Data from U-contaminated field sediment bioaccumulation tests, along with previously published bioaccumulation studies with U-spiked field and formulated sediments were used to examine the models...
December 13, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29232871/thin-film-quantum-dot-photodiode-for-monolithic-infrared-image-sensors
#7
Pawel E Malinowski, Epimitheas Georgitzikis, Jorick Maes, Ioanna Vamvaka, Fortunato Frazzica, Jan Van Olmen, Piet De Moor, Paul Heremans, Zeger Hens, David Cheyns
Imaging in the infrared wavelength range has been fundamental in scientific, military and surveillance applications. Currently, it is a crucial enabler of new industries such as autonomous mobility (for obstacle detection), augmented reality (for eye tracking) and biometrics. Ubiquitous deployment of infrared cameras (on a scale similar to visible cameras) is however prevented by high manufacturing cost and low resolution related to the need of using image sensors based on flip-chip hybridization. One way to enable monolithic integration is by replacing expensive, small-scale III-V-based detector chips with narrow bandgap thin-films compatible with 8- and 12-inch full-wafer processing...
December 10, 2017: Sensors
https://www.readbyqxmd.com/read/29232509/evidence-for-nonstomatal-uptake-of-hg-by-aspen-and-translocation-of-hg-from-foliage-to-tree-rings-in-austrian-pine
#8
Jennifer Arnold, Mae Sexauer Gustin, Peter Weisberg
To determine whether trees are reliable biomonitors of air mercury (Hg) pollution concentrations were measured in bark, foliage, and tree rings. Data were developed using 4-year old Pinus and Populus trees grown from common genetic stock in Oregon and subsequently transferred to four air treatments differing in gaseous oxidized mercury (GOM) chemistry and total gaseous Hg (TGM) concentrations. Soil of a subset of trees was spiked with HgBr2 in solution to test for root uptake. Results indicate no significant effect of the soil spike or GOM compounds on tree tissue Hg concentrations...
December 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29231908/conjugated-polymer-nanoparticles-for-bioimaging
#9
REVIEW
Yasmine Braeken, Srujan Cheruku, Anitha Ethirajan, Wouter Maes
During the last decade, conjugated polymers have emerged as an interesting class of fluorescence imaging probes since they generally show high fluorescence brightness, high photostability, fast emission rates, non-blinking behavior and low cytotoxicity. The main concern related to most conjugated polymers is their lack of hydrophilicity and thereby poor bio-availability. This can, however, be overcome by the formulation of conjugated polymer nanoparticles in aqueous medium. This review provides an overview of the different techniques employed for the preparation of conjugated polymer nanoparticles, together with methods to improve their photoluminescence quantum yields...
December 12, 2017: Materials
https://www.readbyqxmd.com/read/29228946/a-school-based-intervention-improved-dietary-intake-outcomes-and-reduced-waist-circumference-in-adolescents-a-cluster-randomized-controlled-trial
#10
Angélica Ochoa-Avilés, Roosmarijn Verstraeten, Lieven Huybregts, Susana Andrade, John Van Camp, Silvana Donoso, Patricia Liliana Ramírez, Carl Lachat, Lea Maes, Patrick Kolsteren
BACKGROUND: In Ecuador, adolescents' food intake does not comply with guidelines for a healthy diet. Together with abdominal obesity adolescent's inadequate diets are risk factors for non-communicable diseases. We report the effectiveness of a school-based intervention on the dietary intake and waist circumference among Ecuadorian adolescents. METHODS: A pair-matched cluster randomized controlled trial including 1430 adolescents (12-14 years old) was conducted...
December 11, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29225688/repurposing-drugs-in-oncology-redo-chloroquine-and-hydroxychloroquine-as-anti-cancer-agents
#11
Ciska Verbaanderd, Hannelore Maes, Marco B Schaaf, Vikas P Sukhatme, Pan Pantziarka, Vidula Sukhatme, Patrizia Agostinis, Gauthier Bouche
Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer. Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they are able to sensitise tumour cells to a variety of drugs, potentiating the therapeutic activity. Thus far, clinical results are mostly in favour of the repurposing of CQ. However, over 30 clinical studies are still evaluating the activity of both CQ and HCQ in different cancer types and in combination with various standard treatments...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29225439/exploring-the-obesity-paradox-as-a-correlate-of-cognitive-and-physical-function-in-community-dwelling-black-and-white-older-adults
#12
Jeannine S Skinner, Willie Mae Abel, Katryna McCoy, Consuelo H Wilkins
Objective: The obesity paradox has been documented in aged populations, yet it remains unclear if this paradox persists for physical and cognitive outcomes in community-dwelling older adult populations. Our study examines associations between body mass index (BMI) classification, cognitive function, and physical function. We also investigate whether these associations are modified by race or age. Design: Cross-sectional study. Setting: Senior residential sites and community centers in Saint Louis, Missouri...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29224930/transport-of-dissolved-organic-matter-in-boom-clay-size-effects
#13
D Durce, M Aertsens, D Jacques, N Maes, M Van Gompel
A coupled experimental-modelling approach was developed to evaluate the effects of molecular weight (MW) of dissolved organic matter (DOM) on its transport through intact Boom Clay (BC) samples. Natural DOM was sampled in-situ in the BC layer. Transport was investigated with percolation experiments on 1.5cm BC samples by measuring the outflow MW distribution (MWD) by size exclusion chromatography (SEC). A one-dimensional reactive transport model was developed to account for retardation, diffusion and entrapment (attachment and/or straining) of DOM...
December 5, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29222512/improving-gene-regulatory-network-inference-by-incorporating-rates-of-transcriptional-changes
#14
Jigar S Desai, Ryan C Sartor, Lovely Mae Lawas, S V Krishna Jagadish, Colleen J Doherty
Organisms respond to changes in their environment through transcriptional regulatory networks (TRNs). The regulatory hierarchy of these networks can be inferred from expression data. Computational approaches to identify TRNs can be applied in any species where quality RNA can be acquired, However, ChIP-Seq and similar validation methods are challenging to employ in non-model species. Improving the accuracy of computational inference methods can significantly reduce the cost and time of subsequent validation experiments...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29216167/time-reflection-and-refraction-of-graphene-plasmons-at-a-temporal-discontinuity
#15
Galaad Altares Menendez, Bjorn Maes
A dynamical change of material properties induces a special type of reflection and refraction at a temporal discontinuity. Here, we study the interaction of graphene plasmons with single and double temporal discontinuities or shocks, leading to controlled in-plane scattering. We analytically determine the Fresnel-like coefficients for graphene plasmons at these boundaries, and validate our results by rigorous numerical simulations. Temporally controlled doping of two-dimensional materials such as graphene thus leads to a new mechanism for planar and compact plasmonic devices...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29214876/assessing-the-risk-of-cardiac-toxicity-after-contemporary-treatment-for-hodgkin-lymphoma-a-systematic-review
#16
Julie Fu, Jenica Upshaw, Joshua Cohen, Angie Mae Rodday, Tully Saunders, Michael Kelly, Andrew M Evens, Susan K Parsons
No abstract text is available yet for this article.
December 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29207388/resveratrol-does-not-protect-from-ischemia-induced-acute-kidney-injury-in-an-in-vivo-rat-model
#17
Anja Bienholz, Rahel Mae Pang, Hana Guberina, Ursula Rauen, Oliver Witzke, Benjamin Wilde, Frank Petrat, Thorsten Feldkamp, Andreas Kribben
BACKGROUND/AIMS: The natural polyphenol resveratrol (RSV) has been shown to ameliorate ischemia/reperfusion (I/R)-induced damage. Therefore, a rat model of I/R-induced AKI equipped with intensive monitoring was utilized to examine direct renal protection by RSV in vivo. METHODS: AKI was induced by bilateral renal clamping (45 min) followed by reperfusion (3 h). Solvent-free RSV was continuously infused intravenously (0.056 and 0.28 mg/kg) in a total volume of 7 ml/kg/h starting from 30 min before renal clamping...
December 5, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29206850/the-prognostic-value-of-asymmetric-dimethylarginine-in-patients-with-cardiac-syndrome-x
#18
Tse-Min Lu, Tzong-Shyuan Lee, Shing-Jong Lin, Wan-Leong Chan, Chiao-Po Hsu
BACKGROUND: The pathophysiology of cardiac syndrome X is multifactorial and endothelial dysfunction has been implicated as important contributing factor. Asymmetric dimethylarginine (ADMA), characterized as a circulating endogenous inhibitor of nitric oxide synthase, may have been implicated as an important contributing factor for the development of endothelial dysfunction. In this study, we aim to assess the predictive power of ADMA for long-term prognosis in patients with cardiac syndrome X...
2017: PloS One
https://www.readbyqxmd.com/read/29204649/aav2-mediated-transduction-of-the-mouse-retina-after-optic-nerve-injury
#19
Robert W Nickells, Heather M Schmitt, Margaret E Maes, Cassandra L Schlamp
Purpose: Gene therapy of retinal ganglion cells (RGCs) has promise as a powerful therapeutic for the rescue and regeneration of these cells after optic nerve damage. However, early after damage, RGCs undergo atrophic changes, including gene silencing. It is not known if these changes will deleteriously affect transduction and transgene expression, or if the therapeutic protein can influence reactivation of the endogenous genome. Methods: Double-transgenic mice carrying a Rosa26-(LoxP)-tdTomato reporter, and a mutant allele for the proapoptotic Bax gene were reared...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29198027/estimation-of-sodium-adsorption-ratio-indicator-using-data-mining-methods-a-case-study-in-urmia-lake-basin-iran
#20
Mohammad Taghi Sattari, Arya Farkhondeh, John Patrick Abraham
Water quality is a major concern around the world, particularly in dry climates. Usually, assessment of surface water quality is costly and time-consuming. In this situation, a method which could estimate the water quality accurately with the minimum of hydro-chemical parameters would be appealing. In this study, three data mining methods, namely, M5 model tree, support vector machine (SVM), and Gaussian process (GP), were employed to estimate the sodium adsorption ratio (SAR) indicator in the Shahrchay River located in the west of the Urmia Lake basin, Iran...
December 2, 2017: Environmental Science and Pollution Research International
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