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Child respiratory disease

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https://www.readbyqxmd.com/read/29627169/side-effects-of-medications-used-to-treat-childhood-interstitial-lung-disease
#1
REVIEW
Oded Breuer, André Schultz
Interstitial lung disease in children (chILD) comprises a range of different rare diseases. There is limited evidence for the treatment of chILD and no randomised clinical trials of treatment have been undertaken. Most treatments are therefore prescribed off-label based on expert opinion. The off-label nature of prescription of drugs for chILD highlights the importance of a solid understanding of the side effects to facilitate risk-benefit assessment. The European Respiratory Society chILD guidelines recommend the use of systemic glucocorticosteroids, hydroxychloroquine and azithromycin...
March 17, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29619212/validity-of-maternal-report-of-care-seeking-for-childhood-illness
#2
Emily D Carter, Micky Ndhlovu, Melinda Munos, Emmy Nkhama, Joanne Katz, Thomas P Eisele
Background: Accurate data on care-seeking for child illness are needed to improve public health programs and reduce child mortality. The accuracy of maternal report of care-seeking for child illness as collected through household surveys has not been validated. Methods: A 2016 survey compared reported care-seeking against a gold-standard of health care provider documented care-seeking events among a random sample of mothers of children <5 years in Southern Province, Zambia...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29616610/a-case-of-respiratory-toxigenic-diphtheria-contact-tracing-results-and-considerations-following-a-30-year-disease-free-interval-catalonia-spain-2015
#3
Mireia Jané, Maria José Vidal, Neus Camps, Magda Campins, Ana Martínez, Joan Balcells, Maria Teresa Martin-Gomez, Gloria Bassets, Silvia Herrera-León, Anton Foguet, Mar Maresma, Nuria Follia, Sonia Uriona, Tomàs Pumarola
In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae . After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but died at the end of June. Two hundred and seventeen contacts were identified in relation to the index case, and their vaccination statuses were analysed, updated and completed. Of these, 140 contacts underwent physical examination and throat swabs were taken from them for analysis...
March 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29605429/dysfunction-of-nav1-4-a-skeletal-muscle-voltage-gated-sodium-channel-in-sudden-infant-death-syndrome-a-case-control-study
#4
Roope Männikkö, Leonie Wong, David J Tester, Michael G Thor, Richa Sud, Dimitri M Kullmann, Mary G Sweeney, Costin Leu, Sanjay M Sisodiya, David R FitzPatrick, Margaret J Evans, Iona J M Jeffrey, Jacob Tfelt-Hansen, Marta C Cohen, Peter J Fleming, Amie Jaye, Michael A Simpson, Michael J Ackerman, Michael G Hanna, Elijah R Behr, Emma Matthews
BACKGROUND: Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant death in high-income countries. Central respiratory system dysfunction seems to contribute to these deaths. Excitation that drives contraction of skeletal respiratory muscles is controlled by the sodium channel NaV1.4, which is encoded by the gene SCN4A. Variants in NaV1.4 that directly alter skeletal muscle excitability can cause myotonia, periodic paralysis, congenital myopathy, and myasthenic syndrome...
March 28, 2018: Lancet
https://www.readbyqxmd.com/read/29602647/bronchiectasis-chronic-suppurative-lung-disease-and-protracted-bacterial-bronchitis
#5
Dan T Benscoter
Bronchiectasis is a structural airway disease characterized by dilated bronchi and bronchioles due to severe or recurrent lower airways inflammation. Bronchiectasis can occur as a result of chronic pulmonary aspiration. Bronchiectasis may also be associated with a wide variety of systemic diseases, which should be considered in the differential diagnosis. Children with bronchiectasis typically have a chronic or recurrent productive cough and carry a significant burden of disease with a considerable impact on quality of life...
March 27, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29577380/the-effect-of-medical-and-operative-birth-interventions-on-child-health-outcomes-in-the-first-28-days-and-up-to-5-years-of-age-a-linked-data-population-based-cohort-study
#6
Lilian L Peters, Charlene Thornton, Ank de Jonge, Ali Khashan, Mark Tracy, Soo Downe, Esther I Feijen-de Jong, Hannah G Dahlen
BACKGROUND: Spontaneous vaginal birth rates are decreasing worldwide, while cesarean delivery, instrumental births, and medical birth interventions are increasing. Emerging evidence suggests that birth interventions may have an effect on children's health. Therefore, the aim of our study was to examine the association between operative and medical birth interventions on the child's health during the first 28 days and up to 5 years of age. METHODS: In New South Wales (Australia), population-linked data sets were analyzed, including data on maternal characteristics, child characteristics, mode of birth, interventions during labor and birth, and adverse health outcomes of the children (ie, jaundice, feeding problems, hypothermia, asthma, respiratory infections, gastrointestinal disorders, other infections, metabolic disorder, and eczema) registered with the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes...
March 25, 2018: Birth
https://www.readbyqxmd.com/read/29572587/neonatal-abstinence-syndrome-nas-in-southwestern-border-states-examining-trends-population-correlates-and-implications-for-policy
#7
Khaleel S Hussaini, Luigi F Garcia Saavedra
Introduction Neonatal abstinence syndrome (NAS) is withdrawal syndrome in newborns following birth and is primarily caused by maternal drug use during pregnancy. This study examines trends, population correlates, and policy implications of NAS in two Southwest border states. Materials and Methods A cross-sectional analysis of Hospital Inpatient Discharge Data (HIDD) was utilized to examine the incidence of NAS in the Southwest border states of Arizona (AZ) and New Mexico (NM). All inpatient hospital births in AZ and NM from January 1, 2008 through December 31, 2013 with ICD9-CM codes for NAS (779...
March 23, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29569250/impact-of-upper-respiratory-tract-infections-on-perioperative-outcomes-of-children-undergoing-therapeutic-cardiac-catheterisation
#8
S Zhang, S Ding, M Cai, J Bai, M Zhang, Y Huang, J Zheng
BACKGROUND: Recent upper respiratory tract infection (URI) is associated with increased incidence of perioperative complications in children undergoing open heart surgery. As a result, surgery is often postponed. However, the effect of recent URI on the incidence of perioperative complications in children undergoing therapeutic cardiac catheterisation is unknown. We investigated the perioperative outcomes of congenital heart disease (CHD) children with recent URI who underwent elective therapeutic catheterisation...
March 22, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29559280/adherence-to-pharmacotherapy-improves-school-performance-in-children-with-rhinitis-and-asthma
#9
J Sánchez, A Sánchez, R Cardona
BACKGROUND: Adherence to pharmacotherapy reduces symptoms of asthma and rhinitis, however, little is known of its impact on school performance. OBJECTIVE: To evaluate the impact of pharmacotherapy in absenteeism and school performance in a child population. METHODS: A cross-sectional study, carried out in eight schools. All participants and their parents were given a questionnaire assessing parameters related to respiratory diseases and pharmacotherapy...
March 17, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29557569/does-forest-loss-increase-human-disease-evidence-from-nigeria
#10
Julia Berazneva, Tanya S. Byker
It is estimated that about one quarter of the global disease burden in terms of healthy life years lost and about one quarter of all premature deaths can be attributed to modifiable environmental factors (Pruss-Ustun and Corvalan 2006). Three infectious diseases--diarrhea, respiratory infections, and malaria--account for the largest absolute burden in developing countries with children facing the greatest impacts. There is a growing body of evidence demonstrating the health burden of air and water pollution, as well as important productivity and income effects (see, for example, reviews of the literature in Pattanayak and Pfaff 2009 and Greenstone and Jack 2016)...
May 2017: American Economic Review
https://www.readbyqxmd.com/read/29556256/spinal-muscular-atrophy-type-i-and-the-dual-role-of-viruses-an-interview-with-professor-basil-t-darras-professor-of-neurology-pediatrics-at-harvard-medical-school
#11
Ioannis N Mammas, Demetrios A Spandidos
According to Professor Basil T. Darras, Professor of Neurology (Pediatrics) at Harvard Medical School and Director of the Spinal Muscular Atrophy (SMA) Program at Boston Children's Hospital in Boston (MA, USA), the diagnosis of SMA type I is clinical and is based on detailed general physical and neurological examinations. SMA type I remains the most common genetic disease resulting in death in infancy and is really devastating for the child, the parents, as well as the medical professionals with the privilege of caring for patients with SMA and their parents...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29550712/associations-of-prenatal-environmental-phenol-and-phthalate-biomarkers-with-respiratory-and-allergic-diseases-among-children-aged-6-and-7-years
#12
Jessie P Buckley, Lesliam Quirós-Alcalá, Susan L Teitelbaum, Antonia M Calafat, Mary S Wolff, Stephanie M Engel
BACKGROUND: Prenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease. OBJECTIVES: We estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study. METHODS: We quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations)...
March 15, 2018: Environment International
https://www.readbyqxmd.com/read/29517585/genetic-causes-and-clinical-management-of-pediatric-interstitial-lung-diseases
#13
Nadia Nathan, Keren Borensztajn, Annick Clement
PURPOSE OF REVIEW: Interstitial lung disease (ILD) in children (chILD) is an umbrella term for a heterogeneous group of rare respiratory disorders that are mostly chronic and associated with high morbidity and mortality. The pathogenesis of the various chILD is complex and implicates genetic contributors. The purpose of this review is to provide updated information on the molecular defects associated with the development of chILD. RECENT FINDINGS: Currently, the main mutations are identified in the surfactant genes SFTPA1, SFTPA2, SFTPB, SFTPC, ABCA3, and NKX2-1...
May 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29509866/association-between-estimated-cumulative-vaccine-antigen-exposure-through-the-first-23-months-of-life-and-non-vaccine-targeted-infections-from-24-through-47-months-of-age
#14
Jason M Glanz, Sophia R Newcomer, Matthew F Daley, Frank DeStefano, Holly C Groom, Michael L Jackson, Bruno J Lewin, Natalie L McCarthy, David L McClure, Komal J Narwaney, James D Nordin, Ousseny Zerbo
Importance: Some parents are concerned that multiple vaccines in early childhood could weaken their child's immune system. Biological data suggest that increased vaccine antigen exposure could increase the risk for infections not targeted by vaccines. Objective: To examine estimated cumulative vaccine antigen exposure through the first 23 months of life in children with and without non-vaccine-targeted infections from 24 through 47 months of age. Design, Setting, and Participants: A nested case-control study was conducted in 6 US health care organizations participating in the Vaccine Safety Datalink...
March 6, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29507601/the-annual-cost-of-not-breastfeeding-in-indonesia-the-economic-burden-of-treating-diarrhea-and-respiratory-disease-among-children-24mo-due-to-not-breastfeeding-according-to-recommendation
#15
Adiatma Y M Siregar, Pipit Pitriyan, Dylan Walters
Background: In Indonesia, 96% of children (< 24mo) are breastfed. However, only 42% of children (< 6mo) are exclusively breastfed, as per World Health Organization recommendations. Breastfeeding provides protective benefits such as reducing the risk of morbidity and mortality associated with diarrhea and pneumonia/respiratory disease (PRD). This study estimates the potential economic impact of not breastfeeding according to recommendation in Indonesia based on infants suffering from attributable diarrhea and PRD...
2018: International Breastfeeding Journal
https://www.readbyqxmd.com/read/29506511/hospital-readmissions-with-acute-infectious-diseases-in-new-zealand-children-2-years-of-age
#16
Silvia Seibt, Catherine A Gilchrist, Peter W Reed, Emma J Best, Anthony Harnden, Carlos A Camargo, Cameron C Grant
BACKGROUND: Infectious diseases are the leading cause of hospital admissions in young children. Hospitalisation with an infectious disease is a recurrent event for some children. Our objective was to describe risk factors for infectious disease readmission following hospital admission with an infectious disease in the first two years of life. METHODS: We performed a national cohort study of New Zealand children, born 2005-2009, with an infectious disease admission before age 24 months...
March 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29501408/fazio-londe-syndrome-in-siblings-from-india-with-different-phenotypes
#17
Vykuntaraju K Gowda, Tamilarasan Udhayabanu, Perumal Varalakshmi, Varunvenkat M Srinivasan, Balasubramaniem Ashokkumar
BACKGROUND: Fazio-Londe syndrome also called progressive bulbar palsy of childhood is a very rare motor neuron disease of pediatric age group characterized by progressive paralysis of lower cranial nerves. OBJECTIVE: To describe Fazio-Londe syndrome in sibling with different phenotype. METHODS: A 6 years old female child presented with inability to close eyes, difficulty in swallowing, respiratory muscle weakness and voice change since 5 yr of age...
February 28, 2018: Brain & Development
https://www.readbyqxmd.com/read/29501252/pulmonary-function-in-former-very-low-birth-weight-preterm-infants-in-the-first-year-of-life
#18
Daniela de Melo Miranda Gonçalves, Gustavo Falbo Wandalsen, Ana Sílvia Scavacini, Fernanda Cordoba Lanza, Ana Lucia Goulart, Dirceu Solé, Amélia Miyashiro Nunes Dos Santos
BACKGROUND: Pulmonary function in former preterm infants may be compromised during childhood. OBJECTIVES: To assess pulmonary function in very-low-birth-weight preterm infants at 6-12 months of corrected age and analyze the factors associated with abnormal pulmonary function. METHODS: Cross-sectional study with preterm infants at 6-12 months of corrected age with birth weight <1500 g. Children with malformations or affected by neuromuscular and respiratory diseases were excluded...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29500783/examination-of-child-and-adolescent-hospital-admission-rates-in-queensland-australia-1995-2011-a-comparison-of-coal-seam-gas-coal-mining-and-rural-areas
#19
Angela K Werner, Kerrianne Watt, Cate Cameron, Sue Vink, Andrew Page, Paul Jagals
Objectives At present, coal seam gas (CSG) is the most common form of unconventional natural gas development occurring in Australia. Few studies have been conducted to explore the potential health impacts of CSG development on children and adolescents. This analysis presents age-specific hospitalisation rates for a child and adolescent cohort in three study areas in Queensland. Methods Three geographic areas were selected: a CSG area, a coal mining area, and a rural area with no mining activity. Changes in area-specific hospital admissions were investigated over the period 1995-2011 in a series of negative binomial regression analyses for 19 International Classification of Diseases (ICD) chapters, adjusting for sociodemographic factors...
March 2, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29491238/isolation-rate-of-neisseria-meningitidis-in-japanese-children-with-respiratory-tract-infections
#20
Haruka Takei, Naruhiko Ishiwada, Noriko Takeuchi, Misako Ohkusu, Tadashi Hoshino, Shota Murata, Hiroko Sato, Katsuaki Abe, Kenichi Shizuno, Haruka Hishiki, Naoki Shimojo
Although invasive meningococcal disease is rare in Japan (0.028 cases per 100,000 population), its incidence is 10 times greater in many other countries. Colonization is a prerequisite for invasive meningococcal disease. However, no study in Japan has specifically analysed the carriage rate of Neisseria meningitidis in children. During 5 months in 2015, the respiratory tract specimens of patients who presented to three hospitals with respiratory symptoms were cultured. The bacteria were identified in selective medium using a meningococcal detection kit and the serogroup was identified by polymerase chain reaction analysis...
February 28, 2018: Japanese Journal of Infectious Diseases
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