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Systematic review of ssi

F E E de Vries, S L Gans, J S Solomkin, B Allegranzi, M Egger, E P Dellinger, M A Boermeester
BACKGROUND: There is a clear association between hyperglycaemia and surgical-site infection (SSI). Intensive glucose control may involve a risk of hypoglycaemia, which in turn results in potentially severe complications. A systematic review was undertaken of studies comparing intensive versus conventional glucose control protocols in relation to reduction of SSI and other outcomes, including hypoglycaemia, mortality and stroke. METHODS: PubMed, Embase, CENTRAL, CINAHL and WHO databases from 1 January 1990 to 1 August 2015 were searched...
November 30, 2016: British Journal of Surgery
Benedetta Allegranzi, Peter Bischoff, Stijn de Jonge, N Zeynep Kubilay, Bassim Zayed, Stacey M Gomes, Mohamed Abbas, Jasper J Atema, Sarah Gans, Miranda van Rijen, Marja A Boermeester, Matthias Egger, Jan Kluytmans, Didier Pittet, Joseph S Solomkin
Surgical site infections (SSIs) are among the most preventable health-care-associated infections and are a substantial burden to health-care systems and service payers worldwide in terms of patient morbidity, mortality, and additional costs. SSI prevention is complex and requires the integration of a range of measures before, during, and after surgery. No international guidelines are available and inconsistencies in the interpretation of evidence and recommendations of national guidelines have been identified...
November 1, 2016: Lancet Infectious Diseases
Ngaroua, Joseph Eloundou Ngah, Thomas Bénet, Yaouba Djibrilla
INTRODUCTION: Surgical Site Infections (SSI) cause morbi-mortality and additional healthcare expenditures. Developing countries are the most affected. The objective was to estimate the pooled incidence of SSI in Sub-Saharan Africa and describe its major risk factors. METHODS: Systematic review and meta-analysis were conducted using the databases of the World Health Organization Regional Office for Africa, PubMed and standard search to select electronic articles published between 2006 and 2015...
2016: Pan African Medical Journal
Alessandro Cassini, Diamantis Plachouras, Tim Eckmanns, Muna Abu Sin, Hans-Peter Blank, Tanja Ducomble, Sebastian Haller, Thomas Harder, Anja Klingeberg, Madlen Sixtensson, Edward Velasco, Bettina Weiß, Piotr Kramarz, Dominique L Monnet, Mirjam E Kretzschmar, Carl Suetens
BACKGROUND: Estimating the burden of healthcare-associated infections (HAIs) compared to other communicable diseases is an ongoing challenge given the need for good quality data on the incidence of these infections and the involved comorbidities. Based on the methodology of the Burden of Communicable Diseases in Europe (BCoDE) project and 2011-2012 data from the European Centre for Disease Prevention and Control (ECDC) point prevalence survey (PPS) of HAIs and antimicrobial use in European acute care hospitals, we estimated the burden of six common HAIs...
October 2016: PLoS Medicine
Fleur E E De Vries, Elon D Wallert, Joseph S Solomkin, Benedetta Allegranzi, Matthias Egger, E Patchen Dellinger, Marja A Boermeester
OBJECTIVE: Systematically review and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) studies on prophylactic negative pressure wound therapy (pNPWT) to prevent surgical site infections (SSIs). INTRODUCTION: pNPWT has been suggested as a new method to prevent wound complications, specifically SSIs, by its application on closed incisional wounds. METHODS: This review was conducted as part of the development of the Global Guidelines for prevention of SSIs commissioned by World Health Organization in Geneva...
September 2016: Medicine (Baltimore)
E Erdas, F Medas, G Pisano, A Nicolosi, P G Calò
PURPOSE: A meta-analysis was performed to asses whether antibiotic prophylaxis is effective in reducing the incidence of surgical site infection (SSI) after open mesh repair of groin hernia. METHODS: A literature search for randomized controlled trials (RCT) evaluating the effectiveness of antibiotic prophylaxis in adult patients undergoing open mesh repair of groin hernia was performed in November 2015. Incidence of overall and deep SSI was considered as primary and secondary outcome measures, respectively...
December 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
X Wu, N Z Kubilay, J Ren, B Allegranzi, P Bischoff, B Zayed, D Pittet, J Li
To investigate the effectiveness of antimicrobial-coated sutures compared with non-coated sutures in reducing surgical site infection (SSI) and develop recommendations for World Health Organization (WHO) SSI prevention guidelines. We searched Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials, and WHO Global Health from 1990-16/02/2015 with language restricted to English, Spanish, and French. Meta-analysis was performed with a random-effects model. Meta-regression analysis assessed whether the effect of antimicrobial coating changed according to the type of suture and surgery...
September 2, 2016: European Journal of Clinical Microbiology & Infectious Diseases
Marta Sandini, Ilaria Mattavelli, Luca Nespoli, Fabio Uggeri, Luca Gianotti
BACKGROUND: Several randomized clinical trials (RCTs) conducted to evaluate the effect of triclosan-coated suture on surgical site infection (SSI) yield to controversial results. The primary purpose of this systematic review and meta-analysis was to analyze the available RCTs, comparing the effect of triclosan-coated suture with uncoated suture on the incidence of SSI after elective colorectal operations. As secondary endpoint of the analysis, we considered length of hospital stay after surgery...
August 2016: Medicine (Baltimore)
Stephanie Schipmann, Erol Akalin, Justin Doods, Christian Ewelt, Walter Stummer, Eric Jose Suero
BACKGROUND: In order to effectively avoid surgical site infections (SSIs) by identifying patients at high risk for infectious complications, a better understanding of relevant risk factors is required. This manuscript describes a matched case-control study of patients undergoing cranial neurosurgery with postoperative surgical site infections and a systematic literature review. METHODS: From January 2012 to March 2015, 70 cases (2.47%) with SSIs out of 2,819 patients, along with 185 controls were identified...
August 6, 2016: World Neurosurgery
Jerry D Brewer, Alexandra B Gonzalez, Christian L Baum, Christopher J Arpey, Randall K Roenigk, Clark C Otley, Patricia J Erwin
IMPORTANCE: Whether the use of sterile vs nonsterile gloves in outpatient cutaneous procedures affects the rate of postoperative wound infection is unknown. OBJECTIVE: To explore rates of surgical site infection (SSI) with the use of sterile vs nonsterile gloves in outpatient cutaneous surgical procedures. DATA SOURCES: This systematic review and meta-analysis identified studies from Ovid MEDLINE (1946 to present), Ovid Cochrane Central Register of Controlled Trials (1991 to present), Ovid EMBASE (1988 to present), EBSCO Cumulative Index to Nursing and Allied Health Literature (1980 to present), Scopus (1996 to present), and Web of Science (1975 to present)...
September 1, 2016: JAMA Dermatology
Nicholas Graves, Catherine Wloch, Jennie Wilson, Adrian Barnett, Alex Sutton, Nicola Cooper, Katharina Merollini, Victoria McCreanor, Qinglu Cheng, Edward Burn, Theresa Lamagni, Andre Charlett
BACKGROUND: A deep infection of the surgical site is reported in 0.7% of all cases of total hip arthroplasty (THA). This often leads to revision surgery that is invasive, painful and costly. A range of strategies is employed in NHS hospitals to reduce risk, yet no economic analysis has been undertaken to compare the value for money of competing prevention strategies. OBJECTIVES: To compare the costs and health benefits of strategies that reduce the risk of deep infection following THA in NHS hospitals...
July 2016: Health Technology Assessment: HTA
Erik Woelber, Emily J Schrick, Bradford D Gessner, Heather L Evans
BACKGROUND: Surgical site infection (SSI) is the most common type of healthcare-associated infection, contributing to substantial annual morbidity, costs, and deaths. In the United States it is the number one reason for hospital re-admission after surgery. Relatively little attention has been paid to the proportion of SSIs that occur after discharge. This paper systematically reviews two decades of publications to characterize better the proportion of SSIs that are identified after discharge and the need for better early detection and treatment...
October 2016: Surgical Infections
Edward W Swanson, Hsu-Tang Cheng, Srinivas M Susarla, Denver M Lough, Anand R Kumar
BACKGROUND: Despite advances in surgical technique, ventral hernia repair (VHR) remains associated with significant postoperative wound complications. OBJECTIVE: A systematic review and meta-analysis was performed to identify whether the application of negative pressure wound therapy to closed incisions (iNPWT) following VHR reduces the risk of postoperative wound complications and hernia recurrence. METHODS: The PubMed/MEDLINE, EMBASE and SCOPUS databases were searched for studies published through October 2015...
2016: Plastic Surgery
Susan George, A Renee Leasure, Douglas Horstmanshof
BACKGROUND: Surgical site infections (SSI) are a serious complication of surgery. Staphylococcus aureus (S aureus) is 1 of the most common causative organisms responsible for SSI. Patients who are carriers of methicillin-resistant S aureus and methicillin-sensitive S aureus are at increased risk of developing S aureus-associated SSIs. Decolonization of skin with chlorhexidine and nares with mupirocin may reduce the risk of SSI. OBJECTIVE: The primary object of this systematic review is to examine the effectiveness of preoperative universal decolonization of skin with chlorhexidine and nares with intranasal mupirocin in preventing SSIs...
July 2016: Dimensions of Critical Care Nursing: DCCN
Ashley Pritchard, Katie Donohue, Theresa Hyland, Cheryl Raab, Elizabeth Omara, Christian Pettker
INTRODUCTION: Postoperative surgical site infection (SSI) affects 8-14% of cesarean deliveries (CD), impacting approximately 175,000 births and costing over $600 million annually. The relatively high SSI occurrence may partly be attributable to the relative lack of standardization across Labor & Delivery operating rooms. This study aims to assess the impact of a multidisciplinary and stepwise quality improvement approach to collect best practices surrounding CD and to implement an evidence-based bundle of care to reduce post-operative SSI...
May 2016: Obstetrics and Gynecology
Chong Hyun Suh, Young Jun Choi, Jung Hwan Baek, Jeong Hyun Lee
OBJECTIVE: To evaluate the diagnostic performance of shear wave elastography for malignant cervical lymph nodes. METHODS: We searched the Ovid-MEDLINE and EMBASE databases for published studies regarding the use of shear wave elastography for diagnosing malignant cervical lymph nodes. The diagnostic performance of shear wave elastography was assessed using bivariate modelling and hierarchical summary receiver operating characteristic modelling. Meta-regression analysis and subgroup analysis according to acoustic radiation force impulse imaging (ARFI) and Supersonic shear imaging (SSI) were also performed...
January 2017: European Radiology
Rosa van Hoorn, Ernesto Jaramillo, David Collins, Agnes Gebhard, Susan van den Hof
BACKGROUND: There is uncertainty about the contribution that social support interventions (SSI) can have in mitigating the personal, social and economic costs of tuberculosis (TB) treatment on patients, and improving treatment outcomes. OBJECTIVE: To identify psycho-emotional (PE) and socio-economic (SE) interventions provided to TB patients and to assess the effects of these interventions on treatment adherence and treatment outcomes. SEARCH STRATEGY: We searched PubMed and Embase from 1 January 1990-15 March 2015 and abstracts of the Union World Conference on Lung Health from 2010-2014 for studies reporting TB treatment adherence and treatment outcomes following SSI...
2016: PloS One
Michael L Rinke, Dominique Jan, Janelle Nassim, Jaeun Choi, Steven J Choi
OBJECTIVE To identify surgical site infection (SSI) rates following pediatric ambulatory surgery, SSI outcomes and risk factors, and sensitivity and specificity of SSI administrative billing codes. DESIGN Retrospective chart review of pediatric ambulatory surgeries with International Classification of Disease, Ninth Revision (ICD-9) codes for SSI, and a systematic random sampling of 5% of surgeries without SSI ICD-9 codes, all adjudicated for SSI on the basis of an ambulatory-adapted National Healthcare Safety Network definition...
August 2016: Infection Control and Hospital Epidemiology
Marine Clay, Arnaud Mazouyes, Melanie Gilson, Philippe Gaudin, Athan Baillet
OBJECTIVE: To determine whether continuation of tumor necrosis factor inhibitors (TNFi) before surgery increases the risk of surgical site infection (SSI) in rheumatoid arthritis (RA) patients. METHODS: A systematic review of the literature was conducted from January 2000 to May first 2014, using the databases of PubMed, Cochrane review, Embase, and manual research of abstracts presented in scientific congresses. Most included studies were retrospective. We compared the risk of SSI in the case of discontinuation of TNFi versus continuing TNFi treatment before a surgery...
April 22, 2016: Joint, Bone, Spine: Revue du Rhumatisme
Patrick B O'Neal, Kamal M F Itani
BACKGROUND: A number of adjunct antimicrobial measures have been studied in an attempt to reduce surgical site infection (SSI) rates. In addition to parenteral antibiotic prophylaxis, these measures include oral antibiotics in bowel preparation for colorectal surgery, antiseptic/antimicrobial irrigation, antimicrobial sutures, local antibiotics, skin incision antibacterial sealants, and antimicrobial dressings. It is the purpose of this review to study the evidence behind each of these measures and to evaluate relevant data for recommendations in each area...
June 2016: Surgical Infections
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