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Shantanu N Razdan, Peter G Cordeiro, Claudia R Albornoz, Joseph J Disa, Hina J Panchal, Alice Y Ho, Adeyiza O Momoh, Evan Matros
Background Immediate breast reconstruction (IBR) is often deferred, when postmastectomy radiotherapy (PMRT) is anticipated, due to high complication rates. Nonetheless, because of robust data supporting improved health-related quality of life associated with reconstruction, physicians and patients may be more accepting of tradeoffs. The current study explores national trends of IBR utilization rates and methods in the setting of PMRT, using the National Cancer Database (NCDB). The study hypothesis is that prosthetic techniques have become the most common method of IBR in the setting of PMRT...
February 24, 2017: Journal of Reconstructive Microsurgery
Jun Yin, Jian Zhao, Weimin Hu, Guangping Yang, Hui Yu, Ruihao Wang, Linjing Wang, Guoqian Zhang, Wenfan Fu, Lu Dai, Wanzhen Li, Boyu Liao, Shuxu Zhang
Radio- and chemo-resistance represent major obstacles in the therapy of non-small-cell lung cancer (NSCLC) and the underlying molecular mechanisms are not known. In the present study, during induction of radio- or chemo-resistance in NSCLC cells, dynamic analyses revealed that decreased expression of let-7 induced by irradiation or cisplatin resulted in increased expression of its target gene LIN28, and increased expression of LIN28 then contributed to further decreased expression of let-7 by inhibiting its maturation and biogenesis...
2017: PloS One
C Honoré, V Atallah, O Mir, D Orbach, G Ferron, C LePéchoux, J B Delhorme, P Philippe-Chomette, S Sarnacki, S Msika, P Terrier, O Glehen, H Martelli, V Minard-Colin, F Bertucci, J Y Blay, S Bonvalot, D Elias, A LeCesne, P Sargos
BACKGROUND: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery (CCRS) remains unknown. METHODS: To identify patients with DSRCT without extraperitoneal metastases (EPM) who underwent CCRS between 1991 and 2015, a retrospective nation-wide survey was conducted by crossing the prospective and retrospective databases of the French Network for Rare Peritoneal Malignancies, French Reference Network in Sarcoma Pathology, French Sarcoma Clinical Network and French Pediatric Cancer Society...
2017: PloS One
Anirban Das, Indranil Mallick, Pattatheyil Arun, Divya Midha, Saugata Sen, Shekhar Krishnan, Arpita Bhattacharyya
No abstract text is available yet for this article.
February 23, 2017: Journal of Pediatric Hematology/oncology
Lei Chai, Da Chen, Xiao-Bing Tang, Yun Ge, Ying Chen, Jun Li
Real-time monitoring and amendment of patient position is important for the radiotherapy. However, using electronic portal imaging device (EPID) and cone beam computer tomography (CBCT) in the clinical practice generate different degrees of delay, so that they cannot achieve the purpose of real-time application. Meanwhile, a few products come with the function of the real-time monitoring and amendment, such as CyberKnife, which is too expensive for the common people. The objective of this study is to develop and test a novel independent system to monitor treatment center and amend the position of patient, which is applicable to most accelerators, based on binocular location...
February 21, 2017: Journal of X-ray Science and Technology
Kaitlin Christopherson, Christopher G Morris, Jessica M Kirwan, Robert J Amdur, Peter T Dziegielewski, Brian J Boyce, William M Mendenhall
OBJECTIVES/HYPOTHESIS: To evaluate the long-term disease control, survival, and complications after definitive radiotherapy (RT) alone or combined with adjuvant chemotherapy with or without planned neck dissection for base of tongue squamous cell carcinoma (SCC). STUDY DESIGN: We retrospectively reviewed the medical records of 467 patients treated at the University of Florida with definitive RT alone or combined with adjuvant chemotherapy between 1964 and 2011 for base of tongue SCC...
February 24, 2017: Laryngoscope
Jung Hun Oh, Sarah Kerns, Harry Ostrer, Simon N Powell, Barry Rosenstein, Joseph O Deasy
The biological cause of clinically observed variability of normal tissue damage following radiotherapy is poorly understood. We hypothesized that machine/statistical learning methods using single nucleotide polymorphism (SNP)-based genome-wide association studies (GWAS) would identify groups of patients of differing complication risk, and furthermore could be used to identify key biological sources of variability. We developed a novel learning algorithm, called pre-conditioned random forest regression (PRFR), to construct polygenic risk models using hundreds of SNPs, thereby capturing genomic features that confer small differential risk...
February 24, 2017: Scientific Reports
A Huertas, S Oldrini, J-P Nesseler, F Courrech, P Rétif, C Charra-Brunaud, D Peiffert
The treatment of cervical cancers according to FIGO staging is well defined. For FIGO stage IB2 or more, chemoradiotherapy followed by uterovaginal brachytherapy boost is the standard treatment. Surgery is the preferred choice for less advanced tumors. However, most French institutions propose preoperative brachytherapy followed by hysterectomy with pelvic lymphadenectomy for FIGO stage IB1 tumors over 2cm. Brachytherapy is also used for the boost after adjuvant pelvic external beam radiotherapy. Tridimensional dosimetry with optimization allows better treatment planning, delivering high doses to target volumes with limited irradiation to the organs at risk...
February 20, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
V Machado, S Troncoso, L Mejías, M Á Idoate, M San-Julián
OBJECTIVE: To evaluate the clinical, radiological and histological factors that can predict local recurrence of fibromatosis. METHODS: A retrospective study was conducted on 51 patients diagnosed with fibromatosis in this hospital from 1983 to 2014. The mean follow-up was 83 months. A study was made of the clinical parameters, location, depth, size, surgical margins, and proliferation index (Ki-67). An evaluation was also made of the risk of recurrence depending on the adjuvant treatment and the relationship between treatment and patient functionality...
February 20, 2017: Revista Española de Cirugía Ortopédica y Traumatología
Daniel E Spratt, Jae Y Lee, Robert T Dess, Vrinda Narayana, Cheryl Evans, Adam Liss, Raymond Winfield, Matthew J Schipper, Theodore S Lawrence, Patrick W McLaughlin
BACKGROUND: Erectile dysfunction remains the most common side effect from radical treatment of localized prostate cancer. We hypothesized that the use of vessel-sparing radiotherapy, analogous to the functional anatomy approach of nerve-sparing radical prostatectomy (RP), would improve erectile function preservation while maintaining tumor control for men with localized prostate cancer. OBJECTIVE: To determine erectile function rates after vessel-sparing radiotherapy...
February 20, 2017: European Urology
Frances Duane, Marianne C Aznar, Freddie Bartlett, David J Cutter, Sarah C Darby, Reshma Jagsi, Ebbe L Lorenzen, Orla McArdle, Paul McGale, Saul Myerson, Kazem Rahimi, Sindu Vivekanandan, Samantha Warren, Carolyn W Taylor
BACKGROUND AND PURPOSE: The heart is a complex anatomical organ and contouring the cardiac substructures is challenging. This study presents a reproducible method for contouring left ventricular and coronary arterial segments on radiotherapy CT-planning scans. MATERIAL AND METHODS: Segments were defined from cardiology models and agreed by two cardiologists. Reference atlas contours were delineated and written guidelines prepared. Six radiation oncologists tested the atlas...
February 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Andrea Ferrari, Chiara Magni, Luca Bergamaschi, Giovanni Cecchetto, Rita Alaggio, Giuseppe Maria Milano, Patrizia Bertolini, Eleonora Basso, Carla Manzitti, Martina Di Martino, Nauga Giurici, Fraia Melchionda, Valerio Cecinati, Stefano Chiaravalli, Maria Carmen Affinita, Angela Scagnellato, Michela Casanova, Gianni Bisogno
BACKGROUND: Pediatric nonrhabdomyosarcoma soft tissue sarcomas (NRSTS) may rarely occur in visceral tissues, and little is known about their clinical history. The present study retrospectively analyzed a group of patients prospectively registered in Italian pediatric protocols conducted between 1979 and 2004. METHODS: Inclusion criteria for the study were as follows: a pathological diagnosis of "adult-type NRSTS," arising at visceral sites (lung-pleurae, liver, kidney, and mesentery-bowel); age under 18 years; no previous treatment except for primary surgery; available clinical data; and written consent...
February 24, 2017: Pediatric Blood & Cancer
Chan Kim, Kwai Han Yoo, Min Hwan Kim, Hong Jae Chon, Soon Il Lee, Hyo Jin Lee, Sujin Koh, Ha Yeon Lee, Hye Ran Lee, Kyung Sik Kim, Young Deuk Choi, Sun Young Rha, Su Jin Lee, Hyo Song Kim
Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence...
March 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Kathrin Milbury, April Kavanagh, Zhiqiang Meng, Zhen Chen, Kavita D Chandwani, Kay Garcia, George H Perkins, Jennifer McQuade, Nelamangala V Raghuram, Raghuram Nagarathna, Zhongxing Liao, Hongasandra Ramarao Nagendra, Jiayi Chen, Xiaoma Guo, Luming Liu, Banu Arun, Lorenzo Cohen
PURPOSE: Research in the area of cultural response pattern on questionnaires in the oncological setting and direct cross-cultural comparisons are lacking. This study examined response pattern in the reporting of depressive symptoms in Chinese and US women with breast cancer. We hypothesized that Chinese women are less likely to endorse positive affect items compared to their US counterparts. Additionally, we explored cultural differences in the association between positive affect and QOL...
February 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Volker Rudat, Alaa Nour, Mohamed Hammoud, Salam Abou Ghaida
BACKGROUND: The aim of the study was to identify factors significantly associated with the occurrence of unintended treatment interruptions in adjuvant breast cancer radiotherapy. PATIENTS AND METHODS: Patients treated with postoperative radiotherapy of the breast or chest wall between March 2014 and August 2016 were evaluated. The radiotherapy regimens and techniques applied were either conventional fractionation (CF; 28 daily fractions of 1.8 Gy or 25 fractions of 2...
February 23, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Qingxi Yue, Guogang Gao, Gangyong Zou, Haiqing Yu, Xi Zheng
Pancreatic cancer is a type of common malignant tumors with high occurrence in the world. Most patients presented in clinic had pancreatic cancer at advanced stages. Furthermore, chemotherapy or radiotherapy had very limited success in treating pancreatic cancer. Complementary and alternative medicines, such as natural products/herbal medicines, represent exciting adjunctive therapies. In this review, we summarize the recent advances of using natural products/herbal medicines, such as Chinese herbal medicine, in combination with conventional chemotherapeutic agents to treat pancreatic cancer in preclinical and clinical trials...
2017: BioMed Research International
Sandra Rutzner, Rainer Fietkau, Thomas Ganslandt, Hans-Ulrich Prokosch, Dorota Lubgan
INTRODUCTION: The purpose of this study is to verify the possible benefit of a clinical data warehouse (DWH) for retrospective analysis in the field of radiation oncology. MATERIAL AND METHODS: We manually and electronically (using DWH) evaluated demographic, radiotherapy, and outcome data from 251 meningioma patients, who were irradiated from January 2002 to January 2015 at the Department of Radiation Oncology of the Erlangen University Hospital. Furthermore, we linked the Oncology Information System (OIS) MOSAIQ(®) to the DWH in order to gain access to irradiation data...
2017: Frontiers in Oncology
Jeroen Meulemans, Christophe Vanclooster, Tom Vauterin, Emmanuel D'heygere, Sandra Nuyts, Paul M Clement, Robert Hermans, Pierre Delaere, Vincent Vander Poorten
INTRODUCTION/AIM: We analyzed the functional and oncologic outcomes of primary and salvage transoral robotic surgery (TORS) procedures, performed in three Belgian institutions with a similar philosophy. PATIENTS AND METHODS: A total of 86 patients who underwent TORS between 24-12-2009 and 25-09-2015 were retrospectively reviewed. Descriptive statistics, overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS; Kaplan-Meier), and the variation of these outcomes according to whether patients had primary or salvage TORS were evaluated (univariate log-rank analysis)...
2017: Frontiers in Oncology
Kuntal Biswas, Sukumar Sarkar, Kangping Du, David L Brautigan, Tarek Abbas, James M Larner
: Lung cancer resists radiation therapy, making it one of the deadliest forms of cancer. Here we show that human lung cancer cell lines can be rendered sensitive to ionizing radiation (IR) by RNAi knockdown of Cterminus of Hsc70-interacting protein (CHIP/STUB1), a U-box-type E3 ubiquitin ligase that targets a number of stress-induced proteins. Mechanistically ubiquitin-dependent degradation of the cyclin-dependent kinase (CDK) inhibitor p21 protein is reduced by CHIP knockdown, leading to enhanced senescence of cells in response to exposure to IR...
February 23, 2017: Molecular Cancer Research: MCR
Mark Martin Jensen, Wanjian Jia, Kyle J Isaacson, Austin Schults, Joseph Cappello, Glenn D Prestwich, Siam Oottamasathien, Hamidreza Ghandehari
Radiation-induced proctitis (RIP) is the most common clinical adverse effect for patients receiving radiotherapy as part of the standard course of treatment for ovarian, prostate, colon, and bladder cancers. RIP limits radiation dosage, interrupts treatment, and lowers patients' quality of life. A prophylactic treatment that protects the gastrointestinal tract from deleterious effects of radiotherapy will significantly improve patient quality of life and may allow for higher and more regular doses of radiation therapy...
February 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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