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https://www.readbyqxmd.com/read/29457751/intra-and-inter-fraction-uncertainties-during-igrt-for-wilms-tumor
#1
Filipa Guerreiro, Enrica Seravalli, Geert O Janssens, Cees P van de Ven, Marry M van den Heuvel-Eibrink, Bas W Raaymakers
BACKGROUND AND PURPOSE: To assess intra- and inter-fraction motion uncertainties, due to displacements of the tumor bed (TB) and organs at risk (OAR), as well as intra- and inter-fraction patient set-up uncertainties, due to positioning variations, during image-guided radiation therapy (IGRT) in children with Wilms' tumor. MATERIAL AND METHODS: Four-dimensional computed tomography (4D-CT) and daily pre- and post-treatment cone-beam CT (CBCT)-scans of 15 patients (average 4, range 1-8 years) undergoing flank irradiation after nephrectomy were analyzed...
February 19, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29457225/aperture-generation-based-on-threshold-segmentation-for-intensity-modulated-radiotherapy-treatment-planning
#2
Jie Yang, Zhiguo Gui, Liyuan Zhang, Pengcheng Zhang
PURPOSE: To reduce computation and decrease planning time with little or no loss in plan quality compared to the column-generation-based (cg) method, a simple method of aperture generation based on threshold segmentation (agts) is proposed. METHODS: The proposed agts strategy consists of two steps. First, a fuzzy controller is used for noise cancellation; then, new apertures are added using the threshold segmentation algorithm. We tested the proposed method on seven prostate tumor cases using the computational environment for radiotherapy research algorithms for the dose calculations and compared the results with those obtained by generating the plan aperture using the cg method...
February 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29456738/recurrence-of-adenoid-cystic-carcinoma-of-the-trachea-treated-with-radical-radiotherapy-a-case-report
#3
Konrad Pawlewicz, Zbigniew Szutkowski, Andrzej Kawecki
Adenoid cystic carcinoma (ACC) of the trachea is a relatively rare tumor among thoracic diseases. The present study reports the case of a 23-year-old woman with ACC of the trachea who underwent surgical resection of the tumor in The National Institute of Tuberculosis and Lung Diseases (Warsaw, Poland). Histopathological examination revealed that the tumor was not completely resected (R2 resection) and strict observation of the patient was therefore prescribed. After ~9 years of follow-up, clinical and histopathological tumor progression was confirmed and the patient was referred to the Centre of Oncology in Warsaw...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456736/-brucea-javanica-seed-oil-enhances-the-radiosensitivity-of-esophageal-cancer-by-inhibiting-hypoxia-inducible-factor-1%C3%AE-in-vitro-and-in-vivo
#4
Peng Pan, Bai-Xia Yang, Xiao-Lin Ge
Brucea javanica oil emulsion (BJOE) has been used clinically to treat esophageal cancer combined with radiotherapy for numerous years in China. However, the detailed mechanism remains unclear. Thus, the effects of BJOE on the radiosensitivity of esophageal squamous cell carcinoma (ESCC) were evaluated in vitro and in vivo . The growth inhibitory effects of different BJOE concentrations were determined through an MTT assay. Radiosensitivity was evaluated through focal formation measurements and clone formation assays...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456704/optimal-method-of-gold-nanoparticle-administration-in-melanoma-bearing-mice
#5
Tetsuya Komatsu, Katsumasa Nakamura, Yasuhiro Okumura, Kenta Konishi
The present study assessed different methods of administering gold nanoparticles (GNPs) using different formulations to determine which of the methods achieved optimal radiosensitization. Cells from the B16F10 mouse melanoma cell line were implanted in the femoral area of mice, assigned to one of the eight following groups: i) Control; ii) intravenous (IV) injection of polyethylene glycol (PEG)-binding GNPs (Peg-GNPs) alone; iii) direct intratumoral (IT) injection of Peg-GNPs alone; iv) radiotherapy (RT)-alone; v) Peg-GNP IV + RT; vi) Peg-GNP IT + RT; vii) naked GNP (N-GNPs) IV + RT; and viii) N-GNP IT + RT...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456472/electron-beam-intraoperative-radiotherapy-eliot-in-pregnant-women-with-breast-cancer-from-in-vivo-dosimetry-to-clinical-practice
#6
Maria Leonardi, Agnese Cecconi, Rosa Luraschi, Elena Rondi, Federica Cattani, Roberta Lazzari, Anna Morra, Santos Soto, Vanna Zanagnolo, Viviana Galimberti, Oreste Gentilini, Fedro Peccatori, Barbara Jereczek-Fossa, Roberto Orecchia
Background: The aim of this study was to confirm our preliminary results with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman. Patients and Methods: Following our previous experience, 5 non-pregnant patients receiving ELIOT to the tumor bed after breast-conserving surgery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29455924/gec-estro-acrop-recommendations-in-skin-brachytherapy
#7
Jose L Guinot, Agata Rembielak, Jose Perez-Calatayud, Silvia Rodríguez-Villalba, Janusz Skowronek, Luca Tagliaferri, Benjamin Guix, Victor Gonzalez-Perez, Vincenzo Valentini, György Kovacs
PURPOSE: The aim of this publication is to compile available literature data and expert experience regarding skin brachytherapy (BT) in order to produce general recommendations on behalf of the GEC-ESTRO Group. METHODS: We have done an exhaustive review of published articles to look for general recommendations. RESULTS: Randomized controlled trials, systemic reviews and meta-analysis are lacking in literature and there is wide variety of prescription techniques successfully used across the radiotherapy centers...
February 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29455898/does-emotional-talk-vary-with-fears-of-cancer-recurrence-trajectory-a-content-analysis-of-interactions-between-women-with-breast-cancer-and-their-therapeutic-radiographers
#8
L Barracliffe, Y Yang, J Cameron, C Bedi, G Humphris
Fears of cancer recurrence (FCR) in patients with breast cancer are hypothesised to develop over the period from diagnosis, through treatment and thereafter. A crucial point may be the contact that patients have with their therapeutic radiographer in review appointments. The study aimed to (1) describe and categorise the content of the identified emotional talk, and (2) consider the evidence for an association of content with FCR trajectory. METHODS: A concurrent mixed methods approach was applied as part of a larger investigation (FORECAST) of breast cancer patients (n=87)...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29455369/intradural-spinal-tumors-in-adults-update-on-management-and-outcome
#9
REVIEW
Malte Ottenhausen, Georgios Ntoulias, Imithri Bodhinayake, Finn-Hannes Ruppert, Stefan Schreiber, Annette Förschler, John A Boockvar, Andreas Jödicke
Among spinal tumors that occur intradurally, meningiomas, nerve sheath tumors, ependymomas, and astrocytomas are the most common. While a spinal MRI is the state of the art to diagnose intradural spinal tumors, in some cases CT scans, angiography, CSF analyses, and neurophysiological examination can be valuable. The management of these lesions depends not only on the histopathological diagnosis but also on the clinical presentation and the anatomical location, allowing either radical resection as with most extramedullary lesions or less invasive strategies as with intramedullary lesions...
February 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29455079/automatic-detection-and-segmentation-of-brain-metastases-on-multimodal-mr-images-with-a-deep-convolutional-neural-network
#10
Odelin Charron, Alex Lallement, Delphine Jarnet, Vincent Noblet, Jean-Baptiste Clavier, Philippe Meyer
Stereotactic treatments are today the reference techniques for the irradiation of brain metastases in radiotherapy. The dose per fraction is very high, and delivered in small volumes (diameter <1 cm). As part of these treatments, effective detection and precise segmentation of lesions are imperative. Many methods based on deep-learning approaches have been developed for the automatic segmentation of gliomas, but very little for that of brain metastases. We adapted an existing 3D convolutional neural network (DeepMedic) to detect and segment brain metastases on MRI...
February 9, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29454959/exophytic-cerebral-hemispheric-low-grade-glioma-an-unusual-growth-pattern-of-a-common-central-nervous-system-tumour
#11
Suyash Singh, Kuntal Kanti Das, Sushila Jaiswal, Raj Kumar
BACKGROUND: Exophytic growth (EG), where in the tumor mass grows beyond the neuraxial boundary formed by pia mater, remains a rare pattern of glioma growth. It has been described in gliomas at several locations like the brainstem, cerebellum, suprasellar area, spinal cord and the insula. However, EG in hemispheric grade 2 astrocytomas, particularly affecting the convexity subarachnoid space, as against the more spacious basal subarachnoid space, is exceedingly rare. To the best of our knowledge, there is only one such case reported in the English literature...
February 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454863/potentially-functional-variants-of-atg16l2-predict-radiation-pneumonitis-and-outcomes-in-patients-with-non-small-cell-lung-cancer-after-definitive-radiotherapy
#12
Juyi Wen, Hongliang Liu, Lili Wang, Xiaomeng Wang, Ning Gu, Zhensheng Liu, Ting Xu, Daniel R Gomez, Ritsuko Komaki, Zhongxing Liao, Qingyi Wei
INTRODUCTION: Autophagy not only plays an important role in the progression of cancer but also is involved in tissue inflammatory response. However, few published studies have investigated associations between functional genetic variants of autophagy-related genes and radiation pneumonitis (RP) as well as clinical outcomes in patients with non-small cell lung cancer (NSCLC) after definitive radiotherapy. METHODS: We genotyped nine potentially functional single nucleotide polymorphisms (SNPs) in four autophagy-related genes (ATG2B, ATG10, ATG12 and ATG16L2) in 393 North American NSCLC patients treated by definitive radiotherapy and assessed their associations with RP, local recurrence-free survival (LRFS), progression-free survival (PFS) and overall survival (OS) in multivariable Cox proportional hazards regression analyses...
February 15, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29454737/adjuvant-radiotherapy-for-positive-lymph-nodes-of-oesophageal-squamous-cell-carcinoma-can-it-earn-promising-benefits-at-long-term-follow-up
#13
Y Ren, J Ye, W Xiong, J Zuo, Y He, M Tan, Y Yuan
PURPOSE: The value of adjuvant radiotherapy for patients with positive lymph nodes after curative resection of oesophageal squamous cell carcinoma is controversial. This study aims to investigate its long-term benefits in a specific cohort. PATIENTS AND METHODS: The charts between 1990 and 2003 from patients with positive lymph nodes were retrospectively reviewed. Those subjects were divided into adjuvant radiotherapy and surgery alone groups, with two subgroups defined by radiation dose (cutoff value: 50Gy)...
February 14, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29454505/current-management-of-intracranial-germ-cell-tumours
#14
A Bowzyk Al-Naeeb, M Murray, G Horan, F Harris, R-D Kortmann, J Nicholson, T Ajithkumar
Intracranial germ cell tumours (icGCTs) are uncommon tumours occurring in children and young adults. They are usually segregated into germinomas and non-germinomatous tumours (NGGCTs) in most classifications. Germinomas are highly curable tumours with multimodality treatment, but NGGCTs are associated with poorer survival outcomes. There are some differences in the approach to the management of icGCTs globally. Current research generally focuses on reducing treatment intensity, particularly the dose and volume of radiotherapy, in order to minimise the risks of late sequelae while maintaining high cure rates in icGCTs...
February 14, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29454338/-factors-associated-with-non-small-cell-lung-cancer-treatment-costs-in-a-brazilian-public-hospital
#15
Carla de Barros Reis, Renata Erthal Knust, Claudia Cristina de Aguiar Pereira, Margareth Crisóstomo Portela
BACKGROUND: The present study estimated the cost of advanced non-small cell lung cancer care for a cohort of 251 patients enrolled in a Brazilian public hospital and identified factors associated with the cost of treating the disease, considering sociodemographic, clinical and behavioral characteristics of patients, service utilization patterns and survival time. METHODS: Estimates were obtained from the survey of direct medical cost per patient from the hospital's perspective...
February 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29454311/radiotherapy-related-skin-toxicity-rarest-01-mepitel%C3%A2-film-versus-standard-care-in-patients-with-locally-advanced-head-and-neck-cancer
#16
Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl, Dirk Rades
BACKGROUND: The aim of the present trial is to investigate a new option of skin protection in order to reduce the rate of grade ≥ 2 skin toxicity in patients receiving radiotherapy alone or radiochemotherapy for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). METHODS / DESIGN: This is a randomized, active-controlled, parallel-group multi-center trial that compares the following treatments of radiation dermatitis in patients with head-and-neck cancer: Mepitel® Film (Arm A) vs...
February 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29454155/immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer-nsclc-approaches-on-special-subgroups-and-unresolved-burning-questions
#17
REVIEW
J Remon, N Vilariño, N Reguart
Immune checkpoint inhibitors (ICIs) have been incorporated in the treatment strategy of advanced non-small cell lung cancer (NSCLC). Beyond the already approved indications in first- and second-line setting of advanced NSCLC, new data has recently emerged demonstrating its efficacy in locally advanced disease as maintenance after chemo-radiotherapy and currently several trials are also exploring its efficacy in earlier stages of the disease to evaluate whether these results could be extrapolated to the adjuvant setting...
February 8, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29454123/cardiac-metastasis-from-clivus-chordoma-a-case-report
#18
Jun Won Kim, Chang-Ki Hong, Yoon Jin Cha, Se Hoon Kim, Chang-Ok Suh, Kyu-Sung Lee
BACKGROUND: Chordomas are rare tumors showing locally aggressive nature and high rates of local recurrences. Distant metastases are infrequently reported and cardiac metastases are extremely rare. CASE DESCRIPTION: A 32-year-old woman had been diagnosed with a large chordoma involving the clivus. She received a total removal of the tumor and adjuvant intensity-modulated radiotherapy. Four and a half years after the surgery, she presented with multifocal lesions in the ventricles and the right atrium, although an open thoracotomy revealed chronic inflammation...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453893/cbct-guided-evolutive-library-for-cervical-adaptive-imrt
#19
Bastien Rigaud, Antoine Simon, Maxime Gobeli, Caroline Lafond, Julie Leseur, Anais Barateau, Nicolas Jaksic, Joël Castelli, Danièle Williaume, Pascal Haigron, Renaud De Crevoisier
PURPOSE: In the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone-beam computed tomography (CBCT)-guided "Evolutive library" and evaluated it against four other known radiotherapy (RT) strategies. MATERIAL AND METHODS: For 20 patients who underwent intensity-modulated radiation therapy (IMRT) for LACC, three planning CTs (with empty [EB], intermediate [IB], and full [FB] bladder volumes), a CT scan at 20 Gy and bi-weekly CBCTs for 5 weeks were performed...
February 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29453830/eosinophilic-polymorphic-and-pruritic-eruption-associated-with-radiotherapy-in-a-patient-with-primary-nodal-merkel-cell-carcinoma
#20
Wedad Abdelrahman, Lin Shum, Damian McManus, Maureen Y Walsh, Olivia Dolan
No abstract text is available yet for this article.
February 16, 2018: International Journal of Dermatology
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