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https://www.readbyqxmd.com/read/29141849/polycystic-ovary-syndrome-oligomenorrhea-and-risk-of-ovarian-cancer-histotypes-evidence-from-the-ovarian-cancer-association-consortium
#1
Holly R Harris, Ana Babic, Penelope M Webb, Christina M Nagle, Susan J Jordan, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Marc T Goodman, Francesmary Modugno, Roberta B Ness, Kirsten B Moysich, Susanne K Kjaer, Estrid Høgdall, Allan Jensen, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Elisa V Bandera, Nicolas Wentzensen, Joanne Kotsopoulos, Steven A Narod, Catherine M Phelan, John R McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Celeste Leigh Pearce, Anna H Wu, Kathryn L Terry
BACKGROUND: Polycystic ovary syndrome (PCOS), and one if its distinguishing characteristics, oligomenorrhea, have both been associated with ovarian cancer risk in some but not all studies. However, these associations have been rarely been examined by ovarian cancer histotypes which may explain the lack of clear associations reported in previous studies. METHODS: We analyzed data from 14 case-control studies including 16,594 women with invasive ovarian cancer (n=13,719) or borderline ovarian disease (n=2,875) and 17,718 controls...
November 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29137401/hormone-receptors-expression-in-ovarian-cancer-taking-into-account-menopausal-status-a-retrospective-study-in-chinese-population
#2
Fang Shen, Xuyin Zhang, Yiqun Zhang, Jingxin Ding, Qi Chen
Ovarian cancer is a major gynaecological cancer with different subtypes and studies have suggested that estrogen receptor (ER) or progesterone receptor (PR) positivity are associated with better clinical outcomes. Furthermore, the clinical outcomes of ovarian cancer are better in Asian compared to Caucasian. To date, studies investigating the ER or PR positivity in all subtypes of ovarian cancer, including borderline epithelial, are limited. In this retrospective study we investigated ER and PR positivity in Chinese women with malignant epithelial ovarian cancer (n=577), sex cord-stromal tumor (n=26) and borderline epithelial ovarian cancer (n=98) taking into account menopausal status...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137100/ultrasonic-and-pathological-characteristics-of-ovarian-mucinous-cystic-tumors-with-malignant-mural-nodules-two-cases-report
#3
Yan Zhang, Zheng Yuan, Kai Sun, Peifeng Li
RATIONALE: Sarcomatous or anaplastic carcinoma mural nodules presenting in ovarian mucinous cystic tumors are very rare. Here, we reported the ultrasonic and pathological features of 2 such cases. PATIENT CONCERNS: A 60-year-old woman presented with a complaint of lower abdominal pain. Physical examination revealed a hard, palpable mass in her right lower abdomen with mild tenderness. In addition, a 48-year-old woman presented with left abdominal pain and abdominal fullness...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29119698/differences-in-the-ultrasound-features-of-papillations-in-unilocular-solid-adnexal-cysts-a-retrospective-international-multicenter-study
#4
Chiara Landolfo, Lil Valentin, Dorella Franchi, Caroline Van Holsbeke, Robert Fruscio, Wouter Froyman, Povilas Sladkevicius, Jeroen Kaijser, Lieveke Ameye, Tom Bourne, Luca Savelli, An Coosemans, Antonia Testa, Dirk Timmerman
OBJECTIVES: The aim is to determine if there are any ultrasound features of papillations or of the cyst wall that can discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. METHODS: Patients with an adnexal lesion described at ultrasonography as unilocular-solid with papillations but no other solid components were identified from the International Ovarian Tumor Analysis (IOTA) database derived from seven ultrasound centers...
November 8, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29119232/histopathological-markers-of-treatment-response-and-recurrence-risk-in-ovarian-cancers-and-borderline-tumors
#5
REVIEW
S Avril
Histopathology plays an important role in defining response to treatment for different tumor types. Histopathologic response criteria are currently used as reference standard in various types of cancer, including breast cancer, gastroesophageal cancer, and bone tumors. Since there were no generally accepted response criteria established for ovarian cancer, a systematic analysis of various features of tumor regression was performed. Patient survival served as the reference standard to validate the histopathologic features of tumor regression...
November 8, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29113327/the-prevalence-of-malignant-and-borderline-ovarian-cancer-in-pre-and-post-menopausal-chinese-women
#6
Fang Shen, Shouzhen Chen, Yifei Gao, Xujing Dai, Qi Chen
The incidence of ovarian cancer depends on the ethnicity and geographical area. Menopausal status is a well-known risk factor for ovarian cancer and most cases occur after menopause in Caucasians. However, it is less clear how the status of menopause or age at diagnosis is associated with ovarian cancer including its subtypes in Chinese women. Data on 1,283 women with primary malignant or borderline ovarian cancer including age at diagnosis, age at menopause and histology from the largest women's hospital in China was analysed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112653/long-term-results-for-expectant-management-of-ultrasonographically-diagnosed-benign-ovarian-teratomas
#7
M Angela Pascual, Betlem Graupera, Cristina Pedrero, Ignacio Rodriguez, Silvia Ajossa, Stefano Guerriero, Juan Luis Alcázar
OBJECTIVE: To assess the natural history of ultrasonographically diagnosed benign ovarian teratomas in asymptomatic women. METHODS: We conducted a retrospective observational cohort study of 408 women (mean age 36.6 years, range 14-81 years) diagnosed as having an ovarian teratoma by transvaginal ultrasonography (except eight who only had a transabdominal study done) between January 2003 and December 2013 at a single tertiary care institution. Six hundred thirteen women were diagnosed with ovarian teratoma of whom 205 were promptly treated surgically, leaving 408 patients followed conservatively with follow-up scans at 3 and 6 months from diagnosis and then yearly...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29106744/germ-cell-tumor-growth-patterns-originating-from-clear-cell-carcinomas-of-the-ovary-and-endometrium-a-comparative-immunohistochemical-study-favouring-their-origin-from-somatic-stem-cells
#8
F F Nogales, J Prat, M Schuldt, N Cruz-Viruel, B Kau, E D'Angelo, X Matias-Guiu, A Vidal, W G McCluggage, J W Oosterhuis
AIMS: To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical and demonstrate a putative stem cell population. METHODS AND RESULTS: The clear cell tumours included 11 clear cell carcinomas (CCC) and 1 borderline clear cell tumour, while the GCT always included glandular yolk sac tumour (YST). In 4 cases, there were also foci of teratoma with immature neuroepithelial and endodermal tissues, and undifferentiated areas showing true embryoids...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29100380/circulating-tumor-cells-in-the-differential-diagnosis-of-adnexal-masses
#9
Dong Hoon Suh, Miseon Kim, Jin Young Choi, Jiyoon Bu, Yoon-Tae Kang, Byung Su Kwon, Banghyun Lee, Kidong Kim, Jae Hong No, Yong-Beom Kim, Young-Ho Cho
The aim of this study was to evaluate circulating tumor cell (CTC) detection in the differential diagnosis of adnexal masses. A total of 87 preoperative women with an indeterminate adnexal mass were prospectively enrolled. Preoperative diagnostic modalities including CTC detection, risk of ovarian malignancy algorithm, risk of malignancy index, and computed tomography or magnetic resonance imaging were compared. Forty-three (49.4%) benign tumors, 13 (14.9%) borderline malignant masses, and 31 (35.7%) cancers were pathologically confirmed...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29079174/mir-223-potentially-targets-swi-snf-complex-protein-smarcd1-in-atypical-proliferative-serous-tumor-and-high-grade-ovarian-serous-carcinoma
#10
Florence A Arts, Lisa Keogh, Paul Smyth, Sharon O'Toole, Robert Ta, Noreen Gleeson, John J O'Leary, Richard Flavin, Orla Sheils
Ovarian cancer is the fifth most common cancer in women worldwide and has the highest mortality amongst gynecological cancers. miRNAs are a class of non-coding RNAs, approximately 22 nt long, that negatively regulate gene expression and to have roles in cell growth, differentiation, metabolism, apoptosis and tumorigenesis. Dysregulated miRNA-223 expression has been implicated in a wide range of cancer subtypes. SMARCD1 is an integral protein component of the SWI/SNF complex which remodels chromatin, and which has important roles in transcriptional control, DNA replication, recombination and repair...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29078734/ovarian-cancer-stem-cells-unravelling-a-germline-connection
#11
Seema Chandrakant Parte, Andrei S Smolenkov, Surinder K Batra, Mariusz Z Ratajczak, Sham Sunder Kakar
Ovarian cancer is most lethal among gynaecological cancers with often fatal consequences due to lack of effective bio-markers and relapse which propels ovarian cancer research into unique directions to establish solid targeted therapeutics. 'Ovarian stem cells' expressing germline, pluripotent markers serve as novel paradigm with potential to address infertility, menopause and probably influence tumor initiation. Cancer stem cells (CSCs) pose vital role in tumor recurrence and hence it is extremely important to study them with respect to ovarian stem cells across various cancer stages and normal ovaries...
October 27, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29039491/non-canonical-hedgehog-signaling-activation-in-ovarian-borderline-tumors-and-ovarian-carcinomas
#12
Petar Ozretić, Diana Trnski, Vesna Musani, Ivana Maurac, Držislav Kalafatić, Slavko Orešković, Sonja Levanat, Maja Sabol
Hedgehog signaling pathway has been implicated in the pathology of ovarian cancer, and Survivin (BIRC5) has been suggested as a novel target of this pathway. Herein we investigated the role of Hedgehog signaling pathway and Survivin in ovarian carcinoma and borderline tumor samples. We aimed to determine possible ways of pathway modulation on primary ovarian cancer cells and an established cell line. RNA was extracted from fresh tumors and control tissues and gene expression was examined using qRT-PCR. Pathway activity in cell lines was examined after treatment with cyclopamine, SHH protein, GANT-61 or lithium chloride using qRT-PCR, western blot and confocal microscopy...
October 12, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29034605/useful-aspects-of-diagnosis-of-imprint-cytology-in-intraoperative-consultation-of-ovarian-tumors-comparison-between-imprint-cytology-and-frozen-sections
#13
Shiho Azami, Yuuji Aoki, Mizuki Iino, Asumi Sakaguchi, Kanako Ogura, Daiki Ogishima, Toshiharu Matsumoto
BACKGROUND: In the intraoperative consultation of ovarian tumors, the histological diagnosis of frozen sections (FS) of large tumors is frequently difficult because of the limited number of tumor samples. The application of imprint cytology (IC), in which samples are obtained from wide areas of the tumors, is useful for intraoperative consultation. However, the useful aspects of IC have not been clearly defined. The present study is a detailed comparison of IC and FS that clearly defines the useful aspects of IC...
October 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29027536/kras-mutation-of-extraovarian-implants-of-serous-borderline-tumor-prognostic-indicator-for-adverse-clinical-outcome
#14
Tao Zuo, Serena Wong, Natalia Buza, Pei Hui
In contrast to non-invasive extraovarian implants, invasive implants of ovarian serous borderline tumor/atypical proliferative serous tumor are associated with adverse outcome and have been reclassified as low-grade serous carcinoma. Mutations of KRAS and/or BRAF have been reported in up to 50% of serous borderline tumor/atypical proliferative serous tumor. We investigated KRAS and BRAF mutation frequencies in the two types of implants of serous borderline tumor/atypical proliferative serous tumor in correlation with clinical outcome...
October 13, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29022892/the-lncrna-hulc-functions-as-an-oncogene-by-targeting-atg7-and-itgb1-in-epithelial-ovarian-carcinoma
#15
Shuo Chen, Dan-Dan Wu, Xiu-Bo Sang, Li-Li Wang, Zhi-Hong Zong, Kai-Xuan Sun, Bo-Liang Liu, Yang Zhao
Highly upregulated in liver cancer (HULC) is a long noncoding RNA (lncRNA), which has recently been identified as a key regulator in the progression of hepatocellular carcinoma, gliomas and gastric cancer. However, its role in epithelial ovarian carcinoma (EOC) remains unknown. In this study, HULC expression was examined in EOC, borderline and benign ovarian tumors, and normal ovarian tissues by RT-PCR. Ovarian cancer cell phenotypes, as well as autophagy-associated proteins were examined after HULC overexpression or downregulation by plasmid or small interfering RNA (siRNA) transfection, respectively...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28993546/differentiation-of-seromucinous-borderline-tumor-from-serous-borderline-tumor-on-mr-imaging
#16
Yasuhisa Kurata, Aki Kido, Yusaku Moribata, Kyoko Kameyama, Sachiko Minamiguchi, Ikuo Konishi, Kaori Togashi
PURPOSE: Seromucinous borderline tumor (SMBT) is a newly categorized ovarian tumor in the 2014 revised World Health Organization (WHO) classification. SMBT is similar to serous borderline tumor (SBT) on magnetic resonance imaging (MRI) reflecting their pathological findings. This study was conducted to demonstrate the usefulness of MRI findings and quantitative values for differentiating SMBT from SBT. METHODS: This retrospective study examined 23 lesions (20 patients) from SMBT and 26 lesions (22 patients) from SBT...
October 6, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28992761/kras-mutation-testing-in-borderline-ovarian-tumors-and-low-grade-ovarian-carcinomas-with-a-rapid-fully-integrated-molecular-diagnostic-system
#17
Pawel Sadlecki, Paulina Antosik, Dariusz Grzanka, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Epithelial ovarian neoplasms are a heterogeneous group of tumors, including various malignancies with distinct clinicopathologic and molecular features. Mutations in BRAF and KRAS genes are the most frequent genetic aberrations found in low-grade serous ovarian carcinomas and serous and mucinous borderline tumors. Implementation of targeted therapeutic strategies requires access to highly specific and highly sensitive diagnostic tests for rapid determination of mutation status. One candidate for such test is fully integrated, real-time polymerase chain reaction-based Idylla™ system for quick and simple detection of KRAS mutations in formaldehyde fixed-paraffin embedded tumor samples...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28984773/ovarian-torsion-of-mixed-epithelial-tumor-misdiagnosed-as-a-malignancy-in-postmenopausal-woman-a-case-report
#18
Hyeji Jeon, Aeli Ryu, Hui-Gyeong Seo, Si-Hyong Jang
RATIONALE: Adnexal torsion is 1 of the most common emergency gynecological disease. It is more often diagnosed in reproductive age, but rarely in postmenopausal women. The clinical symptoms of adnexal torsion are nonspecific in postmenopausal women. Epithelial ovarian tumors are common in adults, and the risk of malignancy increases with age, especially after menopause. So, it is difficult to diagnose adnexal torsion precisely compared with reproductive women, and most cases of adnexal torsion with postmenopausal women are diagnosed as a malignancy preoperatively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982877/the-impact-of-surgical-staging-on-the-prognosis-of-mucinous-borderline-tumors-of-the-ovaries-a-multicenter-study
#19
MULTICENTER STUDY
Kemal Gungorduk, Osman Asicioglu, Elena Ioana Braicu, Jumana Almuheimid, Sevki Goksun Gokulu, Nilufer Cetinkaya, Tayfun Gungor, Gonca Pakay, Elcin Uzmez Telli, Zeliha Firat Cuylan, Tayfun Toptas, Ahmet Bilgi, Ramazan Ozyurt, Elif Agacayak, Aykut Ozdemir, Nuri Yildirim, Salih Taskin, Tufan Oge, Onur Erol, Levent Akman, Anil Turan, Mehmet Sait Icen, Taylan Senol, Ozlem Irak Ovali, Burcu Yucesoy, Ozgu Gungorduk, Osman Temizkan, Muzaffer Sanci, Tayup Simsek, Mehmet Mutlu Meydanli, Mehmet Harma, Levent Yasar, Aysel Derbent Uysal, Ates Karateke, Firat Ortac, Sabit Sinan Ozalp, Jalid Sehouli, Mustafa Zelal Muallem
BACKGROUND/AIM: The purpose of this study was to prove the effect of complete surgical staging of patients with mucinous borderline ovarian tumors (mBOTs) especially appendectomy on progression-free survival (PFS) and overall survival (OS). PATIENTS AND METHODS: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982854/clinicopathological-characteristics-of-ovarian-sclerosing-stromal-tumor-with-an-emphasis-on-tfe3-overexpression
#20
Cheol Keun Park, Hyun-Soo Kim
A sclerosing stromal tumor is a very rare benign sex cord-stromal tumor of the ovary. Because its clinical presentation and imaging findings are similar to those of borderline or malignant epithelial tumors and other sex cord-stromal tumors, accurate preoperative clinical diagnosis can be difficult. The aim of this study was to analyze the clinicopathological characteristics of SSTs and examine the immunohistochemical expression TFE3, which has not been studied in SSTs. Our study cohort consisted of 9 patients diagnosed as having SST; the median age was 36 years...
October 2017: Anticancer Research
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