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https://www.readbyqxmd.com/read/28228232/hormone-receptor-expression-profile-of-low-grade-serous-ovarian-cancers
#1
Marianna Buttarelli, Floriana Mascilini, Gian Franco Zannoni, Alessandra Ciucci, Enrica Martinelli, Flavia Filippetti, Giovanni Scambia, Gabriella Ferrandina, Daniela Gallo
OBJECTIVE: Low-grade serous ovarian carcinomas (LGSOCs) are a histological subtype of epithelial ovarian tumors, accounting for fewer than 5% of all cases of ovarian carcinoma. Due to the chemoresistant nature of this subtype a search for more effective systemic therapies is actively ongoing, hormonal therapy showing some degree of activity in this clinical setting. The present study ought to investigate the hormone receptor status of LGSOCs, as a strategy to provide molecular support for patient-tailored hormonal treatments...
February 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28217671/in-vitro-fertilization-outcome-in-women-with-diminished-ovarian-reserve
#2
Bo Hyon Yun, Gieun Kim, Seon Hee Park, Eun Bee Noe, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee
OBJECTIVE: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patients were evaluated after excluding fertility preservation cases...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28208158/epidemiologic-factors-that-predict-long-term-survival-following-a-diagnosis-of-epithelial-ovarian-cancer
#3
Shana J Kim, Barry Rosen, Isabel Fan, Anna Ivanova, John R McLaughlin, Harvey Risch, Steven A Narod, Joanne Kotsopoulos
BACKGROUND: Various epidemiologic factors have been shown to influence the risk of ovarian cancer development. Given the high fatality associated with this disease, it is of interest to evaluate the association of prediagnostic hormonal, reproductive, and lifestyle exposures with ovarian cancer-specific survival. METHODS: We included 1421 patients with invasive epithelial ovarian cancer diagnosed in Ontario, Canada. Clinical information was obtained from medical records and prediagnostic exposure information was collected by telephone interview...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28184931/elf5-in-epithelial-ovarian-carcinoma-tissues-and-biological-behavior-in-ovarian-carcinoma-cells
#4
Hongchao Yan, Linglin Qiu, Xiaolei Xie, He Yang, Yongli Liu, Xiaoman Lin, Hongxiang Huang
The expression of E74-like factor 5 (ELF5) in epithelial ovarian carcinoma tissues and its effects on biological behavior in ovarian carcinoma cells were assessed in search for a new approach for gene treatment of epithelial ovarian carcinoma. RT-PCR technology was applied to detect the expression of ELF5 mRNA in epithelial ovarian carcinoma (n=49), borderline ovarian epithelial tumor (n=19), benign ovarian epithelial tumor (n=31) and normal ovarian tissues (n=40). Then, we transfected recombinant plasmid pcDNA3...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28179304/imp3-expression-in-borderline-tumors-of-the-ovary
#5
Ahmed El-Balat, Nicole Sänger, Thomas Karn, Sven Becker, Uwe Holtrich, Zelal Muallem, Ruza Arsenic
BACKGROUND/AIM: Borderline ovarian tumors (BOTs) have a less aggressive behavior than invasive epithelial ovarian tumors. Still some patients relapse or succumb to disease. Molecular markers that reliably predict prognosis are lacking. Insulin-like growth factor II mRNA-binding protein (IMP3) has been suggested as a prognostic marker in colorectal, hepatocellular, and ovarian clear-cell carcinomas. MATERIALS AND METHODS: We analyzed the expression of IMP3 by immunohistochemistry in a cohort of 140 BOT and its association with histopathological features...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178764/borderline-ovarian-tumours-balancing-risks-of-recurrence-over-decades
#6
Joanne Morrison
Borderline ovarian tumours account for 10-15% of epithelial tumours. Women are on average 10 years younger than those invasive ovarian epithelial tumours (Morice et al. Lancet Oncol 2012; 13: 103-115) and many will have fertility as a major concern. Many women are unexpectedly diagnosed after conservative surgery, following either cystectomy or unilateral oophorectomy. Frozen section can be useful for informing intra-operative management (Ratnavelu et al. Cochrane Database of Syst Rev 2016; (3): CD010360), informing a conservative surgical approach of a suspicious mass...
February 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28174234/ct-perfusion-as-an-early-biomarker-of-treatment-efficacy-in-advanced-ovarian-cancer-an-acrin-and-gog-study
#7
Chaan Ng, Zheng Zhang, Susanna I Lee, Helga S Marques, Kyle Burgers, Feng Su, Joseph Bauza, Robert S Mannel, Joan Walker, Warner K Huh, Stephen C Rubin, Paul DiSilvestro, Lainie P Martin, John K Chan, Michael A Bookman, Robert L Coleman, Ting-Yim Lee
PURPOSE: ACRIN 6695 was a feasibility study investigating whether CT perfusion (CTP) biomarkers are associated with progression-free survival at 6 months (PFS-6) in patients with advanced ovarian cancer who were treated with carboplatin and either dose-dense (weekly) or conventional (3-weekly) paclitaxel, with optional bevacizumab in the prospective phase III GOG-0262 trial. EXPERIMENTAL DESIGN: ACRIN 6695 recruited participants with residual disease after primary cytoreductive surgery or planned interval cytoreduction following neoadjuvant therapy, to undergo CTP studies before (T0), 3-weeks (T1) and 4-weeks (T2) after chemotherapy initiation...
February 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28166073/ovarian-tumors-pattern-of-histomorphological-types-a-10-years-study-in-a-tertiary-referral-center-and-review-of-literature
#8
A Ghosh, D Ghartimagar, S Thapa, B Sathian, R Narasimhan, O P Talwar
Background Ovarian cancer accounts for 6% of all cancers in females. Among cancers of female genital tract, the incidence of ovarian cancers ranks below only carcinoma of the cervix and the endometrium. Objective To find the frequency of different types of histomorphological types and their association with age, side and size distribution. Method This study is a hospital based retrospective study carried out in the Department of Pathology, Manipal Teaching Hospital over a time period from Jan. 2006 to Sep. 2015...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28160193/correlation-between-tumor-mesothelin-expression-and-serum-mesothelin-in-patients-with-epithelial-ovarian-carcinoma-a-potential-noninvasive-biomarker-for-mesothelin-targeted-therapy
#9
Tatsuya Hanaoka, Kosei Hasegawa, Tomomi Kato, Sho Sato, Akira Kurosaki, Akiko Miyara, Shoji Nagao, Hiroyuki Seki, Masanori Yasuda, Keiichi Fujiwara
BACKGROUND: The cell surface glycoprotein mesothelin is highly expressed in several malignant diseases. Normal mesothelin expression is limited to mesothelial cells lining the pleura, peritoneum, and pericardium, making it a biomarker and an attractive target for cancer therapy. METHODS: We investigated tumor mesothelin expression and serum mesothelin levels in patients with epithelial ovarian cancer or borderline tumors. In total, 161 patients selected from a previous prospective study were analyzed for tumor mesothelin expression using immunohistochemistry and serum mesothelin expression using enzyme-linked immunosorbent assay...
February 3, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28156569/differences-in-self-care-behaviors-by-varying-levels-of-caregiving-intensity-performance-and-well-being-among-family-caregivers-of-patients-with-high-mortality-cancer
#10
Wendy Demark-Wahnefried, Richard A Taylor, Gabrielle Betty Rocque, Andres Azuero, Aras Acemgil, Michelle Y Martin, Meka Astin, Deborah Ejem, Elizabeth Ann Kvale, Karen Heaton, Maria Pisu, Edward E Partridge, Marie Bakitas
: 239 Background: Family caregivers of high-mortality cancer patients perform vital tasks that deter from their own self-care. We aimed to determine differences in self-care behaviors by varying levels of caregiving intensity, well-being, and performance. METHODS: Cross-sectional survey conducted in community settings of 8 cancer centers in AL, FL, and TN. Two-hundred and ninety-four family caregivers of Medicare beneficiaries diagnosed with pancreatic, lung, brain, ovarian, head & neck, hematologic, or stage IV cancer completed measures of self-care behaviors, including health responsibility, physical activity, nutrition, spiritual growth, interpersonal relations, stress management, and sleep; anxiety and depression; health-related quality of life (HRQoL); caregiver competence and preparedness; and decision-making self-efficacy...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28138412/mucinous-borderline-ovarian-tumor-a-case-report-with-diagnostic-insights-on-ultrasound-findings
#11
Anna Szymańska-Dubowik, Marcin Śniadecki, Agnieszka Bianek-Bodzak, Marcin Liro, Edyta Szurowska
Borderline ovarian tumors represent about 10% of all epithelial ovarian cancers, but in contrast to epithelial ovarian cancers, they constitute a group of tumors with a much better prognosis. An assessment of clinical presentation, physical examination, radiological and biochemical findings is necessary to tailor management strategies for patients with ovarian tumors. The article, which is based on a case report, describes different approaches for preoperative diagnosis as well as discusses approaches that might bring some insights on tumor histology...
December 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28131526/role-of-hysterectomy-and-lymphadenectomy-in-the-management-of-early-stage-borderline-ovarian-tumors
#12
Koji Matsuo, Hiroko Machida, Tsuyoshi Takiuchi, Brendan H Grubbs, Lynda D Roman, Anil K Sood, David M Gershenson
OBJECTIVE: To examine survival of women with stage T1 borderline ovarian tumors (BOTs) stratified by hysterectomy and lymphadenectomy status at surgery. METHODS: This is a retrospective study examining The Surveillance, Epidemiology, and End Results Program to identify surgically-treated stage T1 BOTs between 1988 and 2003 (n=4943). Association of surgery patterns and cause-specific survival (CSS) was examined in multivariable analysis. RESULTS: Mean age was 48...
January 26, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28122418/improving-clinical-management-of-women-with-borderline-tumours-a-recurrence-risk-scoring-system-from-a-french-multicenter-study
#13
Lobna Ouldamer, Sofiane Bendifallah, Myriam Nikpayam, Gilles Body, Xavier Fritel, Catherine Uzan, Philippe Morice, Emile Daraï, Marcos Ballester
OBJECTIVE: To develop a risk scoring system (RSS) for predicting recurrence in women with borderline ovarian tumours (BOT). DESIGN: Cohort study of women with BOT SETTING: French multicenter tertiary care centers. POPULATION: 360 women with BOT who received primary surgical treatment between January 2000 and December 2013. METHODS: Clinical and pathological factors impacting recurrence in women with BOT. MAIN OUTCOME MEASURES: Development of a model for the prediction of recurrence in women with BOT...
January 25, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28120491/ephb3-protein-is-associated-with-histological-grade-and-figo-stage-in-ovarian-serous-carcinomas
#14
Weiwei Gao, Qin Zhang, Yan Wang, Jiandong Wang, Shu Zhang
Eph (Erythropoietin-producing human hepatocellular carcinoma cell) is the largest subfamily of receptor tyrosine kinases. Eph receptors and their ephrin ligands are involved in embryonic development and physiological processes. Aberrant expression of Eph/ephrin may contribute to a variety of diseases including cancer. EphB3 is a member of Eph receptors and has been found to play roles in carcinogenesis of some types of human cancer. But, its expression and clinical significance in ovarian serous carcinoma have not been well investigated and are unknown...
February 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28114238/classification-of-ovarian-cancer-surgery-facilitates-treatment-decisions-in-a-gynecological-multidisciplinary-team
#15
Signe Frahm Bjørn, Tine Henrichsen Schnack, Henrik Lajer, Ib Jarle Christensen, Lene Lundvall, Lotte Nedergaard Thomsen, Claus Høgdall
OBJECTIVE: Proper planning of intervention and care of ovarian cancer surgery is of outmost importance and involves a wide range of personnel at the departments involved. The aim of this study is to evaluate the introduction of an ovarian surgery classification (COVA) system for facilitating multidisciplinary team (MDT) decisions. MATERIALS AND METHODS: Four hundred eighteen women diagnosed with ovarian cancers (n = 351) or borderline tumors (n = 66) were selected for primary debulking surgery from January 2008 to July 2013...
February 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28108026/parity-infertility-oral-contraceptives-and-hormone-replacement-therapy-and-the-risk-of-ovarian-serous-borderline-tumors-a-nationwide-case-control-study
#16
Emma L Kaderly Rasmussen, Charlotte Gerd Hannibal, Christian Dehlendorff, Louise Baandrup, Jette Junge, Russell Vang, Robert J Kurman, Susanne K Kjaer
OBJECTIVE: Few studies have examined the risk of an ovarian serous borderline tumor (SBT) associated with parity, infertility, oral contraceptives (OCs), or hormone replacement therapy (HRT), which was the study aim. METHODS: This nationwide case-control study included all women with an SBT diagnosis in Denmark, 1978-2002. SBTs were confirmed by centralized expert pathology review. For each case, 15 age-matched female controls were randomly selected using risk-set sampling...
January 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28102526/hormonal-and-reproductive-factors-and-the-risk-of-ovarian-cancer
#17
Anita Koushik, Anne Grundy, Michal Abrahamowicz, Jocelyne Arseneau, Lucy Gilbert, Walter H Gotlieb, Julie Lacaille, Anne-Marie Mes-Masson, Marie-Élise Parent, Diane M Provencher, Lesley Richardson, Jack Siemiatycki
PURPOSE: Hormone-related factors have been associated with ovarian cancer, the strongest being parity and oral contraceptive use. Given reductions in birth rates and increases in oral contraceptive use over time, associations in more recent birth cohorts may differ. Furthermore, consideration of ovarian cancer heterogeneity (i.e., Type I/II invasive cancers) may contribute to a better understanding of etiology. We examined hormone-related factors in relation to ovarian cancer risk overall, for Type I and Type II cancers, as well as borderline tumors...
January 19, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28101917/imaging-in-gynecological-disease-clinical-and-ultrasound-features-of-invasive-and-non-invasive-malignant-serous-ovarian-tumors
#18
F Moro, C Baima Poma, G F Zannoni, A Vidal Urbinati, T Pasciuto, M Ludovisi, M C Moruzzi, S Carinelli, D Franchi, G Scambia, A C Testa
OBJECTIVES: To describe clinical and ultrasound features of different subclasses of malignant serous ovarian tumors according to the WHO 2014 classification. METHODS: Patients with a histological diagnosis of borderline (BOT), non-invasive and invasive low grade serous carcinomas (LGSC) and high grade serous carcinoma (HGSC), who had undergone preoperative ultrasound examination, were retrospectively identified from two ultrasound centers. The masses were described using the terms of the International Ovarian Tumor Analysis group...
January 19, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28088245/the-value-of-dynamic-contrast-enhanced-mri-in-characterizing-complex-ovarian-tumors
#19
Hai-Ming Li, Jin-Wei Qiang, Feng-Hua Ma, Shu-Hui Zhao
BACKGROUND: The study aimed to investigate the utility of dynamic contrast enhanced MRI (DCE-MRI) in the differentiation of malignant, borderline, and benign complex ovarian tumors. METHODS: DCE-MRI data of 102 consecutive complex ovarian tumors (benign 15, borderline 16, and malignant 71), confirmed by surgery and histopathology, were analyzed retrospectively. The patterns (I, II, and III) of time-signal intensity curve (TIC) and three semi-quantitative parameters, including enhancement amplitude (EA), maximal slope (MS), and time of half rising (THR), were evaluated and compared among benign, borderline, and malignant ovarian tumors...
January 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28078436/adhering-to-the-2014-who-terminology-on-borderline-ovarian-tumors
#20
Jaime Prat
No abstract text is available yet for this article.
February 2017: Virchows Archiv: An International Journal of Pathology
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