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Borderline ovarian

Kamleshsingh Shadhu, Dadhija Ramlagun, Kai Zhu, Yao Zhang, Chen Chen, Di Xi, Jundong Zhu, Chenkui Miao, Yichun Wang, Chao Qin
Ovarian epithelial type tumors of the testis have been a rare entity in clinic. Its' awareness and management remain a clinical challenge. We described a case of an 18-year-old, obese, boy who presented with scrotal enlargement. He underwent eversion of tunica vaginalis and resection of epidydimal mass. The histology of the resected sample showed ovarian epithelial type borderline tumor. We believe this case helps to strengthen awareness and management of this rare disease.
March 12, 2018: Urology
Julia Caroline Radosa, Marc Philipp Radosa, Pascal Albert Schweitzer, Ingolf Juhasz-Boess, Stefan Rimbach, Erich-Franz Solomayer
PURPOSE: The purpose of this survey was to assess the opinions of members of the German Society of Gynecologic Endoscopy (AGE) regarding the laparoscopic treatment of ovarian malignancies and current practice at their institutions. METHODS: Between February and October 2015, the AGE sent an anonymous online survey via mail to its members. The questionnaire solicited participants' opinions about the laparoscopic treatment of ovarian cancers according to T stage and borderline tumors, and information about current practice at their institutions...
March 8, 2018: Archives of Gynecology and Obstetrics
Dominique Koensgen, Martin Weiss, Kathrin Assmann, Sara Y Brucker, Diethelm Wallwiener, Matthias B Stope, Alexander Mustea
BACKGROUND/AIM: Borderline ovarian tumors (BOT) are malignant epithelial ovarian tumors with a very low incidence, therefore lacking sufficient clinical experience in diagnostics and treatment. This study characterized the histology, clinical features, diagnostics and therapy of BOT including patients treated at the Department of Gynecology and Obstetrics of the University Medicine Greifswald. MATERIALS AND METHODS: In this retrospective, single-center study, patients with BOT treated between 1990 and 2010 were analyzed according to their histological and clinical reports...
March 2018: Anticancer Research
Stephanie Nougaret, Yulia Lakhman, Nicolas Molinari, Diana Feier, Chiara Scelzo, Hebert A Vargas, Ramon E Sosa, Hedvig Hricak, Robert A Soslow, Rachel N Grisham, Evis Sala
OBJECTIVE: The objective of our study was to investigate whether the CT features of serous borderline tumors (SBTs) differ from those of low-grade serous carcinomas (LGSCs) and to evaluate if mutation status is associated with distinct CT phenotypes. MATERIALS AND METHODS: This retrospective study included 59 women, 37 with SBT and 22 with LGSC, who underwent CT before primary surgical resection. Thirty of 59 patients were genetically profiled. Two radiologists (readers 1 and 2) independently and retrospectively reviewed CT examinations for qualitative features and quantified total tumor volumes (TTVs), solid tumor volumes (STVs), and solid proportion of ovarian masses...
February 28, 2018: AJR. American Journal of Roentgenology
Elisa Schmoeckel, Thomas Kirchner, Doris Mayr
The differentiation between a primary mucinous ovarian neoplasm and an extra-ovarian metastasis in the ovary is often challenging in the histopathologic practice. Among various ovarian metastases from the gastro-intestinal tract the low-grade appendiceal mucinous neoplasm (LAMN) is an important differential diagnosis to consider particularly in case of pseudomyxoma peritonei. A newly recognized marker in the routine diagnostic of a mucinous neoplasm in the ovary is SATB2 (Special AT-rich sequence-binding protein 2)...
December 14, 2017: Pathology, Research and Practice
Yuuri Hatsuzawa, Masamichi Mizuma, Fuyuhiko Motoi, Tatsuo Hata, Masahiro Iseki, Tatsuyuki Takadate, Hideo Ohtsuka, Naoaki Sakata, Takanori Morikawa, Kei Nakagawa, Hiroki Hayashi, Takeshi Naitoh, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno
Here we report a case of pancreatic cancer(PC)with peritoneal dissemination, underwent conversion surgery following chemotherapy for 2 years. A5 5-year-old woman was referred to our hospital for treatment of PC. Abdominal CT scan revealed 3.0 cm of a pancreatic head tumor with abutment of the portal vein and the hepatic artery, classified as borderline resectable. Staging laparoscopy(SL)showed positive peritoneal cytology(CY). Gemcitabine(Gem)plus S-1 therapy(GS) was performed. Ten months after initial GS, SL revealed the disseminated nodule and positive CY...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Tian Chuan, Song Wei, Tian Xia, Sun Yong
BACKGROUND: The platelet-to-lymphocyte ratio (PLR) has been found to predict clinical outcomes in borderline ovarian tumors and the other genital neoplasms. However, its prognostic value in patients with ovarian cancer remains controversial. The aim of this study was to assess its prognostic value in ovarian cancer. METHODS: We searched MEDLINE, EMBASE and the Cochrane databases to identify studies evaluating the prognostic significance of pretreatment PLR in ovarian cancer...
February 22, 2018: European Journal of Clinical Investigation
Shan Pi, Rong Cao, Jin Wei Qiang, Yan Hui Guo
Background Diffusion-weighted imaging (DWI) and quantitative apparent diffusion coefficient (ADC) values are widely used in the differential diagnosis of ovarian tumors. Purpose To assess the diagnostic performance of quantitative ADC values in ovarian tumors. Material and Methods PubMed, Embase, the Cochrane Library, and local databases were searched for studies assessing ovarian tumors using quantitative ADC values. We quantitatively analyzed the diagnostic performances for two clinical problems: benign vs...
January 1, 2018: Acta Radiologica
Sangita Bohara, Shyama Jain, Nita Khurana, Darilin M Shangpliang, Swapnil Agarwal, Gauri Gandhi
Background: Intraoperative cytology (IOC) is a simple and quick technique with excellent preservation of cellular details. In the present study, we have evaluated the role of IOC by various methods of smear preparation and compared it with frozen section diagnosis. A scoring system was followed for epithelial tumors for characterization and grading on the basis of cellularity, pattern, nuclear, cytoplasmic features, and background details. Materials and Methods: The study was conducted during a time span of 2 years in total 48 cases of ovarian tumors...
January 2018: Journal of Cytology
Hiroaki Takagi, Jinichi Sakamoto, Yasuhiro Osaka, Takeo Shibata, Satoko Fujita, Toshiyuki Sasagawa
INTRODUCTION: Positron emission tomography/computed tomography (PET/CT) involving 18F-fluorodeoxyglucose (FDG) is widely used for systemic cancer and recurrence diagnosis. However, the differential diagnosis of benign and malignant gynaecological tumours according to FDG accumulation is unclear. This study aimed to investigate the intensity of FDG uptake/metabolic activity for the differential diagnosis of benign and malignant gynaecological tumours. METHODS: This study included seven patients with physiological phenomena, 34 with benign tumours, 13 with borderline malignant tumours and 119 with malignant tumours who underwent 18F-FDG PET/CT...
February 5, 2018: Journal of Medical Imaging and Radiation Oncology
Christine Rousset-Jablonski, Fréderic Selle, Elodie Adda-Herzog, François Planchamp, Lise Selleret, Christophe Pomel, Nathalie Chabbert-Buffet, Emile Daraï, Patricia Pautier, Florence Trémollières, Frederic Guyon, Roman Rouzier, Valérie Laurence, Nicolas Chopin, Cécile Faure-Conter, Enrica Bentivegna, Marie-Cécile Vacher-Lavenu, Catherine Lhomme, Anne Floquet, Isabelle Treilleux, Fabrice Lecuru, Sébastien Gouy, Elsa Kalbacher, Catherine Genestie, Thibault de la Motte Rouge, Gwenael Ferron, Mojgan Devouassoux-Shisheboran, Jean-Emmanuel Kurtz, Moise Namer, Florence Joly, Eric Pujade-Lauraine, Michael Grynberg, Denis Querleu, Philippe Morice, Anne Gompel, Isabelle Ray-Coquard
INTRODUCTION: Rare ovarian tumors include complex borderline ovarian tumors, sex-cord tumors, germ cell tumors, and rare epithelial tumors. Indications and modalities of fertility preservation, infertility management and contraindications for hormonal contraception or menopause hormone therapy are frequent issues in clinical practice. A panel of experts from the French national network dedicated to rare gynaecological cancers, and of experts in reproductive medicine and gynaecology have worked on guidelines about fertility preservation, contraception and menopause hormone therapy in women treated for ovarian rare tumors...
February 1, 2018: Bulletin du Cancer
Abbas Agaimy, Evgeny A Moskalev, Wera Weisser, Thorsten Bach, Florian Haller, Arndt Hartmann
Tumors with Müllerian-like serous or mucinous phenotypes originating in the testis and its adnexa are rare neoplasms that have been increasingly recognized in recent years. Cystadenomas with or without ovarian-type stroma, borderline tumors, and adenocarcinomas are the main documented types. Although a handful cases of putative endometrioid adenocarcinomas have been reported, to our knowledge no case of endometrial stromal-type neoplasm has ever been reported in the literature. A 59-year-old man presented with a 2 cm left intrascrotal mass that was found on sonographic examination to arise from the epididymal tail with prominent vascularization...
February 1, 2018: American Journal of Surgical Pathology
Yunfeng Jin, Yi Zou, Linling Wan, Mingming Lu, Ya Liu, Guoqin Huang, Jiandong Wang, Qinghua Xi
Eph receptor‑A1 (EphA1) was the first member of the erythropoietin producing hepatocellular carcinoma (Eph) family of receptor tyrosine kinases. Although the roles of EphA1 in the tumorigenesis of various human cancers have been investigated, few studies have focused on ovarian carcinoma. The present study aimed to explore the profile of EphA1 expression in ovarian carcinomas, to analyzed the association between EphA1 expression and clinicopathologic parameters, and to investigate the roles of overexpressed EphA1 in ovarian cancer cells...
January 31, 2018: Molecular Medicine Reports
Tong Lou, Fang Yuan, Ying Feng, Shuzhen Wang, Huimin Bai, Zhenyu Zhang
Objective: To explore the optimal treatment options for women with borderline ovarian tumors (BOTs). Materials and Methods: The medical records of consecutive patients with BOTs in two academic institutions were retrospectively collected. The pertinent data, including clinicopathological characteristics and, treatment and prognostic information were evaluated. Results: A total of 281 cases of BOTs were included in this analysis. For the entire series, the 5- year disease-free survival (DFS) and overall survival (OS) rates were 91...
December 29, 2017: Oncotarget
Hiroko Matuura, Morikazu Miyamoto, Masashi Takano, Hiroaki Soyama, Tadashi Aoyama, Tomoyuki Yoshikawa, Kento Kato, Takahiro Sakamoto, Mika Kuwahara, Kazuki Takasaki, Hiroki Ishibashi, Hideki Iwahashi, Hitoshi Tsuda, Kenichi Furuya
AIM: To determine whether CD44, which is associated with tumor growth and metastasis, is related to carcinogenesis and prognosis in ovarian mucinous carcinomas (MACs). MATERIALS AND METHODS: Tissue blocks from 71 patients with benign mucinous ovarian tumors were used in the study: 35 were from patients with borderline mucinous ovarian tumors, and 60 from patients with MACs. Immunochemical analysis was performed to evaluate the expression of CD44 and examine its association with tumorigenesis and survival...
February 2018: Anticancer Research
Nur Zaiti Md Arshad, Beng Kwang Ng, Noor Asmaliza Md Paiman, Zaleha Abdullah Mahdy, Rushdan Mohd Noor
Background: Accuracy of diagnosis with intra-operative frozen sections is extremely important in the evaluation of ovarian tumors so that appropriate surgical procedures can be selected. Study design: All patients who with intra-operative frozen sections for ovarian masses in a tertiary center over nine years from June 2008 until April 2017 were reviewed. Frozen section diagnosis and final histopathological reports were compared. Main outcome measures: Sensitivity, specificity, positive and negative predictive values of intra-operative frozen section as compared to final histopathological results for ovarian tumors...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Angela Russo, Austin A Czarnecki, Matthew Dean, Dimple A Modi, Daniel D Lantvit, Laura Hardy, Seth Baligod, David A Davis, Jian-Jun Wei, Joanna E Burdette
The signaling events involved in the onset of ovarian cancer from the fallopian tube epithelium (FTE) are crucial for early detection and treatment of the disease, but they remain poorly defined. Conditional homozygous knockout of PTEN mediated by PAX8-cre recombinase was sufficient to drive endometrioid and serous borderline ovarian carcinoma, providing the first model of FTE-derived borderline tumors. In addition, heterozygous PTEN deletion in the FTE resulted in hyperplasia, providing a model to study early events of human ovarian pathogenesis...
January 25, 2018: Oncogene
F Liu, D H Hu, Y F Zhang, B Wang, K Huang, C Y Wang, X Y Xia
Objective: To study tumors and fertility outcomes after fertility-sparing surgical treatment with borderline ovarian tumors (BOT). Methods: One hundred and nineteen patients with BOT enrolled from 3 hospitals between January 2004 and January 2017 were analysed retrospectively.The clinical data and follow-up results were obtained and analyzed. Results: Among the 119 BOT patients, 55 patients underwent fertility-sparing surgery.The median age was 43 years (interquartile range: 15-80 years). There were 103 patients (86...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jianguo Zhao, Caiyan Liu, Jing Liu, Pengpeng Qu
OBJECTIVE: We investigated the short-term outcomes and pregnancy rate after a laparoscopic approach to fertility preservation in patients with borderline ovarian tumors (BOTs). METHODS: Clinic-pathologic variants of patients with BOTs who underwent conservative surgery at the Tianjin Central Hospital of Obstetrics and Gynecology between January 2009 and July 2015 were retrospectively analyzed. RESULTS: Among 211 patients with BOTs, 74 (35...
January 10, 2018: International Journal of Gynecological Cancer
Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Yoshinobu Hirose, Masahide Ohmichi, Yoshifumi Narumi
BACKGROUND: Serous borderline tumor (SBT) of the micropapillary type (SBT-MP) became one of the major pathological SBT diagnoses in addition to typical SBT, and was also defined as "non-invasive" low-gradeserous carcinoma according to the World Health Organization (WHO) classification in 2014. In this study, we investigated the MRI appearance of SBT-MP compared to that of typical SBT in order to identify specific imaging features of SBT-MP that correspond to pathological findings. METHODS: MR images of 6 histologically proven ovarian SBT-MP in four patients and 14 typical SBT in ten patients were reviewed retrospectively...
January 10, 2018: Journal of Ovarian Research
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