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https://www.readbyqxmd.com/read/28078436/adhering-to-the-2014-who-terminology-on-borderline-ovarian-tumors
#1
Jaime Prat
No abstract text is available yet for this article.
January 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28075407/diagnostic-value-of-serum-angiogenesis-markers-in-ovarian-cancer-using-multiplex-immunoassay
#2
Agnieszka Horala, Agata Swiatly, Jan Matysiak, Paulina Banach, Ewa Nowak-Markwitz, Zenon J Kokot
As cancer development involves pathological vessel formation, 16 angiogenesis markers were evaluated as potential ovarian cancer (OC) biomarkers. Blood samples collected from 172 patients were divided based on histopathological result: OC (n = 38), borderline ovarian tumours (n = 6), non-malignant ovarian tumours (n = 62), healthy controls (n = 50) and 16 patients were excluded. Sixteen angiogenesis markers were measured using BioPlex Pro Human Cancer Biomarker Panel 1 immunoassay. Additionally, concentrations of cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) were measured in patients with adnexal masses using electrochemiluminescence immunoassay...
January 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28041594/malignant-and-borderline-epithelial-ovarian-tumors-in-the-pediatric-and-adolescent-population
#3
Dimitrios Nasioudis, Michail Alevizakos, Kevin Holcomb, Steven S Witkin
OBJECTIVES: Malignant and borderline ovarian tumors of epithelial origin are rarely encountered among prepubertal girls and adolescents. The aim of this population-based study was to elucidate their clinicopathological characteristics and prognosis using a multi-institutional tumor registry. STUDY DESIGN AND OUTCOMES: The National Cancer Institute's Surveillance, Epidemiology, and End Results database was accessed and a cohort of females aged <=19years old, diagnosed between 1988 and 2013 with a borderline ovarian tumor (BOT) or a malignant epithelial ovarian carcinoma (EOC) was accessed...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28027973/the-role-of-imaging-tools-for-the-diagnosis-of-borderline-ovarian-tumors-a-systematic-review-and-meta-analysis
#4
REVIEW
Giuliano Moysés Borrelli, Leandro Accardo de Mattos, Marina de Paula Andres, Manoel Orlando da Costa Gonçalves, Rosanne M Kho, Mauricio Simões Abrão
Borderline ovarian tumors (BOTs) are tumors with low malignant potential that occurs most often in young women. Its preoperative diagnosis can improve surgical strategy and reproductive approach. This study systematically reviews the literature for the accuracy of transvaginal ultrasound (TVUS), magnetic resonance (MRI) and computed tomography (CT) in the diagnostic of borderline ovarian tumors. We conducted a search in Pubmed/Medline of articles in English of the last 5 years and included 14 studies for systematic review and 9 of them in the meta-analysis...
December 24, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28025670/ovarian-borderline-tumors-in-the-2014-who-classification-evolving-concepts-and-diagnostic-criteria
#5
REVIEW
Steffen Hauptmann, Katrin Friedrich, Raymond Redline, Stefanie Avril
Borderline ovarian tumors (BOT) are uncommon but not rare epithelial ovarian neoplasms, intermediate between benign and malignant categories. Since BOT were first identified >40 years ago, they have inspired controversies disproportionate to their incidence. This review discusses diagnostic criteria for the histologic subtypes of BOT, highlighting areas of diagnostic challenges, ongoing controversies, and changes in terminology implemented by the recent 2014 WHO Classification of Tumours of the Female Genital Organs...
December 27, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28006819/better-resource-utilisation-and-quality-of-care-for-ovarian-cancer-patients-using-internet-based-pathology-review
#6
S Kommoss, F Kommoss, J Diebold, S Lax, D Schmidt, A Staebler, A du Bois, J Pfisterer
BACKGROUND: The current literature indicates that a considerable number of patients in ovarian carcinoma clinical trials have histopathological diagnoses in conflict with inclusion criteria. It has been suggested that specialised pathology review prior to randomisation should become the standard procedure in study protocols. We hypothesised that our new, internet-based high-throughput infrastructure would be capable of providing specialised pathology review within 10 working days (w.d...
December 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/28004457/clinical-and-ultrasound-characteristics-of-surgically-removed-adnexal-lesions-with-a-largest-diameter-%C3%A2-2-5-cm-a-pictorial-essay
#7
A Di Legge, P Pollastri, R Mancari, M Ludovisi, F Mascilini, D Franchi, D Jurkovic, M E Coccia, D Timmerman, G Scambia, A Testa, L Valentin
OBJECTIVES: The aim was to describe the ultrasound characteristics, the indications for surgery and the histological diagnoses of surgically removed adnexal masses with largest diameter <2.5 cm ("very small tumors"), to estimate sensitivity and specificity with regard to malignancy of subjective assessment of ultrasound images of very small tumors, and to present a gallery of ultrasound images of surgically removed very small tumors especially those causing diagnostic difficulties...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27989810/needleoscopic-conservative-staging-of-borderline-ovarian-tumor
#8
Salvatore Gueli Alletti, Cristiano Rossitto, Emanuele Perrone, Stefano Cianci, Ilaria De Blasis, Anna Fagotti, Giovanni Scambia
STUDY OBJECTIVE: to investigate safeness and technical feasibility of needleoscopic fertility sparing staging of borderline ovarian tumor Design: video article and review of the literature SETTING: The patient was a 29 years old women affected by right ovarian cyst suspected for BOT at preoperative MRI and US due to the presence of a right unilocular ovarian cyst with a papillary projection. Informed consent for abdominal or laparoscopic approach was obtained from the patient in accordance with the local legislation...
October 27, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27987343/mature-cystic-teratoma-coexisting-with-clear-cell-carcinoma-in-the-ovary
#9
Koki Shimura, Mariko Matsumoto, Takuya Sugahara, Takuro Yamamoto, Nozomi Ogiso, Yoji Urata, Tomoharu Okubo
Mature cystic teratoma (MCT) is the most common benign ovarian tumor; clear-cell carcinoma (CCC) is a relatively common malignant ovarian tumor in Japan, but there are few reports on the coexistence of MCT and CCC. Here we report a case of simultaneous MCT and CCC in the ovary and review the relevant literature. The patient was a 49-year-old woman. A 5-cm MCT was found in the left ovary on initial gynecological examination, and she was referred to hospital for treatment because it was expanding. Magnetic resonance imaging showed a multilocular cystic tumor 16 × 10 × 9...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27984374/cd56-neural-cell-adhesion-molecule-expression-in-ovarian-carcinomas-association-with-high-grade-and-advanced-stage-but-not-with-neuroendocrine-differentiation
#10
Hans-Christian Bösmüller, Philipp Wagner, Deborah Lam Pham, Anna K Fischer, Karen Greif, Christine Beschorner, Bence Sipos, Falko Fend, Annette Staebler
OBJECTIVE: Neural cell adhesion molecule (CD56) has been proposed as a potential marker for neuroendocrine differentiation in carcinomas, together with synaptophysin and chromogranin A. However, CD56 immunoreactivity by itself can be found in a broad variety of tumors, including ovarian neoplasms. CD56 has recently been suggested as a potential target for antibody-based therapy. However, for ovarian carcinoma, there is only limited data available regarding the pattern of CD56 immunoreactivity, coexpression of neuroendocrine markers, and correlation with histological types and clinical parameters...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27976698/epithelial-ovarian-carcinoma-diagnosis-by-desorption-electrospray-ionization-mass-spectrometry-imaging
#11
Maria Luisa Dória, James S McKenzie, Anna Mroz, David L Phelps, Abigail Speller, Francesca Rosini, Nicole Strittmatter, Ottmar Golf, Kirill Veselkov, Robert Brown, Sadaf Ghaem-Maghami, Zoltan Takats
Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption electrospray mass spectrometry imaging (DESI-MSI) generates spatially resolved metabolic profiles of tissues and supports an objective investigation of tumour biology. In this study, various ovarian tissue types were analysed by DESI-MSI and co-registered with their corresponding haematoxylin and eosin (H&E) stained images...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974934/ultrasound-diagnostic-of-mesonephric-paraovarian-cyst-case-report
#12
Bohîlțea Re, Cîrstoiu Mm, Turcan N, Ionescu Ca
Paraovarian cysts are a rare pathology, constituting 10-20% of the adnexal masses. The origin can be represented by paramesonephric ducts (Hydatid cysts of Morgagni), vestiges of mesonephric ducts also represented by mesothelium, or neoplastic (cystadenomas or cystadenofibromas) that are mostly benign. Borderline or malignant paraovarian tumors are encountered less often. This article presents a case of paraovarian cyst in a 37-year-old patient, with a history of 2 pregnancies, completed by cesarean. The patient sought medical attention for an asymptomatic voluminous ovarian cyst, detected in a routine ultrasound scan...
July 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27959888/smoking-and-risk-of-ovarian-cancer-by-histological-subtypes-an-analysis-among-300%C3%A2-000-norwegian-women
#13
Idlir Licaj, Bjarne Koster Jacobsen, Randi Marie Selmer, Gertraud Maskarinec, Elisabete Weiderpass, Inger Torhild Gram
BACKGROUND: We prospectively investigated the association between different measures of smoking exposure and the risk of serous, mucinous, and endometrioid ovarian cancers (OC) in a cohort of more than 300 000 Norwegian women. METHODS: We followed 300 398 women aged 19-67 years at enrolment until 31 December 2013 for OC incidence through linkage to national registries. We used Cox proportional hazards models with attained age as the underlying time scale to estimate multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for relevant confounders...
December 13, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27941069/pelvic-inflammatory-disease-and-the-risk-of-ovarian-cancer-and-borderline-ovarian-tumors-a-pooled-analysis-of-13-case-control-studies
#14
Christina B Rasmussen, Susanne K Kjaer, Vanna Albieri, Elisa V Bandera, Jennifer A Doherty, Estrid Høgdall, Penelope M Webb, Susan J Jordan, Mary Anne Rossing, Kristine G Wicklund, Marc T Goodman, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Robert P Edwards, Joellen M Schildkraut, Andrew Berchuck, Sara H Olson, Lambertus A Kiemeney, Leon F A G Massuger, Steven A Narod, Catherine M Phelan, Hoda Anton-Culver, Argyrios Ziogas, Anna H Wu, Celeste L Pearce, Harvey A Risch, Allan Jensen
Inflammation has been implicated in ovarian carcinogenesis. However, studies investigating the association between pelvic inflammatory disease (PID) and ovarian cancer risk are few and inconsistent. We investigated the association between PID and the risk of epithelial ovarian cancer according to tumor behavior and histotype. We pooled data from 13 case-control studies, conducted between 1989 and 2009, from the Ovarian Cancer Association Consortium (OCAC), including 9,162 women with ovarian cancers, 2,354 women with borderline tumors, and 14,736 control participants...
January 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27922976/intraoperative-frozen-section-of-ovarian-tumors-a-6-year-review-of-performance-and-potential-pitfalls-in-an-australian-tertiary-referral-center
#15
Rhett Morton, Lyndal Anderson, Jonathan Carter, Selvan Pather, Samir A Saidi
OBJECTIVES: Intraoperative frozen section (IFS) offers a rapid test to guide the extent of surgery, which is essential for optimal treatment of ovarian cancer. This study evaluated the diagnostic performance and influence of IFS in the surgical management of ovarian tumors. METHODS: A retrospective review was conducted of IFS of adnexal lesions from 2008 to 2013, with diagnoses classified as benign, borderline, or malignant. The diagnostic performance of IFS was calculated, with a focus on primary epithelial tumors...
January 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27922289/assessing-the-risk-of-clinical-and-pathologic-factors-for-relapse-of-borderline-ovarian-tumours
#16
Chung Chang, Jiabin Chen, Wei-An Chen, Szu-Pei Ho, Wen Shiung Liou, An Jen Chiang
The objective of this study was to identify clinical and pathologic factors that are significant to relapse in borderline ovarian tumours (BOT). All patients with BOTs from 1997 to 2012 in our institute were identified. 115 patients were included in the study. The Cox proportional hazards model was used to identify significant factors. The median age was 42 years (range 14-85 years). The majority of the patients were at FIGO stage I (88.7%), and most of the patients had mucinous histology (66.1%), reflecting the predominant distribution of mucinous BOTs in East Asia...
December 6, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27904170/twenty-five-year-old-woman-with-bilateral-borderline-ovarian-tumour-desiring-to-preserve-fertility-case-report-and-literature-review-on-the-current-state-of-fertility-preservation-in-women-with-borderline-ovarian-tumours
#17
S Findeklee, L Lotz, K Heusinger, I Hoffmann, R Dittrich, M W Beckmann
Borderline ovarian tumours are semimalignant tumours occurring unilaterally or bilaterally with a peak incidence among women of reproductive age. Since the affected women often wish to preserve fertility, particular precautions must be taken when counselling the patient and obtaining consent prior to planning an individual treatment. Options for preserving fertility include an organ-sparing surgical procedure and cryopreservation of oocytes and/or ovarian tissue. In this article, we report on a 25-year-old patient with a bilateral seromucinous borderline tumour who desired all fertility-preserving options...
November 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27900026/clinical-implication-of-tiam1-overexpression-in-the-prognosis-of-patients-with-serous-ovarian-carcinoma
#18
Huiwen Li, Xuelian Cui, Dingbao Chen, Yang Yang, Junjie Piao, Zhenhua Lin, Guanghai Yan, Danhua Shen
T lymphoma invasion and metastasis 1 (Tiam1), a guanine nucleotide exchange factor, was originally identified as an invasion- and metastasis-inducing gene in T lymphoma cells. High expression levels of the human Tiam1 gene have been found in numerous human malignancies, suggesting a potential role as a modifier of tumor initiation and progression. However, little is known about the status of Tiam1 in ovarian carcinoma. The present study aimed to investigate the clinicopathological significance of high Tiam1 expression in serous ovarian carcinoma...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27892434/clinicomorphological-spectrum-of-ovarian-cystic-lesions
#19
R Dhakal, R Makaju, R Bastakoti
Background Ovarian cysts, which present as neoplastic and non-neoplastic lesions, are the most common gynaecological cause of hospital admissions. Early diagnosis is difficult due to asymptomatic nature. Clinical, radiological and gross examination alone cannot distinguish benign from malignant lesions, hence, histopathological examination is important for diagnostic, therapeutic and prognostic approach. Objective The objective of the study is to analyze the spectrum of ovarian cystic lesions with their clinico-morphorgical features...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27891341/clinicopathological-study-of-surface-epithelial-tumours-of-the-ovary-an-institutional-study
#20
Nalini Modepalli, Suguna Belur Venugopal
INTRODUCTION: It is an established fact that tumours of ovary inherit a spectrum of histogenetic background, the variety being more than any other organ. Surface epithelial stromal tumours of ovary being the most common type of ovarian tumours form a complicating and baffling subject in the history of oncology and hence, are an interesting topic for study. AIM: The aim of this study was to categorize the surface epithelial tumours of ovary into benign, borderline and malignant, to study their clinical and histopathological pattern and to compare their incidences with other studies...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
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