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Borderline ovarian carcinoma

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https://www.readbyqxmd.com/read/28906309/cancer-stem-cell-related-marker-nanog-expression-in-ovarian-serous-tumors-a-clinicopathological-study-of-159-cases
#1
Nataša Kenda Šuster, Snježana Frković Grazio, Irma Virant-Klun, Ivan Verdenik, Špela Smrkolj
OBJECTIVE: The objectives of this study were to assess cancer stem cell-related marker NANOG expression in ovarian serous tumors and to evaluate its prognostic significance in relation to ovarian serous carcinoma. METHODS: NANOG protein expression was immunohistochemically evaluated in the ovarian tissue microarrays of 20 patients with benign ovarian serous tumors, 30 patients with borderline ovarian serous tumors, and 109 patients with ovarian serous carcinomas, from which 106 were of high-grade and 3 of low-grade morphology Immunohistochemical reaction was scored according to signal intensity and the percentage of positive cells in tumor samples...
September 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28873354/mutation-of-nras-is-a-rare-genetic-event-in-ovarian-low-grade-serous-carcinoma
#2
Deyin Xing, Yohan Suryo Rahmanto, Felix Zeppernick, Charlotte G Hannibal, Susanne K Kjaer, Russell Vang, Ie-Ming Shih, Tian-Li Wang
Activating mutations involving the members of the RAS signaling pathway, including KRAS, NRAS, and BRAF, have been reported in ovarian low-grade serous carcinoma and its precursor lesion, serous borderline tumor (SBT). Whether additional genetic alterations in the RAS oncogene family accumulate during the progression of serous borderline tumor (SBT) to invasive low grade serous carcinoma (LGSC) remains largely unknown. While mutations of KRAS and BRAF occur at a very early stage of progression, even preceding the development of SBT, additional driving events, such as NRAS mutations, have been postulated to facilitate progression...
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28863071/an-ovarian-adenocarcinoma-with-combined-low-grade-serous-and-mesonephric-morphologies-suggests-a-m%C3%A3-llerian-origin-for-some-mesonephric-carcinomas
#3
David B Chapel, Nancy M Joseph, Thomas Krausz, Ricardo R Lastra
Mesonephric carcinomas are rare adenocarcinomas of the female genital tract that occur most commonly in the uterine cervix. They are classically thought to arise from benign mesonephric remnants, and are rarely reported at other sites in the gynecologic tract. Here we present an interesting biphenotypic ovarian adenocarcinoma with intimately associated but distinct components of both low-grade serous carcinoma and mesonephric-like carcinoma. A serous borderline tumor was present adjacent to the invasive carcinoma, and no benign mesonephric precursors were identified...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28804555/imp3-is-upregulated-in-primary-ovarian-mucinous-carcinoma-and-promotes-tumor-progression
#4
Qin Zhu, Yuqing Qu, Qiongyan Zhang, Linghui Lu, Weiwei Weng, Hao Zhang, Lihong Zhang, Yan Ning, Yiqin Wang
OBJECTIVE: Primary ovarian mucinous tumors progress from benign adenoma to borderline tumors to invasive mucinous carcinoma. A proper differential diagnosis is crucial to discriminate malignancies at the early stages of disease. However, few biomarkers are clinically available. We designed this study to analyze the clinical application of the oncogene IMP3 in monitoring early malignancies in ovarian primary mucinous tumors. METHODS: We collected 250 samples of ovarian primary mucinous tumors along with the corresponding clinicopathological information between 2009 and 2015 at the Gynecology and Obstetrics Hospital of Fudan University and performed immunochemical assays...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28800010/cell-polarity-reversal-distinguishes-true-micropapillary-growth-from-retraction-artifact-in-invasive-urothelial-carcinoma
#5
Yiang Hui, Kara A Lombardo, M Ruhul Quddus, Andres Matoso
Focal micropapillary features in invasive urothelial carcinoma is sometimes difficult to distinguish from retraction artifact morphologically. Cell polarity reversal has been demonstrated in micropapillary tumors by epithelial membrane antigen (EMA) immunostaining. We have previously described the use of E-cadherin as a cell polarity marker in ovarian micropapillary serous borderline tumors. The aim of this study was to evaluate the utility of immunohistochemistry for EMA and E-cadherin in differentiating micropapillary urothelial carcinoma from retraction artifact...
August 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28782867/imaging-in-gynecological-disease-11-clinical-and-ultrasound-features-of-mucinous-ovarian-tumors
#6
F Moro, G F Zannoni, D Arciuolo, T Pasciuto, S Amoroso, F Mascilini, S Mainenti, G Scambia, A C Testa
OBJECTIVE: To describe the clinical and ultrasound findings in patients with mucinous ovarian tumors. METHODS: In this retrospective study, women with a histological diagnosis of mucinous ovarian tumor who had undergone preoperative ultrasound examination were identified from the database of a single ultrasound center. The histological examination was performed by the same pathologist in all cases, and the ultrasound appearance of the tumors was described using the terms and definitions of the International Ovarian Tumor Analysis group...
August 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28752709/-expression-and-clinical-significance-of-dnajb11-in-epithelial-ovarian-cancer
#7
Yao Guorong, F U Yunfeng, L I Yanli, Zhou Caiyun, L V Weiguo
Objective: To study the expression of DNAJB11 protein in epithelial ovarian cancer tissues and its clinical significance. Methods: Immunohistochemistry was used to examine DNAJB11 expressions in 105 tissue specimens of ovarian epithelial carcinoma, 23 normal ovarian tissues, 17 tissues of benign tumor, and 13 tissues of of borderline tumor. The correlations between protein expression and clinicopathological factors were analyzed by Chi square test.The correlations between protein expression and survival were analyzed by Kaplan-Meier and Cox regression...
March 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28706410/coexisting-brenner-tumor-and-endometrial-carcinoma
#8
Mitakshara Sharma, Babita Khangar, Varuna Mallya, Nita Khurana, Sangeeta Gupta
Brenner tumor is a rare ovarian neoplasm that is seen in women of the fifth to sixth decade. Classified as benign, borderline, and malignant, these tumors may be associated with estrogen production, thus altering the estrogen-progesterone ratio. High estrogen stimulates the endometrium and this is responsible for producing various pathologies, namely, hyperplasia, atypia, and carcinoma. Very few case reports have been published highlighting the same. A case report is being presented here of a coexisting Brenner tumor and well-differentiated endometrial carcinoma in a 55-year-old nulliparous postmenopausal woman...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28700429/mucosal-proliferations-in-completely-examined-fallopian-tubes-accompanying-ovarian-low-grade-serous-tumors-neoplastic-precursor-lesions-or-normal-variants-of-benign-mucosa
#9
Rebecca J Wolsky, Matt A Price, Charles J Zaloudek, Joseph T Rabban
Malignant transformation of the fallopian tube mucosa, followed by exfoliation of malignant cells onto ovarian and/or peritoneal surfaces, has been implicated as the origin of most pelvic high-grade serous carcinoma. Whether a parallel pathway exists for pelvic low-grade serous tumors [ovarian serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC)] remains to be fully elucidated. The literature is challenging to interpret due to variation in the diagnostic criteria and terminology for cytologically low-grade proliferations of the fallopian tube mucosa, as well as variation in fallopian tube specimen sampling...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700421/atypical-proliferative-borderline-serous-tumor-in-the-brain-a-case-report
#10
Deyin Xing, Erik G Jenson, Christopher A Zwick, Fausto J Rodriguez, Robert J Kurman
A 59-year-old woman with a remote history of invasive ductal carcinoma of the breast was found on a follow-up computed tomography scan of her brain to have a 1-cm lesion in the right frontal lobe in 2008. In the ensuing years, before her current admission, multiple imaging studies of the brain revealed that the lesion was stable and it was, therefore, interpreted as a small area of encephalomalacia related to a thrombosed cortical vein, a cavernoma, or treated metastatic breast cancer. In 2013, the patient underwent a bilateral salpingo-oophorectomy for ovarian tumors that were diagnosed as bilateral serous cystadenofibromas...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28693233/pre-operative-evaluation-of-circulating-kl-6-levels-as-a-biomarker-for-epithelial-ovarian-carcinoma-and-its-correlation-with-tumor-muc1-expression
#11
Sho Sato, Tomomi Kato, Kenji Abe, Tatsuya Hanaoka, Yuri Yano, Akira Kurosaki, Masanori Yasuda, Tetsuo Sekino, Keiichi Fujiwara, Kosei Hasegawa
Krebs von den Lungen-6 (KL-6), a mucinous sialylated sugar chain on human mucin-1 glycoprotein (MUC1), is a diagnostic marker for interstitial lung diseases. Furthermore, elevated serum KL-6 levels have been observed in certain malignant tumor types of epithelial origin. The expression of MUC1 has been observed in patients with epithelial ovarian cancer (EOC) and is considered a potential therapeutic target. In the present study, KL-6 serum levels were investigated in patients clinically suspected of having malignant ovarian tumors...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28689208/staging-with-unilateral-salpingo-oophorectomy-and-expert-pathological-review-result-in-no-recurrences-in-a-series-of-81-intestinal-type-mucinous-borderline-ovarian-tumors
#12
Kobe Dewilde, Philippe Moerman, Karin Leunen, Frederic Amant, Patrick Neven, Ignace Vergote
OBJECTIVE: Recent studies suggest that mucinous borderline ovarian tumors (MBOTs) belong to a high-risk group that is more likely to develop an invasive recurrence. The objective is to determine these risk factors. METHODS: A monocentric retrospective review of all consecutive patients with intestinal-type MBOT diagnosed between 1993 and 2013. All tumors were evaluated by one pathologist without knowledge of clinical outcome. Extensive surgical staging and pathological tumor sampling (1 block/cm diameter in tumors <10 cm and 2 blocks/cm diameter in tumors >10 cm) were performed in all cases...
July 8, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28639280/mutational-profiles-of-brenner-tumors-show-distinctive-features-uncoupling-urothelial-carcinomas-and-ovarian-carcinoma-with-transitional-cell-histology
#13
Nicole Pfarr, Silvia Darb-Esfahani, Jonas Leichsenring, Eliane Taube, Melanie Boxberg, Ioana Braicu, Moritz Jesinghaus, Roland Penzel, Volker Endris, Aurelia Noske, Wilko Weichert, Peter Schirmacher, Carsten Denkert, Albrecht Stenzinger
Brenner tumors (BT) are rare ovarian tumors encompassing benign, borderline, and malignant variants. While the histopathology of BTs and their clinical course is well described, little is known about the underlying genetic defects. We employed targeted next generation sequencing to analyze the mutational landscape in a cohort of 23 BT cases (17 benign, 2 borderline, and 4 malignant) and 3 ovarian carcinomas with transitional cell histology (TCC). Copy number variations (CNV) were validated by fluorescence in-situ hybridization (FISH) and quantitative PCR-based copy number assays...
October 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28612563/-expression-and-clinical-significance-of-numb-and-p53-proteins-in-epithelial-ovarian-carcinoma
#14
Min Xu, Hong-Ju He, Huan Zhang, Ao Wang, Jie Chen
OBJECTIVES: To investigate the expression and clinical significance of Numb and P53 proteins in epithelial ovarian carcinoma. METHODS: We co-tested the expressions of Numb and P53 proteins in epithelial ovarian tissues by immunohistochemistry, including 20 cases of normal tissues, 29 cases of benign tumors, 35 cases of borderline ovarian tumors and 87 cases of epithelial ovarian carcinoma. Their clinical significance was analyzed. RESULTS: The positive expression rates of Numb protein in normal ovarian tissues, benign ovarian tumors, borderline ovarian tumors and epithelial ovarian carcinoma were 5%, 13...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28598117/-expression-level-of-membrane-associated-proteins-numb-in-epithelial-ovarian-carcinoma-and-its-relationship
#15
Hong Jing, Xiao-Yu Liu, Ya-Li Chen, Li-Ping Bai, Ai Zheng
OBJECTIVES: To explore the expression level of membrane-associated protein Numb in epithelial ovarian carcinoma and its relationship with ovarian cancer stem cell markers CD117,CD133,acetaldehyde dehydrogenase 1(ALDH1). METHODS: A total of 136 patients who had ovarian tumors and 22 patients who had not ovarian tumors in Department of Gynaecology and Obstetrics,West China Second University Hospital,Sichuan University were chosen as the study subjects.According to the histopathologic examination results,they were divided into epithelial ovarian carcinoma group (n=92),ovarian borderline tumor group (n=23),ovarian benign tumor group (n=21) and normal ovary group (n=22)...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28571149/vegf-expression-to-support-targeted-therapy-in-ovarian-surface-epithelial-neoplasms
#16
Sudeshna Mukherjee, Mallika Pal, Susmita Mukhopadhyay, Indranil Das, Rathin Hazra, Suman Ghosh, Rajib Kumar Mondal, Runa Bal
INTRODUCTION: Vascular Endothelial Growth Factor (VEGF), a promoter of angiogenesis, is a promising target for anti-angiogenic therapy in ovarian cancer. In our study, we examined the expression of VEGF in the spectrum of epithelial ovarian neoplasms (benign, borderline and malignant) by Immunohistochemistry (IHC). AIM: Diagnosing ovarian epithelial neoplasms, examining the expression of VEGF in benign, borderline and malignant neoplasms and correlating it with histological grade and stage of malignant cases...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28523039/borderline-tumors-of-the-ovary-a-clinicopathological-study
#17
Samia Yasmeen, Abdul Hannan, Fareeha Sheikh, Amir Ali Syed, Neelam Siddiqui
OBJECTIVE: To report experience with borderline ovarian tumors (BOTs) in a developing country like Pakistan with limited resources and weak database of health system. METHODS: Patients with BOTs managed at Shaukat Khanum Cancer hospital, Lahore, Pakistan from 2004 to 2014 were included and reviewed retrospectively. Data was recorded on histopathological types, age, CA-125, stage of disease, treatment modalities and outcomes. RESULTS: Eighty-six patients with BOT were included with a median age of 35 years...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28500412/-hereditary-breast-and-ovarian-cancer
#18
REVIEW
S F Lax
Hereditary breast and ovarian carcinomas are frequently caused by germline mutations of the BRCA1 and BRCA2 genes (BRCA1/2 syndromes) and are often less associated with other hereditary syndromes such as Li-Fraumeni and Peutz-Jeghers. The BRCA1/2 proteins have a special role in DNA repair. Therefore, loss of function due to mutation causes an accumulation of mutations in other genes and subsequent tumorigenesis at an early age. BRCA1/2 mutations are irregularly distributed over the length of the genes without hot spots, although special mutations are known...
May 12, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28493257/expression-of-p53-and-selected-proliferative-markers-ki-67-mcm3-pcna-and-topoisomerase-ii%C3%AE-in-borderline-ovarian-tumors-correlation-with-clinicopathological-features
#19
Klaudiusz Ciepliński, Maciej Jóźwik, Anna Semczuk-Sikora, Marek Gogacz, Dorota Lewkowicz, Atanas Ignatov, Andrzej Semczuk
BACKGROUND: The expression of p53 has been studied not only in primary human ovarian carcinomas, but also in borderline ovarian tumors, however, the results were discordant. Expression patterns of proteins involved in cell proliferation and apoptosis have been investigated in various human neoplasms, including female genital tract neoplasms. OBJECTIVE: The aim of this investigation was to assess the staining pattern and immunolocalization of p53 and selected proliferative markers (Ki-67, MCM3, PCNA, and topoisomerase IIα) in borderline ovarian tumors (BOTs)...
May 11, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28488545/determination-of-braf-v600e-ve1-protein-expression-and-braf-gene-mutation-status-in-codon-600-in-borderline-and-low-grade-ovarian-cancers
#20
Pawel Sadlecki, Pawel Walentowicz, Magdalena Bodnar, Andrzej Marszalek, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Epithelial ovarian tumors are a group of morphologically and genetically heterogeneous neoplasms. Based on differences in clinical phenotype and genetic background, ovarian neoplasms are classified as low-grade and high-grade tumor. Borderline ovarian tumors represent approximately 10%-20% of all epithelial ovarian masses. Various histological subtypes of ovarian malignancies differ in terms of their risk factor profiles, precursor lesions, clinical course, patterns of spread, molecular genetics, response to conventional chemotherapy, and prognosis...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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