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JOURNAL ARTICLE
Gilles Crochet, Gloria Iacoboni, Audrey Couturier, Emmanuel Bachy, Josu Iraola-Truchuelo, Thomas Gastinne, Guillaume Cartron, Tom Fradon, Bastien Lesne, Mi Kwon, Romain Gounot, Nuria Martínez-Cibrian, Cristina Castilla-Llorente, Pau Abrisqueta, Manuel Guerreiro, Clémentine Sarkozy, José María Aspa-Cilleruelo, Vincent Camus, Stéphanie Guidez, Adrien Chauchet, Eric Deconinck, Krimo Bouabdallah, Francesc Bosch, Pere Barba, Franck Morschhauser, Houot Roch
In this retrospective study, CAR T-cells remained effective in relapsed/refractory LBCL patients after prior exposure to bispecific antibodies (BsAbs) targeting different antigens. These results are relevant to clinical practice, particularly given the increasing use of BsAbs in earlier treatment lines.
April 24, 2024: Blood
#2
JOURNAL ARTICLE
Karine Lino Rodrigues, Patrícia de Oliveira da Silva Scaranni, Evelyn Nunes Goulart da Silva Pereira, Vivian Vieira Dias da Silva, Raquel Rangel Silvares, Beatriz Peres de Araujo, Cristina Castilho, Maria Inês Schmidt, Maria de Jesus Mendes da Fonseca, Rosane Harter Griep, Anissa Daliry
INTRODUCTION: Hair cortisol level has recently been identified as a promising marker for detecting long-term cortisol levels and a marker of hypothalamic-pituitary-adrenal cortex (HPA) axis activity. However, research on the association between obesity and an altered cortisol metabolism remains controversial. OBJECTIVE: This study aimed to investigate the relationship between hair cortisol levels and overweight and obesity in participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)...
2024: Frontiers in Endocrinology
#3
JOURNAL ARTICLE
Patrícia Froes Meyer, Rafaella Rêgo Maia, Eneida de Morais Carreiro, Rodrigo Marcel Valentim da Silva, Stephany Luanna Queiroga Farias, Felice Picariello, Carla Érica Lima Medeiros, Danielli Malta Prata E Silva, Daniela Silva Salgado Barros, Vanessa Siqueira Roque, Lucas Peres de Sousa
The sample comprised 44 volunteers who had undergone some surgical procedure and were equally divided into four groups. G1 started the therapy 24 h after the surgical procedure with the device off. G2 followed the same time pattern, 24 h, but with the device turned on. G3 and G4 started therapy three days after the surgical procedure; in G3, the device was turned off, and in G4, the device remained on during therapy; each session lasted 30 min, using 660 nm (red), energy 180 J. For all groups, the therapy started with daily use for seven days and followed the interval use of three times a week until completed 21 days...
April 22, 2024: Lasers in Medical Science
#4
JOURNAL ARTICLE
E A Melnikova, E Yu Starkova, A V Semenkov, V Yu Litau, D A Tulskih
Surgery is one of the leading treatment methods of patients with primary or recurrent malignant neoplasms in the thoracic or abdominal cavity. Extensive abdominal interventions are accompanied by such adverse outcomes as blood loss, hypoxia, inflammation, blood clotting abnormality, emotional and cognitive disorders, that increases the incidence of serious complications and worsens the treatment outcome and life quality in weakened oncological patients. Multimodal pre-rehabilitation before surgery can significantly decrease the incidence and severity of postoperative complications...
2024: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
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JOURNAL ARTICLE
Pere Verdugo, David Santiago, Silvia De la Flor, Àngels Serra
This study presents the synthesis of a novel biobased epoxy monomer derived from vanillin and cystamine, incorporating imine and disulfide exchangeable groups within its structure. A series of epoxy-based vitrimers with two simultaneous exchange relaxation processes have been produced using this monomer. These exchange mechanisms operate without the need for any catalyst. Four different amine curing agents have been employed to achieve vitrimers with glass transition temperatures around 100 °C and excellent thermal stability...
April 15, 2024: ACS Sustainable Chemistry & Engineering
#6
JOURNAL ARTICLE
Nour Younis, Núria Puigmal, Abdallah El Kurdi, Andrew Badaoui, Dongliang Zhang, Claudia Morales, Anis Saad, Diane Cruz, Nadim Al Rahy, Andrea Daccache, Triana Huerta, Christa Deban, Ahmad Halawi, John Choi, Pere Dosta, Christine Lian, Natalie Artzi, Jamil R Azzi
Disorders in the regulatory arm of the adaptive immune system result in autoimmune-mediated diseases. While systemic immunosuppression is the prevailing approach to manage them, it fails to achieve long-lasting remission due to concomitant suppression of the regulatory arm and carries the risk of heightened susceptibility to infections and malignancies. Alopecia Areata is a condition characterized by localized hair loss due to autoimmunity. The accessibility of the skin provides an opportunity for local rather than systemic intervention to avoid broad immunosuppression...
April 18, 2024: Advanced Materials
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JOURNAL ARTICLE
Sefora Conti, Valeria Venturini, Adrià Cañellas-Socias, Carme Cortina, Juan F Abenza, Camille Stephan-Otto Attolini, Emily Middendorp Guerra, Catherine K Xu, Jia Hui Li, Leone Rossetti, Giorgio Stassi, Pere Roca-Cusachs, Alba Diz-Muñoz, Verena Ruprecht, Jochen Guck, Eduard Batlle, Anna Labernadie, Xavier Trepat
Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how these properties might contribute to metastasis is poorly understood. Using CRC patient derived organoids (PDOs), we find that compared to LGR5- cells, LGR5+ cancer stem cells are stiffer, adhere better to the extracellular matrix (ECM), move slower both as single cells and clusters, display higher nuclear YAP, show a higher survival rate in response to mechanical confinement, and form larger transendothelial gaps...
April 18, 2024: Nature Communications
#8
JOURNAL ARTICLE
Gabriel Khattar, Pedro R Peres-Neto
AbstractThe nonrandom association between landscape characteristics and the dominant life history strategies observed in species pools is a typical pattern in nature. Here, we argue that these associations determine predictable changes in the relative importance of assembly mechanisms along broadscale geographic gradients (i.e., the geographic context of metacommunity dynamics). To demonstrate that, we employed simulation models in which groups of species with the same initial distribution of niche breadths and dispersal abilities interacted across a wide range of landscapes with contrasting characteristics...
May 2024: American Naturalist
#9
JOURNAL ARTICLE
Sebastiana Arroyo-Bote, Catalina Bennasar-Verger, Andrés Martínez-Jover, Pablo Ferragut-Pina, Pere Riutot-Sbert, Ángel Arturo López-González, Pål Barkvol
INTRODUCTION: The acquisition of skills and manual dexterity in aesthetic dentistry in undergraduate teaching requires preclinical practices with simulation that should approximate real clinical situations. OBJECTIVE: We will present a digital procedure for the creation of three-dimensional (3D) resin models adapted to the practices of the Aesthetic Dentistry course. MATERIAL AND METHOD: Stereolithography or Standard Tesellation Language (STL) files of a real patient were previously obtained with a 3-shape intraoral scanner...
April 18, 2024: Journal of Dental Education
#10
JOURNAL ARTICLE
Guillem Navarra-Ventura, Pau Riera-Serra, Miquel Roca, Margalida Gili, Mauro García-Toro, Gemma Vilagut, Itxaso Alayo, Laura Ballester, Maria Jesús Blasco, Pere Castellví, Joan Colom, Cristina Casajuana, Andrea Gabilondo, Carolina Lagares, José Almenara, Andrea Miranda-Mendizabal, Philippe Mortier, José Antonio Piqueras, Victoria Soto-Sanz, Jordi Alonso
BACKGROUND: Previous studies conducted in various nationally representative samples of the general population show that positive mental health is related to social prosperity. However, specific studies in university populations are scarce. In this study, we set out to explore factors associated with mental well-being (MWB) in a representative sample of first-year university students in Spain. METHODS: MWB was assessed with the short version of the Warwick-Edinburgh Mental Well-Being Scale...
April 15, 2024: Journal of Affective Disorders
#11
JOURNAL ARTICLE
Nadeen Abujaber, Meg Ryan, Kelly A McBride, Pia Tingsted Blum, Michelle Engels, Anna Didenko, Hannah Green, Catia Sofia Peres de Matos, Shona Whitton, Frédérique Vallières
Mental Health and Psychosocial Support (MHPSS) practitioners working in humanitarian contexts are at significant risk of mental health conditions, ultimately hindering the quality and sustainability of their work. Supportive supervision has shown to be effective in improving the wellbeing of MHPSS staff and volunteers and enhancing the effectiveness of MHPSS service delivery. Despite these proven benefits, there is a lack of standardised guidelines to inform supportive supervision within humanitarian contexts...
2024: PLOS Glob Public Health
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JOURNAL ARTICLE
Leandro T Anselmo, Thalisson A de Souza, Thiago A M Brito, Eldrinei G Peres, Felipe M A da Silva, Valdenizia R Silva, Luciano de S Santos, Milena B P Soares, Daniel P Bezerra, Emmanoel V Costa, Victor M Sipoloni, Lívia S de Medeiros, Marcelo S da Silva, Josean F Tavares, Waldireny R Gomes, Hector H F Koolen
Two unusual naphthoquinones, named here as pleonotoquinones A ( 1 ) and B ( 2 ), were isolated along with two known anthraquinones ( 3 and 4 ) via chromatographic separations of an ethyl acetate extract of the roots of Pleonotoma jasminifolia . Compounds 1 and 2 are the first examples of quinones bearing a 2-methyloxepine moiety. The compounds were isolated with the aid of mass spectrometry and molecular networking, and their structures were resolved using 1D and 2D NMR and HRESIMS data. The isolated compounds were evaluated for their antiproliferative activity against human cancer cell lines, and compounds 1 and 2 displayed cytotoxicity against human colon cancer HCT116 cells (IC50 = 2...
April 17, 2024: Journal of Natural Products
#13
JOURNAL ARTICLE
María S Landa, Mariano L Schuman, Maia Aisicovich, Ludmila S Peres Diaz, Mariela M Gironacci, Silvia I García, Carlos J Pirola
UNLABELLED: Central TRH, a neuropeptide, is involved in cardiovascular regulation. We demonstrated that the overexpression of diencephalic TRH (dTRH) in SHR rats can be prevented by antisense treatment, normalizing blood pressure (BP). Valproate (VPA) is an inhibitor of histone deacetylases (HDAC) which modulates gene expression through epigenetic modifications such as DNA methylation. AIMS: Study the role of HDAC inhibition in the regulation of dTRH gene expression and its effect on the pathogenesis of hypertension...
April 17, 2024: Molecular and Cellular Biochemistry
#14
JOURNAL ARTICLE
Rafael Peres da Silva, Chayaporn Suphavilai, Niranjan Nagarajan
BACKGROUND: With the rapid increase in throughput of long-read sequencing technologies, recent studies have explored their potential for taxonomic classification by using alignment-based approaches to reduce the impact of higher sequencing error rates. While alignment-based methods are generally slower, k-mer-based taxonomic classifiers can overcome this limitation, potentially at the expense of lower sensitivity for strains and species that are not in the database. RESULTS: We present MetageNN, a memory-efficient long-read taxonomic classifier that is robust to sequencing errors and missing genomes...
April 16, 2024: BMC Bioinformatics
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JOURNAL ARTICLE
Lisa Graille-Avy, Clemence Boutiere, Camille Rigollet, Marine Perriguey, Audrey Rico, Sarah Demortiere, Pierre Durozard, Frederic Hilezian, Frederic Vely, Pierre Bertault-Peres, Jean Pelletier, Adil Maarouf, Bertrand Audoin
BACKGROUND AND OBJECTIVES: Real-life studies noted that the risk of disease activity in multiple sclerosis (MS) after switching to rituximab (RTX) or ocrelizumab (OCR) may be unequal depending on prior disease-modifying therapy (DMT), with a higher risk associated with fingolimod (FING). METHODS: We performed a retrospective analysis of a structured prospective data collection including all consecutive patients with relapsing MS who were prescribed RTX/OCR in the MS center of Marseille...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
#16
JOURNAL ARTICLE
Jose R Franco, Gerardo Priotto, Massimo Paone, Giuliano Cecchi, Agustin Kadima Ebeja, Pere P Simarro, Dieudonne Sankara, Samia B A Metwally, Daniel Dagne Argaw
BACKGROUND: Human African trypanosomiasis (HAT) is a neglected tropical disease that usually occurs in rural areas in sub-Saharan Africa. It caused devastating epidemics during the 20th century. Sustained, coordinated efforts by different stakeholders working with national sleeping sickness control programmes (NSSCPs) succeeded in controlling the disease and reducing the number of cases to historically low levels. In 2012, WHO targeted the elimination of the disease as a public health problem by 2020...
April 16, 2024: PLoS Neglected Tropical Diseases
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JOURNAL ARTICLE
Raquel Prat, Anna Puig-Ribera, Mireia Pagerols, Gemma Español-Martín, Cristina Rivas, Aurea Autet, Pere Tàpies, Ana C Martín, Miquel Casas, Rosa Bosch
OBJECTIVES: To describe the daily Physical Activity (PA) patterns of adolescents with Attention-deficit/hyperactivity disorder (ADHD), to analyze the differences in terms of PA patterns between adolescents with ADHD and those without ADHD, and to study the factors associated with achieving the daily PA recommendations. METHODS: The sample was composed of 778 adolescents who provided complete information on their PA patterns through the Physical Activity Questionnaire for Adolescents (PAQ-A)...
April 15, 2024: Journal of Attention Disorders
#18
JOURNAL ARTICLE
Jinxia Liu, Jane MacNaughtan, Annarein J C Kerbert, Theo Portlock, Javier Martínez Gonzalez, Yi Jin, Frederick Clasen, Abeba Habtesion, Huoyan Ji, Qin Jin, Alexandra Phillips, Francesco De Chiara, Ganesh Ingavle, Cesar Jimenez, Giacomo Zaccherini, Katherine Husi, Miguel Angel Rodriguez Gandia, Paul Cordero, Junpei Soeda, Lynda McConaghy, Jude Oben, Karen Church, Jia V Li, Haifeng Wu, Aarti Jalan, Pere Gines, Elsa Solà, Simon Eaton, Carrie Morgan, Michal Kowalski, Daniel Green, Amir Gander, Lindsey A Edwards, I Jane Cox, Helena Cortez-Pinto, Thomas Avery, Reiner Wiest, Francois Durand, Paolo Caraceni, Roberto Elosua, Joan Vila, Marco Pavesi, Vicente Arroyo, Nathan Davies, Rajeshwar P Mookerjee, Victor Vargas, Susan Sandeman, Gautam Mehta, Saeed Shoaie, Julian Marchesi, Agustín Albillos, Fausto Andreola, Rajiv Jalan
OBJECTIVE: Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in models of cirrhosis and acute-on-chronic liver failure (ACLF) and, its safety and tolerability in a clinical trial in cirrhosis. DESIGN: Performance of Yaq-001 was evaluated in vitro . Two-rat models of cirrhosis and ACLF, (4 weeks, bile duct ligation with or without lipopolysaccharide), receiving Yaq-001 for 2 weeks; and two-mouse models of cirrhosis (6-week and 12-week carbon tetrachloride (CCl4)) receiving Yaq-001 for 6 weeks were studied...
April 15, 2024: Gut
#19
JOURNAL ARTICLE
Nicolau Guanyabens, Noemí Tomsen, Ernest Palomeras, Lluís Mundet, Pere Clavé, Omar Ortega
OBJECTIVE: To characterize swallowing biomechanics and neurophysiology in older patients with oropharyngeal dysphagia (OD). METHODS: Observational study in 12 young healthy volunteers (HV), 9 older HV (OHV) and 12 older patients with OD with no previous diseases causing OD (OOD). Swallowing biomechanics were measured by videofluoroscopy, neurophysiology with pharyngeal sensory (pSEP) and motor evoked-potentials (pMEP) to intrapharyngeal electrical and transcranial magnetic stimulation (TMS), respectively, and salivary neuropeptides with enzyme-linked immunosorbent assay (ELISA)...
April 4, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
#20
JOURNAL ARTICLE
Enio A M Santos, Tatiana A Zaccara, Cristiane F Paganoti, Stela V Peres, Rossana P V Francisco, Rafaela A Costa
AIMS: To evaluate the association between extrapolated time in range (eTIR), measured by self-monitoring of blood glucose (SMBG), and large-for-gestational-age (LGA) infants in pregnancies with type 1 diabetes (T1D). METHODS: Retrospective cohort analysis including singleton pregnancies with T1D who started antenatal care before 20 gestational weeks and delivered live newborns at a Brazilian hospital between 2010 and 2019, with LGA fetuses as the main outcome. Glycemic records acquired using SMBG were categorized as eTIR, extrapolated time below range (eTBR), and extrapolated time above range (eTAR)...
March 19, 2024: Journal of Diabetes and its Complications
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