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https://www.readbyqxmd.com/read/28329104/vascular-cerebral-damage-in-frail-older-adults-the-amimage-study
#1
José Alberto Avila-Funes, Amandine Pelletier, Céline Meillon, Gwénaëlle Catheline, Olivier Periot, Irene Trevin O-Frenk, Magali Gonzalez-Colaço, Jean-François Dartigues, Karine Pérès, Michèle Allard, Bixente Dilharreguy, Hélène Amieva
Background: Frailty has been associated with increased risk of adverse-health related outcomes including cognitive impairment. However, little is know about the pathogenesis relating frailty to cognitive decline. Therefore, the main objective of this study was to investigate the association between vascular cerebral damage and frailty. Methods: Cross-sectional study involving 176 community-dwelling participants aged 67-86 years, participating in the AMImage Study, an ancillary neuro-imaging project of the AMI cohort, a French prospective cohort including older farmers living in rural areas...
January 21, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28324317/anxiety-and-depression-symptoms-and-migraine-a-symptom-based-approach-research
#2
Mario Fernando Prieto Peres, Juliane P P Mercante, Patricia R Tobo, Helder Kamei, Marcelo Eduardo Bigal
BACKGROUND: Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited information is available on how specific anxiety and depression symptoms are related to migraine. Symptoms-based approach, a current trend in mental health research, may improve our understanding in migraine comorbidity. The purpose of this study was to analyze how anxiety and depression aspects are related to migraine through a symptom-based approach...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28320166/the-duration-of-the-cortical-silent-period-is-not-abnormal-in-restless-legs-syndrome-willis-ekbom-disease
#3
Joselisa Péres Queiroz de Paiva, Samir Câmara Magalhães, Gilmar Fernandes do Prado, Alan Luiz Eckeli, Alain Kaelin-Lang, Adriana Bastos Conforto
OBJECTIVE: To compare the duration of the cortical silent period (CSP) measured in a hand muscle in subjects with primary Restless Legs Syndrome (RLS/WED) and controls, using four different methods of analysis. METHODS: The CSP to transcranial magnetic stimulation of the dominant motor cortex was assessed in the abductor digiti minimi of 33 subjects with RLS/WED and 24 controls. CSP duration was measured by an automated and three visually-guided methods. RESULTS: There were significant differences between absolute values of CSP duration according to the method of analysis...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28318984/safety-and-efficacy-of-thrombectomy-in-acute-ischaemic-stroke-revascat-1-year-follow-up-of-a-randomised-open-label-trial
#4
Antoni Dávalos, Erik Cobo, Carlos A Molina, Angel Chamorro, M Angeles de Miquel, Luis San Román, Joaquín Serena, Elena López-Cancio, Marc Ribó, Mónica Millán, Xabier Urra, Pere Cardona, Alejandro Tomasello, Carlos Castaño, Jordi Blasco, Lucía Aja, Marta Rubiera, Meritxell Gomis, Arturo Renú, Blanca Lara, Joan Martí-Fàbregas, Brian Jankowitz, Neus Cerdà, Tudor G Jovin
BACKGROUND: The REVASCAT trial and other studies have shown that the neurovascular thrombectomy improves outcomes at 90 days post stroke. However, whether the observed benefit is sustained in the long term remains unknown. We report the results of the prespecified 12-month analysis of the REVASCAT trial. METHODS: Patients with acute ischaemic stroke who could be treated within 8 h of symptom onset were randomly assigned to medical therapy (including intravenous alteplase when eligible) and neurovascular thrombectomy with Solitaire FR or medical therapy alone...
March 16, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28318771/cross-protection-to-new-drifted-influenza-a-h3-viruses-and-prevalence-of-protective-antibodies-to-seasonal-influenza-during-2014-in-portugal
#5
Raquel Guiomar, Susana Pereira da Silva, Patrícia Conde, Paula Cristóvão, Ana Carina Maia, Pedro Pechirra, Ana Paula Rodrigues, Baltazar Nunes, Luís Milho, Ana Paula Coelho, Aida Fernandes, Paula Caseiro, Fernando Rodrigues, Lurdes Correia, João Pereira-Vaz, Sofia Almeida, Paula Branquinho, Rita Côrte-Real, Regina Viseu, Maria João Peres, Raquel Sanches, Filipa Dantas, Ludovina Freitas, Graça Andrade, Manuel Maurílio, Filomena Caldeira, Rita Cabral Veloso, Luisa Mota-Vieira, Marta Soares, Ana Rita Couto, Jácome Bruges-Armas, Rita Mouro Pinto, Joana Sobrinho Simões, Maria do Rosário Costa, João Tiago Guimarães, Luís Martins, Mário Cunha
INTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. MATERIALS AND METHODS: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal...
March 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28318147/effects-of-alfapump-system-on-kidney-and-circulatory-function-in-patients-with-cirrhosis-and-refractory-ascites
#6
Elsa Solà, Santiago Sanchez-Cabús, Ezequiel Rodriguez, Chiara Elia, Raquel Cela, Rebeca Moreira, Elisa Pose, Jordi Sánchez-Delgado, Nuria Cañete, Manuel Morales-Ruiz, Francisco Campos, Jaume Balust, Mónica Guevara, Juan Carlos García-Valdecasas, Pere Ginès
The alfapump system has been proposed as a new treatment for the management of refractory ascites. The system removes ascites from the peritoneal cavity to urinary bladder, producing a continuous low-volume paracentesis. AIM: To investigate the effects of treatment with the alfapump system on kidney and circulatory function in patients with cirrhosis and refractory ascites. METHODS: Prospective study including 10 patients with cirrhosis and refractory ascites. Primary outcomes were changes in glomerular filtration rate (GFR), as assessed by isotopic techniques, and changes in circulatory function assessed by arterial pressure, cardiac output and activity of vasoconstrictor systems...
March 20, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28316775/guarana-paullinia-cupana-mart-attenuates-methylmercury-induced-toxicity-in-caenorhabditis-elegans
#7
Leticia Priscilla Arantes, Tanara Vieira Peres, Pam Chen, Samuel Caito, Michael Aschner, Félix Alexandre Antunes Soares
The influence of routine guarana (Paullinia cupana) consumption on apparent tolerance to mercury intoxication has been proposed. The present study investigated this hypothesis in Caenorhabditis elegans, a suitable experimental model for studies in toxicology. Wild type (WT) and skn-1 (ok2315) worm strains were pretreated with guarana ethanolic extract (GEE) from larvae 1 (L1) to L4 stage and then exposed for 6 hours to methylmercury (MeHg). The analyses included evaluation of GEE's effects on lethality, developmental delay, feeding, locomotion, gene expression (sod-3, gst-4, sir-2...
November 1, 2016: Toxicology Research
https://www.readbyqxmd.com/read/28316542/analysing-the-costs-of-integrated-care-a-case-on-model-selection-for-chronic-care-purposes
#8
Marc Carreras, Inma Sánchez-Pérez, Pere Ibern, Jordi Coderch, José María Inoriza
BACKGROUND: The objective of this study is to investigate whether the algorithm proposed by Manning and Mullahy, a consolidated health economics procedure, can also be used to estimate individual costs for different groups of healthcare services in the context of integrated care. METHODS: A cross-sectional study focused on the population of the Baix Empordà (Catalonia-Spain) for the year 2012 (N = 92,498 individuals). A set of individual cost models as a function of sex, age and morbidity burden were adjusted and individual healthcare costs were calculated using a retrospective full-costing system...
August 19, 2016: International Journal of Integrated Care
https://www.readbyqxmd.com/read/28304213/characterization-of-the-genetic-environment-of-the-blaveb-4-gene-associated-with-a-transposable-region-in-a-proteus-mirabilis-clinical-isolate
#9
Paula Espinal, Elisenda Miró, Laia Ramoneda, Manel Flores, Alba Rivera, Pere Coll, Ferran Navarro
Proteus mirabilis is the second most common cause of urinary tract infections and is also an important cause of nosocomial infections. TEM-type and CTX-M-type extended-spectrum β-lactamases (ESBLs) are the most widely distributed in this bacterial species, but minor ESBLs such as the VEB-type have also been identified. The aim of this study was to analyze the genetic environment of the blaVEB-4 gene found in a P. mirabilis clinical isolate recovered in Spain. P. mirabilis N2231 showed resistance to penicillins, cephalosporins, and aminoglycosides, remaining susceptible to imipenem, cefoxitin, β-lactamases inhibitors, and quinolones...
March 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28298730/mapping-the-different-methods-adopted-for-diagnostic-imaging-instruction-at-medical-schools-in-brazil
#10
Rubens Chojniak, Dominique Piacenti Carneiro, Gustavo Simonetto Peres Moterani, Ivone da Silva Duarte, Almir Galvão Vieira Bitencourt, Valdair Francisco Muglia, Giuseppe D'Ippolito
OBJECTIVE: To map the different methods for diagnostic imaging instruction at medical schools in Brazil. MATERIALS AND METHODS: In this cross-sectional study, a questionnaire was sent to each of the coordinators of 178 Brazilian medical schools. The following characteristics were assessed: teaching model; total course hours; infrastructure; numbers of students and professionals involved; themes addressed; diagnostic imaging modalities covered; and education policies related to diagnostic imaging...
January 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28296386/direct-drawing-method-of-graphite-onto-paper-for-high-performance-flexible-electrochemical-sensors
#11
Murilo Santhiago, Mathias Strauss, Mariane P Pereira, Andréia S Chagas, Carlos C B Bufon
A simple and fast fabrication method to create high-performance pencil-drawn electrochemical sensors is reported for the first time. The sluggish electron transfer observed on bare pencil-drawn surfaces was enhanced using two electrochemical steps: first oxidizing the surface and then reducing it in a subsequent step. The heterogeneous rate constant was found to be 5.1 × 10(-3) cm s(-1), which is the highest value reported so far for pencil-drawn surfaces. We mapped the origin of such performance by atomic force microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28283920/impact-of-bariatric-surgery-on-heme-oxygenase-1-inflammation-and-insulin-resistance-in-morbid-obesity-with-obstructive-sleep-apnea
#12
Raquel Tirado, Maria José Masdeu, Laura Vigil, Mercedes Rigla, Alexis Luna, Pere Rebasa, Rocío Pareja, Marta Hurtado, Assumpta Caixàs
INTRODUCTION: Morbid obesity and obstructive sleep apnea (OSA) interact at an inflammatory level. Bariatric surgery reduces inflammatory responses associated with obesity. Heme oxygenase-1 (HO-1) is an enzyme with anti-inflammatory properties, which might be increased in morbid obesity or OSA. We studied morbidly obese patients with OSA to determine: (a) HO-1 plasma concentrations according to OSA severity and their relationship with insulin resistance and inflammation and (b) the impact of bariatric surgery on HO-1 and parameters of insulin resistance and inflammation...
March 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28283681/gene-expression-analyses-in-tomato-near-isogenic-lines-provide-evidence-for-ethylene-and-abscisic-acid-biosynthesis-fine-tuning-during-arbuscular-mycorrhiza-development
#13
Giselle Gomes Monteiro Fracetto, Lázaro Eustáquio Pereira Peres, Marcio Rodrigues Lambais
Plant responses to the environment and microorganisms, including arbuscular mycorrhizal fungi, involve complex hormonal interactions. It is known that abscisic acid (ABA) and ethylene may be involved in the regulation of arbuscular mycorrhiza (AM) and that part of the detrimental effects of ABA deficiency in plants is due to ethylene overproduction. In this study, we aimed to determine whether the low susceptibility to mycorrhizal colonization in ABA-deficient mutants is due to high levels of ethylene and whether AM development is associated with changes in the steady-state levels of transcripts of genes involved in the biosynthesis of ethylene and ABA...
March 11, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28274646/general-characteristics-and-activity-of-emergency-department-short-stay-units-in-spanish-hospitals
#14
Carles Ferré, Ferran Llopis, Francisco Javier Martín-Sánchez, Gonzalo Sempere, Pere Llorens, Carmen Navarro, Mikel Martínez-Ortiz, Antoni Juan
BACKGROUND: Emergency Department (ED) overcrowding mainly due to the lack of access to inpatient beds negatively affects safety and quality of care. Implementation of ED short-stay units (EDSSUs) may help to mitigate this situation. OBJECTIVES: To describe the general characteristics and evaluate the activity of EDSSUs in Spanish hospitals. METHODS: This is a cross-sectional study. A questionnaire was sent to coordinators responsible for the EDSSUs identified among Spanish hospitals appearing on the Ministry of Health Web page...
March 5, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28274618/what-factors-drive-inpatient-satisfaction-after-knee-arthroplasty
#15
Ashwin Peres-da-Silva, Lindsay T Kleeman, Samuel S Wellman, Cynthia L Green, David E Attarian, Michael P Bolognesi, Thorsten M Seyler
BACKGROUND: The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, developed by the Centers for Medicare & Medicaid Services, is directly tied to hospital reimbursement. The purpose of this study is to analyze survey responses from patients who underwent primary knee arthroplasty in order to identify factors that drive patient dissatisfaction in the inpatient setting. METHODS: HCAHPS responses received from patients undergoing elective total and unicompartmental knee arthroplasty at our institution between January 1, 2013 and January 1, 2016 were obtained and expressed as a percentage of overall satisfaction...
February 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28273561/ferrocene-embedded-flavonoids-targeting-the-achilles-heel-of-multidrug-resistant-cancer-cells-through-collateral-sensitivity
#16
Basile Pérès, Rachad Nasr, Malik Zarioh, Florine Lecerf-Schmidt, Attilio Di Pietro, Hélène Baubichon-Cortay, Ahcène Boumendjel
With the aim to develop anticancer agents acting selectively against resistant tumor cells, we investigated ferrocene embedded into chalcone, aurone and flavone skeletons. These compounds were conceived and then investigated based on the concept of collateral sensitivity, where the target is the Achilles Heel of cancer cells overexpressing the multidrug ABC transporter MRP1. The 14 synthesized compounds were evaluated for their ability to induce efflux of glutathione (GSH) from tumor cells overexpressing MRP1...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28273214/integrated-predictive-model-for-prostatic-cancer-using-clinical-laboratory-and-ultrasound-data
#17
Gustavo David Ludwig, Henrique Peres Rocha, Lúcio José Botelho, Maiara Brusco Freitas
OBJECTIVE: to develop a predictive model to estimate the probability of prostate cancer prior to biopsy. METHODS: from September 2009 to January 2014, 445 men underwent prostate biopsy in a radiology service. We excluded from the study patients with diseases that could compromise the data analysis, who had undergone prostatic resection or used 5-alpha-reductase inhibitors. Thus, we selected 412 patients. Variables included in the model were age, prostate specific antigen (PSA), digital rectal examination, prostate volume and abnormal sonographic findings...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28273067/aboriginal-mitogenomes-reveal-50-000-years-of-regionalism-in-australia
#18
Ray Tobler, Adam Rohrlach, Julien Soubrier, Pere Bover, Bastien Llamas, Jonathan Tuke, Nigel Bean, Ali Abdullah-Highfold, Shane Agius, Amy O'Donoghue, Isabel O'Loughlin, Peter Sutton, Fran Zilio, Keryn Walshe, Alan N Williams, Chris S M Turney, Matthew Williams, Stephen M Richards, Robert J Mitchell, Emma Kowal, John R Stephen, Lesley Williams, Wolfgang Haak, Alan Cooper
Aboriginal Australians represent one of the longest continuous cultural complexes known. Archaeological evidence indicates that Australia and New Guinea were initially settled approximately 50 thousand years ago (ka); however, little is known about the processes underlying the enormous linguistic and phenotypic diversity within Australia. Here we report 111 mitochondrial genomes (mitogenomes) from historical Aboriginal Australian hair samples, whose origins enable us to reconstruct Australian phylogeographic history before European settlement...
March 8, 2017: Nature
https://www.readbyqxmd.com/read/28270195/lapachol-a-compound-targeting-pyrimidine-metabolism-ameliorates-experimental-autoimmune-arthritis
#19
Raphael S Peres, Gabriela B Santos, Nerry T Cecilio, Valquíria A P Jabor, Michael Niehues, Bruna G S Torres, Gabriela Buqui, Carlos H T P Silva, Teresa Dalla Costa, Norberto P Lopes, Maria C Nonato, Fernando S Ramalho, Paulo Louzada-Júnior, Thiago M Cunha, Fernando Q Cunha, Flavio S Emery, Jose C Alves-Filho
BACKGROUND: The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. However, a considerable proportion of RA patients are refractory to LEF. Here, we investigated lapachol (LAP), a natural naphthoquinone, as a potential DHODH inhibitor and addressed its immunosuppressive properties. METHODS: Molecular flexible docking studies and bioactivity assays were performed to determine the ability of LAP to interact and inhibit DHODH...
March 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28269717/assessment-of-sedation-analgesia-by-means-of-poincare%C3%AC-analysis-of-the-electroencephalogram
#20
Jose D Bolanos, Montserrat Vallverdu, Pere Caminal, Daniel F Valencia, Xavi Borrat, Pedro L Gambus, Jose F Valencia
Monitoring the levels of sedation-analgesia may be helpful for managing patient stress on minimally invasive medical procedures. Monitors based on EEG analysis and designed to assess general anesthesia cannot distinguish reliably between a light and deep sedation. In this work, the Poincaré plot is used as a nonlinear technique applied to EEG signals in order to characterize the levels of sedation-analgesia, according to observed categorical responses that were evaluated by means of Ramsay Sedation Scale (RSS)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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