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https://www.readbyqxmd.com/read/29778416/the-use-of-the-shock-index-as-a-predictor-of-active-bleeding-in-trauma-patients
#1
Andrea Campos-Serra, Sandra Montmany-Vioque, Pere Rebasa-Cladera, Heura Llaquet-Bayo, Raquel Gràcia-Roman, Anna Colom-Gordillo, Salvador Navarro-Soto
INTRODUCTION: Vital signs indicate the presence of bleeding only after large amounts of blood have been lost, with high morbidity and mortality. The Shock Index (SI) is a hemorrhage indicator with a cut-off point for the risk of bleeding at 0.9. The aim of this study is to assess whether a cut-off of≥0.8 is more sensitive for detecting occult bleeding, providing for early initiation of therapeutic maneuvers. METHODS: SI analytical validation study of severe trauma patients older than 16 years of age...
May 16, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29775738/humoral-and-mucosal-immune-responses-in-meagre-argyrosomus-regius-juveniles-fed-diets-with-varying-inclusion-levels-of-carob-seed-germ-meal
#2
Francisco Antonio Guardiola, Carolina Barroso, Paula Enes, Ana Couto, Patricia Díaz-Rosales, António Afonso, Erika Kanashiro, Helena Peres, Elisabete Matos, Aires Oliva-Teles, Pedro Pousão-Ferreira, Benjamín Costas
Many studies have assessed the effects of incorporation of plant feedstuffs in fish diets on growth performance, whereas few studies have addressed the effects of fish meal replacement by plant protein sources on fish immune parameters. Thus, the aim of this study was to evaluate the effects on immune response of different inclusion levels of carob seed germ meal (CSGM) as partial replacement for fish meal in diets for meagre (Argyrosomus regius) juveniles. Fish were fed four experimental diets with increased CSGM inclusion levels [0% (control), 7...
May 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29765398/epidemiology-of-intracranial-hemorrhage-associated-with-oral-anticoagulants-in-spain-trends-in-anticoagulation-complications-registry-the-tac-2-study
#3
Gustavo Zapata-Wainberg, Sonia Quintas, Álvaro Ximénez-Carrillo Rico, Jaime Masjuán Vallejo, Pere Cardona, Mar Castellanos Rodrigo, Lorena Benavente Fernández, Andrés García Pastor, José Egido, José Maciñeiras, Joaquín Serena, María Del Mar Freijo Guerrero, Francisco Moniche, José Vivancos
Objective: Patients receiving treatment with oral anticoagulants (OACs) are at risk of intracranial hemorrhage (ICH). In this study, we describe the epidemiological and clinical characteristics of patients receiving OACs who experience ICH and compare those receiving vitamin K antagonists (ICH-VKAs) with those receiving direct OACs (ICH-DOACs). Methods: We performed a national, multicenter, descriptive, observational, retrospective study of all adult patients receiving OACs who were admitted to the neurology department with ICH over a 1-year period...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29765172/dietary-sucrose-regulates-the-expression-of-the-cd36-gene-in-hepatic-tissue-of-rats-with-obesity-and-non-alcoholic-fatty-liver-disease-nafld
#4
Rodolfo Quintana Castro, Ida Soto Rodriguez, Rosa A Deschamps Lago, Peter Grube Pagola, Jorge Rodriguez Antolin, Adriana Peres Quintal, Jaime Rivera Rivera, Alfonso Alexander Aguilera
AIM: To evaluate the mRNA expression levels of Cd36 in adipose and hepatic tissues, in rats with NAFLD after the consumption of sucrose for 10 and 20 weeks. METHODS: Twenty Wistar rats, all nearly 21 days old were divided into two experimental groups (NAFLD-10 and NAFLD-20), that received a standard diet (2014 Teklad Global) plus 30% sucrose in their drinking water for 10 and 20 weeks and the control groups (C Groups). Variables such as body weight, food intakes, and serum parameters were measured...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29762728/atypical-myopathy-in-p%C3%A3-re-david-s-deer-elaphurus-davidianus-associated-with-ingestion-of-hypoglycin-a
#5
C Bunert, S Langer, D M Votion, F Boemer, A Müller, K Ternes, A Liesegang
From 2004 until 2016, 21 Père David's deer (Elaphurus davidianus) have died for unknown reason at Zoo Duisburg. These deer, also known as milu, have succumbed from a myopathy that occurred seasonally in autumn and in spring. The clinical signs shown by the animals, closely resembles those of a disease called equine atypical myopathy (EAM), which is formerly known in horses. The cause for EAM in Europe was found in the ingestion of hypoglycin A, contained in samaras and seedlings of the sycamore maple tree (Acer pseudoplatanus)...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29762694/comparative-study-of-postmortem-concentrations-of-antidepressants-in-several-different-matrices
#6
Åse Marit Leere Øiestad, Ritva Karinen, Sidsel Rogde, Stian Nilsen, Kari-Beate Boye Eldor, Gerd-Wenche Brochmann, Marianne Arnestad, Elisabeth Leere Øiestad, Mariana Dadalto Peres, Lena Kristoffersen, Vigdis Vindenes
Peripheral blood (PB) is considered to be the golden standard for measuring postmortem drug concentrations. In several cases, PB is however not available, but information regarding drug findings might still be crucial in order to determine the cause of death. Antidepressants are frequently detected in postmortem samples from forensic toxicology cases, but the literature investigating concentrations in other matrices than peripheral and heart blood is limited.We here describe a study for comparison of concentrations for a large number of different drugs in six different matrices...
May 14, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29761934/assessing-the-heterogeneity-of-autism-spectrum-symptoms-in-a-school-population
#7
Paula Morales-Hidalgo, Pere J Ferrando, Josefa Canals
The aim of the present study was to assess whether the nature of the main autistic features (i.e., social communication problems and repetitive and restrictive patterns) are better conceptualized as dimensional or categorical in a school population. The study was based on the teacher ratings of two different age groups: 2,585 children between the ages of 10 and 12 (Primary Education; PE) and 2,502 children between the ages of 3 and 5 (Nursery Education; NE) from 60 mainstream schools. The analyses were based on Factor Mixture Analysis, a novel approach that combines dimensional and categorical features and prevents spurious latent classes from appearing...
May 15, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29761340/reduction-of-direct-health-costs-associated-with-pertussis-vaccination-with-acellular-vaccines-in-children-aged-0-9-years-with-pertussis-in-catalonia-spain
#8
Pedro Plans-Rubió, Encarna Navas, Pere Godoy, Gloria Carmona, Angela Domínguez, Mireia Jané, Carmen Muñoz-Almagro, Pedro Brotons
OBJECTIVES: The aim of this study was to assess direct health costs in children with pertussis aged 0-9 years who were vaccinated, partially vaccinated, and unvaccinated during childhood, and to assess the association between pertussis costs and pertussis vaccination in Catalonia (Spain) in 2012-2013. METHODS: Direct healthcare costs included pertussis treatment, pertussis detection, and preventive chemotherapy of contacts. Pertussis patients were considered vaccinated when they had received 4-5 doses, and unvaccinated or partially vaccinated when they had received 0-3 doses of vaccine...
May 14, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29755326/transient-hypothyroidism-during-lactation-arrests-myelination-in-the-anterior-commissure-of-rats-a-magnetic-resonance-image-and-electron-microscope-study
#9
Federico S Lucia, Jesús Pacheco-Torres, Susana González-Granero, Santiago Canals, María-Jesús Obregón, José M García-Verdugo, Pere Berbel
Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29753644/extradural-anterior-clinoidectomy-in-the-management-of-parasellar-meningiomas-analysis-of-13-years-of-experience-and-literature-review
#10
Laura Salgado López, Fernando Muñoz Hernández, Carlos Asencio Cortés, Pere Tresserras Ribó, María Jesús Álvarez Holzapfel, Joan Molet Teixidó
BACKGROUND AND AIM: The extradural anterior clinoidectomy (EAC) is a key microsurgical technique that facilitates the resection of tumors located in the parasellar region. There is currently no consensus regarding the execution of the procedure via extradural or intradural nor scientific evidence that supports its routine use. The purpose of this article is to expose our experience in performing EAC as part of the management of the parasellar meningiomas. MATERIALS AND METHODS: A retrospective analysis of the EAC for parasellar meningioma resection performed in our center between 2003 and 2015 was done...
May 9, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29752864/%C3%AE-blockers-interfere-with-cell-homing-receptors-and-regulatory-proteins-in-a-model-of-spontaneously-hypertensive-rats
#11
Bruna Eibel, Melissa Kristochek, Thiago R Peres, Lucinara D Dias, Daniela R Dartora, Karina R Casali, Renato A K Kalil, Alexandre M Lehnen, Maria Claudia Irigoyen, Melissa M Markoski
AIM: To examine the interference of β-blockers with the chemokine stromal cell-derived factor-1 (SDF-1) found in cell homing receptors, C-X-C chemokine receptor type 4 (CXCR-4) and CXCR-7 and regulatory proteins of homing pathways, we administered atenolol, carvedilol, metoprolol and propranolol for 30 days using an orogastric tube to hypertensive rats. METHOD: We collected blood samples before and after treatment and quantified the levels of SDF-1 with enzyme linked immunosorbent assay (ELISA)...
May 12, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29748049/identification-and-preliminary-structure-activity-relationship-studies-of-novel-pyridyl-sulfonamides-as-potential-chagas-disease-therapeutic-agents
#12
Raiza Brandão Peres, Asma Inam Ullah, Ludmila Ferreira de Almeida Fiuza, Patricia Bernardino Silva, Marcos M Batista, Olivia Corcoran, Tummala Rama Krishna Reddy, Maria de Nazaré Correia Soeiro
Chagas disease is a neglected pathology responsible for about 12,000 deaths every year across Latin America. Although six million people are infected by the Trypanosoma cruzi, current therapeutic options are limited, highlighting the need for new drugs. Here we report the preliminary structure activity relationships of a small library of 17 novel pyridyl sulfonamide derivatives. Analogues 4 and 15 displayed significant potency against intracellular amastigotes with EC50 of 5.4 µM and 8.6 µM. In cytotoxicity assays using mice fibroblast L929 cell lines, both compounds indicated low toxicity with decent selectivity indices (SI) >36 and >23 respectively...
April 30, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29745048/new-1-2-3-triazole-based-analogues-of-benznidazole-for-use-against-trypanosoma-cruzi-infection-in-vitro-and-in-vivo-evaluations
#13
Débora Inácio Leite, Fábio de Vasconcellos Fontes, Monica Macedo Bastos, Lucas Villas Boas Hoelz, Maria da Conceição Avelino Dias Bianco, Andressa Paula de Oliveira, Patricia Bernardino da Silva, Cristiane França da Silva, Denise da Gama Jean Batista, Aline Nefertiti Silva da Gama, Raiza Brandão Peres, Jose Daniel Figueroa Villar, Maria de Nazaré Correia Soeiro, Nubia Boechat
Chagas disease (CD) has spread throughout the world mainly because of the migration of infected individuals. In Brazil, only benznidazole (Bnz) is used; however, it is toxic and not active in the chronic phase, and cases of resistance are described. This work aimed at the synthesis and the trypanocidal evaluation in vitro and in vivo of six new Bnz analogues (3-8). They were designed by exploring the bioisosteric substitution between the amide group contained in Bnz and the 1,2,3-triazole ring. All the compounds were synthesized in good yields...
May 9, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29744246/comparative-study-of-three-methods-for-depth-of-central-venous-catheter-placement-in-children-an-observational-pilot-study
#14
Vaishali Chaskar, Priyanka Pradeep Karnik, Nandini Malay Dave, Madhu Garasia
Objective: Central venous cannulation of the internal jugular vein is difficult in paediatric patients because of the small size of the vein and anatomic variations. Many studies have shown the accuracy of various formulae for calculating the depth of placement. The aim of this study was to assess the most reliable method for central venous catheter (CVC) tip placement in paediatric patients. Methods: Sixty-nine patients in the age groups from 0 to 12 years were divided in three groups for three published techniques for catheter tip placement...
April 2018: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29743275/thermodynamic-constraints-for-identifying-elementary-flux-modes
#15
REVIEW
Sabine Peres, Stefan Schuster, Philippe Dague
Metabolic pathway analysis is a key method to study metabolism and the elementary flux modes (EFMs) is one major concept allowing one to analyze the network in terms of minimal pathways. Their practical use has been hampered by the combinatorial explosion of their number in large systems. The EFMs give the possible pathways at steady state, but the real pathways are limited by biological constraints. In this review, we display three different methods that integrate thermodynamic constraints in terms of Gibbs free energy in the EFMs computation...
May 9, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29742233/income-trajectories-affect-treatment-of-dental-caries-from-childhood-to-young-adulthood-a-birth-cohort-study
#16
Marco Aurelio Peres, Pingzhou Liu, Flavio Fernando Demarco, Alexandre Emidio Ribeiro Silva, Fernando Cesar Wehrmeister, Ana Maria Menezes, Karen Glazer Peres
We aimed to analyze the effects of family income trajectories on the increase in dental caries from childhood to young adulthood. Data from the 1993 Pelotas (Brazil) birth cohort study, in which dental caries was measured at ages 6, 12, and 18 years, were analyzed. Family income of 302 participants was assessed at birth, and at 4, 11, 15, and 18 years of age. Mother's education, toothbrushing frequency, dental visiting, dental caries in primary dentition, and birth weight were covariates. A latent class growth analysis was conducted to characterize trajectories of time-varying variables...
2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29740435/a-beneficial-effect-of-low-dose-aspirin-in-a-murine-model-of-active-tuberculosis
#17
Vera Marie Kroesen, Paula Rodríguez-Martínez, Eric García, Yaiza Rosales, Jorge Díaz, Montse Martín-Céspedes, Gustavo Tapia, Maria Rosa Sarrias, Pere-Joan Cardona, Cristina Vilaplana
An excessive, non-productive host-immune response is detrimental in active, chronic tuberculosis (TB) disease as it typically leads to tissue damage. Given their anti-inflammatory effect, non-steroidal anti-inflammatory drugs can potentially attenuate excessive inflammation in active TB disease. As such, we investigated the prophylactic and therapeutic effect of low-dose aspirin (LDA) (3 mg/kg/day), either alone or in combination with common anti-TB treatment or BCG vaccination, on disease outcome in an experimental murine model of active TB...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29734376/correction-contribution-of-the-ankle-brachial-index-to-improve-the-prediction-of-coronary-risk-the-artper-cohort
#18
Rosa Forés, Maria Teresa Alzamora, Guillem Pera, José Miguel Baena-Díez, Xavier Mundet-Tuduri, Pere Torán
[This corrects the article DOI: 10.1371/journal.pone.0191283.].
2018: PloS One
https://www.readbyqxmd.com/read/29730415/anticancer-activity-of-flavonoids-isolated-from-achyrocline-satureioides-in-gliomas-cell-lines
#19
Priscila Oliveira de Souza, Sara Elis Bianchi, Fabrício Figueiró, Luana Heimfarth, Karla Suzana Moresco, Rosângela Mayer Gonçalves, Juliana Bender Hoppe, Caroline Peres Klein, Christianne Gazzana Salbego, Daniel Pens Gelain, Valquíria Linck Bassani, Alfeu Zanotto Filho, José Claudio Fonseca Moreira
Achyrocline satureioides, popularly known as "marcela", is a medicinal plant found in South America. This plant is rich in flavonoids, which have been reported to exert numerous biological activities. The aim of this study was to purify, identify and evaluate the mechanisms underlining anticancer activity of A. satureioides flavonoids in glioma cell lines (U87, U251 and C6) as well as their comparative toxicity in normal brain cells (primary astrocytes, neurons and organotypic hippocampal cultures)...
May 3, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29729739/novel-automated-workflow-for-spectral-alignment-and-mass-calibration-in-ms-imaging-using-a-sputtered-ag-nanolayer
#20
Pere Ràfols, Esteban Del Castillo, Oscar Yanes, Jesús Brezmes, Xavier Correig
Mass spectrometry imaging (MSI) is a technique that can map analyte spatial distribution directly onto a tissue section. This enables the spatial correlation of molecular entities with a tissue morphology to be investigated. Analyte annotation in MSI is intrinsically linked to the mass accuracy of the data. Mass accuracy and analyte identification are determined by such factors as the experimental set up and the data processing workflow. We present an MSI data processing workflow that uses a label-free approach to compensate for mass shifts...
August 31, 2018: Analytica Chimica Acta
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