Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Léa Domitien Payet, Anne Sophie Bedin, Émilie Desselas, Carole Marie-Jeanne, Caroline Mollevi, Fabrice Malergue, Penelope Bourgoin, Philippe Van de Perre, Édouard Tuaillon, Éric Jeziorski
In adults, monocytes and neutrophils play important roles in the hyper-inflammatory responses' characteristic of severe forms of SARS-CoV-2 infection. We assessed leukocyte activation in 55 children attending the emergency department for acute fever between March 2020 and September 2021. The following markers were analyzed by flow cytometry: CD169 and HLA-DR on monocytes, CD64 and CD16 on neutrophils, CD38 on lymphocytes TCD8. Fifteen of the children had SARS-CoV-2 infection, 15 had bacterial infections, 15 had inflammatory diseases...
April 22, 2024: Journal of Leukocyte Biology
#2
JOURNAL ARTICLE
Monica Simeoni, Shuying Yang, Debra J Tompson, Richard Dimelow
Belimumab was approved for active lupus nephritis (LN) in adults in the European Union and patients ≥ 5 years of age in the USA based on a Phase 3, double-blind, placebo-controlled, 104-week study. The study evaluated the efficacy of belimumab plus background standard therapy in adults with active LN using an intravenous (IV) dose of 10 mg/kg. A longitudinal analysis of Primary Efficacy Renal Response (PERR) and Complete Renal Response (CRR) was performed to assess whether patients with high proteinuria at the start of belimumab treatment would benefit from a higher dose...
March 29, 2024: Journal of Pharmacokinetics and Pharmacodynamics
#3
Dang Mao Nguyen, Thi My Hanh Diep, Yuri Ferreira da Silva, Thi Nhung Vu, DongQuy Hoang, Chi Nhan Ha Thuc, Quoc Bao Bui, Patrick Perré
No abstract text is available yet for this article.
March 27, 2024: International Journal of Biological Macromolecules
#4
JOURNAL ARTICLE
Lissett E Martínez, Gerardo Gómez, Norma Ramírez, Bernardo Franco, Eduardo A Robleto, Mario Pedraza-Reyes
The guanine oxidized (GO) system of Bacillus subtilis , composed of the YtkD (MutT), MutM and MutY proteins, counteracts the cytotoxic and genotoxic effects of the oxidized nucleobase 8-OxoG. Here, we report that in growing B. subtilis cells, the genetic inactivation of GO system potentiated mutagenesis (HPM), and subsequent hyperresistance, contributes to the damaging effects of hydrogen peroxide (H2 O2 ) (HPHR). The mechanism(s) that connect the accumulation of the mutagenic lesion 8-OxoG with the ability of B...
March 8, 2024: Antioxidants (Basel, Switzerland)
#5
JOURNAL ARTICLE
Philippe Van de Perre, Gabriella Scarlatti, Penny L Moore, Jean-Pierre Molès, Nicolas Nagot, Thorkild Tylleskär, Glenda Gray, Ameena Goga
No abstract text is available yet for this article.
March 2024: Immunity, Inflammation and Disease
#6
JOURNAL ARTICLE
Abda Ba, Vincent Roumy, Malak Al Ibrahim, Imelda Raczkiewicz, Jennifer Samaillie, Asma Hakem, Sevser Sahpaz, Sandrine Belouzard, William Diatta, Mamadou Sidybé, Christel Neut, Karin Séron, Matar Seck, Céline Rivière
ETHNOPHARMACOLOGICAL RELEVANCE: In Senegal, upper and lower respiratory tract infections constitute a real health problem. To manage these disorders, most people rely on the use of local medicinal plants. This is particularly the case for species belonging to the botanical families, Combretaceae, Fabaceae, Myrtaceae and Rubiaceae, which are widely used to treat various respiratory problems such as colds, flu, rhinitis, sinusitis, otitis, angina, bronchitis, bronchiolitis and also pneumonia...
March 21, 2024: Journal of Ethnopharmacology
#7
REVIEW
Yusmel González-Hernández, Patrick Perré
This paper reviews the key building blocks needed to develop a mechanistic model for use as an operational production tool. The Chinese Hamster Ovary (CHO) cell, one of the most widely used hosts for antibody production in the pharmaceutical industry, is considered as a case study. CHO cell metabolism is characterized by two main phases, exponential growth followed by a stationary phase with strong protein production. This process presents an appropriate degree of complexity to outline the modeling strategy...
June 2024: Metabolic Engineering Communications
#8
RANDOMIZED CONTROLLED TRIAL
Chipepo Kankasa, Anaïs Mennecier, Beninwendé L D Sakana, Jean-Pierre Molès, Mwiya Mwiya, Catherine Chunda-Liyoka, Morgana D'Ottavi, Souleymane Tassembedo, Maria M Wilfred-Tonga, Paulin Fao, David Rutagwera, Beauty Matoka, Dramane Kania, Ousmane A Taofiki, Thorkild Tylleskär, Philippe Van de Perre, Nicolas Nagot
BACKGROUND: Transmission through breastfeeding accounts for more than half of the unacceptably high number of new paediatric HIV infections worldwide. We hypothesised that, in addition to maternal antiretroviral therapy (ART), extended postnatal prophylaxis with lamivudine, guided by point-of-care assays for maternal viral load, could reduce postnatal transmission. METHODS: We did a phase 3, open-label, randomised controlled trial at four health-care facilities in Zambia and four health-care facilities in Burkina Faso...
April 6, 2024: Lancet
#9
JOURNAL ARTICLE
Souleymane Tassembédo, Isidore Tiandiogo Traoré, Makoura Traoré-Barro, Ismael Diallo, Daouda Maré, Fatimata Diallo-Barry, Camille Rajaonarivelo, Bethem Coulibaly, Amélie Nikiema, Armel Poda, Philippe Vande Perre, Nicolas Nagot
OBJECTIVE: To estimate the feasibility, positivity rate and cost of offering child testing for human immunodeficiency virus (HIV) to mothers living with HIV attending outpatient clinics in Burkina Faso. METHODS: We conducted this implementation study in nine outpatient clinics between October 2021 and June 2022. We identified all women ≤ 45 years who were attending these clinics for their routine HIV care and who had at least one living child aged between 18 months and 5 years whose HIV status was not known...
March 1, 2024: Bulletin of the World Health Organization
#10
REVIEW
Xingqun Cheng, Xin Xu, Xuedong Zhou, Jia Ning
Oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is linked to the occurrence and development of dental caries. The ability of S. mutans to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of S. mutans include synthesis of reductase, regulation of metal ions uptake, regulator PerR, transcription regulator Spx, extracellular uptake of glutathione, and other related signal transduction systems...
2024: Journal of Oral Microbiology
#11
JOURNAL ARTICLE
Sajith Raghunandanan, Raj Priya, Fuad Alanazi, Meghan C Lybecker, Paula Jean Schlax, X Frank Yang
The σ54-σS sigma factor cascade plays a central role in regulating differential gene expression during the enzootic cycle of Borreliella burgdorferi, the Lyme disease pathogen. In this pathway, the primary transcription of rpoS (which encodes σS) is under the control of σ54 which is activated by a bacterial enhancer-binding protein (EBP), Rrp2. The σ54-dependent activation in B. burgdorferi has long been thought to be unique, requiring an additional factor, BosR, a homologue of classical Fur/PerR repressor/activator...
February 15, 2024: Nucleic Acids Research
#12
JOURNAL ARTICLE
Hayley S Clements, Emmanuel Do Linh San, Gareth Hempson, Birthe Linden, Bryan Maritz, Ara Monadjem, Chevonne Reynolds, Frances Siebert, Nicola Stevens, Reinette Biggs, Alta De Vos, Ryan Blanchard, Matthew Child, Karen J Esler, Maike Hamann, Ty Loft, Belinda Reyers, Odirilwe Selomane, Andrew L Skowno, Tshegofatso Tshoke, Diarrassouba Abdoulaye, Thierry Aebischer, Jesús Aguirre-Gutiérrez, Graham J Alexander, Abdullahi H Ali, David G Allan, Esther E Amoako, Samuel Angedakin, Edward Aruna, Nico L Avenant, Gabriel Badjedjea, Adama Bakayoko, Abraham Bamba-Kaya, Michael F Bates, Paul J J Bates, Steven R Belmain, Emily Bennitt, James Bradley, Chris A Brewster, Michael B Brown, Michelle Brown, Josef Bryja, Thomas M Butynski, Filipe Carvalho, Alan Channing, Colin A Chapman, Callan Cohen, Marina Cords, Jennifer D Cramer, Nadine Cronk, Pamela M K Cunneyworth, Fredrik Dalerum, Emmanuel Danquah, Harriet T Davies-Mostert, Andrew D de Blocq, Yvonne A De Jong, Terrence C Demos, Christiane Denys, Chabi A M S Djagoun, Thomas M Doherty-Bone, Marine Drouilly, Johan T du Toit, David A Ehlers Smith, Yvette C Ehlers Smith, Seth J Eiseb, Peter J Fashing, Adam W Ferguson, José M Fernández-García, Manfred Finckh, Claude Fischer, Edson Gandiwa, Philippe Gaubert, Jerome Y Gaugris, Dalton J Gibbs, Jason S Gilchrist, Jose M Gil-Sánchez, Anthony N Githitho, Peter S Goodman, Laurent Granjon, J Paul Grobler, Bonginkosi C Gumbi, Vaclav Gvozdik, James Harvey, Morgan Hauptfleisch, Firas Hayder, Emmanuel M Hema, Marna Herbst, Mariano Houngbédji, Brian J Huntley, Rainer Hutterer, Samuel T Ivande, Kate Jackson, Gregory F M Jongsma, Javier Juste, Blaise Kadjo, Prince K Kaleme, Edwin Kamugisha, Beth A Kaplin, Humphrey N Kato, Christian Kiffner, Duncan M Kimuyu, Robert M Kityo, N'goran G Kouamé, Marcel Kouete T, Aliza le Roux, Alan T K Lee, Mervyn C Lötter, Anne Mette Lykke, Duncan N MacFadyen, Gacheru P Macharia, Zimkitha J K Madikiza, Themb'alilahlwa A M Mahlaba, David Mallon, Mnqobi L Mamba, Claude Mande, Rob A Marchant, Robin A Maritz, Wanda Markotter, Trevor McIntyre, John Measey, Addisu Mekonnen, Paulina Meller, Haemish I Melville, Kevin Z Mganga, Michael G L Mills, Liaan Minnie, Alain Didier Missoup, Abubakr Mohammad, Nancy N Moinde, Bakwo Fils E Moise, Pedro Monterroso, Jennifer F Moore, Simon Musila, Sedjro Gilles A Nago, Maganizo W Namoto, Fatimata Niang, Violaine Nicolas, Jerry B Nkenku, Evans E Nkrumah, Gonwouo L Nono, Mulavwa M Norbert, Katarzyna Nowak, Benneth C Obitte, Arnold D Okoni-Williams, Jonathan Onongo, M Justin O'Riain, Samuel T Osinubi, Daniel M Parker, Francesca Parrini, Mike J S Peel, Johannes Penner, Darren W Pietersen, Andrew J Plumptre, Damian W Ponsonby, Stefan Porembski, R John Power, Frans G T Radloff, Ramugondo V Rambau, Tharmalingam Ramesh, Leigh R Richards, Mark-Oliver Rödel, Dominic P Rollinson, Francesco Rovero, Mostafa A Saleh, Ute Schmiedel, M Corrie Schoeman, Paul Scholte, Thomas L Serfass, Julie Teresa Shapiro, Sidney Shema, Stefan J Siebert, Jasper A Slingsby, Alexander Sliwa, Hanneline A Smit-Robinson, Etotepe A Sogbohossou, Michael J Somers, Stephen Spawls, Jarryd P Streicher, Lourens Swanepoel, Iroro Tanshi, Peter J Taylor, William A Taylor, Mariska Te Beest, Paul T Telfer, Dave I Thompson, Elie Tobi, Krystal A Tolley, Andrew A Turner, Wayne Twine, Victor Van Cakenberghe, Frederik Van de Perre, Helga van der Merwe, Chris J G van Niekerk, Pieter C V van Wyk, Jan A Venter, Luke Verburgt, Geraldine Veron, Susanne Vetter, Maria S Vorontsova, Thomas C Wagner, Paul W Webala, Natalie Weber, Sina M Weier, Paula A White, Melissa A Whitecross, Benjamin J Wigley, Frank J Willems, Christiaan W Winterbach, Galena M Woodhouse
Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on species' population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate 'intactness scores': the remaining proportion of an 'intact' reference population of a species group in a particular land use, on a scale from 0 (no remaining individuals) to 1 (same abundance as the reference) and, in rare cases, to 2 (populations that thrive in human-modified landscapes)...
February 12, 2024: Scientific Data
#13
JOURNAL ARTICLE
Carlos Cédric Ahoyo, Thierry Dèhouegnon Houéhanou, Alain Sèakpo Yaoitcha, Bénédicte Perpétue Akpi, Armand Natta, Marcel Romuald Benjamin Houinato
BACKGROUND: Several hypotheses have been used in ethnobotany to explain the plant's selection criteria by people for their daily needs. Thus, it is important to assess synergy and complementarity among them, especially, those concerning the plant use value, social dynamics and human traits. The study aims to (i) highlight people's socio-economic factors, and plant ecological traits that affect the plant use-availability dynamic (PUD); and (ii) assess the available species diversity effect on ethno-medicinal knowledge diversity in Benin...
February 9, 2024: Journal of Ethnobiology and Ethnomedicine
#14
JOURNAL ARTICLE
Cristina Sarasa-Buisan, Mercedes Nieves-Morión, Sergio Arévalo, Richard F Helm, Emma Sevilla, Ignacio Luque, María F Fillat
Microbial extracellular proteins and metabolites provide valuable information concerning how microbes adapt to changing environments. In cyanobacteria, dynamic acclimation strategies involve a variety of regulatory mechanisms, being ferric uptake regulator proteins as key players in this process. In the nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120, FurC (PerR) is a global regulator that modulates the peroxide response and several genes involved in photosynthesis and nitrogen metabolism. To investigate the possible role of FurC in shaping the extracellular environment of Anabaena , the analysis of the extracellular metabolites and proteins of a furC -overexpressing variant was compared to that of the wild-type strain...
February 9, 2024: MBio
#15
JOURNAL ARTICLE
Emily Stoakes, Xuanlin Chen, Lajos Kalmar, Dave Baker, Rhiannon Evans, Steven Rudder, Andrew J Grant
BACKGROUND: Campylobacter jejuni and Campylobacter coli are the major causative agents of bacterial gastroenteritis worldwide and are known obligate microaerophiles. Despite being sensitive to oxygen and its reduction products, both species are readily isolated from animal food products kept under atmospheric conditions where they face high oxygen tension levels. RESULTS: In this study, Transposon Directed Insertion-site Sequencing (TraDIS) was used to investigate the ability of one C...
February 1, 2024: BMC Microbiology
#16
Victor Pozzobon, Patrick Perré
No abstract text is available yet for this article.
January 25, 2024: Journal of Theoretical Biology
#17
JOURNAL ARTICLE
James Stanway, Nina Brown, Afeera Pervez, Els Van de Perre, James Tollitt, Nikolaos Marketos, Nikki Wong, Ajay Dhaygude, Arvind Ponnusamy, Ed O'Riordan, Michael Venning, Mårten Segelmark, Matthew Morgan, David Jayne, Patrick Hamilton, Charles D Pusey, Louise Oni, Alan D Salama
OBJECTIVES: IgA vasculitis (IgAV) in adults has been relatively under-investigated. Since outcomes are worse in other forms of vasculitis with increasing age, we investigated the outcomes of IgAV comparing younger adults (18-34), middle aged adults (35-64) and elderly patients (≥64 years) focusing on kidney outcomes. METHODS: We identified patients with renal biopsy confirmed IgAV nephritis and collected data regarding clinical features and progression to end stage kidney disease (ESKD)...
January 25, 2024: Rheumatology
#18
JOURNAL ARTICLE
Fernando Tortosa, Fernando Perre, Gabriela Carrasco, Gonzalo De Lusarreta, Natalia Artola, Dana Prandi, Rodrigo Bustamante, German Guaresti, Ariel Izcovich
INTRODUCTION: The objective of this study was to analyze the geographic variability and the relationship between social determinants of health and COVID-19 lethality in Bariloche. METHODS: A database from the National Epidemiological Surveillance System was used to analyze COVID-19 positive cases from January 2020 to December 2021. The data were geocoded and incorporated into a geographic information system (GIS). A three-step analytical framework was applied to measure health inequity, using socioeconomic indicators and access to services...
2024: Medicina
#19
JOURNAL ARTICLE
Avital Savin, Exene E Anderson, Sophie Dyzenhaus, Magdalena Podkowik, Bo Shopsin, Alejandro Pironti, Victor J Torres
Staphylococcus aureus utilizes a diverse set of virulence factors, such as leukocidins, to subvert human neutrophils, but how these toxins are regulated is incompletely defined. Here, we identified the peroxide-sensitive repressor, PerR, as a required protein involved in the induction of lukAB in the presence of primary human neutrophils, a phenotype directly linked to the ability of PerR to sense H2 O. Thus, we show that S. aureus coordinates sensing and resistance to oxidative stress with toxin production to promote pathogen survival...
January 18, 2024: Infection and Immunity
#20
JOURNAL ARTICLE
Yan Gao, Olivier Bernard, Andrea Fanesi, Patrick Perré, Filipa Lopes
The interest by biofilm-based microalgae technologies has increased lately due to productivity improvement, energy consumption reduction and easy harvesting. However, the effect of light, one key factor for system's operation, received less attention than for planktonic cultures. This work assessed the impact of Photon Flux Density (PFD) on Chlorella vulgaris biofilm dynamics (structure, physiology, activity). Microalgae biofilms were cultivated in a flow-cell system with PFD from 100 to 500 [Formula: see text]...
January 11, 2024: Scientific Reports
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
