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https://www.readbyqxmd.com/read/28585778/intensified-biobutanol-recovery-using-zeolites-with-complementary-selectivity
#1
Stijn Van der Perre, Pierre Gelin, Benjamin Claessens, Ana Martin-Calvo, Julien Cousin Saint Remi, Tim Duerinck, Gino V Baron, Miguel Palomino, Ledys Y Sanchez, Susana Valencia, Jin Shang, Ranjeet Singh, Paul A Webley, Fernando Rey, Joeri Denayer
A vapor phase adsorptive recovery process is proposed as an alternative way to isolate biobutanol from acetone-butanol-ethanol (ABE) fermentation media, offering several advantages compared to liquid phase separation. The effect of water, which is still present in large quantities in vapor phase, on the adsorption of the organics could be minimized by using hydrophobic zeolites. Shape selective all-silica zeolites CHA and LTA were prepared and evaluated via single component isotherms and breakthrough experiments...
June 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28486519/changes-in-body-mass-index-and-hemoglobin-concentration-in-breastfeeding-women-living-with-hiv-with-a-cd4-count-over-350-results-from-4-african-countries-the-anrs-12174-trial
#2
Eric Nagaonlé Somé, Ingunn M S Engebretsen, Nicolas Nagot, Nicolas Y Meda, Roselyne Vallo, Chipepo Kankasa, James K Tumwine, Mandisa Singata, Justus G Hofmeyr, Philippe Van de Perre, Thorkild Tylleskär
INTRODUCTION: Breastfeeding is recommended for infants born to HIV-infected women in low-income settings. Both breastfeeding and HIV-infection are energy demanding. Our objective was to explore how exclusive and predominant breastfeeding changes body mass index (BMI) among breastfeeding HIV1-positive women participating in the ANRS12174 trial (clinical trial no NCT0064026). METHODS: HIV-positive women (n = 1 267) with CD4 count >350, intending to breastfeed HIV-negative infants were enrolled from Burkina Faso, South Africa, Uganda and Zambia and counselled on breastfeeding...
2017: PloS One
https://www.readbyqxmd.com/read/28475354/role-of-glucagon-in-catabolism-and-muscle-wasting-of-critical-illness-and-modulation-by-nutrition
#3
Steven E Thiessen, Sarah Derde, Inge Derese, Thomas Dufour, Chloé Albert Vega, Lies Langouche, Chloë Goossens, Nele Peersman, Pieter Vermeersch, Sarah Vander Perre, Jens J Holst, Pieter J Wouters, Ilse Vanhorebeek, Greet Van den Berghe
RATIONALE: Critical illness is hallmarked by muscle wasting and disturbances in glucose, lipid and amino acid homeostasis. Circulating concentrations of glucagon, a catabolic hormone that affects these metabolic pathways, are elevated during critical illness. Insight in the nutritional regulation of glucagon and its metabolic role during critical illness is lacking. OBJECTIVES: We evaluated whether macronutrient infusion can suppress plasma glucagon during critical illness and studied the role of illness-induced glucagon abundance in the disturbed glucose, lipid and amino acid homeostasis and in muscle wasting during critical illness...
May 5, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28434406/efavirenz-based-simplification-after-successful-early-lopinavir-boosted-ritonavir-based-therapy-in-hiv-infected-children-in-burkina-faso-and-c%C3%A3-te-d-ivoire-the-monod-anrs-12206-non-inferiority-randomised-trial
#4
Désiré Lucien Dahourou, Madeleine Amorissani-Folquet, Karen Malateste, Clarisse Amani-Bosse, Malik Coulibaly, Carole Seguin-Devaux, Thomas Toni, Rasmata Ouédraogo, Stéphane Blanche, Caroline Yonaba, François Eboua, Philippe Lepage, Divine Avit, Sylvie Ouédraogo, Philippe Van de Perre, Sylvie N'Gbeche, Angèle Kalmogho, Roger Salamon, Nicolas Meda, Marguerite Timité-Konan, Valériane Leroy
BACKGROUND: The 2016 World Health Organization guidelines recommend all children <3 years start antiretroviral therapy (ART) on protease inhibitor-based regimens. But lopinavir/ritonavir (LPV/r) syrup has many challenges in low-income countries, including limited availability, requires refrigeration, interactions with anti-tuberculous drugs, twice-daily dosing, poor palatability in young children, and higher cost than non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs. Successfully initiating LPV/r-based ART in HIV-infected children aged <2 years raises operational challenges that could be simplified by switching to a protease inhibitor-sparing therapy based on efavirenz (EFV), although, to date, EFV is not recommended in children <3 years...
April 24, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28434086/the-inability-of-bacillus-licheniformis-perr-mutant-to-grow-is-mainly-due-to-the-lack-of-perr-mediated-fur-repression
#5
Jung-Hoon Kim, Yoon-Mo Yang, Chang-Jun Ji, Su-Hyun Ryu, Young-Bin Won, Shin-Yeong Ju, Yumi Kwon, Yeh-Eun Lee, Hwan Youn, Jin-Won Lee
PerR, a member of Fur family protein, is a metal-dependent H2O2 sensing transcription factor that regulates genes involved in peroxide stress response. Industrially important bacterium Bacillus licheniformis contains three PerR-like proteins (PerRBL, PerR2, and PerR3) compared to its close relative Bacillus subtilis. Interestingly, unlike other bacteria including B. subtilis, no authentic perR BL null mutant could be established for B. licheniformis. Thus, we constructed a conditional perR BL mutant using a xylose-inducible promoter, and investigated the genes under the control of PerRBL...
June 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28402453/medina%C3%A2-embolization-device-for-the-treatment-of-intracranial-aneurysms-safety-and-angiographic-effectiveness-at-6-months
#6
Nader-Antoine Sourour, Saskia Vande Perre, Federico Di Maria, Chrysanthi Papagiannaki, Joseph Gabrieli, Silvia Pistocchi, Bruno Bartolini, Vincent Degos, Alexandre Carpentier, Jacques Chiras, Frédéric Clarençon
BACKGROUND: The Medina Embolization Device (MED) is a new concept device that combines the design of a detachable coil and the one of an intrasaccular flow disruption device. OBJECTIVE: To evaluate the feasibility, safety, and 6- to 9-mo effectiveness of this new device for the treatment of intracranial wide-necked aneurysms. METHODS: Twelve patients (10 females, mean age = 56 yr) with 13 wide-necked intracranial aneurysms (3 ruptured; 10 unruptured) were treated by means of the MED from January 2015 to October 2015...
April 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28373352/the-perr-regulated-p1b-4-type-atpase-pmta-acts-as-a-ferrous-iron-efflux-pump-in-streptococcus-pyogenes
#7
Andrew G Turner, Cheryl-Lynn Y Ong, Karrera Y Djoko, Nicholas P West, Mark R Davies, Alastair G McEwan, Mark J Walker
Streptococcus pyogenes (group A Streptococcus [GAS]) is an obligate human pathogen responsible for a broad spectrum of human disease. GAS has a requirement for metal homeostasis within the human host and, as such, tightly modulates metal uptake and efflux during infection. Metal acquisition systems are required to combat metal sequestration by the host, while metal efflux systems are essential to protect against metal overload poisoning. Here, we investigated the function of PmtA (PerR-regulated metal transporter A), a P1B-4-type ATPase efflux pump, in invasive GAS M1T1 strain 5448...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28348051/iron-efflux-by-pmta-is-critical-for-oxidative-stress-resistance-and-contributes-significantly-to-group-a-streptococcus-virulence
#8
Arica R VanderWal, Nishanth Makthal, Azul Pinochet-Barros, John D Helmann, Randall J Olsen, Muthiah Kumaraswami
Group A Streptococcus (GAS) is a human-only pathogen that causes a spectrum of disease conditions. Given its survival in inflamed lesions, the ability to sense and overcome oxidative stress is critical for GAS pathogenesis. PerR senses oxidative stress and coordinates the regulation of genes involved in GAS antioxidant defenses. In this study, we investigated the role of PerR-controlled metal transporter A (PmtA) in GAS pathogenesis. Previously, PmtA was implicated in GAS antioxidant defenses and suggested to protect against zinc toxicity...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28303483/proliferation-and-differentiation-of-adipose-tissue-in-prolonged-lean-and-obese-critically-ill-patients
#9
Chloë Goossens, Sarah Vander Perre, Greet Van den Berghe, Lies Langouche
BACKGROUND: In prolonged non-obese critically ill patients, preservation of adipose tissue is prioritized over that of the skeletal muscle and coincides with increased adipogenesis. However, we recently demonstrated that in obese critically ill mice, this priority was switched. In the obese, the use of abundantly available adipose tissue-derived energy substrates was preferred and counteracted muscle wasting. These observations suggest that different processes are ongoing in adipose tissue of lean vs...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28279960/pre-exposure-prophylaxis-for-infants-exposed-to-hiv-through-breast-feeding
#10
Philippe Van de Perre, Chipepo Kankasa, Nicolas Nagot, Nicolas Meda, James K Tumwine, Anna Coutsoudis, Thorkild Tylleskär, Hoosen Coovadia
No abstract text is available yet for this article.
March 9, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28272163/real-world-efficacy-of-daclatasvir-and-sofosbuvir-with-and-without-ribavirin-in-hiv-hcv-coinfected-patients-with-advanced-liver-disease-in-a-french-early-access-cohort
#11
Karine Lacombe, Hélène Fontaine, Catherine Dhiver, Sophie Metivier, Eric Rosenthal, Teresa Antonini, Marc Antoine Valantin, Patrick Miailhes, Stanislas Harent, Dominique Batisse, Georges-Philippe Pageaux, Julie Chas, Hugues Aumaitre, Stephanie Dominguez, Thierry Allegre, Alain Lafeuillade, Eric Billaud, Pierre De Truchis, Philippe Perre, Vincent Leroy, Victor De Ledinghen, Philippe Sogni, François Dabis, Yue Zhao, Anne Filipovics, Larysa Fedchuk, Raoudha Akremi, Yacia Bennai, Dominique Salmon Ceron
BACKGROUND: Efficacious, well-tolerated, direct antiviral agents have drastically changed the prognosis of hepatitis C virus (HCV) disease, but real-world data for oral treatments are limited in key populations such as HIV/HCV coinfection with advanced liver disease. Daclatasvir (DCV) efficacy and safety was assessed in the French "Autorisation Temporaire d'Utilisation" (ATU) program, providing DCV ahead of market authorization to patients with advanced HCV disease without other treatment options...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28210250/simultaneous-activation-of-iron-and-thiol-based-sensor-regulator-systems-by-redox-active-compounds
#12
Kang-Lok Lee, Ji-Sun Yoo, Gyeong-Seok Oh, Atul K Singh, Jung-Hye Roe
Bacteria in natural habitats are exposed to myriad redox-active compounds (RACs), which include producers of reactive oxygen species (ROS) and reactive electrophile species (RES) that alkylate or oxidize thiols. RACs can induce oxidative stress in cells and activate response pathways by modulating the activity of sensitive regulators. However, the effect of a certain compound on the cell has been investigated primarily with respect to a specific regulatory pathway. Since a single compound can exert multiple chemical effects in the cell, its effect can be better understood by time-course monitoring of multiple sensitive regulatory pathways that the compound induces...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28104400/the-difference-in-in%C3%A2-vivo-sensitivity-between-bacillus-licheniformis-perr-and-bacillus-subtilis-perr-is-due-to-the-different-cellular-environments
#13
Jung-Hoon Kim, Young-Bin Won, Chang-Jun Ji, Yoon-Mo Yang, Su-Hyun Ryu, Shin-Yeong Ju, Yumi Kwon, Yeh-Eun Lee, Jin-Won Lee
PerR, a member of Fur family of metal-dependent regulators, is a major peroxide sensor in many Gram positive bacteria, and controls the expression of genes involved in peroxide resistance. Bacillus licheniformis, a close relative to the well-studied model organism Bacillus subtilis, contains three PerR-like proteins (PerRBL, PerR2 and PerR3) in addition to Fur and Zur. In the present study, we characterized the role of PerRBL in B. licheniformis. In vitro and in vivo studies indicate that PerRBL, like PerRBS, uses either Fe(2+) or Mn(2+) as a corepressor and only the Fe(2+)-bound form of PerRBL senses low levels of H2O2 by iron-mediated histidine oxidation...
February 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28099473/the-staphylococcus-aureus-srrab-regulatory-system-modulates-hydrogen-peroxide-resistance-factors-which-imparts-protection-to-aconitase-during-aerobic-growth
#14
Ameya A Mashruwala, Jeffrey M Boyd
The SrrAB two-component regulatory system (TCRS) positively influences the transcription of genes involved in aerobic respiration in response to changes in respiratory flux. Hydrogen peroxide (H2O2) can arise as a byproduct of spontaneous interactions between dioxygen and components of respiratory pathways. H2O2 damages cellular factors including protein associated iron-sulfur cluster prosthetic groups. We found that a Staphylococcus aureus strain lacking the SrrAB two-component regulatory system (TCRS) is sensitive to H2O2 intoxication...
2017: PloS One
https://www.readbyqxmd.com/read/28095445/cytosolic-rna-dna-duplexes-generated-by-endogenous-reverse-transcriptase-activity-as-autonomous-inducers-of-skin-inflammation-in-psoriasis
#15
Jean-Pierre Molès, Anthony Griez, Jean-Jacques Guilhou, Céline Girard, Nicolas Nagot, Philippe Van de Perre, Pierre Dujols
Psoriasis is a chronic skin disease of unknown ætiology. Recent studies suggested that a large amount of cytosolic DNA (cyDNA) in keratinocytes is breaking keratinocytes DNA tolerance and promotes self-sustained inflammation in the psoriatic lesion. We investigated the origin of this cyDNA. We show that, amongst all the possible DNA structures, the cyDNA could be present as RNA:DNA duplexes in keratinocytes. We further show that endogenous reverse transcriptase activities generate such duplexes and consequently activate the production of Th1-inflammatory cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28087802/cytochrome-c-peroxidase-ccp-is-a-molecular-determinant-of-the-oxidative-stress-response-in-the-extreme-acidophilic-leptospirillum-sp-cf-1
#16
Claudia Zapata, Braulio Paillavil, Renato Chávez, Pamela Álamos, Gloria Levicán
Bioleaching processes are used to recover metals from sulfidic ores. Biofilm formation on ores is important for bioleaching because the attached microorganisms start the leaching process by concentrating ferric ions in the extracellular matrix. It has been shown that hydrogen peroxide is spontaneously generated on the surface of ores and that it negatively influences the growth and activity of microorganisms. However, the mechanism by which bioleaching microorganisms tolerate exogenous H2O2 as an adaptive trait remains elusive...
March 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28070293/functional-community-structure-of-african-monodominant-gilbertiodendron-dewevrei-forest-influenced-by-local-environmental-filtering
#17
Elizabeth Kearsley, Hans Verbeeck, Koen Hufkens, Frederik Van de Perre, Sebastian Doetterl, Geert Baert, Hans Beeckman, Pascal Boeckx, Dries Huygens
Monodominant patches of forest dominated by Gilbertiodendron dewevrei are commonly found in central African tropical forests, alongside forests with high species diversity. Although these forests are generally found sparsely distributed along rivers, their occurrence is not thought to be (clearly) driven by edaphic conditions but rather by trait combinations of G. dewevrei that aid in achieving monodominance. Functional community structure between these monodominant and mixed forests has, however, not yet been compared...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28069472/semi-quantitative-real-time-pcr-a-useful-approach-to-identify-persons-with-low-replicative-chronic-hepatitis-b
#18
Joany Castéra-Guy, Pierre-Alain Rubbo, Dramane Kania, Maud Lemoine, Philippe Van de Perre, Edouard Tuaillon
Antiviral therapy can be avoided during the low replicative phase of chronic Hepatitis B virus (HBV) infection which is characterized notably by HBV DNA concentration below 2000IU/ml. Simplified diagnostic tests can improve access to HBV DNA monitoring in resource-limited settings. The capacity of a new semi-quantitative real-time PCR approach based on sample-to-standard relative detection of the target to discriminate samples with HBV DNA levels above or below the clinical threshold of 2000IU/ml was compared to a quantitative assay (Roche CobasAmpliPrep/CobasTaqMan HBV Test v2...
January 7, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28054240/risk-of-adverse-outcomes-for-older-people-with-dementia-prescribed-antipsychotic-medication-a-population-based-e-cohort-study
#19
Michael Dennis, Laura Shine, Ann John, Amanda Marchant, Joanna McGregor, Ronan A Lyons, Sinead Brophy
INTRODUCTION: Over recent years there has been growing evidence of increased risk of mortality associated with antipsychotic use in older people with dementia. Although this concern combined with limited evidence of efficacy has informed guidelines restricting antipsychotic prescription in this population, the use of antipsycotics remains common. Many published studies only report short-term outcomes, are restricted to examining mortality and stroke risk or have other limitations. The aim of this study was to assess adverse outcomes associated with the use of antipsychotics in older people living with dementia in Wales (UK)...
June 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28019697/mixture-toxicity-of-phostebupirim-and-cyfluthrin-species-specific-responses
#20
Chloé de Perre, Tracye M Murphy, Michael J Lydy
Currently, the potential impact of insecticide mixtures to non-target organisms is still largely unknown, and needs additional studies. Therefore, the present study investigated the mixture toxicity of the organophosphate insecticide phostebupirim and pyrethroid insecticide cyfluthrin using four non-target species including Daphnia magna, Hyalella azteca, Pimephales promelas (fathead minnow), and Danio rerio (zebrafish). For each species, the toxicity of equipotent mixtures was compared to the expected toxicity estimated using the independent action (IA) and concentration addition (CA) models...
December 26, 2016: Environmental Toxicology and Chemistry
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