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https://www.readbyqxmd.com/read/27897405/premorbid-obesity-but-not-nutrition-prevents-critical-illness-induced-muscle-wasting-and-weakness
#1
Chloë Goossens, Mirna Bastos Marques, Sarah Derde, Sarah Vander Perre, Thomas Dufour, Steven E Thiessen, Fabian Güiza, Thomas Janssens, Greet Hermans, Ilse Vanhorebeek, Katrien De Bock, Greet Van den Berghe, Lies Langouche
BACKGROUND: The 'obesity paradox' of critical illness refers to better survival with a higher body mass index. We hypothesized that fat mobilized from excess adipose tissue during critical illness provides energy more efficiently than exogenous macronutrients and could prevent lean tissue wasting. METHODS: In lean and premorbidly obese mice, the effect of 5 days of sepsis-induced critical illness on body weight and composition, muscle wasting, and weakness was assessed, each with fasting and parenteral feeding...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27895016/are-prophylactic-and-therapeutic-target-concentrations-different-the-case-of-lopinavir-ritonavir-or-lamivudine-administered-to-infants-for-the-prevention-of-mother-to-child-hiv-1-transmission-during-breastfeeding
#2
Frantz Foissac, Jörn Blume, Jean-Marc Tréluyer, Thorkild Tylleskär, Chipepo Kankasa, Nicolas Meda, James K Tumwine, Mandisa Singata-Madliki, Kim Harper, Silvia M Illamola, Naïm Bouazza, Nicolas Nagot, Philippe Van de Perre, Stéphane Blanche, Déborah Hirt
The ANRS 12174 trial assessed the efficacy and tolerance of LPV/r versus 3TC prophylaxis administered to breastfed infants, whose HIV-infected mothers were not on ART. In this sub-study, we assessed LPV/r and 3TC pharmacokinetics to evaluate the percentage of infants with therapeutic plasma concentrations and to discuss these data in the context of a prophylactic treatment. Infants from the South African trial site underwent blood sampling for pharmacokinetic study at week 6, 26 and 38 of life. We applied a Bayesian approach to derive the 3TC and LPV pharmacokinetic parameters based on previously published pharmacokinetic models for HIV-infected children...
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27883170/macvia-lr-fighting-chronic-diseases-for-active-and-healthy-ageing-in-languedoc-roussillon-a-success-story-of-the-european-innovation-partnership-on-active-and-healthy-ageing
#3
J Bousquet, R Bourret, T Camuzat, P Augé, J Bringer, M Noguès, O Jonquet, J E de la Coussaye, J Ankri, M Cesari, O Guérin, B Vellas, H Blain, S Arnavielhe, A Avignon, B Combe, G Canovas, C Daien, G Dray, A Dupeyron, C Jeandel, I Laffont, D Laune, C Marion, E Pastor, J Y Pélissier, B Galan, J Reynes, J C Reuzeau, A Bedbrook, S Granier, P A Adnet, M Amouyal, B Alomène, P L Bernard, C Berr, D Caimmi, P G Claret, D J Costa, J P Cristol, P Fesler, D Hève, J Millot-Keurinck, D Morquin, G Ninot, M C Picot, N Raffort, F Roubille, A Sultan, J Touchon, V Attalin, C Azevedo, M Badin, K Bakhti, B Bardy, M P Battesti, X Bobia, C Boegner, S Boichot, H Y Bonnin, S Bouly, C Boubakri, J L Bourrain, G Bourrel, V Bouix, V Bruguière, S Cade, W Camu, V Carre, G Cavalli, G Cayla, R Chiron, P Coignard, F Coroian, P Costa, J Cottalorda, B Coulet, A L Coupet, M C Courrouy-Michel, P Courtet, V Cros, F Cuisinier, M Danko, P Dauenhauer, M Dauzat, M David, J M Davy, D Delignières, P Demoly, J Desplan, P Dujols, G Dupeyron, O Engberink, M Enjalbert, C Fattal, J Fernandes, M Fouletier, P Fraisse, P Gabrion, M Gellerat-Rogier, A Gelis, C Genis, N Giraudeau, A Y Goucham, F Gouzi, F Gressard, J C Gris, B Guillot, D Guiraud, V Handweiler, M Hayot, C Hérisson, C Heroum, D Hoa, S Jacquemin, S Jaber, D Jakovenko, C Jorgensen, P Kouyoudjian, R Lamoureux, L Landreau, M Lapierre, D Larrey, C Laurent, M S Léglise, J M Lemaitre, A Le Quellec, F Leclercq, S Lehmann, B Lognos, Cj M Lussert, A Makinson, K Mandrick, P Mares, P Martin-Gousset, A Matheron, G Mathieu, M Meissonnier, G Mercier, P Messner, C Meunier, M Mondain, R Morales, J Morel, D Mottet, P Nérin, P Nicolas, F Nouvel, D Paccard, G Pandraud, M P Pasdelou, J L Pasquié, K Patte, S Perrey, Y M Pers, F Portejoie, J L E Pujol, X Quantin, I Quéré, S Ramdani, J Ribstein, I Rédini-Martinez, S Richard, K Ritchie, J P Riso, F Rivier, J M Robine, C Rolland, E Royère, D Sablot, J L Savy, L Schifano, P Senesse, R Sicard, Y Stephan, D Strubel, G Tallon, M Tanfin, H Tassery, I Tavares, K Torre, V Tribout, A Uziel, P Van de Perre, F Venail, C Vergne-Richard, G Vergotte, L Vian, F Vialla, F Viart, M Villain, E Viollet, M Ychou, J Mercier
The Région Languedoc Roussillon is the umbrella organisation for an interconnected and integrated project on active and healthy ageing (AHA). It covers the 3 pillars of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA): (A) Prevention and health promotion, (B) Care and cure, (C) and (D) Active and independent living of elderly people. All sub-activities (poly-pharmacy, falls prevention initiative, prevention of frailty, chronic respiratory diseases, chronic diseases with multimorbidities, chronic infectious diseases, active and independent living and disability) have been included in MACVIA-LR which has a strong political commitment and involves all stakeholders (public, private, patients, policy makers) including CARSAT-LR and the Eurobiomed cluster...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27852856/zika-virus-efficiently-replicates-in-human-retinal-pigment-epithelium-and-disturbs-its-permeability
#4
Sara Salinas, Nejla Erkilic, Krishna Damodar, Jean-Pierre Molès, Chantal Fournier-Wirth, Philippe Van de Perre, Vasiliki Kalatzis, Yannick Simonin
Recently, the Flavivirus Zika virus (ZIKV) has rapidly spread in the Americas and in the Caribbean islands.….
November 16, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27835754/automatic-phonological-activation-during-visual-word-recognition-in-bilingual-children-a-cross-language-masked-priming-study-in-grades-3-and-5
#5
Karinne Sauval, Laetitia Perre, Lynne G Duncan, Eva Marinus, Séverine Casalis
Previous masked priming research has shown automatic phonological activation during visual word recognition in monolingual skilled adult readers. Activation also occurs across languages in bilingual adult readers, suggesting that the activation of phonological representations is not language specific. Less is known about developing readers. First, it is unclear whether there is automatic phonological activation during visual word recognition among children in general. Second, no empirical data exist on whether the activation of phonological representations is language specific or not in bilingual children...
November 8, 2016: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/27814344/subclinical-mastitis-occurs-frequently-in-association-with-dramatic-changes-in-inflammatory-anti-inflammatory-breast-milk-components
#6
Edouard Tuaillon, Johanes Viljoen, Pierre Dujols, Gilles Cambonie, Pierre-Alain Rubbo, Nicolas Nagot, Ruth M Bland, Stéphanie Badiou, Marie-Louise Newell, Philippe Van de Perre
BACKGROUND: Subclinical mastitis (SCM) is a frequent, but poorly characterized entity that may influence immune development of breastfed infants. Mechanisms driving the emergence of SCM and changes in immunological content of human milk during SCM remains to be explored. In this study, the breast milk environment was to describe during SCM. METHODS: One hundred ten samples of mature breast milk were collected from 44 healthy, HIV negative mothers, included in a large infant feeding intervention cohort (ANRS 1271/Vertical Transmission Study)...
November 4, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27749603/changes-in-cognitive-function-over-96-weeks-in-na%C3%A3-ve-patients-randomised-to-darunavir-ritonavir-plus-either-raltegravir-or-tenofovir-emtricitabine-a-substudy-of-the-neat001-anrs143-trial
#7
Alan Winston, Wolfgang Stöhr, Andrea Antinori, Helene Amieva, Philippe Perré, Stephane De Wit, Jacques Reynes, Mark Gompels, Antonella d'Arminio Monforte, Jose-Maria Gatell, Jesper Grarup, Anton Pozniak, Abdel Babiker, François Raffi, Laura Richert
BACKGROUND: Improvements in cognitive function are described after initiation of combination antiretroviral therapy (cART), with sparse data on differences between cART strategies. METHODS: We assessed changes in cognition, over 96 weeks, in therapy naïve HIV-positive adults randomised to darunavir/ritonavir (800/100mg once daily) with either raltegravir (400mg twice daily, Arm1) or tenofovir/emtricitabine (245/200mg once daily, Arm2). Seven cognitive tests were administered at baseline and week 96...
October 3, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27703070/cap0037-a-novel-global-regulator-of-clostridium-acetobutylicum-metabolism
#8
Ngoc-Phuong-Thao Nguyen, Sonja Linder, Stefanie K Flitsch, Bettina Schiel-Bengelsdorf, Peter Dürre, Philippe Soucaille
: An operon comprising two genes, CA_P0037 and CA_P0036, that encode proteins of unknown function that were previously shown to be highly expressed in acidogenic cells and repressed in solventogenic and alcohologenic cells is located on the pSOL1 megaplasmid of Clostridium acetobutylicum upstream of adhE2 A CA_P0037::int (189/190s) mutant in which an intron was inserted at position 189/190 in the sense strand of CA_P0037 was successfully generated by the Targetron technique. The resultant mutant showed significantly different metabolic flux patterns in acidogenic (producing mainly lactate, butyrate, and butanol) and alcohologenic (producing mainly butyrate, acetate, and lactate) chemostat cultures but not in solventogenic or batch cultures...
October 4, 2016: MBio
https://www.readbyqxmd.com/read/27692645/separation-properties-of-the-mil-125-ti-metal-organic-framework-in-high-performance-liquid-chromatography-revealing-cis-trans-selectivity
#9
Stijn Van der Perre, Anuschka Liekens, Bart Bueken, Dirk E De Vos, Gino V Baron, Joeri F M Denayer
Monodisperse MIL-125(Ti) Metal-Organic Framework crystals were synthesized and studied as stationary phase in high performance liquid chromatography (HPLC). Different pure compounds and model mixtures (including stereoisomer mixtures) were injected from which chromatographic parameters, including selectivities and resolution factors, were determined to evaluate the adsorption properties and separation performance of MIL-125(Ti) in liquid phase. The MIL-125(Ti) framework displayed a trans selectivity for cis/trans difunctionalized cyclohexane molecules with high selectivity and resolution for 1,3-dimethylcyclohexane and 4-ethylcyclohexanol...
October 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27688094/zika-virus-strains-potentially-display-different-infectious-profiles-in-human-neural-cells
#10
Yannick Simonin, Fabien Loustalot, Caroline Desmetz, Vincent Foulongne, Orianne Constant, Chantal Fournier-Wirth, Fanny Leon, Jean-Pierre Molès, Aurélien Goubaud, Jean-Marc Lemaitre, Marianne Maquart, Isabelle Leparc-Goffart, Laurence Briant, Nicolas Nagot, Philippe Van de Perre, Sara Salinas
The recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is currently found circulating in Africa. The original African strain was also suggested to be neurovirulent but its laboratory usage has been criticized due to its multiple passages. In this study, we compared the French Polynesian (Asian) ZIKV strain to an African strain isolated in Central African Republic and show a difference in infectivity and cellular response between both strains in human neural stem cells and astrocytes...
September 21, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27679613/high-nasal-carriage-rate-of-staphylococcus-aureus-containing-panton-valentine-leukocidin-and-edin-encoding-genes-in-community-and-hospital-settings-in-burkina-faso
#11
Abdoul-Salam Ouedraogo, Catherine Dunyach-Remy, Aimée Kissou, Soufiane Sanou, Armel Poda, Carole G Kyelem, Jérôme Solassol, Anne-Laure Bañuls, Philippe Van De Perre, Rasmata Ouédraogo, Hélène Jean-Pierre, Jean-Philippe Lavigne, Sylvain Godreuil
The objectives of the present study were to investigate the rate of S.aureus nasal carriage and molecular characteristics in hospital and community settings in Bobo Dioulasso, Burkina Faso. Nasal samples (n = 219) were collected from 116 healthy volunteers and 103 hospitalized patients in July and August 2014. Samples were first screened using CHROMagar Staph aureus chromogenic agar plates, and S. aureus strains were identified by mass spectrometry. Antibiotic susceptibility was tested using the disk diffusion method on Müller-Hinton agar...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27676423/circulating-3-t1am-and-3-5-t2-in-critically-ill-patients-a-cross-sectional-observational-study
#12
Lies Langouche, Ina Lehmphul, Sarah Vander Perre, Josef Koehrle, Greet Van den Berghe
BACKGROUND: Critical illness is hallmarked by low circulating T4 and T3 concentrations, in the presence of elevated rT3 and low-normal TSH, referred to as non-thyroidal illness (NTI). Thyroid hormone (TH) metabolism is substantially increased during NTI, in part explained by enhanced deiodinase 3 (D3) activity. T4- and T3-sulfate concentrations are elevated, due to suppressed D1 activity in the presence of unaltered sulfotransferase activity, and 3,3'-diiodothyronine (3,3'-T2) concentrations are normal...
September 27, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27603919/high-ifn-%C3%AE-release-and-impaired-capacity-of-multi-cytokine-secretion-in-igra-supernatants-are-associated-with-active-tuberculosis
#13
Séverine Carrère-Kremer, Pierre-Alain Rubbo, Amandine Pisoni, Sophie Bendriss, Grégory Marin, Marianne Peries, Karine Bolloré, Dominique Terru, Sylvain Godreuil, Arnaud Bourdin, Philippe Van de Perre, Edouard Tuaillon
Interferon gamma (IFN-γ) release assays (IGRAs) detect Mycobacterium tuberculosis (Mtb) infection regardless of the active (ATB) or latent (LTBI) forms of tuberculosis (TB). In this study, Mtb-specific T cell response against region of deletion 1 (RD1) antigens were explored by a microbead multiplex assay performed in T-SPOT TB assay (T-SPOT) supernatants from 35 patients with ATB and 115 patients with LTBI. T-SPOT is positive when over 7 IFN-γ secreting cells (SC)/250 000 peripheral blood mononuclear cells (PBMC) are enumerated...
2016: PloS One
https://www.readbyqxmd.com/read/27602575/morphological-characterization-and-quantification-of-the-mycelial-growth-of-the-brown-rot-fungus-postia-placenta-for-modeling-purposes
#14
Huan Du, Pin Lv, Mehdi Ayouz, Arnaud Besserer, Patrick Perré
Continuous observation was performed using confocal laser scanning microscopy to visualize the three-dimensional microscopic growth of the brown-rot fungus, Postia placenta, for seventeen days. The morphological characterization of Postia placenta was quantitatively determined, including the tip extension rate, branch angle and branching length, (hyphal length between two adjacent branch sites). A voxel method has been developed to measure the growth of the biomass. Additionally, the tip extension rate distribution, the branch angle distribution and the branching length distribution, which quantified the hyphal growth characteristics, were evaluated...
2016: PloS One
https://www.readbyqxmd.com/read/27591670/a-dual-purpose-silver-nanoparticles-biosynthesized-using-aqueous-leaf-extract-of-detarium-microcarpum-an-under-utilized-species
#15
Ayomide H Labulo, Elijah T Adesuji, Oyinade A Dedeke, Olusola S Bodede, Charles O Oseghale, Roshila Moodley, Vincent O Nyamori, Enock O Dare, Olajire A Adegoke
The need for green synthesis of emerging industrial materials has led to the biosynthesis of nanoparticles from plants to circumvent the adverse by-products of chemical synthesis. In this study, the leaf extract of Detarium mirocarpum Guill & Perr, a small tree belonging to the family Fabaceae (Legume), was used to synthesize silver nanoparticles (DAgNPs). DAgNPs were characterized using spectroscopic techniques (Ultraviolet-Visible spectroscopy and Fourier Transform Infrared spectroscopy) which showed hydroxyl and carbonyl functional groups to be responsible for their synthesis...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27477530/prior-event-rate-ratio-adjustment-for-hidden-confounding-in-observational-studies-of-treatment-effectiveness-a-pairwise-cox-likelihood-approach
#16
Nan Xuan Lin, William Edward Henley
Observational studies provide a rich source of information for assessing effectiveness of treatment interventions in many situations where it is not ethical or practical to perform randomized controlled trials. However, such studies are prone to bias from hidden (unmeasured) confounding. A promising approach to identifying and reducing the impact of unmeasured confounding is prior event rate ratio (PERR) adjustment, a quasi-experimental analytic method proposed in the context of electronic medical record database studies...
December 10, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27437558/co-occurrence-frequency-evaluated-with-large-language-corpora-boosts-semantic-priming-effects
#17
Angèle Brunellière, Laetitia Perre, ThiMai Tran, Isabelle Bonnotte
In recent decades, many computational techniques have been developed to analyze the contextual usage of words in large language corpora. The present study examined whether the co-occurrence frequency obtained from large language corpora might boost purely semantic priming effects. Two experiments were conducted: one with conscious semantic priming, the other with subliminal semantic priming. Both experiments contrasted three semantic priming contexts: an unrelated priming context and two related priming contexts with word pairs that are semantically related and that co-occur either frequently or infrequently...
July 20, 2016: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/27399077/increased-epstein-barr-virus-in-breast-milk-occurs-with-subclinical-mastitis-and-hiv-shedding
#18
Armen Sanosyan, David G Rutagwera, Jean-Pierre Molès, Karine Bollore, Marianne Peries, Chipepo Kankasa, Mwiya Mwiya, Thorkild Tylleskär, Nicolas Nagot, Philippe Van De Perre, Edouard Tuaillon
Epstein-Barr virus (EBV) in breast milk and subclinical mastitis (SCM) are both associated with human immunodeficiency virus (HIV) shedding and possibly with postnatal HIV transmission. The objective of this nested case-control study was to investigate the interplay between SCM and EBV replication in breast milk of HIV-infected mothers.The relationships between EBV deoxyribonucleic acid (DNA) shedding, HIV-1 ribonucleic acid (RNA) level, and SCM were explored in breast milk samples of Zambian mothers participating in the ANRS 12174 trial...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27389932/optimizing-the-virological-success-of-tenofovir-df-ftc-rilpivirine-in-hiv-infected-naive-and-virologically-suppressed-patients-through-strict-clinical-and-virological-selection
#19
Camille Bernaud, Lydie Khatchatourian, Audrey Rodallec, Nolwenn Hall, Philippe Perre, Marine Morrier, Solène Pineau, Thomas Jovelin, Elisabeth André-Garnier, François Raffi, Clotilde Allavena
BACKGROUND: Tenofovir DF/FTC/rilpivirine (TDF/FTC/RPV) is a single tablet regimen considered as safe and efficacious in HIV population as long as food requirements, concomitant PPI administration, and compromised antiviral activity have been carefully reviewed. We evaluated TDF/FTC/RPV in a real-life setting with focus on clinical and virological outcomes. METHODS: OCEAN II is a prospective, two-centre observational study. From September 2012 to December 2013, antiretroviral-naive patients with HIV RNA <100,000 copies/mL or wishing to switch for simplification were considered for TDF/FTC/RPV...
October 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27389400/active-chemical-fractions-of-stem-bark-extract-of-khaya-grandifoliola-c-dc-and-entada-africana-guill-et-perr-synergistically-protect-primary-rat-hepatocytes-against-paracetamol-induced-damage
#20
Frédéric Nico Njayou, Arnaud Fondjo Kouam, Brice Fredy Nemg Simo, Angèle Nkouatchoua Tchana, Paul Fewou Moundipa
BACKGROUND: Khaya grandifoliola (Meliaceae) and Entada africana (Fabaceae) are traditionally used in Bamun (a western tribe of Cameroon) traditional medicine for the treatment of liver related diseases. In this study, the synergistic hepatoprotective effect of respective active fractions of the plants were investigated against paracetamol-induced toxicity in primary cultures of rat hepatocytes. METHODS: Paracetamol conferred hepatocyte toxicity, as determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, alanine aminotransferase (ALT), superoxide dismutase (SOD), catalase (CAT) activities, malondialdehyde (MDA) and glutathione (GSH) content assays...
2016: BMC Complementary and Alternative Medicine
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