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https://www.readbyqxmd.com/read/29258652/phonemic-feature-involvement-in-lexical-access-in-grades-3-and-5-evidence-from-visual-and-auditory-lexical-decision-tasks
#1
Karinne Sauval, Laetitia Perre, Séverine Casalis
Numerous studies have evidenced the involvement of the phonological code during visual word recognition not only in skilled adult readers but also in child readers. Moreover, in skilled adult readers, visual word processing has been shown to be sensitive to phonetic details such as phonemic features (e.g., manner of articulation, place of articulation, voicing and nasality in French) which are typically involved in phonological lexicon access during speech processing. In contrast, it is not known whether and when visual word recognition is affected by phonemic features during learning to read...
December 16, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29237286/redox-sensing-under-hypochlorite-stress-and-infection-conditions-by-the-rrf2-family-repressor-hypr-in-staphylococcus-aureus
#2
Vu Van Loi, Tobias Busche, Jörg Bernhardt, Karsten Tedin, Jan Wollenhaupt, Nguyen Thi Thu Huyen, Chris Weise, Jörn Kalinowski, Markus Wahl, Marcus Fulde, Haike Antelmann
AIMS: Staphylococcus aureus is a major human pathogen and has to cope with reactive oxygen and chlorine species (ROS, RCS) during infections, which requires efficient protection mechanisms to avoid destruction. Here, we have investigated the changes in the RNA-seq transcriptome by the strong oxidant NaOCl in S. aureus USA300 to identify novel redox-sensing mechanisms that provide protection under infection conditions. RESULTS: NaOCl stress caused an oxidative stress response in S...
December 14, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29214737/efficacy-safety-and-patient-reported-outcomes-of-ledipasvir-sofosbuvir-in-ns3-4a-protease-inhibitor-experienced-individuals-with-hepatitis-c-virus-genotype-1-and-hiv-coinfection-with-and-without-cirrhosis-anrs-hc31-softrih-study
#3
E Rosenthal, C Fougerou-Leurent, A Renault, M P Carrieri, F Marcellin, R Garraffo, E Teicher, H Aumaitre, K Lacombe, F Bailly, E Billaud, S Chevaliez, S Dominguez, M A Valantin, J Reynes, A Naqvi, L Cotte, S Metivier, V Leroy, M Dupon, T Allegre, P De Truchis, V Jeantils, J Chas, D Salmon-Ceron, P Morlat, D Neau, P Perré, L Piroth, S Pol, M Bourlière, G P Pageaux, L Alric, D Zucman, P M Girard, I Poizot-Martin, Y Yazdanpanah, F Raffi, E Le Pabic, C Tual, A Pailhé, I Amri, E Bellissant, J M Molina
OBJECTIVES: Studies evaluating the efficacy and safety of the fixed-dose combination ledipasvir (LDV)/sofosbuvir (SOF) in patients coinfected with HIV-1 and hepatitis C virus (HCV) have mainly included treatment-naïve patients without cirrhosis. We aimed to evaluate the efficacy and safety of this combination in treatment-experienced patients with and without cirrhosis. METHODS: We conducted a multicentre, open-label, double-arm, nonrandomized study in patients coinfected with HIV-1 and HCV genotype 1 with and without cirrhosis, who had good viral suppression on their antiretroviral regimens...
December 7, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29197124/breast-milk-cells-trafficking-induces-microchimerism-mediated-immune-system-maturation-in-the-infant
#4
REVIEW
Jean-Pierre Molès, Edouard Tuaillon, Chipepo Kankasa, Anne-Sophie Bedin, Nicolas Nagot, Arnaud Marchant, Joann M McDermid, Philippe Van de Perre
Initiating breastfeeding within the first hour of life confers an important benefit in terms of child mortality and severe morbidity. Intestinal permeability to ingested macromolecules and immunoglobulins is limited to the first days of human life. These exchanges cease in the very early post-partum period but may increase beyond the neonatal period in response to local inflammation or introduction of a weaning food. From animal- and limited human-based observations, compelling evidence points out to breast milk cells also trafficking from mother to infant mucosal tissues and participating to the maternal microchimerism...
December 2, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29160626/film-forming-properties-of-cissus-pulpunea-guill-and-perr-and-irvingia-gabonensis-o-rorke-gums
#5
Tolulope Omolola Ajala, Hope Idemudia Olaiya, Oluwatoyin Adepeju Odeku
BACKGROUND: Natural polymers such as gums have gained attention in drug delivery systems due to their availability, compatibility and degradation under natural and physiological conditions. OBJECTIVES: The aim of the present study was to investigate the film forming properties of gums obtained from the stem of Cissus polpunea (Guill and Perr) and the seed of Irvingia gabonensis (O'Rorke). MATERIAL AND METHODS: Gums were extracted from the relevant plant parts and characterized using functional, proximate and elemental properties...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29146596/structure-and-function-of-the-leptospira-interrogans-peroxide-stress-regulator-perr-an-atypical-perr-devoid-of-a-structural-metal-binding-site
#6
Mounira Kebouchi, Frederick Saul, Raleb Taher, Annie Landier, Benedicte Beaudeau, Sarah Dubrac, Patrick Weber, Ahmed Haouz, Mathieu Picardeau, Nadia Benaroudj
Peroxide sensing is essential for bacteria survival during aerobic metabolism and host infection. Peroxide stress regulators (PerRs) are homodimeric transcriptional repressors with each monomer typically containing both structural and regulatory metal-binding sites. PerR binding to gene promoters is controlled by the presence of iron in the regulatory site, and iron-catalyzed oxidation of PerR by H2O2 leads to the dissociation of PerR from DNA. In addition to a regulatory metal, most PerRs require a structural metal for proper dimeric assembly...
November 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29143672/diagnostic-accuracy-of-serological-diagnosis-of-hepatitis-c-and-b-using-dried-blood-spot-samples-dbs-two-systematic-reviews-and-meta-analyses
#7
Berit Lange, Jennifer Cohn, Teri Roberts, Johannes Camp, Jeanne Chauffour, Nina Gummadi, Azumi Ishizaki, Anupriya Nagarathnam, Edouard Tuaillon, Philippe van de Perre, Christine Pichler, Philippa Easterbrook, Claudia M Denkinger
BACKGROUND: Dried blood spots (DBS) are a convenient tool to enable diagnostic testing for viral diseases due to transport, handling and logistical advantages over conventional venous blood sampling. A better understanding of the performance of serological testing for hepatitis C (HCV) and hepatitis B virus (HBV) from DBS is important to enable more widespread use of this sampling approach in resource limited settings, and to inform the 2017 World Health Organization (WHO) guidance on testing for HBV/HCV...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143616/diagnostic-accuracy-of-detection-and-quantification-of-hbv-dna-and-hcv-rna-using-dried-blood-spot-dbs-samples-a-systematic-review-and-meta-analysis
#8
Berit Lange, Teri Roberts, Jennifer Cohn, Jamie Greenman, Johannes Camp, Azumi Ishizaki, Luke Messac, Edouard Tuaillon, Philippe van de Perre, Christine Pichler, Claudia M Denkinger, Philippa Easterbrook
BACKGROUND: The detection and quantification of hepatitis B (HBV) DNA and hepatitis C (HCV) RNA in whole blood collected on dried blood spots (DBS) may facilitate access to diagnosis and treatment of HBV and HCV infection in resource-poor settings. We evaluated the diagnostic performance of DBS compared to venous blood samples for detection and quantification of HBV-DNA and HCV-RNA in two systematic reviews and meta-analyses on the diagnostic accuracy of HBV DNA and HCV RNA from DBS compared to venous blood samples...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29133393/sequential-induction-of-fur-regulated-genes-in-response-to-iron-limitation-in-bacillus-subtilis
#9
Hualiang Pi, John D Helmann
Bacterial cells modulate transcription in response to changes in iron availability. The ferric uptake regulator (Fur) senses intracellular iron availability and plays a central role in maintaining iron homeostasis in Bacillus subtilis Here we utilized FrvA, a high-affinity Fe(2+) efflux transporter from Listeria monocytogenes, as an inducible genetic tool to deplete intracellular iron. We then characterized the responses of the Fur, FsrA, and PerR regulons as cells transition from iron sufficiency to deficiency...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29129060/alternate-reductants-with-vb12-to-transform-c8-and-c6-perfluoroalkyl-sulfonates-limitations-and-insights-into-isomer-specific-transformation-rates-products-and-pathways
#10
Saerom Park, Chloe de Perre, Linda S Lee
Previous studies evaluating Vitamin B12 (VB12) with Ti(III)-citrate for potential use in in situ remediation of perfluorooctanesulfonate (PFOS) found that linear (L)-PFOS was unaltered. We explored if alternate reductants could overcome this limitation with a primary focus on nanoscale zerovalent zinc (nZn(0)). Transformation over time with VB12-nZn(0) was quantified at 22, 70, and 90 °C for PFOS, at 70 °C for perfluorohexanesulfonate (PFHxS), and VB12-nFe(0) and VB12-Pd(0)/nFe(0) at 70 °C for PFOS. Only branched (br-) isomers were transformed generating F(-) (no SO4(2-)) and polyfluoroalkyl intermediates/products...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29100920/4q25-microdeletion-encompassing-pitx2-a-patient-presenting-with-tetralogy-of-fallot-and-dental-anomalies-without-ocular-features
#11
P Vande Perre, C Zazo Seco, O Patat, L Bouneau, A Vigouroux, D Bourgeois, S El Hout, N Chassaing, P Calvas
Axenfeld-Rieger syndrome (ARS) is a heterogeneous clinical entity transmitted in an autosomal dominant manner. The main feature, Axenfeld-Rieger Anomaly (ARA), is a malformation of the anterior segment of the eye that can lead to glaucoma and impair vision. Extra-ocular defects have also been reported. Point mutations of FOXC1 and PITX2 are responsible for about 40% of the ARS cases. We describe the phenotype of a patient carrying a deletion encompassing the 4q25 locus containing PITX2 gene. This child presented with a congenital heart defect (Tetralogy of Fallot, TOF) and no signs of ARA...
October 31, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29076974/on-the-role-of-illness-duration-and-nutrient-restriction-in-cholestatic-alterations-that-occur-during-critical-illness
#12
Marc Jenniskens, Fabian Güiza, Marlies Oorts, Sarah Vander Perre, Sarah Derde, Thomas Dufour, Steven Thiessen, Pieter Annaert, Greet Van den Berghe, Lies Langouche
BACKGROUND AND AIMS: Elevated markers of cholestasis are common in response to critical illness, and associated with adverse outcome. The role of illness duration and of nutrient restriction on underlying molecular pathways of such cholestatic responses have not been thoroughly investigated. METHODS: In a mouse model of surgery- and sepsis-induced critical illness, molecular pathways of cholestasis were investigated up to 7 days. To assess which changes are explained by illness-induced lack of feeding, nutrient-restricted healthy mice were studied and compared with ad libitum fed healthy mice...
October 25, 2017: Shock
https://www.readbyqxmd.com/read/29050962/han-s-model-parameters-for-microalgae-grown-under-intermittent-illumination-determined-using-particle-swarm-optimization
#13
Victor Pozzobon, Patrick Perre
This work provides a model and the associated set of parameters allowing for microalgae population growth computation under intermittent lightning. Han's model is coupled with a simple microalgae growth model to yield a relationship between illumination and population growth. The model parameters were obtained by fitting a dataset available in literature using Particle Swarm Optimization method. In their work, authors grew microalgae in excess of nutrients under flashing conditions. Light/dark cycles used for these experimentations are quite close to those found in photobioreactor, i...
October 16, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29030436/a-mutator-phenotype-promoting-the-emergence-of-spontaneous-oxidative-stress-resistant-mutants-in-campylobacter-jejuni
#14
Lei Dai, Orhan Sahin, Yizhi Tang, Qijing Zhang
Campylobacter jejuni is a leading cause of foodborne illnesses worldwide. As a microaerophilic organism, C. jejuni must be able to defend against oxidative stress encountered both in the host and in the environment. How Campylobacter utilizes a mutation-based mechanism for adaptation to oxidative stress is still unknown. Here we present a previously undescribed phenotypic and genetic mechanism that promotes the emergence of oxidative stress resistant mutants. Specifically, we showed that a naturally occurring mutator phenotype, resulting from a loss of function mutation in the DNA repair enzyme MutY, increased oxidative stress resistance (OX(R)) in C...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28983276/compromised-motor-dexterity-confounds-processing-speed-task-outcomes-in-stroke-patients
#15
Essie Low, Sheila Gillard Crewther, Ben Ong, Diana Perre, Tissa Wijeratne
Most conventional measures of information processing speed require motor responses to facilitate performance. However, although not often addressed clinically, motor impairment, whether due to age or acquired brain injury, would be expected to confound the outcome measure of such tasks. The current study recruited 29 patients (20 stroke and 9 transient ischemic attack) with documented reduction in dexterity of the dominant hand, and 29 controls, to investigate the extent to which 3 commonly used processing speed measures with varying motor demands (a Visuo-Motor Reaction Time task, and the Wechsler Adult Intelligence Scale-IV Symbol Search and Coding subtests) may be measuring motor-related speed more so than cognitive speed...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28972205/breastfeeding-related-maternal-microchimerism
#16
Jean-Pierre Molès, Edouard Tuaillon, Chipepo Kankasa, Anne-Sophie Bedin, Nicolas Nagot, Arnaud Marchant, Joann M McDermid, Philippe Van de Perre
No abstract text is available yet for this article.
November 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28938859/redox-sensing-by-fe-2-in-bacterial-fur-family-metalloregulators
#17
Azul Pinochet-Barros, John D Helmann
SIGNIFICANCE: Iron is required for growth and is often redox active under cytosolic conditions. As a result of its facile redox chemistry, iron homeostasis is intricately involved with oxidative stress. Bacterial adaptation to iron limitation and oxidative stress often involves ferric uptake regulator (Fur) proteins: a diverse set of divalent cation-dependent, DNA-binding proteins that vary widely in both metal selectivity and sensitivity to metal-catalyzed oxidation. Recent Advances: Bacteria contain two Fur family metalloregulators that use ferrous iron (Fe(2+)) as their cofactor, Fur and PerR...
October 31, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28934211/differential-virulence-between-asian-and-african-lineages-of-zika-virus
#18
Yannick Simonin, Debby van Riel, Philippe Van de Perre, Barry Rockx, Sara Salinas
No abstract text is available yet for this article.
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28930136/methanol-extract-from-anogeissus-leiocarpus-dc-guill-et-perr-combretaceae-stem-bark-quenches-the-quorum-sensing-of-pseudomonas-aeruginosa-pao1
#19
Vincent Ouedraogo, Martin Kiendrebeogo
Background: Due to its extensive arsenal of virulence factors and inherent resistance to antibiotics, Pseudomonas aeruginosa is a threat particularly in immunocompromised patients. Considering the central role of quorum sensing in the production of virulence factors, inhibition of bacterial communication mechanism constitute an opportunity to attenuate pathogenicity of bacteria resistant to available antibiotics. Our study aimed to assess the anti-quorum sensing activity of Anogeissus leiocarpus, traditionally used in Burkina Faso, for the treatment of infected burn wounds...
October 6, 2016: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28922725/ameliorative-impact-of-morus-alba-leaves-aqueous-extract-against-embryonic-ophthalmic-tissue-malformation-in-streptozotocin-induced-diabetic-rats
#20
Adel M A Assiri, Mohamed E El-Beeh, Ali H Amin, Mohamed Fawzy Ramadan
BACKGROUND: Diabetes mellitus (DM) is becoming a serious threat to human health. Morus alba var. multicaulis (Perr.) Loudon (Moraceae) showed a bright future in DM therapy. OBJECTIVE: The study evaluates the antioxidant activity of Morus alba leaves aqueous extract (MLAE) and antidiabetic properties of MLAE in streptozotocin-induced diabetic rats focusing on the ameliorative effects against embryogenesis defects. MATERIALS AND METHODS: MLAE was assayed for bioactive compounds, and antiradical potential...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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