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Alice Thébaut, Antal Nemeth, Jeannie Le Mouhaër, René Scheenstra, Ulrich Baumann, Bart Koot, Fredéric Gottrand, Roderick Houwen, Laure Monard, Sylvie Lafaye de Micheaux, Dalila Habes, Emmanuel Jacquemin
OBJECTIVES: D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe to provide an orally bioavailable source of vitamin E in children with cholestasis. The aim was to analyze the safety/efficacy of Vedrop in a large group of children with chronic cholestasis. METHODS: Two hundred seventy-four children receiving Vedrop for vitamin E deficiency or for its prophylaxis were included from 7 European centers. Median age at treatment onset was 2 months and median follow-up was 11 months...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
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