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Lung cancer,meta-analysis

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https://www.readbyqxmd.com/read/27903976/prognostic-role-of-cyclin-b1-in-solid-tumors-a-meta-analysis
#1
Chenyang Ye, Ji Wang, Pin Wu, Xiaofen Li, Ying Chai
Cyclin B1 is a key mitotic cyclin in the G2-M phase transition of the cell cycle and is overexpressed in various malignant tumors. Numerous studies have reported contradictory evidences of the correlation between cyclin B1 expression and prognosis in human solid tumors. To address this discrepancy, we conducted a meta-analysis with 17 published studies searched from PubMed and Medline. Cyclin B1 overexpression was significantly associated with poor 3-year overall survival (OS) (OR = 2.05, 95% CI = 1.20 to 3...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902583/adverse-events-risk-associated-with-anti-vegfr-agents-in-the-treatment-of-advanced-nonsmall-cell-lung-cancer-a-meta-analysis
#2
Biao Gu, WenChuang Gao, HongJun Chu, Jian Gao, Zhi Fu, Hui Ding, JunJie Lv, QingQuan Wu
To perform this meta-analysis, we investigated the risk of the most clinically relevant adverse events related to antivascular endothelial growth factor receptor (VEGFR) agents in advanced nonsmall-cell lung cancer (NSCLC).A comprehensive literature search for studies published up to October 2015 was performed. Prospective randomized controlled phase II/III clinical trials that comparing therapy with or without anti-VEGFR agents for advanced NSCLC were included for analysis. Summary relative risk (RR) and 95% confidence intervals (CIs) were calculated using random effects or fixed effects according to the heterogeneity among included trials...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901493/has-aidi-injection-the-attenuation-and-synergistic-efficacy-to-gemcitabine-and-cisplatin-in-non-small-cell-lung-cancer-a-meta-analysis-of-36-randomized-controlled-trials
#3
Zheng Xiao, Chengqiong Wang, Ling Chen, Xuemei Tang, Lianhong Li, Nana Li, Jing Li, Qihai Gong, Fushan Tang, Jihong Feng, Xiaofei Li
Gemcitabine and cisplatin is the first line chemotherapy for non-small cell lung cancer with high toxicity. Aidi injection is a cantharidin and astragalu-based Chinese herbs injection in China. Has Aidi injection attenuation and synergistic efficacy to GP in NSCLC? There is lack of strong evidence to prove it. To further reveal it, we systematically evaluated all related studies. We collected all studies about Aidi injection plus GP for NSCLC in Medline, Embase, Web of Science, CNKI, VIP, Wanfang Database, CBM, CCRCT, Chi-CTR, and US-clinical trials (established to June 2015)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901246/chemotherapy-for-advanced-non-small-cell-lung-cancer-in-the-elderly-population
#4
Fábio Nasser Santos, Tiago Biachi de Castria, Marcelo Rocha Souza Cruz, Rachel Riera
BACKGROUND: Approximately 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at diagnosis. Despite this fact, these patients are underrepresented in randomized controlled trials (RCTs). As a consequence, the most appropriate regimens for these patients are controversial, and the role of single-agent or combination therapy is unclear. In this setting, a critical systematic review of RCTs in this group of patients is warranted. OBJECTIVES: To assess the effectiveness and safety of different cytotoxic chemotherapy regimens for previously untreated elderly patients with advanced (stage IIIB and IV) NSCLC...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27896575/retraction-note-to-the-efficacy-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-for-molecularly-selected-patients-with-non-small-cell-lung-cancer-a-meta-analysis-of-30-randomized-controlled-trials
#5
https://www.readbyqxmd.com/read/27893656/is-it-feasible-to-detect-epidermal-growth-factor-receptor-mutations-in-circulating-tumor-cells-in-nonsmall-cell-lung-cancer-a-meta-analysis
#6
Yafang Liu, Ze Xing, Ping Zhan, Hongbing Liu, Wei Ye, Tangfeng Lv, Yong Song
BACKGROUND: The value of circulating tumor cells (CTCs) in detecting epidermal growth factor receptor (EGFR) mutations in patients with nonsmall cell lung cancer (NSCLC) is controversial. We performed a meta-analysis to investigate the diagnostic significance of CTCs with tumor tissues as the standard control. METHODS: A systematic literature search, including papers published until November 26, 2015, was performed using PubMed, Medline, Embase, Web of Science, and the China National Knowledge Infrastructure, and the references of retrieved articles were screened...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27893423/efficacy-and-safety-of-icotinib-in-treating-non-small-cell-lung-cancer-a-systematic-evaluation-and-meta-analysis-based-on-15-studies
#7
Rong Biaoxue, Liu Hua, Gao Wenlong, Yang Shuanying
Icotinib is a new epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that developed and used in China; this work was to evaluate its efficacy and safety in treating non-small cell lung cancer (NSCLC). Clinical studies evaluating the efficacy and safety of icotinib in treating NSCLC were identified from the databases of Medline, Web of Science, Embase and Cochrance Library. Pooled efficacy and safety of icotinib were calculated through a series of predefined search strategies. A total of 15 studies with 2,304 patients were involved in this study...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27879970/mortality-hospital-days-and-expenditures-attributable-to-ambient-air-pollution-from-particulate-matter-in-israel
#8
Gary M Ginsberg, Ehud Kaliner, Itamar Grotto
BACKGROUND: Worldwide, ambient air pollution accounts for around 3.7 million deaths annually. Measuring the burden of disease is important not just for advocacy but also is a first step towards carrying out a full cost-utility analysis in order to prioritise technological interventions that are available to reduce air pollution (and subsequent morbidity and mortality) from industrial, power generating and vehicular sources. METHODS: We calculated the average national exposure to particulate matter particles less than 2...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27877216/investigating-a-correlation-between-chemoradiotherapy-schedule-parameters-and-overall-survival-in-a-real-life-ld-sclc-patient-cohort
#9
Farkhad Manapov, Chukwuka Eze, Maximilian Niyazi, Olarn Roengvoraphoj, Minglun Li, Nina-Sophie Hegemann, Guido Hildebrandt, Rainer Fietkau, Claus Belka
Background: Chemoradiotherapy (CRT) is a treatment standard in limited disease (LD) small cell lung cancer (SCLC). Currently, the timing of thoracic radiation therapy (TRT) remains the subject of randomised trials and meta-analyses. To investigate a correlation between CRT schedule parameters and overall survival (OS) in a real-life patient cohort, a temporal analysis was performed. Methods: 182 LD SCLC patients successfully treated with definitive CRT were retrospectively reviewed. TRT was applied concurrently or sequentially...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27876230/intercalated-chemotherapy-and-epidermal-growth-factor-receptor-inhibitors-for-patients-with-advanced-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#10
REVIEW
Anna La Salvia, Antonio Rossi, Domenico Galetta, Elisa Gobbini, Emmanuele De Luca, Silvia Novello, Massimo Di Maio
Randomized clinical trials (RCTs) of concurrent epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) plus chemotherapy for unselected patients with advanced non-small-cell lung cancer (NSCLC) produced negative results. Intercalated administration could avoid the reduction of chemotherapy activity due to G1 cell-cycle arrest from EGFR-TKIs. A PubMed search was performed in December 2015 and updated in February 2016. The references from the selected studies were also checked to identify additional eligible trials...
October 28, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27874106/is-leukocyte-telomere-length-related-with-lung-cancer-risk-a-meta-analysis
#11
Behrooz Karimi, Masud Yunesian, Ramin Nabizadeh, Parvin Mehdipour, Afsaneh Aghaie
BACKGROUND: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard. The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. METHODS: A systematic search was carried out using PubMed, EMBASE, and ISI before 2015...
November 22, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27867560/should-primary-tumor-be-resected-for-non-small-cell-lung-cancer-with-malignant-pleural-disease-unexpectedly-found-during-operation-a-systemic-review-and-meta-analysis
#12
Yuyang Xu, Nan Chen, Zihuai Wang, Yingyi Zhang, Jiandong Mei, Chengwu Liu, Lunxu Liu
BACKGROUND: Non-small cell lung cancer (NSCLC) with malignant pleural disease (MPD) was considered to be contraindication for surgery, but sometimes MPD was unexpectedly found intraoperatively. There was no consensus on the role of surgical intervention on the primary tumor in patients with MPD. The object of this research was to assess whether exairesis of primary tumor could prolong survival time. METHODS: A systemic research of literature was performed on the databases of PubMed, Embase and Web of Science...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27863436/chemotherapy-plus-dendritic-cells-co-cultured-with-cytokine-induced-killer-cells-versus-chemotherapy-alone-to-treat-advanced-non-small-cell-lung-cancer-a-meta-analysis
#13
Cuiling Zhou, Donglan Liu, Jie Li, Huanhuan Sun, Xiaobin Zheng, Shuncong Wang, Guobin Hong, Saradhi Mallampati, Hongliu Sun, Xiuling Zhou, Zhibin Cheng, Hongyu Zhang, Haiqing Ma
This study was aimed to investigate the efficacy and safety of the combination treatment of dendritic cells co-cultured with cytokine-induced killer cells and chemotherapy for patients with advanced non-small-cell lung cancer (NSCLC). Literatures were searched from the Cochrane Library Central, PubMed, Web of Science and EMBASE. The primary endpoint of interest was overall survival (OS), and secondary endpoints were disease control rate (DCR) and progression free survival (PFS). Finally 7 trials published between January 2005 and March 2016 met inclusion criteria and totally 610 patients were enrolled...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27858864/can-aidi-injection-restore-cellular-immunity-and-improve-clinical-efficacy-in-non-small-cell-lung-cancer-patients-treated-with-platinum-based-chemotherapy-a-meta-analysis-of-17-randomized-controlled-trials-following-the-prisma-guidelines
#14
Zheng Xiao, Chengqiong Wang, Yongping Sun, Nana Li, Jing Li, Ling Chen, Xingsheng Yao, Jie Ding, Hu Ma
BACKGROUND: Aidi injection is an adjuvant chemotherapy drug commonly used in China. Can Aidi injection restore the cellular immunity and improve the clinical efficacy in non-small-cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy? There is a lack of strong evidence to prove it. To further reveal it, we systematically evaluated all related studies. We collected all studies about the clinical efficacy and cellular immunity of Aidi injection plus platinum-based chemotherapy for NSCLC in Medline, Embase, Web of Science, China national knowledge infrastructure database (CNKI), Chinese Scientific Journals Full-Text Database (VIP), Wanfang, China biological medicine database (CBM) (established to June 2015), Cochrane Central Register of Controlled Trials (CCRCT) (June 2015), Chinese clinical trial registry, and US-clinical trials (June 2015)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855709/thoracotomy-is-better-than-thoracoscopic-lobectomy-in-the-lymph-node-dissection-of-lung-cancer-a-systematic-review-and-meta-analysis
#15
Wenxiong Zhang, Yiping Wei, Han Jiang, Jianjun Xu, Dongliang Yu
BACKGROUND: The aim of this study was to investigate which surgical method is better in lymph node (LN) dissection of lung cancer. METHODS: A comprehensive search of PubMed, Ovid MEDLINE, EMBASE, Web of Science, ScienceDirect, the Cochrane Library, Scopus, and Google Scholar was performed to identify studies comparing thoracoscopic lobectomy (video-assisted thoracic surgery (VATS) group) and thoracotomy (open group) in LN dissection. RESULTS: Twenty-nine articles met the inclusion criteria and involved 2763 patients in the VATS group and 3484 patients in the open group...
November 17, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27835601/is-there-a-benefit-of-first-or-second-line-crizotinib-in-locally-advanced-or-metastatic-anaplastic-lymphoma-kinase-positive-non-small-cell-lung-cancer-a-meta-analysis
#16
Hao Hu, Wei Qing Lin, Qian Zhu, Xiong Wen Yang, Hai Dong Wang, Yu Kang Kuang
BACKGROUND: Crizotinib show a promising efficacy in patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). However, differences in efficacy for first- and second-line crizotinib are unclear. RESULTS: The pooled overall response rate and progression-free survival were 65% and 9.38 months, respectively. In the subgroup analysis, first-line crizotinib showed a higher trend of overall response rate and longer trend of progression-free survival although there was no statistical difference between first-line and second-line crizotinib (74%, 11...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27835582/overexpression-of-b7-h3-correlates-with-aggressive-clinicopathological-characteristics-in-non-small-cell-lung-cancer
#17
Shanshan Wu, Xiangfei Zhao, Sudong Wu, Rui Du, Qi Zhu, Henghu Fang, Xinhong Zhang, Chunyang Zhang, Wei Zheng, Jihua Yang, Huasong Feng
Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial. This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis. We searched the electronic databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the impact of B7-H3 on overall survival (OS)...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27833074/the-prognostic-value-of-long-non-coding-rnas-in-non-small-cell-lung-cancer-a-meta-analysis
#18
Manni Wang, Xuelei Ma, Chenjing Zhu, Linghong Guo, Qingfang Li, Ming Liu, Jing Zhang
BACKGROUND: Reports have demonstrated the prognostic function of long non-coding RNAS (lncRNAS) in patients with cancer. However, their prognostic functions in non small cell lung cancer (NSCLC) remain controversial. We therefore performed a meta-analysis on six lncRNAs (PVT1, AFAP1-AS1, LINC01133, ANRIL, MEG3 and UCA1) to clarify their prognostic roles in NSCLC. RESULTS: Thirty-six studies involving 6267 patients with NSCLC and 34 lncRNAs were included. Of the listed lncRNAs, 20 were shown to negatively affect patients' overall survival while the high expression of 13 lncRNAs indicated better survival outcomes...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27821176/the-expression-profile-and-clinic-significance-of-the-six-family-in-non-small-cell-lung-cancer
#19
Qian Liu, Anping Li, Yijun Tian, Yu Liu, Tengfei Li, Cuntai Zhang, Jennifer D Wu, Xinwei Han, Kongming Wu
BACKGROUND: The SIX family homeobox genes have been demonstrated to be involved in the tumor initiation and progression, but their clinicopathological features and prognostic values in non-small cell lung cancer (NSCLC) have not been well defined. We analyzed relevant datasets and performed a systemic review and a meta-analysis to assess the profile of SIX family members in NSCLC and evaluate their importance as biomarkers for diagnosis and prediction of NSCLC. METHODS: This meta-analysis included 17 studies with 2358 patients...
November 8, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27818796/minimally-invasive-methods-for-staging-in-lung-cancer-systematic-review-and-meta-analysis
#20
REVIEW
Gonzalo Labarca, Carlos Aravena, Francisco Ortega, Alex Arenas, Adnan Majid, Erik Folch, Hiren J Mehta, Michael A Jantz, Sebastian Fernandez-Bussy
Introduction. Endobronchial ultrasound (EBUS) is a procedure that provides access to the mediastinal staging; however, EBUS cannot be used to stage all of the nodes in the mediastinum. In these cases, endoscopic ultrasound (EUS) is used for complete staging. Objective. To provide a synthesis of the evidence on the diagnostic performance of EBUS + EUS in patients undergoing mediastinal staging. Methods. Systematic review and meta-analysis to evaluate the diagnostic yield of EBUS + EUS compared with surgical staging...
2016: Pulmonary Medicine
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