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Lung cancer,meta-analysis

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https://www.readbyqxmd.com/read/28644424/the-indirect-efficacy-comparison-of-dna-methylation-in-sputum-for-early-screening-and-auxiliary-detection-of-lung-cancer-a-meta-analysis
#1
REVIEW
Di Liu, Hongli Peng, Qi Sun, Zhongyao Zhao, Xinwei Yu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Jiaonan Liu, Lijuan Wu, Manshu Song, Youxin Wang
BACKGROUND: DNA methylation in sputum has been an attractive candidate biomarker for the non-invasive screening and detection of lung cancer. MATERIALS AND METHODS: Databases including PubMed, Ovid, Cochrane library, Web of Science databases, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, Vip Databases and Google Scholar were searched to collect the diagnostic trials on aberrant DNA methylation in the screening and detection of lung cancer published until 1 December 2016...
June 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28644131/the-prognostic-role-of-sirt1-expression-in-solid-malignancies-a-meta-analysis
#2
Changwen Wang, Wen Yang, Fang Dong, Yawen Guo, Jie Tan, Shengnan Ruan, Tao Huang
Although many studies have discussed the association of abnormally expressed silent information regulator 1 (Sirt1) with the prognosis of patients with a variety of solid carcinomas, they failed to agree on whether excessive Sirt1 indicates a good or poor overall survival for the patients. We conducted the current meta-analysis to illustrate the prognostic value of Sirt1 in solid malignancies. Articles published before December 2016 were searched using Pubmed and Web of Science. The studies were selected for the meta-analysis based on certain criteria...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28641155/depression-and-cancer-risk-a-systematic-review-and-meta-analysis
#3
REVIEW
Y Jia, F Li, Y F Liu, J P Zhao, M M Leng, L Chen
OBJECTIVE: To assess the associations between depression and incident cancer risk. STUDY DESIGN: Systematic review and meta-analysis. METHODS: The Cochrane Library, Web of Science, MEDLINE, and PubMed databases were searched to identify studies. The quality of included studies was assessed using the Newcastle Ottawa Scale. Risk ratios (RRs) were used to measure effect size. A random-effects model was applied to synthesize the associations between depression and cancer risk...
June 19, 2017: Public Health
https://www.readbyqxmd.com/read/28640902/hepatitis-b-virus-reactivation-and-antiviral-prophylaxis-during-lung-cancer-chemotherapy-a-systematic-review-and-meta-analysis
#4
Yu-Tuan Wu, Xin Li, Zi-Li Liu, Zhou Xu, Wei Dai, Ke Zhang, Jiu-Song Wu, Bilal Arshad, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: Antiviral drugs have been recommended as prophylaxis for the reactivation of hepatitis B virus (HBV) infection in cancer patients undergoing chemotherapy. However, screening and antiviral prophylaxis for lung cancer remain controversial because of insufficient evidence. PURPOSE: In this study, we investigate the absolute risk for HBV reactivation and the prophylactic effects of antiviral drugs in hepatitis B surface antigen (HBsAg)-positive lung cancer patients during chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28636982/meta-analysis-of-incidence-and-risk-of-severe-adverse-events-and-fatal-adverse-events-with-crizotinib-monotherapy-in-patients-with-alk-positive-nsclc
#5
Qian Zhu, Hao Hu, Feng Jiang, Chang Ying Guo, Xiong Wen Yang, Xi Liu, Yu Kang Kuang
BACKGROUND: Numerous clinical trials show crizotinib has promising efficacy for anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) patients which trigger the substitution of traditional chemotherapy to be the current standard first-line treatment for these patients. Conversely, few reports systematically analyze toxicity of crizotinib. Hence, we performed a first meta-analysis to determine the risk of crizotinib-related severe adverse events (SAEs) and fatal adverse events (FAEs) in ALK positive NSCLC patients...
June 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28629590/bulky-dna-adducts-tobacco-smoking-genetic-susceptibility-and-lung-cancer-risk
#6
Armelle Munnia, Roger W Giese, Simone Polvani, Andrea Galli, Filippo Cellai, Marco E M Peluso
The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a (32)P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carcinogen exposure in tobacco smoke studies and assess the predictive value of adducts in cancer risk. Molecular data showed increased DNA adducts in respiratory tracts of smokers vs nonsmokers. Experimental studies and meta-analysis demonstrated that the relationship between adducts and carcinogens was linear at low doses, but reached steady state at high exposure, possibly due to metabolic and DNA repair pathway saturation and increased apoptosis...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28629461/cost-effectiveness-of-lung-cancer-screening-and-treatment-methods-a-systematic-review-of-systematic-reviews
#7
Farbod Ebadifard Azar, Saber Azami-Aghdash, Fatemeh Pournaghi-Azar, Alireza Mazdaki, Aziz Rezapour, Parvin Ebrahimi, Negar Yousefzadeh
BACKGROUND: Due to extensive literature in the field of lung cancer and their heterogeneous results, the aim of this study was to systematically review of systematic reviews studies which reviewed the cost-effectiveness of various lung cancer screening and treatment methods. METHODS: In this systematic review of systematic reviews study, required data were collected searching the following key words which selected from Mesh: "lung cancer", "lung oncology", "lung Carcinoma", "lung neoplasm", "lung tumors", "cost- effectiveness", "systematic review" and "Meta-analysis"...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28628562/robotic-versus-video-assisted-lobectomy-segmentectomy-for-lung-cancer-a-meta-analysis
#8
Hengrui Liang, Wenhua Liang, Lei Zhao, Difei Chen, Jianrong Zhang, Yiyin Zhang, Shiyan Tang, Jianxing He
: Objective: To compare the safety/efficacy of the robotic-assisted lobectomy/segmentectomy (RAL/S) with the video-assisted lobectomy/segmentectomy (VAL/S) for radical lung cancer resection. BACKGROUND: It remains uncertain whether the newly developed RAL/S is comparable with the VAL/S. METHODS: A comprehensive search of online databases was performed. Perioperative outcomes were synthesized. Cumulative meta-analysis was performed to evaluate the temporal trend of pooled outcomes...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28625818/quantitative-assessment-of-lung-and-bladder-cancer-risk-and-oral-exposure-to-inorganic-arsenic-meta-regression-analyses-of-epidemiological-data
#9
Heather N Lynch, Ke Zu, Erin M Kennedy, Thuy Lam, Xiaobin Liu, Daniella M Pizzurro, Christine T Loftus, Lorenz R Rhomberg
Inorganic arsenic (iAs) in drinking water varies geographically and is prevalent worldwide. While exposures in the US are generally low, there are some areas with higher levels of naturally occurring iAs (potentially >100μg/L) where residents rely on unregulated drinking water wells. Much of the evidence on the association between iAs and cancer comes from epidemiological studies conducted in South American and Asian populations. These populations have generally been exposed to much higher levels of iAs and have differing underlying characteristics, both of which make comparing them to Western populations difficult...
June 16, 2017: Environment International
https://www.readbyqxmd.com/read/28621260/meta-analysis-of-the-incidence-and-risks-of-interstitial-lung-disease-and-qtc-prolongation-in-non-small-cell-lung-cancer-patients-treated-with-alk-inhibitors
#10
Liping Lin, Juanjuan Zhao, Ning Kong, Yan He, Jiazhu Hu, Fuxi Huang, Jianjun Han, Xiaolong Cao
BACKGROUND: To conduct a systematic review and meta-analysis to assess the overall incidence and risk of interstitial lung disease (ILD) and QTc prolongation associated with anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (-TKIs) in non-small-cell lung cancer (NSCLC) patients. RESULTS: A total of 1,770 patients from 8 clinical trials were included. The incidences of high-grade ILD and QTc prolongation was 2.5% (95% CI 1.7-3.6%), and 2.8% (95% CI 1.8-4...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619829/germline-genetic-variants-and-lung-cancer-survival-in-african-americans
#11
Carissa C Jones, William S Bush, Dana C Crawford, Angela S Wenzlaff, Ann G Schwartz, John K Wiencke, Margaret R Wrensch, William J Blot, Stephen J Chanock, Eric L Grogan, Melinda C Aldrich
BACKGROUND: African Americans (AAs) have the highest lung cancer mortality in the U.S. Genome-wide association studies of germline variants influencing lung cancer survival have not yet been conducted in AAs. We examined five previously reported GWAS catalog variants and explored additional genome-wide associations among AA lung cancer cases. METHODS: Incident non-small cell lung cancer cases (N=286) in the Southern Community Cohort Study were genotyped on the Illumina HumanExome BeadChip...
June 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28619828/the-association-of-telomere-length-in-peripheral-blood-cells-with-cancer-risk-a-systematic-review-and-meta-analysis-of-prospective-studies
#12
Xia Zhang, Qian Zhao, Wei Zhu, Tao Liu, Shao-Hua Xie, Li-Xin Zhong, Yuan-Yuan Cai, Xiao-Na Li, Mei Liang, Wen Chen, Qian-Sheng Hu, Bo Zhang
The association between telomere length (TL) in peripheral blood cells and cancer risk remains inconclusive. We carried out a meta-analysis on prospective studies. The study-specific relative risk estimates were first transformed to a common comparable scale and then were pooled by a random-effects model. The dataset was composed of 13894 cases and 71672 controls from 28 studies in 25 articles. In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers (OR=1...
June 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28617920/milestone-analyses-of-immune-checkpoint-inhibitors-targeted-therapy-and-conventional-therapy-in-metastatic-non-small-cell-lung-cancer-trials-a-meta-analysis
#13
Gideon M Blumenthal, Lijun Zhang, Hui Zhang, Dickran Kazandjian, Sean Khozin, Shenghui Tang, Kirsten Goldberg, Rajeshwari Sridhara, Patricia Keegan, Richard Pazdur
Importance: Novel intermediate end points may be useful to detect signals of early activity and prioritize new therapies to treat patients with advanced malignant neoplasms, including metastatic non-small cell lung cancer (mNSCLC). Objective: To explore milestone rate, a proposed intermediate end point for immunotherapy trials. Data Sources: Trials submitted to the US Food and Drug Administration with more than 150 patients and in which the intention-to-treat population was assessed were identified...
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28616276/benefits-of-postoperative-thoracic-radiotherapy-for-small-cell-lung-cancer-subdivided-by-lymph-node-stage-a-systematic-review-and-meta-analysis
#14
Shuling Zhang, Xin Sun, Li Sun, Zhicheng Xiong, Jietao Ma, Chengbo Han
BACKGROUND: Whether postoperative thoracic radiotherapy (PORT) is beneficial for small cell lung cancer (SCLC) of different lymph node stages remains uncertain; therefore, the purpose of this meta-analysis was to explore the clinical significance of PORT for SCLC patients subdivided by lymph node status. METHODS: The PubMed, OVID, Web of SCI, EMBASE, Google Scholar, Cochrane Library, Chinese National Knowledge Infrastructure and Wanfang databases were systematically searched to identify eligible studies where SCLC patients received PORT based on lymph node stage...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28615529/association-of-three-promoter-polymorphisms-in-interleukin-10-gene-with-cancer-susceptibility-in-the-chinese-population-a-meta-analysis
#15
Ping Wang, Junling An, Yanfeng Zhu, Xuedong Wan, Hongzhen Zhang, Shoumin Xi, Sanqiang Li
Numerous studies have examined the associations of three promoter polymorphisms (-1082A/G, -819T/C and -592A/C) in IL-10 gene with cancer susceptibility in the Chinese population, but the results remain inconclusive. To gain a more precise estimation of this potential association, we conducted the current meta-analysis based on 53 articles, including 26 studies with 4,901 cases and 6,426 controls for the -1082A/G polymorphism, 33 studies with 6,717 cases and 8,550 controls for the -819T/C polymorphism, and 42 studies with 9,934 cases and 13,169 controls for the -592A/C polymorphism...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615525/casp8-652-6n-insertion-deletion-polymorphism-and-overall-cancer-risk-evidence-from-49-studies
#16
Jiarong Cai, Qingjian Ye, Suling Luo, Ze Zhuang, Kui He, Zhen-Jian Zhuo, Xiaochun Wan, Juan Cheng
The CASP8 -652 6N insertion/deletion (I/D) polymorphism reduces expression of caspase 8. We conducted a meta-analysis to clarify the relationship between this polymorphism and cancer risk. Eligible articles were retrieved from PubMed, EMBASE, CNKI, and WANFANG databases through February 2017. A total of 33 articles with 49 studies, including 33,494 cases and 36,397 controls, were analyzed. We found that the CASP8 -652 6N ins/del polymorphism was associated with decreased overall cancer risk in five genetic models [DD vs...
May 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614784/erlotinib-based-doublet-targeted-therapy-versus-erlotinib-alone-in-previously-treated-advanced-non-small-cell-lung-cancer-a-meta-analysis-from-24-randomized-controlled-trials
#17
REVIEW
Jian-Wei Gao, Ping Zhan, Xiang-Yu Qiu, Jia-Jia Jin, Tang-Feng Lv, Yong Song
BACKGROUND: To assess the efficacy profile of erlotinib-based doublet targeted therapy compared with erlotinib monotherapy for previously treated patients with advanced NSCLC, a meta-analysis was performed. PATIENTS AND METHODS: We rigorously searched PubMed, Embase, Cochrane and meeting proceedings. Phase II/III randomized trials reporting on the efficacy of erlotinib-doublet therapy versus single-agent therapy were selected. We estimated the HR for OS, PFS and the RR for ORR, DCR, 1-year SR...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28589547/preoperative-exercise-training-for-patients-with-non-small-cell-lung-cancer
#18
REVIEW
Vinicius Cavalheri, Catherine Granger
BACKGROUND: Surgical resection for early stage non-small cell lung cancer (NSCLC) offers the best chance of cure, but is associated with a risk of postoperative pulmonary complications (i.e. pneumonia (new infiltrate coupled with either fever (> 38º C) and purulent secretions, or fever and white cell count > 11,000), bronchopleural fistula, severe atelectasis that requires chest physiotherapy or bronchoscopy, and prolonged mechanical ventilation (> 48 hours)). It is currently unclear if preoperative exercise training, and the potential resultant improvement in exercise capacity, may also improve postoperative outcomes, such as the risk of developing postoperative pulmonary complications, the length of postoperative intercostal drainage, or the length of hospital stay...
June 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28587766/circulating-25-hydroxyvitamin-d-level-and-prognosis-of-lung-cancer-patients-a-systematic-review-and-meta-analysis
#19
Jian-Da Huang, Chao-Hui Dong, Sheng-Wen Shao, Tong-Jie Gu, Zhi-Lin Hu, Jun Ying, Dan-Fei Zhou, Yan-Ping Xie
BACKGROUND: Previous studies suggested a possible influence of circulating 25-hydroxyvitamin D [25(OH)D] level on the prognosis of lung cancer patients, but conflicting findings were reported. A systematic review and meta-analysis was thus conducted to comprehensively assess the influence of circulating 25(OH)D level on the prognosis of lung cancer patients. METHODS: Prospective or retrospective cohort studies assessing the influence of circulating 25(OH)D level on the prognosis of lung cancer patients were considered eligible...
June 3, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28572675/predictive-assessment-in-pharmacogenetics-of-glutathione-s-transferases-genes-on-efficacy-of-platinum-based-chemotherapy-in-non-small-cell-lung-cancer-patients
#20
Huan Ye, Meiqin Shao, Xiaohong Shi, Lifeng Wu, Bing Xu, Qiang Qu, Jian Qu
The influences of glutathione s-transferase P1, M1, and T1 variants on the efficacy of platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients were inconsistent in previous studies. Our meta-analysis enrolled 31 publications including 5712 patients and provided more convincing and reliable conclusions. Results showed that GSTP1 IIe105Val IIe/Val and Val/Val Asian patients were more likely to have better response rates compared to IIe/IIe patients (odds ratio (OR) = 1.592, 95% confidence intervals (CIs), 1...
June 1, 2017: Scientific Reports
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