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Lung cancer,meta-analysis

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https://www.readbyqxmd.com/read/29027179/association-of-dnmt3b-283t-c-polymorphism-with-risk-of-lung-and-gastric-cancer-a-case-control-study-and-a-meta-analysis
#1
Xianhong Feng, Jingdong Wang, Xiuli Gu, Jingli Zhang, Xiaolin Li, Zhi Tao, Jiebing Chen, Bifeng Chen
PURPOSE: To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis. METHODS: The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing. RESULTS: The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding...
October 12, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29025592/significantly-mutated-genes-and-regulatory-pathways-in-sclc-a-meta-analysis
#2
Varsha Sundaresan, Victor T Lin, Faming Liang, Frederic J Kaye, Reika Kawabata-Iwakawa, Kouya Shiraishi, Takashi Kohno, Jun Yokota, Lei Zhou
Small cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers and demands effective targeted therapeutic strategies. In this meta-analysis study, we aim to identify significantly mutated genes and regulatory pathways to help us better understand the progression of SCLC and to identify potential biomarkers. Besides ranking genes based on their mutation frequencies, we sought to identify statistically significant mutations in SCLC with the MutSigCV software. Our analysis identified several genes with relatively low mutation frequency, including PTEN, as highly significant (pā€‰<ā€‰0...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29025048/meta-analysis-of-occupational-exposures-in-the-rubber-manufacturing-industry-and-risk-of-cancer
#3
Mathieu Boniol, Alice Koechlin, Peter Boyle
Background: : Occupational exposures in the rubber manufacturing industry showed an increased risk of cancer and have been classified as a group 1 carcinogen, largely from studies on workers employed before 1950s. Cancer sites considered as causally associated are bladder, lung and stomach, and leukaemia. Recent studies did not report an increased risk of cancer. Methods: A meta-analysis was conducted on observational studies published until April 2016 on occupational exposures in the rubber manufacturing industry and risk of cancer...
July 26, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29023696/tumor-infiltrating-tryptase-mast-cells-predict-unfavorable-clinical-outcome-in-solid-tumors
#4
Guoming Hu, Shimin Wang, Pu Cheng
The prognostic role of tumor-infiltrating tryptase(+) mast cells in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 28 published studies with 4224 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating tryptase(+) mast cells in human solid tumors. We found that tryptase(+) mast cell infiltration significantly decreased overall survival (OS) and disease-free survival (DFS) in all types of solid tumors. In stratified analyses, tryptase(+) mast cell infiltration was significantly associated with worse OS in non-small cell lung cancer, hepatocellular carcinoma and 5-year survival in colorectal cancer...
October 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29016198/carcinogenicity-of-high-consumption-of-meat-and-lung-cancer-risk-among-non-smokers-a-comprehensive-meta-analysis
#5
Patrizia Gnagnarella, Saverio Caini, Patrick Maisonneuve, Sara Gandini
Increasing evidence suggests that high consumption of meat is linked to lung cancer but the previous meta-analyses did not properly address the role of tobacco smoking as a potential confounder. We conducted a meta-analysis to investigate the association of lung cancer, among never smokers, with consumption of various type of meat, fish, heterocyclic amines and polycyclic aromatic hydrocarbons. We performed a systematic literature search and meta-analysis, for highest versus lowest consumption and dose-response...
October 10, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28994614/meta-analysis-for-the-efficacy-of-s-1-based-regimens-as-the-first-line-treatment-in-asian-chemotherapy-naive-patients-with-advanced-non-small-cell-lung-cancer
#6
Jianxin Chen, Junhui Wang, Xilin Wu, Xiaoling Che, Yan Zou, Meiling Weng, Qian Miao, Qinhong Zheng
AIM: We performed a meta-analysis to evaluate the efficacy and safety for S-1-based regimens as the first-line treatment in Asian chemotherapy-naive patients with advanced non-small-cell lung cancer. PATIENTS & METHODS: Eligible randomized clinical trials (RCTs) were included, of which data were extracted by inclusion criteria and exclusion one. Odds ratio and hazard ratio (HR) of outcomes including objective response rate (ORR), progression-free survival (PFS), overall survival (OS) and adverse effects (AEs) were explored for the final analysis...
October 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/28985095/a-propensity-matched-analysis-of-outcomes-of-patients-with-clinical-stage-i-non-small-cell-lung-cancer-treated-surgically-or-with-stereotactic-radiotherapy-a-meta-analysis
#7
Shi-Wang Wen, Li Han, Hui-Lai Lv, Yan-Zhao Xu, Zhen-Hua Li, Ming-Bo Wang, Yong-Gang Zhu, Peng Su, Zi-Qiang Tian, Yue-Feng Zhang
OBJECTIVE: The aim of this study was to compare the efficacy between SBRT and surgery based on the Propensity-Matched Analysis. METHODS: Publications on comparison SBRT and Surgery for early stage non- small cell lung cancer (NSCLC) from 2011 to 2017 were collected. Propensity score matching was used to achieve comparable treatment hazard ratios of the overall survival (OS), local control survival (LC), regional control survival (RC), loco-regional control survival (LRC), distant control survival (DC), disease-free survival (DFS), and progression-free survival (PFS) between SBRT and Surgery...
October 6, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28977967/prognostic-and-clinicopathological-significance-of-sirt1-expression-in-nsclc-a-meta-analysis
#8
Yifei Chen, Tao Wang, Wei Wang, Jiahao Hu, Ruiting Li, Shaojun He, Jiong Yang
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The prognosis of NSCLC is extremely poor and it is urgently to find a new marker. Numerous studies have confirmed that silent mating type information regulation 2 homolog-1 (sirtuin1; SIRT1) is abnormally expressed in NSCLC. This meta-analysis was performed to investigate the prognostic and clinicopathological significance of SIRT1 in NSCLC. A total of seven eligible studies, including 6 on clinicopathological features, 7 on prognosis were identified from the databases...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977966/clinicopathological-and-prognostic-significance-of-circulating-tumor-cells-in-patients-with-lung-cancer-a-meta-analysis
#9
Tingjuan Xu, Guodong Shen, Min Cheng, Weiping Xu, Gan Shen, Shilian Hu
BACKGROUND: The prognostic significance of circulating tumor cells in patients with lung cancer is controversial. Therefore, we aimed to comprehensively and quantitatively assess the prognostic role of CTCs in patients with lung cancer. METHODS: The relevant literature was searched using PubMed, the Cochrane database and the China National Knowledge Internet database (up to June 2016). Using Review Manager 5.1.2, a meta-analysis was performed using hazard ratio (HR), odds ratio (OR) and 95% confidence interval (CI) as effect values...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977959/long-non-coding-rna-tug1-as-a-potential-prognostic-biomarker-in-human-cancers-a-meta-analysis
#10
Peng-Ju Ma, Qing-Kai Guan, Lei Meng, Nan Qin, Jia Zhao, Bao-Zhe Jin
LncRNA taurine upregulated gene 1 (TUG1) is reportedly dysregulated in various cancers. We performed this meta-analysis to clarify the usefulness of TUG1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Jan 11, 2017. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to explore the relationship between TUG1 expression and overall survival (OS). Odds ratios (ORs) were calculated to assess the association between TUG1 expression and pathological parameters...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977953/association-of-three-promoter-polymorphisms-in-interleukin-10-gene-with-cancer-susceptibility-in-the-chinese-population-a-meta-analysis
#11
Ping Wang, Junling An, Yanfeng Zhu, Xuedong Wan, Hongzhen Zhang, Shoumin Xi, Sanqiang Li
Numerous studies have examined the associations of three promoter polymorphisms (-1082A/G, -819T/C and -592A/C) in IL-10 gene with cancer susceptibility in the Chinese population, but the results remain inconclusive. To gain a more precise estimation of this potential association, we conducted the current meta-analysis based on 53 articles, including 26 studies with 4,901 cases and 6,426 controls for the -1082A/G polymorphism, 33 studies with 6,717 cases and 8,550 controls for the -819T/C polymorphism, and 42 studies with 9,934 cases and 13,169 controls for the -592A/C polymorphism...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977948/meta-analysis-comparing-the-efficacy-of-nedaplatin-based-regimens-between-squamous-cell-and-non-squamous-cell-lung-cancers
#12
Yijun Tian, Qian Liu, Kongju Wu, Qian Chu, Yuan Chen, Kongming Wu
Non-small cell lung cancer (NSCLC) consists of several subtypes, including adenocarcinoma, squamous cell lung cancer, large cell lung cancer, and other rarer types. Platinum-based regimens are currently the standard for treatment of advanced NSCLC. Nedaplatin is reportedly associated with a high response rate in squamous cell lung cancer. However, the relevant studies are small and mainly descriptive. The purpose of this meta-analysis was therefore to compare the efficacy of nedaplatin in squamous cell lung cancer with that in non-squamous cell lung cancer...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977837/expression-of-glucose-transporter-1-and-prognosis-in-non-small-cell-lung-cancer-a-pooled-analysis-of-1665-patients
#13
Zhibo Tan, Chao Yang, Xiaohan Zhang, Pingju Zheng, Weixi Shen
Glucose transporter 1 (GLUT1) plays an important role in the transport and metabolism of glucose in cancer cells. An increasing number of studies have explored the connection between GLUT1 expression and prognosis in non-small cell lung cancer (NSCLC), but the results have been controversial. Therefore, we conducted a meta-analysis to obtain a comprehensive evaluation of the prognostic value of GLUT1 in NSCLC. Relevant studies from PubMed, Embase, and Web of Science were searched. Hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) were used as the effective measures...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975084/a-phase-iii-randomized-study-comparing-a-chemotherapy-with-cisplatin-and-etoposide-to-a-etoposide-regimen-without-cisplatin-for-patients-with-extensive-small-cell-lung-cancer
#14
Thierry Berghmans, Arnaud Scherpereel, Anne-Pascale Meert, Vicente Giner, Jacques Lecomte, Jean-Jacques Lafitte, Nathalie Leclercq, Marianne Paesmans, Jean-Paul Sculier
INTRODUCTION: In a literature meta-analysis, we showed survival benefits for regimens including cisplatin [hazard ratio (HR) 0.61; 95% confidence interval (CI), 0.57-0.66] and for those including etoposide (HR 0.65; 0.61-0.69). That benefit was mainly observed when etoposide alone or in combination with cisplatin was included in the chemotherapy regimens. Our objective was to determine if chemotherapy with both drugs improves survival in comparison to a non-platinum regimen with etoposide...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28972577/genome-wide-association-study-across-european-and-african-american-ancestries-identifies-a-snp-in-dnmt3b-contributing-to-nicotine-dependence
#15
D B Hancock, Y Guo, G W Reginsson, N C Gaddis, S M Lutz, R Sherva, A Loukola, C C Minica, C A Markunas, Y Han, K A Young, D F Gudbjartsson, F Gu, D W McNeil, B Qaiser, C Glasheen, S Olson, M T Landi, P A F Madden, L A Farrer, J Vink, N L Saccone, M C Neale, H R Kranzler, J McKay, R J Hung, C I Amos, M L Marazita, D I Boomsma, T B Baker, J Gelernter, J Kaprio, N E Caporaso, T E Thorgeirsson, J E Hokanson, L J Bierut, K Stefansson, E O Johnson
Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide association study (GWAS) meta-analysis of nicotine dependence, totaling 38,602 smokers (28,677 Europeans/European Americans and 9925 African Americans) across 15 studies...
October 3, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28972007/association-between-cigar-or-pipe-smoking-and-cancer-risk-in-men-a-pooled-analysis-of-five-cohort-studies
#16
Jyoti Malhotra, Claire Borron, Neal D Freedman, Christian C Abnet, Piet A van den Brandt, Emily White, Roger L Milne, Graham G Giles, Paolo Boffetta
INTRODUCTION: Use of non-cigarette tobacco products such as cigars and pipe has been increasing even though these products entail exposure to similar carcinogens to those in cigarettes. More research is needed to explore the risk of these products to guide cancer prevention efforts. METHODS: To measure the association between cigars and/or pipe smoking, and cancer incidence in men, we performed meta-analyses of data from five prospective cohorts. Cox regression was used to evaluate the association between different aspects of cigars and pipe smoking and risk of each smoking-related cancer (head & neck, esophagus, lung, stomach, liver, pancreas, kidney, bladder) for each study...
September 28, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28969076/systematic-review-and-meta-analysis-of-the-efficacy-of-serum-neuron-specific-enolase-for-early-small-cell-lung-cancer-screening
#17
Lang Huang, Jian-Guo Zhou, Wen-Xiu Yao, Xu Tian, Shui-Ping Lv, Ting-You Zhang, Shu-Han Jin, Yu-Ju Bai, Hu Ma
We performed a pooled analysis of the efficacy of serum neuron-specific enolase (NSE) levels for early detection of small cell lung cancer (SCLC) in patients with benign lung diseases and healthy individuals. Comprehensive searches of several databases through September 2016 were conducted. The quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Ultimately, 33 studies containing 9546 samples were included in the review. Pooled sensitivity of NSE for detecting SCLC was 0...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28960263/comparison-of-the-toxicity-profile-of-pd-1-versus-pd-l1-inhibitors-in-non-small-cell-lung-cancer-a-systematic-analysis-of-the-literature
#18
Rathi N Pillai, Madhusmita Behera, Taofeek K Owonikoko, Alice O Kamphorst, Suchita Pakkala, Chandra P Belani, Fadlo R Khuri, Rafi Ahmed, Suresh S Ramalingam
BACKGROUND: Monoclonal antibodies against programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) are effective therapies in patients with non-small cell lung cancer (NSCLC). Herein, the authors performed a systematic review investigating differences in the toxicities of PD-1 and PD-L1 inhibitors. METHODS: An electronic literature search was performed of public databases (MEDLINE, Excerpta Medica dataBASE [EMBASE], and Cochrane) and conference proceedings for trials using PD-1 inhibitors (nivolumab and pembrolizumab) and PD-L1 inhibitors (atezolizumab, durvalumab, and avelumab) in patients with NSCLC...
September 28, 2017: Cancer
https://www.readbyqxmd.com/read/28953208/the-utility-of-18f-fdg-pet-ct-for-the-diagnosis-of-adrenal-metastasis-in-lung-cancer-a-prisma-compliant-meta-analysis
#19
Qiang Wu, Wuxia Luo, Yaqin Zhao, Feng Xu, Qinghua Zhou
OBJECTIVES: The aim of the present meta-analysis was to systematically evaluate the overall diagnostic accuracy of F-FDG PET/CT for the detection of adrenal metastasis in lung cancer. PATIENTS AND METHODS: A comprehensive literature search of Medline (PubMed), Embase, Web of Science, Cochrane, and China National Knowledge Infrastructure databases published through 10 January 2017 on the role of F-FDG PET/CT in evaluating adrenal mass in lung cancer patients was performed...
September 25, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28950871/lung-cancer-mortality-of-residents-living-near-petrochemical-industrial-complexes-a-meta-analysis
#20
Cheng-Kuan Lin, Huei-Yang Hung, David C Christiani, Francesco Forastiere, Ro-Ting Lin
BACKGROUND: Lung cancer, as the leading cause of cancer mortality worldwide, has been linked to environmental factors, such as air pollution. Residential exposure to petrochemicals is considered a possible cause of lung cancer for the nearby population, but results are inconsistent across previous studies. Therefore, we performed a meta-analysis to estimate the pooled risk and to identify possible factors leading to the heterogeneity among studies. METHODS: The standard process of selecting studies followed the Cochrane meta-analysis guideline of identification, screening, eligibility, and inclusion...
September 26, 2017: Environmental Health: a Global Access Science Source
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