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https://www.readbyqxmd.com/read/28920077/mimicking-the-bioactivity-of-fibroblast-growth-factor-2-using-supramolecular-nanoribbons
#1
Charles M Rubert Pérez, Zaida Álvarez, Feng Chen, Taner Aytun, Samuel I Stupp
Fibroblast growth factor (FGF-2) is a multifunctional growth factor that has pleiotropic effects in different tissues and organs. In particular, FGF-2 has a special role in angiogenesis, an important process in development, wound healing, cell survival, and differentiation. Therefore, incorporating biological agents like FGF-2 within therapeutic biomaterials is a potential strategy to create angiogenic bioactivity for the repair of damaged tissue caused by trauma or complications that arise from age and/or disease...
September 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28915140/life-threatening-massive-hemoptysis-after-cryoablation-for-atrial-fibrillation
#2
Vivek Jayaschandran, Amy N Mertens, Vishal K Patel, Bhavinkumar Dalal
A 59-year-old man developed massive hemoptysis, 1 month after undergoing cryoablation procedure for atrial fibrillation. He underwent emergent bronchoscopy that revealed massive, active bleeding with clots requiring repeated suctioning, epinephrine, and cold saline injection. The source of bleeding was identified in a follow-up bronchoscopy performed few days later-a 2×3 cm area of ulceration of the left main stem bronchus which was missed in the initial bronchoscopy owing to blood obscuring the field of vision...
September 14, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28915038/frustrated-lewis-pair-polymers-as-responsive-self-healing-gels
#3
Meng Wang, Fabio Nudelman, Rebecca Matthes, Michael Patrick Shaver
Steric bulk prevents the formation of strong bonds between Lewis acids and bases in Frustrated Lewis pairs (FLPs), where latent reactivity makes these reagents transformative in small molecule activations and metal-free catalysis. However, their use as a platform for developing materials chemistry is unexplored. Here we report a fully macromolecular FLP, built from linear copolymers that containing either a sterically encumbered Lewis base or Lewis acid as a pendant functional group. The target functional copolymers were prepared by a controlled radical copolymerization of styrene with designer boron or phosphorous containing monomers...
September 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28914046/synergistic-effect-of-polypyrrole-intercalated-graphene-for-enhanced-corrosion-protection-of-aqueous-coating-in-3-5-nacl-solution
#4
Shihui Qiu, Wei Li, Wenru Zheng, Haichao Zhao, Liping Wang
Dispersion of graphene in water and incorporation of it into waterborne resin have been rarely researched and hardly achieved owing to its hydrophobicity. Furthermore, it has largely been reported that graphene with impermeability contributed to the improved anticorrosion property. Here we show that highly concentrated graphene aqueous solution up to 5 mg/mL can be obtained by synthesizing hydrophilic polypyrrole nanocolloids as intercalators and ultrasonic vibration. Based on the π-π interaction between polypyrrole and graphene, stacked graphene sheets are exfoliated to the thickness of 3~5 layers without increasing defects...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28912363/tgf%C3%AE-transforming-growth-factor-%C3%AE-blockade-induces-a-human-like-disease-in-a-nondissecting-mouse-model-of-abdominal-aortic-aneurysm
#5
Fabien Lareyre, Marc Clément, Juliette Raffort, Stefanie Pohlod, Meghana Patel, Bruno Esposito, Leanne Master, Alison Finigan, Marie Vandestienne, Nikolaos Stergiopulos, Soraya Taleb, Bram Trachet, Ziad Mallat
OBJECTIVE: Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGFβ (transforming growth factor-β) activity-a guardian of vascular integrity and immune homeostasis-would impair vascular healing in models of nondissecting AAA and would lead to sustained aneurysmal growth until rupture. APPROACH AND RESULTS: Here, we test this hypothesis in the elastase-induced AAA model in mice...
September 14, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28910132/modified-african-ngoma-healing-ceremony-for-stress-reduction-a-pilot-study
#6
Ava LaVonne Vinesett, Riitta Rutanen Whaley, Cheryl Woods-Giscombe, Paul Dennis, Medina Johnson, Yin Li, Pline Mounzeo, Mabiba Baegne, Kenneth H Wilson
OBJECTIVE: Indigenous people's ceremonies using rhythm and dance have been used for countless generations throughout the world for healing, conflict resolution, social bonding, and spiritual experience. A previous study reported that a ceremony based on the Central African ngoma tradition was favorably received by a group of Americans. The present trial compared the effects of the modified ngoma ceremony (Ngoma) with those of mindfulness-based stress reduction (MBSR) in a randomized pilot study...
September 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28906465/low-temperature-self-healing-of-a-microcapsule-type-protective-coating
#7
Dong-Min Kim, Yu-Jin Cho, Ju-Young Choi, Beom-Jun Kim, Seung-Won Jin, Chan-Moon Chung
Low-temperature self-healing capabilities are essential for self-healing materials exposed to cold environments. Although low-temperature self-healing concepts have been proposed, there has been no report of a microcapsule-type low-temperature self-healing system wherein the healing ability was demonstrated at low temperature. In this work, low-temperature self-healing of a microcapsule-type protective coating was demonstrated. This system employed silanol-terminated polydimethylsiloxane (STP) as a healing agent and dibutyltin dilaurate (DD) as a catalyst...
September 14, 2017: Materials
https://www.readbyqxmd.com/read/28904038/facilitated-access-to-an-integrated-model-of-care-for-arthritis-in-an-urban-aboriginal-population
#8
Cheryl Barnabe, Stacy Lockerbie, Elizabeth Erasmus, Lynden Crowshoe
OBJECTIVE: To evaluate a model of care to improve arthritis detection and treatment in an urban Aboriginal population. DESIGN: Cohort study. SETTING: The Elbow River Healing Lodge in Calgary, Alta. PARTICIPANTS: A total of 26 participants with noninflammatory arthritis and 12 with inflammatory arthritis. INTERVENTION: A monthly rheumatology clinic was embedded in the primary health care service and received referrals from primary care providers and allied health care professionals, or self-referrals...
September 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28903998/shape-form-function-and-leishmania-pathogenicity-from-textbook-descriptions-to-biological-understanding
#9
REVIEW
Jack Sunter, Keith Gull
The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The evolutionary pressure associated with establishing and maintaining an infection and transmission to vector or host has shaped parasite morphology. However, there is not a 'one size fits all' morphological solution to these different pressures, and parasites exhibit a range of different morphologies, reflecting the diversity of their complex life cycles. In this review, we will focus on the shape and form of Leishmania spp...
September 2017: Open Biology
https://www.readbyqxmd.com/read/28903969/healing-journey-a-qualitative-analysis-of-the-healing-experiences-of-americans-suffering-from-trauma-and-illness
#10
John Glenn Scott, Sara L Warber, Paul Dieppe, David Jones, Kurt C Stange
OBJECTIVES: To elucidate pathways to healing for people having suffered injury to the integrity of their function as a human being. METHODS: A team of physician-analysts conducted thematic analyses of in-depth interviews of 23 patients who experienced healing, as identified by six primary care physicians purposefully selected as exemplary healers. RESULTS: People in the sample experienced healing journeys that spanned a spectrum from overcoming unspeakable trauma and then becoming healers themselves to everyday heroes functioning well despite ongoing serious health challenges...
September 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28902235/trends-in-restorative-composites-research-what-is-in-the-future
#11
Mariel Soeiro Maas, Yvette Alania, Livia Camargo Natale, Marcela Charantola Rodrigues, David Christopher Watts, Roberto Ruggiero Braga
Clinical trials have identified secondary caries and bulk fracture as the main causes for composite restoration failure. As a measure to avoid frequent reinterventions for restoration replacement, composites with some sort of defense mechanism against biofilm formation and demineralization, as well as materials with lower susceptibility to crack propagation are necessary. Also, the restorative procedure with composites are very time-consuming and technically demanding, particularly concerning the application of the adhesive system...
August 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28901139/an-injectable-and-self-healing-thermo-sensitive-magnetic-hydrogel-for-asynchronous-control-release-of-doxorubicin-and-docetaxel-to-treat-triple-negative-breast-cancer
#12
Wensheng Xie, Qin Gao, Zhenhu Guo, Dan Wang, Fei Gao, Xiu-Mei Wang, Yen Wei, Lingyun Zhao
Integration of two or more drugs in a multi-agent delivery system has been considered to have profound impacts on both in vitro and in vivo cancer treatment due to their efficient synergistic effect. This study presents a cheap and simple chitosan hydrogel crosslinked with telechelic difunctional poly (ethylene glycol) (DF-PEG-DF) for synthesis of an injectable and self-healing thermo-sensitive dual-drug-loaded magnetic hydrogel (DDMH), which contains both doxorubicin (DOX) and docetaxel (DTX) for chemotherapy, and iron oxide for magnetic hyperthermia induced stimuli responsive drug release...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28900729/microbial-healing-of-cracks-in-concrete-a-review
#13
REVIEW
Sumit Joshi, Shweta Goyal, Abhijit Mukherjee, M Sudhakara Reddy
Concrete is the most widely used construction material of the world and maintaining concrete structures from premature deterioration is proving to be a great challenge. Early age formation of micro-cracking in concrete structure severely affects the serviceability leading to high cost of maintenance. Apart from conventional methods of repairing cracks with sealants or treating the concrete with adhesive chemicals to prevent the cracks from widening, a microbial crack-healing approach has shown promising results...
September 12, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28900125/mergeable-nervous-systems-for-robots
#14
Nithin Mathews, Anders Lyhne Christensen, Rehan O'Grady, Francesco Mondada, Marco Dorigo
Robots have the potential to display a higher degree of lifetime morphological adaptation than natural organisms. By adopting a modular approach, robots with different capabilities, shapes, and sizes could, in theory, construct and reconfigure themselves as required. However, current modular robots have only been able to display a limited range of hardwired behaviors because they rely solely on distributed control. Here, we present robots whose bodies and control systems can merge to form entirely new robots that retain full sensorimotor control...
September 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28895293/photoactuation-healing-of-%C3%AE-feooh-g-c3-n4-catalyst-for-efficient-and-stable-activation-of-persulfate
#15
Gong Zhang, Zhang Wu, Huijuan Liu, Qinghua Ji, Jiuhui Qu, Jinghong Li
Inspired by living systems, the construction of smart devices that can self-heal in response to structural damage is a promising technology for maintaining the high activity and stability of catalysts during heterocatalytic reactions. Here this study demonstrates an ingenious platform that enabled efficient persulfate (PS) activation for contaminant degradation via integrating a catalyst with photoactuation regeneration. Under irradiation, it is unambiguously confirmed that the collective properties of a tailored FeOOH@C3 N4 catalyst permit interfacial photoexcited electron transport from the photocatalyst substrate to needle-shaped FeOOH...
September 12, 2017: Small
https://www.readbyqxmd.com/read/28894637/epidermal-stem-cells-in-skin-wound-healing
#16
REVIEW
Yuanyuan Li, Jamie Zhang, Jiping Yue, Xuewen Gou, Xiaoyang Wu
Significance: Skin serves as a protective barrier for mammals. Epidermal stem cells are responsible for maintaining skin homeostasis. When cutaneous injuries occur, skin homeostasis and integrity are damaged, leading to dire consequences such as acute, chronic, or infected wounds. Skin wound healing is an intrinsic self-saving chain reaction, which is crucial to facilitating the replacement of damaged or lost tissue. Recent Advances: An immense amount of research has uncovered the underlying mechanisms behind the complex and highly regulated wound healing process...
September 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28894272/t-cell-tolerance-and-exhaustion-in-the-clearance-of-echinococcus-multilocularis-role-of-inoculum-size-in-a-quantitative-hepatic-experimental-model
#17
Chuanshan Zhang, Yingmei Shao, Shuting Yang, Xiaojuan Bi, Liang Li, Hui Wang, Ning Yang, Zhide Li, Cheng Sun, Liang Li, Guodong Lü, Tuerganaili Aji, Dominique A Vuitton, Renyong Lin, Hao Wen
The local immune mechanisms responsible for either self-healing or sustained chronic infection are not clear, in the development of E. multilocularis larvae. Here, we developed a suitable experimental model that mimics naturally infected livers, according to the parasite load. We demonstrated that local cellular immunity and fibrogenesis are actually protective and fully able to limit metacestode growth in the liver of low or medium dose-infected mice (LDG or MDG), or even to clear it, while impairment of cellular immunity is followed by a more rapid and severe course of the disease in high dose-infected mice (HDG)...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893069/silicone-oil-swelling-slippery-surfaces-based-on-mussel-inspired-magnetic-nanoparticles-with-multiple-self-healing-mechanisms
#18
Biyu Jin, Mingzhu Liu, Qinghua Zhang, Xiaoli Zhan, Fengqiu Chen
In this work, a novel substrate building block, magnetic Fe3O4 nanoparticles (MNPs) armed with dopamine molecules were developed via mussel-inspired metal-coordination bonds. Combined with glycidyl methacrylate, polydimethylsiloxane (PDMS) and diethylenetriamine (DETA), the original silicone oil swelling SLIPS (SPG-MNP) owning ability to heal the matrix itself were first prepared by reversible coordinate bonds and strong covalent bonds crosslinking process. The matrix mechanical characteristics and surface physicochemical properties were also systematically investigated...
September 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28893068/wetting-and-coalescence-of-drops-of-self-healing-agents-on-electrospun-nanofiber-mats
#19
Seongpil An, Yong Il Kim, Minwook Lee, Alexander L Yarin, Sam Sukgoo Yoon
Here we study experimentally behavior of liquid healing agents released in vascular core-shell nanofiber mats used in self-healing engineered materials. It is shown that wettability-driven spreading of liquid drops is accompanied by the imbibition into the nanofiber matrix and its laws deviate from those know for spreading on intact surface. We also explore coalescence of the released drops on nanofiber mats, in particular, coalescence of drops of resin monomer and cure important for self-healing. The coalescence process is also affected by the imbibition into the pores of an underlying nanofiber mat...
September 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28891636/cuaac-based-click-chemistry-in-self-healing-polymers
#20
Diana Döhler, Philipp Michael, Wolfgang H Binder
Click chemistry has emerged as a significant tool for materials science, organic chemistry, and bioscience. Based on the initial concept of Barry Sharpless in 2001, the copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC) reaction has triggered a plethora of chemical concepts for linking molecules and building blocks under ambient conditions, forming the basis for applications in autonomous cross-linking materials. Self-healing systems on the other hand are often based on mild cross-linking chemistries that are able to react either autonomously or upon an external trigger...
September 11, 2017: Accounts of Chemical Research
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