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https://www.readbyqxmd.com/read/28640996/a-polyoxometalate-based-radiosensitization-platform-for-treating-hypoxic-tumor-by-attenuating-radio-resistance-and-enhancing-radiation-response
#1
Yuan Yong, Chunfang Zhang, Zhanjun Gu, Jiangfeng Du, Zhao Guo, Xinghua Dong, Jiani Xie, Guangjin Zhang, Xiangfeng Liu, Yuliang Zhao
Radioresistance is one of the undesirable impediments in hypoxia tumor, which sharply diminishes therapeutic effectiveness of radiotherapy and eventually results in the failure of their treatments. An attractive strategy for attenuating radioresistance is developing an ideal radiosensitization system with admirable radiosensitization capacity to attenuate tumor hypoxia and reinforce radiotherapy response in hypoxia tumor. Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radiosensitization system for simultanous extrinsic and intrinsic radiosensitization, by generating overabundance cytotoxic reactive oxygen species (ROS) using high energy X-ray stimulation and mediating the hypoxia-inducible factor-1a (HIF-1a) siRNA to down-regulate HIF-1α expression and suppress the broken double-stranded DNA self-healing...
June 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28636347/the-structure-and-dynamics-of-alginate-gels-crosslinked-by-polyvalent-ions-probed-via-solid-state-nmr-spectroscopy
#2
Jiří Brus, Martina Urbanová, Jiri Czernek, Miroslava Pavelkova, Katerina Kubova, Jakub Vyslouzil, Sabina Abbrent, Rafal Konefal, Jiri Horsky, David Vetchy, Jan Vysloužil, Pavel Kulich
Alginate gels are an outstanding biomaterial widely applicable in tissue engineering, medicine, and pharmacy for cell transplantation, wound healing and efficient bioactive agent delivery, respectively. This contribution provides new and comprehensive insight into the atomic-resolution structure and dynamics of polyvalent ion-crosslinked alginate gels in microbead formulations. By applying various advanced solid-state NMR (ssNMR) spectroscopy techniques, we verified the homogenous distribution of the crosslinking ions in the alginate gels and the high degree of ion exchange...
June 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28635550/peptide-grafted-and-self-assembled-poly-%C3%AE-glutamic-acid-phenylalanine-nanoparticles-targeting-camptothecin-to-glioma
#3
Hitesh Kulhari, Srinivasa R Telukutla, Deep Pooja, Ravi Shukla, Ramakrishna Sistla, Vipul Bansal, David J Adams
AIM: To synthesize cRGDfK peptide conjugated poly(γ-glutamic acid)-phenylalanine nanoparticles to improve the therapeutic efficacy of camptothecin (CPT) against glioblastoma multiforme. METHODS: Peptide-conjugated, drug-loaded nanoparticles (cRGDfK-conjugated camptothecin-loaded PGA-PA nanoparticles [RCPN]) were prepared and physico-chemically characterized using different techniques. Nanoparticles were evaluated for in vitro anticancer activity, cellular uptake, induction of apoptosis and wound healing cell migration against U87MG human glioblastoma cells...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28633772/omnidirectional-internal-fixation-by-double-approaches-for-treating-r%C3%A3-edi-allg%C3%A3-wer-type-iii-pilon-fractures
#4
Chong-Hua Dai, Jun Sun, Kun-Quan Chen, Hui-Bo Zhang
In the present study, we explored the effectiveness and complications of omnidirectional internal fixation using a double approach for treating Rüedi-Allgöwer type III pilon fractures. A retrospective analysis was performed of 19 cases of Rüedi-Allgöwer type III unilateral closed pilon fracture. With preoperative preparation and correct surgical timing, the reduction was performed using anteromedial and posterolateral approaches, and the fracture fragments were fixed by omnidirectional internal fixation...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28632985/healable-reconfigurable-reprocessable-thermoset-shape-memory-polymer-with-highly-tunable-topological-rearrangement-kinetics
#5
Zizheng Fang, Ning Zheng, Qian Zhao, Tao Xie
The unique capability of topological rearrangement for dynamic covalent polymer networks has enabled various unusual properties (self-healing, solid-state plasticity, and reprocessability) that are not found in conventional thermosets. Achieving these properties in one network in a synergetic fashion can open up new opportunities for shape memory polymer. To accomplish such a goal, the freedom to tune topological rearrangement kinetics is critical. This is, however, challenging to achieve. In this work, two sets of dynamic bonds (urethane and hindered urea) are incorporated into a hybrid network for synthesizing shape memory poly(urea-urethane)...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28628124/emergence-of-an-enslaved-phononic-bandgap-in-a-non-equilibrium-pseudo-crystal
#6
Nicolas Bachelard, Chad Ropp, Marc Dubois, Rongkuo Zhao, Yuan Wang, Xiang Zhang
Material systems that reside far from thermodynamic equilibrium have the potential to exhibit dynamic properties and behaviours resembling those of living organisms. Here we realize a non-equilibrium material characterized by a bandgap whose edge is enslaved to the wavelength of an external coherent drive. The structure dynamically self-assembles into an unconventional pseudo-crystal geometry that equally distributes momentum across elements. The emergent bandgap is bestowed with lifelike properties, such as the ability to self-heal to perturbations and adapt to sudden changes in the drive...
June 19, 2017: Nature Materials
https://www.readbyqxmd.com/read/28622540/scattering-of-airy-elastic-sheets-by-a-cylindrical-cavity-in-a-solid
#7
F G Mitri
The prediction of the elastic scattering by voids (and cracks) in materials is an important process in structural health monitoring, phononic crystals, metamaterials and non-destructive evaluation/imaging to name a few examples. Earlier analytical theories and numerical computations considered the elastic scattering by voids in plane waves of infinite extent. However, current research suggesting the use of (limited-diffracting, accelerating and self-healing) Airy acoustical-sheet beams for non-destructive evaluation or imaging applications in elastic solids requires the development of an improved analytical formalism to predict the scattering efficiency used as a priori information in quantitative material characterization...
June 8, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28621834/from-intricate-to-integrated-biofabrication-of-articulating-joints
#8
Wilhelmina Margaretha Groen, Paweena Diloksumpan, Paul René van Weeren, Riccardo Levato, Jos Malda
Articulating joints owe their function to the specialized architecture and the complex interplay between multiple tissues including cartilage, bone and synovium. Especially the cartilage component has limited self-healing capacity and damage often leads to the onset of osteoarthritis, eventually resulting in failure of the joint as an organ. Although in its infancy, biofabrication has emerged as a promising technology to reproduce the intricate organization of the joint, thus enabling the introduction of novel surgical treatments, regenerative therapies, and new sets of tools to enhance our understanding of joint physiology and pathology...
June 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28619306/management-of-viral-oral-ulcers-in-children-using-chinese-herbal-medicine-a-report-of-two-cases
#9
Yi-Chiao Lee, Ting-Hao Wang, Shih-Yu Chen, Hsiang-Ling Lin, Ming-Yen Tsai
OBJECTIVE: Viral oral ulcers are common presentations in pediatric clinics. Although self-limiting, painful ulcerative lesions and inflamed mucosa can decrease oral intake and lead to dehydration. Despite the widespread use of Chinese herbal medicine (CHM) for pediatric upper respiratory disease in Taiwan, there is little evidence for its effectiveness as an antipyretic or in aiding ulcer healing for children with viral oral ulcers. We report two cases of children who presented with viral oral ulcers to illustrate the potential efficacy of CHM treatment in recovery from herpangina (HA) and herpetic gingivostomatitis (HGS)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28618507/contractile-actuation-and-dynamical-gel-assembly-of-paramagnetic-filaments-in-fast-precessing-fields
#10
Joshua M Dempster, Pablo Vázquez-Montejo, Monica Olvera de la Cruz
Flexible superparamagnetic filaments are studied under the influence of fast precessing magnetic fields using simulations and a continuum approximation analysis. We find that individual filaments can be made to exert controllable tensile forces along the precession axis. These forces are exploited for microscopic actuation. In bulk, the filaments can be rapidly assembled into different configurations whose material properties depend on the field parameters. The precession frequency affects filament aggregation and conformation by changing the net torques on the filament ends...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28616411/identification-of-etiologic-agents-of-cutaneous-leishmaniasis-in-palpebral-position-followed-by-effective-therapy
#11
Sedigheh Saberi, Reza Arjmand, Ali Khamesipour, Mohammad Ali Nilforoushzadeh, Shaghayegh Sayareh, Seyed Hossein Hejazi
CONTEXT: Cutaneous Leishmaniasis (CL) is a self-healing lesion but prevention of complications and involvement of vital organs such as palpebra requires proper treatment. AIMS: The main objectives were to detect agents of CL in palpebral region and estimate the proportion of palpebral lesion also possible complications among CL patients in a zoonotic CL endemic area. SETTINGS AND DESIGN: The study was performed from April 2012 to March 2013 in a total of 1613 CL suspected patients by interview and physically exam...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28607929/treatment-of-cervical-artery-dissection-antithrombotics-thrombolysis-and-endovascular-therapy
#12
REVIEW
Jing Peng, Zunjing Liu, Chunxia Luo, Lin Chen, Xianhua Hou, Li Xiao, Zhenhua Zhou
Cervical artery dissection (CAD) is an important cause of stroke for young patients, accounting for 5-22% of strokes in patients <45 years of age, which presents not only a great burden to the stroke victims but also a financial burden to the family and society. Because CAD can lead to different clinical lesions, including neuropathy, acute ischemic stroke, and subarachnoid hemorrhage, and is an arterial dissection with a self-healing tendency, the treatment options depend on the clinical manifestations...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28606930/foxn1-transcription-factor-in-epithelial-growth-and-wound-healing
#13
Anna I Grabowska, Tomasz Wilanowski
FOXN1 is a pro-differentiation transcription factor in the skin epithelium. Recently it has also emerged as an important player in controlling skin wound healing process as it actively participates in reepithelialization and is thought to be responsible for the scar formation. FOXN1-positivity is also a feature of pigmented keratinocytes, including nevi, and FOXN1 is an attribute of benign epithelial tumors. Lack of FOXN1 favors skin regeneration process which is displayed by nude mice pointing to FOXN1 as a "switch" between regeneration vs...
June 12, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28599118/sensory-metrics-of-neuromechanical-trust
#14
William Softky, Criscillia Benford
Today digital sources supply a historically unprecedented component of human sensorimotor data, the consumption of which is correlated with poorly understood maladies such as Internet addiction disorder and Internet gaming disorder. Because both natural and digital sensorimotor data share common mathematical descriptions, one can quantify our informational sensorimotor needs using the signal processing metrics of entropy, noise, dimensionality, continuity, latency, and bandwidth. Such metrics describe in neutral terms the informational diet human brains require to self-calibrate, allowing individuals to maintain trusting relationships...
June 9, 2017: Neural Computation
https://www.readbyqxmd.com/read/28596334/self-repairing-cells-how-single-cells-heal-membrane-ruptures-and-restore-lost-structures
#15
REVIEW
Sindy K Y Tang, Wallace F Marshall
Many organisms and tissues display the ability to heal and regenerate as needed for normal physiology and as a result of pathogenesis. However, these repair activities can also be observed at the single-cell level. The physical and molecular mechanisms by which a cell can heal membrane ruptures and rebuild damaged or missing cellular structures remain poorly understood. This Review presents current understanding in wound healing and regeneration as two distinct aspects of cellular self-repair by examining a few model organisms that have displayed robust repair capacity, including Xenopus oocytes, Chlamydomonas, and Stentor coeruleus Although many open questions remain, elucidating how cells repair themselves is important for our mechanistic understanding of cell biology...
June 9, 2017: Science
https://www.readbyqxmd.com/read/28595446/life-perceptions-of-patients-receiving-palliative-care-and-experiencing-psycho-social-spiritual-healing
#16
Lingsheng Li, Danetta H Sloan, Ambereen K Mehta, Gordon Willis, Meaghann S Weaver, Ann C Berger
BACKGROUND: It is important to identify, from the patients' perspectives, the different factors that contribute toward psycho-social-spiritual healing. METHODS: This was a qualitative study that took place at a large research center, an underserved clinic, and a community hospital. We used a needs assessment questionnaire and open-ended questions to assess the constituents of psycho-social-spiritual healing: (I) how previous life experiences affected patients' present situations in dealing with their illnesses; (II) barriers to palliative care, and (III) benefits of palliative care...
June 3, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28595441/healing-spirituality-and-integrative-medicine
#17
David M Steinhorn, Jana Din, Angela Johnson
Spirituality plays a prominent role in the lives of most palliative patients whether or not they formally adhere to a specific religion and belief. As a result, the palliative care team is frequently called upon to support families who are experiencing their "dark night of the soul" and struggling to make sense of their lives during a healthcare crisis. While conventional religious practices provide a source of comfort and guidance for many of our patients, a significant number of our patients do not have a strong religious community to which to turn...
May 22, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28590066/the-roles-of-signaling-pathways-in-bone-repair-and-regeneration
#18
REVIEW
Maryam Majidinia, Bahman Yousefi
Regenerative medicine has sparked interest in potential strategies for bone repair. Bone defects are widespread and could be caused by trauma, congenital malformations, infections, and surgery. Although bone has a large self-healing capacity, some defects or fractures are too big to regenerate. To regenerate bone structures which can be used for treatment of patients, bone growth must be induced by a number of bioactive implantable materials, cell types and intracellular and extracellular molecular signaling pathways...
June 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28583902/ph-responsive-self-healing-injectable-hydrogel-based-on-n-carboxyethyl-chitosan-for-hepatocellular-carcinoma-therapy
#19
Jin Qu, Xin Zhao, Peter X Ma, Baolin Guo
Injectable hydrogels with pH-responsiveness and self-healing ability have great potential for anti-cancer drug delivery. Herein, we developed a series of polysaccharide-based self-healing hydrogels with pH-sensitivity as drug delivery vehicles for hepatocellular carcinoma therapy. The hydrogels were prepared by using N-carboxyethyl chitosan (CEC) synthesized via Michael reaction in aqueous solution and dibenzaldehyde-terminated poly(ethylene glycol) (PEGDA). Doxorubicin (Dox), as a model of water-soluble small molecule anti-cancer drug was encapsulated into the hydrogel in situ...
June 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28581212/glial-cell-derived-neurotrophic-factor-promotes-dental-pulp-stem-cell-migration
#20
Nan Xiao, Wei Ye Yu, Dawei Liu
Preserving the vitality of the teeth is critical in maintaining the function and esthetics of teeth during dental treatment. Dental pulp stem cells (DPSCs) are mesenchymal cells that are demonstrated to possess stem cell properties, such as self-renewal, proliferation and pluripotency. DPSCs can be obtained through non-invasive procedure from the dental pulp and become potential resources for tissue regeneration. Neurotrophic factors are known to promote survival and growth of neurons. In the present study, we examined the expression of the glial cell derived neurotrophic factor (GDNF) family ligands and receptors, and characterized the intracellular localization of them in DPSCs...
June 5, 2017: Journal of Tissue Engineering and Regenerative Medicine
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