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https://www.readbyqxmd.com/read/29028369/toll-like-receptors-significance-ligands-signaling-pathways-and-functions-in-mammals
#1
Mallenahally Kusha Vidya, V Girish Kumar, Veerasamy Sejian, Madiajagan Bagath, Govindan Krishnan, Raghavendra Bhatta
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling immune functions with emphasis on their significance, function, regulation and expression patterns. The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. These paralogs are located on cell surfaces or within endosomes. The TLRs are found to be functionally involved in the recognition of self and non-self-antigens, maturation of DCs and initiation of antigen-specific adaptive immune responses as they bridge the innate and adaptive immunity...
October 13, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/29028050/performance-optimization-of-pm-16qam-transmission-system-enabled-by-real-time-self-adaptive-coding
#2
Zhen Qu, Yao Li, Weiyang Mo, Mingwei Yang, Shengxiang Zhu, Daniel C Kilper, Ivan B Djordjevic
We experimentally demonstrate self-adaptive coded 5×100  Gb/s WDM polarization multiplexed 16 quadrature amplitude modulation transmission over a 100 km fiber link, which is enabled by a real-time control plane. The real-time optical signal-to-noise ratio (OSNR) is measured using an optical performance monitoring device. The OSNR measurement is processed and fed back using control plane logic and messaging to the transmitter side for code adaptation, where the binary data are adaptively encoded with three types of low-density parity-check (LDPC) codes with code rates of 0...
October 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29027226/efferocytosis-of-dying-cells-differentially-modulate-immunological-outcomes-in-tumor-microenvironment
#3
REVIEW
Sushil Kumar, David Calianese, Raymond B Birge
Programmed cell death (apoptosis) is an integral part of tissue homeostasis in complex organisms, allowing for tissue turnover, repair, and renewal while simultaneously inhibiting the release of self antigens and danger signals from apoptotic cell-derived constituents that can result in immune activation, inflammation, and autoimmunity. Unlike cells in culture, the physiological fate of cells that die by apoptosis in vivo is their rapid recognition and engulfment by phagocytic cells (a process called efferocytosis)...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29026488/a-longitudinal-study-on-the-effects-of-negative-rearing-experiences-on-adolescents-social-withdrawal-and-aggression
#4
Kyung-Suk Lee, Ok-Joo Choi, Joon-Ho Kim
BACKGROUND: Children who have experienced negative rearing behaviors show a lack of self-confidence due to emotional instability and are reserved in interpersonal relationships. This can lead to failure in social adaptation and a high risk of depression, suicide, criminal acts, and anti-social behaviors. Therefore, this study aims to analyze the effects of experiencing negative parental rearing behaviors, such as neglect and abuse, on adolescents' social withdrawal and aggression, by utilizing multivariate latent growth models...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29026438/mental-health-assessments-in-refugees-and-asylum-seekers-evaluation-of-a-tablet-assisted-screening-software
#5
Naser Morina, Simon M Ewers, Sandra Passardi, Ulrich Schnyder, Christine Knaevelsrud, Julia Müller, Richard A Bryant, Angela Nickerson, Matthis Schick
BACKGROUND: Mental health problems resulting from persecution and forced migration are very common among refugees and asylum seekers and evolve into a major public health challenge in hosting societies. Language barriers often prevent timely access to appropriate health care, leading to chronic trajectories and abortive social integration. Tools for multilingual screening and assessment could be of great benefit for this particularly vulnerable population as well as for policy makers...
2017: Conflict and Health
https://www.readbyqxmd.com/read/29025414/hiv-infected-men-who-have-sex-with-men-in-israel-knowledge-attitudes-and-sexual-behavior
#6
Zohar Mor, Dan Turner, Yuval Livnat, Itzchak Levy
BACKGROUND: HIV-infected (HIVI) men who have sex with men (MSM) may transmit HIV to their sero-discordant sex partner/s. This study assesses the knowledge, attitudes and sex-practices of Israeli HIVI-MSM. METHODS: This cross-sectional study compared HIVI-MSM to self-reported HIV-uninfected (HIVU) MSM by using anonymous questionnaires that were distributed in AIDS-treatment centers and gay-related internet-sites in 2015. Unprotected anal intercourse (UAI) in the last 6 months was the outcome variable...
October 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29024921/highly-sensitive-and-selective-sensor-for-sunset-yellow-based-on-molecularly-imprinted-polydopamine-coated-multi-walled-carbon-nanotubes
#7
Zheng-Zhi Yin, Shu-Wen Cheng, Li-Bin Xu, Hong-Ying Liu, Kai Huang, Lei Li, Yun-Yun Zhai, Yan-Bo Zeng, Hai-Qing Liu, Yong Shao, Zu-Lei Zhang, Yi-Xia Lu
Polydopamine (PDA) can be formed by monomeric self-polymerization in water. This convenient behavior was exploited to prepare a molecularly imprinted polymer (MIP) layer on the surface of multi-walled carbon nanotubes (MWCNTs) with sunset yellow (SY) as a template molecule. The prepared nanocomposites were characterized, and their electrochemical behavior towards SY was investigated. Under the optimized conditions, a glassy carbon electrode modified with the imprinted nanocomposite showed a highly selective and ultrasensitive electrochemical response to SY compared with the performance of control electrodes and previously reported electrochemical sensors for SY...
October 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29024846/attentional-control-and-executive-functioning-in-school-aged-children-linking-self-regulation-and-parenting-strategies
#8
Andrea M Spruijt, Marielle C Dekker, Tim B Ziermans, Hanna Swaab
Good parenting strategies can shape children's neurocognitive development, yet little is known about the nature of this relation in school-aged children and whether this association shifts with age. We aimed to investigate the relation between parenting strategies observed during a home visit and children's performance-based attentional control and executive functioning (N=98, aged 4-8years). Linear and curvilinear regression analyses showed that children of parents who were more supportive, were less intrusive, and asked more open-ended questions displayed better inhibitory control...
October 9, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29024343/dimensionality-and-internal-structure-of-the-colombian-version-of-the-inico-feaps-quality-of-life-scale
#9
M A Verdugo-Alonso, C P Henao-Lema, L Córdoba-Andrade, V B Arias González
BACKGROUND AND OBJECTIVE: Measuring quality of life (QoL) in people with intellectual disabilities (IDs) can help organisations and practitioners to implement evidence-based practices and develop person-centred planning and individualised supports. There is no reliable and valid instrument for assessing QoL in people with ID in Colombia. We investigated the internal structure of the Colombian version of the INICO-FEAPS scale and tested whether the scale identified the eight interrelated domains of the QoL conceptual framework originally described by...
October 10, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29024083/stimulated-transitions-of-directed-nonequilibrium-self-assemblies
#10
Alexander A Steinschulte, Andrea Scotti, Khosrow Rahimi, Oleksii Nevskyi, Alex Oppermann, Sabine Schneider, Steffen Bochenek, Marie F Schulte, Karen Geisel, Felicitas Jansen, Andre Jung, Sabrina Mallmann, Roland Winter, Walter Richtering, Dominik Wöll, Ralf Schweins, Nicholas J Warren, Felix A Plamper
Near-equilibrium stimulus-responsive polymers have been used extensively to introduce morphological variations in dependence of adaptable conditions. Far-less-well studied are triggered transformations at constant conditions. These require the involvement of metastable states, which are either able to approach the equilibrium state after deviation from metastability or can be frozen on returning from nonequilibrium to equilibrium. Such functional nonequilibrium macromolecular systems hold great promise for on-demand transformations, which result in substantial changes in their material properties, as seen for triggered gelations...
October 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29023694/adaptive-self-organization-in-the-embryo-its-importance-to-adult-anatomy-and-to-tissue-engineering
#11
REVIEW
Jamie A Davies
The anatomy of healthy humans shows much minor variation, and twin-studies reveal at least some of this variation cannot be explained genetically. A plausible explanation is that fine-scale anatomy is not specified directly in a genetic programme, but emerges from self-organizing behaviours of cells that, for example, place a new capillary where it happens to be needed to prevent local hypoxia. Self-organizing behaviour can be identified by manipulating growing tissues (e.g. putting them under a spatial constraint) and observing an adaptive change that conserves the character of the normal tissue while altering its precise anatomy...
October 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29023621/bond-strength-of-self-adhering-materials-effect-of-dentin-desensitizing-treatment-with-a-cpp-acp-paste
#12
Fereshteh Shafiei, Reza Derafshi, Mahtab Memarpour
This study investigated the effect of dentin-desensitizing treatment with a casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste on shear bond strength (SBS) of two types of self-adhering (SA) restorative materials: resin-modified glass-ionomer (Fuji II LC, GC) and self-adhering flowable composite resin (Vertise Flow, Kerr). Flat and smear layer-free dentin surfaces from 48 extracted molars were prepared and divided into four groups (n = 12 per group) according to Fuji II LC or Vertise Flow and CPP-ACP pretreatment or not...
November 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29023578/factors-related-to-environmental-barriers-experienced-by-persons-with-and-without-disabilities-in-diverse-african-settings
#13
Surona Visagie, Arne H Eide, Karin Dyrstad, Hasheem Mannan, Leslie Swartz, Marguerite Schneider, Gubela Mji, Alister Munthali, Mustafa Khogali, Gert van Rooy, Karl-Gerhard Hem, Malcolm MacLachlan
This paper explores differences in experienced environmental barriers between individuals with and without disabilities and the impact of additional factors on experienced environmental barriers. Data was collected in 2011-2012 by means of a two-stage cluster sampling and comprised 400-500 households in different sites in South Africa, Sudan Malawi and Namibia. Data were collected through self-report survey questionnaires. In addition to descriptive statistics and simple statistical tests a structural equation model was developed and tested...
2017: PloS One
https://www.readbyqxmd.com/read/29023383/aal-platform-with-a-de-facto-standard-communication-interface-tico-training-in-home-control-in-special-education
#14
Miguel A Guillomía San Bartolomé, Jorge L Falcó Boudet, José Ignacio Artigas Maestre, Ana Sánchez Agustín
Framed within a long-term cooperation between university and special education teachers, training in alternative communication skills and home control was realized using the "TICO" interface, a communication panel editor extensively used in special education schools. From a technological view we follow AAL technology trends by integrating a successful interface in a heterogeneous services AAL platform, focusing on a functional view. Educationally, a very flexible interface in line with communication training allows dynamic adjustment of complexity, enhanced by an accessible mindset and virtual elements significance already in use, offers specific interaction feedback, adapts to the evolving needs and capacities and improves the personal autonomy and self-confidence of children at school and home...
October 12, 2017: Sensors
https://www.readbyqxmd.com/read/29019683/self-assembly-pathways-of-%C3%AE-sheet-rich-amyloid-%C3%AE-1-40-dimers-markov-state-model-analysis-on-millisecond-hybrid-resolution-simulations
#15
Yang Cao, Xuehan Jiang, Wei Han
Early oligomerization during amyloid-β (Aβ) aggregation is essential for Aβ neurotoxicity. Understanding how unstructured Aβs assemble into oligomers, especially those rich in β-sheets, is essential but remains challenging as the assembly process is too transient for experimental characterization and too slow for molecular dynamics simulations. So far, atomic simulations are limited only to studies of either oligomer structures or assembly pathways for short Aβ segments. To overcome the computational challenge, we combine in this study a hybrid-resolution model and adaptive sampling techniques to perform over 2...
October 11, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29019634/pain-assessment-in-newborns-infants-and-children
#16
Alexandra Beltramini, Kolia Milojevic, Dominique Pateron
Pain in children is underestimated and undertreated because of lack of pain assessment tools. Pain assessment depends on the cognitive development of the child being tested, clinical context, and pain typology. For children older than age 6 years, pain assessment is based on a self-report. For children younger than age 6 years, behavioral pain scales are needed to assess pain. Numerous pain scales exist. Many are reliable and some are recommended, but all have specific conditions for their use. In this article, we review the available pain scales for children from birth to adolescence...
October 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29018866/are-professional-drivers-less-sleepy-than-non-professional-drivers
#17
Anna Anund, Christer Ahlström, Carina Fors, Torbjörn Åkerstedt
Objective It is generally believed that professional drivers can manage quite severe fatigue before routine driving performance is affected. In addition, there are results indicating that professional drivers can adapt to prolonged night shifts and may be able to learn to drive without decreased performance under high levels of sleepiness. However, very little research has been conducted to compare professionals and non-professionals when controlling for time driven and time of day. Method The aim of this study was to use a driving simulator to investigate whether professional drivers are more resistant to sleep deprivation than non-professional drivers...
October 11, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29018534/factors-related-to-work-and-life-satisfaction-of-veterinary-practitioners-in-germany
#18
Johanna C Kersebohm, Timo Lorenz, Anne Becher, Marcus G Doherr
OBJECTIVES: Veterinary practitioners' working situation is both challenging and changing. They have higher levels of work-related stress and suicide risk than the general population. The proportion of women is increasing, and in Germany especially women and employed veterinarians are reported to be less satisfied than comparable subgroups of the general population. In this study we identified key factors associated with work and life satisfaction among veterinary practitioners in Germany...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29018378/contextualized-contribution-of-kindness-to-favorable-goal-and-circumstantial-driven-neuropsychological-regulation
#19
Nayara Mota, Elenilda Chaves, Marina Antunes, Rudi Borges, Andressa Paiva, Vanessa Santos
Kindness involves care and non-judgmental understanding toward someone. As a prosocial inclination, kindness would increase the possibility of favorable interaction with the environment, with a successful adjustment of one's response in novel or challenging circumstances, taking into account rules or goals. This adjustment ability is commonly referred to as executive functions, dependent on the prefrontal and parietal functioning, still under development during late adolescence. This study aimed to investigate if kindness would relate with the executive functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29017894/rotavirus-encoded-virus-like-small-rna-triggers-autophagy-by-targeting-igf1r-via-the-pi3k-akt-mtor-pathway
#20
Yan Zhou, Panpan Geng, Yalin Liu, Jinyuan Wu, Hongtu Qiao, Yuping Xie, Na Yin, Linlin Chen, Xiaochen Lin, Yang Liu, Shan Yi, Guangming Zhang, Hongjun Li, Maosheng Sun
Rotaviruses are double-stranded RNA viruses that are a major cause of viral diarrhea in infants. Examining virus-host cell interaction is important for elucidating mechanisms of virus proliferation in host cells. Viruses can create an environment that promotes their survival and self-proliferation by encoding miRNAs or miRNA-like molecules that target various host cell. However, it remains unclear whether RNA viruses encode viral miRNAs, and their regulation mechanisms are largely unknown. We previously performed deep sequencing analysis to investigate rotavirus-encoded miRNAs, and identified the small RNA molecule Chr17_1755, which we named RV-vsRNA1755...
October 7, 2017: Biochimica et Biophysica Acta
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