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Bryan W Stuart, Colin A Grant, George E Stan, Adrian C Popa, Jeremy J Titman, David M Grant
The osteogenic ions Ca2+ , P5+ , Mg2+ , and antimicrobial ion Ga3+ were homogenously dispersed into a 1.45 µm thick phosphate glass coating by plasma assisted sputtering onto commercially pure grade titanium. The objective was to deliver therapeutic ions in orthopaedic/dental implants such as cementeless endoprostheses or dental screws. The hardness 4.7 GPa and elastic modulus 69.7 GPa, of the coating were comparable to plasma sprayed hydroxyapatite/dental enamel, whilst superseding femoral cortical bone...
March 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Qing Huang, Shiwei Zhou, Lina Lin, Yongchun Huang, Fangjun Li, Zhengguo Song
Herein, we utilize sequential extraction and high-throughput sequencing to investigate the effects of nanomaterial additives on As volatilization from flooded soils. We reveal that maximum volatilization is achieved in the fourth week and is followed by stabilization. The extent of volatilization decreased in the order of control > nano-zerovalent iron >40-nm hydroxyapatite > nano-Fe3 O4  > 20-nm hydroxyapatite > multilayer graphene oxide > high-quality graphene oxide. The most abundant forms of As in soil corresponded to As-Fe and Al oxides...
April 10, 2018: Environmental Pollution
Zheng Bo Lai, Ruixiang Bai, Zhenkun Lei, Cheng Yan
Biological composite materials, such as bone, tooth and nacre, are comprised of a mixture of nano-sized hard components (e.g. mineral platelets) and soft components (e.g. protein molecules). Their mechanical behaviour greatly depends on the protein-mineral interfaces. This paper investigates the effects of mineral surface nanostructures on the interfacial interaction and mechanical behaviour of protein-mineral nanocomposites. Interfacial shear between osteopontin (OPN) and hydroxyapatite (HA) mineral layers with surface nanostructures is investigated using the atomistic molecular dynamics (MD) simulations...
April 3, 2018: Journal of Biomechanics
Bailey K Barnes, Austin J Bow, Ganesh Kannarpady, Alexandru S Biris, David E Anderson, Madhu Dhar, Shawn E Bourdo
A wide variety of biomaterials are utilized in tissue engineering to generate living cells in vitro or to promote tissue growth in vivo. Regeneration of living tissue from biocompatible materials may make it possible to grow tissues ranging from bone to nerve cells. In bone regeneration, polymeric scaffolds can be enhanced by the addition of bioactive materials. To this end, this study designed several ratios of polyurethane (PU) and nano-hydroxyapatite (nHA) composites (PU-nHA ratios: 100/0, 90/10, 80/20, 70/30, 60/40 w/w)...
April 13, 2018: Journal of Biomaterials Science. Polymer Edition
Dan He, Cheng Fu, Zhigang Xue
Gold coating is a general operation that is generally applied on non-conductive or low conductive materials, during which the morphology of the materials can be examined by scanning electron microscopy (SEM). However, fatal deficiencies in the materials can result in irreversible distortion and damage. The present study directly characterized different low conductive materials such as hydroxyapatite, modified poly(vinylidene fluoride) (PVDF) fiber, and zinc oxide nanopillar by cold field emission scanning electron microscopy (FE-SEM) without a gold coating...
April 6, 2018: Micron: the International Research and Review Journal for Microscopy
Despoina Xidaki, Panagiota Agrafioti, Dimitra Diomatari, Archontia Kaminari, Eleftherios Tsalavoutas-Psarras, Polyxeni Alexiou, Vasilios Psycharis, Effie C Tsilibary, Spyridon Silvestros, Marina Sagnou
The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics...
April 12, 2018: Materials
Xiaoyu Sun, Wen Su, Xiaomin Ma, Huaiying Zhang, Zhe Sun, Xudong Li
Collagen (COL), collagen/hydroxyapatite (COL/HA), HA and biphasic calcium phosphate were prepared as representative bone grafting materials with composition analogous to bone, and their structural characteristics were analyzed. The rat bone mesenchymal stem cells (BMSCs) were further seeded onto four groups of materials, and BMSCs grown in basic medium and standard osteogenic medium were set as controls of a reference model to show the basic and osteogenic behavior of cells without the intervention of materials...
March 2018: Regenerative Biomaterials
Luyuan Chen, Satoshi Komasa, Yoshiya Hashimoto, Shigeki Hontsu, Joji Okazaki
To enhance biocompatibility, osteogenesis, and osseointegration, we coated titanium implants, by krypton fluoride (KrF) pulsed laser deposition, with a thin film of fluoridated hydroxyapatite (FHA). Coating was confirmed by scanning electron microscopy (SEM) and scanning probe microscopy (SPM), while physicochemical properties were evaluated by attenuated reflectance Fourier transform infrared spectroscopy (ATR-FTIR). Calcium deposition, osteocalcin production, and expression of osteoblast genes were significantly higher in rat bone marrow mesenchymal stem cells seeded on FHA-coated titanium than in cells seeded on uncoated titanium...
April 10, 2018: International Journal of Molecular Sciences
Yi-Ho Hsieh, Bo-Yuan Shen, Yao-Horng Wang, Bojain Lin, Hung-Maan Lee, Ming-Fa Hsieh
Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal defects in articular cartilage. Tissue engineering is the most potential solution to this problem. In this study, methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) and hydroxyapatite at a weight ratio of 2:1 were mixed via fused deposition modeling (FDM) layer by layer to form a solid scaffold. The scaffolds were further infiltrated with glycidyl methacrylate hyaluronic acid loading with 10 ng/mL of Transforming Growth Factor-β1 and photo cross-linked on top of the scaffolds...
April 9, 2018: International Journal of Molecular Sciences
Feng Song, Huayang Zhang, Shaobin Wang, Lihong Liu, Xiaoyao Tan, Shaomin Liu
We report a strategy for simultaneous cobalt removal and organic waste decomposition by using mesoporous hydroxyapatite nanoparticles wrapped in uniform carbon layers (HA@C). The in situ formation of CoOH+-HA@C due to ion exchange greatly improved the degradation efficiency by at least one order of magnitude compared to free Co2+.
April 9, 2018: Chemical Communications: Chem Comm
Junichi Kushioka, Takashi Kaito, Takahiro Makino, Hiroyasu Fujiwara, Hiroyuki Tsukazaki, Shota Takenaka, Yusuke Sakai, Hideki Yoshikawa
BACKGROUND: Lateral inter-body fusion (LIF) using cages with a large bone grafting space can lead to a shortage of autologous grafting materials. The use of artificial bone is an option to increase the volume of grafting materials. However, the rate of bony fusion for these materials compared to that of autologous bone is unclear. METHODS: The bone fusion rate for artificial bone (HAp/Col) and autologous iliac bone (IBG) graft among 23 patients who had undergone LIF (total 66 disc levels) combined with multilevel posterior corrective fusion for the treatment of adult spinal deformity was retrospectively evaluated...
April 4, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Robert N Young, Marc D Grynpas
Bisphosphonates target and bind avidly to the mineral (hydroxyapatite) found in bone. This targeting ability has been exploited to design and prepare bisphosphonate conjugate prodrugs to deliver a wide variety of drug molecules selectively to bones. It is important that conjugates be stable in the blood stream and that conjugate that is not taken up by bone is eliminated rapidly. The prodrugs should release active drug at a rate appropriate so as to provide efficacy. Radiolabelling is the best method to quantify and evaluate pharmacokinetics, tissue distribution, bone uptake and release of the active drug(s)...
April 4, 2018: Current Opinion in Pharmacology
Kazuhiko Kandori, Ryuya Murata, Yuto Yamaguchi, Ayano Yoshioka
Fundamental experiments on the adsorption behaviors of proteins onto plate-like and rod-like manganese-doped calcium hydroxyapatite particle (abbreviated as MnHAp) were examined. All of the obtained adsorption isotherms of bovine serum albumin (BSA) and lysozyme (LSZ) in a 1 × 10-4  mol/dm3 KCl solution were of the Langmuirian type. We found that the saturated amounts of the adsorbed BSA (ns BSA ) increased with the increase in Mn/(Ca + Mn) atomic ratio (abbreviated as XMn ) of the plate-like MnHAp, while the saturated amounts of adsorbed LSZ (ns LCZ ) decreased...
March 30, 2018: Colloids and Surfaces. B, Biointerfaces
Megan Still, Abdoulaye Kane, Alexandre Roux, Marc Zanello, Edouard Dezamis, Eduardo Parraga, Xavier Sauvageon, Jean-François Meder, Johan Pallud
BACKGROUND: Cranioplasties are an important neurosurgical procedure not only for improved cosmesis, but also for improved functional recover after craniectomy with a large cranial defect. The aim of this study was to identify predictive factors of post-cranioplasty complications using custom-made porous hydroxyapatite cranioplasty. METHODS: A retrospective review was conducted of all patients who underwent a reconstructive cranioplasty using custom-made hydroxyapatite at our institution between February 2008 to September 2017...
April 3, 2018: World Neurosurgery
Danushika C Manatunga, Rohini M de Silva, K M Nalin de Silva, Gathsaurie Neelika Malavige, Dulharie T Wijeratne, Gareth R Williams, Chanika D Jayasinghe, Preethi V Udagama
This study aimed to develop a drug carrier system consisting of a polymer containing hydroxyapatite (HAp) shell and a magnetic core of iron oxide nanoparticles. Doxorubicin and/or curcumin were loaded into the carrier via a simple diffusion deposition approach, with encapsulation efficiencies (EE) for curcumin and doxorubicin of 93.03 ± 0.3% and 97.37 ± 0.12% respectively. The co-loading of curcumin and doxorubicin led to a total EE of 76.02 ± 0.48%. Release studies were carried out at pH 7.4 and 5.3, and revealed higher release was at pH 5...
April 3, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Vuk Uskokovic, Sean Tang, Victoria Wu
Memory effects, despite being intrinsic to biological systems, are rarely potentiated in biomaterials. By exploring the transition between amorphous calcium phosphate (ACP) and hydroxyapatite (HAp) from different empirical angles, here we attempt to set the basis for elicitation of structural memory effects in CPs. Two CPs precipitated under different degrees of saturation (DS), yielding HAp at low DS and ACP at high DS, were shown to evolve into structures with a high level of crystallographic similarity after their prolonged aging in the solution and served as the basis for this study...
April 6, 2018: ACS Applied Materials & Interfaces
Yi Jin, Shizhu Chen, Nan Li, Yajing Liu, Gong Cheng, Cuimiao Zhang, Shuxiang Wang, Jinchao Zhang
When orthopedic joints coated by hydroxyapatite (HA) were implanted in the human body, they release wear debris into the surrounding tissues. The generation and accumulation of wear particles will induce aseptic loosening. However, the potential bioeffect and mechanism of HA-coated orthopedic implants on bone cells are poorly understood. In this study, defect-related luminescent bur-like hydroxyapatite (BHA) microspheres with the average diameter of 7-9 μm which are comparable to that of the wear-debris particles from aseptically loosened HA implants or HA debris have been synthesized by hydrothermal synthesis and the MC3T3-E1 cells were set as a cells model to study the potential bioeffect and mechanism of BHA microspheres...
March 30, 2018: Science China. Life Sciences
Huamin Hu, Bo-Wen Huang, Yan-Ting Lee, Jun Hu, Sing-Wai Wong, Ching-Chang Ko, Wei You
Bone tissue engineering (BTE) requires a sturdy biomaterial for scaffolds for restoration of large bone defects. Ideally, the scaffold should have a mechanical strength comparable to the natural bone in the implanted site. We show that adding cosolvent during the processing of our previously developed composite of hydroxyapatite-gelatin with a silane cross-linker can significantly affect its mechanical strength. When processed with tetrahydrofuran (THF) as the cosolvent, the new hydroxyapatite-gelatin composite can demonstrate almost twice the compressive strength (97 vs 195 MPa) and biaxial flexural strength (222 vs 431 MPa) of the previously developed hydroxyapatite-gelatin composite (i...
March 31, 2018: ACS Omega
Kaushik Mukherjee, Qichao Ruan, Steven Nutt, Jinhui Tao, James J De Yoreo, Janet Moradian-Oldak
The gradual discovery of functional domains in native enamel matrix proteins has enabled the design of smart bioinspired peptides for tooth enamel mimetics and repair. In this study, we expanded upon the concept of biomineralization to design smaller amelogenin-inspired peptides with conserved functional domains for clinical translation. The synthetic peptides displayed a characteristic nanostructured scaffold reminiscent of 'nanospheres' seen in the enamel matrix and effectively controlled apatite nucleation in vitro resulting in the formation of smaller crystallites...
March 31, 2018: ACS Omega
Enrico Sassoni
The present paper reviews the methods and the performance of in situ formation of calcium phosphates (CaP) for the conservation of materials belonging to cultural heritage. The core idea is to form CaP (ideally hydroxyapatite, HAP, the most stable CaP at pH > 4) by reaction between the substrate and an aqueous solution of a phosphate salt. Initially proposed for the conservation of marble and limestone, the treatment has been explored for a variety of different substrates, including sandstones, sulphated stones, gypsum stuccoes, concrete, wall paintings, archaeological bones and paper...
April 4, 2018: Materials
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