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Hydroxyapatite

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https://www.readbyqxmd.com/read/29052356/in-vitro-biocompatibility-bioactivity-and-photoluminescence-properties-of-eu-3-sr-2-dual-doped-nano-hydroxyapatite-for-biomedical-applications
#1
Lakshmanaperumal Sundarabharathi, Hemalatha Parangusan, Deepalekshmi Ponnamma, Mariam Al Ali Al-Maadeed, Mahendran Chinnaswamy
In the present investigation, we have successfully synthesized luminescent Eu(3+) -doped and Eu(3+) /Sr(2+) codoped hydroxyapatite (HA) nanoparticles through sol-gel assisted precipitation method with the aim of developing novel biomaterials containing osteoblast mineral (Sr(2+) ) and luminescence activator (Eu(3+) ). The structure, morphology, thermal stability, and luminescence properties of the resultant spherical nanoparticles (50-100 nm diameters) were studied. Moreover, the in-vitro bioactivity of Eu0...
October 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29050590/sugar-cane-bagasse-derived-cellulose-enhances-performance-of-polylactide-and-polydioxanone-electrospun-scaffold-for-tissue-engineering
#2
Honita Ramphul, Archana Bhaw-Luximon, Dhanjay Jhurry
Bagasse is a waste product of sugar extraction from sugar-cane with approximately 30% cellulose content. Cellulose was successfully extracted from sugar-cane bagasse using a modified mercerization-bleaching approach with a 40% yield. Extracted cellulose was converted to cellulose acetate for enhanced electrospinnability and blended with poly-l-Lactide or polydioxanone before solution electrospinning. Physico-chemical evaluation of the electrospun mats showed variable miscibility of blends. In vitro cell studies with L929 mouse fibroblast cells was quite conclusive as regards the biocompatibility of the blended mats with proliferative behavior of cells, extracellular matrix deposition and characteristic features of healthy cellular response...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29048704/hydroxyapatite-decreases-cytotoxicity-of-a-glass-ionomer-cement-by-calcium-fluoride-uptake-in-vitro
#3
Casiano Del Angel-Mosqueda, Rene Hernandez-Delgadillo, Osvelia E Rodríguez-Luis, María T Ramírez-Rodríguez, Silvia Munguía-Moreno, Norma V Zavala-Alonso, Juan M Solís-Soto, María A A Nakagoshi-Cepeda, Rosa I Sánchez-Nájera, Sergio E Nakagoshi-Cepeda, Claudio Cabral-Romero
BACKGROUND: Glass ionomer cements (GICs) are widely used in dentistry because of their remineralizing and cariostatic potential induced by fluoride. In vitro studies have reported cell toxicity triggered by GICs; however, the influence of hydroxyapatite (HAp) must be considered. The aim of this study was to evaluate the effect of HAp in decreasing the cytotoxicity of the GIC 3M Vitrebond in vitro. METHODS: Samples of 3M Vitrebond (powder, liquid and light-cured) were incubated in Dulbecco's modified Eagle's medium-Ham's F12 (DMEM-F12) for 24 hours at 37°C...
October 14, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/29046148/exploring-the-unique-selectivity-of-hydrophobic-cation-exchanger-nuvia-cprime-for-the-removal-of-a-major-process-impurity-a-case-study-with-igm
#4
Xuemei M He, Carsten VoB, Jidong Li
Mixed-mode chromatography is becoming an important tool for downstream process purification, as it provides the selectivity and robustness unmatched by conventional single-mode chromatographic methods. The joint action of multiple functionalities present on the ligands of mixed-mode chromatography matrices effectively enhances the separation of target molecules from impurities. Using Nuvia cPrime as an example, we elucidate the separation principles of hydrophobic cation exchange mixed-mode chromatography and its difference from traditional strong cation exchangers...
October 17, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29045789/nano-hydroxyapatite-stimulation-of-gene-expression-requires-fgf-receptor-phosphate-transporter-and-erk1-2-signaling
#5
Shin-Woo Ha, Jonathan Park, Mark M Habib, George R Beck
Hydroxyapatite (HAp) is critical to health both as the main structural material of the skeleton and storage material of calcium and phosphate. Nano-sized HAp (nHAp) is naturally produced by mineralizing cells during bone formation and remodeling and is the main constituent of the skeleton. As such, HAp is currently being investigated as a therapeutic biomaterial for orthopedic and dental purposes. Recent studies have suggested that extracellular nHAp can influence osteoblast lineage commitment and cell function through changes in gene expression, however the mechanisms remain to be elucidated...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29044984/3d-printed-calcium-phosphate-and-poly-caprolactone-composites-with-improved-mechanical-properties-and-preserved-microstructure
#6
Joseph B Vella, Ryan P Trombetta, Michael D Hoffman, Jason Inzana, Hani Awad, Danielle S W Benoit
Biphasic calcium phosphate scaffolds formed via 3D printing technology to exhibit porosity and chemical resorbability to promote osseointegration often lack the strength and toughness required to withstand loading in bone tissue engineering applications. Herein, sintering and CaP:poly(caprolactone) (PCL) composite formation were explored to improve 3D printed scaffold strength and toughness. Hydroxyapatite and α-tricalcium phosphate (α-TCP) biphasic calcium powders were printed using phosphoric acid binder, which generated monetite and hydroxyapatite scaffolds...
October 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29044948/intracellular-pathway-and-subsequent-transformation-of-hydroxyapatite-nanoparticles-in-the-saos-2-osteoblast-cell-line
#7
André L Rossi, Mariana M Longuinho, Marcelo N Tanaka, Marcos Farina, Radovan Borojevic, Alexandre M Rossi
Internalization of hydroxyapatite nanoparticles in SAOS-2 osteoblasts for 2 and 24 h was investigated in vitro using 5 and 50 µg/mL nanoparticles in culture medium. No cytotoxic effects were observed in a PrestoBlue viability assay. Focused ion beam-scanning electron microscopy and transmission electron microscopy were used to study nanoparticle trafficking inside cells and to characterize the physicochemical properties of the remodeled nanoparticles. Nanoparticles were actively internalized by cells and maintained in intracellular membrane-bound compartments...
October 17, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29044775/flexible-high-wettability-and-fire-resistant-separators-based-on-hydroxyapatite-nanowires-for-advanced-lithium-ion-batteries
#8
Heng Li, Dabei Wu, Jin Wu, Li-Ying Dong, Ying-Jie Zhu, Xianluo Hu
Separators play a pivotal role in the electrochemical performance and safety of lithium-ion batteries (LIBs). The commercial microporous polyolefin-based separators often suffer from inferior electrolyte wettability, low thermal stability, and severe safety concerns. Herein, a novel kind of highly flexible and porous separator based on hydroxyapatite nanowires (HAP NWs) with excellent thermal stability, fire resistance, and superior electrolyte wettability is reported. A hierarchical cross-linked network structure forms between HAP NWs and cellulose fibers (CFs) via hybridization, which endows the separator with high flexibility and robust mechanical strength...
October 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29042721/clinical-and-radiographic-evaluation-of-citric-acid-based-nano-hydroxyapatite-composite-graft-in-the-regeneration-of-intrabony-defects-a-randomized-controlled-trial
#9
Chaurasia Priya Dayashankar, P C Deepika, Basavarajaiah Siddaramaiah
BACKGROUND: Conventional periodontal therapy with various bone grafts has limited scope and the results are not predictable. To improve their utility, the hybridization of bioceramics and biodegradable polymers has been widely adopted to reform the mechanical properties of bone grafts. One such biodegradable polymer is POC (Poly 1,8 octanediol). Secondly, citric acid is considered as the key material in bone mineralization, which is related to the overall stability, strength and fracture resistance of bone...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042712/sensitivity-of-novel-silicate-and-borate-based-glass-structures-on-in-vitro-bioactivity-and-degradation-behaviour
#10
Elena Mancuso, Oana Bretcanu, Martyn Marshall, Kenneth W Dalgarno
Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets...
October 15, 2017: Ceramics International
https://www.readbyqxmd.com/read/29039747/development-of-useful-biomaterial-for-bone-tissue-engineering-by-incorporating-nano-copper-zinc-alloy-ncuzn-in-chitosan-gelatin-nano-hydroxyapatite-ch-g-nhap-scaffold
#11
Juan Carlos Forero, Eduardo Roa, Juan G Reyes, Cristian Acevedo, Nelson Osses
Ceramic and metallic nanoparticles can improve the mechanical and biological properties of polymeric scaffolds for bone tissue engineering (BTE). In this work, nanohydroxyapatite (nHAp) and nano-copper-zinc alloy (nCuZn) were added to a chitosan/gelatin (Ch/G) scaffold in order to investigate the effects on morphological, physical, and biocompatibility properties. Scaffolds were fabricated by a freeze-drying technique using different pre-freezing temperatures. Microstructure and morphology were studied by scanning electron microscopy (SEM), glass transition (Tg) was studied using differential scanning calorimetry (DSC), cell growth was estimated by MTT assay, and biocompatibility was examined in vitro and in vivo by histochemistry analyses...
October 17, 2017: Materials
https://www.readbyqxmd.com/read/29037260/a-novel-protein-derived-from-lamprey-supraneural-body-tissue-with-efficient-cytocidal-actions-against-tumor-cells
#12
Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han, Qingwei Li
BACKGROUND: In previous research, we found that cell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells, but the protein with cytocidal activity was unidentified. METHODS: A novel lamprey immune protein (LIP) as defense molecule was first purified and identified in jawless vertebrates (cyclostomes) using hydroxyapatite column and Q Sepharose Fast Flow column. After LIP stimulation, morphological changes of tumor cells were analysed and measured whether in vivo or in vitro...
October 16, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29036882/biomineralization-of-fucoidan-peptide-blends-and-their-potential-applications-in-bone-tissue-regeneration
#13
Harrison T Pajovich, Ipsita A Banerjee
Fucoidan (Fuc), a natural polysaccharide derived from brown seaweed algae, and gelatin (Gel) were conjugated to form a template for preparation of biomimetic scaffolds for potential applications in bone tissue regeneration. To the Fuc-Gel we then incorporated the peptide sequence MTNYDEAAMAIASLN (MTN) derived from the E-F hand domain, known for its calcium binding properties. To mimic the components of the extracellular matrix of bone tissue, the Fuc-Gel-MTN assemblies were incubated in simulated body fluid (SBF) to induce biomineralization, resulting in the formation of β-tricalcium phosphate, and hydroxyapatite (HAp)...
September 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29034467/first-insights-into-the-function-of-the-sawshark-rostrum-through-examination-of-rostral-tooth-microwear
#14
R J Nevatte, B E Wueringer, D E Jacob, J M Park, J E Williamson
Potential roles of the rostrum of sawsharks (Pristiophoridae), including predation and self-defence, were assessed through a variety of inferential methods. Comparison of microwear on the surface of the rostral teeth of sawsharks and sawfishes (Pristidae) show that microwear patterns are alike and suggest that the elongate rostra in these two elasmobranch families are used for a similar purpose (predation). Raman spectroscopy indicates that the rostral teeth of both sawsharks and sawfishes are composed of hydroxyapatite, but differ in their collagen content...
October 16, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29033393/new-bioactive-glass-scaffolds-with-exceptional-qualities-for-bone-tissue-regeneration-response-of-osteoblasts-and-osteoclasts
#15
Tia Kowal, Natalie C Hahn, Stephanie Eider, Jutta Marzillier, Daniella Marie Fodera, Ukrit Thamma, Himanshu Jain, Matthias M Falk
Tissue regeneration is a significantly improved alternative to tissue replacement by implants. It requires porous bioscaffolds for the restoration of natural tissue rather than relying on bio-inactive, often metallic implants. Recently, we developed technology for fabricating novel, nano-macroporous bioactive 'Tailored Amorphous Multi-Porous (TAMP)' hard tissue scaffolds using a 70 mol% SiO2-30 mol% CaO model composition. The TAMP silicate scaffolds, fabricated by a modified sol-gel process, have shown excellent biocompatibility via the rapid formation of hydroxyapatite in biological fluids as well as in early tests with bone forming cells...
October 16, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29032098/calcination-effect-of-borate-bearing-hydroxyapatite-on-the-mobility-of-borate
#16
Keiko Sasaki, Kenta Toshiyuki, Binglin Guo, Keiko Ideta, Yoshikazu Hayashi, Tsuyoshi Hirajima, Jin Miyawaki
Discharge from accidental nuclear power plants includes boric acid, which is used as a neutron absorbent in nuclear reactors. Co-precipitation of borate with hydroxyapatite (HAp), using Ca(OH)2, is known to be an effectively fast method for stabilization of borate as well as coexisting radioactive nuclides. To reduce bulky volume of solid residues after co-precipitation, calcination is necessary to investigate the chemical stability of targets. Calcination at 850°C resulted in the high crystalization of HAp with formation of xCaO·B2O3 as a by-phase in which x increased with a decrease in the borate contents...
October 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29031226/ectopic-vascularized-bone-formation-by-human-mesenchymal-stem-cell-microtissues-in-a-biocomposite-scaffold
#17
Rajan Narayan, Tarun Agarwal, Debasish Mishra, Somnath Maji, Sujata Mohanty, Asok Mukhopadhyay, Tapas Kumar Maiti
Three-dimensional multicellular human bone marrow mesenchymal stem cells (hBM-MSCs) are showing a great promise in the repair of bone tissue due to its osteogenic differentiation potential, mimicking in vivo microenvironment and immunomodulatory property. In the present study, the potential of hBM-MSC microtissues (MTs) in combination with a biocomposite material to form vascularized bone-like tissue at an ectopic site in an immunocompromised mouse was evaluated. The scaffold was fabricated using gelatin, carboxymethyl cellulose, polyvinyl alcohol and nano-hydroxyapatite (GCnHP) by the freeze-drying method...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29027611/preparation-of-flexible-bone-tissue-scaffold-utilizing-sea-urchin-test-and-collagen
#18
Naga Vijaya Lakshmi Manchinasetty, Sho Oshima, Masanori Kikuchi
Gonads of sea urchin are consumed in Japan and some countries as food and most parts including its tests are discarded as marine wastes. Therefore, utilization of them as functional materials would reduce the waste as well as encourage Japanese fishery. In this study, magnesium containing calcite granules collected from sea urchin tests were hydrothermally phosphatized and the obtained granules were identified as approximately 82% in mass of magnesium containing β-tricalcium phosphate and 18% in mass of nonstoichiometric hydroxyapatite, i...
October 13, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29025652/high-activity-chitosan-nano-hydroxyapatite-zoledronic-acid-scaffolds-for-simultaneous-tumor-inhibition-bone-repair-and-infection-eradication
#19
Yao Lu, Mei Li, Lihua Li, Shuzhen Wei, Xiaoming Hu, Xiaolan Wang, Guiqiu Shan, Yu Zhang, Hong Xia, Qingshui Yin
Implanted biomaterials combined tumor inhibition and bone repair property are urgently needed to address the huge bone destruction and the high local recurrence following primary surgery in bone tumor therapy. In this work, a high-activity chitosan/nano hydroxyapatite (CS/nHA) scaffold containing zoledronic acid (CS/nHA/Zol) was prepared with a facile method. The prepared CS/nHA/Zol scaffolds exhibited excellent tumor inhibition property towards giant cell tumor of bone (GCT) in vitro through inducing cells apoptosis by up-regulating pro-apoptosis genes expression and reducing the osteoclastic activity of tumor cells by down-regulating osteoclastic genes...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025651/hierarchically-porous-structure-mechanical-strength-and-cell-biological-behaviors-of-calcium-phosphate-composite-scaffolds-prepared-by-combination-of-extrusion-and-porogen-burnout-technique-and-enhanced-by-gelatin
#20
Shenglei Feng, Fupo He, Jiandong Ye
In this study, hierarchically porous calcium phosphate scaffolds (HTCP) with unidirectional pores, transversely interconnected pores, and micropores were fabricated by the combination of extrusion and porogen burnout technique. Gelatin was incorporated into the HTCP scaffolds by vacuum-impregnation of gelatin solution and subsequent freeze-drying. The phase composition, microstructure, physical and cytobiological properties were analyzed. The results showed that the HTCP scaffolds were composed of β-tricalcium phosphate with minor hydroxyapatite...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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