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Hydroxyapatite

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https://www.readbyqxmd.com/read/28636926/enhanced-human-bone-marrow-mesenchymal-stromal-cell-adhesion-on-scaffolds-promotes-cell-survival-and-bone-formation
#1
Miryam Mebarki, Laura Coquelin, Pierre Layrolle, Séverine Battaglia, Marine Tossou, Philippe Hernigou, Hélène Rouard, Nathalie Chevallier
In order to induce an efficient bone formation with human bone marrow mesenchymal stromal cells (hBMSC) associated to a scaffold, it is crucial to determine the key points of the hBMSC action after in vivo transplantation as well as the appropriate features of a scaffold. To this aim we compared the hBMSC behavior when grafted onto two biomaterials allowing different bone potential in vivo. The cancellous devitalized Tutoplast®-processed bone (TPB) and the synthetic hydroxyapatite/β-tricalcium-phosphate (HA/βTCP) which give at 6 weeks 100% and 50% of bone formation respectively...
June 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28635141/high-sensitivity-non-invasive-detection-of-calcifications-deep-inside-biological-tissue-using-transmission-raman-spectroscopy
#2
Adrian Ghita, Pavel Matousek, Nick Stone
The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28632254/osteogenic-potential-of-gingival-mesenchymal-stem-cells-over-titanium-machined-surfaces
#3
Julio A Carrion, Junaid Rajani, Mohamed Al Bahrawy, Xiaojun Chan, Tae Jin Kim, Srinivas Myneni, Vincent J Iacono
PURPOSE: To evaluate the biochemical composition of bone nodules deposited by gingival mesenchymal stem cells (GMSCs) over titanium machined surfaces in vitro. MATERIALS AND METHODS: GMSCs were isolated from healthy gingival tissues of patients undergoing crown-lengthening surgical procedures. GMSCs were characterized following the International Society for Cellular Therapy guidelines. After incubation of the GMSCs with titanium discs, osteogenic differentiation was induced for 28 days...
June 20, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28631013/in-vivo-evaluation-of-the-bone-integration-of-coated-poly-vinyl-alcohol-hydrogel-fiber-implants
#4
David Moreau, Arthur Villain, Manon Bachy, Henry Proudhon, David N Ku, Didier Hannouche, Hervé Petite, Laurent Corté
Recently, it has been shown that constructs of poly(vinyl alcohol) (PVA) hydrogel fibers reproduce closely the tensile behavior of ligaments. However, the biological response to these systems has not been explored yet. Here, we report the first in vivo evaluation of these implants and focus on the integration in bone, using a rabbit model of bone tunnel healing. Implants consisted in bundles of PVA hydrogel fibers embedded in a PVA hydrogel matrix. Half of the samples were coated with a composite coating of hydroxyapatite (HA) particles embedded in PVA hydrogel...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28629107/reducing-the-bioavailability-and-leaching-potential-of-lead-in-contaminated-water-hyacinth-biomass-by-phosphate-assisted-pyrolysis
#5
Lingna Shi, Lijun Wang, Tao Zhang, Jianfa Li, Xiaoyi Huang, Jing Cai, Jinhong Lü, Yue Wang
For the purpose of safe disposal of biomass contaminated by biosorption of heavy metals, phosphate-assisted pyrolysis of water hyacinth biomass contaminated by lead (Pb) was tried to reduce the bioavailability and leaching potential of Pb, using direct pyrolysis without additive as a control method. Direct pyrolysis of the contaminated biomass at low temperatures (300 and 400°C) could reduce the bioavailability of Pb, but the leaching potential of Pb was increased with the rising pyrolysis temperature. While phosphate-assisted pyrolysis significantly enhanced the recovery and stability of Pb in the char...
June 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28629095/solvothermal-synthesis-of-hydroxyapatite-nanorods-with-assistance-of-green-polymer
#6
Hui Yang, Tongxiang Liang, Xiaopeng Qi, Honghui Jiang, Yiqun Deng, Ping Wang, Huichang Gao
Development of low cost, environmental friendly crystal growth modifying reagents that are effective to HAp's microstructure regulation is highly crucial. Herein, sodium lignin sulfonate (SS), a byproduct of the pulp process, was used for preparing HAp nanorods. Results showed that both stirring time of reaction solution and the concentration of SS affected crystals' structure and aspect ratio. The growth mechanism was discussed on the basis of the results. And we hope this new synthetic strategy will offer an attractive route for the design of functional HAp nano-/micro- materials with fine structure...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629092/binary-functional-porous-multi-mineral-substituted-apatite-nanoparticles-for-reducing-osteosarcoma-colonization-and-enhancing-osteoblast-cell-proliferation
#7
Dharman Govindaraj, Chandramohan Govindasamy, Mariappan Rajan
We investigated the use of combined nanoparticles in bone replacement for patients with bone cancer. Bismuth (Bi) is known to have antitumor effects, and the inclusion of Bi in bioactive mineral (M)-substituted hydroxyapatite (M-HAP) may provide anti-cancer properties implant resources. A series of Bi-substituted M-HAP (Bi-M-HAP) nanoparticles with various Bi concentrations was synthesized via the ultrasound irradiation method. The nanoparticles were examined using physicochemical strategies. The cell-substance interface of the nanoparticles was observed in vitro with human osteosarcoma cells and cell multiplication was measured at 1, 3, and 7days of incubation and in vivo in rats after 3weeks of implantation...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629083/effects-on-insulin-adsorption-due-to-zinc-and-strontium-substitution-in-hydroxyapatite
#8
Luisa A Scudeller, Elena Mavropoulos, Marcelo N Tanaka, Andrea M Costa, Carolina A C Braga, Elvis O López, Alexandre Mello, Alexandre M Rossi
Insulin-loaded calcium phosphate nanoparticles have been proposed as a potential drug delivery system for the oral treatment of diabetes and to stimulate bone cell proliferation and bone mineralization. The kinetics of insulin incorporation onto hydroxyapatite (HA) and Sr (SrHA)- and Zn (ZnHA)-substituted hydroxyapatite nanoparticles was investigated using X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy, zeta potential measurements and circular dichroism (CD) spectroscopy...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629069/evaluation-of-electrospun-biomimetic-substrate-surface-decorated-with-nanohydroxyapatite-precipitation-for-osteoblasts-behavior
#9
Sai Zhang, Guojun Jiang, Molamma P Prabhakaran, Xiaohong Qin, Seeram Ramakrishna
To engineer bone tissue, it is crucial to design scaffolds with micro- and nano-sized architecture imitating approximate hierarchical structure of native bone, and afford desirable biological properties by introducing biocompatible polymers and bioceramics into the scaffolds. Here, a novel scaffold consisting of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV)/polyaspartic acid (PAA) was fabricated by electrospinning and nano-hydroxyapatite (nHA) was deposited by calcium-phosphate dipping process for bone tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629063/substitution-of-strontium-and-boron-into-hydroxyapatite-crystals-effect-on-physicochemical-properties-and-biocompatibility-with-human-wharton-jelly-stem-cells
#10
Joanna Kolmas, Frédéric Velard, Aneta Jaguszewska, Flora Lemaire, Halima Kerdjoudj, Sophie C Gangloff, Agnieszka Kaflak
Hydroxyapatite (HA) enriched with strontium and boron ions was synthesized using two different methods: the precipitation method (Sr,B-HAw) and the dry method (Sr,B-HAd). Additionally, for the sake of comparison, the "pure" unsubstituted HA was prepared together with HAs substituted only with one type of a foreign ion. The obtained materials were subjected to physicochemical analysis with the use of various analytical methods, such as powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), inductively coupled plasma optical emission spectroscopy (ICP-OES), Fourier transform infrared spectroscopy (FT-IR) and solid-state proton nuclear magnetic resonance ((1)H ssNMR)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629061/paclitaxel-hydroxyapatite-composite-coatings-on-titanium-alloy-for-biomedical-applications
#11
Yu-Liang Lai, Shuei-Bin Lai, Shiow-Kang Yen
In order to reduce the side effects of chemotherapy, target therapies have been spotlighted. In this study, paclitaxel, the drug for cancer treatment, is electrochemically deposited on Ti alloy as vascular stents for the tumor localized therapy by sustaining drug releasing to achieve the cancer cells apoptosis or the prevention of cancer metastasis. In the experiment, cathodic polarization tests coupled with electrochemical reactions were analyzed to speculate the deposition mechanism, and the field emission scanning electron microscope (FESEM), focused ion beam (FIB) system and Fourier transform infrared spectroscopy (FTIR) to observe the surface morphology and analyze constituent elements...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629044/recovery-evaluation-of-rats-damaged-tibias-implantation-of-core-shell-structured-bone-scaffolds-made-using-hollow-braids-and-a-freeze-thawing-process
#12
Jia-Horng Lin, Mong-Chuan Lee, Chih-Kuang Chen, Chien-Lin Huang, Yueh-Sheng Chen, Shih-Peng Wen, Shu-Ting Kuo, Ching-Wen Lou
This study prepares biodegradable bone scaffolds helping the recovery of damaged tibias of rats. Polyvinyl alcohol (PVA) plied yarns are fabricated into hollow braids. The braids are combined with hydroxyapatite (HA)/gelatin/PVA mixtures and processed using freeze-thawing and freeze-drying processes in order to form bone scaffolds. These bone scaffolds are observed by scanning electron scope (SEM) and tested for compression strength. Afterwards, recovery of damaged bone, the morphology of the bone, and the histological observation are evaluated...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629027/electrophoretic-deposition-of-hydroxyapatite-hexagonal-boron-nitride-composite-coatings-on-ti-substrate
#13
Yapıncak Göncü, Merve Geçgin, Feray Bakan, Nuran Ay
In this study, commercial pure titanium samples were coated with nano hydroxyapatite-nano hexagonal boron nitride (nano HA-nano hBN) composite by electrophoretic deposition (EPD). The effect of process parameters (applied voltage, deposition time and solid concentration) on the coating morphology, thickness and the adhesion behavior were studied systematically and crack free nano hBN-nano HA composite coating production was achieved for developing bioactive coatings on titanium substrates for orthopedic applications...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629025/polycaprolactone-and-polycaprolactone-ceramic-based-3d-bioplotted-porous-scaffolds-for-bone-regeneration-a-comparative-study
#14
K K Gómez-Lizárraga, C Flores-Morales, M L Del Prado-Audelo, M A Álvarez-Pérez, M C Piña-Barba, C Escobedo
One of the critical challenges that scaffolding faces in the organ and tissue regeneration field lies in mimicking the structure, and the chemical and biological properties of natural tissue. A high-level control over the architecture, mechanical properties and composition of the materials in contact with cells is essential to overcome such challenge. Therefore, definition of the method, materials and parameters for the production of scaffolds during the fabrication stage is critical. With the recent emergence of rapid prototyping (RP), it is now possible to create three-dimensional (3D) scaffolds with the essential characteristics for the proliferation and regeneration of tissues, such as porosity, mechanical strength, pore size and pore interconnectivity, and biocompatibility...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629020/a-comparative-in-vivo-evaluation-of-bioactive-glasses-and-bioactive-glass-based-composites-for-bone-tissue-repair
#15
Devis Bellucci, Alexandre Anesi, Roberta Salvatori, Luigi Chiarini, Valeria Cannillo
In this work a set of novel materials for bone tissue regeneration have been tested in vivo in an animal model. In fact, despite many studies have been devoted to amorphous 45S5 Bioglass®, there is lack in the literature of works aimed to study the in vivo performance of heat-treated - and thus partially crystallized - 45S5. As widely reported, crystallization limits the bioactivity of 45S5 and is the main reason that prevents a broader use of this material. Thus, in the present work, a recently developed bioactive glass (BG_Ca/Mix) is tested, since previous investigations demonstrated that BG_Ca/Mix is particularly promising by virtue of both its high bioactivity and lower tendency to crystallize with respect to 45S5...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629016/effect-of-stearic-acid-modified-hap-nanoparticles-in-different-solvents-on-the-properties-of-pickering-emulsions-and-hap-plla-composites
#16
Ming Zhang, Ai-Juan Wang, Jun-Ming Li, Na Song
Stearic acid (Sa) was used to modify the surface properties of hydroxyapatite (HAp) in different solvents (water, ethanol or dichloromethane(CH2Cl2)). Effect of different solvents on the properties of HAp particles (activation ratio, grafting ratio, chemical properties), emulsion properties (emulsion stability, emulsion type, droplet morphology) as well as the cured materials (morphology, average pore size) were studied. FT-IR and XPS results confirmed the interaction occurred between stearic acid and HAp particles...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629013/a-novel-bioactive-vaterite-containing-tricalcium-silicate-bone-cement-by-self-hydration-synthesis-and-its-biological-properties
#17
Yin Zhang, Zhenning Wu, Yan Shu, Fei Wang, Weijing Cao, Wenhui Li
A novel bioactive vaterite-containing tricalcium silicate bone cement (V5) was successfully synthesized through self hydration and carbonization, by introducing CO2 into the hydration process of Ca3SiO5 (C3S). The purpose of this work is to reduce the adverse effect of the hydration products Ca(OH)2 on the C3S bone cement, and improve further the bioactivity of the C3S bone cement. XRD and FT-IR analysis indicated that vaterite was successfully formed in tricalcium silicate bone cement. The in vitro bioactivity of V5 was investigated by soaking in simulated body fluid (SBF) for various periods (1, 3, 7days), in addition to setting time, compressive strength and cell behavior...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628995/in-simulated-body-fluid-performance-of-polymorphic-apatite-coatings-synthesized-by-pulsed-electrodeposition
#18
Shoujie Liu, Hejun Li, Leilei Zhang, Xuemin Yin, Yao Guo
Surface modification is to modify biological responses through changing surface properties without reducing the mechanical properties of the implant. Specifically bioactive coatings, such as hydroxyapatite, carbonate apatite and dicalcium phosphate dehydrate, have been deposited on carbon/carbon (C/C) composites to change the bio-inert surface state. This work focused on the effects of voltages and electrolyte concentrations of pulsed electrodeposition on apatite layer. The apatite coatings thus synthesized were then structurally, morphologically and chemically characterized using X-ray diffraction, scanning electron microscopy, Transmission electron microscopy and Fourier-transform infrared spectroscopy...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28627673/release-characteristics-of-bone%C3%A2-like-hydroxyapatite-poly-amino-acid-loaded-with-rifapentine-microspheres-in%C3%A2-vivo
#19
Yuwu Liu, Jiming Zhu, Dianming Jiang
Bone-like hydroxyapatite/poly amino acid (BHA/PAA) is a potential bone repair material. Rifapentine-loaded poly(lactic‑co‑glycolic acid) microspheres (RPMs) are bioactive and efficient controlled‑release delivery systems used in vitro. The aim of the present study was to investigate the in vivo drug release characteristics of RPM‑loaded BHA/PAA on a rabbit model of bone defect. RPM was combined with BHA/PAA to obtain the drug‑loaded, slow‑releasing bioactive material. Bone defects were generated in New Zealand white rabbits and the rabbits were then implanted with RPM‑loaded BHA/PAA...
June 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28626286/synergistic-effect-of-fluoride-and-laser-irradiation-for-the-inhibition-of-the-demineralization-of-dental-enamel
#20
Raymond Lee, Kenneth H Chan, Jamison Jew, Jacob C Simon, Daniel Fried
Both laser irradiation and fluoride treatment alone are known to provide increased resistance to acid dissolution. CO2 lasers tuned to a wavelength of 9.3 μm can be used to efficiently convert the carbonated hydroxyapatite of enamel to a much more acid resistant purer phase hydroxyapatite (HAP). Further studies have shown that fluoride application to HAP yields fluoroapatite (FAP) which is even more resistant against acid dissolution. Previous studies show that CO2 lasers and fluoride treatments interact synergistically to provide significantly higher protection than either method alone, but the mechanism of interaction has not been elucidated...
January 28, 2017: Proceedings of SPIE
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