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https://www.readbyqxmd.com/read/28431119/survival-benefit-of-adding-docetaxel-cisplatin-and-5-fluorouracil-induction-chemotherapy-to-concurrent-chemoradiotherapy-for-locally-advanced-nasopharyngeal-carcinoma-with-nodal-stage-n2-3
#1
Masahiro Kawahira, Tomoya Yokota, Satoshi Hamauchi, Yusuke Onozawa, Hirofumi Ogawa, Tsuyoshi Onoe, Tomoyuki Kamijo, Yoshiyuki Iida, Tetsuo Nishimura, Tetsuro Onitsuka, Hirofumi Yasui
Background: Concurrent chemoradiotherapy followed by adjuvant chemotherapy (CCRT-AC) has been established as the standard of care in locally advanced nasopharyngeal carcinoma (LA-NPC). The survival benefit of induction chemotherapy (ICT) for LA-NPC remains controversial. We analyzed the efficacy and feasibility of docetaxel, cisplatin and 5-fluorouracil (TPF) ICT followed by CCRT for LA-NPC with nodal Stage N2-3. Methods: We performed a retrospective analysis of 28 LA-NPC patients with nodal Stage N2-3 receiving induction TPF followed by CCRT (TPF group; n = 12) or CCRT-AC (CCRT group; n = 16) between October 2006 and May 2016...
April 20, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28429677/increased-expression-of-cullin-3-in-nasopharyngeal-carcinoma-and-knockdown-inhibits-proliferation-and-invasion
#2
Ruifang Zeng, Guolin Tan, Wei Li, Yanhong Ma
This study aimed to investigate the clinical significance of Cullin 3 expression in nasopharyngeal carcinoma (NPC), aswell as explore the regulatory mechanism of Cullin 3 underlying the growth and metastasis of NPC cells. Our findings showed that the expression levels of Cullin 3 expression were significantly increased in both NPC tissues and cell lines. A strong positive correlation was found between the Cullin 3 expression and Ki67-based proliferation index in NPC tissues. Moreover, Cullin 3 overexpression was correlated with the local relapse and distant metastasis in NPC patients...
April 18, 2017: Oncology Research
https://www.readbyqxmd.com/read/28429051/induction-chemotherapy-followed-by-concurrent-chemoradiotherapy-vs-concurrent-chemoradiotherapy-for-locoregionally-advanced-nasopharyngeal-carcinoma-a-retrospective-cohort-study
#3
Jianyuan Zhang, Shaojun Chen, Guisheng Li, Weihua Zhang, Tingting Qin, Ping Yin, Haixin Huang, Hongwei Jiang
PURPOSE: To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy vs. concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma (NPC). METHODS: We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + CCRT) and the other with only concurrent chemoradiotherapy (CCRT). All patients received cisplatin 80 mg/m(2) 3 weeks one cycle concurrently with intensity-modulated radiation therapy, and three IC protocols were included for the IC + CCRT group...
April 20, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28427216/the-challenge-in-treating-locally-recurrent-t3-4-nasopharyngeal-carcinoma-the-survival-benefit-and-severe-late-toxicities-of-re-irradiation-with-intensity-modulated-radiotherapy
#4
Yun-Ming Tian, Wei-Zeng Huang, Xia Yuan, Li Bai, Chong Zhao, Fei Han
BACKGROUND: Effective treatments for patients with advanced locally recurrent nasopharyngeal carcinoma (NPC) are limited. This investigation was to determine the potential benefits from re-irradiation by intensity-modulated radiotherapy (IMRT) on survival and the effects of severe late toxicities. METHODS: A retrospective study was conducted in 245 patients diagnosed with locally recurrent T3-T4 NPC who had undergone re-irradiation with IMRT. Follow-up data was colletedand factors associated with survival and severe late toxicities were analyzed...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423694/epstein-barr-virus-ebv-encoded-small-rnas-ebers-associated-with-poor-prognosis-of-head-and-neck-carcinomas
#5
Turunen Aaro, Rautava Jaana, Grénman Reidar, Syrjänen Kari, Syrjänen Stina
BACKGROUND: Epstein-Barr virus (EBV) is the main cause of nasopharyngeal carcinoma (NPC), also found in other head and neck carcinomas (HNSCCs) where its role remains controversial. RESULTS: EBV was found in 80% and 21% of the samples with PCR and ISH (in cancer cells), respectively. Eight of ISH-positive samples were not NPCs. EBER-RNA detection in carcinoma cells was associated with worse prognosis, whether or not NPCs were included. HPV/EBV and HSV/HPV coinfections associated with a shorter survival...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423621/epstein-barr-virus-encoded-microrna-bart7-regulates-radiation-sensitivity-of-nasopharyngeal-carcinoma
#6
Wei Gao, Zeng-Hong Li, Siqi Chen, Jimmy Yu-Wai Chan, Min Yin, Min-Juan Zhang, Thian-Sze Wong
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is very sensitive to radiotherapy. To date, the underlying mechanism remains poorly understood. Here, we demonstrated that expression of EBV-encoded microRNA BART7 (ebv-miR-BART7) increases responsiveness of NPC to radiation treatment by targeting GFPT1/TGFβ1 signaling. GFPT1 is the the key rate-limiting enzyme of the hexosamine signaling pathway and governs TGFβ1 production. TGFβ1, a pleotropic cytokine with the potency to trigger self-renewal and damage-repair machinery in somatic cells...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421724/a-national-study-of-survival-trends-and-conditional-survival-in-nasopharyngeal-carcinoma-analysis-of-the-national-population-based-surveillance-epidemiology-and-end-results-registry
#7
Jia-Wei Lv, Xiao-Dan Huang, Yu-Pei Chen, Guan-Qun Zhou, Ling-Long Tang, Yan-Ping Mao, Wen-Fei Li, Ai-Hua Lin, Jun Ma, Ying Sun
Purpose: Conditional survival (CS) provides important information on survival for a period of time after diagnosis. Currently, information on CS patterns of patients with nasopharyngeal carcinoma (NPC) is lacking. We aimed to analyze survival rate over time and estimate CS for NPC patients using a national population-based registry. Materials and Methods: Patients diagnosed with NPC between 1973-2007 with at least 5-years follow-up were identified from the Surveillance Epidemiology End...
April 19, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28421207/detection-of-human-papillomavirus-genotypes-and-epstein-barr-virus-in-nasopharyngeal-carcinomas-at-the-korle-bu-teaching-hospital-ghana
#8
Du-Bois Asante, Richard Harry Asmah, Andrew Anthony Adjei, Foster Kyei, David Larbi Simpong, Charles Addoquaye Brown, Richard Kwasi Gyasi
Nasopharyngeal carcinomas (NPC) are endemic in Far East Asia and commonly harbour Epstein-Barr virus (EBV) which is known to serve as a key oncogenic promoter. Human papillomavirus (HPV) is known to contribute to the pathogenesis of NPC. However, in Ghana these two viruses have not been linked to NPC prevalence. This study was designed to determine the HPV genotypes and EBV involved in NPC tissue biopsies. A retrospective study design involving 72 formalin-fixed paraffin-embedded tissue (FFPET) samples of NPC from 2006 to 2012 were retrieved from the Department of Pathology, University of Ghana School of Biomedical and Allied Health Sciences...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28421114/status-of-epstein-barr-virus-coinfection-with-helicobacter-pylori-in-gastric-cancer
#9
REVIEW
Shyam Singh, Hem Chandra Jha
Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, H. pylori and EBV...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/28420597/discrepant-lesion-size-estimated-on-t1-and-fat-suppressed-t2-weighted-mri-diagnostic-value-for-differentiation-between-inflammatory-pseudotumor-and-carcinoma-of-the-nasopharynx
#10
Hye Na Jung, Hyung Jin Kim, Yi Kyung Kim, Mina Song, Ha Yeon Kim, Kyung Min Park, Jihoon Cha, Sung Tae Kim
PURPOSE: Nasopharyngeal inflammatory pseudotumor (NIPT) is hard to differentiate from infiltrating nasopharyngeal carcinoma (NPC) on conventional magnetic resonance imaging (MRI). The purpose of this study is to determine whether discrepant lesion sizes estimated on T1- and fat-suppressed T2-weighted images can help distinguish between NIPT and NPC. METHODS: We retrospectively reviewed MRI data of histologically proven 14 NIPTs and 18 infiltrating NPCs. We measured the area of the lesion on contrast-enhanced T1-weighted, unenhanced T1-weighted, and fat-suppressed T2-weighted images by placing the largest possible polygonal region-of-interest within the lesion at the same level...
April 19, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28418901/chemoradiotherapy-enhanced-the-efficacy-of-radiotherapy-in-nasopharyngeal-carcinoma-patients-a-network-meta-analysis
#11
REVIEW
Jian He, Ping Wu, Yaoyun Tang, Sulai Liu, Chubo Xie, Shi Luo, Junfeng Zeng, Jing Xu, Suping Zhao
OBJECT: A Bayesian network meta-analysis (NMA) was conducted to estimate the overall survival (OS) and complete response (CR) performance in nasopharyngeal carcinoma (NPC) patients who have been given the treatment of radiotherapy, concurrent chemoradiotherapy (C), adjuvant chemotherapy (A), neoadjuvant chemotherapy (N), concurrent chemoradiotherapy with adjuvant chemotherapy (C+A), concurrent chemoradiotherapy with neoadjuvant chemotherapy (C+N) and neoadjuvant chemotherapy with adjuvant chemotherapy (N+A)...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418897/treatment-for-retropharyngeal-metastatic-undifferentiated-squamous-cell-carcinoma-from-an-unknown-primary-site-results-of-a-prospective-study-with-irradiation-to-nasopharyngeal-mucosa-plus-bilateral-neck
#12
Chengrun Du, Hongmei Ying, Youwang Zhang, Yafang Huang, Ruiping Zhai, Chaosu Hu
Background and Objetive: To evaluate treatment outcomes for patients with retropharyngeal metastatic undifferentiated squamous cell carcinoma (SCC) from an unknown primary site. METHODS: From January 2005 to January 2015, patients who presented with enlarged retropharyngeal nodes underwent transoral sonography-guided fine-needle aspiration to confirm histology. Those with metastatic undifferentiated SCC with unknown primary tumors were treated with radical radiotherapy to nasopharyngeal mucosa plus bilateral neck...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418781/induction-chemotherapy-plus-concurrent-chemoradiotherapy-vs-concurrent-chemoradiotherapy-in-elderly-patients-with-advanced-nasopharyngeal-carcinoma
#13
Chunlin Wang, Xi Tang, Jiaojian Wang, Jian Song, Yanhua Xu
Objective This study aimed to compare survival and toxicity between induction chemotherapy followed by concurrent chemoradiotherapy (IC + CCRT) and concurrent chemoradiotherapy (CCRT) alone in elderly patients with advanced nasopharyngeal carcinoma (NPC). Study Design Propensity-matched analysis of survival and toxicity in a retrospective elderly cohort. Setting Department of Medical Oncology, Jingzhou Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Subjects and Methods In total, 193 patients with stage III to IVb NPC who were treated with IC + CCRT or CCRT alone were enrolled...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28415696/role-of-interleukin-12-gene-polymorphisms-in-the-onset-risk-of-cancer-a-meta-analysis
#14
Yi Zheng, Meng Wang, Tian Tian, Kang Liu, Xinghan Liu, Yajing Zhai, Shuai Lin, Pengtao Yang, Shanli Li, Zhijun Dai, Jun Lu
Many molecular epidemiologic studies have explored the possible links between interleukin-12 (IL-12) polymorphisms and various cancers. However, results from these studies remain inconsistent. This meta-analysis is aimed to shed light on the associations between three common loci (rs568408, rs2243115, rs3212227) of IL-12 gene and overall cancer risk. Our meta-analysis finally included 33 studies comprising 10,587 cancer cases and 12,040 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the cancer risk...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415585/serum-cd166-a-novel-biomarker-for-predicting-nasopharyngeal-carcinoma-response-to-radiotherapy
#15
Huan Lin, Ze-Tan Chen, Xiao-Dong Zhu, Ling Li, Song Qu, Wei Zhao, Fang Su, Jing-Ni Wei, Zhong-Guo Liang, Qi-Yan Mo, Jiang-Bo Wu, Hui-Ling Meng
The present study aimed to identify whether CD166 can be used as a biomarker for predicting the response of nasopharyngeal carcinoma (NPC) to radiotherapy. The serum concentration of CD166 in patients with NPC were detected by enzyme-linked immunosorbent assay. The secreted level of CD166 with radioresistant NPC was significantly higher than that with radiosensitive NPC. In vitro, the CD166 positive rate in the CNE2 cell membrane was significantly lower than that in the CNE2R cell membrane. The magnetic-activated cell sorting technology was used to obtain CNE-2R-CD166(+) and CNE-2R-CD166(-) cell lines...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414554/antitumor-activity-of-the-pachymic-acid-in-nasopharyngeal-carcinoma-cells
#16
Yan-Hua Zhang, Yong Zhang, Xiu-Ying Li, Xu-Dong Feng, Wei Jian, Rong-Qing Li
OBJECTIVE: To investigate the antitumour efficacy of pachymic acid (PA), which is a fungal extract component, on nasopharyngeal carcinoma (NPC) cells CNE-1, CNE-2. METHODS: We have chosen NPC cell line CNE-2 for the study, and the cells were treated with PA before the detection. CCK-8 assay was used to detect the proliferative ability, and Annexin V-PI double staining was used for the detection of apoptosis rate; and the nucleus damage was detected by transmission electron microscope, the protein expression of the DNA damage pathway were detected by Western blot...
April 17, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28413641/serum-mir-20a-is-a-promising-biomarker-for-gastric-cancer
#17
Ruirui Yang, Yun Fu, Ying Zeng, Mengqin Xiang, Yufang Yin, Li Li, Haifan Xu, Jing Zhong, Xi Zeng
Gastric cancer (GC) is a common type of cancer, particularly in China. Numerous studies have demonstrated that circulating microRNAs (miRNAs) have potential applications as noninvasive biomarkers for cancer diagnosis and prognosis. Microarray-based serum miRNA profiling was performed on the serum of 12 paired pre- and post-operative GC patients to screen differentially expressed serum miRNAs. Twelve different serum miRNAs between pre- and post-operative GC patients were identified. Those miRNAs were verified by real-time quantitative polymerase chain reaction in 110 paired pre- and post-operative serum samples from 55 GC patients...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28413404/yellow-pattern-577-nm-micropulse-laser-treatment-of-macular-edema-from-radiation-retinopathy-a-case-report
#18
James G Wong, Trang T H Nguyen
We report a case of a 60-year-old Asian male who developed radiation retinopathy 23 years after initial radiotherapy for nasopharyngeal carcinoma and was successfully treated with yellow pattern 577-nm micropulse laser. Secondary macular edema and visual acuity improved following a single treatment session with minimal scarring. Yellow pattern micropulse laser is a safe and effective treatment for macular edema secondary to radiation retinopathy.
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28413147/branchial-cleft-cyst-an-unusual-site-for-the-cervical-metastasis-of-nasopharyngeal-carcinoma
#19
Yu-Chang Liao, Mohamad Adel, Li-Yu Lee, Kai-Ping Chang
OBJECTIVE: Cancers found in the resected branchial cleft cyst are rare clinically but usually impose substantive diagnostic and treatment challenges for clinicians. METHODS: A 31-year-old man presented with a lateral neck mass that was suspected to be an inflammatory branchial cleft cyst. After excision, the pathologic specimen revealed a benign cystic appearance with a focus of undifferentiated carcinoma. Serologic tests for Epstein-Barr virus were negative. A positron emission tomography scan and upper aerodigestive tract endoscopies were negative for any other suspicious lesion...
April 13, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28411554/emodin-suppresses-the-nasopharyngeal-carcinoma-cells-by-targeting-the-chloride-channels
#20
Lianshun Ma, Yaping Yang, Zizhang Yin, Mei Liu, Liwei Wang, Lixin Chen, Linyan Zhu, Haifeng Yang
Emodin is a natural anthraquinone derivative isolated from the Rheum palmatum. Recent studies demonstrated that emodin has anti-cancer activity in different kinds of human cancer cell lines. However, the underlying mechanism has not been very well studied. Our previous studies showed chloride channels is an important target of anti-cancer drugs. Therefore, the purpose of this research was aimed to explore the role of chloride channels involving in the anti-cancer activity of emodin. The proliferation, cell cycle arrest and apoptosis of poorly differentiated human nasopharyngeal carcinoma cells (CNE-2Z) and normal nasopharyngeal epithelial cells (NP69-SV40T) were detected by 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide(MTT)and flow cytometry...
April 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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