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https://www.readbyqxmd.com/read/28320166/the-duration-of-the-cortical-silent-period-is-not-abnormal-in-restless-legs-syndrome-willis-ekbom-disease
#1
Joselisa Péres Queiroz de Paiva, Samir Câmara Magalhães, Gilmar Fernandes do Prado, Alan Luiz Eckeli, Alain Kaelin-Lang, Adriana Bastos Conforto
OBJECTIVE: To compare the duration of the cortical silent period (CSP) measured in a hand muscle in subjects with primary Restless Legs Syndrome (RLS/WED) and controls, using four different methods of analysis. METHODS: The CSP to transcranial magnetic stimulation of the dominant motor cortex was assessed in the abductor digiti minimi of 33 subjects with RLS/WED and 24 controls. CSP duration was measured by an automated and three visually-guided methods. RESULTS: There were significant differences between absolute values of CSP duration according to the method of analysis...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319266/benzodiazepines-for-restless-legs-syndrome
#2
REVIEW
Karla Carlos, Gilmar F Prado, Camila Dm Teixeira, Cristiane Conti, Marcio M de Oliveira, Lucila Bf Prado, Luciane Bc Carvalho
BACKGROUND: Restless legs syndrome (RLS) is a common disease affecting about 5% to 15% of the population. Symptoms of RLS can be severe in a minority of and can have a major impact on sleep, mostly sleep initiation, and quality of life. Benzodiazepines are drugs that can induce and maintain sleep and, hence, intuitively are thought to be beneficial to people with RLS. Altough benzodiazepines, particularly clonazepam, are used to treat RLS symptoms, a systematic review done by the American Academy of Sleep Medicine stated that benzodiazepines should not be used as a first-line treatment, although could be used as a coadjuvant therapy...
March 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28303496/three-types-of-a11-neurons-project-to-the-rat-spinal-cord
#3
Hidechika Ozawa, Tsuyoshi Yamaguchi, Shinsuke Hamaguchi, Shigeki Yamaguchi, Shuichi Ueda
The A11 dopaminergic cell group is the only group among the A8-A16 dopaminergic cell groups that includes neurons innervating the spinal cord, and a decrease in dopaminergic transmission at the spinal cord is thought to contribute to the pathogenesis of restless legs syndrome. However, the mechanisms regulating the neuronal activity of A11 dopaminergic neurons remain to be elucidated. Unraveling the neuronal composition, distribution and connectivity of A11 neurons would provide insights into the mechanisms regulating the spinal dopaminergic system...
March 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28285317/efficacy-of-intravenous-iron-sucrose-in-hemodialysis-patients-with-restless-legs-syndrome-rls-a-randomized-placebo-controlled-study
#4
Yinghui Deng, Jinglin Wu, Qiang Jia
BACKGROUND Restless legs syndrome (RLS) is a common disorder in hemodialysis (HD) patients that causes sleep disturbances and diminished quality of life. Because iron deficiency has been implicated in the pathogenesis of RLS, we sought to investigate the effects of intravenous (IV) iron sucrose on symptoms of RLS in HD patients. MATERIAL AND METHODS The study was a randomized, placebo-controlled study of 1000 mg iron sucrose versus normal saline as placebo. Patients were evaluated at baseline and 2 weeks after the last injection...
March 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28283108/higher-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-in-multiple-sclerosis-patients-is-related-to-spinal-cord-lesions
#5
M Minár, D Petrleničová, P Valkovič
BACKGROUND: Multiple sclerosis (MS) is connected with higher prevalence of secondary restless legs syndrome/Willis-Ekbom disease (RLS/WED). Aim of this study was to determine risk factor for developing symptoms of RLS in MS patients. METHODS: In cross-sectional study we examined 200 random MS patients. After obtaining informed consents, patients undervent a structured interview based on RLS and MS symptoms and characteristics, demographic, and health-related data...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28279575/should-oral-iron-be-first-line-therapy-for-pediatric-restless-legs-syndrome-and-periodic-limb-movement-disorder
#6
EDITORIAL
Daniel L Picchietti
No abstract text is available yet for this article.
June 21, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28272118/common-pediatric-pain-disorders-and-their-clinical-associations
#7
Theresa Donnelly, Aneeka Bott, Minh Bui, Shuxiang Goh, Tiina Jaaniste, Cindy Chapman, Matthew Crawford, John L Hopper, David Champion
BACKGROUND: Common childhood pain conditions (non-migraine headache, migraine, recurrent abdominal pain, growing pains, low back pain) and persistent pains are often associated with each other and have significant implications in later life. Emerging evidence suggests additional associations between these pain conditions and restless legs syndrome, iron deficiency, anxiety and depression. The aim of this cross-sectional study in pediatric twin individuals and their siblings was to investigate these associations...
March 7, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28264052/restless-legs-syndrome-augmentation-among-japanese-patients-receiving-pramipexole-therapy-rate-and-risk-factors-in-a-retrospective-study
#8
Masayoshi Takahashi, Shingo Nishida, Masaki Nakamura, Mina Kobayashi, Kentaro Matsui, Eiki Ito, Akira Usui, Yuichi Inoue
To investigate the rate of and risk factors for restless legs syndrome (RLS) augmentation in Japanese patients receiving pramipexole (PPX) treatment. Records of 231 consecutive patients with idiopathic RLS who received PPX therapy for more than one month in a single sleep disorder center were analyzed retrospectively. Augmentation was diagnosed based on the Max Planck Institute criteria; associated factors were identified by logistic regression analysis. Mean age at PPX initiation was 60.6 ± 14.9 years and mean treatment duration was 48...
2017: PloS One
https://www.readbyqxmd.com/read/28252604/-epidemiology-of-sleep-disorders-in-the-republic-of-tatarstan
#9
E Z Yakupov, Y V Troshina, V V Fedorova, L R Hasanshina, L R Ahatova, D V Artemieva
AIM: To evaluate the variability and severity of sleep disorders in people of the Republic of Tatarstan. MATERIAL AND METHODS: A continuous survey using a questionnaire based on the Epworth Sleepiness Scale, the Hospital Anxiety and Depression Scale (HADS), sleep apnea risk scale, restless leg syndrome scale was performed. The survey was conducted in a random sample of people (n=1156). RESULTS AND CONCLUSION: A high level of sleep disorders associated with anxiety disorders and comorbid pathologies was shown...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28244024/-geriatric-inpatients-with-iron-deficiency-associated-restless-legs-syndrome-a-retrospective-analysis
#10
Benjamin Lieske, Gabriele Röhrig, Ingrid Becker, Ralf-Joachim Schulz, Maria Cristina Polidori, Jan Kassubek
OBJECTIVE: The Restless Legs Syndrome (RLS) is a clinically relevant condition in geriatric patients. An association between iron deficiency and RLS is largely acknowledged. The clinical and therapeutic management of iron deficiency-associated RLS has been, however, poorly evaluated in geriatric patients. METHODS: Data from all RLS inpatients admitted to a geriatric unit between 2009 and 2011 were retrospectively collected on demographics and clinical characteristics, iron status, drug treatment including iron substitution, as well as comprehensive geriatric assessment (CGA) scores...
March 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28243925/utility-of-home-sleep-apnea-testing-in-high-risk-veterans
#11
Alyssa Cairns, Kathleen Sarmiento, Richard Bogan
PURPOSE: Many Veterans Affairs Medical Centers (VAMCs) have implemented home sleep apnea testing (HSAT) in lieu of traditional in-lab testing to establish a timely and cost-sensitive diagnosis of obstructive sleep apnea (OSA). However, concern remains for the sensitivity and specificity of said technology in this population as many veterans are at increased risk for many of the comorbid conditions that can limit the accuracy of HSAT results. Hence, the purpose of this study is to evaluate rate of incongruent outcomes (e...
February 27, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28242627/new-concepts-in-the-management-of-restless-legs-syndrome
#12
REVIEW
Diego Garcia-Borreguero, Irene Cano-Pumarega
Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED) is a neurological condition with an overall prevalence in adults of 5-10% in Europe and North America. It is characterised by strong feelings of restlessness and distressing paraesthesia-like sensations in the lower legs, particularly when at rest. The symptoms vary considerably in severity and frequency. RLS/WED has a variable clinical expression influenced by genetic, environmental, and medical factors. Research into the pathophysiology of RLS/WED has found that various genetic markers and existing dysfunctions in dopaminergic mechanisms and iron mechanisms play a central role...
February 27, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28241802/criteria-in-diagnosing-nocturnal-leg-cramps-a-systematic-review
#13
Joannes Hallegraeff, Mathieu de Greef, Wim Krijnen, Cees van der Schans
BACKGROUND: Up to 33% of the general population over 50 years of age are affected by nocturnal leg cramps. Currently there are no generally accepted clinical characteristics, which identify nocturnal leg cramps. This study aims to identify these clinical characteristics and to differentiate between them and the characteristics of restless leg syndrome and periodic limb disorder. METHOD: A systematic literature study was executed from December 2015 to May 2016. This study comprised of a systematic literature review of randomized clinical trials, observational studies on nocturnal and rest cramps of legs and other muscles, and other systematic and narrative reviews...
February 28, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28241358/restless-legs-syndrome
#14
Christopher C Muth
No abstract text is available yet for this article.
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28240944/a-brief-tool-to-differentiate-factors-contributing-to-insomnia-complaints
#15
Donald Townsend, Louis Kazaglis, Kay Savik, Adam Smerud, Conrad Iber
OBJECTIVE: A complaint of insomnia may have many causes. A brief tool examining contributing factors may be useful for nonsleep specialists. This study describes the development of the Insomnia Symptoms Assessment (ISA) for examining insomnia complaints. METHOD: ISA questions were designed to identify symptoms that may represent 1 of 8 possible factors contributing to insomnia symptoms, including delayed sleep phase syndrome (DSPS), shift work sleep disorder (SWSD), obstructive sleep apnea (OSA), mental health, chronic pain, restless leg syndrome (RLS), poor sleep hygiene, and psychophysiological insomnia (PI)...
March 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28236139/iron-dopamine-genetics-and-hormones-in-the-pathophysiology-of-restless-legs-syndrome
#16
REVIEW
Farhan H Khan, Caitlyn D Ahlberg, Christopher A Chow, Divya R Shah, Brian B Koo
Restless legs syndrome (RLS) is a common, chronic neurologic condition, which causes a persistent urge to move the legs in the evening that interferes with sleep. Human and animal studies have been used to study the pathophysiologic state of RLS and much has been learned about the iron and dopamine systems in relation to RLS. Human neuropathologic and imaging studies have consistently shown decreased iron in different brain regions including substantia nigra and thalamus. These same areas also demonstrate a state of relative dopamine excess...
February 24, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28215429/pramipexole-responsive-acute-restless-arms-syndrome-after-surgery-under-general-anesthesia-case-report-and-literature-review
#17
C Dondé, L Peter-Derex, F Pitance, E Cotte, P-M Gonnaud, M Saoud
We reported a case of acute restless arms syndrome occurring after colorectal surgery under general anaesthesia. This case was also compared with other cases of restless legs/arms syndromes occurring in a perioperative context through a literature review. As the restless legs syndrome, the restless arms syndrome can be exacerbated by perioperative procedures and improved with pramipexole from the first day of treatment. This case reinforces the idea that the restless arms syndrome seems to be subsumed along with the restless legs syndrome, and is a further argument to use the diagnosis term "restless limb syndrome" for the restlessness of any limb with clinical features similar to the restless legs syndrome...
February 16, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28215268/periodic-limb-movements-and-restless-legs-syndrome-in-children-with-a-history-of-prematurity
#18
Christopher M Cielo, Lourdes M DelRosso, Ignacio E Tapia, Sarah N Biggs, Gillian M Nixon, Lisa J Meltzer, Joel Traylor, Ji Young Kim, Carole L Marcus
INTRODUCTION: Little is known about the pediatric population at an increased risk of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). Polysomnographic data from the Caffeine for Apnea of Prematurity-Sleep (CAPS) study showed a high prevalence of elevated periodic limb movement index (PLMI) in a cohort of ex-preterm children, but the clinical importance of this finding, such as association with RLS, is unknown. We hypothesized that ex-preterm children would have a high prevalence of RLS and PLMD...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215259/reduced-afferent-induced-facilitation-of-primary-motor-cortex-excitability-in-restless-legs-syndrome
#19
P Bocquillon, C Charley-Monaca, E Houdayer, A Marques, A Kwiatkowski, P Derambure, H Devanne
Restless legs syndrome (RLS) is characterized by the association of an urge to move, and vesperal or nocturnal sensory symptoms; it is frequently associated with periodic limb movements. Evidence from imaging and electrophysiological studies suggests that RLS is linked to changes in sensorimotor integration. Nevertheless, the underlying mechanisms have not been characterized, and the cortical origin has yet to be confirmed. The objective of the present study was to establish whether or not sensorimotor integration in RLS patients is impaired in the evening...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215254/epidemiology-of-sleep-and-sleep-disorders-in-the-netherlands
#20
Gerard A Kerkhof
OBJECTIVE: There is a surging public interest in The Netherlands concerning sleep, sleep disorders and associated health. For a proper perspective, it is necessary to have reliable information on the prevalence of sleep characteristics at the national level. This study set out to assess prevalence rates and key characteristics of sleep and sleep disorders in The Netherlands. METHODS: In 2012, a nationally representative sample of 2089 individuals, aged 18-70 years, responded to a set of 48 questions, including the Holland Sleep Disorders Questionnaire, a validated questionnaire based on the International Classification of Sleep Disorders...
February 2017: Sleep Medicine
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