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https://www.readbyqxmd.com/read/28207868/acetylcholine-versus-cold-pressor-testing-for-evaluation-of-coronary-endothelial-function
#1
Ahmed AlBadri, Janet Wei, Puja K Mehta, Sofy Landes, John W Petersen, R David Anderson, Bruce Samuels, Babak Azarbal, Eileen M Handberg, Quanlin Li, Margo Minissian, Chrisandra Shufelt, Carl J Pepine, C Noel Bairey Merz
BACKGROUND: Assessment of coronary endothelial function with intracoronary acetylcholine (IC-Ach) provides diagnostic and prognostic data in patients with suspected coronary microvascular dysfunction (CMD), but is often not feasible due in part to the time and expertise needed for pharmacologic mixing. Cold pressor testing (CPT) is a simple and safe stimulus useful for either invasive or non-invasive endothelial function testing and myocardial perfusion imaging but has not been specifically evaluated among symptomatic women with signs of ischemic heart disease (IHD) who have no obstructive coronary artery disease (CAD)...
2017: PloS One
https://www.readbyqxmd.com/read/28190958/the-development-and-psychometric-validation-of-an-arabic-language-version-of-the-pain-catastrophizing-scale
#2
Huda Abu-Saad Huijer, Souha Fares, Douglas J French
Context. The Pain Catastrophizing Scale (PCS) is the most widely used measure of pain-specific catastrophizing. Objectives. The purpose of the present study was to develop and psychometrically evaluate an Arabic-language version of the PCS. Methods. In Study 1, 150 adult chronic nonmalignant pain patients seeking treatment at a hospital setting completed the PCS-A and a number of self-report measures assessing clinical parameters of pain, symptoms of depression, and quality of life. Study 2 employed a cold pressor pain task to examine the PCS-A in a sample of 44 healthy university students...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28183818/normalization-of-hemoglobin-based-oxygen-carrier-201-induced-vasoconstriction-roles-of-nitric-oxide-scavenging-and-endothelin
#3
Yannick J Taverne, Daphne P M de Wijs-Meijler, Maaike Te Lintel Hekkert, Paula F Moon-Massat, Greg P Dubé, Dirk Jan Duncker, Daphne Merkus
BACKGROUND: Hemoglobin-based oxygen carrier (HBOC)-201 is a cell-free modified hemoglobin solution potentially facilitating oxygen uptake and delivery in cardiovascular disorders and hemorrhagic shock. Clinical use has been hampered by vasoconstriction in the systemic and pulmonary beds. Therefore we aimed to 1) determine the possibility of counteracting HBOC-201-induced pressor effects with adenosine (ADO), 2) assess the potential roles of nitric oxide (NO) scavenging, reactive oxygen species (ROS) and endothelin (ET) in mediating the observed vasoconstriction and 3) compare these effects in resting and exercising swine...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28179624/analysis-of-beat-to-beat-blood-pressure-variability-response-to-the-cold-pressor-test-in-the-offspring-of-hypertensive-and-normotensive-parents
#4
Dan Wu, Lin Xu, Derek Abbott, William Kongto Hau, Lijie Ren, Heye Zhang, Kelvin K L Wong
Abnormal autonomic nervous regulation has an important role in the development of hypertension. As to whether blood pressure (BP) or BP variability represents the proper characteristics for predisposition to hypertension in Chinese young adults remains controversial. We studied the properties of the indices extracted from beat-to-beat BP during a 13 min cold pressor test (CPT). In this study, 69 Chinese young adults including 34 offspring of hypertensive parents (OHPs; 25.6±2.5 years) and 35 offspring of normotensive parents (ONPs; 25...
February 9, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28174437/the-effects-of-a-pelvic-belt-on-trunk-and-lower-extremity-muscles-in-the-bridge-position
#5
Hyun-Gyu Cha, Yan-Ting Wu, Myoung-Kwon Kim
[Purpose] The purpose of this study was to investigate the effects of a pelvic belt on the activities of trunk and lower extremity muscles in normal adults. [Subjects and Methods] The subjects were 20 normal individuals without a history of orthopedic problems. The pelvic compression belt (The Com-Pressor, OPTP, Minneapolis, MN, USA) was an adjustable body belt with four elastic compression bands that provide stabilizing pressure and was designed to adjust the amount of force applied and to alter sites of compression...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28168774/when-i-get-like-that-put-a-gun-to-my-head
#6
Nancy Lutwak, Curt Dill
Yesterday a 95 year old man with prostate carcinoma and widespread bone metastases was brought to the emergency department because of blood in his urine after he pulled on his foley. At triage he was febrile and hypotensive, moaning incoherently which was not a change in mental status. Despite IV fluid hydration and pressors his blood pressure remained low. This article is protected by copyright. All rights reserved.
February 7, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28162323/-519-the-effect-of-prior-experience-with-cold-pain-on-pain-tolerance-in-the-cold-pressor-task-the-mediating-effect-of-situational-catastrophizing
#7
R Gibler, E Beckmann, C King, K Jastrowski Mano
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161474/the-impact-of-parental-modeling-on-child-pain-responses-the-role-of-parent-and-child-sex
#8
Katelynn E Boerner, Christine T Chambers, Patrick J McGrath, Vincent LoLordo, Rudolf Uher
: Social modeling is a process by which pain behaviours are learned, and research has found parents act as models for their children's behaviour. Despite social learning theory predicting that same-sex models have greater impact, no experimental investigation to date has examined the role of sex of the model or observer in social learning of pediatric pain. The present study recruited 168 parent-child dyads (equal father-son, father-daughter, mother-son, and mother-daughter dyads) where children were generally healthy 6- to 8-year-olds...
February 1, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28150139/acute-effects-of-moderate-continuous-training-on-stress-test-related-pulse-pressure-and-wave-reflection-in-healthy-men
#9
Florian Milatz, Sascha Ketelhut, Reinhard G Ketelhut
INTRODUCTION: Arterial dysfunction develops early in life even in individuals with modest cardiovascular risk. Stress is associated with increased risk in cardiovascular morbidity and mortality. AIM: The main objectives of this study were to investigate the acute effects of moderate continuous training (MCT) on established markers of arterial stiffness and cardiovascular risk during standardized cold pressor stress testing (CPT). METHODS: 29 young healthy male subjects (33...
February 2, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28141635/observer-influences-on-pain-an-experimental-series-examining-same-sex-and-opposite-sex-friends-strangers-and-romantic-partners
#10
Rhiannon Edwards, Christopher Eccleston, Edmund Keogh
Despite well documented sex and gender differences, little is known about the relative impact of male-female social interactions on pain. Three experiments were conducted to investigate whether the type of interpersonal relationship men and women have with an observer affects how they respond to experimental pain. Study 1 recruited friends and strangers, Study 2 examined the effects of same and opposite-sex friends, whereas Study 3 investigated the differences between opposite-sex friends and opposite-sex romantic partners...
January 10, 2017: Pain
https://www.readbyqxmd.com/read/28137984/alkaline-phosphatase-inhibitors-attenuate-renovascular-responses-to-norepinephrine
#11
Edwin K Jackson, Yumeng Zhang, Dongmei Cheng
Tissue nonspecific alkaline phosphatase (TNAP) contributes to the production of adenosine by the kidney, and A1-receptor activation enhances renovascular responses to norepinephrine. Therefore, we hypothesized that TNAP regulates renovascular responsiveness to norepinephrine. In isolated, perfused rat kidneys, the TNAP inhibitor l-p-bromotetramisole (0.1 mmol/L) decreased renal venous levels of 5'-AMP (adenosine precursor) and adenosine by 61% (P<0.0384) and 62% (P=0.0013), respectively, at 1 hour into treatment and caused a 10-fold rightward shift of the concentration-response relationship to exogenous norepinephrine (P<0...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28135808/behavioral-assessment-of-the-negative-emotion-aspect-of-distress-tolerance
#12
Jennifer C Veilleux, Garrett A Pollert, Melissa J Zielinski, Jennifer A Shaver, Morgan A Hill
The current behavioral tasks assessing distress tolerance measure tolerance to frustration and tolerance to physical discomfort, but do not explicitly assess tolerance to negative emotion. We closely evaluated the conceptual distinctions between current behavioral tasks and self-report tasks assessing distress tolerance, and then developed a new behavioral distress tolerance task called the Emotional Image Tolerance (EIT) task. The EIT task retains elements of existing behavioral tasks (e.g., indices of persistence) while augmenting the reliability and content sufficiency of existing measures by including multiple trials, including a variety of negative affect stimuli, and separating overall task persistence from task persistence after onset of distress...
January 1, 2017: Assessment
https://www.readbyqxmd.com/read/28129249/correlation-of-carotid-artery-reactivity-with-cardiovascular-risk-factors-and-coronary-artery-vasodilator-responses-in-asymptomatic-healthy-volunteers
#13
Anke C C M van Mil, Yvonne Hartman, Frederieke van Oorschot, Annemieke Heemels, Nikki Bax, Ellen A Dawson, Nicola Hopkins, Maria T E Hopman, Daniel J Green, David L Oxborough, Dick H J Thijssen
OBJECTIVES: Carotid artery reactivity (CAR%), involving carotid artery diameter responses to a cold pressor test (CPT), is a noninvasive measure of conduit artery function in humans. This study examined the impact of age and cardiovascular risk factors on the CAR% and the relationship between CAR% and coronary artery vasodilator responses to the CPT. METHODS: Ultrasound was used to measure resting and peak carotid artery diameters during the CPT, with CAR% being calculated as the relative change from baseline (%)...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28124117/pain-and-executive-functions-a-unique-relationship-between-stroop-task-and-experimentally-induced-pain
#14
Jovana Bjekić, Marko Živanović, Danka Purić, Joukje M Oosterman, Saša R Filipović
There is a growing body of evidence that a higher level of cognitive inhibition is associated with lower experimental pain sensitivity. However, a systematic examination of the association between executive functions, which include not only inhibition but also updating and shifting, and experimental pain sensitivity is lacking. This study aimed to overcome this limitation by exploring the relationship between a range of executive functions and different measures of experimentally induced cold pain in healthy participants...
January 25, 2017: Psychological Research
https://www.readbyqxmd.com/read/28096689/influence-of-exercise-on-visceral-pain-an-explorative-study-in-healthy-volunteers
#15
Laura Jgm van Weerdenburg, Christina Brock, Asbjørn Mohr Drewes, Harry van Goor, Marjan de Vries, Oliver Hg Wilder-Smith
BACKGROUND AND OBJECTIVES: Contradictory results have been found about the effect of different exercise modalities on pain. The aim of this study was to investigate the early effects of aerobic and isometric exercise on different types of experimental pain, including visceral pain, compared to an active control condition. METHODS: Fifteen healthy subjects (6 women, mean [standard deviation] age 25 [6.5] years) completed 3 interventions consisting of 20 minutes of aerobic cycling, 12 minutes of isometric knee extension and a deep breathing procedure as active control...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28096436/angiotensin-ii-induces-differential-insulin-action-in-rat-skeletal-muscle
#16
Juthamard Surapongchai, Mujalin Prasannarong, Tepmanas Bupha-Intr, Vitoon Saengsirisuwan
Angiotensin II (ANGII) is reportedly involved in the development of skeletal muscle insulin resistance. The present investigation evaluated the effects of two ANGII doses on the phenotypic characteristics of insulin resistance syndrome and insulin action and signaling in rat skeletal muscle. Male Sprague-Dawley rats were infused with either saline (SHAM) or ANGII at a commonly used pressor dose (100 ng/kg/min; ANGII-100) or a higher pressor dose (500 ng/kg/min; ANGII-500) via osmotic minipumps for 14 days. We demonstrated that ANGII-100-infused rats exhibited the phenotypic features of non-obese insulin resistance syndrome, including hypertension, impaired glucose tolerance and insulin resistance of glucose uptake in the soleus muscle, whereas ANGII-500-treated rats exhibited diabetes-like symptoms, such as post-prandial hyperglycemia, impaired insulin secretion and hypertriglyceridemia...
January 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28093011/individuals-with-dark-eyes-and-hair-exhibit-higher-pain-sensitivity
#17
Henrik Holmgaard, Eva Ørsnæs Hansen, Nhung Phuong Thi Dong, Laila Brøns Dixen, Gebbie Ann Rodriguez Nielsen, Jeppe Nørgaard Poulsen, Parisa Gazerani
Emerging evidence suggests that some phenotypic features, such as eye or hair colour, might predict pain. We investigated if light and dark eye and hair colour would influence pain in 60 healthy subjects divided in groups of 15 according to their eye-hair colour and gender. Pressure pain thresholds (PPTs), cold pressor test (CPT), and quality of the perceived pain were assessed. Findings indicated that dark pigmentation phenotype is more sensitive in response to CPT.
January 16, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28091795/mood-spectrum-disorders-and-perception-of-pain
#18
Antonella Ciaramella
: Evaluation of pain perception in chronic pain patients with a concomitant mood-spectrum disorder. DESIGN: The observational retrospective study is based on patient data collected in psychosomatic consultations held at the Gift Institute for Integrative Medicine in Pisa, Italy, from 2002 to 2014. Evoked pain stimulus threshold and tolerance were evaluated using the cold pressor test. Clinical pain intensity and Sensorial, Affective, and Evaluative dimensions were assessed using the Italian Pain Questionnaire, and Anxiety and Depressive symptoms using the Hospital Anxiety Depression Scale...
January 14, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28091707/gastric-distension-causes-changes-in-heart-rate-and-arterial-blood-pressure-by-affecting-the-crosstalk-between-vagal-and-splanchnic-systems-in-anesthetised-rats
#19
Maurizio Sabbatini, Elena Grossini, Claudio Molinari, David A S G Mary, Giovanni Vacca, Mario Cannas
Various hindbrain nuclei have been demonstrated to be involved in the control of the cardiovascular reflexes elicited by both non-noxious and noxious gastric distension, through parasympathetic and sympathetic activation. The different role played by the branches of autonomic nervous system in exerting these effects and their crosstalk in relation to low-/high-pressure distension rate has not been examined yet. Therefore, in the present work, monolateral and bilateral vagotomy and splanchnicotomy were performed in anesthetised rats to analyse the involvement of hindbrain nuclei in haemodynamic changes caused by gastric distension at high (80 mmHg) and low (15 mmHg) pressure...
January 13, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28087254/anti-diabetic-drug-metformin-dilates-retinal-blood-vessels-through-activation-of-amp-activated-protein-kinase-in-rats
#20
Asami Mori, Eriko Ishikawa, Tomoyo Amano, Kenji Sakamoto, Tsutomu Nakahara
The aim of this study was to examine whether metformin, a biguanide anti-hyperglycemic drug, dilates retinal blood vessels in rats. Ocular fundus images were captured with an original high-resolution digital fundus camera in vivo and diameters of retinal blood vessels were measured. Both systemic blood pressure and heart rate were continuously recorded. Metformin (0.01-0.3mg/kg/min) increased diameters of retinal blood vessels in a dose-dependent manner. This retinal vasodilator effect of metformin was abolished by compound C, an inhibitor of AMP-activated protein kinase (AMPK), and N(G)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide (NO) synthase...
January 10, 2017: European Journal of Pharmacology
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