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https://www.readbyqxmd.com/read/29732446/design-synthesis-and-biological-evaluations-of-asymmetric-bow-tie-pamam-dendrimer-based-conjugates-for-tumor-targeted-drug-delivery
#1
Tao Wang, Yaozhong Zhang, Longfei Wei, Yuhan G Teng, Tadashi Honda, Iwao Ojima
A unique asymmetric bow-tie poly(amidoamine) (PAMAM) dendrimer (ABTD) scaffold was designed and developed as a well-defined macromolecular carrier for tumor-targeted drug delivery. The ABTD scaffold in this study consists of a G3-half-dendron (G3-HD) unit and a G1-half-dendron (G1-HD) unit, bearing thiol moiety in each unit and a bis(maleimide) linker unit, which undergo sequential thiol-maleimide coupling to assemble the scaffold. This assembly methodology is applicable to all other combinations of different generations of PAMAM dendrimers...
April 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/29715935/7-5-w-blue-light-generation-at-452-nm-by-internal-frequency-doubling-of-a-continuous-wave-nd-doped-fiber-laser
#2
Baptiste Leconte, Hervé Gilles, Thierry Robin, Benoit Cadier, Mathieu Laroche
We present the first frequency-doubled neodymium-doped fiber laser generating multi-watt CW power near 450 nm. A bow-tie resonator incorporating a LBO nonlinear crystal is integrated within a Nd-doped fiber laser emitting near 900 nm. This scheme achieves an IR to blue conversion efficiency close to 55% without any active control of the internal resonant cavity. As a result, up to 7.5 W of linearly-polarized blue power is generated, with beam quality factors Mx 2 ~1.0 and My 2 ~1.5. A simple numerical model has been developed to optimize and analyse the IR to blue conversion efficiency in the resonant cavity...
April 16, 2018: Optics Express
https://www.readbyqxmd.com/read/29679500/a-unified-material-decomposition-framework-for-quantitative-dual-and-triple-energy-ct-imaging
#3
Wei Zhao, Don Vernekohl, Fei Han, Bin Han, Hao Peng, Yong Yang, Lei Xing, James K Min
PURPOSE: Many clinical applications depend critically on the accurate differentiation and classi-fication of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and applies it, for the first time, in the concept of triple-energy CT (TECT) for enhanced material differentiation and classification as well as dual-energy CT METHODS: We express polychromatic projection into a linear combination of line integrals of material-selective images...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29642646/a-socio-technical-exploration-for-reducing-mitigating-the-risk-of-retained-foreign-objects
#4
Siobhán Corrigan, Alison Kay, Katie O'Byrne, Dubhfeasa Slattery, Sharon Sheehan, Nick McDonald, David Smyth, Ken Mealy, Sam Cromie
A Retained Foreign Object (RFO) is a fairly infrequent but serious adverse event. An accurate rate of RFOs is difficult to establish due to underreporting but it has been estimated that incidences range between 1/1000 and 1/19,000 procedures. The cost of a RFO incident may be substantial and three-fold: (i) the cost to the patient of physical and/or psychological harm; (ii) the reputational cost to an institution and/or healthcare provider; and (iii) the financial cost to the taxpayer in the event of a legal claim...
April 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29610615/surgical-management-of-facial-features-of-robinow-syndrome-a-case-report
#5
Aida M Mossaad, Moustapha A Abdelrahman, Mostafa A Ibrahim, Hatem H Al Ahmady
BACKGROUND: Robinow Syndrome is an extremely rare genetic disorder characterised by abnormalities in head, face and external genitalia. This disorder exists in dominant pattern with moderate symptoms and recessive pattern with more physical and skeletal abnormalities. It was first introduced by Menihard Robinow in 1969. It was related to chromosome 9q22 ROR2 gene related to bone and cartilage growth aspects. CASE PRESENTATION: A 17-year-old Egyptian male presented to National Research Centre Orodental genetics Clinic with typical features of short stature and facial dysmorphism weighted 50 Kg and measured 150 cm height complaining of facial dis figurement...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29609432/upper-lip-tie-wrapping-into-the-hard-palate-and-anterior-premaxilla-causing-alveolar-hypoplasia
#6
Woong Heo, Hee Chang Ahn
Bony anomaly caused by lip tie is not many reported yet. There was a case of upper lip tie wrapping into the anterior premaxilla. We represent a case of severe upper lip tie of limited lip motion, upper lips curling inside, and alveolar hypoplasia. Male patient was born on June 3, 2016. He had a deep philtral sulcus, low vermilion border and deep cupid's bow of upper lip due to tension of short, stout and very tight frenulum. His upper lip motion was severely restricted in particular lip eversion. There was anterior alveolar hypoplasia with deep sulcus in anterior maxilla...
March 2018: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29561875/mine-safety-assessment-using-gray-relational-analysis-and-bow-tie-model
#7
Qingwei Xu, Kaili Xu
Mine safety assessment is a precondition for ensuring orderly and safety in production. The main purpose of this study was to prevent mine accidents more effectively by proposing a composite risk analysis model. First, the weights of the assessment indicators were determined by the revised integrated weight method, in which the objective weights were determined by a variation coefficient method and the subjective weights determined by the Delphi method. A new formula was then adopted to calculate the integrated weights based on the subjective and objective weights...
2018: PloS One
https://www.readbyqxmd.com/read/29452947/highly-stable-molybdenum-dioxide-nanoparticles-with-strong-plasmon-resonance-are-promising-in-photothermal-cancer-therapy
#8
Wei Liu, Xinshi Li, Wentao Li, Qiqi Zhang, Hua Bai, Junfang Li, Guangcheng Xi
Photothermal therapy (PTT) is one of promising cancer therapy with high efficiency and minimal invasiveness. Exploiting of perfect PTT agent is vital to improve the therapy. In this study, a new type of bow tie-like molybdenum dioxide (MoO2 ) nanoparticles was successfully synthesized. These nanobow-ties had strong localized surface plasmon resonance (SPR) effect from visible to near infrared regions, and exhibited ultrahigh chemical stability. They could not only withstand high temperature heating without oxidation, but also resist the corrosion of strong acid and alkali...
May 2018: Biomaterials
https://www.readbyqxmd.com/read/29390701/a-highly-stable-monolithic-enhancement-cavity-for-second-harmonic-generation-in-the-ultraviolet
#9
S Hannig, J Mielke, J A Fenske, M Misera, N Beev, C Ospelkaus, P O Schmidt
We present a highly stable bow-tie power enhancement cavity for critical second harmonic generation (SHG) into the UV using a Brewster-cut β-BaB2 O4 (BBO) nonlinear crystal. The cavity geometry is suitable for all UV wavelengths reachable with BBO and can be modified to accommodate anti-reflection coated crystals, extending its applicability to the entire wavelength range accessible with non-linear frequency conversion. The cavity is length-stabilized using a fast general purpose digital PI controller based on the open source STEMlab 125-14 (formerly Red Pitaya) system acting on a mirror mounted on a fast piezo actuator...
January 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29336347/electromigration-and-morphological-changes-in-ag-nanostructures
#10
A Chatterjee, T Bai, F Edler, C Tegenkamp, K Weide-Zaage, H Pfnür
Electromigration (EM) as a structuring tool was investigated in Ag nanowires (width 300 nm, thickness 25 nm) and partly in notched and bow-tie Ag structures on a Si(1 0 0) substrate in ultra-high vacuum using a four-tip scanning tunneling microscope in combination with a scanning electron microscope. From simulations of Ag nanowires we got estimates of temperature profiles, current density profiles, EM and thermal migration (TM) mass flux distributions within the nanowire induced by critical current densities of 108 A cm-2 ...
February 28, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29300340/constraining-genome-scale-models-to-represent-the-bow-tie-structure-of-metabolism-for-13-c-metabolic-flux-analysis
#11
Tyler W H Backman, David Ando, Jahnavi Singh, Jay D Keasling, Héctor García Martín
Determination of internal metabolic fluxes is crucial for fundamental and applied biology because they map how carbon and electrons flow through metabolism to enable cell function. 13 C Metabolic Flux Analysis ( 13 C MFA) and Two-Scale 13 C Metabolic Flux Analysis (2S- 13 C MFA) are two techniques used to determine such fluxes. Both operate on the simplifying approximation that metabolic flux from peripheral metabolism into central "core" carbon metabolism is minimal, and can be omitted when modeling isotopic labeling in core metabolism...
January 4, 2018: Metabolites
https://www.readbyqxmd.com/read/29210928/retinal-ganglion-cell-topography-in-patients-with-visual-pathway-pathology
#12
Simon Zehnder, Hannes Wildberger, James V M Hanson, Sebastian Lukas, Stefan Pelz, Klara Landau, Werner Wichmann, Christina Gerth-Kahlert
BACKGROUND: To investigate and quantify the impact of intracranial lesions at different locations within the visual pathway on the ganglion cell layer-inner plexiform layer (GCL-IPL) complex and the retinal nerve fiber layer (RNFL). METHODS: Patients with intracranial lesions affecting the optic chiasm (Group I) or the optic tract and/or lateral geniculate nucleus (Group II) were included. All patients received kinetic visual field assessment and underwent spectral domain optical coherence tomography...
November 21, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29105803/a-comparison-of-the-bow-tie-and-stamp-approaches-to-reduce-the-risk-of-surgical-instrument-retention
#13
Maria Mikela Chatzimichailidou, James Ward, Tim Horberry, P John Clarkson
Although relatively rare, surgical instrument retention inside a patient following central venous catheterization still presents a significant risk. The research presented here compared two approaches to help reduce retention risk: Bow-Tie Analysis and Systems-Theoretic Accident Model and Processes. Each method was undertaken separately and then the results of the two approaches were compared and combined. Both approaches produced beneficial results that added to existing domain knowledge, and a combination of the two methods was found to be beneficial...
November 6, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29043094/mid-foot-retinaculum-an-unrecognized-entity
#14
Swathi, Geetha Gangadaran Nellithala, Sunita Arvind Athavale
Retinacula are thickenings of deep fascia in the region of joints that hold down the tendons preventing them from bowing out of position. In the region of ankle, number of such retinacula have been described. Retinacula like superior and inferior extensor retinacula have been described which hold down the tendons of leg muscles passing to the foot beneath them. As the extensor tendons of the leg have more distal attachment to the toes, the present study was conducted to ascertain the presence of any additional retinaculum in the mid-foot region, which would tie down the tendons for their effective action at the distal joints...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28967019/investigation-of-the-role-of-morphology-on-the-magnetic-properties-of-ca-2-mn-3-o-8-materials
#15
Laura J Vera Stimpson, Silvia Ramos, Gavin B G Stenning, Marek Jura, Stephen Parry, Giannantonio Cibin, Donna C Arnold
Ca2 Mn3 O8 exhibits a complex layered structure comprised of Mn3 O8 4- layers separated by Ca2+ ions. In contrast with the more traditional triangular delafossite layered materials the Mn3 O8 4- layers additionally exhibit an ordered vacancy, which forms a 'bow-tie' like arrangement of the Mn4+ ions. We report a comprehensive study of the magnetic properties of a series of Ca2 Mn3 O8 materials with different morphologies. EXAFS and XANES analysis confirm no differences in either manganese environment or oxidation state between materials...
October 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28901617/dual-rotation-c-arm-cone-beam-computed-tomography-to-increase-low-contrast-detection
#16
Aymeric Reshef, Cyril Riddell, Yves Trousset, Saïd Ladjal, Isabelle Bloch
PURPOSE: This paper investigates the capabilities of a dual-rotation C-arm cone-beam computed tomography (CBCT) framework to improve non-contrast-enhanced low-contrast detection for full volume or volume-of-interest (VOI) brain imaging. METHOD: The idea is to associate two C-arm short-scan rotational acquisitions (spins): one over the full detector field of view (FOV) at low dose, and one collimated to deliver a higher dose to the central densest parts of the head...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28796525/quantifying-remote-heating-from-propagating-surface-plasmon-polaritons
#17
Charlotte I Evans, Pavlo Zolotavin, Alessandro Alabastri, Jian Yang, Peter Nordlander, Douglas Natelson
We report a method to electrically detect heating from excitation of propagating surface plasmon polaritons (SPP). The coupling between SPP and a continuous wave laser beam is realized through lithographically defined gratings in the electrodes of thin film gold "bow tie" nanodevices. The propagating SPPs allow remote coupling of optical energy into a nanowire constriction. Heating of the constriction is detectable through changes in the device conductance and contains contributions from both thermal diffusion of heat generated at the grating and heat generated locally at the constriction by plasmon dissipation...
September 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28767643/bow-tie-signaling-in-c-di-gmp-machine-learning-in-a-simple-biochemical-network
#18
Jinyuan Yan, Maxime Deforet, Kerry E Boyle, Rayees Rahman, Raymond Liang, Chinweike Okegbe, Lars E P Dietrich, Weigang Qiu, Joao B Xavier
Bacteria of many species rely on a simple molecule, the intracellular secondary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice: whether to stay in one place and form a biofilm, or to leave it in search of better conditions. The c-di-GMP network has a bow-tie shaped architecture that integrates many signals from the outside world-the input stimuli-into intracellular c-di-GMP levels that then regulate genes for biofilm formation or for swarming motility-the output phenotypes...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28766637/ligand-directed-synthesis-of-mn-twisted-bow-ties
#19
María José Heras Ojea, Moya A Hay, Giacomo Cioncoloni, Gavin A Craig, Claire Wilson, Takuya Shiga, Hiroki Oshio, Mark D Symes, Mark Murrie
Two isostructural polymetallic complexes [Mn(μ3 -O)2 (CH3 COO)4 (L1)4 ]- and [Mn(μ3 -O)2 (CH3 COO)4 (L2)4 ]- have been synthesised by using two Schiff base ligands derived from 3,5-diamino-1,2,4-triazole, following two different preparative routes, either using the pre-formed ligand (for L1) or via a metal-mediated template synthesis (for L2). The {Mn} structure is unusual, being based on two corner-sharing perpendicular {Mn3 } triangles forming a twisted bow-tie. The magnetic studies reveal antiferromagnetic coupling between Mn(iii) ions while electrochemical experiments are consistent with a quasi-reversible Mn(iii)↔Mn(iv) redox process at the central manganese ion...
August 29, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28731722/dynamically-reconfigurable-metadevice-employing-nanostructured-phase-change-materials
#20
Zhihua Zhu, Philip G Evans, Richard F Haglund, Jason G Valentine
Mastering dynamic free-space spectral control and modulation in the near-infrared (NIR) and optical regimes remains a challenging task that is hindered by the available functional materials at high frequencies. In this work, we have realized an efficient metadevice capable of spectral control by minimizing the thermal mass of a vanadium dioxide phase-change material (PCM) and placing the PCM at the feed gap of a bow-tie field antenna. The device has an experimentally measured tuning range of up to 360 nm in the NIR and a modulation depth of 33% at the resonant wavelength...
July 28, 2017: Nano Letters
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