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Darren Mylotte

Sundeep S Kalra, Sami Firoozi, James Yeh, Daniel J Blackman, Shabnam Rashid, Simon Davies, Neil Moat, Miles Dalby, Tito Kabir, Saib S Khogali, Richard A Anderson, Peter H Groves, Darren Mylotte, David Hildick-Smith, Rajiv Rampat, Jan Kovac, Ashan Gunarathne, Jean-Claude Laborde, Stephen J Brecker
OBJECTIVES: The authors present the UK and Irish real-world learning curve experience of the Evolut R transcatheter heart valve. BACKGROUND: The Evolut R is a self-expanding, repositionable, and fully recapturable second-generation transcatheter heart valve with several novel design features to improve outcomes and reduce complications. METHODS: Clinical, procedural, and 30-day outcome data were prospectively collected for the first 264 patients to receive the Evolut R valve in the United Kingdom and Ireland...
February 13, 2017: JACC. Cardiovascular Interventions
Darren Mylotte
No abstract text is available yet for this article.
February 3, 2017: EuroIntervention
Sarah Cuddy, Walentin Kolcow, Yvonne Smyth, Darren Mylotte
No abstract text is available yet for this article.
February 2017: Annals of Emergency Medicine
Darren Mylotte, Nicolo Piazza
No abstract text is available yet for this article.
December 20, 2016: EuroIntervention
Nicolas Debry, Cédric Delhaye, Alexandre Azmoun, Ramzi Ramadan, Sahbi Fradi, Philippe Brenot, Arnaud Sudre, Mouhamed Djahoum Moussa, Didier Tchetche, Said Ghostine, Darren Mylotte, Thomas Modine
OBJECTIVES: The study sought to assess the safety and efficacy of a minimally invasive strategy (MIS) (local anesthesia and conscious sedation) compared to general anesthesia (GA) among the largest published cohort of patients undergoing transcarotid transcatheter aortic valve replacement (TAVR). BACKGROUND: Transcarotid TAVR has been shown to be feasible and safe. There is, however, no information pertaining to the mode anesthesia in these procedures. METHODS: Between 2009 and 2014, 174 patients underwent transcarotid TAVR at 2 French centers...
October 24, 2016: JACC. Cardiovascular Interventions
Pablo Codner, Amos Levi, Giuseppe Gargiulo, Fabien Praz, Kentaro Hayashida, Yusuke Watanabe, Darren Mylotte, Nicolas Debry, Marco Barbanti, Thierry Lefèvre, Thomas Modine, Johan Bosmans, Stephan Windecker, Israel Barbash, Jan-Malte Sinning, Georg Nickenig, Alon Barsheshet, Ran Kornowski
Patients with advanced chronic renal dysfunction were excluded from randomized trials of transcatheter aortic valve replacement (TAVR). The potential impact of chronic renal disease on TAVR prognosis is not fully understood. We aim to evaluate outcomes within a large cohort of patients who underwent TAVR distinguished by renal function. Baseline characteristics, procedural data, and clinical follow-up findings were collected from 10 high-volume TAVR centers in Europe, Israel, and Japan. Data were analyzed according to renal function...
September 15, 2016: American Journal of Cardiology
Nicolo Piazza, Darren Mylotte, Pascal Theriault Lauzier
Interventional cardiologists have traditionally relied upon fluoro-scopic imaging for percutaneous coronary interventions. Transcatheter structural heart interventions, however, require additional imaging modalities such as echocardiography and multislice computed tomography (MSCT) for pre-, intra- and post-procedural assistance. MSCT has emerged as the critical imaging modality for patient and device selection prior to transcatheter structural heart interventions. MSCT is unique as it provides a complete 3-dimensional (3D) dataset of the heart and vasculature that is amenable to multiplanar reconstruction for 2-dimensional (2D) or volume-rendered interpretations...
September 18, 2016: EuroIntervention
Marcus Lee, Thomas Modine, Nicolo Piazza, Darren Mylotte
Individualised, patient-centred care is a central tenet of modern medicine. The variety of transcatheter heart valves currently available affords the opportunity to select the most appropriate device for each individual patient. Prosthesis selection should be based on operator experience and pre-procedural multimodal three-dimensional imaging. Herein, we outline a number of clinical scenarios where specific transcatheter heart valve technologies have the potential to optimise clinical outcome.
September 18, 2016: EuroIntervention
Darren Mylotte, Faisal Sharif, Nicolo Piazza, Marco Moscarelli, Khalil Fattouch, Thomas Modine
No abstract text is available yet for this article.
September 2016: Journal of Geriatric Cardiology: JGC
Gianluca Santise, Saverio Nardella, Stefania Leonetti, Dario Buioni, Bindo Missiroli, Emanuele Di Marzio, Daniele Maselli, Darren Mylotte, Nicolo Piazza, Thomas Modine, Federico De Marco, Andrea Garatti, Luca Testa, Francesco Bedogni
No abstract text is available yet for this article.
July 20, 2016: EuroIntervention
Magdalena Erlebach, Stuart J Head, Darren Mylotte, Martin B Leon, Patrick W Serruys, A Pieter Kappetein, Giuseppe Martucci, Philippe Genereux, Stephan Windecker, Rüdiger Lange, Nicolo Piazza
AIMS: The Valve Academic Research Consortium (VARC) endpoint definitions were established to standardise the reporting of clinical outcomes following transcatheter aortic valve implantation (TAVI). It remains unclear, however, to what extent and in which manner these definitions are applied. Therefore, we sought to investigate the utilisation and adherence to VARC guidelines since their introduction in 2011 across peerreviewed TAVI-related publications. METHODS AND RESULTS: We performed a systematic literature review to identify TAVI-related manuscripts published between February 2011 and February 2014...
June 20, 2016: EuroIntervention
Stuart J Head, Darren Mylotte, Michael J Mack, Nicolo Piazza, Nicolas M van Mieghem, Martin B Leon, A Pieter Kappetein, David R Holmes
In the United States, new surgical heart valves can be approved on the basis of objective performance criteria (OPC). In contrast, the US Food and Drug Administration traditionally requires stricter criteria for transcatheter heart valve (THV) approval, including randomized, clinical trials. Recent US Food and Drug Administration approval of new-generation THVs based on single-arm studies has generated interest in alternative study approaches for THV device approval. This review evaluates whether THV device approval could follow a pathway analogous to that of surgical heart valves by incorporating OPC and provides several considerations and recommendations...
May 24, 2016: Circulation
Darren Mylotte, Arnaud Sudre, Emmanuel Teiger, Jean François Obadia, Marcus Lee, Mark Spence, Hazem Khamis, Arif Al Nooryani, Cedric Delhaye, Gilles Amr, Mohamad Koussa, Nicolas Debry, Nicolo Piazza, Thomas Modine
OBJECTIVES: The purpose of this study was to assess the feasibility and safety of transcarotid transcatheter aortic valve replacement (TAVR). BACKGROUND: Many candidates for TAVR have challenging vascular anatomy that precludes transfemoral access. Transcarotid arterial access may be an option for such patients. METHODS: The French Transcarotid TAVR Registry is a voluntary database that prospectively collected patient demographics, procedural characteristics, and clinical outcomes among patients undergoing transcarotid TAVR...
March 14, 2016: JACC. Cardiovascular Interventions
Nicolo Piazza, Pascal Lauzier, Darren Mylotte
No abstract text is available yet for this article.
February 8, 2016: JACC. Cardiovascular Interventions
Darren Mylotte, Nicolo Piazza, Patrick W Serruys
No abstract text is available yet for this article.
January 22, 2016: EuroIntervention
Pascal Thériault-Lauzier, Magdalena Dorfmeister, Darren Mylotte, Ali Andalib, Marco Spaziano, Philipp Blanke, Giuseppe Martucci, Rüdiger Lange, Jonathon Leipsic, Luc Bilodeau, Nicolo Piazza
AIMS: Transcatheter mitral valve replacement (TMVR) is an emerging technology with the potential to treat patients with mitral regurgitation at excessive risk for mitral valve surgery. Geometrical measurements of the mitral valvular complex may have implications for the design of TMVR devices and for patient selection. This study sought to quantify the dynamic geometry of the mitral valvular complex in patients with significant functional mitral regurgitation (FMR) using multi-slice computed tomography (MSCT)...
October 10, 2016: EuroIntervention
Pascal Thériault-Lauzier, Darren Mylotte, Magdalena Dorfmeister, Marco Spaziano, Ali Andalib, Samuel Mamane, Michael Chetrit, Philipp Blanke, Renzo Cecere, Jean Buithieu, Giuseppe Martucci, Didier Tchetche, Thomas Modine, Nicolas van Mieghem, Rüdiger Lange, Stephan Windecker, Luc Bilodeau, Jonathon Leipsic, Nicolo Piazza
AIMS: Transcatheter mitral valve replacement (TMVR) is an emerging technology with the potential to treat patients with severe mitral regurgitation at excessive risk for surgical mitral valve surgery. Multimodality imaging of the mitral valvular complex and surrounding structures will be an important component for patient selection for TMVR. Our aim was to describe and evaluate a systematic multi-slice computed tomography (MSCT) image analysis methodology that provides measurements relevant for transcatheter mitral valve replacement...
October 10, 2016: EuroIntervention
Darren Mylotte, Nicolo Piazza
In the last year transcatheter mitral valve implantation (TMVI) has seen a major jump in development. This technique offers the potential to treat a great number of elderly and/or high-risk patients with severe mitral regurgitation (MR). Such patients are declined surgical intervention either because the institutional Heart Team considers the risk of intervention to exceed the potential benefit, or because the patients and their families believe the morbidity of mitral surgery to be excessive. The advent of a less invasive transcatheter treatment could, therefore, potentially appeal to both clinicians and patients alike...
September 2015: EuroIntervention
Darren Mylotte, Haytham Makki, Nicolo Piazza
No abstract text is available yet for this article.
August 2015: EuroIntervention
Darren Mylotte, Nicolo Piazza
No abstract text is available yet for this article.
April 2015: Circulation. Cardiovascular Interventions
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