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JOURNAL ARTICLE
Victoria Miller, David A Jenkins, Mahshid Dehghan, Kristie Srichaikul, Sumathy Rangarajan, Andrew Mente, Viswanathan Mohan, Sumathi Swaminathan, Rosnah Ismail, Maria Luz Diaz, Rekha M Ravindran, Katarzyna Zatonska, Ahmad Bahonar, Yuksel Altuntas, Rasha Khatib, Patricio Lopez-Jaramillo, Afzalhussein Yusufali, Karen Yeates, Jephat Chifamba, Romaina Iqbal, Rita Yusuf, Elizabeth Catherina Swart, Hu Bo, Guoliang Han, Xiaocong Li, Khalid F Alhabib, Annika Rosengren, Alvaro Avezum, Fernando Lanas, Salim Yusuf
BACKGROUND: The association between the glycaemic index and the glycaemic load with type 2 diabetes incidence is controversial. We aimed to evaluate this association in an international cohort with diverse glycaemic index and glycaemic load diets. METHODS: The PURE study is a prospective cohort study of 127 594 adults aged 35-70 years from 20 high-income, middle-income, and low-income countries. Diet was assessed at baseline using country-specific validated food frequency questionnaires...
April 5, 2024: Lancet Diabetes & Endocrinology
#2
JOURNAL ARTICLE
Rasha Al-Bawardy, Wael Alqarawi, Jassim Al Suwaidi, Wael Almahmeed, Mohammad Zubaid, Haitham Amin, Kadhim Sulaiman, Ahmad Al-Motarreb, Khalid Alhabib
The use of beta-blockers (BB) in reduced left ventricular ejection fraction (LVEF) post-myocardial infarction (MI) is associated with reduced 1-year mortality, while their role in patients with mid-range and preserved LVEF post-MI remains controversial. We studied 31,620 patients who presented with acute coronary syndrome (ACS) enrolled in seven Arabian Gulf registries between 2005 and 2017. Patients with LVEF ≤40% were excluded. The remaining cohort was divided into two groups: BB group ( n = 15,541) and non-BB group ( n = 2,798), based on discharge medications...
January 16, 2024: Angiology
#3
JOURNAL ARTICLE
Ayman Al Saleh, Amal Jamee, Kadhim Sulaiman, Mohamed Sobhy, Habib Gamra, Fahad Alkindi, Salim Benkhedda, Ahmed Al-Motarreb, Mohammad I Amin, Wael Almahmeed, Ayman Hammoudeh, Hadi Skouri, Hasan A Farhan, Mohammad Al Jarallah, Nadia Fellat, Prashanth Panduranga, Bayan K Alnajm, Magdy Abdelhamid, Rafik Refaat, Hassen Amor, Salma Messaous, Hosameldin S Ahmed, Ahcene Chibane, Azzouz AbdulMalek, Nora K Alsagheer, Sobhi Dada, Zaki Mokhtar, Muhammad Ali, Anhar Ullah, Hanan AlBackr, Khalid F Alhabib
BACKGROUND: The Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa (PEACE MENA) is a prospective registry program in Arabian countries that involves in patients with acute myocardial infarction (AMI) or acute heart failure (AHF). METHODS: This prospective, multi-center, multi-country study is the first report of the baseline characteristics and outcomes of inpatients with AMI who were enrolled during the first 14-month recruitment phase...
2024: PloS One
#4
JOURNAL ARTICLE
Laura AlObaid, Rajesh Rajan, Mohammed Al Jarallah, Raja Dashti, Bassam Bulbanat, Mustafa Ridha, Kadhim Sulaiman, Ibrahim Al-Zakwani, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Nooshin Bazargani, Nidal Asaad, Haitham Amin, Zhanna Kobalava, Peter A Brady, Georgiana Luisa Baca, Ahmad Al-Saber
This study aimed to evaluate the clinical outcomes of patients with acute heart failure (AHF) stratified by mitral regurgitation (MR) in the Arabian Gulf. Patients from the Gulf CARE registry were identified from 47 hospitals in seven Arabian Gulf countries (Yemen, Oman, Kuwait, Qatar, Bahrain, the United Arab Emirates, and Saudi Arabia) from February to November 2012. The cohort was stratified into two groups based on the presence of MR. Univariable and multivariable statistical analyses were performed. The population cohort included 5005 consecutive patients presenting with AHF, of whom 1491 (29...
December 2023: Heliyon
#5
JOURNAL ARTICLE
Turky H Almigbal, Dina S Almunif, Eman Ali Deshisha, Hani Altaradi, Abdullah A Alrasheed, Mohammed A Batais, Khalid F Alhabib
BACKGROUND: Limited reports addressing physicians' understanding of the various low-density lipoprotein cholesterol (LDL-C) targets/statin intensity required for treating the various dyslipidemia patient populations in Saudi Arabia are available. Therefore, the current study assessed the perceptions and beliefs of practicing clinicians in Saudi Arabia regarding the current practice for management of dyslipidemia and potential perceived barriers to adherence to lipid guidelines encountered in their regular clinical practice...
October 2023: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
#6
Khalid Talal Alghamdi, Ghaida Abdullah Albattah, Shoug Saleh Alnasyan, Ali Zaki Alhabib, Alaa Mohammed Noor Samkari, Hussam Yousef Kutub
BACKGROUND: Primary mediastinal B-cell lymphoma (PMBCL) is a subtype of diffuse large B-cell lymphoma that originates from a B cell in the thymus. It usually affects young female. CASE DESCRIPTION: A 30-year-old woman presented with mediastinal mass with history of shortness of breath and chest pain. blood analysis showed low levels of hemoglobin, hematocrit, and mean corpuscular volume and high red cell distribution width. A computed tomography (CT)-guided mediastinal core biopsy disclosed primary mediastinal large B-cell lymphoma (PMLBL) with a nongerminal center phenotype and lung tissue infiltrate...
2023: Surgical Neurology International
#7
JOURNAL ARTICLE
Hanan B Albackr, Khalid Al Waili, Wael Almahmeed, Mohammad Al Jarallah, Mohammad I Amin, Khalid Alrasadi, Mohammed A Batais, Turky H Almigbal, Ali Youssef, Mohammad Alghamdi, Mohammad Al Shehri, Islam Ahmad, Riham A ElToukhy, Naji Kholaif, Abdulhalim J Kinsara, Manal Al-Kindi, Nooshin Barzargani, Magdy Hassan, Shamsa Al Suwaidi, Rajesh Rajan, Hani Altaradi, Khalid F Alhabib
AIM: To assess the current dyslipidemia management in the Arabian Gulf region by describing the demographics, study design, and preliminary results of out-patients who achieved low-density lipoprotein cholesterol (LDL-C) goals at the time of the survey. BACKGROUND: The Arabian Gulf population is at high risk for atherosclerotic cardiovascular disease at younger ages. There is no up-to-date study regarding dyslipidemia management in this region, especially given the recent guideline-recommended LDL-C targets...
July 10, 2023: Current Vascular Pharmacology
#8
JOURNAL ARTICLE
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Martin O'Donnell, Weihong Hu, Gilles Dagenais, Andreas Wielgosz, Scott A Lear, Li Wei, Rafael Diaz, Alvaro Avezum, Patricio Lopez-Jaramillo, Fernando Lanas, Sumathi Swaminathan, Manmeet Kaur, K Vijayakumar, Viswanathan Mohan, Rajeev Gupta, Andrzej Szuba, Romaina Iqbal, Rita Yusuf, Noushin Mohammadifard, Rasha Khatib, Nafiza Mat Nasir, Kubilay Karsidag, Annika Rosengren, Afzalhussein Yusufali, Edelweiss Wentzel-Viljoen, Jephat Chifamba, Antonio Dans, Khalid F Alhabib, Karen Yeates, Koon Teo, Hertzel C Gerstein, Salim Yusuf
AIMS: To develop a healthy diet score that is associated with health outcomes and is globally applicable using data from the Prospective Urban Rural Epidemiology (PURE) study and replicate it in five independent studies on a total of 245 000 people from 80 countries. METHODS AND RESULTS: A healthy diet score was developed in 147 642 people from the general population, from 21 countries in the PURE study, and the consistency of the associations of the score with events was examined in five large independent studies from 70 countries...
July 21, 2023: European Heart Journal
#9
JOURNAL ARTICLE
Hanan AlBackr, Khalid F Alhabib, Kadhim Sulaiman, Amal Jamee, Mohamed Sobhy, Salim Benkhedda, Sobhi Dada, Ayman Hammoudeh, Habib Gamra, Ahmed Al-Motarreb, Fahad Alkindi, Mohammad I Amin, Magdi G Yousif, Hasan A Farhan, Nadia Fellat, Wael Almahmeed, Mohammad Al Jarallah, Prashanth Panduranga, Magdy Abdelhamid, Ihab Ghaly, Dahlia Djermane, Ahcene Chibane, Hadi Skouri, Mohamad Jarrah, Hassen Amor, Nora K Alsagheer, Mohammed A Hozayen, Hosameldin S Ahmed, Muhammad Ali, Anhar Ullah, Ayman Al Saleh, Faiez Zannad
INTRODUCTION: PEACE MENA (Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa) is a prospective registry in Arab countries for in-patients with acute myocardial infarction (AMI) or acute heart failure (AHF). Here, we report the baseline characteristics and outcomes of in-patients with AHF who were enrolled during the first 14 months of the recruitment phase. METHODS: A prospective, multi-centre, multi-country study including patients hospitalized with AHF was conducted...
May 25, 2023: Current Vascular Pharmacology
#10
JOURNAL ARTICLE
Abdulelah H Alsaeed, Ahmed Hersi, Tarek Kashour, Mohammad Zubaid, Jassim Al Suwaidi, Haitham Amin, Wael AlMahmeed, Kadhim Sulaiman, Ahmed Al-Motarreb, Khalid F Alhabib, Wael Alqarawi
INTRODUCTION: The characteristics of young adults with out-of-hospital cardiac arrest (OHCA) due to acute coronary syndrome (ACS) has not been well described. The mean age of gulf citizens in ACS registries is 10-15 years younger than their western counterparts, which provided us with a unique opportunity to investigate the characteristics and predictors of OHCA in young adults presenting with ACS. METHODOLOGY: This was a retrospective cohort study using data from 7 prospective ACS registries in the Gulf region...
2023: PloS One
#11
MULTICENTER STUDY
Philip Joseph, Ambuj Roy, Eva Lonn, Stefan Störk, John Floras, Lisa Mielniczuk, Jean-Lucien Rouleau, Jun Zhu, Anastase Dzudie, Kumar Balasubramanian, Kamilu Karaye, Khalid F AlHabib, Juan Esteban Gómez-Mesa, Kelley R Branch, Abel Makubi, Andrzej Budaj, Alvaro Avezum, Thomas Wittlinger, Georg Ertl, Charles Mondo, Nana Pogosova, Aldo Pietro Maggioni, Andres Orlandini, Alexander Parkhomenko, Ahmed ElSayed, Patricio López-Jaramillo, Alex Grinvalds, Ahmet Temizhan, Camilla Hage, Lars H Lund, Khawar Kazmi, Fernando Lanas, Sanjib Kumar Sharma, Keith Fox, John J V McMurray, Darryl Leong, Hisham Dokainish, Aditya Khetan, Gerald Yonga, Kristian Kragholm, Kerolos Wagdy Shaker, Julius Chacha Mwita, Arif Abudullatif Al Mulla, François Alla, Albertino Damasceno, José Silva-Cardoso, Antonio L Dans, Karen Sliwa, Martin O'Donnell, Nooshin Bazargani, Antoni Bayés-Genís, Tara McCready, Jeffrey Probstfield, Salim Yusuf
IMPORTANCE: Most epidemiological studies of heart failure (HF) have been conducted in high-income countries with limited comparable data from middle- or low-income countries. OBJECTIVE: To examine differences in HF etiology, treatment, and outcomes between groups of countries at different levels of economic development. DESIGN, SETTING, AND PARTICIPANTS: Multinational HF registry of 23 341 participants in 40 high-income, upper-middle-income, lower-middle-income, and low-income countries, followed up for a median period of 2...
May 16, 2023: JAMA
#12
JOURNAL ARTICLE
Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Viswanathan Mohan, Sumathi Swaminathan, Alvaro Avezum, Scott A Lear, Annika Rosengren, Paul Poirier, Fernando Lanas, Patricio Lopez-Jaramillo, Biju Soman, Chuangshi Wang, Andrés Orlandini, Noushin Mohammadifard, Khalid F AlHabib, Jephat Chifamba, Afzal Hussein Yusufali, Romaina Iqbal, Rasha Khatib, Karen Yeates, Thandi Puoane, Yuksel Altuntas, Homer Uy Co, Sidong Li, Weida Liu, Katarzyna Zatońska, Rita Yusuf, Noorhassim Ismail, Victoria Miller, Salim Yusuf
BACKGROUND: Higher intake of ultra-processed foods (UPFs) has been associated with increased risk of CVD and mortality in observational studies from Western countries but data from non-Western countries are limited. OBJECTIVES: We aimed to assess the association between consumption of UPFs and risk of mortality and major CVD in a cohort from multiple world regions. DESIGN: This analysis includes 138,076 participants without a history of CVD between the ages of 35 and 70 y living on 5 continents, with a median follow-up of 10...
January 2023: American Journal of Clinical Nutrition
#13
JOURNAL ARTICLE
Kwadwo Boakye, Marit Bovbjerg, John Schuna, Adam Branscum, Ravi Prasad Varma, Rosnah Ismail, Olga Barbarash, Juan Dominguez, Yuksel Altuntas, Ranjit Mohan Anjana, Rita Yusuf, Roya Kelishadi, Patricio Lopez-Jaramillo, Romaina Iqbal, Pamela Serón, Annika Rosengren, Paul Poirier, P V M Lakshmi, Rasha Khatib, Katarzyna Zatonska, Bo Hu, Lu Yin, Chuangshi Wang, Karen Yeates, Jephat Chifamba, Khalid F Alhabib, Álvaro Avezum, Antonio Dans, Scott A Lear, Salim Yusuf, Perry Hystad
Urbanization may influence physical activity (PA) levels, although little evidence is available for low- and middle- income countries where urbanization is occurring fastest. We evaluated associations between urbanization and total PA, as well as work-, leisure-, home-, and transport-specific PA, for 138,206 adults living in 698 communities across 22 countries within the Prospective Urban and Rural Epidemiology (PURE) study. The 1-week long-form International PA Questionnaire was administered at baseline (2003-2015)...
January 6, 2023: Scientific Reports
#14
JOURNAL ARTICLE
Neeraj Narula, Emily C L Wong, Cara Pray, John K Marshall, Sumathy Rangarajan, Shofiqul Islam, Ahmad Bahonar, Khalid F Alhabib, Anna Kontsevaya, Farnaza Ariffin, Homer U Co, Wadeia Al Sharief, Andrzej Szuba, Andreas Wielgosz, Maria Luz Diaz, Rita Yusuf, Lanthé Kruger, Biju Soman, Yang Li, Chuangshi Wang, Lu Yin, Mirrakhimov Erkin, Fernando Lanas, Kairat Davletov, Annika Rosengren, Patricio Lopez-Jaramillo, Rasha Khatib, Aytekin Oguz, Romaina Iqbal, Karen Yeates, Álvaro Avezum, Walter Reinisch, Paul Moayyedi, Salim Yusuf
BACKGROUND & AIMS: Several medications have been suspected to contribute to the etiology of inflammatory bowel disease (IBD). This study assessed the association between medication use and the risk of developing IBD using the Prospective Urban Rural Epidemiology cohort. METHODS: This was a prospective cohort study of 133,137 individuals between the ages of 20 and 80 from 24 countries. Country-specific validated questionnaires documented baseline and follow-up medication use...
December 15, 2022: Clinical Gastroenterology and Hepatology
#15
JOURNAL ARTICLE
Patricio Lopez-Jaramillo, Diego Gomez-Arbelaez, Daniel Martinez-Bello, Marc Evans M Abat, Khalid F Alhabib, Álvaro Avezum, Olga Barbarash, Jephat Chifamba, Maria L Diaz, Sadi Gulec, Noorhassim Ismail, Romaina Iqbal, Roya Kelishadi, Rasha Khatib, Fernando Lanas, Naomi S Levitt, Yang Li, Viswanathan Mohan, Prem K Mony, Paul Poirier, Annika Rosengren, Biju Soman, Chuangshi Wang, Yang Wang, Karen Yeates, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatonska, Sumathy Rangarajan, Salim Yusuf
BACKGROUND: The triglyceride glucose (TyG) index is an easily accessible surrogate marker of insulin resistance, an important pathway in the development of type 2 diabetes and cardiovascular diseases. However, the association of the TyG index with cardiovascular diseases and mortality has mainly been investigated in Asia, with few data available from other regions of the world. We assessed the association of insulin resistance (as determined by the TyG index) with mortality and cardiovascular diseases in individuals from five continents at different levels of economic development, living in urban or rural areas...
December 12, 2022: The Lancet. Healthy longevity
#16
RANDOMIZED CONTROLLED TRIAL
Mark Loeb, Ambuj Roy, Hisham Dokainish, Antonio Dans, Lia M Palileo-Villanueva, Kamilu Karaye, Jun Zhu, Yan Liang, Fastone Goma, Albertino Damasceno, Khalid F Alhabib, Gerald Yonga, Charles Mondo, Wael Almahmeed, Arif Al Mulla, Vitheya Thanabalan, Purnima Rao-Melacini, Alex Grinvalds, Tara McCready, Shrikant I Bangdiwala, Salim Yusuf
BACKGROUND: Influenza increases the risk of cardiovascular events and deaths. We aimed to see whether influenza vaccination reduces death and vascular events in patients with heart failure. METHODS: We did a pragmatic, randomised, double-blind, placebo-controlled trial in 30 centres (mostly hospitals affliated with universities or a research institute) in ten countries in Asia, the Middle East, and Africa (7 in India, 4 in Philippines, 4 in Nigeria, 6 in China, 1 in Zambia, 2 in Mozambique, 3 in Saudi Arabia, 1 in Kenya, 1 in Uganda, and 1 in Zambia)...
December 2022: Lancet Global Health
#17
JOURNAL ARTICLE
Peter Ludman, Uwe Zeymer, Nicolas Danchin, Petr Kala, Cécile Laroche, Masoumeh Sadeghi, Roberto Caporale, Sameh Mohamed Shaheen, Jacek Legutko, Zaza Iakobishvili, Khalid F Alhabib, Zuzana Motovska, Martin Studencan, Jorge Mimoso, David Becker, Dimitrios Alexopoulos, Zviad Kereseselidze, Sinisa Stojkovic, Parounak Zelveian, Artan Goda, Erkin Mirrakhimov, Gani Bajraktari, Hasan Ali Farhan, Pranas Šerpytis, Bent Raungaard, Toomas Marandi, Alice May Moore, Martin Quinn, Pasi Paavo Karjalainen, Gabriel Tatu-Chitoiu, Chris P Gale, Aldo P Maggioni, Franz Weidinger
AIMS: To use Quality Indicators to study the management of ST segment elevation myocardial infarction (STEMI) in different regions. METHODS AND RESULTS: Prospective cohort study of STEMI within 24 hours of symptom onset (11,462 patients, 196 centres, 26 ESC member and 3 affiliated countries). The median delay between arrival at a PCI centre and primary PCI was 40 min (IQR 20 to 74) with 65.8% receiving PCI within guideline recommendation of 60 min. A third of patients (33...
November 8, 2022: European Heart Journal. Acute Cardiovascular Care
#18
JOURNAL ARTICLE
Marjan Walli-Attaei, Annika Rosengren, Sumathy Rangarajan, Yolandi Breet, Suraya Abdul-Razak, Wadeia Al Sharief, Khalid F Alhabib, Alvaro Avezum, Jephat Chifamba, Rafael Diaz, Rajeev Gupta, Bo Hu, Romaina Iqbal, Rosnah Ismail, Roya Kelishadi, Rasha Khatib, Xinyue Lang, Sidong Li, Patricio Lopez-Jaramillo, Viswanathan Mohan, Aytekin Oguz, Lia M Palileo-Villanueva, Katarzyna Poltyn-Zaradna, Sreelakshmi P R, Lakshmi V M Pinnaka, Pamela Serón, Koon Teo, Sejil T Verghese, Andreas Wielgosz, Karen Yeates, Rita Yusuf, Sonia S Anand, Salim Yusuf
BACKGROUND: There is a paucity of data on the prevalence of risk factors and their associations with incident cardiovascular disease in women compared with men, especially from low-income and middle-income countries. METHODS: In the Prospective Urban Rural Epidemiological (PURE) study, we enrolled participants from the general population from 21 high-income, middle-income, and low-income countries and followed them up for approximately 10 years. We recorded information on participants' metabolic, behavioural, and psychosocial risk factors...
September 10, 2022: Lancet
#19
JOURNAL ARTICLE
Inas Babic, Faten Alsomali, Sana Aljuhani, Sahar Baeissa, Inam Alhabib, Ebtisam AlAhmari, Magdy Omer, Khalid Alkhalifa
Coronavirus disease 2019 (COVID-19) has been increasing among pregnant women worldwide. Its impact on maternal, fetal, and neonatal health is still scarce in the published literature. As a routine COVID-19 prenatal screening has been established for all women requiring hospitalization, it is not clear whether symptomatic women carry worse pregnancy outcomes than those without symptoms. We aimed to analyze perinatal outcomes between symptomatic and asymptomatic women admitted to our center. Materials and Methods ...
2022: Obstetrics and Gynecology International
#20
JOURNAL ARTICLE
Sidong Li, Scott A Lear, Sumathy Rangarajan, Bo Hu, Lu Yin, Shrikant I Bangdiwala, Khalid F Alhabib, Annika Rosengren, Rajeev Gupta, Prem K Mony, Andreas Wielgosz, Omar Rahman, M Y Mazapuspavina, Alvaro Avezum, Aytekin Oguz, Karen Yeates, Fernando Lanas, Antonio Dans, Marc Evans M Abat, Afzalhussein Yusufali, Rafael Diaz, Patricio Lopez-Jaramillo, Lloyd Leach, P V M Lakshmi, Alicja Basiak-Rasala, Romaina Iqbal, Roya Kelishadi, Jephat Chifamba, Rasha Khatib, Wei Li, Salim Yusuf
IMPORTANCE: High amounts of sitting time are associated with increased risks of cardiovascular disease (CVD) and mortality in high-income countries, but it is unknown whether risks also increase in low- and middle-income countries. OBJECTIVE: To investigate the association of sitting time with mortality and major CVD in countries at different economic levels using data from the Prospective Urban Rural Epidemiology study. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study included participants aged 35 to 70 years recruited from January 1, 2003, and followed up until August 31, 2021, in 21 high-income, middle-income, and low-income countries with a median follow-up of 11...
August 1, 2022: JAMA Cardiology
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