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Glasgow prognostic score

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https://www.readbyqxmd.com/read/29228679/prognostic-value-of-the-c-reactive-protein-albumin-ratio-car-in-patients-with-operable-soft-tissue-sarcoma
#1
Yao Liang, Wei Xiao, Yuan-Xiang Guan, Wei Wang, Huo Ying Chen, Cheng Fang, Xing Zhang, Zhi-Wei Zhou
Background: The preoperative C-reactive protein/Albumin ratio (CAR) is valuable for predicting the prognosis of patients with various types of cancers. The aim of the present study is to investigate the prognostic value of the preoperative CAR and compare it with other systemic inflammatory response markers in patients with soft tissue sarcoma (STS). Methods: This retrospective study included 206 patients with STS. The optimal cutoff value of the CAR was determined by receiver operating characteristic (ROC) analysis...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205753/prognostic-significance-of-pre-operative-inflammatory-markers-in-resected-gallbladder-cancer-a-systematic-review
#2
REVIEW
Rukhtam Saqib, Samir Pathak, Neil Smart, Quentin Nunes, Jonathan Rees, Margaret Finch Jones, Graeme Poston
BACKGROUND: Neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP) and Glasgow Prognostic Score (GPS) have demonstrated good prognostic value in several cancers but their role in gallbladder cancer (GBC) remains unclear. The aim of this study is to systematically review the current literature to determine their role in predicting survival outcomes in GBC. METHODS: Using a pre-specified inclusive search strategy MEDLINE, EMBASE and CINAHL databases were used to identify studies describing survival in patients after GBC resection with high or low pre-operative CRP, GPS or NLR...
December 3, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29201763/role-of-clinical-biochemical-and-imaging-parameters-in-predicting-the-severity-of-acute-pancreatitis
#3
Dina Zerem, Omar Zerem, Enver Zerem
Aim: The assessment of the severity of acute pancreatitis (AP) is important for proper management of the disease and for its prognosis. The aim was to correlate clinical, biochemical, and imaging diagnostic parameters and evaluate their prognostic values in the early assessment of severity of AP. Materials and methods: We prospectively studied 128 consecutive patients with AP. The predictors were clinical, biochemical, and imaging diagnostic parameters. The outcome measure was the occurrence of complications...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29196718/the-role-of-the-systemic-inflammatory-response-in-predicting-outcomes-in-patients-with-operable-cancer-systematic-review-and-meta-analysis
#4
Ross D Dolan, Jason Lim, Stephen T McSorley, Paul G Horgan, Donald C McMillan
Cancer remains a leading causes of death worldwide and an elevated systemic inflammatory response (SIR) is associated with reduced survival in patients with operable cancer. This review aims to examine the evidence for the role of systemic inflammation based prognostic scores in patients with operable cancers. A wide-ranging literature review using targeted medical subject headings for human studies in English was carried out in the MEDLINE, EMBASE, and CDSR databases until the end of 2016. The SIR has independent prognostic value, across tumour types and geographical locations...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192354/prognostic-implication-of-inflammation-based-prognostic-scores-in-patients-with-intrahepatic-cholangiocarcinoma-treated-with-first-line-gemcitabine-plus-cisplatin
#5
Hyungwoo Cho, Changhoon Yoo, Kyu-Pyo Kim, Jae Ho Jeong, Jihoon Kang, Heung-Moon Chang, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Sung Koo Lee, Myung-Hwan Kim, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Ju Hyun Shim, Shin Hwang, Gi-Won Song, Deok-Bog Moon, Jae Hoon Lee, Young-Joo Lee, Baek-Yeol Ryoo
Background We aimed to comprehensively evaluate the prognostic value of inflammation-based prognostic scores, including the modified Glasgow Prognostic Score (mGPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR), exclusively in patients with advanced intrahepatic cholangiocarcinoma (iCCA). Methods Between May 2010 and April 2015, 305 patients with histologically documented unresectable or metastatic iCCA were treated with first-line gemcitabine plus cisplatin (GemCis). Among these, 257 patients had complete data for inflammation-based prognostic scores and were included...
December 1, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29178362/the-relationship-between-18f-fdg-petct-derived-markers-of-tumour-metabolism-and-systemic-inflammation-in-patients-with-recurrent-disease-following-surgery-for-colorectal-cancer
#6
Stephen T McSorley, Bo Y Khor, Kwong Tsang, David Colville, Sai Han, Paul G Horgan, Donald C McMillan
AIM: 18 F FDG-PETCT derived markers of tumour metabolism have been reported to have prognostic significance in a variety of tumours. Host inflammation is also recognised to have prognostic significance. The aim of the present study was to investigate the relationship between these markers and host systemic inflammation in patients undergoing elective surgery for colorectal cancer. METHODS: Patients with histologically confirmed colorectal cancer, who underwent elective surgery between 2008 and 2015, who also underwent 18 F FDG-PETCT, at a single centre were included (n =103)...
November 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29175535/application-of-prognostic-scores-in-the-stopah-trial-discriminant-function-is-no-longer-the-optimal-scoring-system-in-alcoholic-hepatitis
#7
Ewan H Forrest, Stephen R Atkinson, Paul Richardson, Steven Masson, Stephen Ryder, Mark R Thursz, Michael Allison
BACKGROUND AND AIMS: 'Static' prognostic models in alcoholic hepatitis (AH), using data from a single time point, include the Discriminant Function (DF), Glasgow Alcoholic Hepatitis Score (GAHS), the Age, Bilirubin, INR and Creatinine (ABIC) score and the Model of End-Stage Liver Disease (MELD).'Dynamic' scores, incorporating evolution of bilirubin at 7 days, include the Lille Score. The aim of this study was to assess these scores' performance in patients from the STOPAH trial. METHODS: Predictive performance of scores was assessed by area under the Receiver Operating Curve (AUC)...
November 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29173768/c-reactive-protein-albumin-ratio-is-an-independent-prognostic-predictor-of-tumor-recurrence-in-stage-iiia-n2-lung-adenocarcinoma-patients
#8
Yoshikane Yamauchi, Seyer Safi, Thomas Muley, Arne Warth, Felix J F Herth, Hendrik Dienemann, Hans Hoffmann, Martin E Eichhorn
OBJECTIVE: To systematically evaluate the prognostic value of nutrition/inflammation-based markers for recurrence-free survival (RFS) in pN2-stage IIIA lung adenocarcinoma patients. MATERIALS AND METHODS: Data from 156 patients who had pathologically confirmed pN2-stage IIIA primary lung adenocarcinoma and received complete surgical resection from 2010 to 2014 were retrospectively analyzed. The data for Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS, C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and prognostic nutritional index were analyzed...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29170303/6%C3%A2-prognostic-value-of-the-glasgow-admission-prediction-score-hospital-length-of-stay-mortality-and-hospital-readmission
#9
Dominic Jones, Allan Cameron, Suzanne Mason, Colin O'Keeffe, David Lowe
INTRODUCTION: As patient numbers presenting to emergency departments (ED) increase, with their myriad of comorbidities, early hospital admission prediction and demand modelling are crucial both in the ED and beyond. The Glasgow admission prediction score (GAPS) (figure 1)1 has already been shown to be accurate in predicting hospital admission from the ED at the point of triage.2 As demand on EDs increase, data driven models such as GAPS will become increasingly important for predicting patient course...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29148861/a-new-approach-for-determining-short-term-objective-prognostic-predictive-methods-for-terminal-cancer-patients-based-on-the-change-point-of-laboratory-test-values
#10
Kazuyuki Niki, Yoshiaki Okamoto, Yoshitaka Tabata, Mamiko Tsugane, Taizo Murata, Masao Mizuki, Yasushi Matsumura, Tatsuya Takagi, Etsuko Uejima
BACKGROUND: In terminal phase cancer, predicting a prognosis precisely plays an important role for patients and their families to live meaningful lives. However, there are no established short-term, objective prognostic predictive methods. OBJECTIVE: To develop simple, short-term, objective prognostic predictive methods through detecting a change point for laboratory test values. DESIGN: A retrospective chart review. SETTING/SUBJECTS: Subjects were cancer patients aged ≥16 years and discharged dead from Osaka University Hospital in 2008...
November 17, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29143568/the-inter-rater-reliability-and-prognostic-value-of-coma-scales-in-nepali-children-with-acute-encephalitis-syndrome
#11
Stephen Ray, Ajit Rayamajhi, Laura J Bonnett, Tom Solomon, Rachel Kneen, Michael J Griffiths
Background Acute encephalitis syndrome (AES) is a common cause of coma in Nepali children. The Glasgow coma scale (GCS) is used to assess the level of coma in these patients and predict outcome. Alternative coma scales may have better inter-rater reliability and prognostic value in encephalitis in Nepali children, but this has not been studied. The Adelaide coma scale (ACS), Blantyre coma scale (BCS) and the Alert, Verbal, Pain, Unresponsive scale (AVPU) are alternatives to the GCS which can be used. Methods Children aged 1-14 years who presented to Kanti Children's Hospital, Kathmandu with AES between September 2010 and November 2011 were recruited...
November 16, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29142183/worse-preoperative-status-based-on-inflammation-and-host-immunity-is-a-risk-factor-for-surgical-site-infections-in-colorectal-cancer-surgery
#12
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
OBJECTIVE: The modified Glasgow Prognostic Score (mGPS) is an inflammation-based measure of malnutrition that reflects a state of cachexia in cancer patients. We evaluated mGPS as an index to predict surgical site infection (SSI) incidence in patients undergoing colorectal cancer surgery. SUBJECTS AND METHODS: We retrospectively analyzed 351 patients who underwent colon cancer resection. Factors correlated with the incidence of SSIs were identified by logistic analysis and stepwise selection...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29141794/short-term-outcome-of-adem-results-from-a-retrospective-cohort-study-from-south-india
#13
Mary Iype, P A Mohammed Kunju, Geetha Saradakutty, T S Anish, Mini Sreedharan, Shahanaz M Ahamed
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM), an immune mediated inflammatory disease is common in children. The profile and immediate outcome of children hospitalized with ADEM is scarce in the available literature. OBJECTIVES: We aimed to study the clinical profile of children with ADEM and to look for prognostic factors for outcome at discharge from hospital METHODS: We chose a retrospective cohort study of all children diagnosed with ADEM at our institution between January 2006 and December 2015, and they were evaluated, after excluding other diagnoses when they were summoned for a follow up visit...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29140952/-don-t-lose-hope-early-hemorrhagic-diffuse-axonal-injury-on-head-ct-is-not-associated-with-poor-outcome-in-moderate-severe-tbi-patients
#14
Nils Henninger, Rebecca A Compton, Muhammad W Khan, Raphael Carandang, Wiley Hall, Susanne Muehlschlegel
BACKGROUND: Diffuse axonal injury (DAI) on MRI has been associated with poor functional outcome after moderate-severe traumatic brain injury (msTBI). Yet, DAI assessment with highly-sensitive MRI-techniques is unfeasible in the acute trauma setting, and CT remains the key diagnostic modality despite its lower sensitivity. We sought to determine whether CT-defined-hemorrhagic-DAI (hDAI) is associated with discharge and favorable 3-and 12-month functional outcome (Glasgow Outcome Score ≥4) after msTBI...
November 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29138578/prognostic-value-of-the-c-reactive-protein-to-albumin-ratio-a-novel-inflammation-based-prognostic-indicator-in-osteosarcoma
#15
Yong-Jiang Li, Kai Yao, Min-Xun Lu, Wen-Biao Zhang, Cong Xiao, Chong-Qi Tu
The prognostic role of the C-reactive protein to albumin ratio (CRP/Alb ratio) in patients with osteosarcoma has not been investigated. A total of 216 osteosarcoma patients were enrolled in the study. Univariate and multivariate survival analyses between the groups were performed and Kaplan-Meier analysis was conducted to plot the survival curves. Receiver operating characteristic curves were generated and areas under the curve (AUCs) were compared to assess the discriminatory ability of the inflammation-based indicators, including CRP/Alb ratio, Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29137064/clinical-features-and-prognostic-factors-in-patients-with-intraventricular-hemorrhage-caused-by-ruptured-arteriovenous-malformations
#16
Zengpanpan Ye, Xiaolin Ai, Xin Hu, Fang Fang, Chao You
Intraventricular hemorrhage (IVH) was associated with poor outcomes in patients with intracerebral hemorrhage. IVH had a high incidence in patients with ruptured arteriovenous malformations (AVMs). In this study, we aimed to discuss the clinical features and prognostic factors of outcomes in the patients with AVM-related IVH.From January 2010 to January 2016, we collected the data of the patients with AVM-related IVH retrospectively. The data, including clinical and radiological parameters, were collected to evaluate the clinical features...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29113530/time-course-of-compromised-urea-synthesis-in-patients-with-alcoholic-hepatitis
#17
Emilie Glavind, Niels Kristian Aagaard, Henning Gronbaek, Nikolaj Worm Orntoft, Hendrik Vilstrup, Karen Louise Thomsen
OBJECTIVES: Alcoholic hepatitis (AH) markedly decreases the urea synthesis capacity. We aimed to investigate the time course of this compromised essential liver function in patients with AH and its relation to treatment and survival. MATERIALS AND METHODS: Thirty patients with AH were included in a prospective cohort study. We measured the substrate-independent urea synthesis capacity, i.e., the functional hepatic nitrogen clearance (FHNC), in the patients at study entry and again at three months (survivors/available: n = 17)...
November 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29111787/performance-status-prognostic-scoring-and-parenteral-nutrition-requirements-predict-survival-in-patients-with-advanced-cancer-receiving-home-parenteral-nutrition
#18
Niamh Keane, Konstantinos C Fragkos, Pinal S Patel, Friderike Bertsch, Shameer J Mehta, Simona Di Caro, Farooq Rahman
We describe a cohort of Home Parenteral Nutrition (HPN) patients with advanced cancer in order to identify factors affecting prognosis. Demographic, anthropometric, biochemical and medical factors, Karnofsky Performance Status (KPS), Glasgow Prognostic Score (GPS), and PN requirements were recorded. Univariate and multivariate analyses were performed including Kaplan-Meier curves, Cox Regression, and correlation analyses. In total, 107 HPN patients (68 women, 39 men, mean age 57 yr) with advanced cancer were identified...
November 7, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29108406/intracerebral-hemorrhage-in-intensive-care-unit-early-prognostication-fallacies-a-single-center-retrospective-study
#19
Stefano Spina, Chiara Marzorati, Alessia Vargiolu, Federico Magni, Matteo Riva, Matteo Rota, Carlo Giussani, Erik P Sganzerla, Giuseppe Citerio
BACKGROUND: Intracerebral hemorrhage (ICH) admitted to intensive care is deem of poor prognosis. To compare observed and predicted 30-days mortality and to evaluate long term functional outcome in a consecutive ICH cohort. METHODS: Retrospective analysis of prospectively collected data of ICH patients managed in a Neuro-ICU from 2012 to 2015. RESULTS: 136 consecutive patients; 34 (25%) had "withholding of life-sustaining treatment" (WLST) order and 102 (75%) received a "full treatment" (FT)...
November 6, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29107348/validation-of-the-modified-glasgow-prognostic-score-mgps-in-recurrent-ovarian-cancer-roc-analysis-of-patients-enrolled-in-the-gcig-symptom-benefit-study-sbs
#20
Felicia T Roncolato, Dominique Berton-Rigaud, Rachel O'Connell, Anne Lanceley, Jalid Sehouli, Luke Buizen, Aikou Okamoto, Eriko Aotani, Domenica Lorusso, Paul Donnellan, Amit Oza, Elisabeth Avall-Lundqvist, Jonathan Berek, Felix Hilpert, Jonathan A Ledermann, Marie Christine Kaminsky, Martin R Stockler, Madeleine T King, Michael Friedlander
BACKGROUND: Modified Glasgow Prognostic Score (mGPS) is predictive of survival in many advanced cancers, but has not been evaluated in recurrent ovarian cancer (ROC). The aim was to determine validity of mGPS in ROC, investigate its associations with health related quality of life (HRQL) and ECOG performance status (PS). METHODS: mGPS is based on serum C reactive protein (CRP) and albumin, with scores ranging from 0 (least) to 2 (most). HRQL was measured with EORTC QLQ C-30 and OV-28...
October 26, 2017: Gynecologic Oncology
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