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Glasgow prognostic score

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https://www.readbyqxmd.com/read/28741220/independent-impact-of-plasma-homocysteine-levels-on-neurological-outcome-following-head-injury
#1
Sivashanmugam Dhandapani, Ankur Bajaj, Chandrasekar Gendle, Inderjeet Saini, Irwanjeet Kaur, Isha Chaudhary, Jasandeep, Jaspinder Kaur, Geetanjali Kalyan, Manju Dhandapani, Sunil K Gupta
Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- and gender-matched controls. Plasma levels of tHcy were measured at admission using direct immunoassay. All the variables were analyzed with respect to tHcy levels and outcome according to Glasgow Outcome Score (GOS) at 3 months...
July 24, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28741195/comparison-of-prognostic-abilities-among-preoperative-laboratory-data-indices-in-patients-with-resectable-gastric-and-esophagogastric-junction-adenocarcinoma
#2
Masayuki Urabe, Hiroharu Yamashita, Toshiaki Watanabe, Yasuyuki Seto
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) are simple indices determined employing laboratory data alone and have been used to predict the clinical outcomes of patients with esophagogastric tumors. However, prior results were generally based on analyzing dichotomous data with arbitrary cutoff values. This retrospective study aims to assess prognostic utilities of preoperative NLR, PLR, LMR, mGPS and PNI, as continuous variables, in gastric cancer (GC) and adenocarcinoma of esophagogastric junction (AEG)...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28740506/comparison-of-inflammation-based-prognostic-scores-in-a-cohort-of-patients-with-resectable-esophageal-cancer
#3
G Jomrich, M Paireder, A Gleiss, I Kristo, L Harpain, S F Schoppmann
BACKGROUND: A number of studies have revealed that inflammation-based prognostic scores, such as Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS), and C-reactive protein and albumin ratio (C/A ratio), are associated with poor outcome in cancer patients. However, until now, no study has investigated the role of these prognostic scores in a cohort of neoadjuvant-treated esophageal adenocarcinomas (nEAC) and squamous cell carcinomas (nESCC). METHODS: Patients had laboratory measurements within three days before resection...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28738126/comparing-plasma-phospho-tau-total-tau-and-phospho-tau-total-tau-ratio-as-acute-and-chronic-traumatic-brain-injury-biomarkers
#4
Richard Rubenstein, Binggong Chang, John K Yue, Allen Chiu, Ethan A Winkler, Ava M Puccio, Ramon Diaz-Arrastia, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, Wayne A Gordon, David O Okonkwo, Peter Davies, Sanjeev Agarwal, Fan Lin, George Sarkis, Hamad Yadikar, Zhihui Yang, Geoffrey T Manley, Kevin K W Wang, Shelly R Cooper, Kristen Dams-O'Connor, Allison J Borrasso, Tomoo Inoue, Andrew I R Maas, David K Menon, David M Schnyer, Mary J Vassar
Importance: Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. Objective: To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI...
July 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28733646/prognostic-role-of-glasgow-prognostic-score-in-patients-with-colorectal-cancer-evidence-from-population-studies
#5
Yangyang Liu, Xingkang He, Jie Pan, Shujie Chen, Liangjing Wang
Glasgow prognostic score (GPS) has been reported to be an indicator of prognosis for various cancers. However, the relationship between GPS and colorectal cancers (CRC) remains unclear. A comprehensive search of Pubmed, Embase, Cochrane library, Web of Science, ChinaInfo and Chinese National Knowledge Infrastructure was performed to identify eligible studies, from which the risk of overall survival (OS) and cancer-specific survival (CSS) were extracted. A random-effect model was adopted to combine hazard ratio (HR) and 95% confidence interval (CI)...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732652/correlation-of-tenascin-c-concentrations-in-serum-with-outcome-of-traumatic-brain-injury-in-humans
#6
Yuan-Yuan Zhao, Lin Lou, Kai-Chuang Yang, Hai-Bo Wang, Yan Xu, Gang Lu, Hai-Yan He
BACKGROUND: Tenascin-C, a matricellular protein, is involved in brain injury. However, change of tenascin-C concentrations in peripheral blood remains unknown after traumatic brain injury (TBI). METHODS: Serum tenascin-C concentrations were measured in 100 healthy controls, 108 severe TBI patients, 79 moderate TBI patients and 32 mild TBI patients. RESULTS: Serum tenascin-C concentrations of patients were significantly higher than those of controls...
July 18, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28731937/an-adapted-clavien-dindo-scoring-system-in-trauma-as-a-clinically-meaningful-nonmortality-endpoint
#7
David N Naumann, Laura E Vincent, Nicola Pearson, Alastair Beaven, Iain M Smith, Kieran Smith, Emma Toman, Helen R Dorrance, Keith Porter, Charles E Wade, Bryan A Cotton, John B Holcomb, Mark J Midwinter
BACKGROUND: There is no consensus on reporting nonmortality trauma complications in a graded manner. The Clavien-Dindo scale of complications was originally for elective surgery and requires adaptation to provide meaningful data for trauma patients. In particular, the original score does not account for those treated without surgery. We report an adapted Clavien-Dindo in trauma (ACDiT) scale and apply it to patients managed operatively and nonoperatively. METHODS: A combined prospective and retrospective international multicenter observational study was undertaken to apply the ACDiT scale to 484 trauma patients at three university teaching hospitals (Birmingham, England (n = 303); Houston, Texas (n = 113); and Glasgow, Scotland (n = 68))...
August 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28729767/glasgow-prognostic-score-after-concurrent-chemoradiotherapy-is-a-prognostic-factor-in-advanced-head-and-neck-cancer
#8
Pei-Hung Chang, Cheng-Hsu Wang, Eric Yen-Chao Chen, Shih-Wei Yang, Wen-Chi Chou, Jason Chia-Hsun Hsieh, Feng-Che Kuan, Kun-Yun Yeh
OBJECTIVE: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). METHODS: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28727832/neurosurgeon-academic-impact-is-associated-with-clinical-outcomes-after-clipping-of-ruptured-intracranial-aneurysms
#9
Naif M Alotaibi, George M Ibrahim, Justin Wang, Daipayan Guha, Muhammad Mamdani, Tom A Schweizer, R Loch Macdonald
BACKGROUND: Surgeon-dependent factors such as experience and volume are associated with patient outcomes. However, it is unknown whether a surgeon's research productivity could be related to outcomes. The main aim of this study is to investigate the association between the surgeon's academic productivity and clinical outcomes following neurosurgical clipping of ruptured aneurysms. METHODS: We performed a post-hoc analysis of 3567 patients who underwent clipping of ruptured intracranial aneurysms in the randomized trials of tirilazad mesylate from 1990 to 1997...
2017: PloS One
https://www.readbyqxmd.com/read/28717855/esophageal-stenosis-and-the-glasgow-prognostic-score-as-independent-factors-of-poor-prognosis-for-patients-with-locally-advanced-unresectable-esophageal-cancer-treated-with-chemoradiotherapy-exploratory-analysis-of-jcog0303
#10
Tatsuya Okuno, Masashi Wakabayashi, Ken Kato, Masayuki Shinoda, Hiroshi Katayama, Hiroyasu Igaki, Yasuhiro Tsubosa, Takashi Kojima, Hiroshi Okabe, Yusuke Kimura, Tatsuyuki Kawano, Shinichi Kosugi, Yasushi Toh, Hoichi Kato, Kenichi Nakamura, Haruhiko Fukuda, Satoshi Ishikura, Nobutoshi Ando, Yuko Kitagawa
BACKGROUND: The aim of this study was to investigate the possible prognostic factors and predictive accuracy of the Glasgow Prognostic Score (GPS) for patients with unresectable locally advanced esophageal squamous cell carcinoma (LAESCC) treated with chemoradiotherapy. METHODS: One hundred forty-two patients were enrolled in JCOG0303 and assigned to the standard cisplatin and 5-fluorouracil (PF)-radiotherapy (RT) group or the low-dose PF-RT group. One hundred thirty-one patients with sufficient data were included in this analysis...
July 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28704837/hamburg-glasgow-classification-preoperative-staging-by-combination-of-disseminated-tumour-load-and-systemic-inflammation-in-oesophageal-carcinoma
#11
Matthias Reeh, Tarik Ghadban, Faik G Uzunoglu, Michael F Nentwich, Maximilian Bockhorn, Klaus Pantel, Jakob R Izbicki, Yogesh K Vashist
BACKGROUND: The aim of this study was to establish a new preoperative staging classification and evaluate its comparability to the post-operative tumour stage, lymph node invasion and metastasis (TNM) classification. To date, adequate, preoperative staging in patients with oesophageal carcinoma (EC) is still missing but urgently needed. Systemic inflammation and disseminated tumour load have a pivotal role in recurrence and oncological outcome. To improve the clinical staging, we merged the Glasgow Prognostic Score (GPS) and disseminated tumour cells (DTC) into a new sufficient preoperative staging classification, the Hamburg-Glasgow classification (HGC)...
July 13, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28695389/clinicopathological-determinants-of-an-elevated-systemic-inflammatory-response-following-elective-potentially-curative-resection-for-colorectal-cancer
#12
David G Watt, Michelle L Ramanathan, Stephen T McSorley, Killian Walley, James H Park, Paul G Horgan, Donald C McMillan
INTRODUCTION: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer. However, it is not clear which clinicopathological factors are associated with the magnitude of the postoperative SIR. The present study was designed to determine the clinicopathological determinants of the postoperative systemic inflammatory response following colorectal cancer resection. METHODS: Patients with a histologically proven diagnosis of colorectal cancer who underwent elective, potentially curative resection during a period from 1999 to 2013 were included in the study (n = 752)...
July 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28693795/the-role-of-the-systemic-inflammatory-response-in-predicting-outcomes-in-patients-with-advanced-inoperable-cancer-systematic-review-and-meta-analysis
#13
REVIEW
Ross D Dolan, Stephen T McSorley, Paul G Horgan, Barry Laird, Donald C McMillan
INTRODUCTION: Cancer remains a leading cause of death worldwide. While a curative intent is the aim of any surgical treatment many patients either present with or go onto develop disseminated disease requiring systemic anti-cancer therapy with a palliative intent. Given their limited life expectancy appropriate allocation of treatment is vital. It is recognised that systemic chemoradiotherapy may shorten the quality/quantity of life in patients with advanced cancer. It is against this background that the present systematic review and meta-analysis of the prognostic value of markers of the systemic inflammatory response in patients with advanced cancer was conducted...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28693167/glasgow-prognostic-score-predicts-therapeutic-outcome-after-hepatic-resection-for-hepatocellular-carcinoma
#14
Hiroaki Shiba, Takashi Horiuchi, Taro Sakamoto, Kenei Furukawa, Yoshihiro Shirai, Tomonori Iida, Yuki Fujiwara, Koichiro Haruki, Katsuhiko Yanaga
Systemic inflammation, as evidenced by the Glasgow prognostic score (GPS), predicts cancer-specific survival in various cancer types. The aim of this study was to evaluate the significance of the GPS in the therapeutic outcome of the patient following surgical resection for hepatocellular carcinoma. In total, 144 patients underwent surgical resection for hepatocellular carcinoma. For the assessment of systemic inflammatory response using the GPS, patients were classified into three groups: Patients with normal serum albumin (<3...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692523/the-prognosis-factors-for-endovascular-coiling-of-aneurysm-in-patients-with-ruptured-intracranial-aneurysm
#15
Feng Zhang, Peng Li, Chao Zhang, Li Wang, Shan-Quan Jing
BACKGROUND: The spontaneous subarachnoid hemorrhage caused by aneurysm rupture often leads to a variety of complications. Endovascular coiling is effective in the treatment of ruptured intracranial aneurysm. AIM: The authors aim to evaluate the risk factors affecting the prognosis of ruptured intracranial aneurysm in patients who received endovascular coiling treatment successfully. METHODS: The demographic and clinical data including age, gender, blood pressure, blood glucose, Hunt-Hess grade, and Fisher grade at admission, Glasgow outcome scale 3 months after coiling, and the location, size of the aneurysms, coiling methods, and time of intervention were retrospectively reviewed and analyzed...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28688124/impact-of-the-pretreatment-glasgow-prognostic-score-on-treatment-tolerance-toxicities-and-survival-in-patients-with-advanced-head-and-neck-cancer-undergoing-concurrent-chemoradiotherapy
#16
Pei-Hung Chang, Kun-Yun Yeh, Cheng-Hsu Wang, Eric Yen-Chao Chen, Shih-Wei Yang, Jen-Seng Huang, Wen-Chi Chou, Jason Chia-Hsun Hsieh
BACKGROUND: The purpose of this study was to evaluate the impact of the pretreatment Glasgow prognostic score on treatment-related toxicities, tolerance, and survival in patients with advanced head and neck cancers undergoing concurrent chemoradiotherapy (CRT). METHODS: We retrospectively analyzed and compared the clinical characteristics, toxicities, and survival of 143 patients with stages III, IVA, and IVB head and neck cancer treated with concurrent CRT according to their Glasgow prognostic score between 2007 and 2010...
July 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28685088/modified-glasgow-prognostic-score-in-patients-with-small-cell-lung-cancer
#17
Koichi Kurishima, Hiroko Watanabe, Hiroichi Ishikawa, Hiroaki Satoh, Nobuyuki Hizawa
Systemic inflammatory response, which represents the presence of cachexia, is observed often in patients with lung cancer. To evaluate the prognostic significance of the presence of a systemic inflammatory response in small cell lung cancer (SCLC) patients, a retrospective study using modified Glasgow prognostic Score (mGPS) was performed. This score is composed of serum albumin and C-reactive protein levels. All the patients with SCLC who were diagnosed in Tsukuba University Hospital, Tsukuba Medical Center Hospital and Mito Medical Center between April 1999 and July 2016 were included in this study...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28684736/fish-oil-enriched-nutrition-combined-with-systemic-chemotherapy-for-gastrointestinal-cancer-patients-with-cancer-cachexia
#18
Yumiko Shirai, Yoshinaga Okugawa, Asahi Hishida, Aki Ogawa, Kyoko Okamoto, Miki Shintani, Yuki Morimoto, Ryutaro Nishikawa, Takeshi Yokoe, Koji Tanaka, Hisashi Urata, Yuji Toiyama, Yasuhiro Inoue, Motoyoshi Tanaka, Yasuhiko Mohri, Ajay Goel, Masato Kusunoki, Donald C McMillan, Chikao Miki
Despite recent advances in chemotherapy for gastrointestinal cancer, a crucial factor related to poor prognosis is reduced tolerance to chemotherapy induced by cancer cachexia. Fish oil (FO)-derived eicosapentaenoic acid (EPA) modulates inflammation in patients with various malignancies; however, the impact of FO-enriched nutrition as a combined modality therapy on clinical outcomes remains controversial. We systemically analysed chronological changes in biochemical and physiological status using bioelectrical impedance analysis in 128 gastrointestinal cancer patients provided with or without FO-enriched nutrition during chemotherapy...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665250/prognostic-value-of-changes-in-brain-tissue-oxygen-pressure-before-and-after-decompressive-craniectomy-following-severe-traumatic-brain-injury
#19
Santiago T Lubillo, Dácil M Parrilla, José Blanco, Jesús Morera, Jaime Dominguez, Felipe Belmonte, Patricia López, Ismael Molina, Candelaria Ruiz, Francisco J Clemente, Daniel A Godoy
OBJECTIVE In severe traumatic brain injury (TBI), the effects of decompressive craniectomy (DC) on brain tissue oxygen pressure (PbtO2) and outcome are unclear. The authors aimed to investigate whether changes in PbtO2 after DC could be used as an independent prognostic factor. METHODS The authors conducted a retrospective, observational study at 2 university hospital ICUs. The study included 42 patients who were admitted with isolated moderate or severe TBI and underwent intracranial pressure (ICP) and PbtO2 monitoring before and after DC...
June 30, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28656485/controlling-nutritional-status-conut-score-is-a-prognostic-marker-for-gastric-cancer-patients-after-curative-resection
#20
Daisuke Kuroda, Hiroshi Sawayama, Junji Kurashige, Masaaki Iwatsuki, Tsugio Eto, Ryuma Tokunaga, Yuki Kitano, Kensuke Yamamura, Mayuko Ouchi, Kenichi Nakamura, Yoshifumi Baba, Yasuo Sakamoto, Yoichi Yamashita, Naoya Yoshida, Akira Chikamoto, Hideo Baba
BACKGROUND: Controlling Nutritional Status (CONUT), as calculated from serum albumin, total cholesterol concentration, and total lymphocyte count, was previously shown to be useful for nutritional assessment. The current study investigated the potential use of CONUT as a prognostic marker in gastric cancer patients after curative resection. METHODS: Preoperative CONUT was retrospectively calculated in 416 gastric cancer patients who underwent curative resection at Kumamoto University Hospital from 2005 to 2014...
June 27, 2017: Gastric Cancer
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