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Glasgow prognostic score

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https://www.readbyqxmd.com/read/29681434/a-placebo-controlled-phase-ii-study-of-ruxolitinib-in-combination-with-pemetrexed-and-cisplatin-for-first-line-treatment-of-patients-with-advanced-nonsquamous-non-small-cell-lung-cancer-and-systemic-inflammation
#1
Giuseppe Giaccone, Rachel E Sanborn, Saiama N Waqar, Alex Martinez-Marti, Santiago Ponce, Huiling Zhen, Gerard Kennealey, Susan Erickson-Viitanen, Eric Schaefer
BACKGROUND: Dysregulation of the Janus kinase (JAK)/signal transducers and activators of transcription pathway contributes to abnormal inflammatory responses and poor prognosis in non-small-cell lung cancer (NSCLC). We evaluated the JAK1/JAK2 inhibitor ruxolitinib plus pemetrexed/cisplatin first-line in patients with stage IIIB/IV or recurrent nonsquamous NSCLC with systemic inflammation (modified Glasgow prognostic score [mGPS] 1/2). PATIENTS AND METHODS: Part 1 was an open-label, safety run-in, in which we assessed ruxolitinib (15 mg twice daily [b...
March 23, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29675680/a-randomized-double-blind-phase-2-study-of-ruxolitinib-or-placebo-in-combination-with-capecitabine-in-patients-with-advanced-her2-negative-breast-cancer-and-elevated-c-reactive-protein-a-marker-of-systemic-inflammation
#2
Joyce O'Shaughnessy, Angela DeMichele, Cynthia X Ma, Paul Richards, Denise A Yardley, Gail Shaw Wright, Kevin Kalinsky, Ronald Steis, Sami Diab, Gerard Kennealey, Ryan Geschwindt, Wei Jiang, Hope S Rugo
PURPOSE: The Janus-associated kinase (JAK)/signal transducer and activator of transcription pathway is a key regulator of inflammatory signaling, associated with tumorigenesis, cell survival, and progression. This randomized phase 2 trial evaluated the efficacy and safety of the addition of ruxolitinib, a JAK1/JAK2 inhibitor, to capecitabine in patients with HER2-negative advanced breast cancer and high systemic inflammation (modified Glasgow Prognostic Score [mGPS] ≥ 1). METHODS: Patients with ≤ 2 prior chemotherapy regimens for advanced or metastatic disease or hormone receptor-positive patients with disease progression on prior hormonal therapies were randomized 1:1 to 21-day cycles of ruxolitinib (n = 76) or placebo (n = 73) plus capecitabine...
April 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29675071/pediatric-head-injury-a-study-of-403-cases-in-a-tertiary-care-hospital-in-a-developing-country
#3
Abrar Ahad Wani, Arif Hussain Sarmast, Muzaffar Ahangar, Nayil Khursheed Malik, Sarabjit Singh Chhibber, Sajad Hussain Arif, Altaf Umar Ramzan, Bashir Ahmed Dar, Zulfiqar Ali
Introduction: Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse. Aims and Objectives: The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Materials and Methods: Patients with TBI, 18 years or less in age, managed in our Department of Neurosurgery, over a period of 2 years, were studied prospectively...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29670365/prognostic-value-of-platelet-to-lymphocyte-ratio-in-pancreatic-cancer-a-comprehensive-meta-analysis-of-17-cohort-studies
#4
REVIEW
Yongping Zhou, Sijin Cheng, Abdel Hamid Fathy, Haixin Qian, Yongzhao Zhao
Background and aims: Several studies were conducted to explore the prognostic value of platelet-to-lymphocyte ratio (PLR) in pancreatic cancer and have reported contradictory results. This study aims to summarize the prognostic role of PLR in pancreatic cancer. Materials and methods: Embase, PubMed and Cochrane Library were completely searched. The cohort studies focusing on the prognostic role of PLR in pancreatic cancer were eligible. The overall survival (OS) and progression-free survival (PFS) were analyzed...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29651500/outcome-of-endovascular-treatment-for-acute-basilar-artery-occlusion-in-the-modern-era-a-single-institution-experience
#5
Chuanhui Li, Wenbo Zhao, Chuanjie Wu, Shuyi Shang, Jian Chen, Ming Ren, Jiangang Duan, Qingfeng Ma, Guilin Li, Yunzhou Zhang, Hongqi Zhang, Liqun Jiao, Xunming Ji
PURPOSE: The beneficial effect of endovascular treatment (EVT) for patients with acute basilar artery occlusion (ABAO) remains uncertain. The purpose of the present study was to evaluate clinical outcome of EVT for patients with ABAO and analyze prognostic factors of good outcome. METHODS: From our prospectively established database, we reviewed all patients with ABAO receiving EVT during January 2014 to December 2016. Baseline characteristics and outcomes were evaluated...
April 12, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29625409/relationship-of-nutritional-status-and-inflammation-with-survival-in-patients-with-advanced-cancer-in-palliative-care
#6
Marcela Souza Cunha, Emanuelly Varea Maria Wiegert, Larissa Calixto-Lima, Livia Costa Oliveira
OBJECTIVE: This study aimed to evaluate the prognostic value of nutritional and inflammatory status in patients with advanced cancer receiving palliative care. METHODS: The systemic inflammatory response was assessed using the modified Glasgow Prognostic Score (mGPS), and nutritional status was evaluated according to the Patient-Generated Subjective Global Assessment (PG-SGA) in 172 patients evaluated on their first visit in the Palliative Care Unit at the National Cancer Institute in Brazil...
February 8, 2018: Nutrition
https://www.readbyqxmd.com/read/29623156/prognostic-value-of-the-neurological-examination-in-cardiac-arrest-patients-after-therapeutic-hypothermia
#7
Elizabeth A Matthews, Jessica Magid-Bernstein, Evie Sobczak, Angela Velazquez, Cristina Maria Falo, Soojin Park, Jan Claassen, Sachin Agarwal
Objectives: Current prognostication guidelines for cardiac arrest (CA) survivors predate the use of therapeutic hypothermia (TH). The prognostic value and ideal timing of the neurological examination remain unknown in the setting of TH. Design: Patients (N = 291) admitted between 2007 and 2015 to Columbia University intensive care units for TH following CA had neurological examinations performed on days 1, 3, 5, and 7 postarrest. Absent pupillary light response (PLR), absent corneal reflexes (CRs), and Glasgow coma scores motor (GCS-M) no better than extension were considered poor examinations...
April 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29622334/pediatric-major-head-injury-not-a-minor-problem
#8
REVIEW
Aaron N Leetch, Bryan Wilson
Traumatic brain injury is a highly prevalent and devastating cause of morbidity and mortality in children. A rapid, stepwise approach to the traumatized child should proceed, addressing life-threatening problems first. Management focuses on preventing secondary injury from physiologic extremes such as hypoxemia, hypotension, prolonged hyperventilation, temperature extremes, and rapid changes in cerebral blood flow. Initial Glasgow Coma Score, hyperglycemia, and imaging are often prognostic of outcome. Surgically amenable lesions should be evacuated promptly...
May 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29617166/preoperative-verbal-memory-problems-and-their-clinical-prognostic-value-in-meningioma-patients-a-prospective-study
#9
Aistė Pranckevičienė, Vytautas Jurkuvėnas, Vytenis Pranas Deltuva, Arimantas Tamašauskas, Adomas Bunevičius
This study aimed to evaluate clinical utility of The Hopkins Verbal Learning Test-Revised (HVLT-R) for assessment of preoperative memory function in meningioma patients and to investigate prognostic value of memory assessment in predicting outcomes after meningioma excision surgery. A total of 93 meningioma patients were assessed 2-3 days preoperatively using HVLT-R, and EORTC QLQ-30 and QLQ-BN20. Functional outcome at discharge was evaluated using The Glasgow Outcome Scale. A sample of 95 healthy controls was matched to patients according to age, gender, and education...
April 4, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29614364/moderate-traumatic-brain-injury-clinical-characteristics-and-a-prognostic-model-of-12-month-outcome
#10
Cathrine Elisabeth Einarsen, Joukje van der Naalt, Bram Jacobs, Turid Follestad, Kent Gøran Moen, Anne Vik, Asta Kristine Haberg, Toril Skandsen
BACKGROUND: Patients with moderate traumatic brain injury (TBI) are often studied together with patients with severe TBI, even though expected outcome is better. Therefore, we aimed to describe patient characteristics and 12-month outcome, and to develop a prognostic model based on admission data, specifically for patients with moderate TBI. METHODS: Patients with Glasgow Coma Scale score of 9-13 and age ≥16 years were prospectively enrolled in two level I trauma centers in Europe...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29595652/determinants-of-lymph-node-count-and-positivity-in-patients-undergoing-surgery-for-colon-cancer
#11
Ross D Dolan, Stephen T McSorley, Paul G Horgan, Donald C McMillan
Prognosis in colon cancer is based on pathological criteria including TNM staging. However, there are deficiencies in this approach, and the lymph node ratio (LNR) has been proposed to improve the prediction of outcomes. LNR is dependent on optimal retrieval of lymph nodes-lymph node count (LNC). Recent studies have suggested that an elevated preoperative systemic inflammatory response (SIR) was associated with a lower LNC and a higher LNR. However, there are a number of potential confounding factors. The aim of the present study was to examine, in detail, these relationships in a large cohort of patients...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29595449/routine-low-dose-continuous-or-nocturnal-oxygen-for-people-with-acute-stroke-three-arm-stroke-oxygen-supplementation-rct
#12
Christine Roffe, Tracy Nevatte, Jon Bishop, Julius Sim, Cristina Penaloza, Susan Jowett, Natalie Ives, Richard Gray, Phillip Ferdinand, Girish Muddegowda
BACKGROUND: Stroke is a major cause of death and disability worldwide. Hypoxia is common after stroke and is associated with worse outcomes. Oxygen supplementation could prevent hypoxia and secondary brain damage. OBJECTIVES: (1) To assess whether or not routine low-dose oxygen supplementation in patients with acute stroke improves outcome compared with no oxygen; and (2) to assess whether or not oxygen given at night only, when oxygen saturation is most likely to be low, is more effective than continuous supplementation...
March 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29593024/feasibility-of-improving-cerebral-autoregulation-in-acute-intracerebral-haemorrhage-breathe-ich-study-a-protocol-for-an-experimental-interventional-study
#13
Jatinder S Minhas, Ronney B Panerai, Thompson G Robinson
INTRODUCTION: Cerebral autoregulation (CA) is impaired in a multitude of neurological conditions. Increasingly, clinical studies are correlating the nature of this impairment with prognostic markers. In acute intracerebral haemorrhage (ICH), impairment of CA has been associated with worsening clinical outcomes including poorer Glasgow Coma Score and larger haematoma volume. Hypocapnia has been shown to improve CA despite concerns over hypoperfusion and consequent ischaemic risks, and it is therefore hypothesised that hypocapnia (via hyperventilation) in acute ICH may improve CA and consequently clinical outcome...
March 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29582981/predicting-outcomes-after-severe-traumatic-brain-injury-science-humanity-or-both
#14
Kwok M Ho
Predicting long-term outcome after severe traumatic brain injury (TBI) is difficult, but accurate assessment is paramount for both families of the patients and medical decision- making, as well as quality assurance or research purposes. Many important prognostic factors for patients with severe TBI have been identified, but most - if not all - including the Glasgow Coma Score and magnetic resonance imaging are not accurate enough to be used alone to predict patient outcomes. Clinicians should also be wary about how their predictions and decision-making can be affected by heuristics and cognitive biases...
March 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29581844/predictive-value-of-inflammation-based-prognostic-scores-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-cytoreductive-nephrectomy
#15
Hironori Fukuda, Toshio Takagi, Tsunenori Kondo, Satoru Shimizu, Kazunari Tanabe
Inflammation-based prognostic scores are useful for predicting survival in various cancers. Here, we aimed to determine the most useful inflammation-based prognostic score for predicting survival in patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy. We retrospectively analyzed the data of 152 patients who underwent cytoreductive nephrectomy for metastatic renal cell carcinoma between 1986 and 2015. In the multivariate stepwise analysis, the combination of age, Memorial Sloan-Kettering Cancer Center score, histology, sarcomatoid change, clinical nodal stage, brain metastasis, and liver metastasis was a significant predictor for survival (Harrell's concordance index [c-index]: 0...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29581811/lymphocyte-to-monocyte-ratio-and-modified-glasgow-prognostic-score-predict-prognosis-of-lung-adenocarcinoma-without-driver-mutation
#16
Seigo Minami, Shouichi Ihara, Sung-Ho Kim, Suguru Yamamoto, Kiyoshi Komuta
Background: Neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) and modified Glasgow prognostic score (mGPS) are useful prognostic markers based on host-related systemic inflammatory response. They have been shown as independent prognostic biomarkers in various cancers, including non-small cell lung cancer. However, there has been little evidence for a specific population of pulmonary adenocarcinoma without active epidermal growth factor receptor (EGFR) mutation. Methods: We retrospectively reviewed 159 patients who met the following criteria: histologically or cytologically diagnosed adenocarcinoma, confirmed wild-type EGFR, started first-line cytotoxic chemotherapy between July 2007 and March 2017 at our hospital, and c-stage IIIB or IV...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581759/the-value-of-preoperative-glasgow-prognostic-score-and-the-c-reactive-protein-to-albumin-ratio-as-prognostic-factors-for-long-term-survival-in-pathological-t1n0-esophageal-squamous-cell-carcinoma
#17
Xiangyang Yu, Yingsheng Wen, Yongbin Lin, Xuewen Zhang, Yongqiang Chen, Weidong Wang, Gongming Wang, Lanjun Zhang
Plenty of studies have confirmed the prognostic values of inflammation-based prognostic scores in many malignant tumors. In present study, we aim to explore whether these indexes has same prognostic values in patients with stage T1N0 esophageal squamous cell carcinoma (ESCC). The clinicopathological data of 160 consecutive patients with pathological stage T1N0 ESCC from January 2005 to December 2012 were collected retrospectively. As prognostic factors, the inflammation-based prognostic scores, including C-reactive protein (CRP), Glasgow prognostic score (GPS), prognostic index (PI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and CRP to albumin ratio (CAR), were evaluated...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581686/the-charlson-comorbidity-index-as-an-independent-prognostic-factor-in-older-colorectal-cancer-patients
#18
Tetsuro Tominaga, Takashi Nonaka, Hiroaki Takeshita, Masaki Kunizaki, Yorihisa Sumida, Shigekazu Hidaka, Terumitsu Sawai, Takeshi Nagayasu
High-age patients have higher rates of comorbidity that are associated with a poor prognosis. It is important to correctly evaluate their preoperative status to avoid mortality. The aim of this study was to clarify whether the Charlson comorbidity index (CCI) was useful for predicting postoperative outcomes. This retrospective study collected data from 250 consecutive patients over 75 years of age. The CCI takes into account 19 comorbid conditions. Inflammation-based scores, including the Glasgow prognostic score (GPS) and the platelet to lymphocyte ratio (PLR), are other preoperative scoring systems...
February 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29580960/prediction-of-survival-in-accidental-hypothermia-requiring-extracorporeal-life-support-an-individual-patient-data-meta-analysis
#19
Richard S Saczkowski, Doug J A Brown, Riyad B Abu-Laban, Guy Fradet, Costas J Schulze, Nick D Kuzak
BACKGROUND: Extra-corporeal life support (ECLS) is a life-saving intervention for patients with hypothermia induced cardiac arrest or severe cardiovascular instability. However, its application is highly variable due to a paucity of data in the literature to guide practice. Current guidelines and recommendations are based on expert opinion, single case reports, and small case series. Combining all of the published data in a patient-level analysis can provide a robust assessment of the influence of patient characteristics on survival with ECLS...
March 23, 2018: Resuscitation
https://www.readbyqxmd.com/read/29574423/palliative-stenting-for-oesophagogastric-cancer-tumour-and-host-factors-and-prognosis
#20
James Hugh Park, Niall Woodley, Donald C McMillan, Paul Glen
OBJECTIVES: Palliative self-expandable metallic stent (SEMS) insertion is common in patients not suitable for resection of oesophagogastric (OG) cancer. Factors which may determine survival, however, are not clear. The present study examined the relationship between tumour and host factors, including the systemic inflammatory response and survival of patients undergoing palliative SEMS insertion. METHODS: Patients with a diagnosis of OG cancer who were considered suitable for palliative SEMS only without systemic therapy were identified...
March 23, 2018: BMJ Supportive & Palliative Care
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