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https://www.readbyqxmd.com/read/29324725/west-nile-virus-and-other-nationally-notifiable-arboviral-diseases-united-states-2016
#1
Alexis Burakoff, Jennifer Lehman, Marc Fischer, J Erin Staples, Nicole P Lindsey
Arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. West Nile virus (WNV) is the leading cause of domestically acquired arboviral disease in the continental United States (1,2). Other arboviruses, including La Crosse, Powassan, Jamestown Canyon, St. Louis encephalitis, and eastern equine encephalitis viruses, cause sporadic cases of disease and occasional outbreaks. This report summarizes surveillance data reported to CDC for 2016 for nationally notifiable arboviruses...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29321318/viperin-restricts-zika-virus-and-tick-borne-encephalitis-virus-replication-by-targeting-ns3-for-proteasomal-degradation
#2
Christakis Panayiotou, Richard Lindqvist, Chaitanya Kurhade, Kirstin Vonderstein, Jenny Pasto, Karin Edlund, Arunkumar S Upadhyay, Anna K Överby
Flaviviruses are arthropod-borne viruses that constitute a major global health problem, with millions of human infections annually. Their pathogenesis ranges from mild illness to severe manifestations such as hemorrhagic fever and fatal encephalitis. Type I interferons (IFNs) are induced in response to viral infection, and stimulate the expression of interferon-stimulated genes (ISGs), including that encoding viperin (virus-inhibitory protein, endoplasmic reticulum-associated, IFN-inducible), which shows antiviral activity against a broad spectrum of viruses including several flaviviruses...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29297316/a-database-of-human-genes-and-a-gene-network-involved-in-response-to-tick-borne-encephalitis-virus-infection
#3
Elena V Ignatieva, Alexander V Igoshin, Nikolay S Yudin
BACKGROUND: Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever to severe neurological illness. Very little is known about genetic factors predisposing to severe forms of disease caused by TBEV. The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins...
December 28, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29277955/tick-borne-illness-after-transplantation-case-and-review
#4
Tresa Reena Mascarenhas, Randi S Silibovsky, Pooja Singh, Katherine Belden
Tick-borne infections in solid organ transplant recipients are an infrequent and difficult diagnostic challenge owing to multiple routes of acquisition and unusual presentations. A 67-year-old male recipient of a combined liver and kidney transplant presented with recurrent fevers following surgery. Standard microbiologic workup was non-diagnostic. Shortness of breath, confusion, lethargy, and hypotension developed along with progressive anemia, requiring multiple blood transfusions. Workup suggested hemolysis and review of the peripheral smear was diagnostic for Babesia microti infection...
December 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29275872/the-long-term-outcome-of-tick-borne-encephalitis-in-central-europe
#5
Petra Bogovič, Daša Stupica, Tereza Rojko, Stanka Lotrič-Furlan, Tatjana Avšič-Županc, Andrej Kastrin, Lara Lusa, Franc Strle
BACKGROUND: Information on the long-term outcome of tick-borne encephalitis (TBE) is limited. OBJECTIVES: To assess the frequency and severity of post-encephalitic syndrome (PES) at different time points after TBE, and to determine the parameters associated with unfavourable outcome. METHODS: Adult patients diagnosed with TBE in Slovenia in the period 2007-2012 were followed-up for 12 months and also examined 2-7 years after TBE. Each patient was asked to refer a person of similar age without a history of TBE to serve as control...
December 6, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29273895/smear-campaign-misattribution-of-pancytopenia-to-a-tick-borne-illness
#6
Jessica Lee, Soraya Azzawi, Michael J Peluso, Aaron Richterman, Haiyan Ramirez Batlle, Maria A Yialamas
We report the case of a 51-year-old woman presenting with a targetoid rash and pancytopenia after a tick bite. Initial evaluation was notable for severe neutropenia on the complete blood cell count differential, a positive Lyme IgM antibody, and a peripheral blood smear demonstrating atypical lymphocytes. While her pancytopenia was initially attributed to tick-borne illness, peripheral flow cytometry showed 7% myeloblasts, and a bone marrow biopsy confirmed 60% blasts. The patient was ultimately diagnosed with acute myelogenous leukemia, in addition to early, localized Lyme disease...
December 22, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29258802/a-molecular-algorithm-to-detect-and-differentiate-human-pathogens-infecting-ixodes-scapularis-and-ixodes-pacificus-acari-ixodidae
#7
Christine B Graham, Sarah E Maes, Andrias Hojgaard, Amy C Fleshman, Sarah W Sheldon, Rebecca J Eisen
The incidence and geographic range of tick-borne illness associated with Ixodes scapularis and Ixodes pacificus have dramatically increased in recent decades. Anaplasmosis, babesiosis, and Borrelia spirochete infections, including Lyme borreliosis, account for tens of thousands of reported cases of tick-borne disease every year. Assays that reliably detect pathogens in ticks allow investigators and public health agencies to estimate the geographic distribution of human pathogens, assess geographic variation in their prevalence, and evaluate the effectiveness of prevention strategies...
December 10, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29258801/diversity-of-borrelia-spirochetes-and-other-zoonotic-agents-in-ticks-from-kyiv-ukraine
#8
Artem Rogovskyy, Maliha Batool, David C Gillis, Patricia J Holman, Igor V Nebogatkin, Yuliya V Rogovska, Maksym S Rogovskyy
Lyme borreliosis (LB) is caused by tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex. LB is the most prevalent vector-borne illness in Ukraine, but current data on the prevalence of LB pathogens in their tick vector, Ixodes ricinus, are lacking. I. ricinus ticks may also carry Borrelia miyamotoi, an emerging relapsing fever group spirochete that has been implicated in human illness. Despite its zoonotic potential, the prevalence of B. miyamotoi in ticks has not been examined in Ukraine. Similarly, data on the prevalence of other important tick-borne pathogens, Anaplasma phagocytophilum, Babesia spp...
December 15, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29232415/serological-detection-of-tick-borne-relapsing-fever-in-texan-domestic-dogs
#9
Maria D Esteve-Gasent, Chloe B Snell, Shakirat A Adetunji, Julie Piccione
Tick-Borne Relapsing Fever (TBRF) is caused by spirochetes in the genus Borrelia. Very limited information exists on the incidence of this disease in humans and domestic dogs in the United States. The main objective of this study is to evaluate exposure of dogs to Borrelia turicatae, a causative agent of TBRF, in Texas. To this end, 878 canine serum samples were submitted to Texas A&M Veterinary Medical Diagnostic Laboratory from October 2011 to September 2012 for suspected tick-borne illnesses. The recombinant Borrelial antigen glycerophosphodiester phosphodiesterase (GlpQ) was expressed, purified, and used as a diagnostic antigen in both ELISA assays and Immunoblot analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29208659/rapid-diagnosis-of-tick-borne-illnesses-by-use-of-one-step-isothermal-nucleic-acid-amplification-and-bio-optical-sensor-detection
#10
Ji Yeun Kim, Bonhan Koo, ChoongEun Jin, Min Chul Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Shin, Sung-Han Kim
BACKGROUND: Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the most common tick-borne illnesses in South Korea. Early differentiation of SFTS from scrub typhus in emergency departments is essential but difficult because of their overlapping epidemiology, shared risk factors, and similar clinical manifestations. METHODS: We compared the diagnostic performance of one-step isothermal nucleic acid amplification with bio-optical sensor detection (iNAD) under isothermal conditions, which is rapid (20-30 min), with that of real-time PCR, in patients with a confirmed tick-borne illness...
December 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29166863/characterization-of-the-inner-membrane-protein-bb0173-from-borrelia-burgdorferi
#11
Christina M Brock, Manuel Bañó-Polo, Maria J Garcia-Murria, Ismael Mingarro, Maria Esteve-Gasent
BACKGROUND: The bacterial spirochete Borrelia burgdorferi is the causative agent of the most commonly reported arthropod-borne illness in the United States, Lyme disease. A family of proteins containing von Willebrand Factor A (VWFA) domains adjacent to a MoxR AAA+ ATPase have been found to be highly conserved in the genus Borrelia. Previously, a VWFA domain containing protein of B. burgdorferi, BB0172, was determined to be an outer membrane protein capable of binding integrin α3β1...
November 22, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29149281/seroreactivity-to-the-c6-peptide-in-borrelia-miyamotoi-infections-occurring-in-the-northeastern-united-states
#12
Phillip J Molloy, Karen E Weeks, Brittany Todd, Gary P Wormser
Background: There are no Food and Drug Administration (FDA) approved diagnostic tests for Borrelia miyamotoi infection, an emerging tick-borne illness in the United States. The purpose of this study was to evaluate whether the FDA-approved C6 peptide ELISA currently used to diagnose Lyme disease may potentially serve as a diagnostic test for B. miyamotoi infections. Methods: Serum specimens from 30 patients from the Northeastern United States with B. miyamotoi infection established by a polymerase chain reaction assay of a blood specimen were tested using the C6 ELISA...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#13
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050793/anaplasmosis-in-pediatric-patients-case-report-and-review
#14
Vaka K Sigurjonsdottir, Henry M Feder, Gary P Wormser
Human granulocytic anaplasmosis (HGA) is a tick-borne infection, characterized as an acute and sometimes severe febrile illness which may be associated with leukopenia and thrombocytopenia. Most case reports of HGA have been in adults, with only 8 case reports of HGA in children. We add a ninth case of HGA, which occurred in a 5-year-old. The paucity of pediatric HGA case reports maybe because publication bias, or HGA in children is a mild illness and children with HGA are less likely than adults to seek medical care, or the diagnosis of HGA requires a blood draw and adults (versus children) are more likely to get diagnostic testing...
November 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28993284/babesia-microti-infection-and-hemophagocytic-lymphohistiocytosis-in-an-immunocompetent-patient
#15
Shanette A Go, Vania H Phuoc, Sarah E Eichenberg, Zelalem Temesgen, Thomas J Beckman
Babesiosis is a rare and potentially severe tick-borne illness endemic to the Northeastern and upper Midwestern regions of the USA. Hemophagocytic lymphohistiocytosis is an uncommon condition resulting from over-activation of the immune system. The first known case of babesiosis and hemophagocytic lymphohistiocytosis in an immunocompetent patient is reported here.
October 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28975470/infections-of-the-central-nervous-system-in-returning-travelers-and-immigrants
#16
REVIEW
Haley Thompson, Kiran Thakur
PURPOSE OF REVIEW: This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS: Updates on travel vaccine recommendations including vaccine-specific interactions with immunosuppressive agents, advances in Zika virus and dengue virus vaccine development, new diagnostic criteria for neurocysticercosis, updates on treatment approaches for tuberculosis meningitis...
October 3, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28948950/a-mini-review-of-bunyaviruses-recorded-in-india
#17
REVIEW
Pragya D Yadav, Gouri Y Chaubal, Anita M Shete, Devendra T Mourya
Newly emerging and re-emerging viral infections are of major public health concern. Bunyaviridae family of viruses comprises a large group of animal viruses. Clinical symptoms exhibited by persons infected by viruses belonging to this family vary from mild-to-severe diseases i.e., febrile illness, encephalitis, haemorrhagic fever and acute respiratory illness. Several arthropods-borne viruses have been discovered and classified at serological level in India in the past. Some of these are highly pathogenic as the recent emergence and spread of Crimean-Congo haemorrhagic fever virus and presence of antibodies against Hantavirus in humans in India have provided evidences that it may become one of the emerging diseases in this country...
May 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28947798/metagenomic-based-surveillance-of-pacific-coast-tick-dermacentor-occidentalis-identifies-two-novel-bunyaviruses-and-an-emerging-human-ricksettsial-pathogen
#18
Jerome Bouquet, Michael Melgar, Andrea Swei, Eric Delwart, Robert S Lane, Charles Y Chiu
An increasing number of emerging tick-borne diseases has been reported in the United States since the 1970s. Using metagenomic next generation sequencing, we detected nucleic acid sequences from 2 novel viruses in the family Bunyaviridae and an emerging human rickettsial pathogen, Rickettsia philipii, in a population of the Pacific Coast tick, Dermacentor occidentalis in Mendocino County sampled annually from 2011 to 2014. A total of 250 adults of this human-biting, generalist tick were collected from contiguous chaparral and grassland habitats, and RNA from each individually extracted tick was deep sequenced to an average depth of 7...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928417/tick-borne-encephalitis-in-japan-republic-of-korea-and-china
#19
REVIEW
Kentaro Yoshii, Joon Young Song, Seong-Beom Park, Junfeng Yang, Heinz-Josef Schmitt
Tick-borne encephalitis virus (TBEV) causes mild or moderate febrile illness in humans that may progress to encephalitis, leading to severe long-term complications and sometimes death. TBEV is prevalent in the Eurasian continent and has been isolated in China, Japan and Republic of Korea (ROK). The TBEV isolates from Japan are of the Far-Eastern subtype; in ROK, the isolates are of the Western subtype; and all TBEV isolates in China are of the Far-Eastern subtype, except one strain that was identified most recently as the Siberian subtype...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28926079/oklar-feber-hos-patient-med-ms-och-rituximab%C3%A2-behandling-var-neoehrlichios-ny-f%C3%A3-stingburen-infektion-som-%C3%A3-r-sv%C3%A3-r-att-diagnostisera
#20
Arya Dadgar, Anna Grankvist, Lennart Wernbro, Christine Wennerås
Fever of unknown origin in a multiple sclerosis patient on immunomodulatory therapy was due to neoehrlichiosis The emerging tick-borne bacterium Candidatus Neoehrlichia mikurensis is the etiologic agent of neoehrlichiosis, a febrile illness that may be accompanied by vascular complications. Severe cases of neoehrlichiosis have been described in patients with hematologic malignancies and systemic rheumatic diseases. We present the first case of neoehrlichiosis in a patient with multiple sclerosis undergoing rituximab therapy...
September 18, 2017: Läkartidningen
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