keyword
https://read.qxmd.com/read/38195916/a-multi-center-international-study-to-evaluate-the-safety-functional-and-oncological-outcomes-of-irreversible-electroporation-for-the-ablation-of-prostate-cancer
#21
JOURNAL ARTICLE
Kai Zhang, Phillip Stricker, Martin Löhr, Michael Stehling, Michel Suberville, Olivier Cussenot, Luca Lunelli, Chi-Fai Ng, Jeremy Teoh, Pilar Laguna, Jean de la Rosette
BACKGROUND: Irreversible electroporation (IRE) is a novel technique to treat localized prostate cancer with the aim of achieving oncological control while reducing related side effects. We present the outcomes of localized prostate cancer treated with IRE from a multi-center prospective registry. METHODS: Men with histologically confirmed prostate cancer were recruited to receive IRE. All the patients were proposed for prostate biopsy at 1-year post-IRE ablation...
January 9, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38194502/successful-immunotherapy-with-pd-1-iinhibitor-for-advanced-pancreatic-cancer-report-of-two-cases-and-review-of-literature
#22
JOURNAL ARTICLE
Lijie Qiu, Chen Liu, Heping Li
Pancreatic cancer is a highly malignant tumor, and most patients are diagnosed at an advanced stage. Unfortunately, due to the immunosuppressive tumor microenvironment of pancreatic cancer, the benefits of immunotherapy for patients with advanced pancreatic cancer are still unclear. Here, we present two cases of advanced pancreatic cancer being controlled by immunotherapy, with pathological diagnoses of ductal adenocarcinoma and acinar cell carcinoma, respectively. Next-generation sequencing (NGS) of both patients is high tumor mutation burden (tumor mutation burden-High) and microsatellite stable...
January 8, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38193113/liver-tumor-mimics-as-a-potential-translational-framework-for-planning-and-testing-irreversible-electroporation-with-multiple-electrodes
#23
JOURNAL ARTICLE
Adriana Leticia Vera-Tizatl, Regine van der Hee, Jeroen Cornelissen, Claudia Elizabeth Vera-Tizatl, Momen Abayazid, Jurgen J Fütterer
Irreversible electroporation (IRE) has emerged as an appealing non-ionizing, non-thermal ablation therapy, independent of antineoplastic drugs. Limited but successful outcomes in IRE conducted in vivo, in small focal hepatocellular carcinomas (HCC), have been reported. Nonetheless, the electric parameters of IRE are usually delivered in an unplanned manner. This work investigates the integration of computational modeling to hydrogels mimicking the HCC microenvironment, as a powerful framework to: circumvent ethical concerns of in vivo experimentation; safely tune the electric parameters reaching the IRE electric field threshold; and propel the translation of IRE as a routine clinical alternative to the treatment of HCC...
January 2024: Bioengineering & Translational Medicine
https://read.qxmd.com/read/38159790/ultrastructural-insights-from-myocardial-ablation-lesions-from-microsecond-pulsed-field-vs-radiofrequency-energy
#24
JOURNAL ARTICLE
Iwanari Kawamura, Bingyan J Wang, Moritz Nies, Keita Watanabe, Hina W Chaudhry, Yasuhiro Maejima, Tetsuo Sasano, Ronald Gordon, Srinivas R Dukkipati, Vivek Y Reddy, Jacob Koruth
BACKGROUND: Ultrastructural findings immediately after pulsed field ablation (PFA) of the myocardium have not been described. OBJECTIVES: To elucidate ultrastructural characteristics and differences between microsecond PFA at the 1- and 4-hour timepoint after pulse delivery, and to compare them to irrigated radiofrequency ablation (RFA) lesions. METHODS: Healthy swine underwent endocardial PFA or RFA followed by necropsy. Discrete microsecond PFA and irrigated RFA lesions were created in the ventricles with a lattice tip ablation catheter...
December 28, 2023: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38156621/thermal-damage-map-prediction-during-irreversible-electroporation-with-u-net
#25
JOURNAL ARTICLE
Amir Khorasani
Recent developments in cancer treatment with irreversible electroporation (IRE) have led to a renewed interest in developing a treatment planning system based on Deep-Learning methods. This paper will give an account of U-Net, as a Deep-Learning architecture usage for predicting thermal damage area during IRE. In this study, an irregular shape of the liver tumor with MIMICS and 3-Matic software was created from Magnetic Resonance Imaging (MRI) images. To create electric field distribution and thermal damage maps in IRE, COMSOL Multiphysics 5...
December 29, 2023: Electromagnetic Biology and Medicine
https://read.qxmd.com/read/38145519/integrated-time-nanosecond-pulse-irreversible-electroporation-inspire-assessment-of-dose-temperature-and-voltage-on-experimental-and-clinical-treatment-outcomes
#26
JOURNAL ARTICLE
Christopher C Fesmire, Robert H Williamson, Ross A Petrella, Jacob D Kaufman, Nomi Topasna, Michael B Sano
OBJECTIVE: This study sought to investigate a novel strategy using temperature-controlled delivery of nanosecond pulsed electric fields as an alternative to the 50-100 microsecond pulses used for irreversible electroporation. METHODS: INSPIRE treatments were carried out at two temperatures in 3D tumor models using doses between 0.001s and 0.1s. The resulting treatment zones were quantified using viability staining and lethal electric field intensities were determined numerically...
December 25, 2023: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38113160/the-enhancement-of-tumor-ablation-effect-by-the-combination-of-high-frequency-and-low-voltage-bipolar-electroporation-pulses
#27
JOURNAL ARTICLE
Yanpeng Lv, Zhikui Feng, Xuan Liu, Jianhua Zhang, Chenguo Yao
UNLABELLED: The H-FIRE (high-frequency irreversible electroporation) protocol employs high-frequency bipolar pulses (HFBPs) with a width of ∼1 μs for tumor ablation with slight muscle contraction. However, H-FIRE pulses need a higher electric field to generate a sufficient ablation effect, which may cause undesirable thermal damage. OBJECTIVE: Recently, combining short high-voltage IRE monopolar pulses with long low-voltage IRE monopolar pulses was shown to enlarge the ablation region...
December 19, 2023: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38101057/a-rapid-and-efficient-method-using-electroporation-for-releasing-intracellular-microcystin-toxins-from-cultured-and-naturally-occurring-cyanobacterial-cells-in-lake-water
#28
JOURNAL ARTICLE
Yuehan Ai, Paul Bertani, Hao Yang, Seungjun Lee, Wu Lu, Jiyoung Lee
In cyanotoxin measurements, effective release of intracellular cyanotoxins through cell lysis is pivotal. The conventional method for cell lysis is repeated freeze-thaw (F-T), which has several disadvantages, including poor reproducibility since it is operator and equipment dependency and time-consuming. In this study, a rapid and sensitive method was developed using irreversible electroporation, reducing quantification time by over 6 h compared to F-T. Focusing on microcystins (MCs), we developed the most optimal electroporation medium (50 mM Tris (pH 7...
December 13, 2023: Marine Pollution Bulletin
https://read.qxmd.com/read/38087706/image-guided-ablative-procedures
#29
JOURNAL ARTICLE
R Dai, R Uppot, R Arellano, S Kalva
Various image-guided ablative procedures include chemical and thermal ablation techniques and irreversible electroporation. These have been used for curative intent for small tumours and palliative intent for debulking, immunogenicity and pain control. Understanding these techniques is critical to avoiding complications and achieving superior clinical outcomes. Additionally, combination with immunotherapy and chemotherapies is rapidly evolving. There are numerous opportunities in interventional radiology to advance ablation techniques and seamlessly integrate into current treatment regimens for both benign and malignant tumours...
November 23, 2023: Clinical Oncology: a Journal of the Royal College of Radiologists
https://read.qxmd.com/read/38084419/a-side-effect-free-interventional-therapy-for-precisely-eliminating-unresectable-cancer-pain
#30
JOURNAL ARTICLE
Pengfei Zhang, Sheng Yao, Yu Tang, Shanhe Wan, Xiaoyuan Chen, Li Ma
Of patients bearing unresectable tumors at advanced stages, most undergo serious pain. For unresectable tumors adjacent to vital organs or nerves, eliminating local cancer pain without adverse effects remains a formidable challenge. Interventional ablative therapies (IATs), such as radio frequency ablation (RFA), microwave ablation, and irreversible electroporation, have been clinically adopted to treat various carcinomas. In this study, we established another palliative interventional therapy to eliminate local cancer pain, instead of relieving nociception temporarily...
December 12, 2023: ACS Nano
https://read.qxmd.com/read/38059737/optimal-irreversible-electroporation-combined-with-nano-enabled-immunomodulatory-to-boost-systemic-antitumor-immunity
#31
JOURNAL ARTICLE
Wencheng Peng, Yanbing Cao, Yuting Zhang, Aoxue Zhong, Cao Zhang, Zuwu Wei, Xiaolong Liu, Shoulong Dong, Jingcheng Wu, Yanan Xue, Ming Wu, Chenguo Yao
To enhance the efficiency of tumor ablation, we propose the novel pulse configuration nμPEF, which combines both nanosecond and microsecond pulses. This advancement aims to further the potential application of irreversible electroporation (IRE) in oncological therapy. We demonstrated that nμPEF exhibited enhanced efficacy in inducing immunogenic cell death, positioning it as a promising candidate for the next generation of ablative therapy. However, the immune response induced by nμPEF alone was found to be insufficient in effectively suppressing abscopal tumors...
December 7, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/38034109/new-surgical-approach-to-treat-fibroids-and-solid-tumors-thermal-and-nonthermal-ablation
#32
JOURNAL ARTICLE
Wu-Shun Felix Wong
There is a trend toward more minimally invasive treatment for symptomatic uterine fibroids. They are image-guided ablation surgery with focused ultrasound, microwave, and radiofrequency ablations that are becoming tested and used in some medical centers or hospitals. Nevertheless, these image-guided ablation surgeries involve thermal ablation to the fibroids, which might lead to thermal injury to the surrounding tissues, for example, nerve injury, vessel injury, and skin burn due to heat diffusion. A new technology - irreversible electroporation (IRE) - is a new paradigm for treating solid tumors...
2023: Gynecology and Minimally Invasive Therapy
https://read.qxmd.com/read/37998594/sequential-irreversible-electroporation-for-locally-advanced-pancreatic-cancer
#33
JOURNAL ARTICLE
Daniel Yuxuan Ong, Uei Pua
Pancreatic cancer is a lethal disease, with locally advanced pancreatic cancer (LAPC) having a dismal prognosis. For patients with LAPC, gemcitabine-based regimens, with or without radiation, have long been the standard of care. Irreversible electroporation (IRE), a non-thermal ablative technique, may potentially prolong the survival of patients with LAPC. In this article, the authors present a case of LAPC of the uncinate process (biopsy proven pancreatic neuroendocrine carcinoma) with duodenal invasion. The patient had a combination of chemotherapy and radiation therapy but was found to have stable disease...
November 16, 2023: Diagnostics
https://read.qxmd.com/read/37989990/in-silico-study-about-the-influence-of-electroporation-parameters-on-the-cellular-internalization-spatial-uniformity-and-cytotoxic-effects-of-chemotherapeutic-drugs-using-the-method-of-fundamental-solutions
#34
JOURNAL ARTICLE
Fabián Mauricio Vélez Salazar, Iván David Patiño Arcila
Reversible electroporation is a suitable technique to aid the internalization of medicaments in cancer tissues without inducing permanent cellular damage, allowing the enhancement of cytotoxic effects without incurring in electric-driven necrotic or apoptotic processes by the presence of non-reversible aqueous pores. An adequate selection of electroporation parameters acquires relevance to reach these goals and avoid opposite effects. This work applies the Method of Fundamental Solutions (MFS) for drug transport simulations in electroporated cancer tissues, using a continuum tumor cord approach and considering both electro-permeabilization and vasoconstriction effects...
November 21, 2023: Medical & Biological Engineering & Computing
https://read.qxmd.com/read/37989902/harnessing-the-electrochemical-effects-of-electroporation-based-therapies-to-enhance-anti-tumor-immune-responses
#35
JOURNAL ARTICLE
Zaid S Salameh, Kenneth N Aycock, Nastaran Alinezhadbalalami, Khan Mohammad Imran, Iain H McKillop, Irving C Allen, Rafael V Davalos
This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TME acidosis, which could provide substantial immunotherapeutic benefits...
November 21, 2023: Annals of Biomedical Engineering
https://read.qxmd.com/read/37971388/one-year-follow-up-results-of-transperineal-biopsy-for-patients-undergoing-irreversible-electroporation-treatment-in-localized-prostate-cancer
#36
JOURNAL ARTICLE
Şükrü Ali Altan, Pınar Güleryüz Kızıl, Nefise Çağla Tarhan, Oztug Adsan
OBJECTIVE: This article reports on the early results of a 1-year follow-up study investigating the efficacy of irreversible electroporation in the treatment of localized prostate cancer. METHODS: The study included 18 out of 40 patients diagnosed with low- and intermediate-risk prostate cancer who underwent irreversible electroporation. Treatment results were evaluated through confirmation biopsies, comparing prostate-specific antigen levels, international prostate symptom scoring, and international index of erectile dysfunction scores before irreversible electroporation and at the 12-month mark...
November 16, 2023: Urol Res Pract
https://read.qxmd.com/read/37962532/development-of-ferroelectric-p-vdf-trfe-microparticles-for-ultrasound-driven-cancer-cell-killing
#37
JOURNAL ARTICLE
Zulmari Silva Pedraza, Yizhan Wang, Corey Carlos, Zhongmin Tang, Jun Li, Weibo Cai, Xudong Wang
Current breast cancer treatments involve aggressive and invasive methods, leaving room for new therapeutic approaches to emerge. In this work, we explore the possibility of using piezoelectric [P(VDF-TrFE)] microparticles (MPs) as a source of inducing irreversible electroporation (IRE) of 4T1 breast cancer cells. We detail the MP formation mechanism and size control and subsequent characterizations of the as-synthesized MPs which confirms the presence of piezoelectric β-phase. Production of the necessary piezoelectric output of the MPs is achieved by ultrasound agitation...
November 14, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/37936668/comprehensive-dose-response-study-of-pulsed-field-ablation-using-a-circular-catheter-compared-with-radiofrequency-ablation-for-pulmonary-vein-isolation-a-preclinical-study
#38
JOURNAL ARTICLE
Jonathan C Hsu, Rajesh S Banker, Douglas N Gibson, Tara Gomez, Dror Berman, Keshava Datta, Qi Chen, Shephal K Doshi
No abstract text is available yet for this article.
October 2023: Heart rhythm O2
https://read.qxmd.com/read/37919538/process-analysis-and-parameter-selection-of-cardiomyocyte-electroporation-based-on-the-finite-element-method
#39
JOURNAL ARTICLE
Hao Zhang, Xingkai Ji, Lianru Zang, Shengjie Yan, Xiaomei Wu
PURPOSE: Pulsed-field ablation (PFA) has attracted attention for the treatment of atrial fibrillation. This study aimed to further explore the relationship between the transmembrane voltage, pore radius and the intensity and duration of pulsed electric fields, which are closely related to the formation of irreversible electroporation. The different mechanisms of microsecond and nanosecond pulses acting on cardiomyocyte cellular and nuclear membranes were studied. METHODS: A 3-D cardiomyocyte model with a nucleus was constructed to simulate the process of electroporation in cells under an electric field...
November 2, 2023: Cardiovascular Engineering and Technology
https://read.qxmd.com/read/37916555/-irreversible-electroporation-in-locally-advanced-pancreatic-cancer
#40
JOURNAL ARTICLE
A N Polyakov, Yu I Patyutko, N E Kudashkin, D M Kantieva, K A Romanova, E A Nasonova, A V Korshak, O A Egenov, D V Podluzhnyi
OBJECTIVE: To determine the feasibility of irreversible electroporation (IRE) for locally advanced pancreatic adenocarcinoma. MATERIAL AND METHODS: Twenty-three patients underwent IRE after chemotherapy for locally advanced pancreatic cancer between 2015 and 2022. IRE was performed during laparotomy as a rule ( n =22). In one case, IRE was combined with palliative pancretoduodenectomy. Nineteen (86.3%) patients received adjuvant chemotherapy after the procedure...
2023: Khirurgiia
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