Wencheng Peng, Yanbing Cao, Yuting Zhang, Aoxue Zhong, Cao Zhang, Zuwu Wei, Xiaolong Liu, Shoulong Dong, Jingcheng Wu, Yanan Xue, Ming Wu, Chenguo Yao
To enhance the efficiency of tumor ablation, we propose the novel pulse configuration nμPEF, which combines both nanosecond and microsecond pulses. This advancement aims to further the potential application of irreversible electroporation (IRE) in oncological therapy. We demonstrated that nμPEF exhibited enhanced efficacy in inducing immunogenic cell death, positioning it as a promising candidate for the next generation of ablative therapy. However, the immune response induced by nμPEF alone was found to be insufficient in effectively suppressing abscopal tumors...
December 7, 2023: Advanced Healthcare Materials