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Irreversible electroporation

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https://www.readbyqxmd.com/read/29679390/clinically-applicable-irreversible-electroporation-for-eradication-of-microorganisms
#1
Maya Korem, Nahum S Goldberg, Amos Cahan, Matan J Cohen, Isaac Nissenbaum, Allon E Moses
Irreversible electroporation (IRE) damages cell membranes and is used in medicine for non-thermal ablation of malignant tumors. Our aim was to evaluate the antimicrobial effect of IRE. The pathogenic microorganisms, S. aureus, S. pyogenes, E. coli, P. aeruginosa and C. albicans were subjected to IRE. Survival was measured as a function of voltage and the number of pulses applied. Combined use of IRE and oxacillin for eradication of S. aureus was also tested. Log10 reduction of microorganisms positively correlated with the number of applied pulses...
April 21, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29678581/molecular-and-histological-study-on-the-effects-of-non-thermal-irreversible-electroporation-on-the-liver
#2
Yanfang Zhang, Chenang Lyu, Yu Liu, Yanpeng Lv, Tammy T Chang, Boris Rubinsky
Non-thermal irreversible electroporation (NTIRE) is a biophysical phenomenon in which certain electric fields delivered across the cell membrane in tissue, cause cell death, without affecting the extracellular matrix. "Minimally invasive regenerative surgery" is a new medical modality for treatment of end-stage organ or tissue failure in which exogenous cells are implanted in a decellularized niche in tissue, formed by the delivery of NTIRE electric fields across a targeted volume of tissue. We anticipate that the success of the procedure will depend on the time of implantation relative to the application of NTIRE...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29628296/reduction-of-muscle-contractions-during-irreversible-electroporation-therapy-using-high-frequency-bursts-of-alternating-polarity-pulses-a-laboratory-investigation-in-an-ex-vivo-swine-model
#3
Michael B Sano, Richard E Fan, Kai Cheng, Yamil Saenz, Geoffrey A Sonn, Gloria L Hwang, Lei Xing
PURPOSE: To compare the intensity of muscle contractions in irreversible electroporation (IRE) treatments when traditional IRE and high-frequency IRE (H-FIRE) waveforms are used in combination with a single applicator and distal grounding pad (A+GP) configuration. MATERIALS AND METHODS: An ex vivo in situ porcine model was used to compare muscle contractions induced by traditional monopolar IRE waveforms vs high-frequency bipolar IRE waveforms. Pulses with voltages between 200 and 5,000 V were investigated, and muscle contractions were recorded by using accelerometers placed on or near the applicators...
April 6, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29621662/plasma-membrane-depolarization-and-permeabilization-due-to-electric-pulses-in-cell-lines-of-different-excitability
#4
Janja Dermol-Černe, Damijan Miklavčič, Matej Reberšek, Primož Mekuč, Sylvia M Bardet, Ryan Burke, Delia Arnaud-Cormos, Philippe Leveque, Rodney O'Connor
In electroporation-based medical treatments, excitable tissues are treated, either intentionally (irreversible electroporation of brain cancer, gene electrotransfer or ablation of the heart muscle, gene electrotransfer of skeletal muscles), or unintentionally (excitable tissues near the target area). We investigated how excitable and non-excitable cells respond to electric pulses, and if electroporation could be an effective treatment of the tumours of the central nervous system. For three non-excitable and one excitable cell line, we determined a strength-duration curve for a single pulse of 10ns-10ms...
March 21, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29595355/irreversible-electroporation-for-the-treatment-of-cardiac-arrhythmias
#5
Alan Sugrue, Elad Maor, Antoni Ivorra, Vaibhav Vaidya, Chance Witt, Suraj Kapa, Samuel Asirvatham
Cardiac ablation is an established treatment modality for the management of patients with cardiac arrhythmias. Current approaches to cardiac ablation employ thermal based energy to achieve lesions (damage) within the heart. There are many shortcomings and limitations of thermal based approaches. Electroporation (DC energy) is a non-thermal alternative approach to ablation has shown significant promise in animal studies. Areas covered: An extensive review of the literature on the application of electroporation for ablation (both cardiac and collateral cardiac tissue) was undertaken...
March 29, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29594551/pair-matched-patient-reported-quality-of-life-and-early-oncological-control-following-focal-irreversible-electroporation-versus-robot-assisted-radical-prostatectomy
#6
Matthijs J Scheltema, John I Chang, Maret Böhm, Willemien van den Bos, Alexandar Blazevski, Ilan Gielchinsky, Anton M F Kalsbeek, Pim J van Leeuwen, Tuan V Nguyen, Theo M de Reijke, Amila R Siriwardana, James E Thompson, Jean J de la Rosette, Phillip D Stricker
PURPOSE: The design, conduct and completion of randomized trials for curative prostate cancer (PCa) treatments are challenging. To evaluate the effect of robot-assisted radical prostatectomy (RARP) versus focal irreversible electroporation (IRE) on patient-reported quality of life (QoL) and early oncological control using propensity-scored matching. METHODS: Patients with T1c-cT2b significant PCa (high-volume ISUP 1 or any 2/3) who received unifocal IRE were pair-matched to patients who received nerve-sparing RARP...
March 28, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29560492/the-role-of-protein-loss-and-denaturation-in-determining-outcomes-of-heat-cryotherapy-and-irreversible-electroporation-on-cardiomyocytes
#7
Feng Liu, Priyatanu Roy, Qi Shao, Chunlan Jiang, Jeunghwan Choi, Connie Chung, Dushyant Mehra, Dr John Bischof
Atrial fibrillation affects millions of people in the US. Focal therapy is an attractive treatment for atrial fibrillation that avoids the debilitating effects of drugs for disease control. Perhaps the most widely used focal therapy for atrial fibrillation (AF) is heat-based radiofrequency (heating), although cryotherapy (cryo) is rapidly replacing it due to a reduction in side effects and positive clinical outcomes. A third focal therapy, irreversible electroporation (IRE), is also being considered. This study was designed to help guide treatment thresholds and compare mechanism of action across heating, cryo, and IRE...
February 17, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29558871/effect-of-electrode-distance-in-grid-electrode-numerical-models-and-in-vitro-tests
#8
Alessia Ongaro, Luca Giovanni Campana, Monica De Mattei, Paolo Di Barba, Fabrizio Dughiero, Michele Forzan, Maria Evelina Mognaschi, Agnese Pellati, Carlo Riccardo Rossi, Clara Bernardello, Elisabetta Sieni
Electrochemotherapy is an emerging local treatment for the management of superficial tumors and, among these, also chest wall recurrences from breast cancer. Generally, the treatment of this peculiar type of tumor requires the coverage of large skin areas. In these cases, electrochemotherapy treatment by means of standard small size needle electrodes (an array of 0.73 cm spaced needles, which covers an area of 1.5 cm2 ) is time-consuming and can allow an inhomogeneous coverage of the target area. We have previously designed grid devices suitable for treating an area ranging from 12 to 200 cm2 ...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29552341/irreversible-electroporation-of-locally-advanced-solid-pseudopapillary-carcinoma-of-the-pancreas-a-case-report
#9
Luciano Tarantino, Aurelio Nasto, Giuseppina Busto, Vincenzo Iovino, Raffaele Fristachi, Sara Bortone
Introduction: Solid pseudopapillary Carcinoma (SPC) is a rare pancreatic Tumor with variable, usually low, malignancy potential. Howewer, several SPC are associated with aggressive behavior, local vascular infiltration, organ invasion, distant metastasis, and can be unresectable. Irreversible Electroporation (IRE) is an emerging non-thermal ablation technique for the treatment of locally advanced pancreatic carcinoma. We report the results of four year disease-free follow-up in a case of locally advanced unresectable SPC treated with IRE...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29525118/fellows-perspective-of-hpb-training-programs-in-north-america-results-of-a-survey
#10
Imran A Siddiqui, Amit V Sastry, John B Martinie, Dionisios Vrochides, Erin H Baker, David A Iannitti
BACKGROUND: Sixteen hepatopancreatobiliary fellowship programs in North America are accredited by the Fellowship Council. This study aims to assess fellows' perceptions of their training program. METHODS: A multiple-choice questionnaire was sent to 35 fellows to assess how they perceived their training: academics, research, operative experiences, autonomy, mentorship, program quality and weaknesses. The survey was developed using the SurveyMonkey® tool. RESULTS: Twenty-four of 35 fellows completed the survey...
March 7, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29511429/high-voltage-pulsed-electric-field-plus-photodynamic-therapy-kills-breast-cancer-cells-by-triggering-apoptosis
#11
Haixia Zhang, Kuangpeng Liu, Zhixiao Xue, Huijuan Yin, Huajiang Dong, Wendong Jin, Xiafei Shi, Han Wang, Hai Wang
This study evaluated the effects and mechanism of action of combining irreversible electroporation (IRE) and photodynamic therapy (PDT) in breast cancer cells in vitro and in vivo . Jin's formula was used to assess killing efficacy of different IRE+PDT dosing combinations in breast cancer MCF-7 cells. Flow cytometry, high-content imaging, and confocal laser scanning microscopy were used to detect apoptosis. qRT-PCR and western blotting were used to evaluate expression of apoptosis-related genes and proteins...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29506753/the-use-of-ire-in-multi-modality-treatment-for-oligometastatic-pancreatic-cancer
#12
Young Hong, Jonathan Rice, Divyansh Sharma, Robert C G Martin
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) often presents late with only 20% of patients being candidates for resection while majority already have advanced metastases with median overall survival of 3-6 months. Currently, the role of oligometastasectomy and local therapy options in PDAC is unknown in patients who have favorable response to systemic chemotherapy. The aim of this study is to analyze the survival outcome of oligometastasectomy and local IRE therapy in select patients who are treated with systemic chemotherapy for PDAC metastases...
March 2, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29486332/optimization-of-a-single-insertion-electrode-array-for-the-creation-of-clinically-relevant-ablations-using-high-frequency-irreversible-electroporation
#13
Michael B Sano, Matthew R DeWitt, Stephanie D Teeter, Lei Xing
High-frequency irreversible electroporation (H-FIRE) is an emerging ablation modality, delivering rapid bursts of bipolar microsecond-duration electrical pulses to non-thermally ablate tissue including tumors. With advantages over current electroporation techniques including mitigation of muscle stimulation and reduced susceptibility to heterogeneous tissue properties, H-FIRE may produce more uniform and predictable ablations and can potentially be delivered with a single applicator device. However, the resulting ablations tend to be smaller than those provided with equivalent energy monopolar pulse protocols...
February 17, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29482386/antitumor-efficacy-of-liposome-encapsulated-nvp-bez-235-in-combination-with-irreversible-electroporation
#14
Li Tian, Yang Qiao, Patrick Lee, Lucas Wang, Ashley Chang, Saisree Ravi, Thomas A Rogers, Linfeng Lu, Burapol Singhana, Jun Zhao, Marites P Melancon
Irreversible electroporation (IRE) is an emerging minimally invasive tumor ablation technique that delivers short pulses of strong electric fields and kills cancer cells by disrupting their cell membranes with the electric pulses. However, clinical studies report that more than 10% of local tumor recurrences occur at the original ablated site. NVP BEZ-235 (BEZ) is a dual PI3K/mTOR inhibitor that has substantial anticancer effects. However, the clinical trials of BEZ was not satisfactory because of its low bioavailability and high toxicity, which stemmed from the use of oral administration of high doses over a long period of time...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29464927/microbial-lipid-extraction-from-lipomyces-starkeyi-using-irreversible-electroporation
#15
Ahasanul Karim, Abu Yousuf, M Amirul Islam, Yasir H Naif, Che Ku Mohammad Faizal, Md Zahangir Alam, Domenico Pirozzi
The aim of the study was to investigate the feasibility of using irreversible electroporation (EP) as a microbial cell disruption technique to extract intracellular lipid within short time and in an eco-friendly manner. An EP circuit was designed and fabricated to obtain 4 kV with frequency of 100 Hz of square waves. The yeast cells of Lipomyces starkeyi (L. starkeyi) were treated by EP for 2-10 min where the distance between electrodes was maintained at 2, 4 and 6 cm. Colony forming units (CFU) were counted to observe the cell viability under the high voltage electric field...
February 21, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29458955/percutaneous-liver-tumour-ablation-image-guidance-endpoint-assessment-and-quality-control
#16
REVIEW
Robbert S Puijk, Alette H Ruarus, Hester J Scheffer, Laurien G P H Vroomen, Aukje A J M van Tilborg, Jan J J de Vries, Ferco H Berger, Petrousjka M P van den Tol, Martijn R Meijerink
Liver tumour ablation nowadays represents a routine treatment option for patients with primary and secondary liver tumours. Radiofrequency ablation and microwave ablation are the most widely adopted methods, although novel techniques, such as irreversible electroporation, are quickly working their way up. The percutaneous approach is rapidly gaining popularity because of its minimally invasive character, low complication rate, good efficacy rate, and repeatability. However, matched to partial hepatectomy and open ablations, the issue of ablation site recurrences remains unresolved and necessitates further improvement...
February 2018: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/29458954/irreversible-electroporation-in-hepatopancreaticobiliary-tumours
#17
REVIEW
A H Ruarus, L G P H Vroomen, R S Puijk, H J Scheffer, B M Zonderhuis, G Kazemier, M P van den Tol, F H Berger, M R Meijerink
Hepatopancreaticobiliary tumours are often diagnosed at an advanced disease stage, in which encasement or invasion of local biliary or vascular structures has already occurred. Irreversible electroporation (IRE) is an image-guided tumour ablation technique that induces cell death by exposing the tumour to high-voltage electrical pulses. The cellular membrane is disrupted, while sparing the extracellular matrix of critical tubular structures. The preservation of tissue integrity makes IRE an attractive treatment option for tumours in the vicinity of vital structures such as splanchnic blood vessels and major bile ducts...
February 2018: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/29399927/irreversible-electroporation-ablation-for-atrial-fibrillation
#18
Adam Wojtaszczyk, Guido Caluori, Martin Pešl, Katarina Melajova, Zdeněk Stárek
Atrial fibrillation (AF) is one of the most important problems in modern cardiology. Thermal ablation therapies, especially radiofrequency ablation (RF), are currently "gold standard" to treat symptomatic AF by localized tissue necrosis. Despite the improvements in reestablishing sinus rhythm using available methods, both success rate and safety are limited by the thermal nature of procedures. Thus, while keeping the technique in clinical practice, safer and more versatile methods of removing abnormal tissue are being investigated...
February 5, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29396626/-ablative-therapy-of-small-renal-masses
#19
REVIEW
M C Kriegmair, N Wagener, S J Diehl, N Rathmann
Renal cell cancer is nowadays predominantly diagnosed in early stages due to the widespread use of sectional imaging for unrelated symptoms. Small renal masses (<4 cm) feature a largely indolent biology with a very low risk for metastasis or even a benign biology in up to 30% of the cases. Consequently, there is a need for less invasive therapeutic alternatives to nephron-sparing surgery. Meanwhile, there is a broad portfolio of local ablation techniques to treat small renal tumors. These include the extensively studied radiofrequency ablation and cryoablation techniques as well as newer modalities like microwave ablation and irreversible electroporation as more experimental techniques...
February 2, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29358001/catheter-based-endobronchial-electroporation-is-feasible-for-the-focal-treatment-of-peribronchial-tumors
#20
Hiroshi Kodama, Laurien G Vroomen, Eisuke Ueshima, Jennifer Reilly, Whitney Brandt, Lee-Ronn Paluch, Sebastien Monette, David Jones, Stephen B Solomon, Govindarajan Srimathveeravalli
OBJECTIVE: To evaluate the feasibility of catheter-based endobronchial electroporation for the treatment of peribronchial tumors and assess the incidence of treatment-related adverse events. METHODS: Cytotoxicity of electroporation with or without cisplatin or gefitinib was assessed in vitro with lung cancer and normal cell lines. A novel catheter was designed for endobronchial electroporation, and computer simulations were used to predict in vivo treatment effects...
May 2018: Journal of Thoracic and Cardiovascular Surgery
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