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Irreversible electroporation

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https://www.readbyqxmd.com/read/29878378/the-efficacy-of-combination-of-induction-chemotherapy-and-irreversible-electroporation-ablation-for-patients-with-locally-advanced-pancreatic-adenocarcinoma
#1
Kai-Wen Huang, Po-Chih Yang, Uei Pua, Man-Deuk Kim, Sheng-Ping Li, Yu-Dong Qiu, Tian-Qiang Song, Po-Chin Liang
BACKGROUND AND OBJECTIVES: Irreversible electroporation (IRE) is a non-thermal focal therapy that utilizes high voltage electric pulses to permanently rupture the cellular membrane and induce cell death. In this multi-center study, we evaluated the safety and efficacy of IRE in patients with locally advanced pancreatic cancer (LAPC). METHODS: From 2012 to 2015, we performed laparotomic and laparoscopic IRE in a total of 70 patients with stage III LAPC. Either gemcitabine-based or TS-1 (Tegafur, Gimeracil, and Oteracil) chemotherapy was applied for at least 3 months before the IRE...
June 7, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29808697/-a-development-and-overview-of-the-use-of-chemotherapy-and-the-role-of-radiotherapy-and-surgery-in-patients-with-newly-diagnosed-pancreatic-tumor-and-cancer-in-the-current-5-year-center-practice
#2
S Vokurka, M Votavová, J Kulhánková, H Korunková, O Fiala, K Štěrbová, T Svoboda, R Vojtíšek, V M Matějka, J Fínek
BACKGROUND: Chemotherapy (CHT), surgery and radiotherapy (RT) are essential modalities in the treatment of pancreatic malignancies. Their use in practice may be influenced by a number of factors. PATIENTS AND METHODS: Retrospective analysis of CHT, surgery and RT indications and CHT results in patients reported with pancreatic tumor in Pilsen in 2012-2016. RESULTS: A total of 348 patients with median age 68 (19-89) years with newly diagnosed pancreatic tumor, resp...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29806513/effects-of-internal-electrode-cooling-on-irreversible-electroporation-using-a-perfused-organ-model
#3
Timothy J O'Brien, Mohammad Bonakdar, Suyashree Bhonsle, Robert E Neal, Charles H Aardema, John L Robertson, S Nahum Goldberg, Rafael V Davalos
PURPOSE: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused porcine liver model. MATERIALS AND METHODS: A bipolar electrode delivered IRE electric pulses with or without activation of internal cooling to nine porcine mechanically perfused livers. Pulse schemes included a constant voltage, and a preconditioned delivery combined with an arc-mitigation algorithm...
May 28, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29796702/-small-renal-cell-carcinoma-active-surveillance-and-ablation
#4
J J Wendler, R Damm, U-B Liehr, T Brunner, M Pech, M Schostak
The incidence of renal cell carcinoma has been rising for years. At the same time there is an increasing prevalence of chronic renal failure with subsequent higher morbidity and shorter life expectancy in those affected. In the last decades the gold standard has thus shifted from radical to partial nephrectomy or tumor enucleation. A treatment alternative can be advantageous for selected patients with high morbidity and an increased risk of complications in anesthesia or surgery. Active surveillance represents a controlled delay in the initiation of treatment with a curative intention...
May 23, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29755766/percutaneous-irreversible-electroporation-with-systemic-treatment-for-locally-advanced-pancreatic-adenocarcinoma
#5
Edward Leen, John Picard, Justin Stebbing, Mark Abel, Tony Dhillon, Harpreet Wasan
Background: The prognosis for unresectable locally advanced pancreatic adenocarcinoma (LAPC) remains poor. There is increasing interest in modern ablative techniques to improve outcomes. We report on the potential value of integrating percutaneous irreversible electroporation (IRE) in patients undergoing systemic chemotherapy. Methods: Seventy-five patients with unresectable pancreatic carcinoma underwent percutaneous IRE after chemotherapy using computerised tomography guidance under general anaesthesia...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29743538/which-technology-to-select-for-primary-focal-treatment-of-prostate-cancer-european-section-of-urotechnology-esut-position-statement
#6
REVIEW
Roman Ganzer, Vinodh Kumar Adithyaa Arthanareeswaran, Hashim U Ahmed, Andrea Cestari, Pascal Rischmann, Georg Salomon, Dogu Teber, Evangelos Liatsikos, Jens-Uwe Stolzenburg, Eric Barret
BACKGROUND: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics...
May 9, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29695251/efficacy-and-mechanism-of-steep-pulse-irreversible-electroporation-technology-on-xenograft-model-of-nude-mice-a-preclinical-study
#7
Zuoqing Song, Xiaohong Xu, Minghui Liu, Jinghao Liu, Jun Chen, Chengxiang Li, Chenguo Yao, Qinghua Zhou
BACKGROUND: Steep pulse therapy can irreversible electrically brackdown of tumor membrance and cause cell death. In previous studies, we investigated the effect of steep pulsed electroporation on the killing of large cell lung cancer cell line L981- in vitro, and determined the best parameters for killing lung cancer cells by steep pulse technology. But the optimal parameters and the mechanisms of steep pulse irreversible electroporation technology on nude mouse tumor model are unclear...
April 25, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29694357/development-of-a-statistical-model-for-cervical-cancer-cell-death-with-irreversible-electroporation-in-vitro
#8
Yongji Yang, Michael A J Moser, Edwin Zhang, Wenjun Zhang, Bing Zhang
PURPOSE: The aim of this study was to develop a statistical model for cell death by irreversible electroporation (IRE) and to show that the statistic model is more accurate than the electric field threshold model in the literature using cervical cancer cells in vitro. METHODS: HeLa cell line was cultured and treated with different IRE protocols in order to obtain data for modeling the statistical relationship between the cell death and pulse-setting parameters. In total, 340 in vitro experiments were performed with a commercial IRE pulse system, including a pulse generator and an electric cuvette...
2018: PloS One
https://www.readbyqxmd.com/read/29687261/conductivity-rise-during-irreversible-electroporation-true-permeabilization-or-heat
#9
Alette H Ruarus, Laurien G P H Vroomen, Robbert S Puijk, Hester J Scheffer, Theo J C Faes, Martijn R Meijerink
PURPOSE: Irreversible electroporation (IRE) induces apoptosis with high-voltage electric pulses. Although the working mechanism is non-thermal, development of secondary Joule heating occurs. This study investigated whether the observed conductivity rise during IRE is caused by increased cellular permeabilization or heat development. METHODS: IRE was performed in a gelatin tissue phantom, in potato tubers, and in 30 patients with unresectable colorectal liver metastases (CRLM)...
April 23, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29679390/clinically-applicable-irreversible-electroporation-for-eradication-of-micro-organisms
#10
M Korem, N S Goldberg, A Cahan, M J Cohen, I Nissenbaum, A E Moses
Irreversible electroporation (IRE) damages cell membranes and is used in medicine for nonthermal ablation of malignant tumours. Our aim was to evaluate the antimicrobial effect of IRE. The pathogenic micro-organisms, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and Candida albicans were subjected to IRE. Survival was measured as a function of voltage and the number of pulses applied. Combined use of IRE and oxacillin for eradication of Staph. aureus was also tested...
July 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29678581/molecular-and-histological-study-on-the-effects-of-non-thermal-irreversible-electroporation-on-the-liver
#11
Yanfang Zhang, Chenang Lyu, Yu Liu, Yanpeng Lv, Tammy T Chang, Boris Rubinsky
Non-thermal irreversible electroporation (NTIRE) is a biophysical phenomenon in which certain electric fields delivered across the cell membrane in tissue, cause cell death, without affecting the extracellular matrix. "Minimally invasive regenerative surgery" is a new medical modality for treatment of end-stage organ or tissue failure in which exogenous cells are implanted in a decellularized niche in tissue, formed by the delivery of NTIRE electric fields across a targeted volume of tissue. We anticipate that the success of the procedure will depend on the time of implantation relative to the application of NTIRE...
June 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29628296/reduction-of-muscle-contractions-during-irreversible-electroporation-therapy-using-high-frequency-bursts-of-alternating-polarity-pulses-a-laboratory-investigation-in-an-ex-vivo-swine-model
#12
Michael B Sano, Richard E Fan, Kai Cheng, Yamil Saenz, Geoffrey A Sonn, Gloria L Hwang, Lei Xing
PURPOSE: To compare the intensity of muscle contractions in irreversible electroporation (IRE) treatments when traditional IRE and high-frequency IRE (H-FIRE) waveforms are used in combination with a single applicator and distal grounding pad (A+GP) configuration. MATERIALS AND METHODS: An ex vivo in situ porcine model was used to compare muscle contractions induced by traditional monopolar IRE waveforms vs high-frequency bipolar IRE waveforms. Pulses with voltages between 200 and 5,000 V were investigated, and muscle contractions were recorded by using accelerometers placed on or near the applicators...
June 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29621662/plasma-membrane-depolarization-and-permeabilization-due-to-electric-pulses-in-cell-lines-of-different-excitability
#13
Janja Dermol-Černe, Damijan Miklavčič, Matej Reberšek, Primož Mekuč, Sylvia M Bardet, Ryan Burke, Delia Arnaud-Cormos, Philippe Leveque, Rodney O'Connor
In electroporation-based medical treatments, excitable tissues are treated, either intentionally (irreversible electroporation of brain cancer, gene electrotransfer or ablation of the heart muscle, gene electrotransfer of skeletal muscles), or unintentionally (excitable tissues near the target area). We investigated how excitable and non-excitable cells respond to electric pulses, and if electroporation could be an effective treatment of the tumours of the central nervous system. For three non-excitable and one excitable cell line, we determined a strength-duration curve for a single pulse of 10ns-10ms...
August 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29595355/irreversible-electroporation-for-the-treatment-of-cardiac-arrhythmias
#14
Alan Sugrue, Elad Maor, Antoni Ivorra, Vaibhav Vaidya, Chance Witt, Suraj Kapa, Samuel Asirvatham
Cardiac ablation is an established treatment modality for the management of patients with cardiac arrhythmias. Current approaches to cardiac ablation employ thermal based energy to achieve lesions (damage) within the heart. There are many shortcomings and limitations of thermal based approaches. Electroporation (DC energy) is a non-thermal alternative approach to ablation that has shown significant promise in animal studies. Areas covered: An extensive review of the literature on the application of electroporation for ablation (both cardiac and collateral cardiac tissue) was undertaken...
May 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29594551/pair-matched-patient-reported-quality-of-life-and-early-oncological-control-following-focal-irreversible-electroporation-versus-robot-assisted-radical-prostatectomy
#15
Matthijs J Scheltema, John I Chang, Maret Böhm, Willemien van den Bos, Alexandar Blazevski, Ilan Gielchinsky, Anton M F Kalsbeek, Pim J van Leeuwen, Tuan V Nguyen, Theo M de Reijke, Amila R Siriwardana, James E Thompson, Jean J de la Rosette, Phillip D Stricker
PURPOSE: The design, conduct and completion of randomized trials for curative prostate cancer (PCa) treatments are challenging. To evaluate the effect of robot-assisted radical prostatectomy (RARP) versus focal irreversible electroporation (IRE) on patient-reported quality of life (QoL) and early oncological control using propensity-scored matching. METHODS: Patients with T1c-cT2b significant PCa (high-volume ISUP 1 or any 2/3) who received unifocal IRE were pair-matched to patients who received nerve-sparing RARP...
March 28, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29560492/the-role-of-protein-loss-and-denaturation-in-determining-outcomes-of-heat-cryotherapy-and-irreversible-electroporation-on-cardiomyocytes
#16
Feng Liu, Priyatanu Roy, Qi Shao, Chunlan Jiang, Jeunghwan Choi, Connie Chung, Dushyant Mehra, Dr John Bischof
Atrial fibrillation affects millions of people in the US. Focal therapy is an attractive treatment for atrial fibrillation that avoids the debilitating effects of drugs for disease control. Perhaps the most widely used focal therapy for atrial fibrillation (AF) is heat-based radiofrequency (heating), although cryotherapy (cryo) is rapidly replacing it due to a reduction in side effects and positive clinical outcomes. A third focal therapy, irreversible electroporation (IRE), is also being considered. This study was designed to help guide treatment thresholds and compare mechanism of action across heating, cryo, and IRE...
February 17, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29558871/effect-of-electrode-distance-in-grid-electrode-numerical-models-and-in-vitro-tests
#17
Alessia Ongaro, Luca Giovanni Campana, Monica De Mattei, Paolo Di Barba, Fabrizio Dughiero, Michele Forzan, Maria Evelina Mognaschi, Agnese Pellati, Carlo Riccardo Rossi, Clara Bernardello, Elisabetta Sieni
Electrochemotherapy is an emerging local treatment for the management of superficial tumors and, among these, also chest wall recurrences from breast cancer. Generally, the treatment of this peculiar type of tumor requires the coverage of large skin areas. In these cases, electrochemotherapy treatment by means of standard small size needle electrodes (an array of 0.73 cm spaced needles, which covers an area of 1.5 cm2 ) is time-consuming and can allow an inhomogeneous coverage of the target area. We have previously designed grid devices suitable for treating an area ranging from 12 to 200 cm2 ...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29552341/irreversible-electroporation-of-locally-advanced-solid-pseudopapillary-carcinoma-of-the-pancreas-a-case-report
#18
Luciano Tarantino, Aurelio Nasto, Giuseppina Busto, Vincenzo Iovino, Raffaele Fristachi, Sara Bortone
Introduction: Solid pseudopapillary Carcinoma (SPC) is a rare pancreatic Tumor with variable, usually low, malignancy potential. Howewer, several SPC are associated with aggressive behavior, local vascular infiltration, organ invasion, distant metastasis, and can be unresectable. Irreversible Electroporation (IRE) is an emerging non-thermal ablation technique for the treatment of locally advanced pancreatic carcinoma. We report the results of four year disease-free follow-up in a case of locally advanced unresectable SPC treated with IRE...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29525118/fellows-perspective-of-hpb-training-programs-in-north-america-results-of-a-survey
#19
Imran A Siddiqui, Amit V Sastry, John B Martinie, Dionisios Vrochides, Erin H Baker, David A Iannitti
BACKGROUND: Sixteen hepatopancreatobiliary fellowship programs in North America are accredited by the Fellowship Council. This study aims to assess fellows' perceptions of their training program. METHODS: A multiple-choice questionnaire was sent to 35 fellows to assess how they perceived their training: academics, research, operative experiences, autonomy, mentorship, program quality and weaknesses. The survey was developed using the SurveyMonkey® tool. RESULTS: Twenty-four of 35 fellows completed the survey...
March 7, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29511429/high-voltage-pulsed-electric-field-plus-photodynamic-therapy-kills-breast-cancer-cells-by-triggering-apoptosis
#20
Haixia Zhang, Kuangpeng Liu, Zhixiao Xue, Huijuan Yin, Huajiang Dong, Wendong Jin, Xiafei Shi, Han Wang, Hai Wang
This study evaluated the effects and mechanism of action of combining irreversible electroporation (IRE) and photodynamic therapy (PDT) in breast cancer cells in vitro and in vivo . Jin's formula was used to assess killing efficacy of different IRE+PDT dosing combinations in breast cancer MCF-7 cells. Flow cytometry, high-content imaging, and confocal laser scanning microscopy were used to detect apoptosis. qRT-PCR and western blotting were used to evaluate expression of apoptosis-related genes and proteins...
2018: American Journal of Translational Research
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