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Irreversible electroporation

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https://www.readbyqxmd.com/read/27907057/the-effects-of-irreversible-electroporation-on-the-colon-in-a-porcine-model
#1
Xiaomei Luo, Xianjun Liang, Jiannan Li, Jian Shi, Wenlong Zhang, Wei Chai, Jiuping Wu, Shuai Guo, Gang Fang, Xulong Zhou, Jianhua Zhang, Kecheng Xu, Jianying Zeng, Lizhi Niu
BACKGROUND AND AIM: Irreversible electroporation (IRE) is a method of targeted cell ablation which has been suggested as a potential cancer therapy as it leaves structures such as blood vessels and the extracellular matrix intact, thereby allowing the rapid recovery of healthy tissue. Here, we investigated the effects of IRE on the colon in vivo in a porcine model. METHODS: IRE ablation was performed on the colon walls of 12 female Tibet mini-pigs, creating a total of 24 lesions...
2016: PloS One
https://www.readbyqxmd.com/read/27893744/optimization-of-irreversible-electroporation-protocols-for-in-vivo-myocardial-decellularization
#2
Yaniv Zager, David Kain, Natalie Landa, Jonathan Leor, Elad Maor
BACKGROUND: Irreversible electroporation (IRE) is a non-thermal cell ablation approach that induces selective damage to cell membranes only. The purpose of the current study was to evaluate and optimize its use for in-vivo myocardial decellularization. METHODS: Forty-two Sprague-Dawley rats were used to compare myocardial damage of seven different IRE protocols with anterior myocardial infarction damage. An in-vivo open thoracotomy model was used, with two-needle electrodes in the anterior ventricular wall...
2016: PloS One
https://www.readbyqxmd.com/read/27870918/time-dependent-impact-of-irreversible-electroporation-on-pancreas-liver-blood-vessels-and-nerves-a-systematic-review-of-experimental-studies
#3
J A Vogel, E van Veldhuisen, P Agnass, J Crezee, F Dijk, J Verheij, T M van Gulik, M R Meijerink, L G Vroomen, K P van Lienden, M G Besselink
INTRODUCTION: Irreversible electroporation (IRE) is a novel ablation technique in the treatment of unresectable cancer. The non-thermal mechanism is thought to cause mostly apoptosis compared to necrosis in thermal techniques. Both in experimental and clinical studies, a waiting time between ablation and tissue or imaging analysis to allow for cell death through apoptosis, is often reported. However, the dynamics of the IRE effect over time remain unknown. Therefore, this study aims to summarize these effects in relation to the time between treatment and evaluation...
2016: PloS One
https://www.readbyqxmd.com/read/27856215/irreversible-electroporation-for-locally-advanced-pancreatic-cancer
#4
J-P Tasu, G Vesselle, G Herpe, J-P Richer, S Boucecbi, S Vélasco, M Carretier, B Debeane, D Tougeron
Pancreatic adenocarcinoma is one of the solid cancers associated with the poorest prognosis; the only curative treatment remains surgical resection but in most cases, this treatment is not possible because of distant metastasis or local extension. Irreversible electroporation is a new tumor ablation technique, which provides cellular apoptosis without any thermal coagulation effect. This technique helps preserve the ducts, vessels or nerves located in the treatment area. This article reviews the current knowledge regarding the use of electroporation for the treatment of pancreatic adenocarcinoma...
December 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27851950/modeling-of-transmembrane-potential-in-realistic-multicellular-structures-before-electroporation
#5
Tomo Murovec, Daniel C Sweeney, Eduardo Latouche, Rafael V Davalos, Christian Brosseau
Many approaches for studying the transmembrane potential (TMP) induced during the treatment of biological cells with pulsed electric fields have been reported. From the simple analytical models to more complex numerical models requiring significant computational resources, a gamut of methods have been used to recapitulate multicellular environments in silico. Cells have been modeled as simple shapes in two dimensions as well as more complex geometries attempting to replicate realistic cell shapes. In this study, we describe a method for extracting realistic cell morphologies from fluorescence microscopy images to generate the piecewise continuous mesh used to develop a finite element model in two dimensions...
November 15, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27837054/the-safety-and-efficacy-of-irreversible-electroporation-for-large-hepatocellular-carcinoma
#6
Jianying Zeng, Guifeng Liu, Zhong-Hai Li, Yi Yang, Gang Fang, Rong-Rong Li, Ke-Cheng Xu, Lizhi Niu
This study aimed to investigate the safety and effectiveness of irreversible electroporation ablation for unresectable large liver cancer. Fourteen patients were enrolled: 8 with large hepatocellular carcinoma (tumor diameter: 5.1-11.5 cm) and 6 with medium hepatocellular carcinoma (tumor diameter: 3.0-4.1 cm). All patients received percutaneous irreversible electroporation ablation. Ablation time and the incidence of complications were assessed by a t test. Post-irreversible electroporation and regular contrast-enhanced computerized tomography scans were performed to investigate the effect of tumor size (large vs medium) on irreversible electroporation treatment efficacy; 4-table data were assessed using a Fisher exact test...
November 11, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27795815/arterial-complication-of-irreversible-electroporation-procedure-for-locally-advanced-pancreatic-cancer
#7
Yahya Ekici, Tugan Tezcaner, Hüseyin Onur Aydın, Fatih Boyvat, Gökhan Moray
Irreversible electroporation (IRE) is a non-thermal ablation technique used especially in locally advanced pancreatic carcinomas that are considered surgically unresectable. We present the first case of acute superior mesenteric artery (SMA) occlusion secondary to pancreatic IRE procedure that has not been reported before in the literature. A 66-year-old man underwent neoadjuvant chemoradiotherapy for locally advanced pancreatic ductal adenocarcinoma. IRE procedure was applied to the patient during laparotomy under general anesthesia...
October 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27762603/update-on-image-guided-percutaneous-ablation-of-breast-cancer
#8
Margaret M Fleming, Anna I Holbrook, Mary S Newell
OBJECTIVE: The purpose of this article is to delineate the potential techniques for percutaneous ablation of breast cancer, discuss the advantages and disadvantages of each technique, and provide results from recent studies on these technologies. The techniques discussed are cryotherapy, laser irradiation, microwave irradiation, radiofrequency ablation, high-intensity focused ultrasound ablation, and irreversible electroporation. CONCLUSION: Although percutaneous ablation techniques have some promising potential for less-invasive treatment of breast cancer, larger multicenter trials are needed to confirm their efficacy, especially in comparison with the reference standard of lumpectomy...
October 20, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27758723/-new-developments-in-the-treatment-of-pancreatic-cancer
#9
H A Marsman, M G Besselink
- The incidence of pancreatic cancer is increasing due to the ageing population among other things, while 5-year survival has improved in the past two decades from 3 to 7%.- In case of biliary obstruction due to pancreatic cancer, biliary drainage before surgery or ablative therapy using a covered metal stent instead of plastic reduces the rate of complications.- In patients with metastasized pancreatic cancer a combination of folinic acid, fluorouracil, irinotecan and oxaliplatin (FOLFIRINOX) results in improved survival...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27727027/intra-operative-navigation-of-a-3-dimensional-needle-localization-system-for-precision-of-irreversible-electroporation-needles-in-locally-advanced-pancreatic-cancer
#10
L Bond, B Schulz, T VanMeter, R C G Martin
INTRODUCTION: Irreversible electroporation (IRE) uses multiple needles and a series of electrical pulses to create pores in cell membranes and cause cell apoptosis. One of the demands of IRE is the precise needle spacing required. Two-dimensional intraoperative ultrasound (2-D iUS) is currently used to measure inter-needle distances but requires significant expertise. This study evaluates the potential of three-dimensional (3-D) image guidance for placing IRE needles and calculating needle spacing...
September 29, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27712669/intraoperative-adverse-events-during-irreversible-electroporation-a-call-for-caution
#11
Patryk Kambakamba, John M Bonvini, Michael Glenck, Liliana Castrezana López, Thomas Pfammatter, Pierre-Alain Clavien, Michelle L DeOliveira
BACKGROUND: Irreversible electroporation is increasingly used for treatment of solid tumors, but safety data remain scarce. This study aimed to describe intraoperative adverse events associated with irreversible electroporation in patients undergoing solid tumor ablation. METHODS: We analyzed demographic and intraoperative data for patients (n = 43) undergoing irreversible electroporation for hepato-pancreato-biliary and retroperitoneal malignancies (2012 to 2015)...
October 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27697580/nanoknife-electroporation-ablation-trial-a-prospective-development-study-investigating-focal-irreversible-electroporation-for-localized-prostate-cancer
#12
Massimo Valerio, Louise Dickinson, Afia Ali, Navin Ramachadran, Ian Donaldson, Neil Mccartan, Alex Freeman, Hashim U Ahmed, Mark Emberton
PURPOSE: Irreversible electroporation has attractive attributes for focal ablation, namely nonthermal effect, precise demarcation of treatment and tissue selectivity. We report a prospective development study investigating focal irreversible electroporation. MATERIALS AND METHODS: A total of 20 men with certain characteristics were recruited for study, including a visible index lesion on anterior magnetic resonance imaging that was concordant with transperineal targeted and template prostate mapping biopsy, absent clinically significant disease noted elsewhere (University College London definition 2) and prostate specific antigen 15 ng/ml or less...
September 30, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27693939/irreversible-electroporation-inhibits-pro-cancer-inflammatory-signaling-in-triple-negative-breast-cancer-cells
#13
Ishan Goswami, Sheryl Coutermarsh-Ott, Ryan G Morrison, Irving C Allen, Rafael V Davalos, Scott S Verbridge, Lissett R Bickford
Low-level electric fields have been demonstrated to induce spatial re-distribution of cell membrane receptors when applied for minutes or hours. However, there is limited literature on the influence on cell signaling with short transient high-amplitude pulses typically used in irreversible electroporation (IRE) for cancer treatment. Moreover, literature on signaling pertaining to immune cell trafficking after IRE is conflicting. We hypothesized that pulse parameters (field strength and exposure time) influence cell signaling and subsequently impact immune-cell trafficking...
February 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/27674060/outcomes-associated-with-a-combination-of-radiation-therapy-and-irreversible-electroporation-for-pancreatic-cancer
#14
S Gajjar, R Yechieli, A H Wolfson, G Narayanan, J Merchan, L Portelance
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27670618/an-update-on-focal-therapy-for-prostate-cancer
#15
REVIEW
Marlon Perera, Nishanth Krishnananthan, Uri Lindner, Nathan Lawrentschuk
Globally, the increased uptake of serum PSA level screening led to an increase in the number of diagnoses of low-risk and intermediate-risk prostate cancer. Traditionally, these patients have been considered for either active surveillance programmes or radical whole-gland therapies, such as prostatectomy or radiotherapy. Focal therapy is an emerging treatment option that involves the focal ablation of prostate cancer with preservation of surrounding healthy tissue. This approach might result in reduced morbidity when compared with whole-gland therapies...
November 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27670543/feasibility-and-safety-of-irreversible-electroporation-in-locally-advanced-pelvic-and-retroperitoneal-tumors
#16
Casey E Underhill, Nathaniel J Walsh, Brian P Bateson, Caleb Mentzer, Edward J Kruse
No abstract text is available yet for this article.
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27663353/characterization-of-irreversible-electroporation-ablation-with-a-validated-perfused-organ-model
#17
Suyashree Bhonsle, Mohammad Bonakdar, Robert E Neal, Charles Aardema, John L Robertson, Jonathon Howarth, Helen Kavnoudias, Kenneth R Thomson, S Nahum Goldberg, Rafael V Davalos
PURPOSE: To develop and validate a perfused organ model for characterizing ablations for irreversible electroporation (IRE)-based therapies. MATERIALS AND METHODS: Eight excised porcine livers were mechanically perfused with a modified phosphate-buffered saline solution to maintain viability during IRE ablation. IRE pulses were delivered using 2 monopolar electrodes over a range of parameters, including voltage (1,875-3,000 V), pulse length (70-100 µsec), number of pulses (50-600), electrode exposure (1...
December 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27659702/mr-and-ct-imaging-characteristics-and-ablation-zone-volumetry-of-locally-advanced-pancreatic-cancer-treated-with-irreversible-electroporation
#18
Laurien G P H Vroomen, Hester J Scheffer, Marleen C A M Melenhorst, Marcus C de Jong, Janneke E van den Bergh, Cornelis van Kuijk, Foke van Delft, Geert Kazemier, Martijn R Meijerink
OBJECTIVES: To assess specific imaging characteristics after irreversible electroporation (IRE) for locally advanced pancreatic carcinoma (LAPC) with contrast-enhanced (ce)MRI and ceCT, and to explore the correlation of these characteristics with the development of recurrence. METHODS: Qualitative and quantitative analyses of imaging data were performed on 25 patients treated with percutaneous IRE for LAPC. Imaging characteristics of the ablation zone on ceCT and ceMRI were assessed over a 6-month follow-up period...
September 22, 2016: European Radiology
https://www.readbyqxmd.com/read/27621748/irreversible-electroporation-for-the-treatment-of-pancreatic-neuroendocrine-tumors
#19
Michail Papamichail, Amir Ali, Michail Pizanias, Praveen Peddu, John Karani, Nigel Heaton
BACKGROUNDS/AIMS: Resection or enucleation is currently the treatment of choice for small pancreatic neuroendocrine tumors (NETs). Irreversible electroporation is a novel ablative method that is used for locally advanced pancreatic adenocarcinoma, but little data exists for its use for pancreatic NETs. We report an early experience of IRE for early pancreatic NETs. METHODS: Between April 2014 and March 2015, 3 patients with small (<2 cm) pancreatic NETs were treated with percutaneous IRE...
August 2016: Korean Journal of Hepato-biliary-pancreatic Surgery
https://www.readbyqxmd.com/read/27604035/ablation-of-locally-advanced-pancreatic-cancer-with-percutaneous-irreversible-electroporation-results-of-the-phase-i-ii-panfire-study
#20
Hester J Scheffer, Laurien G P H Vroomen, Marcus C de Jong, Marleen C A M Melenhorst, Babs M Zonderhuis, Freek Daams, Jantien A Vogel, Marc G H Besselink, Cornelis van Kuijk, Jill Witvliet, Marian A E de van der Schueren, Tanja D de Gruijl, Anita G M Stam, Petrousjka M P van den Tol, Foke van Delft, Geert Kazemier, Martijn R Meijerink
Purpose To (a) investigate the safety of percutaneous irreversible electroporation (IRE) for locally advanced pancreatic cancer and (b) evaluate the quality of life (QOL), pain perception, and efficacy in terms of time to local progression, event-free survival, and overall survival (OS). Materials and Methods The study was approved by the local review board (NL42888.029.13). All patients provided written informed consent for study participation, the ablation procedure, and data usage. Between January 2014 and June 2015, 25 patients with histologically proved locally advanced pancreatic cancer 5 cm or smaller (13 women, 12 men; median age, 61 years; age range, 41-78 years) were prospectively included to undergo percutaneous computed tomographic-guided IRE...
September 6, 2016: Radiology
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