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Irreversible electroporation

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https://www.readbyqxmd.com/read/28817909/re-irreversible-electroporation-of-small-renal-masses-suboptimal-oncologic-efficacy-in-an-early-series
#1
M Pilar Laguna
No abstract text is available yet for this article.
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28799842/midterm-safety-and-efficacy-of-irreversible-electroporation-of-malignant-liver-tumors-located-close-to-major-portal-or-hepatic-veins
#2
Martina Distelmaier, Alexandra Barabasch, Philipp Heil, Nils A Kraemer, Peter Isfort, Sebastian Keil, Christiane K Kuhl, Philipp Bruners
Purpose To investigate the efficacy and safety of irreversible electroporation (IRE) in the treatment of hepatic tumors not suitable for thermal ablation (radiofrequency ablation [RFA] or microwave ablation). Materials and Methods This was an institutional review board-approved prospective study in 29 patients (15 men, 14 women; mean age, 63 years ± 12 [standard deviation]) with 43 primary (n = 8) or secondary (n = 35) malignant liver tumors who underwent computed tomography (CT)-guided IRE. All target tumors were located immediately adjacent to major hepatic veins, portal veins, or both; thus, they were not considered suitable for RFA or microwave ablation...
August 11, 2017: Radiology
https://www.readbyqxmd.com/read/28796935/focal-irreversible-electroporation-as-primary-treatment-for-localized-prostate-cancer
#3
Willemien van den Bos, Matthijs J Scheltema, Amila R Siriwardana, Anton M F Kalsbeek, James E Thompson, Francis Ting, Maret Böhm, Anne-Maree Haynes, Ron Shnier, Warick Delprado, Phillip D Stricker
OBJECTIVES: To determine the safety, quality of life (QoL) and short-term oncological outcomes of primary focal IRE for the treatment of localized prostate cancer. To identify potential risk factors for oncological failure. PATIENTS AND METHODS: Patients that met both the consensus guidelines on patient criteria and selection methods for primary focal therapy were eligible for analysis. Focal IRE was performed for organ-confined clinically significant PCa, being high-volume Gleason sum score 6 (ISUP grade 1) or any Gleason sum score 7 (ISUP grade 2-3)...
August 10, 2017: BJU International
https://www.readbyqxmd.com/read/28783621/treatment-of-cancer-in-vitro-using-radiation-and-high-frequency-bursts-of-sub-microsecond-electrical-pulses
#4
Michael B Sano, Olga Volotskova, Lei Xing
High frequency irreversible electroporation (H-FIRE) is an emerging cancer therapy which uses bursts of short duration, alternating polarity, high voltage electrical pulses to focally ablate tumors. Here, we present a preliminary investigation of the combinatorial effects of H-FIRE and ionizing radiation. In vitro cell cultures were exposed to bursts of 500 ns pulses and single radiation doses of 2 or 20 Gy then analyzed for 14 days. H-FIRE and RT appear to induce different delayed cell death mechanisms and in all treatment groups, combinatorial therapy resulted in lower overall viabilities...
August 2, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28781865/treatment-of-lymph-node-metastases-from-gastric-cancer-with-a-combination-of-irreversible-electroporation-and-electrochemotherapy-a-case-report
#5
Nina Klein, Stefan Zapf, Enric Gunther, Michael Stehling
The combination of Irreversible Electroporation and Electrochemotherapy (IRECT) was well tolerated, safe, and had antitumor activity in this case study of a patient with lymph node metastases from gastric cancer. We therefore recommend the consideration of further clinical studies to investigate the treatment of cancerous tissue with IRECT.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28755102/non-surgical-ablative-therapies-for-inoperable-benign-insulinoma
#6
REVIEW
C Mele, A Brunani, B Damascelli, V Tichà, L Castello, G Aimaretti, M Scacchi, P Marzullo
PURPOSE: Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas. The gold-standard therapeutic approach for insulinoma is surgery, which allows for tumor removal, histology and immunochemical analyses. If surgery is not feasible, minimally invasive ablative procedures performed by interventional radiology can lead to partial or complete remission of hormone hypersecretion and tumor control in insulinoma patients. METHODS: We performed a review of existing literature on non-chemotherapeutic/radioactive ablative techniques employed for the treatment of benign, otherwise inoperable, pancreatic insulinoma...
July 28, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28746857/enhancing-irreversible-electroporation-by-manipulating-cellular-biophysics-with-a-molecular-adjuvant
#7
Jill W Ivey, Eduardo L Latouche, Megan L Richards, Glenn J Lesser, Waldemar Debinski, Rafael V Davalos, Scott S Verbridge
Pulsed electric fields applied to cells have been used as an invaluable research tool to enhance delivery of genes or other intracellular cargo, as well as for tumor treatment via electrochemotherapy or tissue ablation. These processes involve the buildup of charge across the cell membrane, with subsequent alteration of transmembrane potential that is a function of cell biophysics and geometry. For traditional electroporation parameters, larger cells experience a greater degree of membrane potential alteration...
July 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28732031/breast-tissue-ablation-with-irreversible-electroporation-in-rabbits-a-safety-and-feasibility-study
#8
Wenlong Zhang, Wanning Wang, Wei Chai, Xiaomei Luo, Jiannan Li, Jian Shi, Liqi Bi, Lizhi Niu
BACKGROUND AND AIM: Irreversible electroporation (IRE) was confirmed to control several solid tumors effectively in vivo. Our preclinical study aimed to assess the feasibility and safety of IRE in the breast of rabbit. METHODS: Thirty New Zealand white rabbits were randomly divided into 3 groups of 10 rabbits (control group, IRE group A, and B). Two mono-electrode needles were inserted into the breast tissue by percutaneous puncture. Electrocardiogram and vital signs were monitored before, during, and after ablation...
2017: PloS One
https://www.readbyqxmd.com/read/28721494/a-comprehensive-characterization-of-parameters-affecting-high-frequency-irreversible-electroporation-lesions
#9
Tyler Miklovic, Eduardo L Latouche, Matthew R DeWitt, Rafael V Davalos, Michael B Sano
Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwave ablation, rely on thermal damage mechanisms which can put critical nerves or vasculature at risk. Irreversible electroporation (IRE) is a minimally invasive, non-thermal technique to destroy tumors. A series of short electric pulses create nanoscale defects in the cell membrane, eventually leading to cell death. Typical IRE protocols deliver a series of 50-100 µs monopolar pulses...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28699509/combination-of-multifunctional-nanoparticles-and-interventional-techniques-makes-each-other-going-further-in-the-field-of-cancer-treatment
#10
Haibo Shao, Tengchuang Ma, Duo Hong, Wenhan Xu, Shuai Li, Ronald S Arellano, Ke Xu
Nano-oncology and interventional oncology are both rapidly emerging fields in loco-regional cancer therapies. Synergistic combination of both fields offers drastic improvement in performance and efficacy of cancer killings. Interventional techniques such selective arterial catheterization, irreversible electroporation (IRE) and radiofrequency ablation (RFA) had dramatically enhance the cancer targetability and anticancer efficacy of nanoparticles (NPs). Furthermore, there is synergistic effect by using different interventional techniques together on NPs assisted cancer treatment...
July 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28687047/the-role-of-irreversible-electroporation-ire-for-locally-advanced-pancreatic-cancer-a-systematic-review-of-safety-and-efficacy
#11
Daniel Ansari, Stina Kristoffersson, Roland Andersson, Magnus Bergenfeldt
OBJECTIVES: Irreversible electroporation (IRE) is a new modality for tumor ablation. Electrodes are placed around the tumor, and a pulsed, direct current with a field strength of 2000 V/cm is delivered. The direct current drives cells into apoptosis and cell death without causing significant heating of the tissues, which spares the extracellular matrix and proteins. The purpose of this review was to evaluate current experience of IRE for the ablation of pancreatic cancer. MATERIAL AND METHODS: We searched PubMed for all studies of IRE in human pancreatic cancer in English reporting at least 10 patients...
July 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28685607/state-of-the-ablation-nation-a-review-of-ablative-therapies-for-cure-in-the-treatment-of-hepatocellular-carcinoma
#12
Umer Salati, Aisling Barry, Frank Y Chou, Roy Ma, David M Liu
Primary liver cancer, mainly hepatocellular carcinoma, is one of the most common malignancies worldwide. Surgical management, either resection or transplantation, is considered definitive treatment, however, less than 20% of patients are ultimately candidates. Thermal ablation modalities such as radiofrequency ablation and microwave ablation have evolved such that these modalities have been applied with curative intent. Moreover, thermal ablation has demonstrated efficacy in treating early-stage tumors and can be offered as first-line treatment in patients with uncomplicated disease...
July 2017: Future Oncology
https://www.readbyqxmd.com/read/28672987/evaluation-of-the-safety-of-irreversible-electroporation-on-the-stomach-wall-using-a-pig-model
#13
Jiannan Li, Jianying Zeng, Jibing Chen, Jian Shi, Xiaomei Luo, Gang Fang, Wei Chai, Wenlong Zhang, Tongjun Liu, Lizhi Niu
The aim of the present study was to evaluate the effects of irreversible electroporation (IRE) on the stomach wall following the direct application of IRE onto the organ surface. IRE ablation was performed in 8 Tibetan mini-pigs, which were randomly assigned into two groups based on their ablated areas: Group A, gastric cardia, fundus of stomach, gastric body and group B, lesser gastric curvature, greater gastric curvature, stomach pylorus. Two IRE needles were placed in the space between the stomach wall and the liver (not inserted into the stomach tissue), and three lesions were created in each pig...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28650421/percutaneous-irreversible-electroporation-for-portal-vein-tumor-thrombus-a-case-report
#14
Weilu Chai, Guo Tian, Tianʼan Jiang
No abstract text is available yet for this article.
June 23, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28643305/-interventional-therapy-of-colorectal-liver-metastasis
#15
Qi Zhang, Gaojun Teng
Colorectal liver metastasis (CRLM) is one of the most difficult and key points in the treatment of colorectal cancer. Approximately 50% to 60% of patients diagnosed as colorectal cancer develops metastasis, and 80% to 90% of CRLM is unresectable. Surgical resection is the first-line treatment for CRLM, while it is only suitable for about 15% patients. Systemic chemotherapy can prolong the survival of CRLM patients, however, a part of CRLM patients are resistant to chemotherapy. With the development of technology and the update of clinical evidence, individual therapy with target drugs and multidisciplinary treatment (MDT) have became a tendency, and minimally invasive interventional therapy has gained more acceptance in the MDT mode of the treatment for CRLM...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28594449/predictive-therapeutic-planning-for-irreversible-electroporation-treatment-of-spontaneous-malignant-glioma
#16
Paulo A Garcia, Bor Kos, John H Rossmeisl, Denis Pavliha, Damijan Miklavčič, Rafael V Davalos
PURPOSE: Irreversible electroporation (IRE) have been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to determine the Peleg-Fermi parameters needed to incorporate pulse number and pulse duration into the therapeutic planning of IRE. METHODS: Seven canine patients were treated with IRE for spontaneous malignant glioma with MRI based treatment planning...
June 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28586250/pain-after-percutaneous-irreversible-electroporation-of-renal-tumors-is-not-dependent-on-tumor-location
#17
Igor Sorokin, Aaron H Lay, Nikitha K Reddy, Noah E Canvasser, Murthy Chamarthy, Jeffrey A Cadeddu
INTRODUCTION: Irreversible electroporation (IRE) is a non-thermal minimally invasive technique that is used to treat small renal masses (SRMs). Prior work has demonstrated greater narcotic requirements after radiofrequency ablation (RFA) for tumors that are closer to body-wall musculature. We hypothesized that pain after IRE is not dependent on tumor location due to the athermal mechanistic action. MATERIALS AND METHODS: A retrospective review of 50 consecutive percutaneous IRE and RFA cases was performed from 2013 to 2014...
August 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28560601/induction-chemotherapy-followed-by-resection-or-irreversible-electroporation-in-locally-advanced-pancreatic-cancer-impala-a-prospective-cohort-study
#18
Jantien A Vogel, Steffi J Rombouts, Thijs de Rooij, Otto M van Delden, Marcel G Dijkgraaf, Thomas M van Gulik, Jeanin E van Hooft, Hanneke W van Laarhoven, Robert C Martin, Annuska Schoorlemmer, Johanna W Wilmink, Krijn P van Lienden, Olivier R Busch, Marc G Besselink
BACKGROUND: Following induction chemotherapy, both resection or irreversible electroporation (IRE) may further improve survival in patients with locally advanced pancreatic cancer (LAPC). However, prospective studies combining these strategies are currently lacking, and available studies only report on subgroups that completed treatment. This study aimed to determine the applicability and outcomes of resection and IRE in patients with nonprogressive LAPC after induction chemotherapy. METHODS: This was a prospective, single-center cohort study in consecutive patients with LAPC (September 2013 to March 2015)...
May 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28558487/irreversible-electroporation-ablation-of-an-unresectable-fibrous-sarcoma-with-2-electrodes-a-case-report
#19
Zilin Qin, Jianying Zeng, Guifeng Liu, Xinan Long, Gang Fang, Zhonghai Li, Kecheng Xu, Lizhi Niu
PURPOSE: To explore the safety and efficacy of irreversible electroporation ablation in unresectable fibrous sarcoma with 2 electrodes. METHODS: A 74-year-old woman with unresectable retroperitoneal malignant fibrous sarcoma was treated with percutaneous irreversible electroporation. Four ablations were performed on the mass, which measured 7.3 × 7.0 × 7.5 cm, with 2 electrodes. RESULTS: A contrast-enhanced computed tomography scan 2 months postoperatively showed that the tumor had reduced to 5...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28557354/modeling-liver-electrical-conductivity-during-hypertonic-injection
#20
Quim Castellví, Patricia Sánchez-Velázquez, Xavier Moll, Enrique Berjano, Anna Andaluz, Fernando Burdío, Bart Bijnens, Antoni Ivorra
Metastases in the liver frequently grow as scattered tumor nodules that neither can be removed by surgical resection nor focally ablated. Previously, we have proposed a novel technique based on irreversible electroporation that may be able to simultaneously treat all nodules in the liver while sparing healthy tissue. The proposed technique requires increasing the electrical conductivity of healthy liver by injecting a hypersaline solution through the portal vein. Aiming to assess the capability of increasing the global conductivity of the liver by means of hypersaline fluids, here, it is presented a mathematical model that estimates the NaCl distribution within the liver and the resulting conductivity change...
May 30, 2017: International Journal for Numerical Methods in Biomedical Engineering
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