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Irreversible electroporation

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https://www.readbyqxmd.com/read/28078482/irreversible-electroporation-as-treatment-of-locally-advanced-and-as-margin-accentuation-in-borderline-resectable-pancreatic-adenocarcinoma
#1
P Marsanic, A Mellano, A Sottile, M De Simone
In recent years, many local ablation technologies based on thermal damage have been used in the treatment of locally advanced pancreatic carcinoma (LAPC) and borderline resectable pancreatic carcinoma (BLRPC). However, they are associated with major complications because of possible vascular and ductal damage. Irreversible electroporation (IRE) is a nonthermal ablation technology that seems safe near vital vascular and ductal structures. IRE could be used as exclusive treatment of LAPC (en situ to IRE) after induction chemotherapy In BLRPC, surgery is not really radical in 6% of patients (microscopic residual) and local recurrences occur in 11-42% of apparent radical resections...
January 11, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28065834/nanosecond-pulsed-electric-fields-trigger-cell-differentiation-in-chlamydomonas-reinhardtii
#2
Fan Bai, Christian Gusbeth, Wolfgang Frey, Peter Nick
Nanosecond pulsed electric fields (nsPEFs) have great potential for biotechnological and medical applications. However, the biological mechanisms causing the cellular responses are still far from understood. We used the unicellular green algae Chlamydomonas reinhardtii as experimental model to dissect the immediate consequences of electroporation from the developmental cellular responses evoked by nsPEFs. We observe that nsPEFs induce a short-term permeabilization of the membrane, accompanied by swelling and oxidative burst...
January 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28052102/irreversible-electroporation-of-the-pancreas-using-parallel-plate-electrodes-in-a-porcine-model-a-feasibility-study
#3
Steffi J E Rombouts, Maarten W Nijkamp, Willemijn P M van Dijck, Lodewijk A A Brosens, Maurits Konings, R van Hillegersberg, Inne H M Borel Rinkes, Jeroen Hagendoorn, Fred H Wittkampf, I Quintus Molenaar
BACKGROUND: Irreversible electroporation (IRE) with needle electrodes is being explored as treatment option in locally advanced pancreatic cancer. Several studies have shown promising results with IRE needles, positioned around the tumor to achieve tumor ablation. Disadvantages are the technical difficulties for needle placement, the time needed to achieve tumor ablation, the risk of needle track seeding and most important the possible occurrence of postoperative pancreatic fistula via the needle tracks...
2017: PloS One
https://www.readbyqxmd.com/read/28033149/partial-gland-ablation-in-the-management-of-prostate-cancer-a-review
#4
Timothy D McClure, Daniel J A Margolis, Jim C Hu
PURPOSE OF REVIEW: The index lesion theory has created a strong interest in partial gland ablation for men with prostate cancer. By only treating the focus of clinically significant disease and avoidance of surrounding periprostatic tissue, one may provide adequate oncologic control with minimal side effects. Accurate identification of the index lesion and effective ablation are critical for satisfactory oncologic outcomes. Herein, we review key ablative techniques used in partial gland ablation...
December 28, 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/28029459/real-time-monitoring-of-cytotoxic-effects-of-electroporation-on-breast-and-colon-cancer-cell-lines
#5
Danijela M Cvetković, Marko N Živanović, Milena G Milutinović, Tijana R Djukić, Miloš D Radović, Aleksandar M Cvetković, Nenad D Filipović, Nebojša D Zdravković
PURPOSE: To study the effects of electroporation on different cell lines. MATERIAL: The effects of electroporation on human breast cancer (MDA-MB-231), human colon cancer (SW-480 and HCT-116), human fibroblast cell line (MRC-5), primary human aortic smooth muscle cells (hAoSMC) and human umbilical vein endothelial cells (HUVEC) were studied. Real-time technology was used for cell viability monitoring. Acridine orange/ethidium bromide assay was applied for cell death type determination...
October 22, 2016: Bioelectrochemistry
https://www.readbyqxmd.com/read/28009979/ablation-of-hepatic-malignant-tumors-with-irreversible-electroporation-a-systematic-review-and-meta-analysis-of-outcomes
#6
Guo Tian, Qiyu Zhao, Fen Chen, Tian'an Jiang, Weilin Wang
BACKGROUND: Irreversible electroporation (IRE) ablation is a new technique that is used to eliminate malignant tumors through nonthermal approaches. OBJECTIVE: The purpose of this review was to evaluate the efficiency of IRE for hepatic malignant tumors. METHODS: A systematic search was performed from PubMed, Embase, Web of science, Scopus and other potential literatures from references in relevant articles July 26th, 2016. Overall estimates of pooled standard mean difference (SMD) with 95% confidence interval (CI) were calculated for the changes of the pre- and post-IRE longest diameter, alkaline phosphatase (ALP), aspartate aminotransferase (AST) and serum total bilirubin levels...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28005508/irreversible-electroporation-disappearance-of-observable-changes-at-imaging-does-not-always-imply-complete-reversibility-of-the-underlying-causal-tissue-changes
#7
Olivier Seror, Clair Poignard, Olivier Gallinato, Rafik Ourabia, Olivier Sutter
No abstract text is available yet for this article.
January 2017: Radiology
https://www.readbyqxmd.com/read/27995093/new-perspectives-in-the-treatment-of-colorectal-metastases
#8
REVIEW
Dominique Elias, Luca Viganò, Franco Orsi, Marta Scorsetti, Tiziana Comito, Jan Lerut, Davide Cosola, Guido Torzilli
BACKGROUND: In recent years, the management of metastatic colorectal cancer has become more aggressive and more multidisciplinary. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy. SUMMARY: Selected patients with synchronous limited peritoneal and liver disease (peritoneal cancer index <12 and <3 liver metastases) can be scheduled for aggressive treatment, including cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, and liver resection...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995086/hepatocellular-carcinoma-the-role-of-interventional-oncology
#9
REVIEW
Matteo Donadon, Luigi Solbiati, Laura Dawson, Aisling Barry, Gonzalo Sapisochin, Paul D Greig, Shuichiro Shiina, Andrea Fontana, Guido Torzilli
BACKGROUND: Hepatocellular carcinoma (HCC) remains a major health issue because of its increasing incidence and because of the complexity of its management. In addition to the traditional potentially curative treatments, i.e., liver transplantation and surgical resection, other new and emerging local therapies have been applied with promising results. SUMMARY: Radiotherapy (RT) and interstitial treatments, such as radiofrequency ablation (RFA), microwave ablation (MWA), and irreversible electroporation (IRE), have recently opened new and interesting treatment scenarios for HCC and are associated with promising results in selected patients...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27993507/percutaneous-image-guided-irreversible-electroporation-for-the-treatment-of-unresectable-locally-advanced-pancreatic-adenocarcinoma
#10
Govindarajan Narayanan, Peter J Hosein, Isabelle C Beulaygue, Tatiana Froud, Hester J Scheffer, Shree R Venkat, Ana M Echenique, Elizabeth C Hevert, Alan S Livingstone, Caio M Rocha-Lima, Jaime R Merchan, Joseph U Levi, Jose M Yrizarry, Riccardo Lencioni
PURPOSE: To describe safety and effectiveness of percutaneous irreversible electroporation (IRE) for treatment of unresectable, locally advanced pancreatic adenocarcinoma (LAPC). MATERIALS AND METHODS: This retrospective study included 50 patients (23 women, 27 men; age range, 46-91 y; median age, 62.5 y) with biopsy-proven, unresectable LAPC who received percutaneous computed tomography (CT)-guided IRE. The primary objective was to assess the safety profile of the procedure; the secondary objective was to determine overall survival (OS)...
December 16, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27977628/percutaneous-irreversible-electroporation-for-pancreatic-vipoma-a-case-report
#11
Lizhi Niu, Jiannan Li, Jianying Zeng, Gang Fang, Liang Zhou, Kecheng Xu, Kai Zhang
The purpose of this study was to investigate the safety and efficacy of irreversible electroporation (IRE) for the management of unresectable pancreatic vasoactive intestinal peptide tumor (VIPoma) in a 34-year-old male patient. The initial symptom was watery diarrhea, which could not be stopped by fasting. Laboratory tests revealed high vasoactive intestinal peptide (VIP) hormone levels, hypokalemia, and metabolic acidosis. Computed tomography examination showed a 6.0 × 5.0-cm, contrast-enhanced lesion in the neck and body of the pancreas and obliteration of the portal vein...
January 2017: Pancreas
https://www.readbyqxmd.com/read/27976527/skin-regeneration-with-all-accessory-organs-following-ablation-with-irreversible-electroporation
#12
Alexander Golberg, Martin Villiger, G Felix Broelsch, Kyle P Quinn, Hassan Albadawi, Saiqa Khan, Michael T Watkins, Irene Georgakoudi, William G Austen, Marianna Bei, Brett E Bouma, Martin C Mihm, Martin L Yarmush
Skin scar formation is a complex process that results in the formation of dense extracellular matrix without normal skin appendages such as hair and glands. The absence of a scarless healing model in adult mammals prevents the development of successful therapies. We show that irreversible electroporation of skin drives its regeneration with all accessory organs in normal adult rats. Pulsed electric fields at 500 V, with 70 µs pulse duration, and 1000 pulses delivered at 3 Hz, applied through two electrodes separated by 2 mm lead to massive cell death...
December 14, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27958223/a-single-institution-experience-with-open-irreversible-electroporation-for-locally-advanced-pancreatic-carcinoma
#13
Li Yan, Yong-Liang Chen, Ming Su, Tian Liu, Kai Xu, Feng Liang, Wan-Qing Gu, Shi-Chun Lu
BACKGROUND: Locally advanced pancreatic carcinoma (LAPC) is characterized by poor prognosis despite recommended concurrent chemoradiotherapy. Irreversible electroporation (IRE) has emerged as a potential option for the management of unresectable pancreatic cancer. This study was conducted to evaluate the safety and short-term efficacy of open IRE for the treatment of LAPC. METHODS: Retrospective data of 25 consecutive patients receiving IRE for T3 lesions from July 2015 to June 2016 at a single center were analyzed...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27956791/percutaneous-ablation-of-pancreatic-cancer
#14
EDITORIAL
Mirko D'Onofrio, Valentina Ciaravino, Riccardo De Robertis, Emilio Barbi, Roberto Salvia, Roberto Girelli, Salvatore Paiella, Camilla Gasparini, Nicolò Cardobi, Claudio Bassi
Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of non-resectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27935553/percutaneous-irreversible-electroporation-ire-of-prostate-cancer-contrast-enhanced-ultrasound-ceus-findings-during-follow%C3%A2-up
#15
L P Beyer, B Pregler, C Nießen, K Michalik, M Haimerl, C Stroszczynski, E M Jung, P Wiggermann
PURPOSE: Irreversible electroporation (IRE) is a focal non-thermal ablation technique that can be used to treat prostate cancer (Pca). The objective was to document the evolution of the volume of the prostate gland and the ablation zone after IRE of Pca. MATERIAL AND METHODS: A retrospective analysis of the image findings of CEUS 1 day, 6 weeks, 3 months and 6 months after IRE of 25 patients was conducted. The prostate gland volumes and the size of the ablation zones were documented...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27933441/multimodality-imaging-to-assess-immediate-response-following-irreversible-electroporation-in-patients-with-malignant-hepatic-tumors
#16
Katsutoshi Sugimoto, Fuminori Moriyasu, Kazuhiro Saito, Yoshiyuki Kobayashi, Takao Itoi
PURPOSE: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS), contrast-enhanced multiphase CT (CECT), and gadoxetic acid-enhanced MRI (EOB-MRI) in identifying residual tumor in the subacute follow-up of patients with malignant hepatic tumors treated by irreversible electroporation (IRE). METHODS: We enrolled 16 patients with 21 hepatic lesions treated by IRE and examined by CEUS and CECT at 1 day after IRE and by EOB-MRI at 7 days after IRE...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27907057/the-effects-of-irreversible-electroporation-on-the-colon-in-a-porcine-model
#17
Xiaomei Luo, Xianjun Liang, Jiannan Li, Jian Shi, Wenlong Zhang, Wei Chai, Jiuping Wu, Shuai Guo, Gang Fang, Xulong Zhou, Jianhua Zhang, Kecheng Xu, Jianying Zeng, Lizhi Niu
BACKGROUND AND AIM: Irreversible electroporation (IRE) is a method of targeted cell ablation which has been suggested as a potential cancer therapy as it leaves structures such as blood vessels and the extracellular matrix intact, thereby allowing the rapid recovery of healthy tissue. Here, we investigated the effects of IRE on the colon in vivo in a porcine model. METHODS: IRE ablation was performed on the colon walls of 12 female Tibet mini-pigs, creating a total of 24 lesions...
2016: PloS One
https://www.readbyqxmd.com/read/27893744/optimization-of-irreversible-electroporation-protocols-for-in-vivo-myocardial-decellularization
#18
Yaniv Zager, David Kain, Natalie Landa, Jonathan Leor, Elad Maor
BACKGROUND: Irreversible electroporation (IRE) is a non-thermal cell ablation approach that induces selective damage to cell membranes only. The purpose of the current study was to evaluate and optimize its use for in-vivo myocardial decellularization. METHODS: Forty-two Sprague-Dawley rats were used to compare myocardial damage of seven different IRE protocols with anterior myocardial infarction damage. An in-vivo open thoracotomy model was used, with two-needle electrodes in the anterior ventricular wall...
2016: PloS One
https://www.readbyqxmd.com/read/27870918/time-dependent-impact-of-irreversible-electroporation-on-pancreas-liver-blood-vessels-and-nerves-a-systematic-review-of-experimental-studies
#19
J A Vogel, E van Veldhuisen, P Agnass, J Crezee, F Dijk, J Verheij, T M van Gulik, M R Meijerink, L G Vroomen, K P van Lienden, M G Besselink
INTRODUCTION: Irreversible electroporation (IRE) is a novel ablation technique in the treatment of unresectable cancer. The non-thermal mechanism is thought to cause mostly apoptosis compared to necrosis in thermal techniques. Both in experimental and clinical studies, a waiting time between ablation and tissue or imaging analysis to allow for cell death through apoptosis, is often reported. However, the dynamics of the IRE effect over time remain unknown. Therefore, this study aims to summarize these effects in relation to the time between treatment and evaluation...
2016: PloS One
https://www.readbyqxmd.com/read/27856215/irreversible-electroporation-for-locally-advanced-pancreatic-cancer
#20
J-P Tasu, G Vesselle, G Herpe, J-P Richer, S Boucecbi, S Vélasco, M Carretier, B Debeane, D Tougeron
Pancreatic adenocarcinoma is one of the solid cancers associated with the poorest prognosis; the only curative treatment remains surgical resection but in most cases, this treatment is not possible because of distant metastasis or local extension. Irreversible electroporation is a new tumor ablation technique, which provides cellular apoptosis without any thermal coagulation effect. This technique helps preserve the ducts, vessels or nerves located in the treatment area. This article reviews the current knowledge regarding the use of electroporation for the treatment of pancreatic adenocarcinoma...
December 2016: Diagnostic and Interventional Imaging
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