keyword
https://read.qxmd.com/read/38529341/extranodal-extension-in-laryngeal-squamous-cell-carcinoma
#21
JOURNAL ARTICLE
Aman M Patel, Sudeepti Vedula, Ariana L Shaari, Hannaan S Choudhry, Andrey Filimonov
OBJECTIVE: Although large retrospective database studies have associated extranodal extension (ENE) with worse survival in several head and neck cancers, the prognostic significance of ENE in laryngeal squamous cell carcinoma (LSCC) remains unclear. Our study examines ENE and overall survival (OS) in LSCC. METHODS: The 2006-2017 National Cancer Database was queried for patients with LSCC undergoing surgical resection and neck dissection, with or without adjuvant therapy...
April 2024: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/38529116/case-report-dostarlimab-for-treatment-of-aggressive-cutaneous-squamous-cell-carcinoma
#22
Sophia Gandarillas, Horace Tang, Bahar Dasgeb
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy with the aggressive cSCC subtype being especially worrisome due to its higher metastatic and mortality rate. An 80-year-old immunocompetent Caucasian man presented with a locally advanced and recurrent cSCC for which he underwent six Mohs surgeries, radiation therapy, and standard immunotherapy treatments. Throughout treatment, the patient's cancer continued to progress across different regions of the face. Biopsy and analysis were performed and showed that the cSCCs had a high mutational burden and oncogenes known to be present in tumors with aggressive nature...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38528913/salivary-mirnas-as-auxiliary-liquid-biopsy-biomarkers-for-diagnosis-in-patients-with-oropharyngeal-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#23
Huy Nguyen, Taichiro Nonaka
Objective: The healthcare system needs a novel approach to improve and diagnose early oropharyngeal squamous cell carcinoma against its low survival rate. We conduct a systematic review and a comprehensive meta-analysis for the diagnostic role of blood and salivary microRNAs (miRNAs). Methods: An unbiased and thorough literature search in PubMed yielded appropriate data from qualified articles regarding different miRNA biomarkers, method of extraction, research location, and year of publication. Stata was used to calculate the sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic curve...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38528774/are-oral-cancers-effectively-palliated-with-radiotherapy-outcomes-of-treatment-with-a-modified-quad-shot-regimen
#24
JOURNAL ARTICLE
Saheli Saha, Indranil Mallick, Prattusha Mukherjee, Santam Chakraborty, Tapesh Bhattacharyya, Moses Arunsingh S, Rimpa Basu Achari, Sanjoy Chatterjee
BACKGROUND: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers. METHODS: Retrospective data of 116 patients treated with a daily dose of 3.6-3.7 Gy in four fractions over 4 days to a total of three courses, with a 2-week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer...
March 25, 2024: Head & Neck
https://read.qxmd.com/read/38528631/head-and-neck-cancer-of-unknown-primary-unveiling-primary-tumor-sites-through-machine-learning-on-dna-methylation-profiles
#25
JOURNAL ARTICLE
Leonhard Stark, Atsuko Kasajima, Fabian Stögbauer, Benedikt Schmidl, Jakob Rinecker, Katharina Holzmann, Sarah Färber, Nicole Pfarr, Katja Steiger, Barbara Wollenberg, Jürgen Ruland, Christof Winter, Markus Wirth
BACKGROUND: The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most common histologic subtype, squamous cell carcinoma, can stem from various tumor primary sites, including the oral cavity, oropharynx, larynx, head and neck skin, lungs, and esophagus. DNA methylation profiles are highly tissue-specific and have been successfully used to classify tissue origin...
March 25, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38528591/lncrna-rasal2-as1-promotes-mettl14-mediated-m6a-methylation-in-the-proliferation-and-progression-of-head-and-neck-squamous-cell-carcinoma
#26
JOURNAL ARTICLE
Meiting Rong, Ming Zhang, Feihong Dong, Ke Wu, Bingkun Cai, Jinrui Niu, Le Yang, Zhongyan Li, Hui-Yi Lu
BACKGROUND: Long non-coding RNAs (lncRNAs) are key regulators of the 6-methyladenosine (m6A) epigenetic modification, playing a role in the initiation and progression of tumors. However, the regulatory mechanisms in head and neck squamous cell carcinoma (HNSCC) remain elusive. In this study, we investigated the molecular regulatory mechanisms of the lncRNA RASAL2-AS1 in the occurrence and development of HNSCC tumors. METHODS: A bioinformatics analysis was conducted to analyze the expression level of RASAL2-AS1 in HNSCC and normal tissues...
March 25, 2024: Cancer Cell International
https://read.qxmd.com/read/38528037/comparative-response-to-pdt-with-methyl-aminolevulinate-and-temoporfin-in-cutaneous-and-oral-squamous-cell-carcinoma-cells
#27
JOURNAL ARTICLE
J Nicolás-Morala, M Alonso-Juarranz, A Barahona, S Terrén, S Cabezas, F Falahat, Y Gilaberte, S Gonzalez, A Juarranz, M Mascaraque
Cutaneous and Head and Neck squamous cell carcinoma (CSCC, HNSCC) are among the most prevalent cancers. Both types of cancer can be treated with photodynamic therapy (PDT) by using the photosensitizer Temoporfin in HNSCC and the prodrug methyl-aminolevulinate (MAL) in CSCC. However, PDT is not always effective. Therefore, it is mandatory to correctly approach the therapy according to the characteristics of the tumour cells. For this reason, we have used cell lines of CSCC (A431 and SCC13) and HNSCC (HN5 and SCC9)...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38526631/disulfidptosis-features-and-prognosis-in-head-and-neck-squamous-cell-carcinoma-patients-unveiling-and-validating-the-prognostic-signature-across-cohorts
#28
JOURNAL ARTICLE
Hao Xue, Qianyu Sun, Heqing Zhang, Hanxiao Huang, Haowei Xue
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a significant health concern with a variable global incidence and is linked to regional lifestyle factors and HPV infections. Despite treatment advances, patient prognosis remains variable, necessitating an understanding of its molecular mechanisms and the identification of reliable prognostic biomarkers. METHODS: We analyzed 959 HNSCC samples and employed batch correction to obtain consistent transcriptomic data across cohorts...
March 25, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38525114/six-week-postoperative-opioid-use-and-pain-following-a-randomized-controlled-trial-evaluating-multimodal-analgesia-for-head-and-neck-free-flap-patients
#29
JOURNAL ARTICLE
Sarah F Wagoner, Amelia S Lawrence, Rahul Alapati, Bryan Renslo, Chelsea S Hamill, Antonio Bon Nieves, Maraya Baumanis, Andrés M Bur, Kiran Kakarala, Kevin J Sykes, Yelizaveta Shnayder
INTRODUCTION: Head and neck malignancy treatment often involves invasive surgeries, necessitating effective postoperative pain control. However, chronic reliance on opioid medications remains a challenge for many patients after surgery. Multimodal analgesia (MMA) within enhanced recovery after surgery protocols has shown success in limiting narcotic pain medications for other cancer types. In a prior study, MMA comprising acetaminophen, ketorolac, gabapentin, and a neurogenic block reduced opioid use in the 7-day postoperative period for major head and neck reconstructive surgery...
April 2024: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/38525111/dickkopf-1-drives-perineural-invasion-via-pi3k-akt-signaling-pathway-in-head-and-neck-squamous-cancer
#30
JOURNAL ARTICLE
Jingyi Wang, Qianying Li, Faya Liang, Xin Du, Pan Song, Taowei Wu, Renhui Chen, Xiaorong Lin, Qinglian Liu, Hai Hu, Ping Han, Xiaoming Huang
Perineural invasion (PNI) leads to the poor prognosis of head and neck squamous cancer (HNSCC) patients, but the mechanism of PNI remains unclear. Dickkopf-1 (DKK1), a secretory protein in the Wnt signaling pathway, was found indeed upregulated in HNSCC cells and tissues. Higher expression of DKK1 was statistically relevant to T stage, N stage, PNI, and poor prognosis of HNSCC. DKK1 overexpression enhanced the migration abilities of cancer cells. Moreover, DKK1-overexpressing cancer cells promoted cancer cells invasion of peripheral nerves in vitro and in vivo...
April 2024: MedComm
https://read.qxmd.com/read/38524770/impact-of-goal-directed-hemodynamic-therapy-on-perioperative-outcomes-in-head-and-neck-free-flap-surgery-a-before-and-after-pilot-study
#31
JOURNAL ARTICLE
Justine Philteos, Stuart A McCluskey, Sophia Emerson, George Djaiani, David Goldstein, Sabri Soussi
BACKGROUND: Free flap reconstruction for head and neck cancer is associated with a high risk of perioperative complications. One of the modifiable risk factors associated with perioperative morbidity is intraoperative hypotension (IOH). The main aim of this pilot study is to determine if the intraoperative use of goal-directed hemodynamic therapy (GDHT) is associated with a reduction in the number of IOH events in this population. METHODS: A before-and-after study design...
March 2024: Health Science Reports
https://read.qxmd.com/read/38524437/identifying-biomarkers-and-therapeutic-targets-by-multiomic-analysis-for-hnscc-precision-medicine-and-healthcare-management
#32
JOURNAL ARTICLE
Hafeeda Kunhabdulla, Ram Manas, Ashok Kumar Shettihalli, Ch Ram Mohan Reddy, Mohammed S Mustak, Raghu Jetti, Riaz Abdulla, Divijendranatha Reddy Sirigiri, Deden Ramdan, Muhammad Imam Ammarullah
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the major types of cancer, with 900,000 cases and over 400,000 deaths annually. It constitutes 3-4% of all cancers in Europe and western countries. As early diagnosis is the key to treating the disease, reliable biomarkers play an important role in the precision medicine of HNSCC. Despite treatments, the survival rate of cancer patients remains unchanged, and this is mainly due to the failure to detect the disease early. Thus, the objective of this study is to identify reliable biomarkers for head and neck cancers for better healthcare management...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524071/the-relationship-of-grade-stage-and-tobacco-usage-in-head-and-neck-squamous-cell-carcinoma-with-p53-pik3ca-and-microrna-profiles
#33
JOURNAL ARTICLE
Kamini Kiran, Nilotpal Chowdhury, Ashok Singh, Manu Malhotra, Sanjeev Kishore
BACKGROUND:  Head and neck squamous cell carcinoma (HNSCC) has multiple epigenetic modifications including post-transcriptional regulation by microRNAs (miRNAs) as well as alterations in molecular pathways due to mutations. Examining these miRNAs and location-specific molecular alterations is essential to understanding the intricacies of HNSCC and directing focused diagnoses and treatments. AIM:  To investigate tobacco-related changes in the expression of miRNAs and proteins with clinicopathological parameters of HNSCC and disease-modifying personal habits like tobacco and alcohol use...
February 2024: Curēus
https://read.qxmd.com/read/38523988/a-rare-case-of-hepatic-schwannoma-in-the-setting-of-schwannomatosis
#34
Minh-Anh Le, Rachel Shi, Justin Geraghty, Vania Zayat, Jignesh Parikh
Schwannomas are benign nerve sheath tumors commonly found in the head, neck, vestibular system, and extremities. Primary hepatic schwannomas are exceptionally rare, with 34 cases reported to date according to our review of the literature. This case report describes a 79-year-old man with a medical history of skin and thyroid cancer, who presented with no clinical symptoms and underwent a follow-up MRI due to an initial scan indicating a suspicious hepatic mass resembling an atypical hemangioma. The MRI revealed a 3...
February 2024: Curēus
https://read.qxmd.com/read/38523915/in-house-manufacturing-of-a-translucent-three-dimensional-model-and-surgical-guide-for-marginal-mandibulectomy
#35
Yutaro Kondo, Masashi Kimura, Mizuki Hyodo, Kengo Hashimoto, Mitsuo Goto
In recent years, intraoperative surgical guides have been widely used in oral and maxillofacial surgery to navigate the resection sites. However, most of them are designed for segmental mandibulectomy and determine only the anterior-posterior cutting sites. In the case of marginal mandibulectomy, the depth and angle of the resection need to be considered in addition to the anterior-posterior cutting site. This report describes a method for creating a translucent mandible model with a colored tumor that enables visualization of the tumor depth and a surgical guide for marginal mandibulectomy with a planned resection angle...
February 2024: Curēus
https://read.qxmd.com/read/38523774/a-tetravalent-nanovaccine-that-inhibits-growth-of-hpv-associated-head-and-neck-carcinoma-via-dendritic-and-t%C3%A2-cell-activation
#36
JOURNAL ARTICLE
Romano Josi, Daniel E Speiser, Simone de Brot, Anne-Cathrine Vogt, Eva M Sevick-Muraca, Genrich V Tolstonog, Martin F Bachmann, Mona O Mohsen
The global incidence of human papillomavirus (HPV) associated head and neck carcinoma is on the rise, in response to this a tetravalent therapeutic vaccine named Qβ-HPVag was developed. This vaccine, utilizing virus-like particles (VLPs) loaded with toll-like receptor ligands and chemically coupled to four HPV16-derived peptides, demonstrated strong anti-tumor effects in a murine head and neck cancer model. Qβ-HPVag impeded tumor progression, increased infiltration of HPV-specific T cells, and significantly improved survival...
April 19, 2024: IScience
https://read.qxmd.com/read/38523630/innovations-in-molecular-biomarkers-and-biomaterial-based-immunotherapies-for-head-neck-cancer
#37
REVIEW
Sarah Anne Wong, Victoria A Manon, Simon Young, Chi T Viet
PURPOSE OF REVIEW: Oral squamous cell carcinoma (OSCC) survival rates have remained stagnant due to a lack of targeted therapies and diagnostic tools. Patient risk is currently determined solely through clinicopathologic features, primarily tumor staging, which lacks the necessary precision to stratify patients by risk and accurately dictate adjuvant treatment. Similarly, conventional OSCC therapies have well-established toxicities and limited efficacy. RECENT FINDINGS: Recent studies show that patient risk can now be assessed using non-invasive techniques, at earlier time points, and with greater accuracy using molecular biomarker panels...
2024: Current Surgery Reports
https://read.qxmd.com/read/38523513/the-gothenburg-trismus-questionnaire-in-china-cross-cultural-adaptation-and-measurement-invariance
#38
JOURNAL ARTICLE
Qian Zhang, Yao Feng, Ying-Hui Zhou, Yi-Fan Yang, Yun-Zhi Feng, Yue Guo
OBJECTIVES: The Gothenburg Trismus Questionnaire (GTQ) is a comprehensive scale for screening and assessing trismus in head and neck (H&N) cancer and temporomandibular joint disorders (TMD) patients. This study aimed to translate and cross-culturally adapt the GTQ in China, and to test its measurement invariance. METHODS: This study comprised 278 H&N cancer, 245 TMD, and 507 control patients. Internal consistency and test-retest reliability were tested to assess the GTQ's reliability...
March 25, 2024: Head & Neck
https://read.qxmd.com/read/38523367/sirolimus-experience-in-adult-patients-with-vascular-malformations
#39
JOURNAL ARTICLE
Arif Akyildiz, Rashad Ismayilov, Deniz Can Guven, Hasan Cagri Yildirim, Omer Denizhan Tatar, Fatih Kus, Elvin Chalabiyev, Fatma Alev Turker, Omer Dizdar, Suayib Yalcin, Halil Ibrahim Gullu
AIM: Sirolimus, a mammalian target of rapamycin inhibitor, inhibits cell growth and proliferation by controlling ribosome biogenesis and protein synthesis in vascular anomalies and cancers. However, most sirolimus studies on vascular anomalies were conducted in the pediatric population, with limited data in adults. In this study, we assessed the effectiveness and safety of sirolimus in adult patients with vascular malformation, a subtype of vascular anomaly. METHODS: We conducted a retrospective analysis of adult vascular malformation patients aged over 16, treated at Hacettepe University Cancer Institute from January 2013 to September 2022...
March 24, 2024: Vascular
https://read.qxmd.com/read/38522260/depth-of-invasion-as-an-independent-prognostic-factor-in-early-stage-oral-cavity-squamous-cell-carcinoma
#40
JOURNAL ARTICLE
Elizabeth S Koh, Abhinav Pandey, Victoria E Banuchi, William I Kuhel, Andrew Tassler, Theresa Scognamiglio, David I Kutler
PURPOSE: To determine the significance of depth of invasion as a predictor of recurrence and mortality in tongue and non-tongue early-stage oral cavity squamous cell carcinoma patients treated with surgery and no postoperative radiotherapy. MATERIALS AND METHODS: 344 patients with oral cavity squamous cell carcinoma from 2005 to 2022 at a tertiary academic medical center were reviewed. Patients were included if they had newly diagnosed, previously untreated T1-T2N0 disease treated with surgery alone that was observed within a follow-up of 5 years...
March 20, 2024: American Journal of Otolaryngology
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