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hypereosinophilic syndrome

Mar Llamas-Velasco, Victoria Alegría, Ángel Santos-Briz, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material...
October 18, 2016: American Journal of Dermatopathology
Christina Stoeckle, Barbara Geering, Shida Yousefi, Saša Rožman, Nicola Andina, Charaf Benarafa, Hans-Uwe Simon
Eosinophils are frequently elevated in pathological conditions and can cause tissue damage and disease exacerbation. The number of eosinophils in the blood is largely regulated by factors controlling their production in the bone marrow. While several exogenous factors, such as interleukin-5, have been described to promote eosinophil differentiation, comparatively little is known about eosinophil-intrinsic factors that control their de novo generation. Here, we report that the small atypical GTPase RhoH is induced during human eosinophil differentiation, highly expressed in mature blood eosinophils and further upregulated in patients suffering from a hypereosinophilic syndrome...
October 14, 2016: Cell Death and Differentiation
Faisal Inayat, Abu Hurairah
The objective of this investigation was to study the gastrointestinal and hepatic involvement in hypereosinophilic syndrome (HES). Gastrointestinal or hepatic involvement is estimated to affect up to one-third of patients with HES, although most of the clinical evidence has been derived from case reports. In literature, HES presenting with hepatitis and jaundice with subsequent development of colitis is a rare clinicopathologic entity. Given the clinical implications, physicians should include HES among differentials in these types of presentations...
August 31, 2016: Curēus
Vivek Thomas
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Anil Mangal, C L Nawal, M K Agarwal, Pradeep Mital
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
S Banerjee, S Ganguly
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Yaram Geetanjali, Shetty Shiva Kumar, Kodliwadmath Ashwin
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Valerie R Madden, Gretchen L Schoeffler
OBJECTIVE: To describe clinically significant thromboembolism as the result of idiopathic hypereosinophilic syndrome (HES) in a dog. CASE SUMMARY: A 3-year-old neutered female Boxer was evaluated for 2-week history of progressive respiratory difficulty and hemoptysis. A brief thoracic ultrasound performed shortly after presentation identified a presumed thrombus within the left atrium. Initial blood work revealed a marked eosinophilia 6.8 × 10(9) /L (6.8 × 10(3) /μL; reference interval, 0...
October 10, 2016: Journal of Veterinary Emergency and Critical Care
Daniel F Boyer
Evaluation of peripheral blood and bone marrow for an indication of persistent eosinophilia can be a challenging task because there are many causes of eosinophilia and the morphologic differences between reactive and neoplastic causes are often subtle or lack specificity. The purpose of this review is to provide an overview of the differential diagnosis for eosinophilia, to recommend specific steps for the pathologist evaluating blood and bone marrow, and to emphasize 2 important causes of eosinophilia that require specific ancillary tests for diagnosis: myeloproliferative neoplasm with PDGFRA rearrangement and lymphocyte-variant hypereosinophilic syndrome...
October 2016: Archives of Pathology & Laboratory Medicine
Jennifer N Saultz, Ben H Kaffenberger, Montoya Taylor, Nyla A Heerema, Rebecca Klisovic
No abstract text is available yet for this article.
September 28, 2016: JAMA Dermatology
Brian A Neff, Stephen G Voss, Matthew L Carlson, Erin K O'Brien, Joseph H Butterfield
OBJECTIVE/HYPOTHESIS: Eosinophilic otitis media (EOM) is a variant of chronic otitis media that is characterized by the development of thick mucoid middle ear effusion, adult onset bronchial asthma, sinonasal polyposis, and aspirin sensitivity. EOM is typically refractory to corticosteroid therapy and surgical intervention. Pegylated interferon (PEG-IFN) has effectively treated hypereosinophilic syndrome in clinical trials; however, the efficacy of this medication for EOM treatment remains undefined...
September 26, 2016: Laryngoscope
Aziz İnan Çelik, Ali Deniz, Mustafa Tangalay, Muhammet Buğra Karaaslan, Emine Bağır Kılıç
Eosinophilic myocarditis (EM) is a rare form of myocarditis that usually presents with heart failure due to eosinophilic infiltration. EM is often a component of hypereosinophilic syndrome (HES). HES is a rare disorder characterized by persistent, marked eosinophilia combined with organ system dysfunction. A 38-year-old man was admitted to emergency services with left inguinal pain and fever, and was hospitalized with diagnosis of nephrolithiasis and urinary tract infection. Intravenous antibiotic therapy of 3 grams meropenem per day and analgesic of 50 mg pethidine per day were administered...
September 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Y-Q He, J-M Zhu, Y-N Zhao, L Liu, H Zeng, P Yang
Idiopathic hypereosinophilic syndrome (IHES) is a rare disease involving multiple vital organ systems. Here we present the case of a 42-year-old man who had IHES associated with simultaneously occurring endomyocardial fibrosis, thrombi, and pulmonary and skin infiltration. The patient was referred to our hospital with electrocardiographic and biochemical cardiac marker abnormalities suggesting acute coronary syndrome. The patient's condition aggravated within one month, but was greatly improved with the combination therapy of glucocorticoids, hydroxyurea, warfarin and standard treatment for heart failure...
March 10, 2016: West Indian Medical Journal
Su-Jun Gao, Wei Wei, Jiang-Tao Chen, Ye-Hui Tan, Cheng-Bao Yu, Mark Robert Litzow, Qiu-Ju Liu
BACKGROUND: Hypereosinophilic syndrome (HES) can be fatal, particularly when eosinophils infiltrate vital organs and/or if extensive thrombosis develops. However there are no standard recommendations for the use of anticoagulant therapy of HES in the setting of thrombosis. METHODS: We herein present a case of a 46-year-old female who presented with marked peripheral eosinophilia with symptoms of multi-organ infiltration and extensive deep venous thrombosis (DVT)...
August 2016: Medicine (Baltimore)
Betul Tavil, Selin Aytaç, Sule Unal, Baris Kuskonmaz, Fatma Gumruk, Mualla Cetin
The aim was to evaluate baseline demographic, clinical, and laboratory characteristics, treatment modalities, and outcome of children with idiopathic hypereosinophilic syndrome (HES) followed up in our center. Children who fulfilled the criteria of idiopathic HES followed up at Hacettepe University Faculty of Medicine, Pediatric Hematology Department between June 2004 and October 2013 were included in this study. Medical records of all children with idiopathic HES were reviewed to obtain regarding data. The mean age of 6 children with idiopathic HES was 52...
October 2016: Journal of Pediatric Hematology/oncology
Jonathan J Kotzin, Sean P Spencer, Sam J McCright, Dinesh B Uthaya Kumar, Magalie A Collet, Walter K Mowel, Ellen N Elliott, Asli Uyar, Michelle A Makiya, Margaret C Dunagin, Christian C D Harman, Anthony T Virtue, Stella Zhu, Will Bailis, Judith Stein, Cynthia Hughes, Arjun Raj, E John Wherry, Loyal A Goff, Amy D Klion, John L Rinn, Adam Williams, Richard A Flavell, Jorge Henao-Mejia
Neutrophils, eosinophils and 'classical' monocytes collectively account for ~70% of human blood leukocytes and are among the shortest-lived cells in the body. Precise regulation of the lifespan of these myeloid cells is critical to maintain protective immune responses while minimizing the deleterious consequences of prolonged inflammation. However, how the lifespan of these cells is strictly controlled remains largely unknown. Here we identify a novel long non-coding RNA (lncRNA) that we termed Morrbid, which tightly controls the survival of neutrophils, eosinophils and 'classical' monocytes in response to pro-survival cytokines...
August 15, 2016: Nature
Yan-Yan Li, Chuang-Wei Zhou, Xiang-Ming Wang, Zhi-Jian Yang
No abstract text is available yet for this article.
November 1, 2016: International Journal of Cardiology
V M Akhunov, A M Akhunova, T P Lavrent'eva
A 49 year old woman with signs of chronic sepsis, hepatomegaly, and high eosinophil count was under long-term examination including consultations with an oncologist, parasitologist, and hematologist, diagnostic laparotomy, and studies of liver biopsies. Seeding blood samples onto Saburo's medium resulted in the growth of Paecilomyces variotii Bainier colonies. Counting mature spherules of the fungus revealed 59000 spherules per 1 mcl compared with the normal value of 1000-6000 which suggested paecilomycotic etiology of sepsis...
2016: Klinicheskaia Meditsina
Mohammed Shafi Abdulsalam, Hari Chandana Ghanta, Prabu Pandurangan, Maya Menon, Sheba S K Jacob
Hypereosinophilic syndrome (HES) is a myeloproliferative disorder characterised by marked peripheral eosinophilia and end organ damage attributable to eosinophilia without secondary cause. Early recognition and treatment are essential to prevent morbidity and mortality. Cytoreduction with Steroids, Hydroxyurea and Imatinib are the main stay of treatment. Molecular studies like Fip1-like-1 fused with platelet derived growth factor receptor alpha (FIP1L1-PDGFRα) etc., are recommended in view of therapeutic implication...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Toshimitsu Tsugu, Yuji Nagatomo, Yoshitake Yamada, Keitaro Mahara, Hiroshi Miura, Mitsushige Murata
Löffler endocarditis is a serious complication of idiopathic hypereosinophilic syndrome characterized by a peculiar type of fibrosing endocarditis. It results in heart failure due to restrictive cardiomyopathy and systemic embolism due to intracardiac thrombus. Here we present a case of a 57-year-old man with Löffler endocarditis concomitant with eosinophilic granulomatosis with polyangiitis. A thrombus in the left ventricular apex was noted on transthoracic echocardiography performed as a screening of left ventricular dilatation, which seemed to be a typical finding of Löffler endocarditis...
October 2016: Journal of Medical Ultrasonics
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