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https://www.readbyqxmd.com/read/29917228/title-reduced-blood-volume-decreases-cerebral-blood-flow-in-preterm-piglets
#1
Yvonne A Eiby, Nicole Y Shrimpton, Ian M R Wright, Eugenie R Lumbers, Paul B Colditz, Greg J Duncombe, Barbara E Lingwood
Preterm infants often have impaired cardiovascular function that may contribute to poor neurodevelopmental outcomes. The study aimed to determine the effects of reduced blood volume on cardiovascular function, including cerebral blood flow in preterm and term piglets. In preterm (97/115d) and term piglets, up to 10% of the estimated blood volume was removed. Removal of blood was ceased if MAP dropped below 20 mmHg. Heart rate, cardiac contractility and relaxation, cardiac output, mean arterial pressure (MAP), and cerebral blood flow were measured at baseline and again after blood volume reduction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917158/introducing-rotavirus-vaccine-to-the-palestinian-territories-the-role-of-public-private-partnerships
#2
W P Rennert, M Hindiyeh, F M Abu-Awwad, H Marzouqa, A Ramlawi
Background: Introducing childhood immunization poses challenges in environments of societal fragility. The Palestinian territories (Pt) are considered 'fragile' because of their lack of political, economic and territorial sovereignty. Poverty is rife, infant mortality high, and diseases associated with overcrowding widespread. Under these circumstances the Rostropovich Vishneskaya Foundation (RVF) has assembled a network of public and private stakeholders to introduce a country-wide rotavirus immunization program...
June 15, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29917126/genetic-susceptibility-to-thirdhand-smoke-induced-lung-cancer-development
#3
Bo Hang, Jian-Hua Mao, Antoine M Snijders
THS, the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents an underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Vulnerable populations are believed to include infants and children living in a smoking household exposed to THS and/or SHS and exposure has been identified as a risk factor for lung cancer later in life. These and future studies will provide novel and important evidence of how early-life exposure to THS affects cancer development and other diseases, which should be useful for framing and enforcing new policies against passive smoking in the the world...
June 16, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29917083/sex-differences-in-reproductive-hormones-during-mini-puberty-in-infants-with-normal-and-disordered-sex-development
#4
T H Johannsen, K M Main, M L Ljubicic, T K Jensen, H R Andersen, M S Andersen, J H Petersen, A-M Andersson, A Juul
CONTEXT: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exists on sex-specific reference ranges for these hormones during early life. OBJECTIVE: To evaluate sex-differences in reproductive hormone concentrations in serum from healthy infants in order to define sex-specific cut-off values and to apply these in infants with DSD...
June 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29916316/a-proposed-nursing-theory-infant-sleep-and-development
#5
Elizabeth M Keys, Karen M Benzies
Although well positioned to work with families of young children, nurses do not yet have a theory that guides practice and research by relating infant sleep to child and family development. The authors of this paper describe a proposed theory that combines Bronfenbrenner's bioecological theory of human development with the Barnard model of parent-child interaction to inform nursing practice and research related to infant sleep and optimizing child and family development. The theory focuses on sustainability of change in family processes and infant sleep, with a goal of optimizing family wellness as the proximal environment for child development...
July 2018: Nursing Science Quarterly
https://www.readbyqxmd.com/read/29916276/association-of-estrogen-progesterone-and-follicle-stimulating-hormone-receptor-polymorphisms-with-in-vitro-fertilization-outcomes
#6
Vijaya Ganesh, Vettriselvi Venkatesan, Teena Koshy, Sanjeeva Nellapalli Reddy, Suruli Muthumuthiah, Solomon Franklin Durairaj Paul
Despite the advances in in vitro fertilization (IVF), the implantation success rate for infertile women remains approximately only 15%. In this study, we sought to determine whether implantation failure after repeated IVF treatments is influenced by the presence of common variants in estrogen α, progesterone and follicle stimulating hormone receptor genes. The study population included three groups of women: group 1 were 50 women who had the transfer of ≥3 high-quality embryos during the IVF procedure without ever having had a clinical pregnancy; group 2 were 50 women who achieved a clinical pregnancy after ≤3 high-quality embryos transfers and group 3 were 50 control subjects who achieved a clinical pregnancy without any fertility therapy that resulted in a one live-born infant...
June 19, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29916044/perinatal-prediction-model-for-severe-intraventricular-hemorrhage-and-the-effect-of-early-postnatal-acidosis
#7
Juyoung Lee, Mee Hong, Sook Kyung Yum, Jung Hyun Lee
PURPOSE: Severe acidosis is one of the strongest predictors of neurologic outcomes in full-term infants with suspected hypoxic-ischemic encephalopathy. However, the relative importance of acidosis as a predictor of outcomes in preterm infants is much less clear. The goals of the present study were to examine the association between postnatal acidosis and severe intraventricular hemorrhage (IVH) and to establish a new score model including acid-base status after birth for predicting the risk of this morbidity...
June 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29916015/mechanism-of-splicing-regulation-of-spinal-muscular-atrophy-genes
#8
Ravindra N Singh, Natalia N Singh
Spinal muscular atrophy (SMA) is one of the major genetic disorders associated with infant mortality. More than 90% cases of SMA result from deletions or mutations of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical copy of SMN1, does not compensate for the loss of SMN1 due to predominant skipping of exon 7. However, correction of SMN2 exon 7 splicing has proven to confer therapeutic benefits in SMA patients. The only approved drug for SMA is an antisense oligonucleotide (Spinraza™/Nusinersen), which corrects SMN2 exon 7 splicing by blocking intronic splicing silencer N1 (ISS-N1) located immediately downstream of exon 7...
2018: Advances in Neurobiology
https://www.readbyqxmd.com/read/29915955/population-pharmacokinetic-modeling-of-remifentanil-in-infants-with-unrepaired-tetralogy-of-fallot
#9
Jing Chang, Yang Shen, Yue Huang, Ying Sun, Mei-Hua Cai, Jing Niu, Li-Ming Zhang, Ji-Jian Zheng, Ma-Zhong Zhang
BACKGROUND: Although there is literature suggesting that pathophysiologic changes in children with congenital heart disease alter the pharmacokinetics of anesthetics and may result in dosage adjustment, limited information exists regarding the pharmacokinetics of remifentanil in infants with unrepaired tetralogy of Fallot (TOF). The objectives of the current analysis were to characterize the population pharmacokinetics of remifentanil in infants, and to evaluate the effects of TOF on remifentanil's pharmacokinetics...
June 19, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29915859/neonatal-subcutaneous-fat-necrosis-with-hypercalcemia-treatment-using-calcitonin
#10
Khouloud A Alsofyani
Subcutaneous fat necrosis of newborn is a form of noninfectious panniculitis. It is an uncommon condition and mostly occurs in full-term infants within first weeks of life that have had a significant condition such as hypoxic-ischemic encephalopathy at the time of birth. Subcutaneous fat necrosis of newborn is usually a self-limiting condition but may be associated with hypercalcemia, which may lead to life threatening levels. Hypercalcemia is a significant reason of subcutaneous fat necrosis and needs an intervention involving hyperhydration, calcitonin, diuretics, steroids and sometimes bisphosphonate in resistant cases...
June 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29915854/perinatal-and-neonatal-morbidity-among-infants-of-diabetic-mothers-at-a-university-hospital-in-central-saudi-arabia
#11
Abdulrahman M Al-Nemri, Fahd Alsohime, Asfaq H Shaik, Ghasan A El-Hissi, Mohammed I Al-Agha, Nada F Al-Abdulkarim, Sarar Mohamed
OBJECTIVES: To determine the perinatal and neonatal morbidity related to diabetes associated with pregnancy. METHODS: This is a prospective cohort study conducted at a tertiary university hospital in Central Saudi Arabia. All neonates born to mothers with pregnancy associated diabetes between July 2014 and June 2015 were recruited for the purpose of this study. Infants born at 23 weeks or less, infants who died within 3 hours of delivery, twins, and unbooked pregnant ladies were excluded from the study...
June 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29915742/prevalence-and-determinants-of-undernutrition-among-children-under-5-year-old-in-rural-areas-a-cross-sectional-survey-in-north-sudan
#12
Amel Abdalrhim Sulaiman, Sarra O Bushara, Wadie M Elmadhoun, Sufian K Noor, Mutaz Abdelkarim, Ilham Nasr Aldeen, Meissa M Osman, Ahmed O Almobarak, Heitham Awadalla, Mohamed H Ahmed
Background: Child malnutrition is a major public health problem in developing countries. Therefore, the aim of this study was to estimate the prevalence of undernutrition among children <5 years in River Nile state (RNS) in North Sudan. Subjects and Methods: A cross-sectional household survey was done in four localities in RNS. Using Multistage Cluster sampling, 1635 under 5 years' children had participated. Pretested questionnaire and anthropometric measures were used during data collection...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915737/effectiveness-of-iron-fortified-infant-cereals-on-hemoglobin-levels-of-children-aged-12-24-months-a-cross-sectional-study-from-new-delhi-india
#13
Arun Fotedar, Jasjit Singh Bhasin, Ashok Chakravarty, Avinash Kulkarni, Gaurav Bhalla, Fahmina Anwar, Shashidhar Rao
Introduction: Iron deficiency anemia represents 3rd largest disease burden, with an estimated 6.9 billion disability-adjusted life years. Iron-fortified cereals (IFIC) can contribute substantially in preventing iron deficiency anemia and maintaining an adequate body iron status. The aim of this study is to assess the effectiveness of IFIC intake along with other complementary food/s on the hemoglobin (hb) level of children from 12 to 24 months of age. Materials and Methods: A cross-sectional study was conducted from November 2015 to February 2016 in three pediatric outpatient clinics of New Delhi, India...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915732/prevalent-infant-feeding-practices-among-the-mothers-presenting-at-a-tertiary-care-hospital-in-garhwal-himalayan-region-uttarakhand-india
#14
Vyas Kumar Rathaur, Monika Pathania, Charu Pannu, Anand Jain, Minakshi Dhar, Nitish Pathania, Rahul Goel
Introduction: There is paucity of studies on infant feeding practices from the rural areas of garhwal Himalayas of the state of uttarakhand. The present study was designed to assess the infant feeding practices in Garhwal region. Infant feeding practices have significant implications on a child's health. Early nutritional status especially during the first year of life has been shown to have a significant effect on child health and development. Optimal infant feeding practices are crucial for nutritional status, growth, development, health, and ultimately the survival of infants and young children...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915715/functional-implications-of-a-rare-variant-in-the-sodium-channel-%C3%AE-1b-subunit-scn1b-in-a-5-month-old-male-sudden-infant-death-syndrome-case
#15
Jacqueline Neubauer, Jean-Sébastien Rougier, Hugues Abriel, Cordula Haas
No abstract text is available yet for this article.
May 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29915647/recurrent-spontaneous-pneumothorax-in-pregnancy-a-case-report-and-review-of-literature
#16
Noman Lateef, Mustafa Dawood, Karn Sharma, Abubakar Tauseef, Muhammad Asadullah Munir, Erin Godbout
Spontaneous pneumothorax in pregnancy is a rare and life-threatening condition. In this report, a case of spontaneous pneumothorax occurring at 34 weeks' gestation in a healthy 34-year-old primigravida is described. She had typical complaints of chest pain and dyspnoea and diagnosis was made by chest X-ray which showed an extensive pneumothorax in the right side. Pneumothorax recurred twice over approximately three weeks. A caesarean section secondary to small pelvic parameters was scheduled with the chest tube in situ and a healthy 2...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915592/neonatal-immunity-respiratory-virus-infections-and-the-development-of-asthma
#17
REVIEW
Katherine H Restori, Bharat T Srinivasa, Brian J Ward, Elizabeth D Fixman
Infants are exposed to a wide range of potential pathogens in the first months of life. Although maternal antibodies acquired transplacentally protect full-term neonates from many systemic pathogens, infections at mucosal surfaces still occur with great frequency, causing significant morbidity and mortality. At least part of this elevated risk is attributable to the neonatal immune system that tends to favor T regulatory and Th2 type responses when microbes are first encountered. Early-life infection with respiratory viruses is of particular interest because such exposures can disrupt normal lung development and increase the risk of chronic respiratory conditions, such as asthma...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915520/gender-role-beliefs-work-family-conflict-and-father-involvement-after-the-birth-of-a-second-child
#18
Patty X Kuo, Brenda L Volling, Richard Gonzalez
A major task for parents during the transition to second-time parenthood is to help their firstborn adjust to their new roles as siblings. Increased father involvement has been theorized to be protective for firstborn adjustment. Fathers, however, are under increasing pressure to balance both work and family responsibilities. Here we evaluate fathers' relative involvement in two-child families as a function of family structure, gender role beliefs, and work-family conflict in 222 dual- and single-earner families from the Midwestern region of the United States after the birth of a second child...
April 2018: Psychology of Men & Masculinity
https://www.readbyqxmd.com/read/29915375/frequency-and-duration-of-phototherapy-in-preterm-infants-35-weeks-gestation
#19
Devashis Mukherjee, Mary Coffey, M Jeffrey Maisels
OBJECTIVE: To evaluate the frequency, age at phototherapy (PT) initiation, and duration of PT use in infants 230/7 to 346/7 weeks of gestation in two neonatal intensive care units (NICUs) over 4 time periods. STUDY DESIGN: We reviewed the charts of all infants born at 230/7 -346/7 weeks of gestational age (GA) and admitted to the NICUs of two hospitals between January 2009 and September 2015. We calculated the proportion of infants who received PT and the total duration of PT exposure...
June 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29915374/maternal-overweight-and-obesity-increase-the-risk-of-fetal-acidosis-during-labor
#20
Stefan Johansson, Anna Sandström, Sven Cnattingius
OBJECTIVE: To investigate whether maternal overweight and obesity increased the risk of fetal acidosis measured in umbilical cord arterial blood after delivery. STUDY DESIGN: Population-based cohort study of 84,785 term (≥37 weeks) infants. Logistic regression was used to estimate risks of fetal acidosis in umbilical cord arterial blood. Fetal acidosis was defined as pH <7.10 or as pH <1st percentile on a normal reference curve. RESULT: Risks of fetal acidosis increased, regardless of definition, with maternal overweight and obesity severity...
June 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
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