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"peak detection"

Adrian Derungs, Corina Schuster-Amft, Oliver Amft
Background: Longitudinal movement parameter analysis of hemiparetic patients over several months could reveal potential recovery trends and help clinicians adapting therapy strategies to maximize recovery outcome. Wearable sensors offer potential for day-long movement recordings in realistic rehabilitation settings including activities of daily living, e.g., walking. The measurement of walking-related movement parameters of affected and non-affected body sides are of interest to determine mobility and investigate recovery trends...
2018: Frontiers in Bioengineering and Biotechnology
Gerasimos Bastas, Joshua J Fleck, Richard A Peters, Karl E Zelik
BACKGROUND: Inertial Measurement Unit (IMU)-based gait analysis algorithms have previously been validated in healthy controls. However, little is known about the efficacy, performance, and applicability of these algorithms in clinical populations with gait deviations such as lower limb prosthesis users (LLPUs). RESEARCH QUESTION: To compare the performance of 3 different IMU-based algorithms to demarcate steps from LLPUs. METHODS: We used a single IMU sensor affixed to the midline lumbopelvic region of 17 transtibial (TTA), 16 transfemoral (TFA) LLPUs, and 14 healthy controls (HC)...
May 22, 2018: Gait & Posture
Satu Rajala, Harri Lindholm, Tapio Taipalus
OBJECTIVE: The aim here was to compare photoplethysmogram (PPG) signals measured from wrist and finger and evaluate if wrist PPG signal could be used to calculate pulse arrival time (PAT), the time delay between electrocardiogram (ECG) R peak and a feature (peak, foot, 1. derivative peak) in PPG signal. Also, the correlation between pulse wave velocity (rePWV, defined as PWV from ECG R peak to extremity) and systolic blood pressure was studied. APPROACH: 30 subjects were measured at rest by a trained research nurse...
May 24, 2018: Physiological Measurement
Zuo-Fei Yuan, Simone Sidoli, Dylan M Marchione, Johayra Simithy, Kevin A Janssen, Mary R Szurgot, Benjamin A Garcia
Epigenetics has become a fundamental scientific discipline with various implications for biology and medicine. Epigenetic marks, mostly DNA methylation and histone post-translational modifications (PTMs), play important roles in chromatin structure and function. Accurate quantification of these marks is an ongoing challenge due to the variety of modifications and their wide dynamic range of abundance. Here, we present EpiProfile 2.0, an extended version of our 2015 software (v1.0) for accurate quantification of histone peptides based on liquid chromatography - tandem mass spectrometry (LC-MS/MS) analysis...
May 23, 2018: Journal of Proteome Research
Tatsuya Kawaguchi, Emma Tabe Eko Niba, Abdul Qawee Mahyoob Rani, Yoshiyuki Onishi, Makoto Koizumi, Hiroyuki Awano, Masaaki Matsumoto, Masashi Nagai, Shinobu Yoshida, Sachiko Sakakibara, Naoyuki Maeda, Osamu Sato, Hisahide Nishio, Masafumi Matsuo
BACKGROUND: Dystrophin Dp71 is one of the isoforms produced by the DMD gene which is mutated in patients with Duchenne muscular dystrophy (DMD). Although Dp71 is expressed ubiquitously, it has not been detected in normal skeletal muscle. This study was performed to assess the expression of Dp71 in human skeletal muscle. METHODS: Human skeletal muscle RNA and tissues were obtained commercially. Mouse skeletal muscle was obtained from normal and DMDmdx mice. Dp71 mRNA and protein were determined by reverse-transcription PCR and an automated capillary Western assay system, the Simple Western, respectively...
May 23, 2018: International Journal of Molecular Sciences
Vadim Gliner, Joachim Behar, Yael Yaniv
BACKGROUND: In parallel to the introduction of mobile communication devices with high computational power and internet connectivity, high-quality and low-cost health sensors have also become available. However, although the technology does exist, no clinical mobile system has been developed to monitor the R peaks from electrocardiogram recordings in real time with low false positive and low false negative detection. Implementation of a robust electrocardiogram R peak detector for various arrhythmogenic events has been hampered by the lack of an efficient design that will conserve battery power without reducing algorithm complexity or ease of implementation...
May 22, 2018: JMIR MHealth and UHealth
Chen Wang, Thierry Pun, Guillaume Chanel
Remotely measuring physiological activity can provide substantial benefits for both the medical and the affective computing applications. Recent research has proposed different methodologies for the unobtrusive detection of heart rate (HR) using human face recordings. These methods are based on subtle color changes or motions of the face due to cardiovascular activities, which are invisible to human eyes but can be captured by digital cameras. Several approaches have been proposed such as signal processing and machine learning...
2018: Frontiers in Bioengineering and Biotechnology
Dikai Zhu, Juan Hui, Nelson Rowell, Yuanyuan Liu, Queena Y Chen, Tristan Steegemans, Hongsong Fan, Meng Zhang, Kui Yu
Colloidal semiconductor magic-size clusters (MSCs), a crucial link between molecular and bulk materials, have attracted attention in the past three decades. However, the identification of their nonbandgap electronic transitions via optical absorption has been challenging due to the possible presence of other-bandgap ensembles in synthetic batches. For CdSe MSC-415, referred to as the optical absorption (1S(e)-1S3/2 (h)) in nanometers of wavelength, we report our exploration on the origin of two commonly documented absorption peaks at 381 and 351 nm...
May 15, 2018: Journal of Physical Chemistry Letters
Zengding Liu, Ji Chen, Minfang Tang
Aiming at the defects that the traditional pulse transit time (PTT) detection methods are sensitive to changes in photoplethysmography (PPG) signal and require heavy computation, we proposed a new algorithm to detect PTT based on waveform time domain feature and dynamic difference threshold. We calculated the PTT by using dynamic difference threshold method to detect the R-waves of electrocardiogram (ECG), shortening the main peak detection range in PPG signal according to the characteristics of the waveform time domain, and using R wave to detect the main peak of PPG signal...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Juhua Yu, Jianyun Zhang, Qiuwen Chen, Wenyong Yu, Liuming Hu, Wenqing Shi, Jicheng Zhong, Weixia Yan
Biogeochemical cycling of nitrous oxide (N2 O), a significant greenhouse gas (GHG), can influence global climate change. The production and emission of N2 O mediated by hydrological regimes is particularly active in water level fluctuation zones (WLFZs). However, the hydrological mechanisms affecting N2 O transformation and production across the water-sediment micro-interface remain unclear. In this study, intact sediment cores from the WLFZs of the Three Gorges Reservoir (TGR) were incubated for 24 days in a laboratory microcosm to identify the effects of the flooding-drying processes on the yield and emission of N2 O...
May 9, 2018: Environmental Science and Pollution Research International
Grace Wusk, Hampton Gabler
This study demonstrates the feasibility of using a seat sensor designed for occupant classification from a production passenger vehicle to measure an occupant’s respiration rate (RR) and heart rate (HR) in a laboratory setting. Relaying occupant vital signs after a crash could improve emergency response by adding a direct measure of the occupant state to an Advanced Automatic Collision Notification (AACN) system. Data was collected from eleven participants with body weights ranging from 42 to 91 kg using a Ford Mustang passenger seat and seat sensor...
May 8, 2018: Sensors
Shijuan Yan, Wenjie Huang, Jiadong Gao, Hua Fu, Jun Liu
Seed storability is an important trait for crop breeding, however, the mechanism underlying seed storability remains largely unknown. Here, a mass spectrometry-based comparative metabolomic study was performed for rice seeds before and after 24-month natural storage between two hybrid rice cultivars, IIYou 998 (IIY) with low storability and BoYou 998 (BY) with relative high storability. A total of 48 metabolites among 90 metabolite peaks detected were conclusively identified, and most of them are involved in the primary metabolism...
May 1, 2018: Plant Physiology and Biochemistry: PPB
Yan Ni, Mingming Su, Yunping Qiu, Wei Jia, Xiuxia Du
No abstract text is available yet for this article.
May 15, 2018: Analytical Chemistry
Naz Hasan Huda, Bhawna Gauri, Heather A E Benson, Yan Chen
The objective of this study was to develop and validate a method for quantitative analysis of rivastigmine hydrogen tartrate (RHT) in dual-ligand polymeric nanoparticle formulation matrices, drug release medium, and cellular transport medium. An isocratic HPLC analysis method using a reverse phase C18 column and a simple mobile phase without buffer was developed, optimised, and fully validated. Analyses were carried out at a flow rate of 1.5 mL/min at 50°C and monitored at 214 nm. This HPLC method exhibited good linearity, accuracy, and selectivity...
2018: Journal of Analytical Methods in Chemistry
Emily Goren, Peng Liu, Chao Wang, Chong Wang
Motivation: ChIP-seq experiments that are aimed at detecting DNA-protein interactions require biological replication to draw inferential conclusions, however there is no current consensus on how to analyze ChIP-seq data with biological replicates. Very few methodologies exist for the joint analysis of replicated ChIP-seq data, with approaches ranging from combining the results of analyzing replicates individually to joint modeling of all replicates. Combining the results of individual replicates analyzed separately can lead to reduced peak classification performance compared to joint modeling...
April 19, 2018: Bioinformatics
Ashish Kumar, Manjeet Kumar, Rama Komaragiri
Bradycardia can be modulated using the cardiac pacemaker, an implantable medical device which sets and balances the patient's cardiac health. The device has been widely used to detect and monitor the patient's heart rate. The data collected hence has the highest authenticity assurance and is convenient for further electric stimulation. In the pacemaker, ECG detector is one of the most important element. The device is available in its new digital form, which is more efficient and accurate in performance with the added advantage of economical power consumption platform...
April 19, 2018: Journal of Medical Systems
Mahsa Moein, Kamil Grzyb, Teresa Gonçalves Martins, Shinya Komoto, Francesca Peri, Alexander Crawford, Aymeric Fouquier d'Herouel, Alexander Skupin
Summary: Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+ signals are not purely oscillatory as widely assumed but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present CaSiAn (Calcium Signaling Analyzer), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner...
April 12, 2018: Bioinformatics
Min Sun Lee, Seung Kwan Kang, Jae Sung Lee
Here, we propose a novel method to identify inter-crystal scattering (ICS) events from a PET detector that is even applicable to light-sharing designs. In the proposed method, the detector observation was considered as a linear problem and ICS events were identified by solving this problem. Two ICS identification methods were suggested for solving the linear problem, pseudoinverse matrix calculation and convex constrained optimization. The proposed method was evaluated based on simulation and experimental studies...
June 7, 2018: Physics in Medicine and Biology
Xiaolu Li, Bingwei Yang, Xinhao Xie, Duan Li, Lijun Xu
Time of flight (TOF) based light detection and ranging (LiDAR) is a technology for calculating distance between start/stop signals of time of flight. In lab-built LiDAR, two ranging systems for measuring flying time between start/stop signals include time-to-digital converter (TDC) that counts time between trigger signals and analog-to-digital converter (ADC) that processes the sampled start/stop pulses waveform for time estimation. We study the influence of waveform characteristics on range accuracy and precision of two kinds of ranging system...
April 10, 2018: Sensors
Weifang Zhang, Yingwu Li, Bo Jin, Feifei Ren, Hongxun Wang, Wei Dai
A Fiber Bragg Grating (FBG) interrogation system with a self-adaption threshold peak detection algorithm is proposed and experimentally demonstrated in this study. This system is composed of a field programmable gate array (FPGA) and advanced RISC machine (ARM) platform, tunable Fabry-Perot (F-P) filter and optical switch. To improve system resolution, the F-P filter was employed. As this filter is non-linear, this causes the shifting of central wavelengths with the deviation compensated by the parts of the circuit...
April 8, 2018: Sensors
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