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"peak detection"

Min Sun Lee, Seung Kwan Kang, Jae Sung Lee
Here, we proposed a novel method to identify inter-crystal scattering (ICS) events from a PET detector that is even applicable to light sharing designs. In the proposed method, the detector observation was considered as a linear problem and ICS events were identified by solving the linear problem. Three ICS identification methods were suggested to solve the linear problem 1) maximum peak detection, 2) pseudoinverse matrix calculation, and 3) convex constrained optimization. The proposed method was evaluated based on simulation and experimental studies...
April 16, 2018: Physics in Medicine and Biology
Xiaolu Li, Bingwei Yang, Xinhao Xie, Duan Li, Lijun Xu
Time of flight (TOF) based light detection and ranging (LiDAR) is a technology for calculating distance between start/stop signals of time of flight. In lab-built LiDAR, two ranging systems for measuring flying time between start/stop signals include time-to-digital converter (TDC) that counts time between trigger signals and analog-to-digital converter (ADC) that processes the sampled start/stop pulses waveform for time estimation. We study the influence of waveform characteristics on range accuracy and precision of two kinds of ranging system...
April 10, 2018: Sensors
Weifang Zhang, Yingwu Li, Bo Jin, Feifei Ren, Hongxun Wang, Wei Dai
A Fiber Bragg Grating (FBG) interrogation system with a self-adaption threshold peak detection algorithm is proposed and experimentally demonstrated in this study. This system is composed of a field programmable gate array (FPGA) and advanced RISC machine (ARM) platform, tunable Fabry-Perot (F-P) filter and optical switch. To improve system resolution, the F-P filter was employed. As this filter is non-linear, this causes the shifting of central wavelengths with the deviation compensated by the parts of the circuit...
April 8, 2018: Sensors
Michael A Marciano, Victoria R Williamson, Jonathan D Adelman
The interpretation of genetic profiles require a robust and reliable method to discriminate true allelic information from noise, regardless of the instrumentation or methods used. Traditionally, static peak detection thresholds (analytical thresholds) have been applied to capillary electrophoresis generated data to distinguish the true allelic peaks from noise. While the rigid nature of these thresholds attempts to conservatively account for baseline variability across instrument runs, samples, capillaries, dye-channels, injection times, and voltage, its static nature is unable to adapt, leading to a loss of allelic information that exists below the threshold...
March 31, 2018: Forensic Science International. Genetics
Chung-Ki Wong, Qingfei Luo, Vadim Zotev, Raquel Phillips, Kam Wai Clifford Chan, Jerzy Bodurka
BACKGROUND: In simultaneous EEG-fMRI, identification of the period of cardioballistic artifact (BCG) in EEG is required for the artifact removal. Recording the electrocardiogram (ECG) waveform during fMRI is difficult, often causing inaccurate period detection. NEW METHOD: Since the waveform of the BCG extracted by independent component analysis (ICA) is relatively invariable compared to the ECG waveform, we propose a multiple-scale peak-detection algorithm to determine the BCG cycle directly from the EEG data...
March 31, 2018: Journal of Neuroscience Methods
Meritxell Navarro-Reig, Carmen Bedia, Romà Tauler, Joaquim Jaumot
The increasing complexity of omics research has encouraged the development of new instrumental technologies able to deal with these challenging samples. In this way, the rise of multidimensional separations should be highlighted due to the massive amounts of information that provide with an enhanced analyte determination. Both proteomics and metabolomics benefit from this higher separation capacity achieved when different chromatographic dimensions are combined, either in LC or GC. However, this vast quantity of experimental information requires the application of chemometric data analysis strategies to retrieve this hidden knowledge, especially in the case of non-targeted studies...
April 3, 2018: Proteomics
Pooja Sabherwal, Latika Singh, Monika Agrawal
In this paper, a novel algorithm for the accurate detection of QRS complex by combining the independent detection of R and S peaks, using fusion algorithm is proposed. R peak detection has been extensively studied and is being used to detect the QRS complex. Whereas, S peaks, which is also part of QRS complex can be independently detected to aid the detection of QRS complex. In this paper, we suggest a method to first estimate S peak from raw ECG signal and then use them to aid the detection of QRS complex...
March 30, 2018: Cardiovascular Engineering and Technology
Juan Prada, Manju Sasi, Corinna Martin, Sibylle Jablonka, Thomas Dandekar, Robert Blum
Local and spontaneous calcium signals play important roles in neurons and neuronal networks. Spontaneous or cell-autonomous calcium signals may be difficult to assess because they appear in an unpredictable spatiotemporal pattern and in very small neuronal loci of axons or dendrites. We developed an open source bioinformatics tool for an unbiased assessment of calcium signals in x,y-t imaging series. The tool bases its algorithm on a continuous wavelet transform-guided peak detection to identify calcium signal candidates...
March 30, 2018: PLoS Computational Biology
Fabio Forcolin, Ruben Buendia, Stefan Candefjord, Johan Karlsson, Bengt Arne Sjöqvist, Anna Anund
OBJECTIVE: Appropriate preprocessing for detecting and removing outlier heartbeats and spectral transformation is essential for deriving heart rate variability (HRV) indices from cardiac monitoring data with high accuracy. The objective of this study is to evaluate agreement between standard preprocessing methods for cardiac monitoring data used to detect outlier heartbeats and perform spectral transformation, in relation to estimating HRV indices for drivers at different stages of sleepiness...
February 28, 2018: Traffic Injury Prevention
Diana Escalona-Vargas, Hau-Tieng Wu, Martin G Frasch, Hari Eswaran
Fetal magnetocardiography (fMCG) provides accurate and reliable measurements of electrophysiological events in the fetal heart and is capable of studying fetuses with congenital heart diseases. A variety of techniques exist to extract the fMCG signal with the demand for non-invasively obtained fetal cardiac information. To the best of our knowledge, there is no comparative study published in the field as to how the various extraction algorithms perform. We perform a comparative study of the ability of five methods to extract the fMCG using real biomagnetic signals, two of those methods are applied to real fMCG data for the first time...
March 26, 2018: Cardiovascular Engineering and Technology
Wenji Xu, Gangjun Luo, Fengyang Yu, Qingxiang Jia, Yang Zheng, Xiaoying Bi, Jiajun Lei
Iris dichotoma with different flower colors and I. domestica are beardless wild irises belonging to the family Iridaceae that bloom in the summer and have long flowering periods. In this study, we collected three accessions of I. dichotoma with violet, yellow, and white flowers, respectively, in China, and crossed them with I. domestica individuals. The flower color of the hybrids derived from these crosses was categorized into eight groups: violet, purple, brown, orange, red, pink, yellow, and white. From this population, 45 individuals were selected for analysis, and their fully expanded inner and outer perianths were harvested for extraction of anthocyanins...
March 15, 2018: Phytochemistry
Veronika Sele, Robin Ørnsrud, Jens J Sloth, Marc H G Berntssen, Heidi Amlund
Selenium (Se) is an essential element for animals, including fish. Due to changes in feed composition for Atlantic salmon (Salmo salar), it may be necessary to supplement feeds with Se. In the present work, the transfer of Se and Se species from feed to muscle of Atlantic salmon fed Se supplemented diets was studied. Salmon were fed basal fish feed (0.35 mg Se/kg and 0.89 mg Se/kg feed), or feed supplemented either with selenised yeast or sodium selenite, at low (1-2 mg Se/kg feed) and high (15 mg Se/kg feed) levels, for 12 weeks...
May 2018: Journal of Trace Elements in Medicine and Biology
Henri De Vroey, Filip Staes, Ive Weygers, Evie Vereecke, Jos Vanrenterghem, Jan Deklerck, Geert Van Damme, Hans Hallez, Kurt Claeys
BACKGROUND: The use of inertial measurement units for the evaluation of temporal parameters of gait has been studied in many populations. However, currently no studies support the use of inertial measurement units for this purpose in the knee arthroplasty population. The objective of the present study was to investigate the agreement between an inertial measurement and camera based system for the assessment of temporal gait parameters in a knee arthroplasty population. METHODS: Sixteen knee arthroplasty patients performed 3 gait trials at a self-selected speed along a 6 m walk-way...
March 7, 2018: Clinical Biomechanics
Lu Gao, Yan Gu, Feng Chen, Qing Wei Ma
OBJECTIVE: To develop standard experimental methods to minimise technical variance in matrix preparation for MALDI-TOF MS (matrix-assisted laser desorption/ionisation time-offlight) profiling. METHODS: Matrix factors in saliva and serum samples of 20 healthy volunteers were examined, assuring their peptide components using seven different matrix type/preparation methods, HCCA(a-cyano-4-hydroxycinnamic acid)/SM(sample/matrix), SA(sinapinic acid)/DD(dried droplet), SA/SM, DHB(2...
2018: Chinese Journal of Dental Research
Akiyoshi Hirayama, Hiroshi Abe, Nozomi Yamaguchi, Sho Tabata, Masaru Tomita, Tomoyoshi Soga
A sheath-flow interface is the most common ionization technique in CE-ESI-MS. However, this interface dilutes the analytes with the sheath liquid and decreases the sensitivity. In this study, we developed a sheathless CE-MS interface to improve sensitivity. The interface was fabricated by making small crack approximately 2 cm from the end of a capillary column fixed on a plastic plate, and then covering the crack with a dialysis membrane to prevent metabolite loss during separation. A voltage for CE separation was applied between the capillary inlet and the buffer reservoir...
March 1, 2018: Electrophoresis
Giovanna Maria Dimitri, Shruti Agrawal, Adam Young, Joseph Donnelly, Xiuyun Liu, Peter Smielewski, Peter Hutchinson, Marek Czosnyka, Pietro Lio, Christina Haubrich
OBJECTIVES: The detection of increasing intracranial pressure (ICP) is important in preventing secondary brain injuries. Before mean ICP increases critically, transient ICP elevations may be observed. We have observed ICP transients of less than 10 min duration ,which occurred simultaneously with transient increases in heart rate (HR). These simultaneous events in HR and ICP suggest a direct interaction or communication between the heart and the brain. METHODS: This chapter describes four mathematical methods and their applicability in detecting the above heart-brain cross-talk events during long-term monitoring of ICP...
2018: Acta Neurochirurgica. Supplement
Guilin Chen, Jianlin Wu, Na Li, Mingquan Guo
Rhamnus davurica Pall. (R. davurica) has been used as a traditional medicine for many years in China and abroad and shown a wide spectrum of biological activities. Previously, we reported the phytochemical fingerprinting profile of R. davurica, its distinct anti-proliferative activities against HT-29 and SGC-7901 cell lines, and the topoisomerase I (Top I) ligands based on bio-affinity ultrafiltration and HPLC-MS (UF-HPLC-MS). Nevertheless, among the 32 peaks detected in the fingerprinting profile, the common bioactive constituents responsible for the anti-inflammatory and anti-proliferative activities in the extracts remain elusive...
February 24, 2018: Analytical and Bioanalytical Chemistry
Chiara Fania, Raffaele Pezzilli, Gianvico Melzi d'Eril, Cecilia Gelfi, Alessandra Barassi
BACKGROUND: There are a limited number of studies investigating the type of serum proteins capable of differentiating intraductal papillary mucinous neoplasms from benign or malignant diseases of the pancreas. AIMS: To select proteins able to differentiate intraductal papillary mucinous neoplasms from benign and malignant pancreatic disease using semiquantitative proteomics. METHODS: Serum samples were obtained from 74 patients (19 with type II intraductal papillary mucinous neoplasms, 8 with type I/III intraductal papillary mucinous neoplasms, 24 with chronic pancreatitis, 23 with pancreatic ductal adenocarcinomas) and 21 healthy subjects...
February 8, 2018: Digestive Diseases and Sciences
Riccardo Dal Bello, Joao Seco, Paulo Magalhaes Martins
PURPOSE: Range uncertainties limit the potential of charged particle therapy. In vivo and online range verification techniques could increase the confidence in the dose delivery distribution and lead to more conformal treatments. Prompt gamma imaging and prompt gamma spectroscopy (PGS) have been demonstrated for such purpose. The successful application of these techniques requires the development of a dedicated detector system optimized to the radiation energy ranges and the intensity...
February 7, 2018: Medical Physics
Julien Boccard, Serge Rudaz
Assessing potential alterations of metabolic pathways using large-scale approaches today plays a central role in clinical research. Because several thousands of mass features can be measured for each sample with separation techniques hyphenated to mass spectrometry (MS) detection, adapted strategies should be implemented to detect altered pathways and help to elucidate the mechanisms of pathologies. These procedures include peak detection, sample alignment, normalization, statistical analysis, and metabolite annotation...
2018: Methods in Molecular Biology
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