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"peak detection"

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https://www.readbyqxmd.com/read/29156685/whole-genome-and-transcriptome-analysis-reveal-maldi-tof-ms-and-sds-page-have-limited-performance-for-the-detection-of-the-key-outer-membrane-protein-in-carbapenem-resistant-klebsiella-pneumoniae-isolates
#1
Naina Adren Pinto, Roshan D'Souza, In Sik Hwang, Jongrak Choi, Yong Ha In, Hyung Soon Park, Choong-Min Ryu, Dongeun Yong, Kyungwon Lee
To detect the outer membrane protein (OMP), which plays a key role in carbapenem resistance, whole-genome and transcriptome analysis of the clinical carbapenem-resistant Klebsiella pneumoniae was carried out. The index strain lacked both OmpK35 and OmpK36, whereas the other strains lacked only OmpK35. After SDS-PAGE, the putative OMP bands were excised and identified as OmpA and OmpK36. MALDI-TOF MS showed peaks at ∼36 and ∼38 kDa that corresponded to OmpA and OmpK36, respectively. In all the strains except YMC2014/03/P345, the ∼38 kDa peaks were present...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104745/an-adaptive-and-time-efficient-ecg-r-peak-detection-algorithm
#2
Qin Qin, Jianqing Li, Yinggao Yue, Chengyu Liu
R-peak detection is crucial in electrocardiogram (ECG) signal analysis. This study proposed an adaptive and time-efficient R-peak detection algorithm for ECG processing. First, wavelet multiresolution analysis was applied to enhance the ECG signal representation. Then, ECG was mirrored to convert large negative R-peaks to positive ones. After that, local maximums were calculated by the first-order forward differential approach and were truncated by the amplitude and time interval thresholds to locate the R-peaks...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29103622/a-new-multi-stage-combined-kernel-filtering-approach-for-ecg-noise-removal
#3
Mazhar B Tayel, Ahmed S Eltrass, Abeer I Ammar
Electrocardiogram (ECG) signals are contaminated with different artifacts and noise sources which increase the difficulty in analyzing the ECG signals and obtaining accurate diagnosis of heart diseases. In this paper, a new multi-stage combined adaptive filtering design based on Kernel Recursive Least Squares Tracker (KRLST) and Kernel Recursive Least Squares with Approximate Linear Dependency (ALDKRLS) algorithms is proposed for removing artifacts and noise sources, while preserving the low frequency components and the tiny features of the ECG signal...
October 18, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29080869/-metabolomic-profiling-in-culture-media-of-day-5-human-embryos
#4
I M Zorina, C M Eldarov, S A Yarigina, N P Makarova, D Yu Trofimov, V Yu Smolnikova, E A Kalinina, M Yu Bobrov
The aim of this study was to determine the changes of metabolomic profiles in embryonic culture media (ECM) for the evaluation of quality and implantation potential of human embryos. ECM (n=163) were collected on day 5 before transfer or cryopreservation. Some embryos were used in preimplantation genetic screening for detection of aneuploidy karyotypes. Samples were subdivided into groups according to embryo morphological classification (by Gardner), genetic analysis and implantation data. ECM were extracted with methanol, precipitates were separated by centrifugation and metabolite production of individual embryo was analysed by LC-MS (the positive ion mode)...
October 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29065613/r-peak-detection-method-using-wavelet-transform-and-modified-shannon-energy-envelope
#5
Jeong-Seon Park, Sang-Woong Lee, Unsang Park
Rapid automatic detection of the fiducial points-namely, the P wave, QRS complex, and T wave-is necessary for early detection of cardiovascular diseases (CVDs). In this paper, we present an R peak detection method using the wavelet transform (WT) and a modified Shannon energy envelope (SEE) for rapid ECG analysis. The proposed WTSEE algorithm performs a wavelet transform to reduce the size and noise of ECG signals and creates SEE after first-order differentiation and amplitude normalization. Subsequently, the peak energy envelope (PEE) is extracted from the SEE...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29060794/modified-automatic-r-peak-detection-algorithm-for-patients-with-epilepsy-using-a-portable-electrocardiogram-recorder
#6
J Jeppesen, S Beniczky, A Fuglsang Frederiksen, P Sidenius, P Johansen
Earlier studies have shown that short term heart rate variability (HRV) analysis of ECG seems promising for detection of epileptic seizures. A precise and accurate automatic R-peak detection algorithm is a necessity in a real-time, continuous measurement of HRV, in a portable ECG device. We used the portable CE marked ePatch® heart monitor to record the ECG of 14 patients, who were enrolled in the videoEEG long term monitoring unit for clinical workup of epilepsy. Recordings of the first 7 patients were used as training set of data for the R-peak detection algorithm and the recordings of the last 7 patients (467...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060769/automatic-atrial-fibrillation-detection-a-novel-approach-using-discrete-wavelet-transform-and-heart-rate-variability
#7
Iben H Bruun, Semira M S Hissabu, Erik S Poulsen, Sadasivan Puthusserypady
Early detection of Atrial Fibrillation (AF) is crucial in order to prevent acute and chronic cardiac rhythm disorders. In this study, a novel method for robust automatic AF detection (AAFD) is proposed by combining atrial activity (AA) and heart rate variability (HRV), which could potentially be used as a screening tool for patients suspected to have AF. The method includes an automatic peak detection prior to the feature extraction, as well as a noise cancellation technique followed by a bagged tree classification...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060652/adaptive-fourier-decomposition-based-r-peak-detection-for-noisy-ecg-signals
#8
Ze Wang, Chi Man Wong, Feng Wan
An adaptive Fourier decomposition (AFD) based R-peak detection method is proposed for noisy ECG signals. Although lots of QRS detection methods have been proposed in literature, most detection methods require high signal quality. The proposed method extracts the R waves from the energy domain using the AFD and determines the R-peak locations based on the key decomposition parameters, achieving the denoising and the R-peak detection at the same time. Validated by clinical ECG signals in the MIT-BIH Arrhythmia Database, the proposed method shows better performance than the Pan-Tompkin (PT) algorithm in both situations of a native PT and the PT with a denoising process...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060491/non-contact-acquisition-of-respiration-and-heart-rates-using-doppler-radar-with-time-domain-peak-detection-algorithm
#9
Xiaofeng Yang, Guanghao Sun, Koichiro Ishibashi
The non-contact measurement of the respiration rate (RR) and heart rate (HR) using a Doppler radar has attracted more attention in the field of home healthcare monitoring, due to the extremely low burden on patients, unconsciousness and unconstraint. Most of the previous studies have performed the frequency-domain analysis of radar signals to detect the respiration and heartbeat frequency. However, these procedures required long period time (approximately 30 s) windows to obtain a high-resolution spectrum. In this study, we propose a time-domain peak detection algorithm for the fast acquisition of the RR and HR within a breathing cycle (approximately 5 s), including inhalation and exhalation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059822/a-novel-method-for-accurate-estimation-of-hrv-from-smartwatch-ppg-signals
#10
Tanmoy Bhowmik, Jishnu Dey, Vijay Narayan Tiwari
Photoplethysmography(PPG) as a non-invasive tool for monitoring various cardiovascular parameters, has become popular due to the ease of wearable integration and pervasive nature. Due to unobtrusive nature of sensor placement at wrist, smartwatches and wrist based fitness bands have gained popularity. However, any movement of the wrist along with frequent loose contacts significantly corrupts the PPG signal. Reliable peak detection from the corrupted PPG signal is essential for any further processing, as many physiological quantities such as heart rate variability (HRV) depends on the peak-to-peak distances in the PPG signal, known as the RR Series...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29048394/photoplethysmography-signal-analysis-for-optimal-region-of-interest-determination-in-video-imaging-on-a-built-in-smartphone-under-different-conditions
#11
Yunyoung Nam, Yun-Cheol Nam
Smartphones and tablets are widely used in medical fields, which can improve healthcare and reduce healthcare costs. Many medical applications for smartphones and tablets have already been developed and widely used by both health professionals and patients. Specifically, video recordings of fingertips made using a smartphone camera contain a pulsatile component caused by the cardiac pulse equivalent to that present in a photoplethysmographic signal. By performing peak detection on the pulsatile signal, it is possible to estimate a continuous heart rate and a respiratory rate...
October 19, 2017: Sensors
https://www.readbyqxmd.com/read/29047682/surface-recovery-algorithm-in-white-light-interferometry-based-on-combined-white-light-phase-shifting-and-fast-fourier-transform-algorithms
#12
Quangsang Vo, Fengzhou Fang, Xiaodong Zhang, Huimin Gao
Quality control of micro-nano structured and freeform surfaces is becoming increasingly important, which leads to challenging requirements in the measurement and characterization of rough and highly reflective surfaces. As an important measurement technique, white light scanning interferometry (WLSI) is a fast noncontact method to measure three-dimensional (3D) surface profiles. Nevertheless, the existing WLSI 3D surface reconstruction algorithms are prone to environmental vibrations and phase changes caused by reflections on the tested surface...
October 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29041225/photovoltaic-ge-sige-quantum-dot-mid-infrared-photodetector-enhanced-by-surface-plasmons
#13
A I Yakimov, V V Kirienko, A A Bloshkin, V A Armbrister, A V Dvurechenskii, J-M Hartmann
We report the fabrication and characterization of a multilayer Ge quantum dot detector grown on Si1-xGex virtual substrate (x = 0.18) for photovoltaic mid-wave infrared photodetection. Detector displays an over 100% photovoltaic response enhancement as compared to a conventional Ge/Si device due to smaller hole effective mass in the SiGe barriers. A further enhancement in sensitivity is achieved by excitation of surface plasmon polariton waves in a Ge/SiGe photodetector coupled with a two-dimensional plasmonic structure...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29037593/untargeted-analysis-of-chromatographic-data-for-green-and-fermented-rooibos-problem-with-size-effect-removal
#14
Jade Tobin, Jan Walach, Dalene de Beer, Paul J Williams, Peter Filzmoser, Beata Walczak
While analyzing chromatographic data, it is necessary to preprocess it properly before exploration and/or supervised modeling. To make chromatographic signals comparable, it is crucial to remove the scaling effect, caused by differences in overall sample concentrations. One of the efficient methods of signal scaling is Probabilistic Quotient Normalization (PQN) [1]. However, it can be applied only to data for which the majority of features do not vary systematically among the studied classes of signals. When studying the influence of the traditional "fermentation" (oxidation) process on the concentration of 56 individual peaks detected in rooibos plant material, this assumption is not fulfilled...
October 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29036359/profia-a-data-preprocessing-workflow-for-flow-injection-analysis-coupled-to-high-resolution-mass-spectrometry
#15
Alexis Delabrière, Ulli M Hohenester, Benoit Colsch, Christophe Junot, François Fenaille, Etienne A Thévenot
Motivation: Flow Injection Analysis coupled to High-Resolution Mass Spectrometry (FIA-HRMS) is a promising approach for high-throughput metabolomics. FIA-HRMS data, however, cannot be preprocessed with current software tools which rely on liquid chromatography separation, or handle low resolution data only. Results: We thus developed the proFIA package, which implements a suite of innovative algorithms to preprocess FIA-HRMS raw files, and generates the table of peak intensities...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29030275/metabolite-damage-and-repair-in-metabolic-engineering-design
#16
REVIEW
Jiayi Sun, James G Jeffryes, Christopher S Henry, Steven D Bruner, Andrew D Hanson
The necessarily sharp focus of metabolic engineering and metabolic synthetic biology on pathways and their fluxes has tended to divert attention from the damaging enzymatic and chemical side-reactions that pathway metabolites can undergo. Although historically overlooked and underappreciated, such metabolite damage reactions are now known to occur throughout metabolism and to generate (formerly enigmatic) peaks detected in metabolomics datasets. It is also now known that metabolite damage is often countered by dedicated repair enzymes that undo or prevent it...
October 10, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29018635/a-new-wavelet-based-ecg-delineator-for-the-evaluation-of-the-ventricular-innervation
#17
Matteo Cesari, Jesper Mehlsen, Anne-Birgitte Mehlsen, Helge Bjarup Dissing Sorensen
T-wave amplitude (TWA) has been proposed as a marker of the innervation of the myocardium. Until now, TWA has been calculated manually or with poor algorithms, thus making its use not efficient in a clinical environment. We introduce a new wavelet-based algorithm for the delineation QRS complexes and T-waves, and the automatic calculation of TWA. When validated in the MIT/BIH Arrhythmia database, the QRS detector achieved sensitivity and positive predictive value of 99.84% and 99.87%, respectively. The algorithm was validated also on the QT database and it achieved sensitivity of 99...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28956859/an-efficient-hardware-circuit-for-spike-sorting-based-on-competitive-learning-networks
#18
Huan-Yuan Chen, Chih-Chang Chen, Wen-Jyi Hwang
This study aims to present an effective VLSI circuit for multi-channel spike sorting. The circuit supports the spike detection, feature extraction and classification operations. The detection circuit is implemented in accordance with the nonlinear energy operator algorithm. Both the peak detection and area computation operations are adopted for the realization of the hardware architecture for feature extraction. The resulting feature vectors are classified by a circuit for competitive learning (CL) neural networks...
September 28, 2017: Sensors
https://www.readbyqxmd.com/read/28952947/miniaturized-impedance-flow-cytometer-design-rules-and-integrated-readout
#19
Marco Carminati, Giorgio Ferrari, Michael D Vahey, Joel Voldman, Marco Sampietro
A dual-channel credit-card-sized impedance cell counter featuring a throughput of 2000 cell/s and detection of single yeast cells (5 μm) with a signal-to-noise ratio of 20 dB is presented. Its compactness is achieved by a CMOS ASIC combining a lock-in impedance demodulator with an oversampling 20-bit ΣΔ ADC and real-time peak detection embedded in field-programmable gate array. The module is coupled to a dielectrophoretic cell-sorting microfluidic device, offering compact and label-free electrical readout that replaces the need for a fluorescence microscope and, thus, is suitable for point-of-care diagnostics...
September 22, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28942951/the-algorithmic-performance-of-j-tpeak-for-drug-safety-clinical-trial
#20
Simon C Chien, Richard E Gregg
INTRODUCTION: The interval from J-point to T-wave peak (JTp) in ECG is a new biomarker able to identify drugs that prolong the QT interval but have different ion channel effects. If JTp is not prolonged, the prolonged QT may be associated with multi ion channel block that may have low torsade de pointes risk. From the automatic ECG measurement perspective, accurate and repeatable measurement of JTp involves different challenges than QT. We evaluated algorithm performance and JTp challenges using the Philips DXL diagnostic 12/16/18-lead algorithm...
August 15, 2017: Journal of Electrocardiology
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