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https://www.readbyqxmd.com/read/28433624/temporal-slice-registration-and-robust-diffusion-tensor-reconstruction-for-improved-fetal-brain-structural-connectivity-analysis
#1
Bahram Marami, Seyed Sadegh Mohseni Salehi, Onur Afacan, Benoit Scherrer, Caitlin K Rollins, Edward Yang, Judy A Estroff, Simon K Warfield, Ali Gholipour
Diffusion weighted magnetic resonance imaging, or DWI, is one of the most promising tools for the analysis of neural microstructure and the structural connectome of the human brain. The application of DWI to map early development of the human connectome in-utero, however, is challenged by intermittent fetal and maternal motion that disrupts the spatial correspondence of data acquired in the relatively long DWI acquisitions. Fetuses move continuously during DWI scans. Reliable and accurate analysis of the fetal brain structural connectome requires careful compensation of motion effects and robust reconstruction to avoid introducing bias based on the degree of fetal motion...
April 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28433388/magnetic-resonance-and-diffusion-tensor-imaging-analyses-indicate-heterogeneous-strains-along-human-medial-gastrocnemius-fascicles-caused-by-submaximal-plantar-flexion-activity
#2
Agah Karakuzu, Uluç Pamuk, Cengizhan Ozturk, Burak Acar, Can A Yucesoy
Sarcomere length changes are central to force production and excursion of skeletal muscle. Previous modeling indicates non-uniformity of that if mechanical interaction of muscle with its surrounding muscular and connective tissues is taken into account. Hence, quantifying length changes along the fascicles of activated human muscle in vivo is crucial, but this is lacking due to technical complexities. Combining magnetic resonance imaging deformation analyses and diffusion tensor imaging tractography, the aim was to test the hypothesis that submaximal plantar flexion activity at 15% MVC causes heterogeneous length changes along the fascicles of human medial gastrocnemius (GM) muscle...
April 9, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28429381/the-structural-connectome-of-children-with-traumatic-brain-injury
#3
Marsh Königs, L W Ernest van Heurn, Roel Bakx, R Jeroen Vermeulen, J Carel Goslings, Bwee Tien Poll-The, Marleen van der Wees, Coriene E Catsman-Berrevoets, Jaap Oosterlaan, Petra J W Pouwels
This study aimed to investigate the impact of mild to severe pediatric TBI on the structural connectome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mild(RF+) , n = 20) or moderate/severe TBI (n = 16) at 2.8 years post-injury. Probabilistic tractography on diffusion tensor imaging data was used in combination with graph theory to study structural connectivity. Functional outcome was measured using neurocognitive tests and parent and teacher questionnaires for behavioral functioning...
April 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28425348/integration-of-functional-mri-and-white-matter-tractography-in-cyberknife-radiosurgery
#4
Lu Sun, Baolin Qu, Jinyuan Wang, Zhongjian Ju, Zizhong Zhang, Zhiqiang Cui, Yang Jack, Zhipei Ling, Xinguang Yu, Longsheng Pan
PURPOSE: To investigate the efficacy of the integration of functional magnetic resonance imaging and diffusion-tensor imaging tractography data into CyberKnife radiosurgery for intracranial tumor management. MATERIALS AND METHODS: Functional neuroimaging, anatomical magnetic resonance imaging, and computed tomography images of patients with brain lesions in critical areas were acquired before radiosurgery. The acquired data sets were coregistered using the MIM image fusion software module and then were imported into the CyberKnife Robotic Radiosurgery System (Multiplan 4...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28422895/diffusion-tensor-tractography-for-detection-of-concomitant-traumatic-brain-injury-in-patients-with-traumatic-spinal-cord-injury
#5
Sung Ho Jang, Sang Ho Ahn, Yun Woo Cho, Ji Woon Lim, Ik Tae Cho
OBJECTIVES: We investigated concomitant traumatic brain injury in patients with traumatic spinal cord injury (TSCI) who had head trauma history, using diffusion tensor tractography (DTT). DESIGN: Retrospective survey. PARTICIPANTS: We recruited 14 consecutive patients with TSCI and coexisting head trauma history at the time of TSCI and 30 control subjects. METHODS: The corticospinal tract (CST), corticoreticulospinal tract (CRT), cingulum, and fornix were reconstructed using DTT, and DTT parameters (fractional anisotropy and fiber volume) and configuration were estimated...
January 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28422761/topological-length-of-white-matter-connections-predicts-their-rate-of-atrophy-in-premanifest-huntington-s-disease
#6
Peter McColgan, Kiran K Seunarine, Sarah Gregory, Adeel Razi, Marina Papoutsi, Jeffrey D Long, James A Mills, Eileanoir Johnson, Alexandra Durr, Raymund A C Roos, Blair R Leavitt, Julie C Stout, Rachael I Scahill, Chris A Clark, Geraint Rees, Sarah J Tabrizi, The Track-On Hd Investigators
We lack a mechanistic explanation for the stereotyped pattern of white matter loss seen in Huntington's disease (HD). While the earliest white matter changes are seen around the striatum, within the corpus callosum, and in the posterior white matter tracts, the order in which these changes occur and why these white matter connections are specifically vulnerable is unclear. Here, we use diffusion tractography in a longitudinal cohort of individuals yet to develop clinical symptoms of HD to identify a hierarchy of vulnerability, where the topological length of white matter connections between a brain area and its neighbors predicts the rate of atrophy over 24 months...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28421658/transcriptional-signatures-of-connectomic-subregions-of-the-human-striatum
#7
Linden Parkes, Ben Fulcher, Murat Yücel, Alex Fornito
Functionally distinct regions of the brain are thought to possess a characteristic connectional fingerprint - a profile of incoming and outgoing connections that defines the function of that area. This observation has motivated efforts to subdivide brain areas using their connectivity patterns. However, it remains unclear whether these connectomically-defined subregions can be distinguished at the molecular level. Here, we combine high-resolution diffusion-weighted magnetic resonance imaging with transcriptomic data to show that connectomically-defined subregions of the striatum carry distinct transcriptional signatures...
April 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28421284/oropharyngeal-dysphagia-in-secondary-normal-pressure-hydrocephalus-due-to-corticobulbar-tract-compression-cases-series-and-review-of-literature
#8
Kwang Wook Jo, Youngkook Kim, Geun-Young Park, Ik Seong Park, Yongjun Jang, Sohn Dong Gyun, Sun Im
The association and mechanism involved in swallowing disturbance and normal pressure hydrocephalus (NPH) needs to be established. We report a case report where a patient who showed progressive swallowing dysfunction was diagnosed with secondary NPH. Tractography analysis showed corticobulbar tract compression by ventricular dilation. Drainage operation led to the recovery of tract volume with an improvement of swallowing function. We also report ten case series in which secondary NPH was associated with a swallowing disturbance...
April 19, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28419638/a-diffusion-tensor-imaging-tractography-study-in-bipolar-disorder-patients-compared-to-first-degree-relatives-and-healthy-controls
#9
Ananya Mahapatra, Sudhir Kumar Khandelwal, Pratap Sharan, Ajay Garg, N K Mishra
AIM: To compare white matter structural changes in specific tracts by diffusion tensor imaging (DTI) tractography in patients of bipolar disorder I, non-ill first degree relatives of the patients, and healthy controls. METHODS: In a cross sectional study, we studied right-handed subjects consisting of 16 euthymic bipolar disorder I patients, 15 first degree relatives and 15 healthy controls. The anterior thalamic radiation, uncinate fasciculus, corpus callosum, and cingulum bundle were reconstructed by DTI tractography...
April 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28419058/a-method-for-u-fiber-quantification-from-7%C3%A2-t-diffusion-weighted-mri-data-tested-in-patients-with-nonlesional-focal-epilepsy
#10
Rafael O'Halloran, Rebecca Feldman, Lara Marcuse, Madeline Fields, Bradley Delman, Sophia Frangou, Priti Balchandani
In this methods development, we present an ultra-high-field, diffusion-weighted MRI method to quantitatively assess u-fibers and use it to compare u-fiber counts in nonlesional epilepsy patients with controls. Emerging evidence implicates white matter abnormalities in nonlesional epilepsy, including the short-range, cortical-cortical connections, or u-fibers. Eight patients with nonlesional epilepsy and eight demographically matched controls underwent 7 T MRI consisting of a T1-weighted sequence (0.7 mm isotropic resolution) and high-angular-resolved diffusion-weighted MRI (1...
April 17, 2017: Neuroreport
https://www.readbyqxmd.com/read/28413699/white-matter-connections-of-the-inferior-parietal-lobule-a-study-of-surgical-anatomy
#11
Joshua D Burks, Lillian B Boettcher, Andrew K Conner, Chad A Glenn, Phillip A Bonney, Cordell M Baker, Robert G Briggs, Nathan A Pittman, Daniel L O'Donoghue, Dee H Wu, Michael E Sughrue
INTRODUCTION: Interest in the function of the inferior parietal lobule (IPL) has resulted in increased understanding of its involvement in visuospatial and cognitive functioning, and its role in semantic networks. A basic understanding of the nuanced white-matter anatomy in this region may be useful in improving outcomes when operating in this region of the brain. We sought to derive the surgical relationship between the IPL and underlying major white-matter bundles by characterizing macroscopic connectivity...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28411159/in-vivo-visualization-of-connections-among-revised-papez-circuit-hubs-using-full-q-space-diffusion-spectrum-imaging-tractography
#12
Peng-Hu Wei, Zhi-Qi Mao, Fei Cong, Fang-Cheng Yeh, Bo Wang, Zhi-Pei Ling, Shu-Li Liang, Lin Chen, Xin-Guang Yu
Structural connections among the hubs of the revised Papez circuit remain to be elucidated in the human brain. As the original Papez circuit failed to explain functional imaging findings, a more detailed investigation is needed to delineate connections among the circuit's key hubs. Here we acquired diffusion spectrum imaging (DSI) from eight normal subjects and used data from the Human Connectome Project (HCP) to elucidate connections among hubs in the retrosplenial gyrus, hippocampus, mammillary bodies, and anterior thalamic nuclei...
April 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/28406325/akinetic-mutism-in-a-patient-with-mild-traumatic-brain-injury-a-diffusion-tensor-tractography-study
#13
Sung Ho Jang, Hyeok Gyu Kwon
OBJECTIVES: Akinetic mutism (AM) is characterized by a complete absence of spontaneous behaviour and speech. We report on a patient with AM associated with injury of the prefronto-caudate tract and prefronto-thalamic tract following mild traumatic brain injury (TBI), diffusion tensor tractography (DTT). CASE PRESENTATION: A 20-year-old man suffered from TBI resulting from a pedestrian car accident. Following the TBI, he developed abulia (decreased activity and speech) that worsened over approximately a year...
April 13, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28402130/hallway-conversations-in-physicsmri-tractography-mapping-white-matter-tracts-in-the-brain
#14
John Donnellan, Nicholas Shkumat, Manohar Shroff, Prakash Muthusami
No abstract text is available yet for this article.
April 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28401047/neuroimaging-studies-of-cognitive-remediation-in-schizophrenia-a-systematic-and-critical-review
#15
Rafael Penadés, Alexandre González-Rodríguez, Rosa Catalán, Bàrbara Segura, Miquel Bernardo, Carme Junqué
AIM: To examine the effects of cognitive remediation therapies on brain functioning through neuroimaging procedures in patients with schizophrenia. METHODS: A systematic, computerised literature search was conducted in the PubMed/Medline and PsychInfo databases. The search was performed through February 2016 without any restrictions on language or publication date. The search was performed using the following search terms: [("cogniti*" and "remediation" or "training" or "enhancement") and ("fMRI" or "MRI" or "PET" or "SPECT") and (schizophrenia or schiz*)]...
March 22, 2017: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28397839/a-connectomic-approach-for-subcallosal-cingulate-deep-brain-stimulation-surgery-prospective-targeting-in-treatment-resistant-depression
#16
P Riva-Posse, K S Choi, P E Holtzheimer, A L Crowell, S J Garlow, J K Rajendra, C C McIntyre, R E Gross, H S Mayberg
Target identification and contact selection are known contributors to variability in efficacy across different clinical indications of deep brain stimulation surgery. A retrospective analysis of responders to subcallosal cingulate deep brain stimulation (SCC DBS) for depression demonstrated the common impact of the electrical stimulation on a stereotypic connectome of converging white matter bundles (forceps minor, uncinate fasciculus, cingulum and fronto-striatal fibers). To test the utility of a prospective connectomic approach for SCC DBS surgery, this pilot study used the four-bundle tractography 'connectome blueprint' to plan surgical targeting in 11 participants with treatment-resistant depression...
April 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28395166/semi-local-tractography-strategies-using-neighborhood-information
#17
Helen Schomburg, Thorsten Hohage
Fiber tractography based on Diffusion MRI measurements is a valuable tool for the detection and visual representation of neural pathways in vivo. We present a novel fiber orientation distribution function (ODF) based streamline tractography approach which incorporates information of neighboring regions derived from a Bayesian model. In each iteration step, the proposed algorithm defines a set of candidate fiber fragments continuing the already tracked path and assigns an a-posteriori probability. We compute the posterior as the normalized product of a likelihood function based on the given ODF-field and a prior distribution representing anatomical plausibility of a candidate fiber fragment with respect to tract curvature derived from the previously tracked fiber path by an extrapolation strategy...
March 24, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28391647/probabilistic-versus-deterministic-fiber-tracking-and-the-influence-of-different-seed-regions-to-delineate-cerebellar-thalamic-fibers-in-deep-brain-stimulation
#18
Juergen R Schlaier, Anton L Beer, Rupert Faltermeier, Claudia Fellner, Kathrin Steib, Max Lange, Mark W Greenlee, Alexander T Brawanski, Judith M Anthofer
This study compared tractography approaches for identifying cerebellar-thalamic fiber bundles relevant for planning target sites for deep brain stimulation (DBS). In particular, probabilistic and deterministic tracking of the dentate-rubro-thalamic tract (DRTT) and differences between the spatial courses of the DRTT and the cerebello-thalamo-cortical (CTC) tract were compared. Six patients with movement disorders were examined by magnetic resonance imaging (MRI) including two sets of diffusion-weighted images (12 and 64 directions)...
April 9, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28390437/brain-structural-investigation-and-hippocampal-tractography-in-medication-overuse-headache-a-native-space-analysis
#19
M Meyer, G Di Scala, M Edde, B Dilharreguy, F Radat, M Allard, S Chanraud
BACKGROUND: Spatial normalization of brain images, a prerequisite for voxel based morphometry analysis, may account for the large variability of the volumetric data in medication overuse headache (MOH); possibly because this disease concerns patients differing on both sex and age, and hence with different brain size and shape. METHODS: The present study aimed at providing a subject-based analysis of macrostructure using a native space volumes segmentation (Freesurfer), and microstructure using a region of interest (ROI: i...
April 8, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28389885/anatomical-evaluation-of-lumbar-nerves-using-diffusion-tensor-imaging-and-implications-of-lateral-decubitus-for-lateral-transpsoas-approach
#20
Yasuhiro Oikawa, Yawara Eguchi, Atsuya Watanabe, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Yoshihiro Sakuma, Go Kubota, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Kazuki Fujimoto, Masao Koda, Takeo Furuya, Koji Matsumoto, Yoshitada Masuda, Yasuchika Aoki, Kazuhisa Takahashi, Seiji Ohtori
PURPOSE: Recently, lateral interbody fusion (LIF) has become more prevalent, and evaluation of lumbar nerves has taken on new importance. We report on the assessment of anatomical relationships between lumbar nerves and vertebral bodies using diffusion tensor imaging (DTI). METHODS: Fifty patients with degenerative lumbar disease and ten healthy subjects underwent DTI. In patients with lumbar degenerative disease, we studied nerve courses with patients in the supine positions and with hips flexed...
April 7, 2017: European Spine Journal
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