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Bruce Steinberg, Kenneth Blum, Thomas McLaughlin, Joel Lubar, Marcelo Febo, Eric R Braverman, Rajendra D Badgaiyan
Attention Deficit-Hyperactivity Disorder (ADHD) often continues into adulthood. Recent neuroimaging studies found lowered baseline dopamine tone in the brains of affected individuals that may place them at risk for Substance Use Disorder (SUD). This is an observational case study of the potential for novel management of Adult ADHD with a non-addictive glutaminergic-dopaminergic optimization complex KB200z. Low-resolution electromagnetic tomography (LORETA) was used to evaluate the effects of KB220z on a 72-year-old male with ADHD, at baseline and one hour following administration...
2016: Open Journal of Clinical & Medical Case Reports
Edward Justin Modestino, Kenneth Blum, Marlene Oscar-Berman, Mark S Gold, Drake D Duane, Sarah G S Sultan, Sanford H Auerbach
We theorise that in some cases Attention Deficit Hyperactivity Disorder (ADHD) predisposes to narcolepsy and hypersomnia, and that there may be a shared pathophysiology with various addictions [Reward Deficiency Syndrome (RDS)]. Reticence to acknowledge such connections may be due to a narrow nosological framework. Additionally, we theorise that the development of narcolepsy on a baseline of ADHD/RDS leads to an additional assault on the dopaminergic reward system in such individuals. In this study, we propose to test these hypotheses by using a combination of broad genetic screening, and neuroimaging with and without pharmacological intervention, in those with pure ADHD, pure narcolepsy, and the combined ADHD-narcolepsy phenotype...
2015: Journal of Reward Deficiency Syndrome
Thomas McLaughlin, Kenneth Blum, Marlene Oscar-Berman, Marcelo Febo, Gozde Agan, James L Fratantonio, Thomas Simpatico, Mark S Gold
BACKGROUND: Lucid dreams are frequently pleasant and training techniques have been developed to teach dreamers to induce them. In addition, the induction of lucid dreams has also been used as a way to ameliorate nightmares. On the other hand, lucid dreams may be associated with psychiatric conditions, including Post-Traumatic Stress Disorder (PTSD) and Reward Deficiency Syndrome-associated diagnoses. In the latter conditions, lucid dreams can assume an unpleasant and frequently terrifying character...
June 2015: Journal of Behavioral Addictions
Thomas McLaughlin, Kenneth Blum, Marlene Oscar-Berman, Marcelo Febo, Zsolt Demetrovics, Gozde Agan, James Fratantonio, Mark S Gold
BACKGROUND: Lucid Dreams are a form of dream life, during which the dreamer may be aware that he/she is dreaming, can stop/re-start the dreams, depending on the pleasantness or unpleasant nature of the dream, and experiences the dream as if he/she were fully awake. Depending on their content, they may be pleasant, un-pleasant or terrifying, at least in the context of patients, who also exhibit characteristics of Reward Deficiency Syndrome (RDS) and Posttraumatic Stress Disorder (PTSD)...
2015: Journal of Reward Deficiency Syndrome
Kenneth Blum, Yijun Liu, Wei Wang, Yarong Wang, Yi Zhang, Marlene Oscar-Berman, Andrew Smolen, Marcelo Febo, David Han, Thomas Simpatico, Frans J Cronjé, Zsolt Demetrovics, Mark S Gold
Recently, Willuhn et al. reported that cocaine use and even non-substance-related addictive behavior increases as dopaminergic function is reduced. Chronic cocaine exposure has been associated with decreases in D2/D3 receptors and was also associated with lower activation of cues in occipital cortex and cerebellum, in a recent PET study by Volkow's et al. Therefore, treatment strategies, like dopamine agonist therapy, that might conserve dopamine function may be an interesting approach to relapse prevention in psychoactive drug and behavioral addictions...
March 2015: Postgraduate Medicine
Kenneth Blum, Marlene Oscar-Berman, John Femino, Roger L Waite, Lisa Benya, John Giordano, Joan Borsten, William B Downs, Eric R Braverman, Raquel Loehmann, Kristina Dushaj, David Han, Thomas Simpatico, Mary Hauser, Debmalya Barh, Thomas McLaughlin
BACKGROUND: While numerous studies support the efficacy of methadone and buprenorphine for the stabilization and maintenance of opioid dependence, clinically significant opioid withdrawal symptoms occur upon tapering and cessation of dosage. METHODS: We present a case study of a 35 year old Caucasian female (Krissie) who was prescribed increasing dosages of prescription opioids after carpel tunnel surgery secondary to chronic pain from reflex sympathetic dystrophy and fibromyalgia...
April 23, 2013: Journal of Addiction Research & Therapy
Thomas J H Chen, Kenneth Blum, Amanda L C Chen, Abdalla Bowirrat, William B Downs, Margret A Madigan, Roger L Waite, John A Bailey, Mallory Kerner, Swetha Yeldandi, Neil Majmundar, John Giordano, Siohban Morse, David Miller, Frank Fornari, Eric R Braverman
This document presents evidence supporting the role of the KB220/KB220Z neuroadaptagens consisting of amino-acid neurotransmitter precursors and enkephalinase-catecholamine-methyl-transferase (COMT) inhibition therapy called Neuroadaptagen Amino Acid Therapy (NAAT) in brain reward function. It is becoming increasingly clear that this novel formulation is the first neuroadaptagen known to activate the brain reward circuitry. Ongoing research repeatedly confirms the numerous clinical effects that ultimately result in significant benefits for victims having genetic antecedents for all addictive, compulsive and impulsive behaviors...
April 2011: Journal of Psychoactive Drugs
Kenneth Blum, Thomas J H Chen, Siobhan Morse, John Giordano, Amanda Lih Chaun Chen, James Thompson, Cameron Allen, Andrew Smolen, Joel Lubar, Eric Stice, B William Downs, Roger L Waite, Margaret A Madigan, Mallory Kerner, Frank Fornari, Eric R Braverman
BACKGROUND: It is well established that in both food- and drug-addicted individuals there is "dopamine resistance" associated with the DRD2 gene A1 allele. Based on earlier studies, evidence is emerging wherein the potential of utilizing a natural, nonaddicting, safe, putative D2 agonist may play a significant role in the recovery of individuals with reward deficiency syndrome, including those addicted to psychoactive chemicals. FINDINGS: Positive outcomes demonstrated by quantitative electroencephalographic (qEEG) imaging in a randomized, triple-blind, placebo-controlled, crossover study involving oral Synaptose Complex KB220Z™ showed an increase of alpha waves and low beta wave activity in the parietal brain region...
November 2010: Postgraduate Medicine
David K Miller, Abdalla Bowirrat, Matthew Manka, Merlene Miller, Stanley Stokes, Debra Manka, Cameron Allen, Charles Gant, B William Downs, Andrew Smolen, Emily Stevens, Swetha Yeldandi, Kenneth Blum
It is well established that in both food- and drug-addicted individuals, there is dopamine resistance due to an association with the DRD2 gene A1 allele. Evidence is emerging whereby the potential of utilizing a natural, nonaddicting, safe, putative D2 agonist may find its place in recovery from reward deficiency syndrome (RDS) in patients addicted to psychoactive chemicals. Utilizing quantitative electroencephalography (qEEG) as an imaging tool, we show the impact of Synaptamine Complex Variant KB220™ as a putative activator of the mesolimbic system...
November 2010: Postgraduate Medicine
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