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Holistic medicine

Paula R Pullen, William S Seffens, Walter R Thompson
Background: Complementary and alternative medicine is a rapidly growing area of biomedical inquiry. Yoga has emerged in the forefront of holistic medical care due to its long history of linking physical, mental, and spiritual well-being. Research in yoga therapy (YT) has associated improved cardiovascular and quality of life (QoL) outcomes for the special needs of heart failure (HF) patients. Aim: The aim of this study is to review yoga intervention studies on HF patients, discuss proposed mechanisms, and examine yoga's effect on physiological systems that have potential benefits for HF patients...
May 2018: International Journal of Yoga
G N Christodoulou, J E Mezzich, C R Cloninger, N Christodoulou, E Villar, J Appleyard, M Botbol
This article defines the scope of Person-Centered Medicine, traces its roots in ancient conceptions, explains the reasons for the revival of this perspective in our times, and highlights the contribution of the International College of Person-Centered Medicine (ICPCM) in the promotion of the personcentered perspective in health and disease. The value of communication is underlined with reference to both diagnosis and treatment. The concept of Health is considered historically and the inclusiveness, holistic vista and positive health orientation of the WHO definition of Health (1948) is underlined...
January 2018: Psychiatrikē, Psychiatriki
Juliet T Jarrell, Li Gao, David S Cohen, Xudong Huang
Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ru Yan, Ying Yang, Yijia Chen
The modernization and internationalization of Chinese medicines (CMs) are hampered by increasing concerns on the safety and the efficacy. Pharmacokinetic (PK) study is indispensable to establish concentration-activity/toxicity relationship and facilitate target identification and new drug discovery from CMs. To cope with tremendous challenges rooted from chemical complexity of CMs, the classic PK strategies have evolved rapidly from PK study focusing on marker/main drug components to PK-PD correlation study adopting metabolomics approaches to characterize associations between disposition of global drug-related components and host metabolic network shifts...
2018: Chinese Medicine
Mengfei Ho, Amel Mettouchi, Brenda A Wilson, Emmanuel Lemichez
Alterations of the cellular proteome over time due to spontaneous or toxin-mediated enzymatic deamidation of glutamine (Gln) and asparagine (Asn) residues contribute to bacterial infection and might represent a source of aging-related diseases. Here, we put into perspective what is known about the mode of action of the CNF1 toxin from pathogenic E. coli, a paradigm of bacterial deamidases that activate Rho GTPases, to illustrate the importance of determining whether exposure to these factors are risk factors in the etiology age-related diseases, such as cancer...
May 3, 2018: Pathogens and Disease
Kalliopi Trachana, Rhishikesh Bargaje, Gustavo Glusman, Nathan D Price, Sui Huang, Leroy E Hood
Systems medicine is a holistic approach to deciphering the complexity of human physiology in health and disease. In essence, a living body is constituted of networks of dynamically interacting units (molecules, cells, organs, etc) that underlie its collective functions. Declining resilience because of aging and other chronic environmental exposures drives the system to transition from a health state to a disease state; these transitions, triggered by acute perturbations or chronic disturbance, manifest as qualitative shifts in the interactions and dynamics of the disease-perturbed networks...
April 27, 2018: Circulation Research
A Yeong Lee, Won Park, Tae-Wook Kang, Min Ho Cha, Jin Mi Chun
ETHNOPHARMACOLOGICAL RELEVANCE: Yijin-Tang (YJT) is a traditional prescription for the treatment of hyperlipidaemia, atherosclerosis and other ailments related to dampness phlegm, a typical pathological symptom of abnormal body fluid metabolism in Traditional Korean Medicine. However, a holistic network pharmacology approach to understanding the therapeutic mechanisms underlying hyperlipidaemia and atherosclerosis has not been pursued. AIM OF THE STUDY: To examine the network pharmacological potential effects of YJT on hyperlipidaemia and atherosclerosis, we analysed components, performed target prediction and network analysis, and investigated interacting pathways using a network pharmacology approach...
July 15, 2018: Journal of Ethnopharmacology
Mike R Sather, Sherry Parsons, Kathy D Boardman, Stuart R Warren, Anne Davis-Karim, Kevin Griffin, Jane A Betterton, Mark S Jones, Stanley H Johnson, Julia E Vertrees, Jan H Hickey, Thelma P Salazar, Grant D Huang
This paper presents the quality journey taken by a Federal organization over more than 20 years. These efforts have resulted in the implementation of a Total Integrated Performance Excellence System (TIPES) that combines key principles and practices of established quality systems. The Center has progressively integrated quality system frameworks including the Malcom Baldrige National Quality Award (MBNQA) Framework and Criteria for Performance Excellence, ISO 9001, and the Organizational Project Management Maturity Model (OPM3), as well as supplemental quality systems of ISO 15378 (packaging for medicinal products) and ISO 21500 (guide to project management) to systematically improve all areas of operations...
March 2018: Contemporary Clinical Trials Communications
Olivier Lesieur
In its legal sense, the term 'consent' finalises an agreement between two parties. When the care relationship is a long-term process, consent becomes a dynamic interaction between patient and caregivers, resulting in a fragile compromise which is continuously being brought into question by the unpredictable nature of the illness. Based on a holistic approach to the concept of autonomy, the decision-making process should take into account both the rationality of the deliberation and the individual's specific preferences...
April 2018: Soins; la Revue de Référence Infirmière
Ping Xin, Hai-Xue Kuang, Xiao-Liang Li, Yu Wang, Ben-Mei Zhang, He Bu, Zhi-Bin Wang, Yong-Hai Meng, Yan-Hong Wang, Qiu-Hong Wang
There is no doubt that the traditional Chinese medicine(TCM) is effective, practical and scientific after it was used for thousands of years. However, the mechanisms of action of many TCM are still unclear because of their multi-component, multi-target and multi-level features, which hinder the modernization and internationalization of the TCM. Proteomics is to analyze the composition and activity of intracellular proteins which are changing dynamically from a holistic perspective. It is consistent with the holistic and dynamic views of the TCM and brings about the hope of clarifying the mechanism of action of the TCM...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Matthew T McKenna, Jared A Weis, Amy Brock, Vito Quaranta, Thomas E Yankeelov
Medical oncology is in need of a mathematical modeling toolkit that can leverage clinically-available measurements to optimize treatment selection and schedules for patients. Just as the therapeutic choice has been optimized to match tumor genetics, the delivery of those therapeutics should be optimized based on patient-specific pharmacokinetic/pharmacodynamic properties. Under the current approach to treatment response planning and assessment, there does not exist an efficient method to consolidate biomarker changes into a holistic understanding of treatment response...
April 16, 2018: Translational Oncology
William E Rosa, Stephanie Hope, Marianne Matzo
The fields of palliative and holistic nursing both maintain a commitment to the care of the whole person, including a focus on spiritual care. Advanced serious illness may pose a plethora of challenges to patients seeking to create meaning and purpose in their lives. The purpose of this article is to introduce scholarly dialogue on the integration of entheogens, medicines that engender an experience of the sacred, into the spiritual and holistic care of patients experiencing advanced serious illness. A brief history of the global use of entheogens as well as a case study are provided...
April 1, 2018: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
Lihua Zuo, Lin Zhou, Tanye Xu, Zhuolun Li, Liwei Liu, Yingying Shi, Jian Kang, Guanmin Gao, Shuzhang Du, Zhi Sun, Xiaojian Zhang
Xuebijing (XBJ) injection is an ethnomedicinal formula that has been widely used in the therapy of sepsis in China. However, the underlying theraputic mechanisms remain uninvestigated. In this research, a metabolomic method based on UHPLC-Q-Orbitrap HRMS was applied to make a holistic evaluation of XBJ on septic rats which were induced by the classical cecal ligation and puncture (CLP) operation. The plasma metabolic changes were profiled and evaluated by multivariate analytical (MVA) methods. In the results, a total of 41 differential metabolites were identified between CLP-operated group and sham-operated group, which were mainly involved in amino acid metabolism and lipid metabolism...
2018: Frontiers in Pharmacology
Ying Chen, Jinfang Huang, Zhao Qin Yeap, Xue Zhang, Shuisheng Wu, Chiew Hoong Ng, Mun Fei Yam
Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is a precious traditional Chinese medicinal herb and has been perennially used to treat various illness. However, there were unethical sellers who adulterated wild A. roxburghii with tissue cultured and cultivated ones. Therefore, there is an urgent need for an effective authentication method to differentiate between these different types of A. roxburghii. In this research, the infrared spectroscopic tri-step identification approach including Fourier transform infrared spectroscopy (FT-IR), Second derivative infrared spectra (SD-IR) and two-dimensional correlation infrared spectra (2D-IR) was used to develop a simple and rapid method to discriminate between wild, cultivated and tissue cultivated A...
March 24, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Mushtaq Ahmad, Khafsa Malik, Akash Tariq, Guolin Zhang, Ghulam Yaseen, Neelam Rashid, Shazia Sultana, Muhammad Zafar, Kifayat Ullah, Muhammad Pukhtoon Zada Khan
ETHNOPHARMACOLOGICAL RELEVANCE: Himalayan paeony (Paeonia emodi Royle.) is an important species used to treat various diseases. This study aimed to compile the detailed traditional medicinal uses, phytochemistry, pharmacology and toxicological investigations on P. emodi. This study also highlights taxonomic validity, quality of experimental designs and shortcomings in previously reported information on Himalayan paeony. METHODS: The data was extracted from unpublished theses (Pakistan, China, India and Nepal), and different published research articles confined to pharmacology, phytochemistry and antimicrobial activities using different databases through specific keywords...
April 3, 2018: Journal of Ethnopharmacology
Ericka L Fink, R Scott Watson
No abstract text is available yet for this article.
April 2018: Pediatric Critical Care Medicine
Reginald F Baugh
Ignoring the diverse and rich cultures and histories of Africa and the African diaspora by applying the term African American to anyone of sub-Saharan African ancestry in medical school admissions does a disservice to applicants, medical schools, and the communities they serve. To determine how applicants can contribute to a diverse educational environment, admissions decisions must go beyond racial and ethnic self-reporting and recognize the diversity applicants bring to their medical school. Using a holistic approach, institutions can fairly evaluate applicants and strategically fill their incoming classes...
April 3, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Noel R Eatough
No abstract text is available yet for this article.
April 2, 2018: Medical Journal of Australia
Nam-Hoon Kim, Murukarthick Jayakodi, Sang-Choon Lee, Beom-Soon Choi, Woojong Jang, Junki Lee, Hyun Hee Kim, Nomar Espinosa Waminal, Meiyappan Lakshmanan, Binh Van Nguyen, Yun Sun Lee, Hyun-Seung Park, Hyun Jo Koo, Jee Young Park, Sampath Perumal, Ho Jun Joh, Hana Lee, Jinkyung Kim, In Seo Kim, Kyunghee Kim, Lokanand Koduru, Kyo Bin Kang, Sang Hyun Sung, Yeisoo Yu, Daniel S Park, Doil Choi, Eunyoung Seo, Seungill Kim, Young-Chang Kim, Dong Yun Hyun, Youn-Il Park, Changsoo Kim, Tae-Ho Lee, Hyun Uk Kim, Moon Soo Soh, Yi Lee, Jun Gyo In, Heui-Soo Kim, Yong-Min Kim, Deok-Chun Yang, Rod A Wing, Dong-Yup Lee, Andrew H Paterson, Tae-Jin Yang
Panax ginseng C. A. Meyer, reputed as the king of medicinal herbs, has slow growth, long generation time, low seed production, and complicated genome structure that hamper its study. Here, we unveil the genomic architecture of tetraploid P. ginseng by de novo genome assembly, representing 2.98 Gbp with 59,352 annotated genes. Resequencing data indicated that diploid Panax species diverged in association with global warming in Southern Asia, and two North American species evolved via two inter-continental migrations...
March 31, 2018: Plant Biotechnology Journal
Jia-Liang Gao, Guang Chen, Hao-Qiang He, Jie Wang
For the characteristics of high stability, high conservation between species, and tissue specificity, circular RNA(circRNA) has been expected to become a new molecular biomarker for the clinical diagnosis, treatment and prognosis, and the potential target for targeted therapy. Study on the traditional Chinese medicine(TCM) syndrome includes not only the macro indexes collected by using four traditional methods of diagnosis, but also contains some micro information that can not be achieved by using the four traditional diagnosis methods...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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