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https://www.readbyqxmd.com/read/29907231/socioeconomics-affecting-quality-outcomes-in-asian-trauma-patients-within-the-united-states
#1
Krista L Haines, Suresh Agarwal, Hee Soo Jung
INTRODUCTION: Asian-Americans and Pacific Islanders are often considered as a uniform group when examining race in health outcomes. However, the generally favorable economic outcomes in this group belie significant socioeconomic variance between its heterogeneous subgroups. This study evaluates the impact of socioeconomic status on the health outcomes of Asian trauma patients. METHODS: From 2012 to 2015, 52,704 Asians who presented to trauma centers were registered with the National Trauma Data Bank with known disposition...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29895215/rac2-promotes-abnormal-proliferation-of-quiescent-cells-by-enhanced-junb-expression-via-the-mal-srf-pathway
#2
Hailong Pei, Ziyang Guo, Ziyang Wang, Yingchu Dai, Lijun Zheng, Lin Zhu, Jian Zhang, Wentao Hu, Jing Nie, Weidong Mao, Xianghong Jia, Bingyan Li, Tom K Hei, Guangming Zhou
Radiation-induced lung injury (RILI) occurs most often in radiotherapy of lung cancer, esophageal cancer, and other thoracic cancers. The occurrence of RILI is a complex process that includes a variety of cellular and molecular interactions, which ultimately result in carcinogenesis. However, the underlying mechanism is unknown. Here we show that Ras-related C3 botulinum toxin substrate 2 (RAC2) and transcription factor jun-B (JUNB) were upregulated in non-small cell carcinoma (NSCLC) tissues and were associated with poor prognoses for NSCLC patients...
June 13, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29891467/tobacco-smoking-alcohol-drinking-and-betel-quid-chewing-behaviors-development-and-use-of-a-web-based-survey-system
#3
Kuo-Yao Hsu, Yun-Fang Tsai, Chu-Ching Huang, Wen-Ling Yeh, Kai-Ping Chang, Chen-Chun Lin, Ching-Yen Chen, Hsiu-Lan Lee
BACKGROUND: Smoking tobacco, drinking alcohol, and chewing betel quid are health-risk behaviors for several diseases, such as cancer, cardiovascular disease, and diabetes, with severe impacts on health. However, health care providers often have limited time to assess clients' behaviors regarding smoking tobacco, drinking alcohol, and chewing betel quid and intervene, if needed. OBJECTIVE: The objective of this study was to develop a Web-based survey system; determine the rates of tobacco-smoking, alcohol-drinking, and betel-quid-chewing behaviors; and estimate the efficiency of the system (time to complete the survey)...
June 11, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29797467/the-critical-importance-of-pharyngeal-contractile-forces-on-the-validity-of-intrabolus-pressure-as-a-predictor-of-impaired-pharyngo-esophageal-junction-compliance
#4
M M Szczesniak, P I Wu, J Maclean, T I Omari, I J Cook
INTRODUCTION: Restrictive defects of the pharyngo-esophageal junction (PEJ) are common in both structural and neurological disorders and are amenable to therapies aiming to reduce outflow resistance. Intrabolus pressure (IBP) acquired with high-resolution manometry and impedance (HRMI) is an indicator of resistance and a marker of reduced PEJ compliance. Constraints and limitations of IBP as well as the optimal IBP parameter remain undefined. AIMS: To determine: (i) the impact of peak pharyngeal pressure (PeakP) on the diagnostic accuracy of IBP for the detection of a restrictive defect at the PEJ and (ii) the optimal IBP parameter for this purpose...
May 24, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29795991/gastrointestinal-lesions-in-african-american-patients-with-iron-deficiency-anemia
#5
Hassan Brim, Anahita Shahnazi, Mehdi Nouraie, Dilhana Badurdeen, Adeyinka O Laiyemo, Tahmineh Haidary, Ali Afsari, Hassan Ashktorab
Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients. Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods: We reviewed medical records (n = 422) of patients referred for evaluation of IDA from 2008 to 2012...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29789277/applicability-of-a-web-based-individualized-exercise-intervention-in-patients-with-liver-disease-cystic-fibrosis-esophageal-cancer-and-psychiatric-disorders-process-evaluation-of-4-ongoing-clinical-trials
#6
Daniel Pfirrmann, Nils Haller, Yvonne Huber, Patrick Jung, Klaus Lieb, Ines Gockel, Krystyna Poplawska, Jörn Markus Schattenberg, Perikles Simon
BACKGROUND: In the primary and secondary prevention of civilization diseases, regular physical activity is recommended in international guidelines to improve disease-related symptoms, delay the progression of the disease, or to enhance postoperative outcomes. In the preoperative context, there has been a paradigm shift in favor of using preconditioning concepts before surgery. Web-based interventions seem an innovative and effective tool for delivering general information, individualized exercise recommendations, and peer support...
May 22, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29788876/exploiting-significance-of-physical-exercise-in-prevention-of-gastrointestinal-disorders
#7
Jan Bilski, Agnieszka Mazur-Bialy, Marcin Magierowski, Slawomir Kwiecien, Dagmara Wojcik, Agata Ptak-Belowska, Marcin Surmiak, Aneta Targosz, Katarzyna Magierowska, Tomasz Brzozowski
BACKGROUND: Physical activity can be involved in the prevention of gastrointestinal (GI)-tract diseases, however, the results regarding the volume and the intensity of exercise considered as beneficial for protection of gastrointestinal organs are conflicting. AIMS AND METHODS: The main objective of this review is to provide a comprehensive and updated overview on the beneficial and harmful effects of physical activity on the gastrointestinal tract. We attempted to discuss recent evidence regarding the association between different modes and intensity levels of exercise and physiological functions of the gut and gut pathology...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29771950/biophotonic-detection-of-high-order-chromatin-alterations-in-field-carcinogenesis-predicts-risk-of-future-hepatocellular-carcinoma-a-pilot-study
#8
Richard Kalman, Andrew Stawarz, David Nunes, Di Zhang, Mart A Dela Cruz, Arpan Mohanty, Hariharan Subramanian, Vadim Backman, Hemant K Roy
PURPOSE: Hepatocellular carcinoma (HCC) results from chronic inflammation/cirrhosis. Unfortunately, despite use of radiological/serological screening techniques, HCC ranks as a leading cause of cancer deaths. Our group has used alterations in high order chromatin as a marker for field carcinogenesis and hence risk for a variety of cancers (including colon, lung, prostate, ovarian, esophageal). In this study we wanted to address whether these chromatin alterations occur in HCC and if it could be used for risk stratification...
2018: PloS One
https://www.readbyqxmd.com/read/29723766/timing-and-risk-of-mood-disorders-requiring-psychotropics-in-long-term-survivors-of-adult-cancers-a-nationwide-cohort-study
#9
Wen-Kuan Huang, Yeong-Yuh Juang, Chia-Chi Chung, Shu-Hao Chang, John Wen-Cheng Chang, Yung-Chang Lin, Hung-Ming Wang, Hsien-Kun Chang, Jen-Shi Chen, Chieh-Sheng Tsai, Kuang-Hui Yu, Chang-Fu Kuo, Lai-Chu See
BACKGROUND: The increasing number of long-term cancer survivors over the past few decades poses the challenge of mental health care needs. However, little is known about risks of mood disorders in long-term cancer survivors. METHODS: Long-term survivors (≥5 years) of adult cancers (LSAC) (n = 190,748) newly diagnosed between January 1, 2000 and December 31, 2007 were matched with one control. The primary outcome was diagnosis of mood disorders requiring psychotropics...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679342/fundoplication-with-180-degree-wrap-during-esophagogastrostomy-after-robotic-proximal-gastrectomy-for-early-gastric-cancer
#10
Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Keiji Hayata, Shimpei Maruoka, Hiroki Yamaue
BACKGROUND: Compared with total gastrectomy, proximal gastrectomy (PG) has potential advantages from a nutritional perspective, such as anemia and postoperative loss of body weight. However, PG is associated with some postoperative functional disorders, such as reflux esophagus (13-31%) and anastomotic stenosis (3-29%).1 We therefore developed a new procedure for fundoplication during esophago-gastrostomy after robotic PG (RPG). METHODS: We performed RPG for early gastric cancer localized in the upper third of the stomach using the da Vinci Surgical System (Intuitive, Sunnyvale, CA)...
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29644781/inpp4b-overexpression-and-c-kit-downregulation-in-human-achalasia
#11
E Bonora, F Bianco, A Stanzani, F Giancola, A Astolfi, V Indio, C Evangelisti, A M Martelli, E Boschetti, M Lugaresi, A Ioannou, F Torresan, V Stanghellini, P Clavenzani, M Seri, A Moonen, K Van Beek, M Wouters, G E Boeckxstaens, G Zaninotto, S Mattioli, R De Giorgio
BACKGROUND: Achalasia is a rare motility disorder characterized by myenteric neuron and interstitial cells of Cajal (ICC) abnormalities leading to deranged/absent peristalsis and lack of relaxation of the lower esophageal sphincter. The mechanisms contributing to neuronal and ICC changes in achalasia are only partially understood. Our goal was to identify novel molecular features occurring in patients with primary achalasia. METHODS: Esophageal full-thickness biopsies from 42 (22 females; age range: 16-82 years) clinically, radiologically, and manometrically characterized patients with primary achalasia were examined and compared to those obtained from 10 subjects (controls) undergoing surgery for uncomplicated esophageal cancer (or upper stomach disorders)...
April 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29563965/avoiding-diagnostic-errors-in-psychosomatic-medicine-a-case-series-study
#12
Atsuko Koyama, Yoichi Ohtake, Kanae Yasuda, Kiyohiro Sakai, Ryo Sakamoto, Hiromichi Matsuoka, Hirokuni Okumi, Toshiko Yasuda
Background: Non-organic lesions or diseases of unknown origin are sometimes misdiagnosed as "psychogenic" disorders or "psychosomatic" diseases. For the quality of life and safety of patients, recent attention has focused on diagnostic error. The aim of this study was to clarify the factors that affected misdiagnoses in psychosomatic medicine by examining typical cases and to explore strategies that reduce diagnostic errors. Case presentation: The study period was from January 2001 to August 2017...
2018: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/29519608/the-impact-of-preoperative-investigations-on-the-management-of-bariatric-patients-results-of-a-cohort-of-more-than-1200-cases
#13
Romano Schneider, Ioannis Lazaridis, Marko Kraljević, Christoph Beglinger, Bettina Wölnerhanssen, Ralph Peterli
BACKGROUND: Despite the increasing use of bariatric surgery as the most effective treatment of morbid obesity, there is still no consensus on its preoperative diagnostic workup. The aim of this study was to identify the pathologies of the endoscopic and radiologic investigations before performing bariatric surgery and to evaluate their impact on the patient management. METHODS: Retrospective analysis of prospectively collected data of 1225 consecutive patients who underwent laparoscopic Roux-en-Y gastric bypass (n = 834) or sleeve gastrectomy (n = 391) at our institution...
May 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29509534/esophageal-reconstruction-with-the-stomach-a-functional-dilemma
#14
Dragoş Predescu, Silviu Constantinoiu
Background: A few decades ago, esophageal substitution was mainly dedicated particularly in postcaustic esophageal stenosis; currently, the reconstruction has expanded its palette of indications to other areas of benign esophageal pathology (severe motor disorders, esophageal achalasia with multiple relapses, peptic stenosis, etc.) but has also become a quasi-obligatory final time in the esophagectomy for cancer whenever it is possible. The techniques of esophageal reconstruction using the stomach, regardless of the indication and the chosen technical option, remain a valuable and effective method...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29477220/thiamin
#15
REVIEW
Derrick Lonsdale
Starting with a brief history of beriberi and the discovery that thiamin deficiency is its cause, the symptoms and signs are reviewed. None are pathognomonic. The disease has a low mortality and a long morbidity. The appearance of the patient can be deceptive, often being mistaken for psychosomatic disease in the early stages. The chemistry of thiamin and the laboratory methodology for depicting its deficiency are outlined. The diseases associated with thiamin deficiency, apart from malnutrition, include a number of genetically determined conditions where mutations, either in the cofactor relationship or a transporter, provide the etiology...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29336226/identifying-metrics-before-and-after-readmission-following-head-and-neck-surgery-and-factors-affecting-readmission-rate
#16
Sidharth V Puram, Neil Bhattacharyya
Objectives Determine nationally representative readmission rates after head and neck cancer (HNCA) surgery and factors associated with readmission. Study Design Cross-sectional analysis of admissions database. Methods The 2013 Nationwide Readmissions Database was analyzed for HNCA surgery admissions and subsequent readmission within 30 days. The readmission rate, length of stay (LOS), disposition, mortality rate, and total charges were determined. Diagnoses and procedures upon readmission were quantified. Factors that were associated with readmission were determined...
May 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29310400/clinical-analysis-of-hyperkalemia-after-esophagectomy-a-case-report
#17
Qiang Chen, Wei-Guo Zhang, Shu-Chang Chen
RATIONALE: The occurrence of hyperkalemia after esophagectomy is clinically rare. Patients who underwent esophagectomy often have a serum potassium level due to perioperative reduced intake, fluids loss, consumption and other reasons. These patients often require the artificial administration of potassium. Rapid fluid loss and physiological consumption lead to the deficiency of potassium, even hypokalemia. Patients often require the addition of a large amount of potassium after operation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29285832/nimotuzumab-combined-with-concurrent-chemoradiotherapy-in-japanese-patients-with-esophageal-cancer-a-phase-i-study
#18
Ken Kato, Takashi Ura, Wasaburo Koizumi, Satoru Iwasa, Chikatoshi Katada, Mizutomo Azuma, Satoshi Ishikura, Yoshinori Nakao, Hiroshi Onuma, Kei Muro
Nimotuzumab is a humanized anti-epidermal growth factor receptor IgG1 monoclonal antibody. This phase I study assessed the tolerability, safety, efficacy, and pharmacokinetics of nimotuzumab in combination with chemoradiotherapy in Japanese patients with esophageal cancer. Patients with stage II, III, and IV esophageal cancer were enrolled. Patients were planned to receive nimotuzumab (level 1: 200 mg/wk for 25 weeks; or level 2: 400 mg/wk in the chemoradiation period, 400 mg biweekly in an additional chemotherapy period [8 weeks after the chemoradiation period] and a maintenance therapy period [after chemotherapy to 25 weeks]) combined with cisplatin (75 mg/m2 on day 1) and fluorouracil (1000 mg/m2 on days 1-4) in the chemoradiation and additional chemotherapy periods...
March 2018: Cancer Science
https://www.readbyqxmd.com/read/29246590/developing-a-national-simulation-based-surgical-skills-bootcamp-in-general-thoracic-surgery
#19
Colin Schieman, Hideki Ujiie, Laura Donahoe, Waël Hanna, Richard Malthaner, Simon Turner, Kasia Czarnecka, Kazuhiro Yasufuku
BACKGROUND: The use surgical simulation across all subspecialties has gained widespread adoption in the last decade. A number of factors, including the small number of trainees, identified gaps in surgical skill training from cross-sectional surveys, increased national collaboration, and support from the national specialty committee identified a need to construct a surgical skills "bootcamp" in thoracic surgery in Canada. OBJECTIVE: The goals of the surgical skills bootcamp, as identified by the residency training program directors and the national specialty committee were to create a national, centralized, simulation-based skills workshop that focused on key foundational procedures within thoracic surgery, particularly those identified as areas of weakness by former residents; to smooth the transition to intraoperative teaching; to provide exposure to important but not necessarily universally available procedures such as advanced endoscopy; to teach non-medical expert competencies, and lastly to provide a venue for networking for residents across the country...
December 12, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29234939/the-role-of-preoperative-high-resolution-manometry-in-predicting-dysphagia-after-laparoscopic-nissen-fundoplication
#20
Sonam Kapadia, Turner Osler, Allen Lee, Edward Borrazzo
BACKGROUND: Laparoscopic fundoplication is an accepted surgical management of refractory gastro-esophageal reflux disease (GERD). The use of high resolution esophageal manometry (HRM) in preoperative evaluation is often applied to determine the degree of fundoplication to optimize reflux control while minimizing adverse sequela of postoperative dysphagia. OBJECTIVE: Assess the role of preoperative HRM in predicting surgical outcomes, specifically risk assessment of postoperative dysphagia and quality of life, among patients receiving laparoscopic Nissen fundoplication for GERD with immediate postoperative (< 4 weeks clinic), short-term (3-month clinic), and long-term (34 ± 10...
May 2018: Surgical Endoscopy
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