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https://www.readbyqxmd.com/read/28165652/candidate-susceptibility-variants-for-esophageal-squamous-cell-carcinoma
#1
Iikki Donner, Riku Katainen, Tomas Tanskanen, Eevi Kaasinen, Mervi Aavikko, Kristian Ovaska, Miia Artama, Eero Pukkala, Lauri A Aaltonen
Esophageal cancer is common worldwide, and often fatal. The major histological subtype is esophageal squamous cell carcinoma (ESCC). ESCC shows familial aggregation and high heritability. Mutations in RHBDF2 cause tylosis, a very rare disorder characterized by high life-time risk of ESCC, but no other well-established predisposition genes have been identified. To identify candidate susceptibility variants for ESCC we utilized the Population Information System and the Finnish cancer registry to find study materials by clustering ESCC patients by family name at birth and municipality at birth...
February 6, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28163045/analysis-of-preoperative-metabolic-risk-factors-affecting-the-prognosis-of-patients-with-esophageal-squamous-cell-carcinoma-the-fujian-prospective-investigation-of-cancer-fiesta-study
#2
Feng Peng, Dan Hu, Xiandong Lin, Gang Chen, Binying Liang, Hejun Zhang, Xiaoqun Dong, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
Some metabolic factors have been shown to be associated with an increased risk of esophageal cancer; however the association with its prognosis is rarely reported. Here, we assessed the prediction of preoperative metabolic syndrome and its single components for esophageal cancer mortality by analyzing a subset of data from the ongoing Fujian prospective investigation of cancer (FIESTA) study. Between 2000 and 2010, patients who underwent three-field lymphadenectomy were eligible for inclusion. Blood/tissue specimens, demographic and clinicopathologic data were collected at baseline...
January 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28131793/rosacea-and-risk-of-cancer-in-denmark
#3
Alexander Egeberg, Joseph F Fowler, Gunnar H Gislason, Jacob P Thyssen
BACKGROUND: Rosacea is a common facial skin disorder with an estimated prevalence of 5-10% among Caucasians. OBJECTIVE: We compared cancer incidence in patients previously diagnosed with rosacea with that in the general population. METHODS: Nationwide cohort study of the Danish population using individual-level linkage of administrative registers. All Danish citizens aged ≥18years were followed from January 1st 2008 to December 31st 2012...
January 26, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28120720/the-role-of-epidermal-growth-factor-receptor-in-the-management-of-gastrointestinal-carcinomas-present-status-and-future-perspectives
#4
Malik Quasir Mahmood, Shakti Dhar Shukla, Kamal Dua, Madhur D Shastri
BACKGROUND: The global burden of gastrointestinal cancers, including colorectal, stomach, and esophageal cancers is rising steadily. Several therapeutic approaches have been considered for the treatment of GI carcinomas. However, none showed to halt or cure the disease. There is a need to develop effective targeted molecular therapies; mainly to overcome the adverse effects of currently used treatment regimens, as well as, to benefit a large proportion of cancer patients who do not respond well to chemotherapeutics...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28086818/narrow-band-imaging-versus-lugol-chromoendoscopy-to-diagnose-squamous-cell-carcinoma-of-the-esophagus-a-systematic-review-and-meta-analysis
#5
Flavio Hiroshi Ananias Morita, Wanderley Marques Bernardo, Edson Ide, Rodrigo Silva Paula Rocha, Julio Cesar Martins Aquino, Mauricio Kazuyoshi Minata, Kendi Yamazaki, Sergio Barbosa Marques, Paulo Sakai, Eduardo Guimarães Hourneaux de Moura
BACKGROUND: In the early stage esophageal cancer, changes in the mucosa are subtle and pass unnoticed in endoscopic examinations using white light. To increase sensitivity, chromoscopy with Lugol's solution has been used. Technological advancements have led to the emergence of virtual methods of endoscopic chromoscopy, including narrow band imaging (NBI). NBI enhances the relief of the mucosa and the underlying vascular pattern, providing greater convenience without the risks inherent to the use of vital dye...
January 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28062361/redox-signaling-in-the-gastrointestinal-tract
#6
REVIEW
Salvador Pérez, Raquel Taléns-Visconti, Sergio Rius-Pérez, Isabela Finamor, Juan Sastre
Redox signaling regulates physiological self-renewal, proliferation, migration and differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch signaling pathways mainly through NADPH oxidases (NOXs). In the intestine, intracellular and extracellular thiol redox status modulates the proliferative potential of epithelial cells. Furthermore, commensal bacteria contribute to intestine epithelial homeostasis through NOX1- and dual oxidase 2-derived reactive oxygen species (ROS). The loss of redox homeostasis is involved in the pathogenesis and development of a wide diversity of gastrointestinal disorders, such as Barrett's esophagus, esophageal adenocarcinoma, peptic ulcer, gastric cancer, ischemic intestinal injury, celiac disease, inflammatory bowel disease and colorectal cancer...
January 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28049452/waiting-time-for-cancer-treatment-and-mental-health-among-patients-with-newly-diagnosed-esophageal-or-gastric-cancer-a-nationwide-cohort-study
#7
Huan Song, Fang Fang, Unnur Valdimarsdóttir, Donghao Lu, Therese M-L Andersson, Christina Hultman, Weimin Ye, Lars Lundell, Jan Johansson, Magnus Nilsson, Mats Lindblad
BACKGROUND: Except for overall survival, whether or not waiting time for treatment could influences other domains of cancer patients' overall well-being is to a large extent unknown. Therefore, we performed this study to determine the effect of waiting time for cancer treatment on the mental health of patients with esophageal or gastric cancer. METHODS: Based on the Swedish National Quality Register for Esophageal and Gastric Cancers (NREV), we followed 7,080 patients diagnosed 2006-2012 from the time of treatment decision...
January 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28049283/application-of-photodynamic-therapy-in-gastrointestinal-disorders-an-outdated-or-re-emerging-technique
#8
REVIEW
Han Hee Lee, Myung-Gyu Choi, Tayyaba Hasan
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported...
January 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27975337/hospital-volume-and-adverse-events-following-esophageal-endoscopic-submucosal-dissection-in-japan
#9
Hiroyuki Odagiri, Hideo Yasunaga, Hiroki Matsui, Shigeru Matsui, Kiyohide Fushimi, Mitsuru Kaise
Background and study aims Esophageal endoscopic submucosal dissection (ESD) has gradually acquired popularity as a minimally invasive surgery for early cancers not only in Japan, but also in other countries. However, most reported outcomes have been based on relatively small samples of patients from specialized centers. Therefore, the association between hospital volume and the rate of adverse events following esophageal ESD has been poorly understood. Patients and methods Using a nationwide administrative database in Japan, we identified patients who underwent esophageal ESD between 1 July 2007 and 31 March 2013...
December 14, 2016: Endoscopy
https://www.readbyqxmd.com/read/27966311/the-increasing-incidence-of-esophageal-squamous-cell-carcinoma-in-women-in-turkey
#10
Atila Eroğlu, Yener Aydın, Bayram Altuntaş, Betül Gündoğdu, Ömer Yılmaz
BACKGROUND/AIM: This study assessed the trend changes in the histological types of esophageal cancer in a 25-year period in eastern Turkey. MATERIALS AND METHODS: We searched all cases of esophageal cancer from 1990 to 2015 according to their histological diagnosis and sex, grouping the patients in 5-year time periods to evaluate time trends. RESULTS: We identified 1462 cases of esophageal cancer. In terms of patient make-up, 742 were male and 720 were female...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27862680/the-natural-history-of-gastro-esophageal-reflux-disease-a-comprehensive-review
#11
REVIEW
E Savarino, N de Bortoli, C De Cassan, M Della Coletta, O Bartolo, M Furnari, A Ottonello, E Marabotto, G Bodini, V Savarino
Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs related to the diagnosis, treatment and surveillance of GERD and its complications. The aim of this review is to provide current information regarding the natural history of GERD, taking into account the evolution of its definition and the worldwide gradual change of its epidemiology...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27804885/the-functions-of-heparanase-in-human-diseases
#12
Hao Jin, Shaobo Zhou
The study of the heparanase has long been paid wide attention. Heparanase ,an endo-β-D-glucuronidase, is capable of specifically degrading heparan sulfate(HS), one of the excellular matrix(ECM) components. It exerts its enzymatic activity catalyzing the cleavage of the β (1,4)-glycosidic bond between glucuronic acid and glucosamine residue. HS cleavage results in remodelling of the extracellular matrix as well as in regulating the release of many HS-linked molecules such as growth factors, cytokines and enzymes involved in inflammation, wound healing and tumour invasion...
November 1, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27778325/a-possible-link-between-famine-exposure-in-early-life-and-future-risk-of-gastrointestinal-cancers-implications-from-age-period-cohort-analysis
#13
Shao-Hua Xie, Jesper Lagergren
The Chinese famine in 1958-1962 was one of the worst in human history, but its potential influence on cancer risks is uncertain. Using cancer incidence data in Shanghai, China, during 1983-2007, we calculated age-specific incidence rates of gastrointestinal cancers in birth cohorts exposed to the Chinese famine in different periods of life and a non-exposed reference cohort. Age-period-cohort regressions estimated the overall relative risks of gastrointestinal cancers in each birth cohort. A total of 212,098 new cases of gastrointestinal cancer were identified during the study period (129,233 males and 82,865 females), among whom 18,146 had esophageal cancer, 71,011 gastric cancer, 55,864 colorectal cancer, 42,751 liver cancer, 9,382 gallbladder cancer and 14,944 had pancreatic cancer...
February 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27684819/impact-of-alcohol-consumption-and-body-mass-index-on-mortality-from-nonneoplastic-liver-diseases-upper-aerodigestive-tract-cancers-and-alcohol-use-disorders-in-korean-older-middle-aged-men-prospective-cohort-study
#14
Sang-Wook Yi, Jae-Seok Hong, Jee-Jeon Yi, Heechoul Ohrr
Alcohol use is a leading risk factor for the global disease burden including liver diseases. However, the combined effect of alcohol use and body mass index (BMI) on alcohol-related diseases has seldom been examined. We examined whether alcohol consumption and BMI could act together to increase mortality from nonneoplastic liver diseases, upper aero-digestive tract (UADT) cancers, and alcohol use disorders (AUD) in middle-aged Korean men.107,735 men (mean age, 58.8 years) participated in a postal survey in 2004 and were followed until 2010, by linkage to national death records...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27684497/anti-p200-laminin-%C3%AE-1-pemphigoid-associated-with-metastatic-oesophageal-cancer
#15
LETTER
S Goetze, A-K Dumke, D Zillikens, U C Hipler, P Elsner
No abstract text is available yet for this article.
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27626495/nationwide-population-based-study-reveals-increased-malignancy-risk-in-taiwanese-liver-transplant-recipients
#16
Yung Fong Tsai, Hsiu Pin Chen, Fu Chao Liu, Shih Hao Liu, Chun Yu Chen, Chih Wen Cheng, Jr Rung Lin
Post-transplant malignancy is a major cause of late mortality for liver transplant recipients (LTRs). This nationwide population-based cohort study investigated the cancer type, incidence, and risk factors associated with post-transplant malignancies in 2938 Taiwanese LTRs who underwent transplantation between 1998 and 2012. Data from the National Health Insurance Research Database were extracted on the basis of the International Classification of Disease, Ninth Revision, Clinical Modification codes. Among these patients, 284 post-transplant malignancies were diagnosed...
September 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27585977/micrornas-in-allergic-disease
#17
Eishika Dissanayake, Yuzaburo Inoue
PURPOSE OF REVIEW: MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs that are increasingly being recognized as important epigenetic regulators. They have been implicated in the pathogenesis of many diseases including cancer, cardiovascular diseases, connective tissue diseases, and neuromuscular disorders. RECENT FINDINGS: A few miRNAs have already been recognized as a core set of miRNAs important in allergic inflammation. These include let-7, miR-21, miR-142, and miR-146...
September 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27540430/cowden-syndrome-detected-by-fdg-pet-ct-in-an-endometrial-cancer-patient
#18
Yun Hee Kang, Hye Kyung Lee, Geon Park
Cowden syndrome (CS) is a rare autosomal dominant disorder characterized by multiple hamartomas in various tissues and cancers (breast, thyroid, and endometrium). We report CS of the esophagus and gastrointestinal tract that was incidentally detected by positron emission tomography/computed tomography (PET/CT) at postoperative surveillance in an endometrial cancer patient. PET/CT showed mildly increased FDG uptake along the entire esophagus and stomach. Upper GI endoscopy and histologic examination revealed glycogenic acanthosis of the esophagus and several hundred gastric polyps...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27462189/unintentional-long-term-esophageal-stenting-due-to-a-complete-response-in-a-patient-with-stage-uicc-iv-adenocarcinoma-of-the-gastroesophageal-junction
#19
Anna Paeschke, Christian Bojarski, Susanne Küpferling, Thomas Hucklenbroich, Britta Siegmund, Severin Daum
Endoscopic stent implantation is a common short-treatment option in palliative settings in patients with esophageal cancer. Advanced disease is associated with low survival rates; therefore, data on the long-term outcome are limited. So far, cases of long-term remission or even cure of metastasized adenocarcinoma of the gastroesophageal junction or stomach (AGS) have only been reported from Asia. A 51-year-old male patient primarily diagnosed with metastasized adenocarcinoma of the gastroesophageal junction (GEJ) [type I, cT3cN+cM1 (hep), CEA positive, UICC stage IV] received palliative esophageal stenting with a self-expandable metal stent...
May 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27434041/percutaneous-endoscopic-gastrostomy-in-direct-puncture-technique-when-why-and-how
#20
Hartmut Schaefer, Carlo Vivaldi, Till Herbold, Sebastian Brinkmann, Martin Maus, Marc Bludau, Ulrich Töx, Tobias Goeser, Arnulf H Hoelscher, Jessica M Leers
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) placed in the pull through (PT) technique is a common procedure to restore enteral feeding in patients with swallowing disorders. Limitations of this technique are patients with obstruction of the pharynx or esophagus or with an esophageal stent. We report our experience with the direct puncture (DP) PEG device. METHODS: We included 154 patients (55 women). One hundred forty patients had cancer. After passing the endoscope into the stomach, 4 gastropexies were performed with a gastropexy device and the PEG was placed with the introducer method...
2017: Digestive Surgery
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