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Digestive Diseases

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https://www.readbyqxmd.com/read/29350914/cys34-adductomes-differ-between-patients-with-chronic-lung-or-heart-disease-and-healthy-controls-in-central-london
#1
Sa Liu, Hasmik Grigoryan, William Matthew Bell Edmands, Sonia Dagnino, Rudy Sinharay, Paul Cullinan, Peter Collins, Kian Fan Chung, Benjamin M Barratt, Frank J Kelly, Paolo Vineis, Stephen M Rappaport
Oxidative stress generates reactive species that modify proteins, deplete antioxidant defenses and contribute to chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD). To determine whether protein modifications differ between COPD or IHD patients and healthy subjects, we performed untargeted analysis of adducts at the Cys34 locus of human serum albumin (HSA). Biospecimens were obtained from nonsmoking participants from London, U.K., including healthy subjects (n=20) and patients with COPD (n=20) or IHD (n=10)...
January 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29349265/children-s-migration-and-chronic-illness-among-older-parents-left-behind-in-china
#2
Maria Evandrou, Jane Falkingham, Min Qin, Athina Vlachantoni
The relationship between adult children's migration and the health of their older parents 'left behind' is an emerging research area and existing studies reflect mixed findings. This study aims to investigate the association between having migrant (adult) children and older parents' chronic illness in China, using chronic stomach or other digestive diseases as a proxy. Secondary analysis of the national baseline survey of the 2011 China Health and Retirement Longitudinal Study (CHARLS) was conducted. Analyses were conducted in a total of sample of 6495 individuals aged 60 years and above from 28 out of 31 provinces in China, who had at least one child at the baseline survey...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29348718/qualitative-and-quantitative-analysis-of-furosine-in-fresh-and-processed-ginsengs
#3
Yali Li, Xiaoxu Liu, Lulu Meng, Yingping Wang
Background: Furosine (ɛ-N-2-furoylmethyl-L-lysine, FML) is an amino acid derivative, which is considered to be an important indicator of the extent of damage (deteriorating the quality of amino acid and proteins due to a blockage of lysine and a decrease in the digestibility of proteins) during the early stages of the Maillard reaction. In addition, FML has been proven to be harmful because it is closely related to a variety of diseases such as diabetes. The qualitative analysis of FML in fresh and processed ginsengs was confirmed using HPLC-MS...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348584/quail-egg-homogenate-alleviates-food-allergy-induced-eosinophilic-esophagitis-like-disease-through-modulating-par-2-transduction-pathway-in-peanut-sensitized-mice
#4
Priscilia Lianto, Shiwen Han, Xinrui Li, Fredrick Onyango Ogutu, Yani Zhang, Zhuoyan Fan, Huilian Che
The present pharmacotherapy for eosinophilic esophagitis (EoE) fundamentally depend on inhaled corticosteroids. Despite the fact that oral intake of topical steroids can be successful in restricting EoE-related inflammation, there are concerns with respect to the long term utilization of steroids, especially in kids. In the current research, we assess the effect of quail egg, which is reportedly a known serine protease inhibitor, on symptomatology and immune responses in a peanut-sensitized mouse model of food allergy induced EoE...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344869/isolation-of-amyloid-plaques-and-neurofibrillary-tangles-from-archived-alzheimer-s-disease-tissue-using-laser-capture-microdissection-for-downstream-proteomics
#5
Eleanor Drummond, Shruti Nayak, Geoffrey Pires, Beatrix Ueberheide, Thomas Wisniewski
Here, we describe a new method that allows localized proteomics of amyloid plaques and neurofibrillary tangles (NFTs), which are the two pathological hallmarks of Alzheimer's disease (AD). Amyloid plaques and NFTs are visualized using immunohistochemistry and microdissected from archived, formalin-fixed paraffin-embedded (FFPE) human tissue samples using laser-capture microdissection. The majority of human tissue specimens are FFPE; hence the use of this type of tissue is a particular advantage of this technique...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29344287/role-of-mir-483-in-digestive-tract-cancers-from-basic-research-to-clinical-value
#6
REVIEW
Wei Zhou, Wanli Yang, Jiaojiao Ma, Hongwei Zhang, Zeng Li, Lei Zhang, Jinqiang Liu, Zhenyu Han, Hu Wang, Liu Hong
Digestive tract cancers (DTCs) is the most common malignant tumors in the world. Despite surgery and medical technology have witnessed the increasing development and sharp advancement in the past decade, DTCs remain a critical concern with high morbidity and mortality. Since a class of small noncoding RNAs termed miRNAs were identified several years ago, increasing studies have attempted to illustrate the relationship between the specific miRNAs dysregulated expression levels and the diseases phenotypic changes...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29342262/preliminary-study-of-1940-nm-thulium-laser-usage-in-peroral-endoscopic-myotomy-for-achalasia
#7
J Liu, Y Jiao, Y Niu, L Yu, M Ji, S Zhang
Esophageal achalasia is a type of motility disorder characterized by incomplete relaxation of lower esophageal sphincter (LES) and absence of esophageal peristalsis. Peroral endoscopic myotomy (POEM) is a new treatment option for achalasia that is less invasive, more effective, and safe as compared to surgery. High-frequency electrotome is commonly used in POEM, but takes longer time to make the tunnel in the esophagus and causes many complications. The thulium laser decreases the risk of bleeding and perforation in endoscopy but has not been reported in digestive diseases, especially in POEM...
January 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29341867/genetic-and-microbiome-influence-on-lipid-metabolism-and-dyslipidemia
#8
Maria Matey Hernandez, Frances Mk Mk Williams, Tilly Potter, Ana M Valdes, Tim Spector, Cristina Menni
Disruption in the metabolism of lipids is broadly classified under dyslipidemias and relate to the concentration of lipids in the blood. Dyslipidemia is a predictor of cardio-metabolic disease including obesity. Traditionally, the large inter-individual variation has been related to genetic factors and diet. Genome-wide association studies have identified over 150 loci related to abnormal lipid levels, explaining approximately 40% of the total variation. Part of the unexplained variance has been attributed to environmental factors including diet, but the extent of the dietary contribution remains unquantified...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29341114/recombinant-human-hepatocyte-growth-factor-provides-protective-effects-in-celurein-induced-acute-pancreatitis-in-mice
#9
Mayrel Palestino-Domínguez, Mario Pelaez-Luna, Roberto Lazzarini-Lechuga, Ignacio Rodríguez-Ochoa, Verónica Souza, Roxana U Miranda, Benjamín Pérez-Aguilar, Leticia Bucio, Jens U Marquardt, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Ruiz
Acute pancreatitis is a multifactorial disease associated with profound changes of the pancreas induced by release of digestive enzymes that lead to increase in proinflammatory cytokine production, excessive tissue necrosis, edema, and bleeding. Elevated levels of hepatocyte growth factor (HGF) and its receptor c-Met have been observed in different chronic and acute pancreatic diseases including experimental models of acute pancreatitis. In the present study, we investigated the protective effects induced by the recombinant human HGF in a mouse model of cerulein-induced acute pancreatitis...
January 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29340042/identification-of-potential-genetic-causal-variants-for-rheumatoid-arthritis-by-whole-exome-sequencing
#10
Ying Li, Elaine Lai-Han Leung, Hudan Pan, Xiaojun Yao, Qingchun Huang, Min Wu, Ting Xu, Yuwei Wang, Jun Cai, Runze Li, Wei Liu, Liang Liu
Rheumatoid arthritis (RA) is a highly prevalent chronic autoimmune disease. However, genetic and environmental factors involved in RA pathogenesis are still remained largely unknown. To identify the genetic causal variants underlying pathogenesis and disease progression of RA patients, we undertook the first comprehensive whole-exome sequencing (WES) study in a total of 124 subjects including 58 RA cases and 66 healthy controls in Han Chinese population. We identified 378 novel genes that were enriched with deleterious variants in RA patients using a gene burden test...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339955/highlights-in-functional-dyspepsia-treatment-from-digestive-disease-week-2017-may-6-9-2017-%C3%A2-chicago-illinois
#11
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29339411/flagellin-glycoproteomics-of-the-periodontitis-associated-pathogen-selenomonas-sputigena-reveals-previously-not-described-o-glycans-and-rhamnose-fragment-rearrangement-occurring-on-the-glycopeptides
#12
Cornelia B Rath, Falko Schirmeister, Rudolf Figl, Peter H Seeberger, Christina Schaeffer, Daniel Kolarich
Flagellated, Gram-negative, anaerobic, crescent-shaped Selenomonas species are colonizers of the digestive system, where they act at the interface between health and disease. Selenomonas sputigena is also considered a potential human periodontal pathogen, but information on its virulence factors and underlying pathogenicity mechanisms is scarce. Here we provide the first report of a Selenomonas glycoprotein, showing that S. sputigena produces a diversely and heavily O-glycosylated flagellin C9LY14 as a major cellular protein, which carries various hitherto undescribed rhamnose- and N-acetylglucosamine linked O-glycans in the range from mono- to hexasaccharides...
January 16, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29339095/patterning-the-gastrointestinal-epithelium-to-confer-regional-specific-functions
#13
REVIEW
Cayla A Thompson, Ann DeLaForest, Michele A Battle
The gastrointestinal (GI) tract, in simplest terms, can be described as an epithelial-lined muscular tube extending along the cephalocaudal axis from the oral cavity to the anus. Although the general architecture of the GI tract organs is conserved from end to end, the presence of different epithelial tissue structures and unique epithelial cell types within each organ enables each to perform the distinct digestive functions required for efficient nutrient assimilation. Spatiotemporal regulation of signaling pathways and downstream transcription factors controls GI epithelial morphogenesis during development to confer essential regional-specific epithelial structures and functions...
January 12, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29338829/imaging-findings-of-common-opportunistic-infections-and-malignant-tumors-in-acquired-immunodeficiency-syndrome-patients
#14
Ping Li, Juan Li, Hua Dan Xue, Huan Ling Wang, Tai Sheng Li, Zheng Yu Jin
The incidence of human immunodeficiency virus (HIV) infection has gradually increased in recent years.HIV mainly destroys the body's immune system,leading to decreased body resistance and thus the development of a variety of opportunistic infections and neoplastic diseases,especially in the digestive system. However,the clinical manifestations,laboratory findings,and physical examination results of these conditions are not specific. Imaging examinations can determine the presence of infection and tumor lesions and the disease scope;furthermore,they are useful tools for biopsy and follow-up evaluation...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29338690/multimorbidity-patterns-in-the-elderly-a-prospective-cohort-study-with-cluster-analysis
#15
Marina Guisado-Clavero, Albert Roso-Llorach, Tomàs López-Jimenez, Mariona Pons-Vigués, Quintí Foguet-Boreu, Miguel Angel Muñoz, Concepción Violán
BACKGROUND: Multimorbidity is the coexistence of more than two chronic diseases in the same individual; however, there is no consensus about the best definition. In addition, few studies have described the variability of multimorbidity patterns over time. The aim of this study was to identify multimorbidity patterns and their variability over a 6-year period in patients older than 65 years attended in primary health care. METHODS: A cohort study with yearly cross-sectional analysis of electronic health records from 50 primary health care centres in Barcelona...
January 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29338066/endoscopic-scoring-indices-for-evaluation-of-disease-activity-in-ulcerative-colitis
#16
REVIEW
Nadia Mohammed Vashist, Mark Samaan, Mahmoud H Mosli, Claire E Parker, John K MacDonald, Sigrid A Nelson, G Y Zou, Brian G Feagan, Reena Khanna, Vipul Jairath
BACKGROUND: Endoscopic assessment of mucosal disease activity is routinely used to determine eligibility and response to therapy in clinical trials of ulcerative colitis. The operating properties of the existing endoscopic scoring indices are unclear. OBJECTIVES: A systematic review was undertaken to evaluate the development and operating characteristics of endoscopic scoring indices for the evaluation of ulcerative colitis. SEARCH METHODS: We searched MEDLINE, Embase and CENTRAL from inception to 5 July 2016...
January 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29337765/digestive-tract-damage-a-predictor-of-early-surgical-intervention-in-patients-with-newly-diagnosed-crohn-s-disease
#17
Evangelos Messaris
No abstract text is available yet for this article.
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29332228/comparative-evaluation-of-the-aqueous-humor-proteome-of-primary-angle-closure-and-primary-open-angle-glaucomas-and-age-related-cataract-eyes
#18
Inderjeet Kaur, Jasbir Kaur, K Sooraj, Sandeep Goswami, Rohit Saxena, Virander Singh Chauhan, Ramanjit Sihota
PURPOSE: To analyze and compare the total proteome of aqueous humor (AH) from patients having primary angle closure glaucoma (PACG), primary open angle glaucoma (POAG) and age-related cataract. MATERIALS AND METHODOLOGY: Aqueous humor was collected from age-matched PACG, POAG and cataract patients who underwent surgery, and it was immediately stored at - 80 °C until analysis. From each sample, 25 µg of total protein was subjected to trypsin digestion and subsequently LC-MS/MS analysis was performed for the deep proteome analysis...
January 13, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29330905/evidence-based-consensus-on-opportunistic-infections-in-inflammatory-bowel-disease
#19
Jia Ming Qian
Inflammatory bowel disease (IBD), mainly including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic non-specific intestinal disease. The chronic, protracted course of IBD severely affects the patient's quality of life. The treatment of IBD has gone through three phases.
January 12, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29327685/the-role-of-pepsin-in-the-laryngopharyngeal-reflux
#20
Katarzyna Kowalik, Antoni Krzeski
Laryngopharyngeal reflux (LPR) is a common defect among laryngological and phoniatric patients. Although LPR is categorized as a superficial gastroesophageal reflux disease (GERD), differential diagnosis should treat these two diseases separately. LPR symptoms can be assessed in the interview using as a tool the reflux symptom index (RSI). In addition, changes in the larynx that occur during LPR might be seen during laryngoscopy and classified according to the reflux finding score (RFS). One of the main mucosal irritants in LPR is pepsin which digests proteins and impairs the functions of the upper respiratory tract cells by affecting carbonate anhydrase (CAIII) and the Sep 70 protein...
December 30, 2017: Otolaryngologia Polska
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