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https://www.readbyqxmd.com/read/28331888/new-concept-on-an-integrated-interior-magnetic-resonance-imaging-and-medical-linear-accelerator-system-for-radiation-therapy
#1
Xun Jia, Zhen Tian, Yan Xi, Steve B Jiang, Ge Wang
Image guidance plays a critical role in radiotherapy. Currently, cone-beam computed tomography (CBCT) is routinely used in clinics for this purpose. While this modality can provide an attenuation image for therapeutic planning, low soft-tissue contrast affects the delineation of anatomical and pathological features. Efforts have recently been devoted to several MRI linear accelerator (LINAC) projects that lead to the successful combination of a full diagnostic MRI scanner with a radiotherapy machine. We present a new concept for the development of the MRI-LINAC system...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28297573/magnetic-resonance-imaging-guided-delivery-of-neural-stem-cells-into-the-basal-ganglia-of-nonhuman-primates-reveals-a-pulsatile-mode-of-cell-dispersion
#2
Kristen E Malloy, Jinqi Li, Gourav R Choudhury, April Torres, Shruti Gupta, Chris Kantorak, Tim Goble, Peter T Fox, Geoffrey D Clarke, Marcel M Daadi
Optimal stem cell delivery procedures are critical to the success of the cell therapy approach. Variables such as flow rate, suspension solution, needle diameter, cell density, and tissue mechanics affect tissue penetration, backflow along the needle, and the dispersion and survival of injected cells during delivery. Most cell transplantation centers engaged in human clinical trials use custom-designed cannula needles, syringes, or catheters, sometimes precluding the use of magnetic resonance imaging (MRI)-guided delivery to target tissue...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28297284/dosimetric-comparison-of-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-radiotherapy-in-patients-with-prostate-cancer-a-meta-analysis
#3
Wenting Ren, Chao Sun, Ningning Lu, Yingjie Xu, Fei Han, Yue Ping Liu, Jianrong Dai
Intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) are two main radiotherapy techniques. The aim of this study is to explore which is the preferred technique in prostate treatment through the related publications and meta-analysis. Two authors independently identified all relevant articles available regarding eligibility criteria on PubMed, Embase, and Cochrane Library databases until December 2015. Publication bias was evaluated with funnel plot, and statistical analyses were performed with Stata software...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295903/feasibility-of-intraoperative-breast-mri-and-the-role-of-prone-versus-supine-positioning-in-surgical-planning-for-breast-conserving-surgery
#4
Melissa A Mallory, Yasuaki Sagara, Fatih Aydogan, Stephen DeSantis, Jagadeesan Jayender, Diana Caragacianu, Eva Gombos, Kirby G Vosburgh, Ferenc A Jolesz, Mehra Golshan
We assessed the feasibility of supine intraoperative MRI (iMRI) during breast-conserving surgery (BCS), enrolling 15 patients in our phase I trial between 2012 and 2014. Patients received diagnostic prone MRI, BCS, pre-excisional supine iMRI, and postexcisional supine iMRI. Feasibility was assessed based on safety, sterility, duration, and image-quality. Twelve patients completed the study; mean duration = 114 minutes; all images were adequate; no complications, safety, or sterility issues were encountered...
March 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28286276/the-value-of-intraoperative-mri-in-endoscopic-and-microsurgical-transsphenoidal-pituitary-adenoma-resection
#5
Andrej Paľa, Andreas Knoll, Christine Brand, Gwendolin Etzrodt-Walter, Jan Coburger, Christian Rainer Wirtz, Michal Hlaváč
INTRODUCTION: The routine use of iMRI helps to achieve gross total resection in transsphenoidal pituitary surgery. We have compared the added value of iMRI for extent of resection in endoscopic versus microsurgical transsphenoidal adenomectomy. METHODS: A total of 96 patients with pituitary adenoma were included. 28 consecutive patients underwent endoscopic transsphenoidal tumor resection. For comparison, we used a historic cohort of 68 consecutive patients treated microsurgically...
March 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28265818/the-patients-view-impact-of-the-extent-of-resection-intraoperative-imaging-and-awake-surgery-on-health-related-quality-of-life-in-high-grade-glioma-patients-results-of-a-multicenter-cross-sectional-study
#6
Katrin Nickel, Mirjam Renovanz, Jochem König, Linda Stöckelmaier, Anne-Katrin Hickmann, Minou Nadji-Ohl, Jens Engelke, Elke Weimann, Dirk Freudenstein, Oliver Ganslandt, Lars Bullinger, Christian Rainer Wirtz, Jan Coburger
The objective of the present study is to assess the influence of extent of resection (EoR), use of intraoperative imaging, and awake surgery on health-related quality of life (HRQoL) in high-grade glioma (HGG) patients in a prospective multicenter study. We analyzed 170 surgeries of patients suffering from a HGG. During the first year after resection, HRQoL was evaluated using the European Organization of Research and Treatment of Cancer Core Questionnaire C30 and Brain Neoplasm 20 questionnaires. We assessed the influence of EoR; awake surgery; and use of 5-aminolevulinic acid (5-ALA), intraoperative MRI (iMRI), and their combination on sum scores for function and symptoms as well as several neurological single items...
March 6, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28254595/does-low-field-intraoperative-magnetic-resonance-improve-the-results-of-endoscopic-pituitary-surgery-experience-of-the-implementation-of-a-new-device-in-a-referral-center
#7
Sergio García, Luis Reyes, Pedro Roldán, Jorge Torales, Irene Halperin, Felicia Hanzu, Cristobal Langdon, Isam Alobid, Joaquim Enseñat
OBJECTIVE: To assess the contribution of low field intraoperative magnetic resonance(iMRI) to endoscopic pituitary surgery. MATERIALS AND METHODS: The authors analyzed a prospective series of patients undergoing endoscopic endonasal surgery for pituitary macroadenomas assisted with a low field iMRI(PoleStarN30™Medtronic,0,15T). Clinical, radiological and surgical variables were analyzed and compared with our fully endoscopic historic cohort operated without iMRI assistance...
February 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28186470/image-guidance-based-on-mri-for-spinal-interstitial-laser-thermotherapy-technical-aspects-and-accuracy
#8
Claudio E Tatsui, Clarissa N G Nascimento, Dima Suki, Behrang Amini, Jing Li, Amol J Ghia, Jonathan G Thomas, R Jason Stafford, Laurence D Rhines, Juan P Cata, Ashok J Kumar, Ganesh Rao
OBJECTIVE Image guidance for spinal procedures is based on 3D-fluoroscopy or CT, which provide poor visualization of soft tissues, including the spinal cord. To overcome this limitation, the authors developed a method to register intraoperative MRI (iMRI) of the spine into a neuronavigation system, allowing excellent visualization of the spinal cord. This novel technique improved the accuracy in the deployment of laser interstitial thermal therapy probes for the treatment of metastatic spinal cord compression...
February 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28169011/investigation-of-outbreaks-of-pneumocystis-jirovecii-pneumonia-in-two-scottish-renal-units
#9
T Inkster, S Dodd, R Gunson, L Imrie, E Spalding, S Packer, C Deighan, C Daly, J Coia, T Imtiaz, C McGuffie, R Wilson, A M Bal
Pneumocystis jirovecii is recognized as an opportunistic pathogen. In recent years, human-to-human transmission of P. jirovecii has been demonstrated. However, outbreaks of P. jirovecii infections are not well defined because the epidemiological setting that facilitates transmission is not fully understood. This article describes two outbreaks of P. jirovecii pneumonia (PCP) in renal transplant patients in the West of Scotland. In total, 25 patients in two geographically contiguous locations were affected...
November 18, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28124397/nidotherapy-compared-with-enhanced-care-programme-approach-training-for-adults-with-aggressive-challenging-behaviour-and-intellectual-disability-nidabid-cluster-randomised-controlled-trial
#10
P Tyrer, S A Tarabi, P Bassett, N Liedtka, R Hall, J Nagar, A Imrie, H Tyrer
BACKGROUND: Aggressive challenging behaviour is very common in care homes for people with intellectual disability, and better psychological treatments are needed. Nidotherapy aims to change the environment of people with mental illness and is an appropriate treatment for this group of disorders. METHOD: The design was a cluster randomised trial of 20 care homes in which the staff either received training in nidotherapy or the enhanced care programme approach (ECPA), with equivalent duration of treatment in each arm...
January 26, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28108607/insulin-like-growth-factor-binding-protein-1-could-improve-glucose-regulation-and-insulin-sensitivity-through-its-rgd-domain
#11
Natalie J Haywood, Paul A Cordell, Kar Yeun Tang, Natallia Makova, Nadira Y Yuldasheva, Helen Imrie, Hema Viswambharan, Alexander F Bruns, Richard M Cubbon, Mark T Kearney, Stephen B Wheatcroft
Low circulating levels of insulin-like growth factor binding protein 1 (IGFBP-1) are associated with insulin resistance and predict the development of type 2 diabetes. IGFBP-1 can affect cellular functions independently of IGF binding through an Arg-Gly-Asp (RGD) integrin-binding motif. Whether causal mechanisms underlie the favorable association of high IGFBP-1 levels with insulin sensitivity and whether these could be exploited therapeutically remain unexplored. We used recombinant IGFBP-1 and a synthetic RGD-containing hexapeptide in complementary in vitro signaling assays and in vivo metabolic profiling in obese mice to investigate the effects of IGFBP-1 and its RGD domain on insulin sensitivity, insulin secretion, and whole-body glucose regulation...
February 2017: Diabetes
https://www.readbyqxmd.com/read/28059650/surgical-benefits-of-combined-awake-craniotomy-and-intraoperative-magnetic-resonance-imaging-for-gliomas-associated-with-eloquent-areas
#12
Kazuya Motomura, Atsushi Natsume, Kentaro Iijima, Shunichiro Kuramitsu, Masazumi Fujii, Takashi Yamamoto, Satoshi Maesawa, Junko Sugiura, Toshihiko Wakabayashi
OBJECTIVE Maximum extent of resection (EOR) for lower-grade and high-grade gliomas can increase survival rates of patients. However, these infiltrative gliomas are often observed near or within eloquent regions of the brain. Awake surgery is of known benefit for the treatment of gliomas associated with eloquent regions in that brain function can be preserved. On the other hand, intraoperative MRI (iMRI) has been successfully used to maximize the resection of tumors, which can detect small amounts of residual tumors...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28047265/tu-h-bra-05-a-system-design-for-integration-of-an-interior-mri-and-a-linear-accelerator
#13
W Mao, G Wang
PURPOSE: MRI is a highly desirable modality to guide radiation therapy but it is difficult to combine a conventional MRI scanner directly with a linear accelerator (linac). An interior MRI (iMRI) concept has been proposed to acquire MRI images within a small field of view only covering targets and immediate surrounding tissues. The objective of this project is to design an interior MRI system to work with a linac using a magnet to provide a field around 0.2T in a cube of 20cm per side, and perform image reconstruction with a slightly inhomogeneous static magnetic fields...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039341/michael-john-imrie
#14
Tony Nicholson, Alan Wilkinson
No abstract text is available yet for this article.
December 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28008781/impact-of-intraoperative-mri-guided-resection-on-resection-and-survival-in-patient-with-gliomas-a-meta-analysis
#15
Ping Li, Ruobing Qian, Chaoshi Niu, Xianming Fu
OBJECTIVE: This study addressed the benefit of intraoperative magnetic resonance imaging (iMRI) compared with conventional neuronavigation-guided resection in patients with gliomas. RESEARCH DESIGN AND METHODS: The Medline, PubMed, Cochrane, and Google Scholar databases were searched up to 26 September 2015. Randomized controlled trials (RCTs), two-arm prospective studies, and retrospective studies in patients with glioblastoma/glioma who had received surgical treatment were included...
February 2, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27989974/volumetric-analysis-using-low-field-intraoperative-magnetic-resonance-imaging-for-168-newly-diagnosed-supratentorial-glioblastomas-effects-of-extent-of-resection-and-residual-tumor-volume-on-survival-and-recurrence
#16
Atsushi Fukui, Yoshihiro Muragaki, Taiichi Saito, Takashi Maruyama, Masayuki Nitta, Soko Ikuta, Takakazu Kawamata
BACKGROUND: Extent of resection (EOR) remains controversial in therapy for glioblastoma (GBM). However, an increasing number of studies favor maximum EOR as being associated with longer patient survival. Residual tumor volume (RTV) has also recently emerged as a prognostic factor. Low-field intraoperative magnetic resonance imaging (iMRI) has contributed to improve the EOR of GBM. The purpose of this study was to analyze the relationships between EOR/RTV and overall survival (OS)/progression-free survival (PFS) in patients with newly diagnosed GBM using low-field iMRI...
February 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27989902/alternate-update-of-shifted-extended-keyholes-ausek-a-new-accelerating-strategy-for-interventional-mri
#17
Shuai Yu, Derek Kwok, Yufu Zhou, Qing Zhang, Xiaoyan Huang, Geng Li, Bensheng Qiu
Real-time or near-real-time acquisition plays a key role in providing immediate image guidance for interventional magnetic resonance imaging (iMRI). However, the requirement of accurate needle tip localization has made several accelerating techniques, like Keyhole imaging or sliding window reconstruction, difficult to be applied to iMRI. The purpose of this work was to further explore the possible ways of applying view sharing techniques to iMRI. Inspired by Keyhole imaging, we present an easy-to-implement accelerating strategy called "Alternate update of shifted extended keyholes (AUSEK)"...
October 27, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27988033/magnetic-resonance-imaging-and-histology-correlation-in-cushing-s-disease
#18
Václav Masopust, David Netuka, Vladimír Beneš, Martin Májovský, Tomáš Belšán, Ondřej Bradáč, Daniel Hořínek, Mikuláš Kosák, Václav Hána, Michal Kršek
INTRODUCTION: We continuously look for new techniques to improve the radicality of resection and to eliminate the negative effects of surgery. One of the methods that has been implemented in the perioperative management of Cushing's disease was the combination of three magnetic resonance imaging (MRI) sequences: SE, SPGR and fSPGR. MATERIAL AND METHODS: We enrolled 41 patients (11 males, 30 females) diagnosed with Cushing's disease. A 3D tumour model with a navigation console was developed using each SPGR, fSPGR and SE sequence...
November 2, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27934913/erratum-charge-density-waves-in-disordered-media-circumventing-the-imry-ma-argument
#19
Hitesh J Changlani, Norm M Tubman, Taylor L Hughes
No abstract text is available yet for this article.
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929498/dosimetric-comparison-of-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-radiotherapy-in-patients-with-prostate-cancer-a-meta-analysis
#20
Wenting Ren, Chao Sun, Ningning Lu, Yingjie Xu, Fei Han, Yue Ping Liu, Jianrong Dai
Intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) are two main radiotherapy techniques. The aim of this study is to explore which is the preferred technique in prostate treatment through the related publica-tions and meta-analysis. Two authors independently identified all relevant articles available regarding eligibility criteria on PubMed, Embase, and Cochrane Library databases until December 2015. Publication bias was evaluated with funnel plot, and statistical analyses were performed with Stata software...
November 8, 2016: Journal of Applied Clinical Medical Physics
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