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Nebras M Warsi, Oliver Lasry, Adel Farah, Christine Saint-Martin, Jose L Montes, Jeffrey Atkinson, Jean-Pierre Farmer, Roy W R Dudley
PURPOSE: Three-tesla intraoperative MRI (iMRI) is a promising tool that could help confirm complete resections and disconnections in pediatric epilepsy surgery, leading to improved outcomes. However, a large proportion of epileptogenic pathologies in children are poorly defined on imaging, which brings into question the utility of iMRI for these cases. Our aim was to compare postoperative seizure outcomes between iMRI- and non-iMRI-based epilepsy surgeries. METHODS: We performed a comparative retrospective analysis of non-iMRI- versus iMRI-based epilepsy surgeries with 2-year follow-up...
October 18, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Pedro Roldán, Sergio García, Josep González, Luis Alberto Reyes, Jorge Torales, Ricard Valero, Laura Oleaga, Joaquim Enseñat
OBJECTIVES: Intra-operative magnetic resonance imaging (iMRI) is a recently introduced tool in the most advanced neurosurgical operating rooms worldwide. We present our preliminary experience in brain tumour surgery with low field PoleStar N30® intraoperative MRI since its introduction in 2013 in the Barcelona Clinic Hospital. MATERIAL AND METHODS: A prospective non-randomised study was conducted on cases operated on using iMRI and intention of complete removal up to October 2015...
October 14, 2016: Neurocirugía
A Prica, F Baldassarre, L K Hicks, K Imrie, T Kouroukis, M Cheung
Rituximab is the first monoclonal antibody to be approved for use by the US Food and Drug Administration in cancer. Its role in the treatment of non-Hodgkin lymphoma, including chronic lymphocytic leukaemia (CLL), has evolved significantly. We aimed to systematically review and update the literature on rituximab in lymphoma and CLL, and provide evidence-based consensus guidelines for its rational use. Validated methodology from the Cancer Care Ontario Program in Evidence-based Care was used. A comprehensive literature search was completed by a methodologist from the Hematology Disease Site Group of Cancer Care Ontario...
October 13, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Mario Giordano, Cinta Arraez, Amir Samii, Madjid Samii, Concezio Di Rocco
INTRODUCTION: The treatment of low-grade gliomas (LGGs) in pediatric age is still controversial. However, most authors report longer life expectancy in case of completely removed cerebral gliomas. Intraoperative magnetic resonance imaging (iMRI) is increasingly utilized in the surgical management of intra-axial tumor in adults following the demonstration of its effectiveness. In this article, we analyze the management of LGG using iMRI focusing on its impact on resection rate and its limits in the pediatric population...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Chen Li-Feng, Yang Yang, Ma Xiao-Dong, Yu Xin-Guang, Gui Qiu-Ping, Xu Bai-Nan, Zhou Ding-Biao
AIM: The author evaluated the impact of high-field intraoperative MRI (iMRI) and functional neuronavigation on insular high-grade glioma(HGG) surgery. MATERIAL AND METHODS: Between 2010 and 2014, 51 insular HGG patients underwent operations guided by combined high-field iMRI and functional neuronavigation.22 insular HGG patients underwent conventional neuronavigation operations were assessed as the control group. Tumor volumetric scan analysis, Karnofsky performance score (KPS) and follow-up results were reviewed retrospectively...
August 23, 2016: Turkish Neurosurgery
Scott C Vermilyea, Jianfeng Lu, Miles Olsen, Scott Guthrie, Yunlong Tao, Eva M Fekete, Marissa K Riedel, Kevin Brunner, Carissa Boettcher, Viktorya Bondarenko, Ethan Brodsky, Walter F Block, Andrew Alexander, Su-Chun Zhang, Marina E Emborg
Induced pluripotent stem cell (iPSC)-derived neurons represent an opportunity for cell replacement strategies for neurodegenerative disorders such as Parkinson's disease (PD). Improvement in cell graft targeting, distribution and density can be key for disease modification. We have previously developed a trajectory guide system for Real-Time Intraoperative Magnetic Resonance Imaging (RT-IMRI) delivery of infusates, such as viral vector suspensions for gene therapy strategies. Intracerebral delivery of iPSCderived neurons presents different challenges than viral vectors, including limited cell survival if cells are kept at room temperature for prolonged periods of time, precipitation and aggregation of cells in the cannula and obstruction during injection, which must be solved for successful application of this delivery approach...
September 14, 2016: Cell Transplantation
C A Waterman, P Batstone, N Bown, L Cresswell, C Delmege, C J English, G Fews, L Grimsley, S Imrie, A Kulkarni, K Mann, R Johnson, S M Morgan, P Roberts, I Simonic, S Trueman, M Wall, D McMullan
OBJECTIVE: To map the current testing being undertaken following pregnancy loss across the UK and to examine the clinical utility in terms of identifying a cause for the loss and in identifying couples at risk of an unbalanced liveborn child. DESIGN: Retrospective audit. SETTING: UK, for the year 2014. POPULATION: An audit of 6465 referrals for genetic testing of tissue samples following pregnancy loss. METHODS: Data were obtained by questionnaire from 15 UK regional genetics laboratories...
September 5, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Hooman Azmi, Fiona Gupta, Mario Vukic, Jason Kreitner, Elizabeth Kera, Gregory Nicola, Sean Pierce, David Panush, Randy Cohen
BACKGROUND: Interventional magnetic resonance imaging (iMRI) guided deep brain stimulation (DBS) for Parkinson's disease (PD) has been shown to be effective. The costs of a dedicated intraoperative MRI may be prohibitive. The procedure can also be performed in a diagnostic scanner, however this presents challenges for utilization of time when the scanner is used both as a diagnostic and an interventional unit. This report outlines our novel methodology for patient selection for implantation in a diagnostic MR scanner, as an attempt to streamline the use of resources...
2016: Surgical Neurology International
Hitesh J Changlani, Norm M Tubman, Taylor L Hughes
Two powerful theoretical predictions, Anderson localization and the Imry-Ma argument, impose significant restrictions on the phases of matter that can exist in the presence of even the smallest amount of disorder in one-dimensional systems. These predictions forbid electrically conducting states and ordered states respectively. It was thus remarkable that a mechanism to circumvent Anderson localization relying on the presence of correlated disorder was found, that is also realized in certain biomolecular systems...
2016: Scientific Reports
Melissa Phuphanich, Maneerat Rattanamahattana, Anchalee Avihingsanon, Ploenchan Chetchotisakd, Opass Putcharoen, Monica Gandhi, Annette H Sohn, John Imrie, Praphan Phanuphak, Stephen J Kerr
OBJECTIVES: Excellent adherence to combination antiretroviral therapy can suppress HIV replication and produce life expectancies nearing those of individuals without HIV infection. This qualitative study sought to identify the barriers and facilitators to good antiretroviral medication adherence in Thai patients living with HIV. METHODS: Semi-structured interviews were conducted with a convenience sample (n=21) of patients attending routine clinic visits at Srinagarind Hospital in Khon Kaen, or HIV-NAT, the Thai Red Cross AIDS Research Centre in Bangkok...
2016: Journal of Virus Eradication
Mercedes Pineda, Eugen Mengel, Helena Jahnová, Bénédicte Héron, Jackie Imrie, Charles M Lourenço, Vanessa van der Linden, Parvaneh Karimzadeh, Vassili Valayannopoulos, Pavel Jesina, Juan V Torres, Stefan A Kolb
BACKGROUND: Niemann-Pick disease Type C (NP-C) is difficult to diagnose due to heterogeneous and nonspecific clinical presentation. The NP-C Suspicion Index (SI) was developed to identify patients with a high likelihood of NP-C; however, it was less reliable in patients aged <4 years. METHODS: An early-onset NP-C SI was constructed following retrospective chart review of symptom presentation in 200 patients from nine centres comprised of 106 NP-C cases, 31 non-cases and 63 controls...
2016: BMC Pediatrics
Daniel A Paterson, Min Gao, Young-Ki Kim, Afsoon Jamali, Kirsten L Finley, Beatriz Robles-Hernández, Sergio Diez-Berart, Josep Salud, M Rosario de la Fuente, Bakir A Timimi, Herbert Zimmermann, Cristina Greco, Alberta Ferrarini, John M D Storey, David O López, Oleg D Lavrentovich, Geoffrey R Luckhurst, Corrie T Imrie
The synthesis and characterisation of the nonsymmetric liquid crystal dimer, 1-(4-cyanobiphenyl-4'-yloxy)-6-(4-cyanobiphenyl-4'-yl)hexane (CB6OCB) is reported. An enantiotropic nematic (N)-twist-bend nematic (NTB) phase transition is observed at 109 °C and a nematic-isotropic phase transition at 153 °C. The NTB phase assignment has been confirmed using polarised light microscopy, freeze fracture transmission electron microscopy (FFTEM), (2)H-NMR spectroscopy, and X-ray diffraction. The effective molecular length in both the NTB and N phases indicates a locally intercalated arrangement of the molecules, and the helicoidal pitch length in the NTB phase is estimated to be 8...
August 10, 2016: Soft Matter
Seyed Amirhossein Javadi, Arya Nabavi, Mario Giordano, Elham Faghihzadeh, Amir Samii
BACKGROUND: The accuracy of intraoperative diffusion tensor imaging (DTI)-based tractography of the corticospinal tract (CST) is crucial for its use in neurosurgical planning and its implementation in image-guided surgery. To the best of our knowledge, this is the largest prospective study of the intraoperative direct electrical subcortical stimulation (DESS) of the CST with intraoperative DTI tractography of the CST, with application of intraoperative magnetic resonance imaging (iMRI)...
July 13, 2016: Neurosurgery
Joanna Orne-Gliemann, Thembelihle Zuma, Jeremiah Chikovore, Natasha Gillespie, Merridy Grant, Collins Iwuji, Joseph Larmarange, Nuala McGrath, France Lert, John Imrie
In the context of the ANRS 12249 Treatment as Prevention (TasP) trial, we investigated perceptions of regular and repeat HIV-testing in rural KwaZulu-Natal (South Africa), an area of very high HIV prevalence and incidence. We conducted two qualitative studies, before (2010) and during the early implementation stages of the trial (2013-2014), to appreciate the evolution in community perceptions of repeat HIV-testing over this period of rapid changes in HIV-testing and treatment approaches. Repeated focus group discussions were organized with young adults, older adults and mixed groups...
2016: AIDS Care
Harapan Harapan, Samsul Anwar, Aslam Bustaman, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Rovy Pratama, Jonny Karunia Fajar, Abdul Malik Setiawan, Allison Imrie, Ulrich Kuch, David Alexander Groneberg, R Tedjo Sasmono, Meghnath Dhimal, Ruth Müller
BACKGROUND: Dengue virus infection is the most rapidly spreading vector-borne disease in the world. Essential research on dengue virus transmission and its prevention requires community participation. Therefore, it is crucial to understand the factors that are associated with the willingness of communities in high prevalence areas to participate in dengue research. The aim of this study was to explore factors associated with the willingness of healthy community members in Aceh province, Indonesia, to participate in dengue research that would require phlebotomy...
2016: PloS One
Chima Oluigbo, Matthew Sacino, John S Myseros, Suresh N Magge, William Gaillard, Robert F Keating
INTRODUCTION: Focal cortical dysplasia (FCD) is a common cause of intractable epilepsy in children. Seizure freedom following resection of FCD is determined by complete resection of the dysplastic cortical tissue. However, difficulty with intraoperative identification of the FCD lesion may limit the ability to achieve the surgical objective of complete extirpation of these lesions. The use of intraoperative magnetic resonance imaging (iMRI) may aid in real-time detection of these lesions and improve seizure control outcomes compared with traditional resective surgery...
August 2016: Neurosurgery
Christine Jungk, Moritz Scherer, Andreas Mock, David Capper, Alexander Radbruch, Andreas von Deimling, Martin Bendszus, Christel Herold-Mende, Andreas Unterberg
Current evidence supports a maximized extent of resection (EOR) in low-grade gliomas (LGG), regardless of different histological subtypes and molecular markers. We therefore evaluated the prognostic impact of extensive, mainly intraoperative (i)MRI-guided surgery in low-grade astrocytomas stratified for IDH1 mutation status. Retrospective assessment of 46 consecutive cases of newly diagnosed supratentorial WHO grade II astrocytomas treated during the last decade was performed. IDH1 mutation status was obtained for all patients...
September 2016: Journal of Neuro-oncology
Ramsey Ashour, Stephen Reintjes, Michael S Park, Sananthan Sivakanthan, Harry van Loveren, Siviero Agazzi
BACKGROUND: Although intraoperative magnetic resonance imaging (iMRI) increasingly is used during glioma resection, its role in skull base surgery has not been well documented. In this study, we evaluate our experience with iMRI for skull base surgery. METHODS: Medical records were reviewed retrospectively on all neurosurgical cases performed at our institution in the IMRIS iMRI suite between April 2014 and July 2015. RESULTS: During the study period, the iMRI suite was used for 71 skull base tumors...
September 2016: World Neurosurgery
Rodrigo Castellanos Caro, Maria Cristina Dos Santos
Graphene nanoribbons with well defined edges have been shown to possess high conductivities and behave like a quantum wire. Methods from synthetic organic chemistry have successfully been applied to produce such nanoribbons with smooth and chemically stable edges by saturation with hydrogen. Herein, we present ab initio calculations in a family of molecules related to the thinnest graphene nanoribbon, substitutionally doped with sulfur, for which synthetic methods are available. We show that sulfur doping can suppress the polyradical nature of these molecules...
June 28, 2016: Physical Chemistry Chemical Physics: PCCP
Rachel Pruitt, Alexander Gamble, Karen Black, Michael Schulder, Ashesh D Mehta
OBJECTIVE Complications of laser interstitial thermal therapy (LITT) are underreported. The authors discuss how they have modified their technique in the context of technical and treatment-related adverse events. METHODS The Medtronic Visualase system was used in 49 procedures in 46 patients. Between 1 and 3 cooling catheters/laser fiber assemblies were placed, for a total of 62 implanted devices. Devices were placed using frameless stereotaxy (n = 3), frameless stereotaxy with intraoperative MRI (iMRI) (n = 9), iMRI under direct vision (n = 2), MRI alone (n = 1), or frame-based (n = 47) techniques...
June 3, 2016: Journal of Neurosurgery
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