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https://www.readbyqxmd.com/read/28186470/image-guidance-based-on-mri-for-spinal-interstitial-laser-thermotherapy-technical-aspects-and-accuracy
#1
Claudio E Tatsui, Clarissa N G Nascimento, Dima Suki, Behrang Amini, Jing Li, Amol J Ghia, Jonathan G Thomas, R Jason Stafford, Laurence D Rhines, Juan P Cata, Ashok J Kumar, Ganesh Rao
OBJECTIVE Image guidance for spinal procedures is based on 3D-fluoroscopy or CT, which provide poor visualization of soft tissues, including the spinal cord. To overcome this limitation, the authors developed a method to register intraoperative MRI (iMRI) of the spine into a neuronavigation system, allowing excellent visualization of the spinal cord. This novel technique improved the accuracy in the deployment of laser interstitial thermal therapy probes for the treatment of metastatic spinal cord compression...
February 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28169011/investigation-of-outbreaks-of-pneumocystis-jirovecii-pneumonia-in-two-scottish-renal-units
#2
T Inkster, S Dodd, R Gunson, L Imrie, E Spalding, S Packer, C Deighan, C Daly, J Coia, T Imtiaz, C McGuffie, R Wilson, A M Bal
Pneumocystis jirovecii is recognized as an opportunistic pathogen. In recent years, human-to-human transmission of P. jirovecii has been demonstrated. However, outbreaks of P. jirovecii infections are not well defined because the epidemiological setting that facilitates transmission is not fully understood. This article describes two outbreaks of P. jirovecii pneumonia (PCP) in renal transplant patients in the West of Scotland. In total, 25 patients in two geographically contiguous locations were affected...
November 18, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28124397/nidotherapy-compared-with-enhanced-care-programme-approach-training-for-adults-with-aggressive-challenging-behaviour-and-intellectual-disability-nidabid-cluster-randomised-controlled-trial
#3
P Tyrer, S A Tarabi, P Bassett, N Liedtka, R Hall, J Nagar, A Imrie, H Tyrer
BACKGROUND: Aggressive challenging behaviour is very common in care homes for people with intellectual disability, and better psychological treatments are needed. Nidotherapy aims to change the environment of people with mental illness and is an appropriate treatment for this group of disorders. METHOD: The design was a cluster randomised trial of 20 care homes in which the staff either received training in nidotherapy or the enhanced care programme approach (ECPA), with equivalent duration of treatment in each arm...
January 26, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28108607/insulin-like-growth-factor-binding-protein-1-could-improve-glucose-regulation-and-insulin-sensitivity-through-its-rgd-domain
#4
Natalie J Haywood, Paul A Cordell, Kar Yeun Tang, Natallia Makova, Nadira Y Yuldasheva, Helen Imrie, Hema Viswambharan, Alexander F Bruns, Richard M Cubbon, Mark T Kearney, Stephen B Wheatcroft
Low circulating levels of insulin-like growth factor binding protein 1 (IGFBP-1) are associated with insulin resistance and predict the development of type 2 diabetes. IGFBP-1 can affect cellular functions independently of IGF binding through an Arg-Gly-Asp (RGD) integrin-binding motif. Whether causal mechanisms underlie the favorable association of high IGFBP-1 levels with insulin sensitivity and whether these could be exploited therapeutically remain unexplored. We used recombinant IGFBP-1 and a synthetic RGD-containing hexapeptide in complementary in vitro signaling assays and in vivo metabolic profiling in obese mice to investigate the effects of IGFBP-1 and its RGD domain on insulin sensitivity, insulin secretion, and whole-body glucose regulation...
February 2017: Diabetes
https://www.readbyqxmd.com/read/28059650/surgical-benefits-of-combined-awake-craniotomy-and-intraoperative-magnetic-resonance-imaging-for-gliomas-associated-with-eloquent-areas
#5
Kazuya Motomura, Atsushi Natsume, Kentaro Iijima, Shunichiro Kuramitsu, Masazumi Fujii, Takashi Yamamoto, Satoshi Maesawa, Junko Sugiura, Toshihiko Wakabayashi
OBJECTIVE Maximum extent of resection (EOR) for lower-grade and high-grade gliomas can increase survival rates of patients. However, these infiltrative gliomas are often observed near or within eloquent regions of the brain. Awake surgery is of known benefit for the treatment of gliomas associated with eloquent regions in that brain function can be preserved. On the other hand, intraoperative MRI (iMRI) has been successfully used to maximize the resection of tumors, which can detect small amounts of residual tumors...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28047265/tu-h-bra-05-a-system-design-for-integration-of-an-interior-mri-and-a-linear-accelerator
#6
W Mao, G Wang
PURPOSE: MRI is a highly desirable modality to guide radiation therapy but it is difficult to combine a conventional MRI scanner directly with a linear accelerator (linac). An interior MRI (iMRI) concept has been proposed to acquire MRI images within a small field of view only covering targets and immediate surrounding tissues. The objective of this project is to design an interior MRI system to work with a linac using a magnet to provide a field around 0.2T in a cube of 20cm per side, and perform image reconstruction with a slightly inhomogeneous static magnetic fields...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039341/michael-john-imrie
#7
Tony Nicholson, Alan Wilkinson
No abstract text is available yet for this article.
December 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28008781/impact-of-intraoperative-mri-guided-resection-on-resection-and-survival-in-patient-with-gliomas-a-meta-analysis
#8
Ping Li, Ruobing Qian, Chaoshi Niu, Xianming Fu
OBJECTIVE: This study addressed the benefit of intraoperative magnetic resonance imaging (iMRI) compared with conventional neuronavigation-guided resection in patients with gliomas. RESEARCH DESIGN AND METHODS: The Medline, PubMed, Cochrane, Google Scholar databases were searched until September 26th, 2015 Randomized controlled trials (RCTs), two-arm prospective studies, retrospective studies in patients with glioblastoma/glioma who had received surgical treatment were included...
December 23, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27989974/volumetric-analysis-using-low-field-intraoperative-magnetic-resonance-imaging-for-168-newly-diagnosed-supratentorial-glioblastomas-effects-of-extent-of-resection-and-residual-tumor-volume-on-survival-and-recurrence
#9
Atsushi Fukui, Yoshihiro Muragaki, Taiichi Saito, Takashi Maruyama, Masayuki Nitta, Soko Ikuta, Takakazu Kawamata
BACKGROUND: Extent of resection (EOR) remains controversial in therapy for glioblastoma (GBM). However, an increasing number of studies favor maximum EOR as being associated with longer patient survival. Residual tumor volume (RTV) has also recently emerged as a prognostic factor. Low-field intraoperative magnetic resonance imaging (iMRI) has contributed to improve the EOR of GBM. The purpose of this study was to analyze the relationships between EOR/RTV and overall survival (OS)/progression-free survival (PFS) in patients with newly diagnosed GBM using low-field iMRI...
October 28, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27989902/alternate-update-of-shifted-extended-keyholes-ausek-a-new-accelerating-strategy-for-interventional-mri
#10
Shuai Yu, Derek Kwok, Yufu Zhou, Qing Zhang, Xiaoyan Huang, Geng Li, Bensheng Qiu
Real-time or near-real-time acquisition plays a key role in providing immediate image guidance for interventional magnetic resonance imaging (iMRI). However, the requirement of accurate needle tip localization has made several accelerating techniques, like Keyhole imaging or sliding window reconstruction, difficult to be applied to iMRI. The purpose of this work was to further explore the possible ways of applying view sharing techniques to iMRI. Inspired by Keyhole imaging, we present an easy-to-implement accelerating strategy called "Alternate update of shifted extended keyholes (AUSEK)"...
October 27, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27988033/magnetic-resonance-imaging-and-histology-correlation-in-cushing-s-disease
#11
Václav Masopust, David Netuka, Vladimír Beneš, Martin Májovský, Tomáš Belšán, Ondřej Bradáč, Daniel Hořínek, Mikuláš Kosák, Václav Hána, Michal Kršek
INTRODUCTION: We continuously look for new techniques to improve the radicality of resection and to eliminate the negative effects of surgery. One of the methods that has been implemented in the perioperative management of Cushing's disease was the combination of three magnetic resonance imaging (MRI) sequences: SE, SPGR and fSPGR. MATERIAL AND METHODS: We enrolled 41 patients (11 males, 30 females) diagnosed with Cushing's disease. A 3D tumour model with a navigation console was developed using each SPGR, fSPGR and SE sequence...
November 2, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27934913/erratum-charge-density-waves-in-disordered-media-circumventing-the-imry-ma-argument
#12
Hitesh J Changlani, Norm M Tubman, Taylor L Hughes
No abstract text is available yet for this article.
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929498/dosimetric-comparison-of-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-radiotherapy-in-patients-with-prostate-cancer-a-meta-analysis
#13
Wenting Ren, Chao Sun, Ningning Lu, Yingjie Xu, Fei Han, Yue Ping Liu, Jianrong Dai
Intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) are two main radiotherapy techniques. The aim of this study is to explore which is the preferred technique in prostate treatment through the related publica-tions and meta-analysis. Two authors independently identified all relevant articles available regarding eligibility criteria on PubMed, Embase, and Cochrane Library databases until December 2015. Publication bias was evaluated with funnel plot, and statistical analyses were performed with Stata software...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27920123/selective-enhancement-of-insulin-sensitivity-in-the-endothelium-in-vivo-reveals-a-novel-proatherosclerotic-signalling-loop
#14
Hema Viswambharan, Nadira Y Yuldasheva, Anshuman Sengupta, Helen Imrie, Matthew C Gage, Natalie J Haywood, Andrew M Walker, Anna Skromna, Natalia Makova, Stacey L Galloway, Pooja Shah, Piruthivi Sukumar, Karen E Porter, Peter J Grant, Ajay M Shah, Celio X Santos, Jing Li, David J Beech, Stephen Wheatcroft, Richard M Cubbon, Mark T Kearney
RATIONALE: In the endothelium, insulin stimulates endothelial nitric oxide synthase (eNOS) to generate the anti-atherosclerotic signalling radical NO. Insulin resistant type 2 diabetes is associated with reduced NO availability and accelerated atherosclerosis. The effect of enhancing endothelial insulin sensitivity on NO availability is unclear. OBJECTIVE: To answer this question we generated a mouse with endothelial cell (EC)-specific over-expression of the human insulin receptor (hIRECO) using the Tie2 promoter-enhancer...
December 5, 2016: Circulation Research
https://www.readbyqxmd.com/read/27908746/willingness-to-pay-for-a-dengue-vaccine-and-its-associated-determinants-in-indonesia-a-community-based-cross-sectional-survey-in-aceh
#15
Harapan Harapan, Samsul Anwar, Aslam Bustamam, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Mahmuda Mahmuda, Mudatsir Mudatsir, Allison Imrie, R Tedjo Sasmono, Ulrich Kuch, Ziv Shkedy, Setia Pramana
Vaccination strategies are being considered as a part of dengue prevention programs in endemic countries. To accelerate the introduction of dengue vaccine into the public sector program and private markets, understanding the private economic benefits of a dengue vaccine is therefore essential. The aim of this study was to assess the willingness to pay (WTP) for a dengue vaccine among community members in Indonesia and its associated explanatory variables. A community-based, cross-sectional survey was conducted in nine regencies of Aceh province, Indonesia, from November 2014 to March 2015...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27834621/repeat-surgery-for-focal-cortical-dysplasias-in-children-indications-and-outcomes
#16
Matthew F Sacino, Cheng-Ying Ho, Matthew T Whitehead, Amy Kao, Dewi Depositario-Cabacar, John S Myseros, Suresh N Magge, Robert F Keating, William D Gaillard, Chima O Oluigbo
OBJECTIVE Focal cortical dysplasia (FCD) is a common cause of medically intractable epilepsy that often may be treated by surgery. Following resection, many patients continue to experience seizures, necessitating a decision for further surgery to achieve the desired seizure outcomes. Few studies exist on the efficacy of reoperation for intractable epilepsy due to FCD in pediatric cohorts, including the definition of prognostic factors correlated with clinical benefit from further resection. METHODS The authors retrospectively analyzed the medical records and MR images of 22 consecutive pediatric patients who underwent repeat FCD resection after unsuccessful first surgery at the Children's National Health System between March 2005 and April 2015...
February 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27807135/electrically-tunable-laser-based-on-oblique-heliconical-cholesteric-liquid-crystal
#17
Jie Xiang, Andrii Varanytsia, Fred Minkowski, Daniel A Paterson, John M D Storey, Corrie T Imrie, Oleg D Lavrentovich, Peter Palffy-Muhoray
A cholesteric liquid crystal (CLC) formed by chiral molecules represents a self-assembled one-dimensionally periodic helical structure with pitch [Formula: see text] in the submicrometer and micrometer range. Because of the spatial periodicity of the dielectric permittivity, a CLC doped with a fluorescent dye and pumped optically is capable of mirrorless lasing. An attractive feature of a CLC laser is that the pitch [Formula: see text] and thus the wavelength of lasing [Formula: see text] can be tuned, for example, by chemical composition...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27798374/magnetic-resonance-imaging-guided-delivery-of-neural-stem-cells-into-the-basal-ganglia-of-nonhuman-primates-reveals-a-pulsatile-mode-of-cell-dispersion
#18
Kristen E Malloy, Jinqi Li, Gourav R Choudhury, April Torres, Shruti Gupta, Chris Kantorak, Tim Goble, Peter T Fox, Geoffrey D Clarke, Marcel M Daadi
: : Optimal stem cell delivery procedures are critical to the success of the cell therapy approach. Variables such as flow rate, suspension solution, needle diameter, cell density, and tissue mechanics affect tissue penetration, backflow along the needle, and the dispersion and survival of injected cells during delivery. Most cell transplantation centers engaged in human clinical trials use custom-designed cannula needles, syringes, or catheters, sometimes precluding the use of magnetic resonance imaging (MRI)-guided delivery to target tissue...
October 18, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27791707/intraoperative-magnetic-resonance-imaging-in-pediatric-neurosurgery-safety-and-utility
#19
Mario Giordano, Amir Samii, Anna C Lawson McLean, Helmut Bertalanffy, Rudolf Fahlbusch, Madjid Samii, Concezio Di Rocco
OBJECTIVE The use of high-field intraoperative MRI has been largely studied for the treatment of intracranial tumors in adult patients. In this study, the authors investigated the safety, advantages, and limitations of high-field iMRI for cranial neurosurgical procedures in pediatric patients, with particular attention to craniopharyngiomas and gliomas. METHODS The authors performed 82 surgical procedures in patients under 16 years of age (range 0.8-15 years) over an 8-year period (2007-2014) using iMRI. The population was divided into 3 groups based on the condition treated: sellar region tumors (Group 1), gliomas (Group 2), and other pathological entities (Group 3)...
January 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27757571/3-t-intraoperative-mri-imri-for-pediatric-epilepsy-surgery
#20
Nebras M Warsi, Oliver Lasry, Adel Farah, Christine Saint-Martin, Jose L Montes, Jeffrey Atkinson, Jean-Pierre Farmer, Roy W R Dudley
PURPOSE: Three-tesla intraoperative MRI (iMRI) is a promising tool that could help confirm complete resections and disconnections in pediatric epilepsy surgery, leading to improved outcomes. However, a large proportion of epileptogenic pathologies in children are poorly defined on imaging, which brings into question the utility of iMRI for these cases. Our aim was to compare postoperative seizure outcomes between iMRI- and non-iMRI-based epilepsy surgeries. METHODS: We performed a comparative retrospective analysis of non-iMRI- versus iMRI-based epilepsy surgeries with 2-year follow-up...
December 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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