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https://www.readbyqxmd.com/read/27908746/willingness-to-pay-for-a-dengue-vaccine-and-its-associated-determinants-in-indonesia-a-community-based-cross-sectional-survey-in-aceh
#1
Harapan Harapan, Samsul Anwar, Aslam Bustaman, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Mahmuda Mahmuda, Mudatsir Mudatsir, Allison Imrie, R Tedjo Sasmono, Ulrich Kuch, Ziv Shkedy, Setia Pramana
Vaccination strategies are being considered as a part of dengue prevention programs in endemic countries. To accelerate the introduction of dengue vaccine into the public sector program and private markets, understanding the private economic benefits of a dengue vaccine is therefore essential. The aim of this study was to assess the willingness to pay (WTP) for a dengue vaccine among community members in Indonesia and its associated explanatory variables. A community-based, cross-sectional survey was conducted in nine regencies of Aceh province, Indonesia, from November 2014 to March 2015...
November 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27834621/repeat-surgery-for-focal-cortical-dysplasias-in-children-indications-and-outcomes
#2
Matthew F Sacino, Cheng-Ying Ho, Matthew T Whitehead, Amy Kao, Dewi Depositario-Cabacar, John S Myseros, Suresh N Magge, Robert F Keating, William D Gaillard, Chima O Oluigbo
OBJECTIVE Focal cortical dysplasia (FCD) is a common cause of medically intractable epilepsy that often may be treated by surgery. Following resection, many patients continue to experience seizures, necessitating a decision for further surgery to achieve the desired seizure outcomes. Few studies exist on the efficacy of reoperation for intractable epilepsy due to FCD in pediatric cohorts, including the definition of prognostic factors correlated with clinical benefit from further resection. METHODS The authors retrospectively analyzed the medical records and MR images of 22 consecutive pediatric patients who underwent repeat FCD resection after unsuccessful first surgery at the Children's National Health System between March 2005 and April 2015...
November 11, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27807135/electrically-tunable-laser-based-on-oblique-heliconical-cholesteric-liquid-crystal
#3
Jie Xiang, Andrii Varanytsia, Fred Minkowski, Daniel A Paterson, John M D Storey, Corrie T Imrie, Oleg D Lavrentovich, Peter Palffy-Muhoray
A cholesteric liquid crystal (CLC) formed by chiral molecules represents a self-assembled one-dimensionally periodic helical structure with pitch [Formula: see text] in the submicrometer and micrometer range. Because of the spatial periodicity of the dielectric permittivity, a CLC doped with a fluorescent dye and pumped optically is capable of mirrorless lasing. An attractive feature of a CLC laser is that the pitch [Formula: see text] and thus the wavelength of lasing [Formula: see text] can be tuned, for example, by chemical composition...
November 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27798374/magnetic-resonance-imaging-guided-delivery-of-neural-stem-cells-into-the-basal-ganglia-of-nonhuman-primates-reveals-a-pulsatile-mode-of-cell-dispersion
#4
Kristen E Malloy, Jinqi Li, Gourav R Choudhury, April Torres, Shruti Gupta, Chris Kantorak, Tim Goble, Peter T Fox, Geoffrey D Clarke, Marcel M Daadi
: : Optimal stem cell delivery procedures are critical to the success of the cell therapy approach. Variables such as flow rate, suspension solution, needle diameter, cell density, and tissue mechanics affect tissue penetration, backflow along the needle, and the dispersion and survival of injected cells during delivery. Most cell transplantation centers engaged in human clinical trials use custom-designed cannula needles, syringes, or catheters, sometimes precluding the use of magnetic resonance imaging (MRI)-guided delivery to target tissue...
October 18, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27791707/intraoperative-magnetic-resonance-imaging-in-pediatric-neurosurgery-safety-and-utility
#5
Mario Giordano, Amir Samii, Anna C Lawson McLean, Helmut Bertalanffy, Rudolf Fahlbusch, Madjid Samii, Concezio Di Rocco
OBJECTIVE The use of high-field intraoperative MRI has been largely studied for the treatment of intracranial tumors in adult patients. In this study, the authors investigated the safety, advantages, and limitations of high-field iMRI for cranial neurosurgical procedures in pediatric patients, with particular attention to craniopharyngiomas and gliomas. METHODS The authors performed 82 surgical procedures in patients under 16 years of age (range 0.8-15 years) over an 8-year period (2007-2014) using iMRI. The population was divided into 3 groups based on the condition treated: sellar region tumors (Group 1), gliomas (Group 2), and other pathological entities (Group 3)...
October 28, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27757571/3-t-intraoperative-mri-imri-for-pediatric-epilepsy-surgery
#6
Nebras M Warsi, Oliver Lasry, Adel Farah, Christine Saint-Martin, Jose L Montes, Jeffrey Atkinson, Jean-Pierre Farmer, Roy W R Dudley
PURPOSE: Three-tesla intraoperative MRI (iMRI) is a promising tool that could help confirm complete resections and disconnections in pediatric epilepsy surgery, leading to improved outcomes. However, a large proportion of epileptogenic pathologies in children are poorly defined on imaging, which brings into question the utility of iMRI for these cases. Our aim was to compare postoperative seizure outcomes between iMRI- and non-iMRI-based epilepsy surgeries. METHODS: We performed a comparative retrospective analysis of non-iMRI- versus iMRI-based epilepsy surgeries with 2-year follow-up...
December 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27751711/-low-field-intra-operative-magnetic-resonance-imaging-for-brain-tumour-surgery-preliminary-experience
#7
Pedro Roldán, Sergio García, Josep González, Luis Alberto Reyes, Jorge Torales, Ricard Valero, Laura Oleaga, Joaquim Enseñat
OBJECTIVES: Intra-operative magnetic resonance imaging (iMRI) is a recently introduced tool in the most advanced neurosurgical operating rooms worldwide. We present our preliminary experience in brain tumour surgery with low field PoleStar N30® intraoperative MRI since its introduction in 2013 in the Barcelona Clinic Hospital. MATERIAL AND METHODS: A prospective non-randomised study was conducted on cases operated on using iMRI and intention of complete removal up to October 2015...
October 14, 2016: Neurocirugía
https://www.readbyqxmd.com/read/27746042/rituximab-in-lymphoma-and-chronic-lymphocytic-leukaemia-a-practice-guideline
#8
A Prica, F Baldassarre, L K Hicks, K Imrie, T Kouroukis, M Cheung
Rituximab is the first monoclonal antibody to be approved for use by the US Food and Drug Administration in cancer. Its role in the treatment of non-Hodgkin lymphoma, including chronic lymphocytic leukaemia (CLL), has evolved significantly. We aimed to systematically review and update the literature on rituximab in lymphoma and CLL, and provide evidence-based consensus guidelines for its rational use. Validated methodology from the Cancer Care Ontario Program in Evidence-based Care was used. A comprehensive literature search was completed by a methodologist from the Hematology Disease Site Group of Cancer Care Ontario...
October 13, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27659833/neurosurgical-tools-to-extend-tumor-resection-in-pediatric-hemispheric-low-grade-gliomas-imri
#9
Mario Giordano, Cinta Arraez, Amir Samii, Madjid Samii, Concezio Di Rocco
INTRODUCTION: The treatment of low-grade gliomas (LGGs) in pediatric age is still controversial. However, most authors report longer life expectancy in case of completely removed cerebral gliomas. Intraoperative magnetic resonance imaging (iMRI) is increasingly utilized in the surgical management of intra-axial tumor in adults following the demonstration of its effectiveness. In this article, we analyze the management of LGG using iMRI focusing on its impact on resection rate and its limits in the pediatric population...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27651342/optimizing-the-extent-of-resection-and-minimizing-the-morbidity-in-insular-high-grade-glioma-surgery-by-high-field-intraoperative-mri-guidance
#10
Chen Li-Feng, Yang Yang, Ma Xiao-Dong, Yu Xin-Guang, Gui Qiu-Ping, Xu Bai-Nan, Zhou Ding-Biao
AIM: The author evaluated the impact of high-field intraoperative MRI (iMRI) and functional neuronavigation on insular high-grade glioma(HGG) surgery. MATERIAL AND METHODS: Between 2010 and 2014, 51 insular HGG patients underwent operations guided by combined high-field iMRI and functional neuronavigation.22 insular HGG patients underwent conventional neuronavigation operations were assessed as the control group. Tumor volumetric scan analysis, Karnofsky performance score (KPS) and follow-up results were reviewed retrospectively...
August 23, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27633706/real-time-intraoperative-mri-intracerebral-delivery-of-induced-pluripotent-stem-cell-derived-neurons
#11
Scott C Vermilyea, Jianfeng Lu, Miles Olsen, Scott Guthrie, Yunlong Tao, Eva M Fekete, Marissa K Riedel, Kevin Brunner, Carissa Boettcher, Viktorya Bondarenko, Ethan Brodsky, Walter F Block, Andrew Alexander, Su-Chun Zhang, Marina E Emborg
Induced pluripotent stem cell (iPSC)-derived neurons represent an opportunity for cell replacement strategies for neurodegenerative disorders such as Parkinson's disease (PD). Improvement in cell graft targeting, distribution and density can be key for disease modification. We have previously developed a trajectory guide system for Real-Time Intraoperative Magnetic Resonance Imaging (RT-IMRI) delivery of infusates, such as viral vector suspensions for gene therapy strategies. Intracerebral delivery of iPSCderived neurons presents different challenges than viral vectors, including limited cell survival if cells are kept at room temperature for prolonged periods of time, precipitation and aggregation of cells in the cannula and obstruction during injection, which must be solved for successful application of this delivery approach...
September 14, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27594580/the-clinical-utility-of-genetic-testing-of-tissues-from-pregnancy-losses
#12
C A Waterman, P Batstone, N Bown, L Cresswell, C Delmege, C J English, G Fews, L Grimsley, S Imrie, A Kulkarni, K Mann, R Johnson, S M Morgan, P Roberts, I Simonic, S Trueman, M Wall, D McMullan
OBJECTIVE: To map the current testing being undertaken following pregnancy loss across the UK and to examine the clinical utility in terms of identifying a cause for the loss and in identifying couples at risk of an unbalanced liveborn child. DESIGN: Retrospective audit. SETTING: UK, for the year 2014. POPULATION: An audit of 6465 referrals for genetic testing of tissue samples following pregnancy loss. METHODS: Data were obtained by questionnaire from 15 UK regional genetics laboratories...
September 5, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27583183/interventional-magnetic-resonance-imaging-guided-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-s-disease-patient-selection
#13
Hooman Azmi, Fiona Gupta, Mario Vukic, Jason Kreitner, Elizabeth Kera, Gregory Nicola, Sean Pierce, David Panush, Randy Cohen
BACKGROUND: Interventional magnetic resonance imaging (iMRI) guided deep brain stimulation (DBS) for Parkinson's disease (PD) has been shown to be effective. The costs of a dedicated intraoperative MRI may be prohibitive. The procedure can also be performed in a diagnostic scanner, however this presents challenges for utilization of time when the scanner is used both as a diagnostic and an interventional unit. This report outlines our novel methodology for patient selection for implantation in a diagnostic MR scanner, as an attempt to streamline the use of resources...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27553458/charge-density-waves-in-disordered-media-circumventing-the-imry-ma-argument
#14
Hitesh J Changlani, Norm M Tubman, Taylor L Hughes
Two powerful theoretical predictions, Anderson localization and the Imry-Ma argument, impose significant restrictions on the phases of matter that can exist in the presence of even the smallest amount of disorder in one-dimensional systems. These predictions forbid electrically conducting states and ordered states respectively. It was thus remarkable that a mechanism to circumvent Anderson localization relying on the presence of correlated disorder was found, that is also realized in certain biomolecular systems...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27482431/a-qualitative-assessment-of-barriers-and-facilitators-to-antiretroviral-adherence-in-thai-patients
#15
Melissa Phuphanich, Maneerat Rattanamahattana, Anchalee Avihingsanon, Ploenchan Chetchotisakd, Opass Putcharoen, Monica Gandhi, Annette H Sohn, John Imrie, Praphan Phanuphak, Stephen J Kerr
OBJECTIVES: Excellent adherence to combination antiretroviral therapy can suppress HIV replication and produce life expectancies nearing those of individuals without HIV infection. This qualitative study sought to identify the barriers and facilitators to good antiretroviral medication adherence in Thai patients living with HIV. METHODS: Semi-structured interviews were conducted with a convenience sample (n=21) of patients attending routine clinic visits at Srinagarind Hospital in Khon Kaen, or HIV-NAT, the Thai Red Cross AIDS Research Centre in Bangkok...
2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/27449637/a-suspicion-index-to-aid-screening-of-early-onset-niemann-pick-disease-type-c-np-c
#16
Mercedes Pineda, Eugen Mengel, Helena Jahnová, Bénédicte Héron, Jackie Imrie, Charles M Lourenço, Vanessa van der Linden, Parvaneh Karimzadeh, Vassili Valayannopoulos, Pavel Jesina, Juan V Torres, Stefan A Kolb
BACKGROUND: Niemann-Pick disease Type C (NP-C) is difficult to diagnose due to heterogeneous and nonspecific clinical presentation. The NP-C Suspicion Index (SI) was developed to identify patients with a high likelihood of NP-C; however, it was less reliable in patients aged <4 years. METHODS: An early-onset NP-C SI was constructed following retrospective chart review of symptom presentation in 200 patients from nine centres comprised of 106 NP-C cases, 31 non-cases and 63 controls...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27447288/understanding-the-twist-bend-nematic-phase-the-characterisation-of-1-4-cyanobiphenyl-4-yloxy-6-4-cyanobiphenyl-4-yl-hexane-cb6ocb-and-comparison-with-cb7cb
#17
Daniel A Paterson, Min Gao, Young-Ki Kim, Afsoon Jamali, Kirsten L Finley, Beatriz Robles-Hernández, Sergio Diez-Berart, Josep Salud, M Rosario de la Fuente, Bakir A Timimi, Herbert Zimmermann, Cristina Greco, Alberta Ferrarini, John M D Storey, David O López, Oleg D Lavrentovich, Geoffrey R Luckhurst, Corrie T Imrie
The synthesis and characterisation of the nonsymmetric liquid crystal dimer, 1-(4-cyanobiphenyl-4'-yloxy)-6-(4-cyanobiphenyl-4'-yl)hexane (CB6OCB) is reported. An enantiotropic nematic (N)-twist-bend nematic (NTB) phase transition is observed at 109 °C and a nematic-isotropic phase transition at 153 °C. The NTB phase assignment has been confirmed using polarised light microscopy, freeze fracture transmission electron microscopy (FFTEM), (2)H-NMR spectroscopy, and X-ray diffraction. The effective molecular length in both the NTB and N phases indicates a locally intercalated arrangement of the molecules, and the helicoidal pitch length in the NTB phase is estimated to be 8...
August 10, 2016: Soft Matter
https://www.readbyqxmd.com/read/27428785/evaluation-of-diffusion-tensor-imaging-based-tractography-of-the-corticospinal-tract-a-correlative-study-with-intraoperative-magnetic-resonance-imaging-and-direct-electrical-subcortical-stimulation
#18
Seyed Amirhossein Javadi, Arya Nabavi, Mario Giordano, Elham Faghihzadeh, Amir Samii
BACKGROUND: The accuracy of intraoperative diffusion tensor imaging (DTI)-based tractography of the corticospinal tract (CST) is crucial for its use in neurosurgical planning and its implementation in image-guided surgery. To the best of our knowledge, this is the largest prospective study of the intraoperative direct electrical subcortical stimulation (DESS) of the CST with intraoperative DTI tractography of the CST, with application of intraoperative magnetic resonance imaging (iMRI)...
July 13, 2016: Neurosurgery
https://www.readbyqxmd.com/read/27421048/community-perceptions-of-repeat-hiv-testing-experiences-of-the-anrs-12249-treatment-as-prevention-trial-in-rural-south-africa
#19
Joanna Orne-Gliemann, Thembelihle Zuma, Jeremiah Chikovore, Natasha Gillespie, Merridy Grant, Collins Iwuji, Joseph Larmarange, Nuala McGrath, France Lert, John Imrie
In the context of the ANRS 12249 Treatment as Prevention (TasP) trial, we investigated perceptions of regular and repeat HIV-testing in rural KwaZulu-Natal (South Africa), an area of very high HIV prevalence and incidence. We conducted two qualitative studies, before (2010) and during the early implementation stages of the trial (2013-2014), to appreciate the evolution in community perceptions of repeat HIV-testing over this period of rapid changes in HIV-testing and treatment approaches. Repeated focus group discussions were organized with young adults, older adults and mixed groups...
2016: AIDS Care
https://www.readbyqxmd.com/read/27404663/community-willingness-to-participate-in-a-dengue-study-in-aceh-province-indonesia
#20
Harapan Harapan, Samsul Anwar, Aslam Bustaman, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Rovy Pratama, Jonny Karunia Fajar, Abdul Malik Setiawan, Allison Imrie, Ulrich Kuch, David Alexander Groneberg, R Tedjo Sasmono, Meghnath Dhimal, Ruth Müller
BACKGROUND: Dengue virus infection is the most rapidly spreading vector-borne disease in the world. Essential research on dengue virus transmission and its prevention requires community participation. Therefore, it is crucial to understand the factors that are associated with the willingness of communities in high prevalence areas to participate in dengue research. The aim of this study was to explore factors associated with the willingness of healthy community members in Aceh province, Indonesia, to participate in dengue research that would require phlebotomy...
2016: PloS One
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