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https://www.readbyqxmd.com/read/28780845/-implementation-of-multimodal-navigation-combined-with-intraoperative-magnetic-resonance-imaging-in-the-frameless-stereotactic-biopsy-of-intracranial-lesions
#1
J S Zhang, X L Chen, Q Wang, Y Z Hou, G C Sun, F Y Li, X G Yu, B N Xu
Objective: To investigate the impact and value of multimodal navigation and intraoperative magnetic resonance imaging (iMRI) on the biopsy of intracranial lesions. Methods: From February, 2009 to December, 2016, this study enrolled 156 patients, who underwent multimodal navigation and iMRI-guided brain biopsy in the Neurosurgery Department of PLA General Hospital. Metabolic information was used for biopsy target selection. Intraoperative guidance helped biopsy trajectory avoid the eloquent structures. iMRI was performed to prove the biopsy accuracy and to revise the incorrect biopsy...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28770902/role-of-intra-operative-mri-imri-in-improving-extent-of-resection-and-survival-in-patients-with-glioblastoma-multiforme
#2
Inamullah Khan, Muhammad Waqas, Muhammad Shahzad Shamim
Multiple intraoperative aids have been introduced to improve the extent of resection (EOR) in Glioblastoma Multiforme (GBM) patients, avoiding any new neurological deficits. Intraoperative MRI (iMRI) has been debated for its utility and cost for nearly two decades in neurosurgical literature. Review of literature suggests improved EOR in GBM patients who underwent iMRI assisted surgical resections leading to higher overall survival (OS) and progression free survival (PFS). iMRI provides real time intraoperative imaging with reasonable quality...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28761393/a-combined-intravascular-mri-endoscope-and-intravascular-ultrasound-ivus-transducer-for-high-resolution-image-guided-ablation
#3
Xiaoyang Liu, Nicholas Ellens, Emery Williams, Everette Clif Burdette, Parag Karmarkar, Paul Bottomley
An intravascular MRI (IMRI) loopless antenna is combined for the first time with an intravascular water-cooled ultrasound ablation transducer as a possible tool for providing high-resolution MRI-guided ablations of pathological tissue via intravascular access. High resolution anatomical MRI, and real-time MRI thermometry were used to monitor ablation delivery in phantoms and tissue specimens. Results show that IMRI can guide IVUS-mediated directional ablation with minimal image artifacts. This permits the monitoring of thermal dose and therapy titration while minimizing potential thermal damage to the vessel wall...
April 2017: Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition
https://www.readbyqxmd.com/read/28737744/delivering-advanced-therapies-the-big-pharma-approach
#4
REVIEW
J Tarnowski, D Krishna, L Jespers, A Ketkar, R Haddock, J Imrie, S Kili
After two decades of focused development and some recent clinical successes, cell and gene therapy (CGT) is emerging as a promising approach to personalized medicines. Genetically engineered cells as a medical modality are poised to stand alongside or in combination with small molecule and biopharmaceutical approaches to bring new therapies to patients globally. Big pharma can play a vital role in industrializing CGT by focusing on diseases with high un-met medical need and compelling genetic evidence. Pharma should invest in manufacturing and supply chain solutions that deliver reproducible, high quality therapies at a commercially viable cost...
July 24, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28724723/nucleoredoxin-guards-against-oxidative-stress-by-protecting-antioxidant-enzymes
#5
Sophie Kneeshaw, Rumana Keyani, Valérie Delorme-Hinoux, Lisa Imrie, Gary J Loake, Thierry Le Bihan, Jean-Philippe Reichheld, Steven H Spoel
Cellular accumulation of reactive oxygen species (ROS) is associated with a wide range of developmental and stress responses. Although cells have evolved to use ROS as signaling molecules, their chemically reactive nature also poses a threat. Antioxidant systems are required to detoxify ROS and prevent cellular damage, but little is known about how these systems manage to function in hostile, ROS-rich environments. Here we show that during oxidative stress in plant cells, the pathogen-inducible oxidoreductase Nucleoredoxin 1 (NRX1) targets enzymes of major hydrogen peroxide (H2O2)-scavenging pathways, including catalases...
July 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28698020/first-outbreak-of-colonization-by-linezolid-and-glycopeptide-resistant-enterococcus-faecium-harbouring-the-cfr-gene-in-a-uk-nephrology-unit
#6
Teresa Inkster, John Coia, Danièle Meunier, Michel Doumith, Kate Martin, Rachel Pike, Laura Imrie, Hayley Kane, Marlene Hay, Camilla Wiuff, Julie Wilson, Chris Deighan, Katie L Hopkins, Neil Woodford, Robert Hill
AIM: To describe an outbreak of colonization by linezolid- and glycopeptide-resistant Enterococcus faecium harbouring the cfr gene, in a UK nephrology unit. METHODS: Isolates of linezolid-resistant E. faecium were typed by PFGE and examined by PCR and sequencing for the transmissible cfr gene that confers resistance to linezolid. Enhanced environmental cleaning, initial and weekly screening of all patients and monitoring of adherence to standard infection control precautions (SICPs) were implemented...
July 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28645466/the-scottish-enhanced-staphylococcus-aureus-bacteraemia-surveillance-programme-the-first-18-months-of-data-in-children
#7
F Murdoch, J Danial, A K Morris, E Czarniak, J L Bishop, E Glass, L J Imrie
BACKGROUND: National enhanced surveillance of Staphylococcus aureus bacteraemia (SAB) commenced on 1(st) October 2014 to gain a more in-depth understanding of the epidemiology of SAB in Scotland. Children under 16 years of age were analysed separately from adults because previous studies had demonstrated epidemiological differences. AIM: To identify risk factors and patient populations at greatest risk to enable the development of focused improvement plans. METHODS: All National Health Service (NHS) boards within NHS Scotland take part in the mandatory enhanced surveillance, with data collected by trained data collectors using nationally agreed definitions...
June 20, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28637756/high-resolution-meta-transcriptomics-reveals-the-ecological-dynamics-of-mosquito-associated-rna-viruses-in-western-australia
#8
Mang Shi, Peter Neville, Jay Nicholson, John-Sebastian Eden, Allison Imrie, Edward C Holmes
Mosquitoes harbour a high diversity of RNA viruses, including many that impact human health. Despite a growing effort to describe the extent and nature of the mosquito virome, little is known about how these viruses persist, spread, and interact with both their hosts and other microbes. To address this issue we performed a meta-transcriptomics analysis of 12 Western Australian mosquito populations structured by species and geographic location. Our results identified the complete genomes of 24 species of RNA viruses from a diverse range of viral families and orders, among which 19 are newly described...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28624561/safety-utility-and-clinical-results-of-continuous-intraoperative-electrophysiological-monitoring-in-1-5t-imri-guided-surgery
#9
Martin Breitkopf, Sotirios Bisdas, Marina Liebsch, Felix Behling, Benjamin Bender, Marcos Tatagiba, Constantin Roder
OBJECTIVE: To show that the combined use of intraoperative high-field MRI (iMRI) and electrophysiological monitoring (IOM) is feasible, safe and beneficial for patients. METHODS: The setup, surgical, imaging and clinical results of 110 patients with eloquent intracranial lesions with the combined use of 1.5T iMRI and IOM were analyzed. RESULTS: 187 iMRI scans were performed with IOM needles in place, resulting in a total experience of using more than 4000 electrodes in the iMRI...
June 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28615151/parkinson-s-disease-patient-preference-and-experience-with-various-methods-of-dbs-lead-placement
#10
Sara C LaHue, Jill L Ostrem, Nicholas B Galifianakis, Marta San Luciano, Nathan Ziman, Sarah Wang, Caroline A Racine, Philip A Starr, Paul S Larson, Maya Katz
INTRODUCTION: Physiology-guided deep brain stimulation (DBS) surgery requires patients to be awake during a portion of the procedure, which may be poorly tolerated. Interventional MRI-guided (iMRI) DBS surgery was developed to use real-time image guidance, obviating the need for patients to be awake during lead placement. METHODS: All English-speaking adults with PD who underwent iMRI DBS between 2010 and 2014 at our Center were invited to participate. Subjects completed a structured interview that explored perioperative preferences and experiences...
April 17, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28614824/compact-intraoperative-mri-stereotactic-accuracy-and-future-directions
#11
Daniel Markowitz, Dishen Lin, Sussan Salas, Nina Kohn, Michael Schulder
BACKGROUND: Intraoperative imaging must supply data that can be used for accurate stereotactic navigation. This information should be at least as accurate as that acquired from diagnostic imagers. OBJECTIVES: The aim of this study was to compare the stereotactic accuracy of an updated compact intraoperative MRI (iMRI) device based on a 0.15-T magnet to standard surgical navigation on a 1.5-T diagnostic scan MRI and to navigation with an earlier model of the same system...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28602702/the-scottish-enhanced-staphylococcus-aureus-bacteraemia-surveillance-programme-the-first-18-months-of-data-in-adults
#12
F Murdoch, J Danial, A K Morris, E Czarniak, J L Bishop, E Glass, L J Imrie
BACKGROUND: Staphylococcus aureus bacteraemia (SAB) is the second most common source of positive blood cultures, after Escherichia coli, reported within NHS Scotland. Laboratory surveillance has been mandatory in Scotland for SAB since 2001. AIM: To gain an understanding of the epidemiology of SAB cases and associated risk factors for healthcare and true community onset. Identification of these factors and the patient populations at greatest risk enables the development of focused improvement plans...
June 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28506599/application-of-vadose-zone-monitoring-system-for-real-time-characterization-of-leachate-percolation-in-and-under-a-municipal-landfill
#13
Imri Aharoni, Hagar Siebner, Ofer Dahan
Leachates from solid-waste landfills are considered a severe threat to groundwater quality. The fate of pollutants in the waste and underlying unsaturated zone is crucial for evaluating environmental risks and selecting a restoration strategy. In this study, a vadose-zone monitoring system (VMS) installed in a municipal landfill was used, for the first time, to continuously track leachates percolation dynamics and assess their chemical transformation across the entire thickness of the waste body (15m) and underlying unsaturated zone (16m) to the water table...
May 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28489618/core-competencies-or-a-competent-core-a-scoping-review-and-realist-synthesis-of-invasive-bedside-procedural-skills-training-in-internal-medicine
#14
Ryan Brydges, Lynfa Stroud, Brian M Wong, Eric S Holmboe, Kevin Imrie, Rose Hatala
PURPOSE: Invasive bedside procedures are core competencies for internal medicine, yet no formal training guidelines exist. The authors conducted a scoping review and realist synthesis to characterize current training for lumbar puncture, arthrocentesis, paracentesis, thoracentesis, and central venous catheterization. They aimed to collate how educators justify using specific interventions, establish which interventions have the best evidence, and offer directions for future research and training...
May 9, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28452549/reduction-of-electron-repulsion-and-enhancement-of-t_-c-in-small-diffusive-superconducting-grains
#15
Sabyasachi Tarat, Yuval Oreg, Yoseph Imry
The superconducting properties of small metallic grains has been a topic of active research for half a century now. Early experiments demonstrated a remarkable rise in the critical temperature, T_{c}, with reducing grain size in a variety of materials. In two-dimensional diffusive superconductors, T_{c} is decreased due to enhanced Coulomb repulsion. We propose that in finite-size grains the diffusive enhancement of the Coulomb repulsion is weakened and leads ultimately to an increase in T_{c} in isolated, disordered two-dimensional grains...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28437465/serological-evidence-for-transmission-of-multiple-dengue-virus-serotypes-in-papua-new-guinea-and-west-papua-prior-to-1963
#16
Dagwin Luang-Suarkia, Timo Ernst, Michael P Alpers, Ralph Garruto, David Smith, Allison Imrie
Little is known about the natural history of dengue in Papua New Guinea (PNG). We assessed dengue virus (DENV)-specific neutralizing antibody profiles in serum samples collected from northern and southern coastal areas and the highland region of New Guinea between 1959 and 1963. Neutralizing antibodies were demonstrated in sera from the northern coast of New Guinea: from Sabron in Dutch New Guinea (now known as West Papua) and from four villages in East Sepik in what is now PNG. Previous monotypic infection with DENV-1, DENV-2, and DENV-4 was identified, with a predominance of anti-DENV-2 neutralizing antibody...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28434959/analysis-of-137-patients-who-underwent-endoscopic-transsphenoidal-pituitary-adenoma-resection-under-high-field-intraoperative-magnetic-resonance-imaging-navigation
#17
Huaping Zhang, Fuyu Wang, Tao Zhou, Peng Wang, Xiaolei Chen, Jiashu Zhang, Dingbiao Zhou
BACKGROUND: Pure endoscopic resection has become the most popular surgical approach for pituitary adenoma. Intraoperative magnetic resonance imaging (iMRI) systems have been in use for endoscopic resection of pituitary adenomas. This study aimed to evaluate the effectiveness of iMRI and neuroimaging navigation techniques during endoscopic endonasal transsphenoidal surgery of pituitary adenomas. METHODS: Data from 137 patients who underwent resection of endoscopic pituitary adenoma under 1...
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28367747/hiv-risk-and-prevention-among-men-who-have-sex-with-men-in-rural-south-africa
#18
Kabelo Maleke, Nosipho Makhakhe, Remco Ph Peters, Geoffrey Jobson, Glenn De Swardt, Joseph Daniels, Timothy Lane, James A McIntyre, John Imrie, Helen Struthers
Rural South African men who have sex with men (MSM) are likely to be underserved in terms of access to relevant healthcare and HIV prevention services. While research in urban and peri-urban MSM populations has identified a range of factors affecting HIV risk in South African MSM, very little research is available that examines HIV risk and prevention in rural MSM populations. This exploratory study begins to address this lack by assessing perceptions of HIV risk among MSM in rural Limpopo province. Using thematic analysis of interview and discussion data, two overarching global themes that encapsulated participants' understandings of HIV risk and the HIV risk environment in their communities were developed...
March 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28331888/new-concept-on-an-integrated-interior-magnetic-resonance-imaging-and-medical-linear-accelerator-system-for-radiation-therapy
#19
Xun Jia, Zhen Tian, Yan Xi, Steve B Jiang, Ge Wang
Image guidance plays a critical role in radiotherapy. Currently, cone-beam computed tomography (CBCT) is routinely used in clinics for this purpose. While this modality can provide an attenuation image for therapeutic planning, low soft-tissue contrast affects the delineation of anatomical and pathological features. Efforts have recently been devoted to several MRI linear accelerator (LINAC) projects that lead to the successful combination of a full diagnostic MRI scanner with a radiotherapy machine. We present a new concept for the development of the MRI-LINAC system...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28297573/magnetic-resonance-imaging-guided-delivery-of-neural-stem-cells-into-the-basal-ganglia-of-nonhuman-primates-reveals-a-pulsatile-mode-of-cell-dispersion
#20
Kristen E Malloy, Jinqi Li, Gourav R Choudhury, April Torres, Shruti Gupta, Chris Kantorak, Tim Goble, Peter T Fox, Geoffrey D Clarke, Marcel M Daadi
Optimal stem cell delivery procedures are critical to the success of the cell therapy approach. Variables such as flow rate, suspension solution, needle diameter, cell density, and tissue mechanics affect tissue penetration, backflow along the needle, and the dispersion and survival of injected cells during delivery. Most cell transplantation centers engaged in human clinical trials use custom-designed cannula needles, syringes, or catheters, sometimes precluding the use of magnetic resonance imaging (MRI)-guided delivery to target tissue...
March 2017: Stem Cells Translational Medicine
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