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retinopathy of prematurity

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https://www.readbyqxmd.com/read/29453434/post-ligation-cardiac-syndrome-is-associated-with-increased-morbidity-in-preterm-infants
#1
Timothy J B Ulrich, Taylor P Hansen, Kimberly J Reid, Michael A Bingler, Steven L Olsen
OBJECTIVE: The influence of post-ligation cardiac syndrome (PLCS), a complication of patent ductus arteriosus (PDA) ligations, on neonatal outcomes is unknown. The purpose of this study was to determine the risks of PLCS on severe pulmonary morbidity and severe retinopathy of prematurity (ROP). STUDY DESIGN: Retrospective cohort study of infants who underwent a PDA ligation between 2006 and 2015. Data were collected on patients with and without PLCS. The primary outcome was the difference in severe bronchopulmonary dysplasia (BPD) between groups...
February 16, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29453109/genetic-basis-of-diabetic-kidney-disease-and-other-diabetic-complications
#2
REVIEW
Niina Sandholm, Per-Henrik Groop
Diabetic kidney disease and other long-term complications are common in diabetes, and comprise the main cause of co-morbidity and premature mortality in individuals with diabetes. While familial clustering and heritability have been reported for all diabetic complications, the genetic background and the molecular mechanisms remain poorly understood. In recent years, genome-wide association studies have identified a few susceptibility loci for the renal complications as well as for diabetic retinopathy, diabetic cardiovascular disease and mortality...
February 13, 2018: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29444655/a-systematic-study-on-the-prevention-and-treatment-of-retinopathy-of-prematurity-in-china
#3
Shuman Xu, Zhijiang Liang, Qiyun Du, Zhankui Li, Guangming Tan, Chuan Nie, Yang Yang, Xuzai Lv, Chunyi Zhang, Xianqiong Luo
BACKGROUND: To identify the prevention situation, the main factors influencing prevention effects and to develop control measures over retinopathy of prematurity in China. METHODS: Using stratified random sampling method, we randomly selected 23 provincial and ministerial hospitals (8 in Guangdong province, 5 in Hunan province and 10 in Shaanxi province), 81 municipal hospitals (38 in Guangdong province, 19 in Hunan province and 24 in Shaanxi province), 180 district and county hospitals (76 in Guangdong province, 57 in Hunan province and 47 in Shaanxi province) in China...
February 14, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29443362/outcomes-of-intravitreal-bevacizumab-and-diode-laser-photocoagulation-for-treatment-warranted-retinopathy-of-prematurity
#4
Tiffany A Chen, Ira H Schachar, Darius M Moshfeghi
BACKGROUND AND OBJECTIVE: To investigate the outcomes of infants with treatment-warranted retinopathy of prematurity (TW-ROP) who received intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA) (IVB) injections as compared to diode laser photocoagulation (DLP). PATIENTS AND METHODS: Data from the Stanford University Network for Diagnosis of Retinopathy of Prematurity database and inpatients at Stanford Children's Hospital were retrospectively reviewed for premature newborns with TW-ROP treated with DLP or 0...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29433145/effect-of-cord-blood-magnesium-level-at-birth-on-non-neurologic-neonatal-outcomes
#5
James M Edwards, Laura E Edwards, Geeta K Swamy, Chad A Grotegut
OBJECTIVE: We examined the effects of magnesium sulfate on non-neurologic neonatal outcomes with respect to cord blood magnesium level. STUDY DESIGN: We conducted a secondary analysis of the Maternal-Fetal Medicine Units Beneficial Effects of Antenatal Magnesium (MFMU BEAM) trial comparing the upper and lower quintiles of cord blood magnesium level. Outcomes included cerebral palsy (CP), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and assessments of mental and motor disability...
February 12, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29431872/interventions-to-prevent-hypothermia-at-birth-in-preterm-and-or-low-birth-weight-infants
#6
REVIEW
Emma M McCall, Fiona Alderdice, Henry L Halliday, Sunita Vohra, Linda Johnston
BACKGROUND: Newborn admission temperature is a strong predictor of outcomes across all gestations. Hypothermia immediately after birth remains a worldwide issue and, if prolonged, is associated with harm. Keeping preterm infants warm is difficult even when recommended routine thermal care guidelines are followed in the delivery room. OBJECTIVES: To assess the efficacy and safety of interventions designed for prevention of hypothermia in preterm and/or low birth weight infants applied within 10 minutes after birth in the delivery room, compared with routine thermal care or any other single/combination of intervention(s) also designed for prevention of hypothermia in preterm and/or low birth weight infants applied within 10 minutes after birth in the delivery room...
February 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29423517/the-prematurity-of-recommending-particular-polyunsaturated-fatty-acid-supplements-for-retinopathy-of-prematurity
#7
M Elizabeth Hartnett
No abstract text is available yet for this article.
February 8, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29423508/association-of-retinopathy-of-prematurity-with-low-levels-of-arachidonic-acid-a-secondary-analysis-of-a-randomized-clinical-trial
#8
Chatarina A Löfqvist, Svetlana Najm, Gunnel Hellgren, Eva Engström, Karin Sävman, Anders K Nilsson, Mats X Andersson, Anna-Lena Hård, Lois E H Smith, Ann Hellström
Importance: Mice with oxygen-induced retinopathy fed matched diets except for ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs) vs ω-6 LC-PUFAs demonstrate relative antiangiogenic and neuroprotective associations of ω-3 LC-PUFAs. However, supplementing preterm infants with LC-PUFAs has been inconsistent in reducing major preterm morbidities. However, few studies measured serum lipid levels after supplementation. Objective: To examine the associated risk of retinopathy of prematurity (ROP) from the levels of circulating ω-3 and ω-6 LC-PUFAs...
February 8, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29421328/the-effect-of-a-single-anti-vascular-endothelial-growth-factor-injection-on-neonatal-growth-and-organ-development-in-vivo-study
#9
Sina Khalili, Yulia Shifrin, Jingyi Pan, Jaques Belik, Kamiar Mireskandari
Retinopathy of prematurity (ROP) is one of the leading causes of blindness in preterm Infants. Anti-vascular endothelial growth factor (VEGF) is emerging as a promising treatment, but there is insufficient evidence on their safety. We investigate the effect of systemic anti-VEGF in rat pups with equivalent maturity to a 32 week neonate. A single dose of either anti-VEGF antibody (n = 7) or saline (control group; n = 6) was administered to newborn rats intra-peritoneally on the first day of life. 14 days' post treatment, the serum concentration of anti-VEGF was measured and the brain, lung, heart, kidney and liver were harvested and weighed...
January 31, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29414835/choroidal-thickness-with-swept-source-optical-coherence-tomography-versus-foveal-morphology-in-young-children-with-a-history-of-prematurity
#10
Wadim Bowl, Marianne Bowl, Silke Schweinfurth, Kerstin Holve, Monika Andrassi-Darida, Knut Stieger, Birgit Lorenz
AIM: Comparison of choroidal thickness (CT) and foveal morphology as seen with swept-source optical coherence tomography (SS-OCT) in children with a history of treated or spontaneously regressed retinopathy of prematurity (tROP or srROP) to assess the impact on best-corrected visual acuity (BCVA). METHODS: CT was measured by SS-OCT (DRI-OCT Triton; Topcon, USA) single scans of a 6-mm diameter around the fovea in 17 children with tROP or srROP (4-7 years of age) and compared to 25 controls (age-matched children and adults)...
February 7, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29411894/melatonin-attenuated-retinal-neovascularization-and-neuroglial-dysfunction-by-inhibition-of-hif-1%C3%AE-vegf-pathway-in-oxygen-induced-retinopathy-mice
#11
REVIEW
Yue Xu, Xi Lu, Yaguang Hu, Boyu Yang, Ching-Kit Tsui, Shanshan Yu, Lin Lu, Xiaoling Liang
Retinopathy of prematurity (ROP) is a retinopathy characterized by retinal neovascularization (RNV) occurring in preterm infants treated with high concentrations of oxygen and may lead to blindness in severe cases. Currently, anti-VEGF therapy is a major treatment for ROP, but it is costly and may cause serious complications. The previous study has demonstrated that melatonin exerted neuroprotective effect against retinal ganglion cell death induced by hypoxia in neonatal rats. However, whether melatonin is anti-angiogenic and neuroglial protective in the progression of ROP remains unknown...
February 7, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29405832/beyond-sepsis-staphylococcus-epidermidis-is-an-underestimated-but-significant-contributor-to-neonatal-morbidity
#12
Ying Dong, Christian P Speer, Kirsten Glaser
Staphylococcus epidermidis accounts for the majority of cases of neonatal sepsis. Moreover, it has been demonstrated to be associated with neonatal morbidities, such as bronchopulmonary dysplasia (BPD), white matter injury (WMI), necrotizing enterocolitis (NEC) and retinopathy of prematurity (ROP), which affect short-term and long-term neonatal outcome. Imbalanced inflammation has been considered to be a major underlying mechanism of each entity. Conventionally regarded as a harmless commensal on human skin, S...
February 6, 2018: Virulence
https://www.readbyqxmd.com/read/29405045/telemedicine-for-rop
#13
Parag K Shah, Appanraj Ramya, Venkatapathy Narendran
With the increasing survival of preterm babies in the Asia-Pacific region, there has been an increase in the incidence of retinopathy of prematurity (ROP). There is also a lack of trained ophthalmologists to screen for this disease. New strategies for screening of ROP are required, wherein the load on the ophthalmologist can be reduced. Telemedicine is an excellent tool to address this need. This paper reviews the initial studies comparing digital imaging with indirect ophthalmoscopy, the current active ROP telescreening programs in the world, and ends with studies dealing with automated diagnosis of ROP...
February 1, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29403586/efficacy-of-intravitreal-bevacizumab-for-the-treatment-of-zone-i-type-1-retinopathy-of-prematurity
#14
Reza Karkhaneh, Hamidreza Torabi, Alireza Khodabande, Ramak Roohipoor, Mohammad Riazi-Esfahani
Purpose: To describe the efficacy of intravitreal bevacizumab for the treatment of type 1 retinopathy of prematurity (ROP) in zone I. Methods: Preterm infants with type 1 ROP in zone I (zone I ROP, any stage with plus disease or zone I ROP, stage 3 without plus disease) were enrolled in this prospective study. Intravitreal bevacizumab (0.625 mg/0.025 ml) was injected under topical anesthesia. Patients were followed weekly for 4 weeks and then biweekly till 90 weeks gestational age...
January 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29392321/retinopathy-of-prematurity-among-very-low-birth-weight-infants-in-china-incidence-and-perinatal-risk-factors
#15
Tian Wu, Li Zhang, Yu Tong, Yi Qu, Bin Xia, Dezhi Mu
Purpose: Retinopathy of prematurity (ROP) is the leading cause of blindness in children worldwide. This study aimed to determine the incidence and perinatal risk factors for ROP in very low-birth-weight (VLBW) Chinese infants. Methods: A retrospective study of the medical records of 504 VLBW infants screened for ROP from 2012 to 2015 was performed in West China Second University Hospital. VLBW infants were examined according to the Royal College of Ophthalmologists ROP guideline and retinopathy was graded following the International Classification of ROP...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29386650/targeted-knockdown-of-overexpressed-vegfa-or-vegf164-in-m%C3%A3-ller-cells-maintains-retinal-function-by-triggering-different-signaling-mechanisms
#16
Silke Becker, Haibo Wang, Aaron B Simmons, Thipparat Suwanmanee, Gregory J Stoddard, Tal Kafri, M Elizabeth Hartnett
Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-hairpin RNAs to VEGFA or VEGF164 via subretinal lentivirus delivery (L-VEGFAshRNA, L-VEGF164shRNA) on retinal structure and function in a rat OIR model. Lectin-stained retinal flat mounts analyzed for areas of avascular/total retina (AVA) and intravitreal neovascular/total retina (IVNV) showed initial significantly reduced IVNV by L-VEGFAshRNA and L-VEGF164shRNA compared to control, luciferase-shRNA lentivirus, without late recurrence...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378530/comparison-of-efficacy-between-anti-vascular-endothelial-growth-factor-vegf-and-laser-treatment-in-type-1-and-threshold-retinopathy-of-prematurity-rop
#17
Zijing Li, Yichi Zhang, Yunru Liao, Rui Zeng, Peng Zeng, Yuqing Lan
BACKGROUND: Retinopathy of Prematurity (ROP) is one of the most common causes of childhood blindness worldwide. Comparisons of anti-VEGF and laser treatments in ROP are relatively lacking, and the data are scattered and limited. The objective of this meta-analysis is to compare the efficacy of both treatments in type-1 and threshold ROP. METHODS: A comprehensive literature search on ROP treatment was conducted using PubMed and Embase up to March 2017 in all languages...
January 30, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29376233/management-of-retinopathy-of-prematurity-use-of-anti-vegf-therapy
#18
Kimberly D Tran, Linda A Cernichiaro-Espinosa, Audina M Berrocal
Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Although laser photocoagulation re-mains the gold standard for treating threshold and prethreshold disease (type 1 ROP), the off-label use of anti‒vascular endothelial growth factor (anti-VEGF) therapy to treat ROP is increasing. Benefits include acute regression of ROP, growth of retinal vasculature beyond the demarcation line, lesser degree of myopia and peripheral visual field loss, and avoidance of sedation and intubation required for laser...
January 26, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29376007/effect-of-two-different-doses-of-intravitreal-bevacizumab-with-temporal-retina-sparing-laser-photocoagulation-for-retinopathy-of-prematurity
#19
A Young Choi, Hochan Cho, Yu Cheol Kim
This study aims to compare the efficacy and safety between two different doses of intravitreal bevacizumab (IVB) injection with temporal retina-sparing laser (TRSL) photocoagulation for retinopathy of prematurity (ROP). We retrospectively evaluated 22 eyes of ROP infants who underwent IVB combined with partial TRSL for stage 3+ zone I or posterior zone II ROP. Laser photocoagulation was applied on the avascular retina, sparing two-disc-diameter width temporal avascular area anterior to ridge. A half dose (0...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29372144/antenatal-corticosteroids-and-outcomes-of-preterm-small-for-gestational-age-neonates-in-a-single-medical-center
#20
Woo Jeng Kim, Young Sin Han, Hyun Sun Ko, In Yang Park, Jong Chul Shin, Jeong Ha Wie
Objective: This study investigated the effect of an antenatal corticosteroid (ACS) in preterm small-for-gestational-age (SGA) neonate. Methods: This study was a retrospective cohort study. We compared women who received ACS with unexposed controls and evaluated neonatal complications among those having a singleton SGA neonate born between 29 and 34 complete gestational weeks. The neonates born after 32 weeks of gestation were divided into subgroups. Multivariable logistic regression analysis was performed...
January 2018: Obstetrics & Gynecology Science
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