Geidy E Serrano, Jessica Walker, Courtney Nelson, Michael Glass, Richard Arce, Anthony Intorcia, Madison P Cline, Natalie Nabaty, Amanda Acuña, Ashton Huppert Steed, Lucia I Sue, Christine Belden, Parichita Choudhury, Eric Reiman, Alireza Atri, Thomas G Beach
Synaptic transmission is essential for nervous system function and the loss of synapses is a known major contributor to dementia. Alzheimer's disease dementia (ADD) is characterized by synaptic loss in the mesial temporal lobe and cerebral neocortex, both of which are brain areas associated with memory and cognition. The association of synaptic loss and ADD was established in the late 1980s, and it has been estimated that 30-50% of neocortical synaptic protein is lost in ADD, but there has not yet been a quantitative profiling of different synaptic proteins in different brain regions in ADD from the same individuals...
March 8, 2024: International Journal of Molecular Sciences