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Endocrine guidelines

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https://www.readbyqxmd.com/read/29933238/endocrine-disruptors-in-the-diet-of-male-sparus-aurata-modulation-of-the-endocannabinoid-system-at-the-hepatic-and-central-level-by-di-isononyl-phthalate-and-bisphenol-a
#1
Isabel Forner-Piquer, Constantinos C Mylonas, Josep Calduch-Giner, Francesca Maradonna, Giorgia Gioacchini, Marco Allarà, Fabiana Piscitelli, Vincenzo Di Marzo, Jaume Pérez-Sánchez, Oliana Carnevali
The increasing manufacture of plastics and their mismanagement has turned plastic into a ubiquitous waste in the marine environment. Among all the substances conforming the plastic items, the effects of a dietary Bisphenol A (BPA) and Di-isononyl phthalate (DiNP) have been evaluated in adult male gilthead sea bream, focusing on their effects in the modulation of the Endocannabinoid System (ECS). In zebrafish, the ECS has been recently chosen as a new target for the activity of some Endocrine Disrupting Chemicals (EDC), since it represents a complex lipid signaling network essential for the well-being of the organisms...
June 19, 2018: Environment International
https://www.readbyqxmd.com/read/29909163/update-on-multiple-endocrine-neoplasia-type-1-and-2
#2
Abdallah Al-Salameh, Camille Baudry, Régis Cohen
Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid habitus, mucosal neuromas)...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29905821/corrigendum-for-endocrine-treatment-of-gender-dysphoric-gender-incongruent-persons-an-endocrine-society-clinical-practice-guideline
#3
(no author information available yet)
No abstract text is available yet for this article.
June 13, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29897580/recent-topics-around-multiple-endocrine-neoplasia-type-1
#4
Stephen J Marx
Introduction: Multiple endocrine neoplasia type 1 (MEN1) is complex with regard to clinical expressions, management, and molecular pathways. Advances are being made broadly and in focused aspects. Selected topics are presented for their developments since publication of the most recent MEN1 consensus guidelines 6 years ago. Methods: Topics were selected for clinical impact or broad interest or both. For each topic, information was obtained from original reports and reviews...
April 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29895022/diagnosis-and-treatment-of-metabolic-acidosis-in-patients-with-chronic-kidney-disease-position-statement-of-the-working-group-of-the-polish-society-of-nephrology
#5
Marcin Adamczak, Anna Masajtis-Zagajewska, Oktawia Mazanowska, Katarzyna Madziarska, Tomasz Stompór, Andrzej Więcek
Metabolic acidosis is commonly found in patients with chronic kidney disease (CKD), and its causes are: impaired ammonia excretion, reduced tubular bicarbonate reabsorption and insufficient renal bicarbonate production in relation to the amount of acids synthesised by the body and ingested with food. As the consequence, numerous metabolic abnormalities develop, which may lead to dysfunction of several organs. In observational studies, it has been found that CKD patients with metabolic acidosis are characterised by faster progression of kidney disease towards end stage kidney failure, and by increased mortality...
June 7, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29891521/receipt-of-guideline-concordant-care-among-older-women-with-stage-i-iii-breast-cancer-a-population-based-study
#6
Traci LeMasters, S Suresh Madhavan, Usha Sambamoorthi, Hannah W Hazard-Jenkins, Kimberly M Kelly, Dustin Long
Background: This study examined receipt of guideline-concordant care (GCC) according to evidence-based treatment guidelines and quality measures and specific types of treatment among older women with breast cancer. Patients and Methods: A total of 142,433 patients aged ≥66 years diagnosed with stage I-III breast cancer between 2007 and 2011 were identified in the SEER-Medicare linked database. Algorithms considering cancer characteristics and the appropriate course of care as per guidelines versus actual care received determined receipt of GCC...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29891226/evaluation-and-treatment-of-gender-dysphoria-to-prepare-for-gender-confirmation-surgery
#7
REVIEW
Miriam Hadj-Moussa, Dana A Ohl, William M Kuzon
BACKGROUND: Gender dysphoria is the experience of marked distress due to incongruence between genetically determined gender and experienced gender. Treatment of gender dysphoria should be individualized and multidisciplinary, involving a combination of psychotherapy, social gender transition, cross-sex hormone therapy, gender-affirming surgery, and/or ancillary procedures and services. The goal of all treatment modalities is to alleviate distress and affirm the patient's experienced gender identity...
June 8, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29886394/adjuvant-endocrine-therapy-in-premenopausal-patients-with-hormone-receptor-positive-early-breast-cancer-evidence-evaluation-and-grade-recommendations-by-the-italian-association-of-medical-oncology-aiom
#8
REVIEW
Stefania Gori, Fabio Puglisi, Michela Cinquini, Giovanni Pappagallo, Antonio Frassoldati, Laura Biganzoli, Laura Cortesi, Alba Fiorentino, Catia Angiolini, Corrado Tinterri, Andrea De Censi, Alessia Levaggi, Lucia Del Mastro
Premenopausal women with hormone receptor-positive early breast cancer are candidates for adjuvant endocrine therapy, as recommended by the major international guidelines. To date, adjuvant endocrine options for premenopausal women include tamoxifen with or without ovarian function suppression (OFS) or an aromatase inhibitor with OFS. Multiple strategies for endocrine treatment of premenopausal women with hormone-responsive breast cancer have been assessed, and the results of randomised clinical trials have been reported over the last years...
June 7, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29875471/variation-in-treatment-and-survival-of-older-patients-with-non-metastatic-breast-cancer-in-five-european-countries-a-population-based-cohort-study-from-the-eurecca-breast-cancer-group
#9
Marloes G M Derks, Esther Bastiaannet, Mandy Kiderlen, Denise E Hilling, Petra G Boelens, Paul M Walsh, Elizabeth van Eycken, Sabine Siesling, John Broggio, Lynda Wyld, Maciej Trojanowski, Agnieszka Kolacinska, Justyna Chalubinska-Fendler, Ana Filipa Gonçalves, Tomasz Nowikiewicz, Wojciech Zegarski, Riccardo A Audisio, Gerrit-Jan Liefers, Johanneke E A Portielje, Cornelis J H van de Velde
BACKGROUND: Older patients are poorly represented in breast cancer research and guidelines do not provide evidence based recommendations for this specific group. We compared treatment strategies and survival outcomes between European countries and assessed whether variance in treatment patterns may be associated with variation in survival. METHODS: Population-based study including patients aged ≥ 70 with non-metastatic BC from cancer registries from the Netherlands, Belgium, Ireland, England and Greater Poland...
June 7, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29875419/secondary-findings-from-next-generation-sequencing-what-does-actionable-in-childhood-really-mean
#10
Julie Richer, Anne-Marie Laberge
PURPOSE: We aimed to assess the definition of actionability of secondary findings in childhood, using a screening framework. METHODS: For 31 disorders on the American College of Medical Genetics and Genomics SF v.2.0 list, World Health Organization screening criteria were applied to assess actionability in childhood. RESULTS: The age of onset was variable. We categorized disorders based on the proportion of cases that presented in childhood: rare (n = 6), fewer than half the cases (n = 9), the majority of cases (n = 12), or unclear (n = 4)...
June 6, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29873108/quantitative-determination-of-pancreas-size-using-anatomical-landmarks-and-its-clinical-relevance-a-systematic-literature-review
#11
S DeSouza, H Yoon, R Singh, M Petrov
INTRODUCTION: There have been many reports of altered pancreas size in diseases of the endocrine and exocrine pancreas, but few attempts to quantify such changes. The aim of this study was to conduct a systematic literature review, documenting the methodology and quantitative data in studies reporting on pancreas size. MATERIALS AND METHODS: Three electronic databases (EMBASE, Scopus, and MEDLINE) were searched by two reviewers independently. Studies of humans were included if they compared pancreas size (reported as pancreas diameters, areas, and/or lengths) between diseased populations and controls...
June 5, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29843401/consensus-in-gestational-diabetes-mellitus-looking-for-the-holy-grail
#12
REVIEW
Mukesh M Agarwal
The world's pre-eminent diabetes, obstetric, endocrine, and health organizations advocate a plethora of diverse algorithms for the screening, diagnosis, management, and follow-up of gestational diabetes mellitus (GDM). Additionally, there are regional recommendations of local health societies. Several of these proposals for GDM are contentious because some of them were developed from unscientific studies, based on expert-opinion, catered to preserve resources, and subjectively modified for convenience. Due to the wide variety of choices available, the approach to GDM can be extremely diverse even within the same hospital...
May 28, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29807560/the-screening-diagnosis-treatment-and-follow-up-of-breast-cancer
#13
Achim Wöckel, Ute-Susann Albert, Wolfgang Janni, Anton Scharl, Rolf Kreienberg, Tanja Stüber
BACKGROUND: Breast cancer is the most common cancer in women. The German S3 guideline of 2012 has now been updated to take account of advances in the early detection, diagnostic evaluation, treatment, and follow-up care of this disease. METHODS: The updating process was based on the adaptation of identified source guidelines and on reviews of the scientific evidence. A systematic search in multiple literature databases was carried out, and the full texts of the selected articles were evaluated...
May 4, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29805397/lack-of-uniformity-in-screening-diagnosis-and-management-of-gestational-diabetes-mellitus-among-health-practitioners-across-major-cities-of-pakistan
#14
Syed Hunain Riaz, Muhammad Shais Khan, Ali Jawa, Madeeha Hassan, Javed Akram
Objective: To determine knowledge, attitude and practice (KAP) regarding management of Gestational Diabetes Mellitus (GDM) among Health Care Providers in major cities of Pakistan. Methods: A knowledge, attitude and practice (KAP) questionnaire based study was conducted in major cities in Pakistan from health care providers in public and private hospitals and clinics. Questionnaires were provided to the health care providers regarding screening, diagnosis and management of patients with GDM...
March 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29801584/tamoxifen-and-cyp2d6-a-controversy-in-pharmacogenetics
#15
Deirdre P Cronin-Fenton, Per Damkier
Tamoxifen reduces the rate of breast cancer recurrence by about one-half. It is converted to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6) and transported by ATP-binding cassette transporters. Genetic polymorphisms that confer reduced CYP2D6 activity or concurrent use of CYP2D6-inhibiting drugs may reduce the clinical efficacy of tamoxifen. The issue of the clinical utility of CYP2D6 genotype testing is subject to considerable and ongoing academic and clinical controversy...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29800912/comparative-study-of-substituted-poly-4-vinylbenzyl-chloride-ethylene-glycol-dimethacrylate-sorbents-for-enrichment-of-selected-pharmaceuticals-and-estrogens-from-aqueous-samples
#16
Florian Meischl, Christian G Kirchler, Stefan E Stuppner, Matthias Rainer
This study reports the syntheses of four polymeric sorbents based on nucleophilic substitution of Poly(4-vinylbenzylchloride/ethylene glycol dimethacrylate). Polymerization was executed by a simple thermal initiated bulk polymerization procedure. Ground polymer particles were functionalized through reaction with the nucleophiles triethylamine, imidazole, piperidine and pyrrolidine. Mixed-mode phases were characterized by infrared spectroscopy, nitrogen sorption porosimetry and potentiometric titration for determination of chloride content...
May 9, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29792845/current-frontline-endocrine-treatment-options-for-women-with-hormone-receptor-positive-human-epidermal-growth-factor-receptor-2-her2-negative-advanced-stage-breast-cancer
#17
REVIEW
Hikmat N Abdel-Razeq
Despite the recent advances in breast cancer early detection and awareness, a significant portion of patients present with an advanced-stage disease and more patients will progress to stage IV despite adequate treatment of their initial early-stage disease. Hormone receptor (HR)-positive, Human Epidermal Growth Factor Receptor-2 (HER2)-negative subtype is the commonest among all breast cancer subtypes. The management of the advanced-stage disease of this subtype has evolved significantly over the past few years...
May 19, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29789996/prevalence-and-treatment-of-central-hypogonadism-and-hypoandrogenism-in-women-with-hypopituitarism
#18
Catharina Olivius, Kerstin Landin-Wilhelmsen, Daniel S Olsson, Gudmundur Johannsson, Åsa Tivesten
PURPOSE: Women with hypopituitarism have increased morbidity and mortality, and hypogonadism has been suggested to be a contributing mechanism. The purpose of this study was to investigate the prevalence of central hypogonadism and hypoandrogenism in women with hypopituitarism at a single Swedish center. METHODS: All consecutive women (n = 184) who commenced growth hormone (GH) replacement therapy at Sahlgrenska University Hospital in Gothenburg between 1995 and 2015 were included...
May 22, 2018: Pituitary
https://www.readbyqxmd.com/read/29784737/nccn-guidelines-updates-breast-cancer
#19
Sharon H Giordano, Anthony D Elias, William J Gradishar
The emergence of CDK4/6 inhibitors has changed the treatment algorithm for advanced/metastatic estrogen receptor-positive breast cancer. In pivotal trials of palbociclib, ribociclib, and abemaciclib, doubling in progression-free survival has been seen. All 3 agents in this class are now included in the NCCN Guidelines for Breast Cancer, and clinicians should be incorporating these agents into their treatment algorithms. The other important issue in this breast cancer setting is extended duration of endocrine therapy...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29781235/most-patients-are-eligible-for-an-alternative-to-conventional-whole-breast-irradiation-for-early-stage-breast-cancer-a-national-cancer-database-analysis
#20
Ehsan H Balagamwala, Bindu V Manyam, Charles Marc Leyrer, Naveen Karthik, Timothy Smile, Rahul D Tendulkar, Sheen Cherian, Diane Radford, Zahraa Al-Hilli, Frank Vicini, Chirag Shah
We evaluated the proportion of patients eligible for alternatives to standard whole breast irradiation (WBI) following breast-conserving surgery using the National Cancer Database (NCDB). Using the 2016 dataset, Stage I-III patients were identified. Eligibility for hypofractionated WBI (HFRT), accelerated partial breast irradiation (APBI) and endocrine therapy (ET-alone) was defined using eligibility from large clinical trials as well as consensus guidelines. For patients with pN0 breast cancer, 20.6% and 37...
May 20, 2018: Breast Journal
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