keyword
https://read.qxmd.com/read/38544442/pembrolizumab-induced-type-1-diabetes-mellitus-in-a-patient-with-metastatic-melanoma-and-literature-review-on-steroids-as-a-treatment-option
#1
JOURNAL ARTICLE
Adina Greene, Scott Penner, Jacqueline Kunesh, Amal Altaf, William McGrade, Jiaxin Niu
OBJECTIVE: We report a case of a 77-year-old male with metastatic melanoma who developed immune-checkpoint-inhibitor (ICI) induced type 1 diabetes mellitus (T1DM) after seven months of pembrolizumab treatment and required life-long insulin use. This prompted a literature review of best practice guidelines for long-term management of checkpoint-inhibitor induced T1DM including oral steroids as a treatment option similar to other ICI adverse effects. DATA SOURCES AND SUMMARY: A literature search on PubMed was conducted to evaluate the efficacy of steroid treatment ICI-induced T1DM in any cancer type...
March 28, 2024: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/38541997/reducing-the-risk-of-pre-eclampsia-in-women-with-polycystic-ovary-syndrome-using-a-combination-of-pregnancy-screening-lifestyle-and-medical-management-strategies
#2
REVIEW
Jim Parker, Claire O'Brien, Christabelle Yeoh, Felice L Gersh, Shaun Brennecke
Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with a variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms and signs. Women with PCOS are at increased risk of pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labor, and pre-eclampsia (PE). This may be attributed to the presence of specific susceptibility features associated with PCOS before and during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), and hyperandrogenism, all of which have been associated with an increased risk of pregnancy complications...
March 20, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#3
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38536829/the-effects-of-gases-from-food-waste-on-human-health-a-systematic-review
#4
JOURNAL ARTICLE
Paulina Rudziak, Evans Batung, Isaac Luginaah
Food waste is a routine and increasingly growing global concern that has drawn significant attention from policymakers, climate change activists and health practitioners. Amid the plurality of discourses on food waste-health linkages, however, the health risks from food waste induced emissions have remained under explored. This lack of evidence is partly because of the lack of complete understanding of the effects of food waste emissions from household food waste on human health either directly through physiological mechanisms or indirectly through environmental exposure effects...
2024: PloS One
https://read.qxmd.com/read/38535916/advancing-endocrine-disruptors-via-in-vitro-evaluation-recognizing-the-significance-of-the-organization-for-economic-co-operation-and-development-and-united-states-environmental-protection-agency-guidelines-embracing-new-assessment-methods-and-the-urgent-need
#5
REVIEW
Sophie Fouyet, Marie-Caroline Ferger, Pascale Leproux, Patrice Rat, Mélody Dutot
Efforts are being made globally to improve the evaluation and understanding of endocrine-disrupting chemicals. Recognition of their impact on human health and the environment has stimulated attention and research in this field. Various stakeholders, including scientists, regulatory agencies, policymakers, and industry representatives, are collaborating to develop robust methodologies and guidelines for assessing these disruptors. A key aspect of these efforts is the development of standardized testing protocols and guidelines that aim to provide consistent and reliable methods for identifying and characterizing endocrine disruptors...
February 28, 2024: Toxics
https://read.qxmd.com/read/38533871/-not-available
#6
JOURNAL ARTICLE
Christina Annette Bjerre, Jeanette Dupont Rønlev, Ann Søegaard Knop
Adjuvant and neoadjuvant therapy of early breast cancer reduces the risk of relapse and breast cancer mortality. Treatment modalities include chemotherapy, endocrine therapy, human epidermal growth factor receptor 2-targeted agents, bisphosphonates, immunotherapy, cyclin-dependent kinase inhibitors 4/6- and poly-ADP-ribose polymerase inhibitors. All cases are reviewed at multidisciplinary breast cancer tumour boards. An individualized risk stratification model is applied in this review to optimize the risk-benefit ratio for each patient, and shared decision-making is an integrated part of (neo)adjuvant therapy...
March 18, 2024: Ugeskrift for Laeger
https://read.qxmd.com/read/38533291/accuracy-of-a-non-invasive-home-glucose-monitor-for-measurement-of-blood-glucose
#7
JOURNAL ARTICLE
Himel Mondal, Sairavi Kiran Biri, Neha Pipil, Shaikat Mondal
INTRODUCTION: Patients with diabetes mellitus monitor their blood glucose at home with monitors that require a drop of blood or use a continuous glucose monitoring device that implants a small needle in the body. However, both cause discomfort to the patients which may inhibit them for regular blood glucose checks. Photoplethysmogram (PPG) sensing technology is an approach for non-invasive blood glucose measurement and PPG sensors can be used to predict hypoglycaemic episodes. InChcek is a PPG-based non-invasive glucose monitor...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38529399/overlapping-action-of-t-3-and-t-4-during-xenopus-laevis-development
#8
JOURNAL ARTICLE
Alicia Tribondeau, David Du Pasquier, Médine Benchouaia, Corinne Blugeon, Nicolas Buisine, Laurent M Sachs
Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However, compounds called endocrine disruptors can alter thyroid hormone signaling and induce unwanted effects on human and ecosystems health. Regulatory tests have been developed to detect these compounds but need to be significantly improved by proposing novel endpoints and key events. The Xenopus Eleutheroembryonic Thyroid Assay (XETA, OECD test guideline no. 248) is one such test. It is based on Xenopus laevis tadpoles, a particularly sensitive model system for studying the physiology and disruption of thyroid hormone signaling: amphibian metamorphosis is a spectacular (thus easy to monitor) life cycle transition governed by thyroid hormones...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529392/the-thrombotic-risk-in-cushing-s-syndrome-questions-answers-and-the-algorithm-to-consider-in-its-assessment-part-i-thrombotic-risk-not-related-to-surgery
#9
REVIEW
Agata Hanna Bryk-Wiązania, Mari Minasyan, Renata Świątkowska-Stodulska, Anetta Undas, Alicja Hubalewska-Dydejczyk, Susan M Webb, Elena Valassi, Aleksandra Gilis-Januszewska
INTRODUCTION: Recently, it has been reported that there is a great diversity in strategies used for thromboprophylaxis in patients with Cushing's syndrome (CS). An aim of this review was to discuss these practices in light of the existing data on the thrombotic risk in patients with CS and guidelines for medically ill patients. METHODS: The four relevant topics and questions on thrombotic risk in CS were identified. The current guidelines on prevention and diagnosis of venous thromboembolism (VTE) were reviewed for the answers...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38523848/a-rare-case-of-persistent-multifocal-cribriform-morular-thyroid-carcinoma
#10
William Kuenstner, Po Zhao, Wen Lee, Carlos Garcia, Kenneth D Burman, Leila Shobab
BACKGROUND/OBJECTIVE: Cribriform-morular thyroid carcinoma (CMTC) was considered a variant of papillary thyroid carcinoma (PTC) but is a separate entity in the 2022 World Health Organization classification. CMTC has an association with familial adenomatous polyposis (FAP). Our objective is to report a case of CMTC who was subsequently diagnosed with FAP, to highlight these associated entities and implications for management. CASE REPORT: A 15-year-old female with a history of iron-deficiency anemia and alpha-gal syndrome presented with several years of goiter and dysphagia...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38520603/validity-of-montreal-cognitive-assessment-to-detect-cognitive-impairment-in-individuals-with-type-2-diabetes
#11
JOURNAL ARTICLE
Anu Gupta, Alpesh Goyal, Roopa Rajan, Venugopalan Y Vishnu, Mani Kalaivani, Nikhil Tandon, Madakasira V P Srivastava, Yashdeep Gupta
INTRODUCTION: Guidelines recommend screening older people (> 60-65 years) with type 2 diabetes (T2D) for cognitive impairment, as it has implications in the management of diabetes. The Montreal Cognitive Assessment (MoCA) is a sensitive test for the detection of mild cognitive impairment (MCI) in the general population, but its validity in T2D has not been established. METHODS: We administered MoCA to patients with T2D (age ≥ 60 years) and controls (no T2D), along with a culturally validated neuropsychological battery and functional activity questionnaire...
March 23, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38520602/the-why-what-and-where-podcast-on-the-updated-2023-iwgdf-guideline-on-offloading-treatments-for-diabetes-related-foot-ulcers
#12
JOURNAL ARTICLE
Sicco A Bus, Peter A Lazzarini
In this podcast the lead authors of the 2023 International Working Group on the Diabetic Foot (IWGDF) guideline on offloading treatments for diabetes-related foot ulcers briefly discuss why we need offloading treatments for people with diabetes-related foot ulcers, what the new international offloading guideline recommends, and where offloading treatment might go into the future.A podcast audio is available with this article.
March 23, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38517760/society-for-ambulatory-anesthesia-updated-consensus-statement-on-perioperative-blood-glucose-management-in-adult-patients-with-diabetes-mellitus-undergoing-ambulatory-surgery
#13
JOURNAL ARTICLE
Niraja Rajan, Elizabeth W Duggan, Basem B Abdelmalak, Steven Butz, Leopoldo V Rodriguez, Mary Ann Vann, Girish P Joshi
WHAT OTHER GUIDELINES ARE AVAILABLE ON THIS TOPIC: Since the publication of the SAMBA Consensus Statement for perioperative blood glucose management in the ambulatory setting in 2010, several recent guidelines have been issued by the American Diabetes Association (ADA), the American Association of Clinical Endocrinologists (AACE), the Endocrine Society, the Centre for Perioperative Care (CPOC), and the Association of Anaesthetists of Great Britain and Ireland (AAGBI) on DM care in hospitalized patients; however, none are specific to ambulatory surgery...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38516249/quality-of-life-after-pancreatic-surgery
#14
JOURNAL ARTICLE
Shi-Zhen Li, Ting-Ting Zhen, Yi Wu, Min Wang, Ting-Ting Qin, Hang Zhang, Ren-Yi Qin
BACKGROUND: Pancreatic surgery is challenging owing to the anatomical characteristics of the pancreas. Increasing attention has been paid to changes in quality of life (QOL) after pancreatic surgery. AIM: To summarize and analyze current research results on QOL after pancreatic surgery. METHODS: A systematic search of the literature available on PubMed and EMBASE was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
February 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38513362/discontinuation-of-long-term-gh-treatment-in-adults-with-gh-deficiency-a-survey-of-uk-practice
#15
JOURNAL ARTICLE
Sherwin Criseno, Helena Gleeson, Andrew A Toogood, Neil J Gittoes, Annie Topping, Niki Karavitaki
OBJECTIVE: We conducted a survey of UK endocrine clinicians between 06/2022 and 08/2022 to understand current practices regarding GH treatment discontinuation in adults with GH deficiency (GHD). DESIGN AND METHODS: Using Survey Monkey®, a web-based multiple-choice questionnaire was disseminated to the UK Society for Endocrinology membership. It consisted of 15 questions on demographics, number of patients receiving GH and current practice on GH treatment discontinuation...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513355/value-of-follow-up-diagnostic-radioiodine-scans-in-differentiated-thyroid-cancer
#16
JOURNAL ARTICLE
Teresa Kraus, Natalia Shengelia-de Lange, Holger Einspieler, Marcus Hacker, Alexander Haug, Elisabeth Kretschmer-Chott, Georgios Karanikas
BACKGROUND: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO) the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine Whole Body Scan (WBS) if non-stimulated Tg is greater than 10ng/mL or if Tg is rising...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38510699/quantitative-susceptibility-mapping-for-iron-monitoring-of-multiple-subcortical-nuclei-in-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#17
Sana Mohammadi, Sadegh Ghaderi, Fatemeh Sayehmiri, Mobina Fathi
INTRODUCTION: Iron accumulation in the brain has been linked to diabetes, but its role in subcortical structures involved in motor and cognitive functions remains unclear. Quantitative susceptibility mapping (QSM) allows the non-invasive quantification of iron deposition in the brain. This systematic review and meta-analysis examined magnetic susceptibility measured by QSM in the subcortical nuclei of patients with type 2 diabetes mellitus (T2DM) compared with controls. METHODS: PubMed, Scopus, and Web of Science databases were systematically searched [following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines] for studies reporting QSM values in the deep gray matter (DGM) regions of patients with T2DM and controls...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38510698/adults-with-excess-weight-or-obesity-but-not-with-overweight-report-greater-pain-intensities-than-individuals-with-normal-weight-a-systematic-review-and-meta-analysis
#18
Miguel M Garcia, Patricia Corrales, Miguel Á Huerta, Maciej J Czachorowski, Visitación López-Miranda, Gema Medina-Gómez, Enrique J Cobos, Carlos Goicoechea, Miguel Molina-Álvarez
CONTEXT: Over 1.9 billion adult people have overweight or obesity. Considered as a chronic disease itself, obesity is associated with several comorbidities. Chronic pain affects approximately 60 million people and its connection with obesity has been displayed in several studies. However, controversial results showing both lower and higher pain thresholds in subjects with obesity compared to individuals with normal weight and the different parameters used to define such association (e...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38509509/grade-adolopment-of-hyperthyroidism-treatment-guidelines-for-a-pakistani-context
#19
JOURNAL ARTICLE
Russell Seth Martins, Sarah Nadeem, Abeer Aziz, Sajjan Raja, Alina Pervez, Najmul Islam, Asma Ahmed, Aisha Sheikh, Saira Furqan, Nanik Ram, Azra Rizwan, Nashia Ali Rizvi, Mohsin Ali Mustafa, Salima Saleem Aamdani, Bushra Ayub, Muhammad Qamar Masood
INTRODUCTION: The prevalence of hyperthyroidism in Pakistan is 2.9%, which is two times higher than in the United States. Most high-quality hyperthyroidism clinical practice guidelines (CPGs) used internationally originate from high-income countries in the West. Local CPGs in Pakistan are not backed by transparent methodologies. We aimed to produce comprehensive, high-quality CPGs for the management of hyperthyroidism in Pakistan. METHODS: We employed the GRADE-ADOLOPMENT approach utilizing the 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis as the source CPG...
March 21, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38509442/podcast-on-how-to-classify-foot-ulcers-in-people-with-diabetes-2023-update-of-the-iwgdf-guidelines-on-classification
#20
JOURNAL ARTICLE
Matilde Monteiro-Soares, Fran Game
INTRODUCTION: In this podcast, we present the result of the 2023 scheduled update of the 2019 guidelines of the International Working Group of the Diabetic Foot (IWGDF) addressing the use of systems to classify foot ulcers in people with diabetes in routine clinical practice. METHODS: These guidelines were based on a systematic review of the available literature that identified 28 classifications addressed in 149 articles and, subsequently, expert opinion using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology...
March 21, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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