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https://www.readbyqxmd.com/read/28435102/simultaneous-time-interleaved-multislice-stims-for-rapid-susceptibility-weighted-acquisition
#1
Berkin Bilgic, Huihui Ye, Lawrence L Wald, Kawin Setsompop
T2⁎ weighted 3D Gradient Echo (GRE) acquisition is the main sequence used for Susceptibility Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM). These applications require a long echo time (TE) to build up phase contrast, requiring a long repetition time (TR), and leading to excessively lengthy scans. The long TE acquisition creates a significant amount of unused time within each TR, which can be utilized for either multi-echo sampling or additional image encoding with the echo-shift technique...
April 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28435096/improving-automated-multiple-sclerosis-lesion-segmentation-with-a-cascaded-3d-convolutional-neural-network-approach
#2
Sergi Valverde, Mariano Cabezas, Eloy Roura, Sandra González-Villà, Deborah Pareto, Joan C Vilanova, Lluís Ramió-Torrentà, Àlex Rovira, Arnau Oliver, Xavier Lladó
In this paper, we present a novel automated method for White Matter (WM) lesion segmentation of Multiple Sclerosis (MS) patient images. Our approach is based on a cascade of two 3D patch-wise convolutional neural networks (CNN). The first network is trained to be more sensitive revealing possible candidate lesion voxels while the second network is trained to reduce the number of misclassified voxels coming from the first network. This cascaded CNN architecture tends to learn well from a small (n≤35) set of labeled data of the same MRI contrast, which can be very interesting in practice, given the difficulty to obtain manual label annotations and the large amount of available unlabeled Magnetic Resonance Imaging (MRI) data...
April 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28434111/idh-mutation-and-1p19q-codeletion-distinguish-two-radiological-patterns-of-diffuse-low-grade-gliomas
#3
Amélie Darlix, Jérémy Deverdun, Nicolas Menjot de Champfleur, Florence Castan, Sonia Zouaoui, Valérie Rigau, Michel Fabbro, Yordanka Yordanova, Emmanuelle Le Bars, Luc Bauchet, Catherine Gozé, Hugues Duffau
Diffuse low-grade gliomas (DLGG) prognosis is variable, depending on several factors, including the isocitrate dehydrogenase (IDH) mutation and the 1p19q codeletion. A few studies suggested associations between these parameters and tumor radiological characteristics including topography. Our aim was analyzing the correlations between the IDH and 1p19q statuses and the tumor intracerebral distribution (at the lobar and voxel levels), volume, and borders. We conducted a retrospective, monocentric study on a consecutive series of 198 DLGG patients...
April 22, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28428207/mr-imaging-grading-system-for-skull-base-chordoma
#4
K Tian, L Wang, J Ma, K Wang, D Li, J Du, G Jia, Z Wu, J Zhang
BACKGROUND AND PURPOSE: Skull base chordoma has been widely studied in recent years, however, imaging characteristics of this tumor have not been well elaborated. The purpose of this study was to establish an MR imaging grading system for skull base chordoma. MATERIALS AND METHODS: In this study, 156 patients with skull base chordomas were retrospectively assessed. Tumor-to-pons signal intensity ratios were calculated from pretreatment MR images RT1 (ratio of tumor to pons signal intensity in T1 FLAIR sequence), RT2 (ratio of tumor to pons signal intensity in T2 sequence) and REN (ratio of tumor to pons signal intensity in enhanced T1 FLAIR sequence), and significant ratios for overall survival and progression-free survival were selected to establish a grading system...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28427705/presence-of-central-veins-and-susceptibility-weighted-imaging-for-evaluating-lesions-in-multiple-sclerosis-and-leukoaraiosis
#5
Urška Lamot, Jernej Avsenik, Saša Šega, Katarina Šurlan Popovič
PURPOSE: The process of demyelination in multiple sclerosis (MS) is reflected in lesions of the central nervous system (CNS), which are found in an abundance of different diseases and are frequently radiographically indistinguishable. Our aim was to determine whether the perivenous distribution of MS lesions identified on susceptibility weighted images (SWI) could be used as a specific radiographic sign for MS, and also to determine whether the visibility of the central vein (CV) is affected by the activity of MS lesions...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28427164/early-tumour-shrinkage-as-a-survival-predictor-in-patients-with-recurrent-glioblastoma-treated-with-bevacizumab-in-the-avareg-randomized-phase-ii-study
#6
Alba A Brandes, Gaetano Finocchiaro, Vittorina Zagonel, Michele Reni, Alessandra Fabi, Claudia Caserta, Alicia Tosoni, Marica Eoli, Giuseppe Lombardi, Matteo Clavarezza, Alexandro Paccapelo, Stefania Bartolini, Luigi Cirillo, Raffaele Agati, Enrico Franceschi
BACKGROUND: Disease assessment for recurrent glioblastoma (GBM) represents a challenge, especially with the use of antiangiogenic agents. Moreover, validated neuroradiological predictors of outcome are lacking. Recently, the concept of early tumor shrinkage (ETS) has been developed to better assess the ability of treatments in determining a rapid and remarkable tumor response.The aim of the study was to evaluate the role of ETS in predicting survival of GBM patients treated with BEVMETHODS: We examined the radiological data of patients with recurrent GBM treated with bevacizumab (BEV) or fotemustine (FTM) in the randomized phase II AVAREG trial (EudraCT: 2011-001363-46)...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28425349/clinical-characteristics-of-unknown-symptom-onset-stroke-patients-with-and-without-diffusion-weighted-imaging-and-fluid-attenuated-inversion-recovery-mismatch
#7
Götz Thomalla, Florent Boutitie, Jochen B Fiebach, Claus Z Simonsen, Salvador Pedraza, Robin Lemmens, Norbert Nighoghossian, Pascal Roy, Keith W Muir, Martin Ebinger, Ian Ford, Bastian Cheng, Ivana Galinovic, Tae-Hee Cho, Josep Puig, Vincent Thijs, Matthias Endres, Jens Fiehler, Christian Gerloff
Background Diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) mismatch was suggested to identify stroke patients with unknown time of symptom onset likely to be within the time window for thrombolysis. Aims We aimed to study clinical characteristics associated with DWI-FLAIR mismatch in patients with unknown onset stroke. Methods We analyzed baseline MRI and clinical data from patients with acute ischemic stroke proven by DWI from WAKE-UP, an investigator-initiated, randomized, placebo-controlled trial of MRI-based thrombolysis in stroke patients with unknown time of symptom onset...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28425048/biopsy-targeting-with-dynamic-contrast-enhanced-versus-standard-neuronavigation-mri-in-glioma-a-prospective-double-blinded-evaluation-of-selection-benefits
#8
Vera C Keil, Bogdan Pintea, Gerrit H Gielen, Susanne Greschus, Rolf Fimmers, Jürgen Gieseke, Matthias Simon, Hans H Schild, Dariusch R Hadizadeh
Current biopsy planning based on contrast-enhanced T1W (CET1W) or FLAIR sequences frequently delivers biopsy samples that are not in concordance with the gross tumor diagnosis. This study investigates whether the quantitative information of transfer constant K(trans) maps derived from T1W dynamic contrast-enhanced MRI (DCE-MRI) can help enhance the quality of biopsy target selection in glioma. 28 patients with suspected glioma received MRI including DCE-MRI and a standard neuronavigation protocol of 3D FLAIR- and CET1W data sets (0...
April 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28424595/gray-matter-atrophy-is-primarily-related-to-demyelination-of-lesions-in-multiple-sclerosis-a-diffusion-tensor-imaging-mri-study
#9
Eszter Tóth, Nikoletta Szabó, Gergõ Csete, András Király, Péter Faragó, Tamás Spisák, Krisztina Bencsik, László Vécsei, Zsigmond T Kincses
Objective: Cortical pathology, periventricular demyelination, and lesion formation in multiple sclerosis (MS) are related (Hypothesis 1). Factors in the cerebrospinal fluid close to these compartments could possibly drive the parallel processes. Alternatively, the cortical atrophy could be caused by remote axonal transection (Hypothesis 2). Since MRI can differentiate between demyelination and axon loss, we used this imaging modality to investigate the correlation between the pattern of diffusion parameter changes in the periventricular- and deep white matter and the gray matter atrophy...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28419602/physics-for-clinicians-fluid-attenuated-inversion-recovery-flair-and-double-inversion-recovery-dir-imaging
#10
REVIEW
Manojkumar Saranathan, Pauline W Worters, Dan W Rettmann, Blair Winegar, Jennifer Becker
A pedagogical review of fluid-attenuated inversion recovery (FLAIR) and double inversion recovery (DIR) imaging is conducted in this article. The basics of the two pulse sequences are first described, including the details of the inversion preparation and imaging sequences with accompanying mathematical formulae for choosing the inversion time in a variety of scenarios for use on clinical MRI scanners. Magnetization preparation (or T2prep), a strategy for improving image signal-to-noise ratio and contrast and reducing T1 weighting at high field strengths, is also described...
April 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28418275/factors-influencing-cochlear-patency-after-translabyrinthine-surgery
#11
Brian Rodgers, Emily Stucken, Aaron Metrailer, Eric Sargent
Objective To determine predictive factors for cochlear obliteration after translabyrinthine surgery for vestibular schwannoma. Study Design Case series with chart review. Setting Neurotology referral center. Subjects and Methods In total, 345 charts were reviewed, resulting in 103 patients who underwent translabyrinthine surgery between January 2010 and July 2015 and had postoperative magnetic resonance imaging (MRI) for review. Surveillance MRI performed after translabyrinthine resection of vestibular schwannomas was reviewed...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28414663/not-another-acs-rule-out
#12
S Preston, R Nelson, M Watts, D Smith, T Dewenter, D Spruill
CASE: A 50 year old African-American woman with diabetes, hypertension, and hyperlipidemia presented with progressively worsening retro-sternal chest pain, exacerbated by activity and relieved by rest. She also endorsed a thirty-pound unintentional weight loss, and dysphagia. She was dysarthric with left-sided Bell's Palsy and a palpable left axillary lymph node. She had been evaluated at several hospitals in the previous months for similar typical chest pain. Her troponin values were normal, and an EKG showed T-wave inversions in leads I and aVL...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413401/parkinsonism-in-association-with-dihydropteridine-reductase-deficiency
#13
Yoshiaki Takahashi, Yasuhiro Manabe, Yumiko Nakano, Taijun Yunoki, Syoichiro Kono, Hisashi Narai, Mahoko Furujo, Koji Abe
We report a 16-year-old man with disorders of tetrahydrobiopterin metabolism due to dihydropteridine reductase (DHPR) deficiency. He revealed moderate mental retardation, parkinsonism, and spastic paralysis with levodopa and 5-hydroxytryptophan (5-HTP) supplementation from the age of 2 months. Brain MRI showed high intensity areas in bilateral frontal and posterior deep white matter on fluid-attenuated inversion recovery (FLAIR). Coronal FLAIR image showed a high signal in bilateral pyramidal tracts. Single photon computed tomography (SPECT) imaging of the dopamine transporter was normal...
January 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28412481/environmental-and-clinical-risk-factors-for-delirium-in-a-neurosurgical-center-a-prospective-study
#14
Fumihiro Matano, Takayuki Mizunari, Keiko Yamada, Shiro Kobayashi, Yasuo Murai, Akio Morita
INTRODUCTION: Few reports of delirium-related risk factors have focused on environmental risk factors and clinical risk factors, such as white matter signal abnormalities on magnetic resonance imaging (MRI) FLAIR images. MATERIAL & METHODS: We prospectively enrolled 253 patients admitted to our neurosurgical center between December 2014 and June 2015 and analyzed a total of 220 patients (100 males; mean age, 64.1 years; age range, 17-92 years). The upper 4 points of the Intensive Care Delirium Screening Checklist (ICDSC) indicated delirium...
April 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28409356/flair-to-visualize-veins-in-white-matter-lesions-a-new-tool-for-the-diagnosis-of-multiple-sclerosis
#15
T Campion, R J P Smith, D R Altmann, G C Brito, B P Turner, J Evanson, I C George, P Sati, D S Reich, M E Miquel, K Schmierer
OBJECTIVE: To explore the potential of a post-processing technique combining FLAIR and T2* (FLAIR*) to distinguish between lesions caused by multiple sclerosis (MS) from cerebral small vessel disease (SVD) in a clinical setting. METHODS: FLAIR and T2* head datasets acquired at 3T of 25 people with relapsing MS (pwRMS) and ten with pwSVD were used. After post-processing, FLAIR* maps were used to determine the proportion of white matter lesions (WML) showing the 'vein in lesion' sign (VIL), a characteristic histopathological feature of MS plaques...
April 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28396650/new-onset-refractory-status-epilepticus-with-claustrum-damage-definition-of-the-clinical-and-neuroimaging-features
#16
Stefano Meletti, Giada Giovannini, Giuseppe d'Orsi, Lisa Toran, Giulia Monti, Rahul Guha, Andreas Kiryttopoulos, Maria Grazia Pascarella, Tommaso Martino, Haris Alexopoulos, Martha Spilioti, Jana Slonkova
New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in a previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes in a group of patients with NORSE who all demonstrated a typical magnetic resonance imaging (MRI) sign characterized by bilateral lesions of the claustrum. The group includes 31 patients (12 personal and 19 previously published cases; 17 females; mean age of 25 years). Fever preceded status epilepticus (SE) in 28 patients, by a mean of 6 days...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28395426/-analysis-of-the-clinical-features-of-vestibular-migraine-with-mri-changes
#17
F Qiu, D D Song, Q F Guo, Q Q Wang, Z W Wang, J G Liu, Y Y Wang, X K Qi
Objective: To investigate the clinical features of vestibular migraine with MRI changes. Methods: The clinical data of 150 patients with vestibular migraine completing MRI examination in navy general hospital from August 2008 to August 2016 were retrospectively analyzed.Clinical features of 94 (62.7%) vestibular migraine patients with MRI changes were collected and analyzed according to the medical history, clinical symptoms and signs, as well as the result of auxiliary examinations. Results: The manifestations of MRI in vestibular migraine patients were mainly multiple punctate equal T(1) and long T(2) signals or high signals on FLAIR (fluid attenuated inversion recovery) in subcortical white matter...
April 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28391601/retrospective-evaluation-of-cerebral-tumors-resect-a-clinical-database-of-pre-operative-mri-and-intra-operative-ultrasound-in-low-grade-glioma-surgeries
#18
Yiming Xiao, Maryse Fortin, Geirmund Unsgård, Hassan Rivaz, Ingerid Reinertsen
PURPOSE: The advancement of medical image processing techniques, such as image registration, can effectively help improve the accuracy and efficiency of brain tumor surgeries. However, it is often challenging to validate these techniques with real clinical data due to the rarity of such publicly available repositories. ACQUISITION AND VALIDATION METHODS: Pre-operative magnetic resonance images (MRI), and intra-operative ultrasound (US) scans were acquired from 23 patients with low-grade glioma who underwent surgeries at St...
April 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28386807/acute-human-herpes-virus-7-hhv-7-encephalitis-in-an-immunocompetent-adult-patient-a-case-report-and-review-of-literature
#19
Nicoletta Riva, Iacopo Franconi, Marianna Meschiari, Erica Franceschini, Cinzia Puzzolante, Gianluca Cuomo, Alessandro Bianchi, Francesca Cavalleri, Maurilio Genovese, Cristina Mussini
We report a case of an acute HHV-7 encephalitis involving the nucleus of the VI cranial nerve in an immunocompetent host. The patient was an adult male admitted to our Clinic with headache, diplopia, fever, nausea, vertigo, asthenia and general malaise. PCR for viral and bacterial genomes was run on both serum and cerebral spinal fluid (CSF) after performing lumbar puncture, resulting positive only for HHV-7 DNA on CSF. MRI showed hyperintensity in FLAIR signal in the dorsal pons, in the area of the VI cranial nerve nucleus...
April 6, 2017: Infection
https://www.readbyqxmd.com/read/28386689/corpus-callosum-involvement-a-useful-clue-for-differentiating-fabry-disease-from-multiple-sclerosis
#20
Sirio Cocozza, Gaia Olivo, Eleonora Riccio, Camilla Russo, Giuseppe Pontillo, Lorenzo Ugga, Silvia Migliaccio, Dario de Rosa, Sandro Feriozzi, Massimiliano Veroux, Yuri Battaglia, Daniela Concolino, Federico Pieruzzi, Antonino Tuttolomondo, Aurelio Caronia, Cinzia Valeria Russo, Roberta Lanzillo, Vincenzo Brescia Morra, Massimo Imbriaco, Arturo Brunetti, Enrico Tedeschi, Antonio Pisani
PURPOSE: Multiple sclerosis (MS) has been proposed as a possible differential diagnosis for Fabry disease (FD). The aim of this work was to evaluate the involvement of corpus callosum (CC) on MR images and its possible role as a radiological sign to differentiate between FD and MS. METHODS: In this multicentric study, we retrospectively evaluated the presence of white matter lesions (WMLs) on the FLAIR images of 104 patients with FD and 117 patients with MS. The incidence of CC-WML was assessed in the two groups and also in a subgroup of 37 FD patients showing neurological symptoms...
April 6, 2017: Neuroradiology
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