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https://www.readbyqxmd.com/read/29784673/formation-of-the-sacrum-requires-down-regulation-of-sonic-hedgehog-signaling-in-the-sacral-intervertebral-discs
#1
Raffaella Bonavita, Kathleen Vincent, Robert Pinelli, Chitra Lekha Dahia
In humans, the sacrum forms an important component of the pelvic arch, and it transfers the weight of the body to the lower limbs. The sacrum is formed by collapse of the intervertebral discs (IVDs) between the five sacral vertebrae during childhood, and their fusion to form a single bone. We show that collapse of the sacral discs in the mouse is associated with the down-regulation of sonic hedgehog (SHH) signaling in the nucleus pulposus (NP) of the disc, and many aspects of this phenotype can be reversed by experimental postnatal activation of HH signaling...
May 21, 2018: Biology Open
https://www.readbyqxmd.com/read/29776816/patterns-and-associations-of-structural-and-functional-cutaneous-responses-during-loading-at-heel-and-sacral-skin-in-aged-females-a-reanalysis-of-clinical-study-data
#2
Eva K B Pfannes, Ulrike Blume-Peytavi, Jan Kottner
AIM OF THE STUDY: The aim of this study was to explore possible interrelationships and cutaneous response patterns at the heel and sacral skin due to prolonged loading. MATERIALS AND METHODS: Skin stiffness, elasticity, roughness and transepidermal water loss, stratum corneum hydration, erythema, and temperature of n = 20 aged females (mean age 69.9 years) were measured before and after 90 and 150 min loading in supine position. Delta values were calculated and correlated using Spearman's rho...
May 10, 2018: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29774198/a-rare-cause-of-thoracic-spinal-cord-compression-by-multiple-large-tarlov-cysts
#3
Ahmed-Salem Kleib, Sidi-Mohamed Salihy, Hussein Hamdi, Romain Carron, Outouma Soumaré
Spinal extradural arachnoid cyst (SEAC) is a rare cause of spinal cord compression. Bifocal location of thoracic and sacral SEACs is rarely reported in the literature. We report a case of thoracic spinal cord compression by SEAC associated with asymptomatic multiple sacral Tarlov cysts (TC). The surgical management and postoperative outcome of the patient are discussed. A 34-year-old woman was referred to the hospital for acute thoracic pain with a history of chronic long-standing back pain. She complained of walking difficulties...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29773438/the-relationship-of-subepidermal-moisture-and-early-stage-pressure-injury-by-visual-skin-assessment
#4
Chul-Gyu Kim, Seungmi Park, Ji Woon Ko, Sungho Jo
AIM: The purpose of this study was to examine the relationship of subepidermal moisture and early stage pressure injury by visual skin assessment in elderly Korean. METHODS: Twenty-nine elderly participated at a particular nursing home. Data were collected for 12 weeks by one wound care nurse. Visual skin assessment and subepidermal moisture value were measured at both buttocks, both ischia, both trochanters, sacrum, and coccyx of each subject once a week. RESULTS: Subepidermal moisture value of stage 1 pressure injury was significantly higher than that of no injury and blanching erythema...
May 8, 2018: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29761492/c7-vertebra-homeotic-transformation-in-domestic-dogs-are-pug-dogs-breaking-mammalian-evolutionary-constraints
#5
J Brocal, S De Decker, R José-López, E G Manzanilla, J Penderis, C Stalin, S Bertram, J J Schoenebeck, C Rusbridge, N Fitzpatrick, R Gutierrez-Quintana
The number of cervical vertebrae in mammals is almost constant at seven, regardless of their neck length, implying that there is selection against variation in this number. Homebox (Hox) genes are involved in this evolutionary mammalian conservation, and homeotic transformation of cervical into thoracic vertebrae (cervical ribs) is a common phenotypic abnormality when Hox gene expression is altered. This relatively benign phenotypic change can be associated with fatal traits in humans. Mutations in genes upstream of Hox, inbreeding and stressors during organogenesis can also cause cervical ribs...
May 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29760871/presacral-myelolipoma-as-a-possible-parasymptom-of-cancer-a-case-report
#6
Akio Sakamoto, Iori Nagamatsu, Eisuke Shiba, Takeshi Okamoto, Masanori Hisaoka, Shuichi Matsuda
Presacral myelolipomas are rare, benign, asymptomatic tumors composed of mature adipose tissue and hematopoietic elements. Presacral myelolipomas can occur in patients with a medical history of malignancy, steroid use, and/or endocrine disorders including diabetes mellitus. A 65-year-old man with no specific medical history experienced temporal abdominal pain without bowel symptoms that lasted a few hours. By the time he visited a hospital, the pain had diminished. Computed tomography failed to detect any abnormality in the abdominal or pelvic organs that would have caused the abdominal pain but revealed a lesion 4 cm in diameter in the frontal sacrum...
2018: Rare Tumors
https://www.readbyqxmd.com/read/29759930/diagnostic-criteria-for-camptocormia-in-parkinson-s-disease-a-consensus-based-proposal
#7
Alfonso Fasano, Christian Geroin, Alfredo Berardelli, Bastiaan R Bloem, Alberto J Espay, Mark Hallett, Anthony E Lang, Michele Tinazzi
INTRODUCTION: Camptocormia is defined as an involuntary, marked flexion of the thoracolumbar spine appearing during standing or walking and resolving in the supine position or when leaning against a wall. However, there is no established agreement on the minimum degree of forward flexion needed to diagnose camptocormia. Likewise, the current definition does not categorize camptocormia on the basis of the bending fulcrum. METHODS: We performed a survey among movement disorders experts to identify camptocormia using images of patients with variable degrees and types of forward trunk flexion by fulcrum (upper and lower fulcra)...
May 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29756474/henna-lawsonia-inermis-as-an-inexpensive-method-to-prevent-decubitus-ulcers-in-critical-care-units-a-randomized-clinical-trial
#8
Davood Hekmatpou, Fatemeh Ahmadian, Maryam Eghbali, Shadi Farsaei
BACKGROUND: Henna has been used to combat various diseases and pathological conditions of the skin. This study aimed to determine the cooling and protecting effects of henna on prevention of decubitus ulcers in critical care units. METHOD: This is a randomized clinical trial. It was conducted on 80 patients hospitalized in intensive care units. Patients were randomly allocated into 2 groups of control and intervention (n = 40) by blocking method. For the intervention group, along with the standard prevention cares for decubitus ulcers, henna was applied with 15 cm extent on the patients' sacrum...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29749378/frequency-and-associated-factors-of-bone-fractures-in-russians-the-ural-eye-and-medical-study
#9
Mukharram M Bikbov, Rinat R Fayzrakhmanov, Gyulli M Kazakbaeva, Rinat M Zainullin, Venera F Salavatova, Timur R Gilmanshin, Inga I Arslangareeva, Nikolai A Nikitin, Songhomitra Panda-Jonas, Svetlana R Mukhamadieva, Dilya F Yakupova, Renat I Khikmatullin, Said K Aminev, Ildar F Nuriev, Artur F Zaynetdinov, Yulia V Uzianbaeva, Jost B Jonas
With information about frequency of bone fractures in Russia mostly missing, we assessed the frequency of previous bone fractures in a Russian population. The population-based study Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals (mean age: 59.0 ± 10.7 years; range: 40-94 years). The history of previous bone fractures was assessed in a standardized interview for 5397 (91.5%) individuals. Mean frequency of any previous bone fracture was 1650/5397 (30.6%; 95% confidence interval (CI): 29, 3, 31...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735137/two-level-osteotomy-for-correcting-severe-ankylosing-spondylitis-kyphosis-radiologic-outcomes-of-different-osteotomy-position-selection-strategy-for-different-type-of-patients
#10
Chao Liu, Guoquan Zheng, Yue Guo, Kai Song, Xiangyu Tang, Xuesong Zhang, Zheng Wang, Yan Wang
OBJECTIVE: To report on the radiologic outcomes of different osteotomy position-selection strategies for a two-level osteotomy for correcting severe ankylosing spondylitis kyphosis. METHODS: From July 2009 to September 2016, a total of 46 patients in our department with severe ankylosing spondylitis kyphosis who underwent two-level pedicle subtraction osteotomy (PSO) were studied. Pre- and postoperative relevant parameters were recorded. The patients were divided into two types and further separated into four groups...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29732516/survival-analysis-of-patients-with-spinal-chordomas
#11
Hui-Hui Sun, Xin Hong, Bing Liu, Jia-Qu Cui, Zhao-Ming Zhou, Xin-Hui Xie, Xiao-Tao Wu
This study was aimed to analyze the survival of patients with spinal chordomas. Patients' data in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved and analyzed statistically. There were 765 patients with spinal chordomas between 1974 and 2013. The overall survival did not improve significantly over decades for patients receiving surgery and radiotherapy (SR) (P = 0.221). There were significant differences in overall survival among subgroups of patients receiving surgery (S), radiotherapy (R), and neither S nor R (NSR) (P = 0...
May 7, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29732434/minimally-invasive-spinal-surgery-for-trauma-a-narrative-review
#12
REVIEW
Dolin Bhagawati, Dimpu Dwijen Bhagawati
Over the past decade there has been a revolution in availability for minimally invasive techniques for the fixation of spinal fractures. In this narrative review we aimed to take a comprehensive look at these developments and their results from the Atlas to the Sacrum establishing the current evidence base for percutaneous fixation at each level of the spine.
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29732421/the-top-50-cited-articles-on-chordomas
#13
Tochukwu Ikpeze, Addisu Mesfin
Background: Chordomas are rare malignant primary tumors of the spine. In the mobile spine and sacrum an en-bloc resection is associated with decreased rates of recurrence. Our objective was to identify the top cited articles in chordoma research and to further analyze characteristics of these articles. Methods: In March 2017, we used ISI Web of Science (v5.11, Thomas Reuter, Philadelphia, Pennsylvania, USA) to search for the following key word: "chordoma"...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29727335/spinopelvic-fixation
#14
Sean M Esmende, Kalpit N Shah, Alan H Daniels
Fixation at the lumbosacral junction continues to be a challenge for spine surgeons despite advances in spinal instrumentation techniques. The poor bone quality of the sacrum, the complex regional anatomy, and the tremendous biomechanical forces at the lumbosacral junction contribute to the high rates of instrumentation-related complications. Although many spinopelvic fixation techniques have been reported, only a few are still widely used because of the high complication rates associated with previous techniques...
June 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29718014/linear-terra-firma-forme-dermatosis-of-the-midline-back
#15
Benjamin D Freemyer, Michael R Migden, Sirunya Silapunt
Terra firma-forme dermatosis (TFFD) is a benign and likely underdiagnosed disorder with relatively few reports in the literature. A 46-year-old woman presented to our clinic with a 3-year history of linear TFFD extending from the upper sacrum to the midline upper back. It initially was thought to be acanthosis nigricans or lichen simplex chronicus, and a topical steroid cream was applied without success. The lesion ultimately was removed by rubbing with isopropyl alcohol, which confirmed a diagnosis of TFFD...
March 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29713738/fetal-median-sacral-artery-anatomy-study-by-micro-ct-imaging
#16
P Meignan, A Binet, A R Cook, H Lardy, G Captier
PURPOSE: The median sacral artery (MSA) is the termination of the dorsal aorta, which undergoes a complex regression and remodeling process during embryo and fetal development. The MSA contributes to the pelvic vascularization and may be injured during pelvic surgery. The embryological steps of MSA development, anastomosis formation and anatomical variations are linked, but not fully understood. METHODS: The pelvic vascularization and more precisely the MSA of a human fetus at 22 weeks of gestation (GW) were studied using micro-CT imaging...
April 30, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29704738/case-report-metastases-in-a-low-stage-middle-graded-hcc-in-cleared-hcv-infection-non-cirrhotic-liver-surgical-therapy
#17
Stefania Brozzetti, Simone Bini, Katia Fazzi, Leonardo Luca Chiarella, Virginia Ceccarossi, Chiara De Lucia, Giorgio De Toma
INTRODUCTION: Hepatocellular carcinoma (HCC) is rare in non-cirrhotic liver. Achievement of sustained virological response (SVR) reduces even more the risk. PRESENTATION OF CASE: Liver resection for small HCC was performed in cleared HCV infection non-cirrhotic 62-year-old man. Methacronous oligometastatic recurrences in intolerant to Nexavar® side-effects patient, were treated by multiple innovative microinvasive approaches: bilateral laparoscopic adrenalectomy, thoracic wall resection, laparoscopic sacrum cryoablation combined with hadron-therapy...
April 22, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29701372/unusual-behavior-of-a-lung-inflammatory-myofibroblastic-tumor-case-report
#18
Cristina Rodrigues, Daniel Cabral, Teresa Almodovar, Analisa Ribeiro, Diogo Delgado, Leonor Mota, Samuel Mendes, Magda Alvoeiro, Carolina Torres, Telma Calado, Mariana Antunes, Francisco Félix
INTRODUCTION: 55 years old, male patient. History of heavy smoking (65 UMA) and COPD. Admitted to hospital due to a left pneumonia. Thoracic CT and PET-Scan, showed left lower lobe mass measuring 92x89 mm (SUVmax 49). Several mediastinal node groups presented increased uptake of FDG. A fiberoptic bronchoscopy was performed. Citology of the bronchoalveolar lavage suggested a squamous carcinoma. EBUS of node stations 4R, 4L e 7 without evidence of malignancy. METHODS: The case was taken to a multidisciplinary meeting staged as IIIA (T3N2M0)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700604/fragility-fractures-of-the-sacrum-occur-in-elderly-patients-with-severe-loss-of-sacral-bone-mass
#19
Daniel Wagner, Alexander Hofmann, Lukas Kamer, Takeshi Sawaguchi, R Geoff Richards, Hansrudi Noser, Dominik Gruszka, Pol M Rommens
INTRODUCTION: Patients suffering from osteoporosis-associated fragility fractures of the sacrum (FFS; also termed sacral insufficiency fractures) are increasingly observed. They have typical fracture patterns with fracture lines located in the sacral ala. When treating these patients operatively, iliosacral screw loosening is not uncommon. We aimed to study the sacral bone mass in patients presenting with a FFS using 3D statistical models. MATERIALS AND METHODS: 3D models of averaged Hounsfield units (HU) were generated based on CT scans from 13 patients with a unilateral FFS (mean age 79...
April 26, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29697533/interleukin-6-trans-signaling-and-pathological-low-back-pain-in-patients-with-paget-s-disease-of-bone
#20
Domenico Rendina, Gianpaolo De Filippo, Loredana Postiglione, Bianca Covelli, Margherita Ricciardone, Séverine Guillaume, Gaetano Di Spigna, Carmine Selleri, Daniela Merlotti, Simone Bianciardi, Maria Materozzi, Riccardo Muscariello, Francesca De Pascale, Lanfranco D'Elia, Ranuccio Nuti, Pasquale Strazzullo, Luigi Gennari
The interleukin (IL)-6 biological system plays a key role in the pathogenesis of Paget's disease of bone (PD) and pathological bone pain. Bone pain, particularly in the lower back region, is the most frequent symptom in patients with PD. This case-control study aimed to evaluate the relationship between the IL-6 system and low back pain (LBP) in patients with PD. We evaluated 85 patients with PD, with the disease localized in the lumbar spine, pelvis, and/or sacrum, and classified them based on the presence or absence of LBP, before and after aminobisphosphonate treatment...
April 23, 2018: Pain
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