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https://www.readbyqxmd.com/read/28938687/mediastinal-lesions-across-the-age-spectrum-a-clinicopathological-comparison-between-pediatric-and-adult-patients
#1
Tingting Liu, Lika'a Fasih Y Al-Kzayer, Xiao Xie, Hua Fan, Shamil Naji Sarsam, Yozo Nakazawa, Lei Chen
The objective of this study was to identify the differences in histopathological distribution and clinical features of mediastinal lesions (MLs) across the age spectrum in Chinese series of patients and to compare with the available literature. A total of 409 cases of MLs, including 137 pediatric and 272 adult patients from a single institution, was reviewed and categorized into groups according to age. Among the 409 cases, the age showed a bimodal distribution with an increased incidence of MLs among (< 10 year) and (60-< 70 year) age groups...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938128/contralateral-axillary-lymph-node-metastasis-in-second-primary-breast-cancer-case-report-and-review-of-the-literature
#2
Jacob Gingerich, Edna Kapenhas, Jack Morgani, Alan Heimann
The rare entity of contra-lateral axillary lymph node metastasis(CAM) has been a debatable topic in the realm of breast cancer management for many years. There remains controversy over whether CAM should be considered distant metastasis or locoregional spread. It is also uncertain why or how CAM occurs. In this case report and review of the literature, we present an 81-year-old female with an apparent second primary breast cancer with synchronous CAM. This paper describes a scenario of altered lymphatic drainage which likely lead to CAM...
August 25, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28938053/persistent-hotspots-of-lymphatic-filariasis-microfilaraemia-despite-14-years-of-mass-drug-administration-in-ghana
#3
Nana-Kwadwo Biritwum, Paul Yikpotey, Benjamin K Marfo, Samuel Odoom, Ernest O Mensah, Odame Asiedu, Bright Alomatu, Edward T Hervie, Abednego Yeboah, Serge Ade, Sven G Hinderaker, Anthony Reid, Kudakwashe C Takarinda, Benjamin Koudou, Joseph B Koroma
Background: Among the 216 districts in Ghana, 98 were declared endemic for lymphatic filariasis in 1999 after mapping. Pursuing the goal of elimination, WHO recommends annual treatment using mass drugs administration (MDA) for at least 5 years. MDA was started in the country in 2001 and reached national coverage in 2006. By 2014, 69 districts had 'stopped-MDA' (after passing the transmission assessment survey) while 29 others remained with persistent microfilaraemia (mf) prevalence (≥1%) despite more than 11 years of MDA and were classified as 'hotspots'...
December 1, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28938025/the-kaposi-s-sarcoma-associated-herpesvirus-kshv-non-structural-membrane-protein-k15-is-required-for-viral-lytic-replication-and-may-represent-a-therapeutic-target
#4
Bizunesh Abere, Tamrat M Mamo, Silke Hartmann, Naira Samarina, Elias Hage, Jessica Rückert, Sven-Kevin Hotop, Guntram Büsche, Thomas F Schulz
Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious cause of the highly vascularized tumor Kaposi's sarcoma (KS), which is characterized by proliferating spindle cells of endothelial origin, extensive neo-angiogenesis and inflammatory infiltrates. The KSHV K15 protein contributes to the angiogenic and invasive properties of KSHV-infected endothelial cells. Here, we asked whether K15 could also play a role in KSHV lytic replication. Deletion of the K15 gene from the viral genome or its depletion by siRNA lead to reduced virus reactivation, as evidenced by the decreased expression levels of KSHV lytic proteins RTA, K-bZIP, ORF 45 and K8...
September 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28937922/a-role-for-near-infrared-fluorescent-imaging-in-the-evaluation-of-lymphatic-function
#5
Stanley G Rockson
No abstract text is available yet for this article.
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28937879/advax4-delta-inulin-combination-adjuvant-together-with-ecmx-a-fusion-construct-of-three-protective-mtb-antigens-induces-a-potent-th1-immune-response-and-protects-mice-against-mycobacterium-tuberculosis-infection
#6
Bruno de Paula Oliveira Santos, Monalisa Martins Trentini, Renato Beilner Machado, Mara Rúbia Nunes Celes, André Kipnis, Nikolai Petrovsky, Ana Paula Junqueira-Kipnis
Tuberculosis (TB) remains a main public health concern and 10.4 million new cases occurred in 2015 around the world. BCG is the only approved vaccine against TB, but has variable efficacy and new vaccines are needed. We developed two new mTB vaccine candidates based on the recombinant fusion proteins, rCMX and rECMXformulated with Advax4, a new combination adjuvant combining delta inulin, CpG oligonucleotide and murabutide. When BALB/c mice were immunized three times intramuscularly with these vaccine formulationsInjection of Advax4 alone increased the percentage of lymphatic endothelial cells and activated macrophages (F480/CD11b(+)) in the draining lymph nodes consistent with a chemotactic adjuvant effect...
September 22, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28935890/demonstration-and-analysis-of-the-suction-effect-for-pumping-lymph-from-tissue-beds-at-subatmospheric-pressure
#7
Samira Jamalian, Mohammad Jafarnejad, Scott D Zawieja, Christopher D Bertram, Anatoliy A Gashev, David C Zawieja, Michael J Davis, James E Moore
Many tissues exhibit subatmospheric interstitial pressures under normal physiologic conditions. The mechanisms by which the lymphatic system extracts fluid from these tissues against the overall pressure gradient are unknown. We address this important physiologic issue by combining experimental measurements of contractile function and pressure generation with a previously validated mathematical model. We provide definitive evidence for the existence of 'suction pressure' in collecting lymphatic vessels, which manifests as a transient drop in pressure downstream of the inlet valve following contraction...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935759/lymphangiogenesis-facilitates-initial-lymph-formation-and-enhances-the-dendritic-cell-mobilizing-chemokine-ccl21-without-affecting-migration
#8
Tine V Karlsen, Tore Reikvam, Anne Tofteberg, Elham Nikpey, Trude Skogstrand, Marek Wagner, Olav Tenstad, Helge Wiig
OBJECTIVE: Lymphatic vessels play an important role in body fluid, as well as immune system homeostasis. Although the role of malfunctioning or missing lymphatics has been studied extensively, less is known on the functional consequences of a chronically expanded lymphatic network or lymphangiogenesis. APPROACH AND RESULTS: To this end, we used K14-VEGF-C (keratin-14 vascular endothelial growth factor-C) transgenic mice overexpressing the vascular endothelial growth factor C in skin and investigated the responses to inflammatory and fluid volume challenges...
September 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28935547/chronic-subdural-hematoma-a-perspective-on-subdural-membranes-and-dementia
#9
REVIEW
Ronald Sahyouni, Khodayar Goshtasbi, Amin Mahmoodi, Diem Kieu Tran, Jefferson W Chen
Chronic subdural hematoma (cSDH) is a common intracranial pathology, and a leading cause of reversible dementia. cSDH is projected to affect at least 60,000 new individuals in the United States annually by 2030.This can result from mild to moderate head trauma that leads to hemorrhaging in the dura-arachnoid interface. The short and long-term effects of cSDH and the subdural membrane on the pathogenesis of dementia and the newly discovered dural lymphatics is a topic of increasing importance. This manuscript aims to review the complex pathogenesis of the subdural membrane, and the link between head trauma, dementia, and dural lymphatics...
September 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28935473/use-of-sequential-pneumatic-compression-devices-to-facilitate-propagation-of-contrast-during-intranodal-lymphangiography
#10
Quinn C Meisinger, Sophia O'Brien, Maxim Itkin, Gregory J Nadolski
PURPOSE: To examine effects of lower extremity sequential compression devices (SCDs) on lymphatic transit during intranodal lymphangiography (IL) and thoracic duct interventions. MATERIALS AND METHODS: A retrospective review of 19 SCD-assisted IL (IL-SCD) procedures was performed. The control group comprised 18 consecutive IL-guided procedures performed in the immediately preceding time period. For IL-SCD procedures, SCDs were placed onto patients' calves before sterile preparation...
September 19, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28935258/rifampicin-lipid-polymer-hybrid-nanoparticles-lipomer-for-enhanced-peyer-s-patch-uptake
#11
Sagar S Bachhav, Vikas D Dighe, Darsheen Kotak, Padma V Devarajan
The oral uptake of intact nanocarriers through Peyer's patches is an important uptake pathway. We report Rifampicin Lipid-Polymer hybrid nanoparticles (RIF-LIPOMER) using glyceryl monostearate as lipid and the mucoadhesive polymer, Gantrez, with the objective of balancing hydrophobicity and mucoadhesion for enhanced Peyer's patch uptake. RIF-LIPOMER was optimized for size, hydrophobicity, and mucoadhesion using Box-Behnken. Design RIF-LIPOMER (RIF-LIPO-120) exhibited average particle size in the range 300-400nm with drug loading >12%...
September 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28934015/initial-clinical-experience-with-dual-agent-relaxation-contrast-for-isolated-lymphatic-channel-mapping
#12
Beth Ripley, Gregory J Wilson, Neeraj Lalwani, Noah Briller, Peter C Neligan, Jeffrey H Maki
Purpose To evaluate the clinical performance of dual-agent relaxation contrast (DARC) magnetic resonance (MR) lymphangiography compared with that of conventional MR lymphangiography in the creation of isolated lymphatic maps in patients with secondary lymphedema. Materials and Methods This retrospective study was approved by the institutional review board. The diagnostic quality of 42 DARC MR lymphangiographic studies was compared with that of 42 conventional MR lymphangiographic studies. Two independent readers rated venous contamination as absent, mild, or moderate to severe...
September 21, 2017: Radiology
https://www.readbyqxmd.com/read/28933995/identification-assessment-and-management-of-breast-oedema-after-treatment-for-cancer
#13
Marie Todd
Advances in breast cancer management, including breast-conserving surgery, have resulted in an increase in the incidence of breast oedema. However, this is addressed by professionals less often than arm lymphoedema. Breast oedema results in significant physical and psychological morbidity, makes finding a comfortably fitting bra very difficult, and can act as a reminder of the initial breast cancer diagnosis. Psychological difficulties can be compounded by clinicians' failure to acknowledge the impact. Assessing and managing breast oedema requires a sensitive, skilled approach to ensure all the relevant issues are identified and addressed in a comprehensive care plan; taking time to listen to patients and acknowledging the impact can be very therapeutic...
September 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28933960/the-mechanisms-of-il-17a-on-promoting-tumor-metastasis
#14
Ling-Ling Xu, Zhi-Jun Li, Xiu-Long Niu, Wei-Min Deng
In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, including hematogenous metastasis, lymphatic metastasis, local invasion and transcoelomic metastasis, to summarize the roles and underlying mechanisms of IL-17A on tumor metastasis.
September 21, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28932153/oral-squamous-cell-carcinoma-masquerading-as-gingival-overgrowth
#15
Roshni Ramesh, Arun Sadasivan
Gingival enlargements are frequently encountered in dental practice. There are different types of gingival enlargements and they vary according to the etiologic factors and pathologic processes that produce them. The exact diagnosis of the enlargement is important as some gingival enlargements can cause extensive morbidity or even mortality. Oral cancers especially squamous cell carcinomas present with variations in clinical presentation and the sites affected. A detailed medical history, clinical examination and radiographic evaluation will help identify the lesion...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28932085/novel-predictors-for-lymph-node-metastasis-in-submucosal-invasive-colorectal-carcinoma
#16
Kwangil Yim, Daeyoun David Won, In Kyu Lee, Seong-Taek Oh, Eun Sun Jung, Sung Hak Lee
AIM: To evaluate a novel grading system to predict lymph node metastasis (LNM) in patients with submucosal invasive colorectal carcinoma (SICRC). METHODS: We analyzed the associations between LNM and various clinicopathological features in 252 patients with SICRC who had undergone radical surgery at the Seoul Saint Mary's hospital between 2000 and 2015. RESULTS: LNM was observed in 31 patients (12.3%). The depth and width of the submucosal invasion, lymphatic invasion, tumor budding, and the presence of poorly differentiated clusters (PDCs) were significantly associated with the incidence of LNM...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28931417/sentinel-lymph-node-biopsy-in-periocular-merkel-cell-carcinoma-a-case-report
#17
Dan C Filitis, Gyorgy Paragh, Faramarz H Samie, Nathalie C Zeitouni
BACKGROUND: The National Comprehensive Cancer Network guidelines for Merkel cell carcinoma recommend performance of the sentinel lymph node biopsy in all patients with clinically negative nodal disease for staging and treatment. Nevertheless, sentinel lymph node biopsy in the periocular region is debated as tumors are typically smaller and lymphatic variability can make performance procedurally problematic. CASE PRESENTATION: We present a case of a Caucasian patient in their seventies who presented with a 1...
September 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28930779/inhibition-of-lymphatic-drainage-with-a-self-designed-surgical-approach-prolongs-the-vascularized-skin-allograft-survival-in-rats
#18
Jiaomiao Pei, Yang Li, Chen Chen, Xi Zhang, Shiping Wang, Yajuan Song, Bei Liu, Yingjun Su, Shuzhong Guo
Vascularized composite allotransplantation (VCA) is an emerging treatment for significant tissue defects. However, VCAs usually consist of multiple highly antigenic skin tissues. Previous studies have shown that the lymphatic system in skin plays important roles in the initiation of immune responses during acute rejection, by transporting T cells and antigen-presenting dendritic cells to regional lymph nodes. Therefore, we designed a new surgical treatment to inhibit lymphatic drainage of skin allografts and investigated whether this approach could promote the survival of allografts and suppress immunological events after transplantation...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28930285/interleukin-17a-negatively-regulates-lymphangiogenesis-in-t-helper-17-cell-mediated-inflammation
#19
H J Park, C M Yuk, K Shin, S-H Lee
During inflammation lymphatic vessels (LVs) are enlarged and their density is increased to facilitate the migration of activated immune cells and antigens. However, after antigen clearance, the expanded LVs shrink to maintain homeostasis. Here we show that interleukin (IL)-17A, secreted from T helper type 17 (TH17) cells, is a negative regulator of lymphangiogenesis during the resolution phase of TH17-mediated immune responses. Moreover, IL-17A suppresses the expression of major lymphatic markers in lymphatic endothelial cells and decreases in vitro LV formation...
September 20, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28929387/distinct-histopathological-characteristics-in-colorectal-submucosal-invasive-carcinoma-arising-in-sessile-serrated-adenoma-polyp-and-conventional-tubular-adenoma
#20
Takashi Murakami, Hiroyuki Mitomi, Takashi Yao, Tsuyoshi Saito, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Sumio Watanabe
The histopathological characteristics of colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp (SSA/P), a rare malignant tumour, have not yet been fully elucidated. To investigate the features of such, we retrospectively analysed 40 submucosal invasive carcinomas with SSA/P (CA-SSA/P) and compared them to 129 cases of submucosal invasive carcinoma with conventional tubular adenoma (CA-AD). We additionally performed hMLH1 immunostaining. CA-SSA/Ps were significantly smaller than CA-ADs (P < 0...
September 19, 2017: Virchows Archiv: An International Journal of Pathology
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