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extract against isolates of methicillin- resistant Staphylococcus aureus

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https://www.readbyqxmd.com/read/28216880/isolation-and-characterisation-of-a-proanthocyanidin-with-antioxidative-antibacterial-and-anti-cancer-properties-from-fern-blechnum-orientale
#1
How-Yee Lai, Yau-Yan Lim, Kah-Hwi Kim
BACKGROUND: Blechnum orientale Linn. (Blechnaceae), a fern, is traditionally used in the treatment of various ailments, such as skin diseases, stomach pain, urinary bladder complaints, and also as a female contraceptive. Previously, we reported a strong radical scavenging activity, antibacterial activity and cytotoxicity against HT29 colon cancer cells by aqueous extract of B. orientale. OBJECTIVE: In this study, we attempted to isolate and identify the active compound from the aqueous extract of B...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28209130/determination-of-antibacterial-activity-and-minimum-inhibitory-concentration-of-larval-extract-of-fly-via-resazurin-based-turbidometric-assay
#2
Chien Huey Teh, Wasi Ahmad Nazni, Ab Hamid Nurulhusna, Ahmad Norazah, Han Lim Lee
BACKGROUND: Antimicrobial resistance is currently a major global issue. As the rate of emergence of antimicrobial resistance has superseded the rate of discovery and introduction of new effective drugs, the medical arsenal now is experiencing shortage of effective drugs to combat diseases, particularly against diseases caused by the dreadful multidrug-resistant strains, such as the methicillin-resistant Staphylococcus aureus (MRSA). The ability of fly larvae to thrive in septic habitats has prompted us to determine the antibacterial activity and minimum inhibitory concentrations (MICs) of larval extract of flies, namely Lucilia cuprina, Sarcophaga peregrina and Musca domestica against 4 pathogenic bacteria [Staphylococcus aureus, methicillin-resistant S...
February 16, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28181080/madurastatin-b3-a-rare-aziridine-derivative-from-actinomycete-nocardiopsis-sp-ls150010-with-potent-anti-tuberculosis-activity
#3
Xinjun Zhang, Hongtao He, Rong Ma, Zengchun Ji, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang Song
Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare aziridine derivative, madurastatin B3 (1)...
February 8, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28044276/antimicrobial-potential-and-taxonomic-investigation-of-piezotolerant-streptomyces-sp-niot-ch-40-isolated-from-deep-sea-sediment
#4
Vishnu Priya Padmanaban, Pankaj Verma, Srividhyalakshmi Venkatabaskaran, Thirupathi Keppayan, Dharani Gopal, Ashok Kumar Sekar, Kirubagaran Ramalingam
Microbial-derived natural products from extreme niches such as deepsea are known to possess structural and functional novelty. With this background, the present study was designed to investigate the bioprospecting potential and systematics of a deep-sea derived piezotolerant bacterial strain NIOT-Ch-40, showing affiliation to the genus Streptomyces based on 16S RNA gene similarity. Preliminary screening for the presence of biosynthetic genes like polyketide synthase I, polyketide synthase II, non ribosomal peptide synthase, 3-amino-5-hydroxybenzoic acid synthase and spiroindimicin followed by antibacterial activity testing confirmed the presence of potent bioactivity...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28013553/in-vitro-anti-mrsa-activity-of-couroupita-guianensis-extract-and-its-component-tryptanthrin
#5
Danielle Cristina Machado Costa, Mariana Maria Barros de Azevedo, Davi Oliveira E Silva, Maria Teresa Villela Romanos, Thais Cristina Baeta Soares Souto-Padrón, Celuta Sales Alviano, Daniela Sales Alviano
Couroupita guianensis is known in Brazil as 'Abricó-de-Macaco' and it has some attributes such as: antihypertensive, analgesic and anti-inflammatory activities. This study evaluated the antimicrobial activity of ethanolic extract and fractions of C. guianensis flowers and isolation of bioactive component. These extracts and fractions were subjected to agar diffusion, MIC, TLC and bioautography to bacteria, filamentous fungi and yeasts. Among the fractions of EtOH extract, the DCM fraction was the most active, particularly against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 156 μg/mL...
December 26, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27912884/synergism-of-coumarins-from-the-chinese-drug-zanthoxylum-nitidum-with-antibacterial-agents-against-methicillin-resistant-staphylococcus-aureus-mrsa
#6
Guo-Ying Zuo, Chun-Juan Wang, Jun Han, Yu-Qing Li, Gen-Chun Wang
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious therapeutic challenge in current clinic and new drug development. Natural coumarins have diverse bioactivities and the potential of resistance modifying effects. PURPOSE: This study is to present in-depth evaluations of in vitro antimicrobial activities of four natural coumarins 5-geranyloxy-7-methoxycoumarin (Gm, 1), (5,7-dimethoxy-8-prenyloxycoumarin (artanin, Ar, 2)), isopimpinellin (Is, 3) and phellopterin (Ph, 4) from Zanthoxylum nitidum (Roxb...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27910164/hplc-uv-and-lc-ms-analyses-of-acylquinic-acids-in-geigeria-alata-dc-oliv-hiern-and-their-contribution-to-antioxidant-and-antimicrobial-capacity
#7
Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Maya M Zaharieva, Hristo Najdenski, Silviya Ruseva, Valentin Lozanov, Vessela Balabanova, Sakina Yagi, Georgi Momekov, Vanio Mitev
INTRODUCTION: Geigeria alata is a traditional plant used in Sudanese folk medicine for treatment of diabetes, cough, epilepsy and intestinal complaints. OBJECTIVE: To analyze phenolic acids in Geigeria alata roots and leaves and to evaluate their antioxidant and antimicrobial activities. METHODOLOGY: Phenolic acids in the aqueous-methanol extracts were identified by LC-MS. Major compounds were isolated using low-pressure liquid chromatography...
December 1, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27899152/the-anti-staphylococcus-aureus-activity-of-the-phenanthrene-fraction-from-fibrous-roots-of-bletilla-striata
#8
Jing-Jing Guo, Bin-Ling Dai, Ni-Pi Chen, Li-Xia Jin, Fu-Sheng Jiang, Zhi-Shan Ding, Chao-Dong Qian
BACKGROUND: Bletillae Rhizoma, the tuber of Bletilla striata, has been used in Chinese traditional medicine to treat infectious diseases. Chemical studies indicated that phenanthrene was one of the most important components of the herb, with a broad spectrum of antibiotic activity against Gram-positive bacteria. The objective of this study was to further characterize the antibacterial activity of the phenanthrene fraction from the fibrous root of the pseudobulb of B. striata. METHODS: The phenanthrene fraction (EF60) from the ethanol extract of fibrous roots of Bletilla striata pseudobulbs was isolated using polyamide column chromatography...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27808510/phenanthrenes-from-juncus-inflexus-with-antimicrobial-activity-against-methicillin-resistant-staphylococcus-aureus
#9
Barbara Tóth, Erika Liktor-Busa, Norbert Kúsz, Ádám Szappanos, Attila Mándi, Tibor Kurtán, Edit Urbán, Judit Hohmann, Fang-Rong Chang, Andrea Vasas
The present study has focused on an investigation of the antibacterial effects of Juncus inflexus and the isolation and identification of its active compounds. Eleven phenanthrenes were isolated from a methanolic extract of the roots. Four compounds (jinflexins A-D, 1-4) are new natural products, while seven phenanthrenes [juncuenins A (5), B (6), and D (8), juncusol (7), dehydrojuncuenins A (9) and B (11), and dehydrojuncusol (10)] were isolated for the first time from the plant. Jinflexin D (4) is a dimer with an unprecedented heptacyclic ring system...
November 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27784938/gc-ms-analysis-of-bio-active-molecules-derived-from-paracoccus-pantotrophus-fmr19-and-the-antimicrobial-activity-against-bacterial-pathogens-and-mdros
#10
I Faridha Begum, R Mohankumar, M Jeevan, K Ramani
The present investigation is focused on the study of chemical composition of a bioactive compound derived from a rumen isolate Paracoccus pantotrophus FMR19 using GC-MS and to find out the antibacterial activity of the extracted crude bioactive compounds against multidrug resistant organisms (MDROs) and other clinical pathogens. GC-MS analysis revealed that P. pantotrophus FMR19 produced eight major compounds that have been reported to exhibit antimicrobial property. The main components identified from hexane fraction are long chain alkanes, fatty alcohols, fatty acid methyl ester and aromatic hydrocarbons...
December 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27749645/nasal-carriage-of-methicillin-resistant-staphylococcus-aureus-and-the-effect-of-tea-extracts-on-isolates
#11
Amani F Abaza, Osama N Mohamed, Fathy K El-Fiky, Khaled A Ahmed
OBJECTIVES: This study aimed to determine the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage among patients, healthcare workers (HCWs), and community individuals, as well as to test the effect of tea extracts on detected S. aureus isolates. MATERIALS AND METHODS: This cross-sectional study that was followed by an experimental study included a total of 1021 nasal swab samples that were collected from 470 community cases, 191 HCWs, and 360 patients...
September 2016: Journal of the Egyptian Public Health Association
https://www.readbyqxmd.com/read/27668025/a-novel-topical-combination-ointment-with-antimicrobial-activity-against-methicillin-resistant-streptococcus-aureus-gram-negative-superbugs-yeasts-and-dermatophytic-fungi
#12
Kenneth S Thomson, Gina K Thomson, John Biehle, Andrew Deeb, Jamaal Crawford, R Herrera
BACKGROUND: The use of topical antimicrobial agents for management of minor skin infections is a clinical strategy that is commonly practiced in the community. Coupled with the use of topical antimicrobial agents is the emergence of antibiotic-resistant strains of pathogens leading to the need for alternative treatments. OBJECTIVE: A novel topical combination ointment consisting of salicylic acid, oak bark extract, benzoic acid, and polyethylene glycol (Bensal HP, Sonar products Inc...
2016: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/27644133/bioprospecting-from-cultivable-bacterial-communities-of-marine-sediment-and-invertebrates-from-the-underexplored-ubatuba-region-of-brazil
#13
Marcelo M P Tangerina, Hebelin Correa, Brad Haltli, Wagner Vilegas, Russell G Kerr
Shrimp fisheries along the Brazilian coast have significant environmental impact due to high by-catch rates (21 kg per kilogram of shrimp). Typically discarded, by-catch contains many invertebrates that may host a great variety of bacterial genera, some of which may produce bioactive natural products with biotechnological applications. Therefore, to utilize by-catch that is usually discarded we explored the biotechnological potential of culturable bacteria of two abundant by-catch invertebrate species, the snail Olivancillaria urceus and the sea star Luidia senegalensis...
January 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/27585260/anti-methicillin-resistant-staphylococcus-aureus-mrsa-activity-of-rubiaceae-fabaceae-and-poaceae-plants-a-search-for-new-sources-of-useful-alternative-antibacterials-against-mrsa-infections
#14
M Sharifi-Rad, M Iriti, M Sharifi-Rad, S Gibbons, J Sharifi-Rad
In this study, we evaluated the effects of the extracts of the leaves of species from the Rubiaceae (Galium aparine L. and Asperula arvensis L.), Fabaceae (Lathyrus aphaca L. and Vicia narbonensis L.) and Poaceae (Digitaria sanguinalis (L.) Scop. and Hordeum murinum L.) plant families on a wide and extensive panel of isolated methicillin-resistant Staphylococcus aureus strains (MRSA). The effects of the methanolic leaf extracts of Rubiaceae, Fabaceae and Poaceae plants on MRSA were evaluated by the disc diffusion assay and the broth dilution method...
August 29, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27478476/thin-layer-chromatography-bioautography-and-gas-chromatography-mass-spectrometry-of-antimicrobial-leaf-extracts-from-philippine-piper-betle-l-against-multidrug-resistant-bacteria
#15
Demetrio L Valle, Juliana Janet M Puzon, Esperanza C Cabrera, Windell L Rivera
This study isolated and identified the antimicrobial compounds of Philippine Piper betle L. leaf ethanol extracts by thin layer chromatography- (TLC-) bioautography and gas chromatography-mass spectrometry (GC-MS). Initially, TLC separation of the leaf ethanol extracts provided a maximum of eight compounds with R f values of 0.92, 0.86, 0.76, 0.53, 0.40, 0.25, 0.13, and 0.013, best visualized when inspected under UV 366 nm. Agar-overlay bioautography of the isolated compounds demonstrated two spots with R f values of 0...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27366351/investigation-the-efficiency-of-various-methods-of-volatile-oil-extraction-from-trichodesma-africanum-and-their-impact-on-the-antioxidant-and-antimicrobial-activities
#16
Nidal Amin Jaradat, Abdel Naser Zaid, Aladdin Abuzant, Ramzi Shawahna
BACKGROUND: Currently, there is an increasing interest in developing more efficient techniques for the extraction of phytochemicals. Microwaves and ultrasonic extraction methods are promising techniques that can be used for this purpose. OBJECTIVES: The purpose of this study was to investigate the impact of different extraction methods on yield, antioxidant and antimicrobial activities of volatile oil extracted from Trichodesma africanum. MATERIALS AND METHODS: Volatile oil was extracted using microwave, ultrasonic, microwave-ultrasonic, and conventional hydrodistillation methods...
June 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27330275/isolation-and-characterization-of-cyclo-tryptophanyl-prolyl-and-chloramphenicol-from-streptomyces-sp-suk-25-with-antimethicillin-resistant-staphylococcus-aureus-activity
#17
Muhanna M Alshaibani, Juriyati Jalil, Nik M Sidik, Ruangelie Edrada-Ebel, Noraziah M Zin
BACKGROUND: Zingiber spectabile, commonly known as Beehive Ginger, is used as an ethnobotanical plant in many countries as an appetizer or to treat stomachache, toothache, muscle sprain, and as a cure for swelling, sores and cuts. This is the first report of isolation of Streptomyces strain from the root of this plant. Strain Universiti Kebangsaan 25 (SUK 25) has a very high activity to produce secondary metabolites against methicillin-resistant Staphylococcus aureus (MRSA), which is associated with high morbidity and mortality rates due to acquired multidrug resistance genes and causes medication failure in some clinical cases worldwide...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27280932/labdane-diterpenoids-from-salvia-leriifolia-absolute-configuration-antimicrobial-and-cytotoxic-activities
#18
Mahdi Moridi Farimani, Akram Taleghani, Abbas Aliabadi, Atousa Aliahmadi, Mohammad Ali Esmaeili, Nazanin Namazi Sarvestani, Hamid Reza Khavasi, Martin Smieško, Matthias Hamburger, Samad Nejad Ebrahimi
Fractionation of an n-hexane extract of the aerial parts of Salvia leriifolia led to the isolation of two new (1, 2) and two known (3, 4) labdane diterpenoids, together with three other known compounds. The structures were established by a combination of 1D and 2D NMR, and HRESIMS. The structures of 1 and 3 were confirmed by single-crystal X-ray analysis. The absolute configuration of 1-4 was established by electronic circular dichroism spectroscopy. Compounds 1-4 were evaluated for their cytotoxic activities against MCF-7 human breast cancer cells...
September 2016: Planta Medica
https://www.readbyqxmd.com/read/27262066/chemical-constituents-cytotoxic-antifungal-and-antimicrobial-properties-of-centaurea-diluta-ait-subsp-algeriensis-coss-dur-maire
#19
Hanène Zater, Joëlle Huet, Véronique Fontaine, Samir Benayache, Caroline Stévigny, Pierre Duez, Fadila Benayache
OBJECTIVE: To investigate the chemical composition of a moderately polar extract (CHCl3 soluble part of the MeOH-H2O extract) obtained from the aerial parts (leaves and flowers) of Centaurea diluta Ait. subsp. algeriensis (Coss. & Dur.) Maire, a species endemic to Algeria and Morocco on which no reports are available to date. To evaluate in vitro the cytotoxic, antifungal and antimicrobial activities of this extract and the cytotoxic and antimicrobial activities of its isolated secondary metabolites...
June 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27190990/phytochemical-composition-and-antibacterial-activity-of-hydroalcoholic-extracts-of-pterospartum-tridentatum-and-mentha-pulegium-against-staphylococcus-aureus-isolates
#20
Alfredo Aires, Eduardo Marrinhas, Rosa Carvalho, Carla Dias, Maria José Saavedra
Pterospartum tridentatum and Mentha pulegium are largely used in Portuguese folk medicine to treat several human disorders and inflammatory processes but without any consistent evidence for those beneficial pointed properties. Thus, the aim of the current work is to evaluate its benefits and phytochemicals related to those beneficial properties. A distinct polyphenol profile between P. tridentatum and M. pulegium was found. Taxifolin, myricetin, ginestin, ginestein, and ginestein derivatives, biochanin A-glucoside, and biochanin A were identified in P...
2016: BioMed Research International
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