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extract against isolates of methicillin- resistant Staphylococcus aureus

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https://www.readbyqxmd.com/read/29024774/evaluation-of-antibacterial-potential-of-mangrove-sediment-derived-actinomycetes
#1
Suthinee Sangkanu, Vatcharin Rukachaisirikul, Chanwit Suriyachadkun, Souwalak Phongpaichit
Actinomycetes are well-known as the source of bioactive metabolites. In this work, 16 out of 118 (13.6%) isolates of mangrove sediment-derived actinomycetes showed potential antibacterial activity against at least one bacterial strain. Five extracts from isolates AMA11, AMA12 and AMA21 exhibited a broad spectrum antibacterial activity against Staphylococcus aureus ATCC25923, Staphylococcus epidermidis ATCC35984, methicillin-resistant S. aureus (MRSA) SK1, Acinetobacter baumannii NPRC004 and Escherichia coli ATCC25922...
October 9, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29019685/structures-and-antibacterial-properties-of-isorugosins-h-j-oligomeric-ellagitannins-from-liquidambar-formosana-with-characteristic-bridging-groups-between-sugar-moieties
#2
Yuuki Shimozu, Teruo Kuroda, Tomofusa Tsuchiya, Tsutomu Hatano
Three new ellagitannin oligomers, isorugosins H (1), I (2), and J (3), together with 11 known hydrolyzable tannins were isolated from an aqueous acetone extract of the fresh leaves of Liquidambar formosana. Their chemical structures were elucidated based on spectroscopic data and chemical conversion into known hydrolyzable tannins. The bridging mode of the valoneoyl groups between their sugar moieties has been identified only in this plant species. Additionally, the effects of the isorugosins isolated from this species on drug-resistant bacteria were evaluated and showed that isorugosin A (4) exhibited the most potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)...
October 11, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28953997/antimycobacterial-and-antimalarial-activities-of-endophytic-fungi-associated-with-the-ancient-and-narrowly-endemic-neotropical-plant-vellozia-gigantea-from-brazil
#3
Mariana C Ferreira, Charles L Cantrell, David E Wedge, Vívian N Gonçalves, Melissa R Jacob, Shabana Khan, Carlos A Rosa, Luiz H Rosa
BACKGROUND: Endophytic fungi, present mainly in the Ascomycota and Basidiomycota phyla, are associated with different plants and represent important producers of bioactive natural products. Brazil has a rich biodiversity of plant species, including those reported as being endemic. Among the endemic Brazilian plant species, Vellozia gigantea (Velloziaceae) is threatened by extinction and is a promising target to recover endophytic fungi. OBJECTIVE: The present study focused on bioprospecting of bioactive compounds of the endophytic fungi associated with V...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28942758/identification-and-heterologous-expression-of-the-kocurin-biosynthetic-gene-cluster
#4
Luis Linares-Otoya, Virginia Linares-Otoya, Lizbeth Armas-Mantilla, Cyntia Blanco-Olano, Max Crüsemann, Mayar L Ganoza-Yupanqui, Julio Campos-Florian, Gabriele M König, Till F Schäberle
The antibiotically bioactive thiopeptide compound kocurin was identified in extracts from a newly isolated Kocuria rosea strain. The axenic strain was retrieved from a soil sample of the intertidal area at the Paracas National Park, Peru. The genetic basis of this promising natural product with activity against methicillin-resistant Staphylococcus aureus (MRSA) strains was revealed by comparative genome analysis of this new isolate and other reported thiopeptide producer strains. The functionality of the predicted gene locus was experimentally proven by heterologous expression in Streptomyces coelicolor M1146...
September 25, 2017: Microbiology
https://www.readbyqxmd.com/read/28935203/hr-lc-ms-based-analysis-of-two-antibacterial-metabolites-from-a-marine-sponge-symbiont-streptomyces-pharmamarensis-icn40
#5
Francis-Joseph Rosemary Sharmila Joseph, Appadurai Muthamil Iniyan, Samuel Gnana Prakash Vincent
On the effort to screen antibiotics against Methicillin resistant Staphylococcus aureus (MRSA), an actinomycete strain which can produce bactericidal compound was isolated from a marine sponge of Kanyakumari Coast, India. Two anti-MRSA compounds (PVI401 and PVI402) were isolated from the fermentation plates of Streptomyces pharmamarensis ICN40. TLC bioautography analysis yielded two active spots with Rf value of 0.75 (PVI401) and 0.8 (PVI402) from the crude extract. Both the compounds were characterized by HR-LC-MS analysis...
October 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28932210/antibacterial-activity-of-endophytic-actinomycetes-isolated-from-the-medicinal-plant-vochysia-divergens-pantanal-brazil
#6
Francielly M W R Gos, Daiani C Savi, Khaled A Shaaban, Jon S Thorson, Rodrigo Aluizio, Yvelise M Possiede, Jürgen Rohr, Chirlei Glienke
Endophytic actinomycetes from medicinal plants produce a wide diversity of secondary metabolites (SM). However, to date, the knowledge about endophytes from Brazil remains scarce. Thus, we analyzed the antimicrobial potential of 10 actinomycetes isolated from the medicinal plant Vochysia divergens located in the Pantanal sul-mato-grossense, an unexplored wetland in Brazil. Strains were classified as belonging to the Aeromicrobium, Actinomadura, Microbacterium, Microbispora, Micrococcus, Sphaerisporangium, Streptomyces, and Williamsia genera, through morphological and 16S rRNA phylogenetic analyzes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28887200/purification-and-characterization-of-a-novel-anti-staphylococcal-peptide-asp-1-from-bacillus-sp-urid-12-1
#7
Ajay Ghosh Chalasani, Utpal Roy, Sushma Nema
A strong anti-methicillin resistant Staphylococcus aureus (MRSA) peptide (ASP-1) from the Bacillus subtilis URID 12.1 strain that is active against cefoxitin- and methicillin-resistant clinical isolates was purified to homogeneity by solvent extraction, silica gel-based adsorption chromatography and reversed phase High Performance Liquid Chromatography. The peptide sequence of ASP-1 as determined by MALDI-TOF/MS and ESI-FTICR MS was acetylated Phe-Thr-Ala-Val-Dhb-Phe-Ile/Leu. The peptide was further analyzed by alkaline hydrolysis, ESI-Q-TOF-MS and an ion mobility assay, which detected the presence of a lactone ring in the intact peptide and a cyclic nature, subsequently revealing the peptide sequence as acPhe-Thr-Val-Ala-Dhb-Phe-Ile/Leu...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28862674/biological-and-chemical-diversity-of-bacteria-associated-with-a-marine-flatworm
#8
Hui-Na Lin, Kai-Ling Wang, Ze-Hong Wu, Ren-Mao Tian, Guo-Zhu Liu, Ying Xu
The aim of this research is to explore the biological and chemical diversity of bacteria associated with a marine flatworm Paraplanocera sp., and to discover the bioactive metabolites from culturable strains. A total of 141 strains of bacteria including 45 strains of actinomycetes and 96 strains of other bacteria were isolated, identified and fermented on a small scale. Bioactive screening (antibacterial and cytotoxic activities) and chemical screening (ultra-performance liquid chromatography-mass spectrometry (UPLC-MS)) yielded several target bacterial strains...
September 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28855824/diversity-of-antagonistic-bacteria-isolated-from-medicinal-plant-peganum-harmala-l
#9
Fehmida Bibi
The antimicrobial activity of plant extract of Peganum harmala, a medicinal plant has been studied already. However, knowledge about bacterial diversity associated with different parts of host plant antagonistic to different human pathogenic bacteria is limited. In this study, bacteria were isolated from root, leaf and fruit of plant. Among 188 bacterial isolates isolated from different parts of the plant only 24 were found to be active against different pathogenic bacteria i.e. Escherichia coli, Methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecium, Enterococcus faecalis and Pseudomonas aeruginosa...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28800088/upregulation-and-identification-of-antibiotic-activity-of-a-marine-derived-streptomyces-sp-via-co-cultures-with-human-pathogens
#10
Anne A Sung, Samantha M Gromek, Marcy J Balunas
Marine natural product drug discovery has begun to play an important role in the treatment of disease, with several recently approved drugs. In addition, numerous microbial natural products have been discovered from members of the order Actinomycetales, particularly in the genus Streptomyces, due to their metabolic diversity for production of biologically active secondary metabolites. However, many secondary metabolites cannot be produced under laboratory conditions because growth conditions in flask culture differ from conditions in the natural environment...
August 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28710012/antibiofilm-activity-of-vetiveria-zizanioides-root-extract-against-methicillin-resistant-staphylococcus-aureus
#11
Arunachalam Kannappan, Shanmugaraj Gowrishankar, Ramanathan Srinivasan, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading human pathogen responsible for causing chronic clinical manifestation worldwide. In addition to antibiotic resistance genes viz. mecA and vanA, biofilm formation plays a prominent role in the pathogenicity of S. aureus by enhancing its resistance to existing antibiotics. Considering the role of folk medicinal plants in the betterment of human health from the waves of multidrug resistant bacterial infections, the present study was intended to explore the effect of Vetiveria zizanioides root on the biofilm formation of MRSA and its clinical counterparts...
July 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28659904/antimicrobial-potential-of-bacteria-associated-with-marine-sea-slugs-from-north-sulawesi-indonesia
#12
Nils Böhringer, Katja M Fisch, Dorothee Schillo, Robert Bara, Cora Hertzer, Fabian Grein, Jan-Hendrik Eisenbarth, Fontje Kaligis, Tanja Schneider, Heike Wägele, Gabriele M König, Till F Schäberle
Nudibranchia, marine soft-bodied organisms, developed, due to the absence of a protective shell, different strategies to protect themselves against putative predators and fouling organisms. One strategy is to use chemical weapons to distract predators, as well as pathogenic microorganisms. Hence, these gastropods take advantage of the incorporation of chemical molecules. Thereby the original source of these natural products varies; it might be the food source, de novo synthesis from the sea slug, or biosynthesis by associated bacteria...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28539745/effect-of-tamarindus-indica-l-and-manihot-esculenta-extracts-on-antibiotic-resistant-bacteria
#13
Zenon Machado Lima, Lenilson Santos da Trindade, Genelane Cruz Santana, Francine Ferreira Padilha, Marcelo da Costa Mendonça, Luiz Pereira da Costa, Jorge A López, Maria Lucila Hernández Macedo
BACKGROUND: The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria. OBJECTIVE: The aim of the present study was to evaluate the hydroethanolic leaf extracts of Tamarindus indica (tamarind) and Manihot esculenta (cassava) as antimicrobial potential against Pseudomonas aeruginosa clinical isolated and Methicillin-resistant Staphylococcus aureus...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28466299/streptomyces-sp-at37-isolated-from-a-saharan-soil-produces-a-furanone-derivative-active-against-multidrug-resistant-staphylococcus-aureus
#14
El Hadj Driche, Nasserdine Sabaou, Christian Bijani, Abdelghani Zitouni, Frédéric Pont, Florence Mathieu, Boubekeur Badji
A novel actinobacterium strain, named AT37, showed a strong activity against some multidrug-resistant Staphylococcus aureus, including methicillin-resistant S. aureus MRSA ATCC 43300, other clinical isolates of MRSA and vancomycin resistant S. aureus VRSA S1. The strain AT37 was isolated from a Saharan soil by a dilution agar plating method using chitin-vitamin agar medium supplemented with rifampicin. The morphological and chemical studies indicated that this strain belonged to the genus Streptomyces. Its 16S rRNA gene sequence was determined and a database search indicated that it was closely associated with the type strain of Streptomyces novaecaesareae NBRC 13368(T) with 99...
June 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28375113/antibacterial-activity-of-crude-methanolic-extract-and-various-fractions-of-vitex-agnus-castus-and-myrsine-africana-against-clinical-isolates-of-methicillin-resistant-staphylococcus-aureus
#15
Bashir Ahmad, Nabia Hafeez, Gulshan Ara, Sadiq Azam, Shumaila Bashir, Ibrar Khan
Staphylococcus aureus is a nosocomial pathogen that resides in the soft tissues causing many diseases. The current study was conducted to determine the prevalence of Methicillin Resistant S. aureus (MRSA) in ear discharge and pus of patients and antibacterial activity of crude methanolic extract (Cr. MeOH Ext.) and various fractions of M. Africana and V. agnus castus against clinical isolates of MRSA. A total of 40 samples were collected from ear, nose and throat (ENT) outpatient department and wards of Khyber Teaching Hospital (KTH), Peshawar...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28216880/isolation-and-characterisation-of-a-proanthocyanidin-with-antioxidative-antibacterial-and-anti-cancer-properties-from-fern-blechnum-orientale
#16
How-Yee Lai, Yau-Yan Lim, Kah-Hwi Kim
BACKGROUND: Blechnum orientale Linn. (Blechnaceae), a fern, is traditionally used in the treatment of various ailments, such as skin diseases, stomach pain, urinary bladder complaints, and also as a female contraceptive. Previously, we reported a strong radical scavenging activity, antibacterial activity and cytotoxicity against HT29 colon cancer cells by aqueous extract of B. orientale. OBJECTIVE: In this study, we attempted to isolate and identify the active compound from the aqueous extract of B...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28209130/determination-of-antibacterial-activity-and-minimum-inhibitory-concentration-of-larval-extract-of-fly-via-resazurin-based-turbidometric-assay
#17
Chien Huey Teh, Wasi Ahmad Nazni, Ab Hamid Nurulhusna, Ahmad Norazah, Han Lim Lee
BACKGROUND: Antimicrobial resistance is currently a major global issue. As the rate of emergence of antimicrobial resistance has superseded the rate of discovery and introduction of new effective drugs, the medical arsenal now is experiencing shortage of effective drugs to combat diseases, particularly against diseases caused by the dreadful multidrug-resistant strains, such as the methicillin-resistant Staphylococcus aureus (MRSA). The ability of fly larvae to thrive in septic habitats has prompted us to determine the antibacterial activity and minimum inhibitory concentrations (MICs) of larval extract of flies, namely Lucilia cuprina, Sarcophaga peregrina and Musca domestica against 4 pathogenic bacteria [Staphylococcus aureus, methicillin-resistant S...
February 16, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28181080/madurastatin-b3-a-rare-aziridine-derivative-from-actinomycete-nocardiopsis-sp-ls150010-with-potent-anti-tuberculosis-activity
#18
Xinjun Zhang, Hongtao He, Rong Ma, Zengchun Ji, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang Song
Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare aziridine derivative, madurastatin B3 (1)...
May 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28044276/antimicrobial-potential-and-taxonomic-investigation-of-piezotolerant-streptomyces-sp-niot-ch-40-isolated-from-deep-sea-sediment
#19
Vishnu Priya Padmanaban, Pankaj Verma, Srividhyalakshmi Venkatabaskaran, Thirupathi Keppayan, Dharani Gopal, Ashok Kumar Sekar, Kirubagaran Ramalingam
Microbial-derived natural products from extreme niches such as deepsea are known to possess structural and functional novelty. With this background, the present study was designed to investigate the bioprospecting potential and systematics of a deep-sea derived piezotolerant bacterial strain NIOT-Ch-40, showing affiliation to the genus Streptomyces based on 16S RNA gene similarity. Preliminary screening for the presence of biosynthetic genes like polyketide synthase I, polyketide synthase II, non ribosomal peptide synthase, 3-amino-5-hydroxybenzoic acid synthase and spiroindimicin followed by antibacterial activity testing confirmed the presence of potent bioactivity...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28013553/in-vitro-anti-mrsa-activity-of-couroupita-guianensis-extract-and-its-component-tryptanthrin
#20
Danielle Cristina Machado Costa, Mariana Maria Barros de Azevedo, Davi Oliveira E Silva, Maria Teresa Villela Romanos, Thais Cristina Baeta Soares Souto-Padrón, Celuta Sales Alviano, Daniela Sales Alviano
Couroupita guianensis is known in Brazil as 'Abricó-de-Macaco' and it has some attributes such as: antihypertensive, analgesic and anti-inflammatory activities. This study evaluated the antimicrobial activity of ethanolic extract and fractions of C. guianensis flowers and isolation of bioactive component. These extracts and fractions were subjected to agar diffusion, MIC, TLC and bioautography to bacteria, filamentous fungi and yeasts. Among the fractions of EtOH extract, the DCM fraction was the most active, particularly against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 156 μg/mL...
September 2017: Natural Product Research
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