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https://www.readbyqxmd.com/read/28934247/the-extent-of-intrauterine-growth-restriction-determines-the-severity-of-cerebral-injury-and-neurobehavioural-deficits-in-rodents
#1
Crystal A Ruff, Stuart D Faulkner, Prakasham Rumajogee, Stephanie Beldick, Warren Foltz, Jennifer Corrigan, Alfred Basilious, Shangjun Jiang, Shanojan Thiyagalingam, Jerome Y Yager, Michael G Fehlings
BACKGROUND: Cerebral Palsy (CP) is the most common physical pediatric neurodevelopmental disorder and spastic diplegic injury is its most frequent subtype. CP results in substantial neuromotor and cognitive impairments that have significant socioeconomic impact. Despite this, its underlying pathophysiological mechanisms and etiology remain incompletely understood. Furthermore, there is a need for clinically relevant injury models, which a) reflect the heterogeneity of the condition and b) can be used to evaluate new translational therapies...
2017: PloS One
https://www.readbyqxmd.com/read/28932985/lung-cancer-screening-with-mri-results-of-the-first-screening-round
#2
Michael Meier-Schroers, Rami Homsi, Dirk Skowasch, Jens Buermann, Matthias Zipfel, Hans Heinz Schild, Daniel Thomas
PURPOSE: To evaluate the suitability of MRI for lung cancer screening in a high-risk population. MATERIALS AND METHODS: A 5-year lung cancer screening program comparing MRI and low-dose CT (LDCT) in a high-risk population was initiated. 224 subjects were examined with MRI and LDCT. Acquired MRI sequences were T2w MultiVane XD, balanced steady-state-free precession, 3D T1w GRE, and DWI with a maximum in-room-time of 20 min. Categorization and management of nodules were based on Lung-RADS...
September 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28932698/quantitative-magnetic-resonance-mr-neurography-for-evaluation-of-peripheral-nerves-and-plexus-injuries
#3
REVIEW
Teodoro Martín Noguerol, Rafael Barousse, Mariano Socolovsky, Antonio Luna
Traumatic conditions of peripheral nerves and plexus have been classically evaluated by morphological imaging techniques and electrophysiological tests. New magnetic resonance imaging (MRI) studies based on 3D fat-suppressed techniques are providing high accuracy for peripheral nerve injury evaluation from a qualitative point of view. However, these techniques do not provide quantitative information. Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) are functional MRI techniques that are able to evaluate and quantify the movement of water molecules within different biological structures...
August 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28932564/assessment-of-pulmonary-microstructural-changes-by-hyperpolarized-129-xe-diffusion-weighted-imaging-in-an-elastase-instilled-rat-model-of-emphysema
#4
Ke Wang, Ting Pan, Hao Yang, Weiwei Ruan, Jianping Zhong, Guangyao Wu, Xin Zhou
BACKGROUND: The purpose of this study was to explore the feasibility of hyperpolarized (129)Xe diffusion-weighted imaging (DWI) for the evaluation of pulmonary microstructural changes in the presence of pancreatic porcine elastase (PPE)-induced pulmonary emphysema rat model. METHODS: Sixteen male Sprague-Dawley (SD) rats were randomly divided into two groups, the emphysema model group and control group. Experimental emphysematous models were made by instilling elastase into rat lungs of model group, the control group were instilled with isodose saline...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932362/clinical-radiological-pathological-correlation-of-cavernous-sinus-hemangioma-incremental-value-of-diffusion-weighted-imaging
#5
Abhishek Mahajan, Vedula Rajni Kanth Rao, Gudipati Anantaram, Ashwin M Polnaya, Sandeep Desai, Paresh Desai, Rammohan Vadapalli, Manas Panigrahi
AIM: To elucidate the clinical, magnetic resonance imaging (MRI), pathological features of these lesions and asses the incremental value of diffusion-weighted imaging (DWI) in diagnosing them. METHODS: Fifteen consecutive patients (11 females and 4 males; mean age 40.93 years; age range 13-63 years) with cavernous sinus hemangiomas (CSH) who underwent examination between November 2008 and May 2016 were included for the analysis. MRI, clinical and surgical findings of each patient was retrospectively reviewed...
August 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28930805/the-value-of-diffusion-weighted-imaging-in-combination-with-conventional-magnetic-resonance-imaging-for-improving-tumor-detection-for-early-cervical-carcinoma-treated-with-fertility-sparing-surgery
#6
Xiulei Li, Ling Wang, Yong Li, Peiji Song
OBJECTIVE: This study aimed to investigate the value of diffusion-weighted imaging (DWI) in combination with conventional magnetic resonance imaging (MRI) for improving tumor detection in young patients treated with fertility-sparing surgery because of early cervical carcinoma. METHODS: Fifty-four patients with stage Ia or Ib1 cervical carcinoma were enrolled into this study. Magnetic resonance examinations were performed for these patients using conventional MRI (including T1-weighted imaging, T2-weighted imaging, and dynamic contrast-enhanced MRI) and DWI...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28929111/monitoring-leiomyoma-response-to-uterine-artery-embolization-using-diffusion-and-perfusion-indices-from-diffusion-weighted-imaging
#7
Mengqiu Cao, Lijun Qian, Xuebin Zhang, Xinjun Suo, Qing Lu, Huilin Zhao, Jialin Liu, Jianxun Qu, Yan Zhou, Jianrong Xu, Shiteng Suo
PURPOSE: To investigate the potential of diffusion and perfusion indices (ADC and perfusion fraction f) from DWI at 3.0 T in monitoring treatment response to uterine artery embolization (UAE) at 6-month follow-up. METHODS: Twelve female patients with uterine fibroids who underwent 3.0-T pelvic DWI before and 6 months after UAE were included. ADC and perfusion fraction f were calculated from DWI. The Wilcoxon signed-rank test and Spearman rank correlation test were used for statistics...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28921633/spontaneous-mechanical-and-electrical-activities-of-human-calf-musculature-at-rest-assessed-by-repetitive-single-shot-diffusion-weighted-mri-and-simultaneous-surface-electromyography
#8
Martin Schwartz, Günter Steidle, Petros Martirosian, Ander Ramos-Murguialday, Hubert Preißl, Alto Stemmer, Bin Yang, Fritz Schick
PURPOSE: Assessment of temporal and spatial relations between spontaneous mechanical activities in musculature (SMAM) at rest as revealed by diffusion-weighted imaging (DWI) and electrical muscular activities in surface EMG (sEMG). Potential influences of static and radiofrequency magnetic fields on muscular activity on sEMG measurements at rest were examined systematically. METHODS: Series of diffusion-weighted stimulated echo planar imaging were recorded with concurrent sEMG measurements...
September 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28921384/can-diffusion-weighted-imaging-distinguish-between-benign-and-malignant-pediatric-liver-tumors
#9
Pablo Caro-Domínguez, Abha A Gupta, Govind B Chavhan
BACKGROUND: There are limited data on utility of diffusion-weighted imaging (DWI) in the evaluation of pediatric liver lesions. OBJECTIVE: To determine whether qualitative and quantitative DWI can be used to differentiate benign and malignant pediatric liver lesions. MATERIALS AND METHODS: We retrospectively reviewed MRIs in children with focal liver lesions to qualitatively evaluate lesions noting diffusion restriction, T2 shine-through, increased diffusion, hypointensity on DWI and apparent diffusion coefficient (ADC) maps, and intermediate signal on both, and to measure ADC values...
September 18, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28920444/mri-findings-and-demographics-of-elastofibroma-dorsi-assessment-of-diffusion-weighted-imaging-and-contrast-enhancement-patterns
#10
Maho Tsubakimoto, Tsuneo Yamashiro, Nanae Tsuchiya, Masahiro Okada, Hiroki Maehara, Kaoru Kitsukawa, Sadayuki Murayama
Background Elastofibroma dorsi is a rare pseudotumoral lesion. Thus, there is no report of magnetic resonance imaging (MRI) findings that investigates multiple patients particularly with respect to diffusion-weighted imaging (DWI) findings and contrast enhancement patterns. Purpose To describe the imaging findings of elastofibroma on MRI, particularly DWI findings and contrast enhancement patterns, and to further investigate patient demographics. Material and Methods Forty-four patients with elastofibroma that underwent MRI were enrolled in this retrospective study...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28919227/asymptomatic-ischemic-risks-in-microsurgical-clipping-for-unruptured-intracranial-aneurysms-in-anterior-circulation
#11
Katsuhiro Shinagawa, Toshinori Matsushige, Takahito Okazaki, Daizo Ishii, Nobuhiko Ichinose, Shigeyuki Sakamoto, Kaoru Kurisu
BACKGROUND: The ischemic risk in prophylactic treatments of unruptured intracranial aneurysms (UIAs) is a serious health concern. OBJECTIVE: The aim of this study was to elucidate the incidence and characteristics of ischemic events in microsurgical clipping (MC) of anterior circulation UIAs. METHODS: Ischemic events were prospectively evaluated before and after surgery between April 2011 and March 2017. The location, volume, minimum value of apparent diffusion coefficient (ADCMIN) in high-intensity spots (HIS) on 3T MR Diffusion-weighted imaging (DWI), and radiographic outcomes were analyzed...
September 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28914609/effect-of-multiple-perfusion-components-on-pseudo-diffusion-coefficient-in-intravoxel-incoherent-motion-imaging
#12
Zi-Xiang Kuai, Wan-Yu Liu, Yue-Min Zhu
The aim of this work was to investigate the effect of multiple perfusion components on the pseudo-diffusion coefficient D* in the bi-exponential intravoxel incoherent motion (IVIM) model. Simulations were first performed to examine how the presence of multiple perfusion components influences D*. The real data of livers (n=31), spleens (n=31) and kidneys (n=31) of 31 volunteers was then acquired using DWI for in vivo study and the number of perfusion components in these tissues was determined together with their perfusion fraction and D*, using an adaptive multi-exponential IVIM model...
September 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28906581/is-there-a-benefit-of-mechanical-thrombectomy-in-patients-with-large-stroke-dwi-aspects%C3%A2-5
#13
Pierre-François Manceau, Sébastien Soize, Matthias Gawlitza, Guillaume Fabre, Serge Bakchine, Carole Durot, Isabelle Serre, Georgios-Emmanouil Metaxas, Laurent Pierot
BACKGROUND: Whether to withhold mechanical thrombectomy when the diffusion-weighted imaging (DWI) lesion exceeds a given volume is undetermined. We aimed to identify markers that will help to select patients with large DWI lesions (DWI-Alberta Stroke Program Early CT Score, DWI-ASPECTS≤5) that may benefit from thrombectomy. METHODS: From May 2010 to November 2016, we studied 82 acute ischemic stroke patients with DWI-ASPECTS≤5 (43 men, 64.6±14.4 years, NIHSS 18...
September 14, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28906339/multiparametric-magnetic-resonance-imaging-of-prostate-cancer-bone-disease-correlation-with-bone-biopsy-histological-and-molecular-features
#14
Raquel Perez-Lopez, Daniel Nava Rodrigues, Ines Figueiredo, Joaquin Mateo, David J Collins, Dow-Mu Koh, Johann S de Bono, Nina Tunariu
OBJECTIVES: The aim of this study was to correlate magnetic resonance imaging (MRI) of castration-resistant prostate cancer (CRPC) bone metastases with histological and molecular features of bone metastases. MATERIALS AND METHODS: Forty-three bone marrow biopsies from 33 metastatic CRPC (mCRPC) patients with multiparametric MRI and documented bone metastases were evaluated. A second cohort included 10 CRPC patients with no bone metastases. Associations of apparent diffusion coefficient (ADC), normalized b900 diffusion-weighted imaging (nDWI) signal, and signal-weighted fat fraction (swFF) with bone marrow biopsy histological parameters were evaluated using Mann-Whitney U test and Spearman correlations...
September 12, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28906310/endometrial-stromal-sarcoma-of-the-uterus-magnetic-resonance-imaging-findings-including-apparent-diffusion-coefficient-value-and-its-correlation-with-ki-67-expression
#15
Hai Ming Li, Jia Liu, Jin Wei Qiang, Wei Yong Gu, Guo Fu Zhang, Feng Hua Ma
OBJECTIVE: This study aimed to investigate the conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) features of endometrial stromal sarcoma (ESS) including a preliminary investigation of the correlation between the apparent diffusion coefficient (ADC) value and Ki-67 expression. METHODS: The clinical and MRI data of 15 patients with ESS confirmed by surgery and pathology were analyzed retrospectively. The conventional MR morphological features, signal intensity on DWI, ADC value (n = 14), and clinicopathological marker Ki-67 (n = 13) were evaluated...
September 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28905134/postmortem-mr-diffusion-weighted-imaging-of-the-liver-time-behavior-of-the-hepatic-apparent-diffusion-coefficient-in-the-early-death-interval
#16
Sarah Keller, Tony M Schmidt, Anne Catherine Kim, Roland Fischer, Axel Heinemann, Gerhard Adam, Jin Yamamura
OBJECTIVE: The objective of this study is to assess postmortem changes of the hepatic apparent diffusion coefficient (ADC) at multiple time points in the time interval of 16 hours postmortem in comparison to in vivo controls and to literature data. MATERIAL AND METHODS: Hepatic diffusion-weighted imaging (DWI) was repeatedly performed at 1.5 Tesla (b values 50, 400, and 800 s/mm(2)) in 2-hourly steps within 16 hours postmortem in 19 cases (male to female 13:6, mean age 68...
September 14, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28905109/white-matter-microstructure-of-attentional-networks-predicts-attention-and-consciousness-functional-interactions
#17
Ana B Chica, Michel Thiebaut de Schotten, Paolo Bartolomeo, Pedro M Paz-Alonso
Attention is considered as one of the pre-requisites of conscious perception. Phasic alerting and exogenous orienting improve conscious perception of near-threshold information through segregated brain networks. Using a multimodal neuroimaging approach, combining data from functional MRI (fMRI) and diffusion-weighted imaging (DWI), we investigated the influence of white matter properties of the ventral branch of superior longitudinal fasciculus (SLF III) in functional interactions between attentional systems and conscious perception...
September 13, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28903414/micro-hccs-in-rats-with-liver-cirrhosis-paradoxical-targeting-effects-with-vascular-disrupting-agent-ca4p
#18
Yewei Liu, Ting Yin, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jianjun Liu, Shaoli Song, Jie Yu, Vincent Vandecaveye, Johan Swinnen, Guy Bormans, Uwe Himmelreich, Raymond Oyen, Jian Zhang, Gang Huang, Yicheng Ni
We sought to investigate anticancer efficacy of a vascular disrupting agent (VDA) combretastatin A-4 phosphate (CA4P) in relation to tumor size among hepatocellular carcinomas (HCCs) in rats using magnetic resonance imaging (MRI) and postmortem techniques. Nineteen rats with 43 chemically-induced HCCs of 2.8-20.9 mm in size on liver cirrhosis received CA4P intravenously at 10 mg/kg. Tumor-diameter was measured by T2-weighted imaging (T2WI) to define microcancers (< 5 mm) versus larger HCCs. Vascular responses and tissue necrosis were detected by diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (CE-T1WI) and dynamic contrast enhanced (DCE-) MRI, which were validated by microangiography and histopathology...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900832/spatial-discrimination-of-glioblastoma-and-treatment-effect-with-histologically-validated-perfusion-and-diffusion-magnetic-resonance-imaging-metrics
#19
Melissa A Prah, Mona M Al-Gizawiy, Wade M Mueller, Elizabeth J Cochran, Raymond G Hoffmann, Jennifer M Connelly, Kathleen M Schmainda
The goal of this study is to spatially discriminate tumor from treatment effect (TE), within the contrast-enhancing lesion, for brain tumor patients at all stages of treatment. To this end, the diagnostic accuracy of MRI-derived diffusion and perfusion parameters to distinguish pure TE from pure glioblastoma (GBM) was determined utilizing spatially-correlated biopsy samples. From July 2010 through June 2015, brain tumor patients who underwent pre-operative DWI and DSC-MRI and stereotactic image-guided biopsy were considered for inclusion in this IRB-approved study...
September 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28899807/tn2008-driven-carbapenem-resistance-in-acinetobacter-baumannii-isolates-from-a-period-of-increased-incidence-of-infections-in-a-southwest-virginia-hospital
#20
Jayasimha Rao, Dwi Susanti, Johnathon C Childress, Michael C Mitkos, Joshua K Brima, Anthony W Baffoe-Bonnie, Samuel N Pearce, Dale Grgurich, Maria Jose Fernandez-Cotarelo, Thomas M Kerkering, Biswarup Mukhopadhyay
OBJECTIVES: The objectives of this study were to determine the genetic basis for carbapenem resistance in multidrug-resistant Acinetobacter baumannii strains isolated from patients affected by a sudden increase in the incidence of infections by such organisms in a tertiary care hospital in Virginia, USA, in 2009-2010 and to examine whether such strains are commonly encountered in the hospital setting. METHODS: The whole genomes of one outbreak strain, one carbapenem-resistant strain and one carbapenem-sensitive strain from sporadic infections in 2010-2012 were sequenced and analyzed...
September 9, 2017: Journal of Global Antimicrobial Resistance
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