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https://www.readbyqxmd.com/read/29666296/phase-ii-study-to-evaluate-the-efficacy-and-safety-of-rilotumumab-and-bevacizumab-in-subjects-with-recurrent-malignant-glioma
#1
Mary Lou Affronti, Jennifer Gamboa Jackman, Frances McSherry, James E Herndon, Elwood C Massey, Eric Lipp, Annick Desjardins, Henry S Friedman, Gordana Vlahovic, James Vredenburgh, Katherine B Peters
LESSONS LEARNED: Due to evolving imaging criteria in brain tumors and variation in magnetic resonance imaging evaluation, it is not ideal to use response rate as a primary objective. Future studies involving antiangiogenic agents should use overall survival.Disease-expected toxicities should be considered when defining the clinical significance of an adverse event. For example, vascular thromboembolic events are common in brain tumor patients and should not be attributed to the study drug in the safety analysis...
April 17, 2018: Oncologist
https://www.readbyqxmd.com/read/29662558/radiomics-as-a-quantitative-imaging-biomarker-practical-considerations-and-the-current-standpoint-in-neuro-oncologic-studies
#2
REVIEW
Ji Eun Park, Ho Sung Kim
Radiomics utilizes high-dimensional imaging data to discover the association with diagnostic, prognostic, predictive endpoint or radiogenomics. It is an emerging field of study that potentially depicts the intratumoral heterogeneity from quantitative and classified high-throughput data. The radiomics approach has an analytic pipeline where the imaging features are extracted, processed and analyzed. At this point, special data handling is essential because it faces issues of a high-dimensional biomarker compared to a single biomarker approach...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29656021/next-generation-neuro-oncology
#3
REVIEW
Michael Weller
Neuro-oncology has evolved as a growing, but still small, highly specialised and multidisciplinary field at the interface of several diagnostic and therapeutic disciplines. The major challenge in the field of primary tumours is to translate the almost unique progress in deciphering the highly complex molecular genetic nature of many primary brain tumours, notably glioblastoma, into advances that allow for clinical benefit for affected patients. Furthermore, metastases to the central nervous system are an increasingly prevalent complication in many systemic cancers...
April 12, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29651966/specific-cytostatic-and-cytotoxic-effect-of-dihydrochelerythrine-in-glioblastoma-cells-role-of-nf-kb-b-catenin-and-stat3-il-6-pathways
#4
Tereza Cristina Costa Silva, Noelio de Jesus Menezes-Filho, Giselle Pinto de Faria Lopes, Diego Madureira de Oliveira, Ezequiel Pereira, Bruno Penas Seara Pitanga, Eudes S Velozo, Songeli Menezes Freire, Jorge Clarencio de Souza Andrade, Helena Lobo Borges, Stevens Kastrup Rehen, Vivaldo Moura-Neto, Silvia Lima Costa
A glioblastoma is a primary CNS tumor that is more aggressive and lethal than other brain tumors. Its location, rapid proliferation, invasive growth, angiogenesis and immunosuppression are the main factors that limit its treatment, making it a major challenge to neuro-oncology. OBJECTIVE: This study investigated the in vitro effects of the alkaloid dihydrochelerythrine (DHC), which is extracted from Zanthoxylum stelligerum, on the viability, proliferation, cell death and b-catenin, NFkB, STAT3/pSTAT3 and interleukins roles...
April 12, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29644808/prognostic-evaluation-of-neurological-assessment-of-the-neuro-oncology-scale-in-glioblastoma-patients
#5
Jiwook Lee, Sung Hyun Park, Young Zoon Kim
BACKGROUND: The aims of this study were to investigate the role of the Neurological Assessment of Neuro-Oncology (NANO) scale in predicting the prognosis of patients with glioblastoma, and compare these results to predicted data of the Karnofsky Performance Scale (KPS), and Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) performance status. Additionally, we examined other prognostic factors in glioblastoma patients. METHODS: The medical records of 76 patients with a new diagnosis of histologically ascertained glioblastoma in the period from January 2002 to December 2015 at the authors' institution were retrospectively reviewed...
April 2, 2018: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29642503/migration-invasion-of-malignant-gliomas-and-implications-for-therapeutic-treatment
#6
REVIEW
Ching-Ann Liu, Chia-Yu Chang, Kuo-Wei Hsueh, Hong-Lin Su, Tzyy-Wen Chiou, Shinn-Zong Lin, Horng-Jyh Harn
Malignant tumors of the central nervous system (CNS) are among cancers with the poorest prognosis, indicated by their association with tumors of high-level morbidity and mortality. Gliomas, the most common primary CNS tumors that arise from neuroglial stem or progenitor cells, have estimated annual incidence of 6.6 per 100,000 individuals in the USA, and 3.5 per 100,000 individuals in Taiwan. Tumor invasion and metastasis are the major contributors to the deaths in cancer patients. Therapeutic goals including cancer stem cells (CSC), phenotypic shifts, EZH2/AXL/TGF-β axis activation, miRNAs and exosomes are relevant to GBM metastasis to develop novel targeted therapeutics for GBM and other brain cancers...
April 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629823/durable-response-to-bevacizumab-in-adults-with-recurrent-pilocytic-astrocytoma
#7
Andrea Wasilewski, Nimish Mohile
BACKGROUND: Adult pilocytic astrocytomas are rare and highly vascular tumors. AIM: We hypothesized that they may be uniquely responsive to bevacizumab (BEV). PATIENTS: We present four adult patients with pathologically diagnosed WHO grade I pilocytic astrocytoma who had robust and durable responses to BEV at time of recurrence. Three patients developed radiographic changes on MRI, consistent with progressive disease based on response assessment in neuro-oncology criteria...
April 9, 2018: CNS Oncology
https://www.readbyqxmd.com/read/29627863/the-codesign-of-an-interdisciplinary-team-based-intervention-regarding-initiating-palliative-care-in-pediatric-oncology
#8
Douglas L Hill, Jennifer K Walter, Jessica A Casas, Concetta DiDomenico, Julia E Szymczak, Chris Feudtner
PURPOSE: Children with advanced cancer are often not referred to palliative or hospice care before they die or are only referred close to the child's death. The goals of the current project were to learn about pediatric oncology team members' perspectives on palliative care, to collaborate with team members to modify and tailor three separate interdisciplinary team-based interventions regarding initiating palliative care, and to assess the feasibility of this collaborative approach. METHODS: We used a modified version of experience-based codesign (EBCD) involving members of the pediatric palliative care team and three interdisciplinary pediatric oncology teams (Bone Marrow Transplant, Neuro-Oncology, and Solid Tumor) to review and tailor materials for three team-based interventions...
April 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29621181/dabrafenib-treatment-in-a-patient-with-an-epithelioid-glioblastoma-and-braf-v600e-mutation
#9
Garry Ceccon, Jan-Michael Werner, Veronika Dunkl, Caroline Tscherpel, Gabriele Stoffels, Anna Brunn, Martina Deckert, Gereon R Fink, Norbert Galldiks
Novel therapeutic targets in malignant glioma patients are urgently needed. Point mutations of the v-Raf murine sarcoma viral oncogene homolog B ( BRAF ) gene occur predominantly in melanoma patients, but may also occur in gliomas. Thus, this is a target of great interest for this group of patients. In a nine-year-old male patient, an anaplastic astrocytoma in the left temporoparietal region was diagnosed histologically. After first- and second-line treatment, a malignant progression to a secondary glioblastoma was observed ten years after the initial diagnosis...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29618103/the-neurologic-assessment-in-neuro-oncology-nano-scale-as-an-assessment-tool-for-survival-in-patients-with-primary-glioblastoma
#10
Timothy H Ung, Douglas E Ney, Denise Damek, Chad G Rusthoven, A Samy Youssef, Kevin O Lillehei, D Ryan Ormond
BACKGROUND: The Neurologic Assessment in Neuro-Oncology (NANO) scale is a standardized objective metric designed to measure neurological function in neuro-oncology. Current neuroradiological evaluation guidelines fail to use specific clinical criteria for progression. OBJECTIVE: To determine if the NANO scale was a reliable assessment tool in glioblastoma (GBM) patients and whether it correlated to survival. METHODS: Our group performed a retrospective review of all patients with newly diagnosed GBM from January 1, 2010, through December 31, 2012, at our institution...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29616301/reconstructing-the-molecular-life-history-of-gliomas
#11
REVIEW
Floris P Barthel, Pieter Wesseling, Roel G W Verhaak
At the time of their clinical manifestation, the heterogeneous group of adult and pediatric gliomas carries a wide range of diverse somatic genomic alterations, ranging from somatic single-nucleotide variants to structural chromosomal rearrangements. Somatic abnormalities may have functional consequences, such as a decrease, increase or change in mRNA transcripts, and cells pay a penalty for maintaining them. These abnormalities, therefore, must provide cells with a competitive advantage to become engrained into the glioma genome...
April 3, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29603080/neuroimaging-classification-of-progression-patterns-in-glioblastoma-a-systematic-review
#12
Rory J Piper, Keerthi K Senthil, Jiun-Lin Yan, Stephen J Price
BACKGROUND: Our primary objective was to report the current neuroimaging classification systems of spatial patterns of progression in glioblastoma. In addition, we aimed to report the terminology used to describe 'progression' and to assess the compliance with the Response Assessment in Neuro-Oncology (RANO) Criteria. METHODS: We conducted a systematic review to identify all neuroimaging studies of glioblastoma that have employed a categorical classification system of spatial progression patterns...
March 30, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29594548/psychiatric-co-morbidity-distress-and-use-of-psycho-social-services-in-adult-glioma-patients-a-prospective-study
#13
Susanne Singer, Julia Roick, Helge Danker, Rolf-Dieter Kortmann, Kirsten Papsdorf, Sabine Taubenheim, Mirjam Renovanz, Katja Jähne, Jürgen Meixensberger
BACKGROUND: Distress impacts the daily life of glioma patients. This study explored its course over time and the usage of psychosocial care. METHODS: A consecutive sample of glioma patients completed the Hospital Anxiety and Depression Scale to assess distress levels at admission to the hospital (t1), before discharge (t2), after 3 months (t3), and after 6 months (t4). They were interviewed with the Structured Clinical Interview for DSM-IV to ascertain psychiatric disorders at t2...
March 29, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29594239/the-posterior-cerebellum-a-new-organ-at-risk
#14
EDITORIAL
Daniëlle B P Eekers, Lieke In 't Ven, Sabine Deprez, Linda Jacobi, Erik Roelofs, Ann Hoeben, Philippe Lambin, Dirk de Ruysscher, Esther G C Troost
Eekers et al. have recently proposed a neuro-oncology atlas, which was co-authored by most centers associated in the European Proton Therapy Network (EPTN; Figure 1). With the introduction of new treatment techniques, such as integrated magnetic resonance imaging and linear accelerators (MR-linac) or particle therapy, the prediction of clinical efficacy of these more costly treatment modalities becomes more relevant. One of the side-effects of brain irradiation, being cognitive decline, is one of the toxicities most difficult to measure and predict...
January 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29590465/population-description-and-clinical-response-assessment-for-spinal-metastases-part-2-of-the-spine-response-assessment-in-neuro-oncology-spino-group-report
#15
Ilya Laufer, Simon S Lo, Eric L Chang, Jason Sheehan, Matthias Guckenberger, Moon-Jun Sohn, Samuel Ryu, Matthew Foote, Alexander Muacevic, Scott G Soltys, Samuel Chao, Sten Myrehaug, Peter C Gerszten, Eric Lis, Pejman Maralani, Mark Bilsky, Charles Fisher, Laurence Rhines, Jorrit-Jan Verlaan, David Schiff, Michael G Fehlings, Lijun Ma, Susan Chang, Wendy R Parelukar, Michael A Vogelbaum, Arjun Sahgal
Background: Approximately 40% of metastatic cancer patients will develop spinal metastases. The current report provides recommendations for standardization of metrics used for spinal oncology patient population description and outcome assessment beyond local control endpoints on behalf of the SPIne response assessment in Neuro-Oncology (SPINO) group. Methods: SPINO group survey was conducted in order to determine the preferences for utilization of clinician-based and patient-reported outcome measures for description of patients with spinal metastases...
March 24, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29570033/taking-the-next-step-in-publication-productivity-analysis-in-pediatric-neurosurgery
#16
Ryan P Lee, Raymond Xu, Pooja Dave, Sonia Ajmera, Jock C Lillard, David Wallace, Austin Broussard, Mustafa Motiwala, Sebastian Norrdahl, Carissa Howie, Oluwatomi Akinduro, Garrett T Venable, Nickalus R Khan, Douglas R Taylor, Brandy N Vaughn, Paul Klimo
OBJECTIVE There has been an increasing interest in the quantitative analysis of publishing within the field of neurosurgery at the individual, group, and institutional levels. The authors present an updated analysis of accredited pediatric neurosurgery training programs. METHODS All 28 Accreditation Council for Pediatric Neurosurgery Fellowship programs were contacted for the names of pediatric neurosurgeons who were present each year from 2011 through 2015. Faculty names were queried in Scopus for publications and citations during this time period...
March 23, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29559080/analysis-of-scientific-production-in-otolaryngology-in-spain-in-the-period-2011-2015
#17
Jose A Lopez-Escamez, Raquel Manrique-Huarte, Eduardo Martin-Sanz, Gabriel Trinidad
INTRODUCTION: Publishing in scientific journals is an indicator of hospital quality and has become a standard of excellence for medical doctors and institutions. The aim of the study is to identify the scientific publications performed by Otolaryngology Departments in Spain within the period 2011-2015 and to compare them to a previous period between 1998-2002. MATERIAL AND METHODS: Original papers published by Otolaryngology Departments in Spain in PubMed within 2011-2015 were retrieved...
March 17, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29550414/amantadine-induced-corneal-edema-in-a-pediatric-neuro-oncology-patient-a-case-report
#18
Maria Beran, Britta Okyere, Joshua Vova
No abstract text is available yet for this article.
March 14, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29548560/the-eptn-consensus-based-atlas-for-ct-and-mr-based-contouring-in-neuro-oncology
#19
Daniëlle Bp Eekers, Lieke In 't Ven, Erik Roelofs, Alida Postma, Claire Alapetite, Neil G Burnet, Valentin Calugaru, Inge Compter, Ida E M Coremans, Morton Høyer, Maarten Lambrecht, Petra Witt Nyström, Alejandra Méndez Romero, Frank Paulsen, Ana Perpar, Dirk de Ruysscher, Laurette Renard, Beate Timmermann, Pavel Vitek, Damien C Weber, Hiske L van der Weide, Gillian A Whitfield, Ruud Wiggenraad, Esther G C Troost
PURPOSE: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging. METHODS: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published...
March 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29548050/radiomics-metabolic-and-molecular-mri-for-brain-tumors
#20
Philipp Kickingereder, Ovidiu Cristian Andronesi
Magnetic resonance imaging plays a key role in diagnosis and treatment monitoring of brain tumors. Novel imaging techniques that specifically interrogate aspects of underlying tumor biology and biochemical pathways have great potential in neuro-oncology. This review focuses on the emerging role of 2-hydroxyglutarate-targeted magnetic resonance spectroscopy, as well as radiomics and radiogenomics in establishing diagnosis for isocitrate dehydrogenase mutant gliomas, and for monitoring treatment response and predicting prognosis of this group of brain tumor patients...
February 2018: Seminars in Neurology
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