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Neuro oncology

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https://www.readbyqxmd.com/read/29438500/diffusion-radiomics-as-a-diagnostic-model-for-atypical-manifestation-of-primary-central-nervous-system-lymphoma-development-and-multicenter-external-validation
#1
Daesung Kang, Ji Eun Park, Young-Hoon Kim, Jeong Hoon Kim, Joo Young Oh, Jungyoun Kim, Yikyung Kim, Sung Tae Kim, Ho Sung Kim
Background: Radiomics is a rapidly growing field in neuro-oncology, but studies have been limited to conventional MRI and external validation is critically lacking. We evaluated technical feasibility, diagnostic performance, and generalizability of a diffusion radiomics model for identifying atypical primary central nervous system lymphoma (PCNSL) mimicking glioblastoma. Methods: Total 1618 radiomics features were extracted from diffusion and conventional MRI from 112 patients (training set, 70 glioblastomas and 42 PCNSLs)...
February 9, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29433183/quality-of-life-after-craniovertebral-junction-meningioma-resection-shaping-the-real-neurologic-and-functional-expectancies-about-these-surgeries-in-a-contemporary-large-multicenter-experience
#2
Antonino Raco, Alessandro Pesce, Giada Toccaceli, Alessandro Frati, Demo Eugenio Dugoni, Roberto Delfini
OBJECTIVE: Craniovertebral junction (CVJ) meningiomas are one of the most surgically complex conditions in neuro-oncologic surgery. The aim of this work is to correlate our data with clinical outcome to outline factors leading to a worse functional prognosis. METHODS: We analyzed sex, age, clinical presentation, topography, surgical approach, Simpson grade resection, postoperative lower cranial nerve deficits, consistency, histology, site of origin, presence of a capsule, and radiologic and clinical follow-up at 1, 6, and 12 months of 61 patients affected by CVJ meningiomas, operated on in our institution from 1992 to 2014...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29428980/bone-flap-salvage-in-acute-surgical-site-infection-after-craniotomy-for-tumor-resection
#3
David J Wallace, Michael J McGinity, John R Floyd
Craniotomy surgical site infections are an inherent risk and dreaded complication for the elective brain tumor patient. Sequelae can include delays in resumption in adjuvant treatments for multiple surgeries if staged cranioplasty is pursued. Here, the authors review their experience in operative debridement of surgical site infections with single-stage reimplantation of the salvaged craniotomy bone flap. A prospectively maintained database of a single surgeon's neuro-oncology patients from 2009 to 2017 (JRF) was queried to identify 11 patients with surgical site infection after craniotomy for tumor resection...
February 10, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29417400/pediatric-neuro-oncology-survival-disparities-in-california
#4
Tabitha Cooney, Paul G Fisher, Li Tao, Christina A Clarke, Sonia Partap
The objective of this study was to investigate racial/ethnic differences in survival for pediatric high-grade glioma (HGG) and medulloblastoma in the state of California. We obtained data from the California Cancer Registry on 552 high-grade glioma patients (110 brainstem, 442 non-brainstem) and 648 medulloblastoma patients ages 0-19 years from 1988 to 2012. Using multivariate Cox proportional hazards regression, we examined the impact of individual and neighborhood characteristics on survival. Socioeconomic quintile and insurance status differed significantly by race for both diagnoses...
February 7, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29410102/laser-induced-thermal-therapy-in-neuro-oncology-a-review
#5
REVIEW
Omar Ashraf, Nitesh V Patel, Simon Hanft, Shabbar F Danish
Laser therapy has become an appealing treatment modality in neurosurgery. With the advent of real-time monitoring and damage estimation, laser induced thermal therapy (LITT) has gained ground in the management of intracranial tumors. In the past decade multiple studies have demonstrated the use, outcomes, and complications associated with LITT in neurosurgery. These same studies have consistently reported an overall benefit of LITT in cases where traditional surgical approaches may be limited by the patient's clinical status, tumor location, or overall prognosis...
February 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29402600/tumour-volume-and-dose-influence-outcome-after-surgery-and-high-dose-photon-radiotherapy-for-chordoma-and-chondrosarcoma-of-the-skull-base-and-spine
#6
E R Gatfield, D J Noble, G C Barnett, N Y Early, A C F Hoole, N F Kirkby, S J Jefferies, N G Burnet
AIMS: To evaluate the long-term outcomes of patients with chordoma and low-grade chondrosarcoma after surgery and high-dose radiotherapy. MATERIALS AND METHODS: High-dose photon radiotherapy was delivered to 28 patients at the Neuro-oncology Unit at Addenbrooke's Hospital (Cambridge, UK) between 1996 and 2016. Twenty-four patients were treated with curative intent, 17 with chordoma, seven with low-grade chondrosarcoma, with a median dose of 65 Gy (range 65-70 Gy)...
February 2, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29401154/bereaved-caregivers-to-patients-with-high-grade-glioma-a-qualitative-explorative-study
#7
Karin Piil, Mary Jarden
PURPOSE: The disease and treatment trajectory of patients with high-grade glioma is a burdensome period for the patients' closest relatives who become informal caregivers. Caregivers experiencing this demanding shift in role are at risk of developing symptoms such as depression. Few studies have explored the needs and experiences of bereaved caregivers, and there is lack of evidence-based practice. This study explores the perspectives of newly bereaved caregivers to patients with high-grade glioma on end-of-life caregiving and bereavement...
February 2, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29393189/palliative-and-supportive-care-of-patients-with-intracranial-glioma
#8
Andrea Pace, Veronica Villani
Clinicians dealing with patients affected by malignant brain tumors are frequently involved in providing palliative and supportive care, particularly at the end of life. It requires a multidisciplinary approach by a well-trained specialized neuro-oncology team. Early initiation of palliative care integrated with standard anticancer therapy may be effective for symptom management and results in improvement of the quality of life. However, studies specifically addressing these issues are very limited, thus do not allow the creation of any reliable evidence-based guidelines...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29392590/a-time-of-transition-in-the-journal-of-neuro-oncology
#9
EDITORIAL
Jason Sheehan
No abstract text is available yet for this article.
February 1, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29391365/social-and-structural-conditions-for-the-avoidance-of-advance-care-planning-in-neuro-oncology-a-qualitative-study
#10
Henry Llewellyn, Jane Neerkin, Lewis Thorne, Elena Wilson, Louise Jones, Elizabeth L Sampson, Emma Townsley, Joseph T S Low
BACKGROUND: Primary brain tumours newly affect >260 000 people each year worldwide. In the UK, every year >10 000 people are diagnosed with a brain tumour while >5000 die annually from the disease. Prognoses are poor, cognitive deterioration common and patients have prolonged palliative needs. Advance care planning (ACP) may enable early discussion of future care decisions. Although a core commitment in the UK healthcare strategy, and the shared responsibility of clinical teams, ACP appears uncommon in practice...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29390139/maintaining-quality-of-life-near-the-end-of-life-hospice-in-neuro-oncology
#11
Tobias Walbert
No abstract text is available yet for this article.
January 30, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29378419/clinical-importance-of-eflornithine-%C3%AE-difluoromethylornithine-for-the-treatment-of-malignant-gliomas
#12
Victor A Levin, Sandra E Ictech, Kenneth R Hess
This review covers the literature between 1989 and 2007 on studies relevant to the neuro-oncology usage of eflornithine (α-difluoromethylornithine), an oral agent that irreversibly inhibits the enzyme ornithine decarboxylase. It covers the use of eflornithine, alone or in combination, to treat high-grade gliomas. In addition, we provide an update on overall survival from The University of Texas MD Anderson Cancer Center Community Clinical Oncology Program and Clinical Trials Data Office that demonstrates a meaningful benefit in overall survival for eflornithine as a single agent and in combination with nitrosourea-based therapies for anaplastic gliomas...
January 30, 2018: CNS Oncology
https://www.readbyqxmd.com/read/29373207/karakousis-s-abdominoinguinal-approach-for-the-treatment-of-a-primary-retroperitoneal-parasitic-leiomyoma-with-inguinal-extension-a-case-report
#13
Alberto Gomez Portilla, Victor Echenagusía, Iñaki Cendoya, Aintzane Maqueda, Eduardo López de Heredia
INTRODUCTION: Primary retroperitoneal parasitic leiomyoma (PRPL) with inguinal extension is a diagnostic-therapeutic challenge due to its uncertain etiopathogenesis and because it has been considered unresectable according to customary surgical techniques in some instances. The abdominoinguinal incision described by Karakousis in the 1980s allows a safe and radical approach for lower quadrants abdominopelvic tumors. OBJECTIVES: We present the case of a rare PRPL satisfactorily treated through Karakousis's approach...
January 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29365203/meeting-update-society-for-neuro-oncology-2017-annual-meeting
#14
Roy E Strowd, Albert H Kim, Patrick Y Wen
No abstract text is available yet for this article.
January 22, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29361284/intraoperative-3-tesla-magnetic-resonance-imaging-our-experience-in-tumors
#15
A García-Baizán, A Tomás-Biosca, P Bartolomé Leal, P D Domínguez, R García de Eulate Ruiz, S Tejada, J L Zubieta
OBJECTIVE: To report our experience in the use of 3 tesla intraoperative magnetic resonance imaging (MRI) in neurosurgical procedures for tumors, and to evaluate the criteria for increasing the extension of resection. MATERIAL AND METHODS: This retrospective study included all consecutive intraoperative MRI studies done for neuro-oncologic disease in the first 13 months after the implementation of the technique. We registered possible immediate complications, the presence of tumor remnants, and whether the results of the intraoperative MRI study changed the surgical management...
January 17, 2018: Radiología
https://www.readbyqxmd.com/read/29356927/image-guided-resection-of-glioblastoma-in-eloquent-brain-areas-facilitated-by-laser-surface-thermal-therapy-clinical-outcomes-and-long-term-results
#16
Artem Rozumenko, Valentyn Kliuchka, Volodymir Rozumenko, Vera Semenova, Sergii Kolesnyk, Zoja Fedorenko
The increased interest in the application of lasers in neuro-oncology prompted us to present our experience of using the laser technologies in the treatment of cerebral gliomas. The aim of the study was to evaluate the clinical efficacy of image-guided laser surface thermal therapy (LSTT) and its influence on survival of patients with glioblastoma (GBM).Data of 91 patients (49 males, 42 females, mean age 51.4 years, range 23-70 years) with supratentorial GBMs located in close vicinity to or within the eloquent brain areas were retrospectively analyzed...
January 22, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29355914/intraoperative-imaging-technology-to-maximise-extent-of-resection-for-glioma
#17
REVIEW
Michael D Jenkinson, Damiano Giuseppe Barone, Andrew Bryant, Luke Vale, Helen Bulbeck, Theresa A Lawrie, Michael G Hart, Colin Watts
BACKGROUND: Extent of resection is considered to be a prognostic factor in neuro-oncology. Intraoperative imaging technologies are designed to help achieve this goal. It is not clear whether any of these sometimes very expensive tools (or their combination) should be recommended as standard care for people with brain tumours. We set out to determine if intraoperative imaging technology offers any advantage in terms of extent of resection over standard surgery and if any one technology was more effective than another...
January 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29352231/the-direction-of-tumour-growth-in-glioblastoma-patients
#18
Morteza Esmaeili, Anne Line Stensjøen, Erik Magnus Berntsen, Ole Solheim, Ingerid Reinertsen
Generating MR-derived growth pattern models for glioblastoma multiforme (GBM) has been an attractive approach in neuro-oncology, suggesting a distinct pattern of lesion spread with a tendency in growing along the white matter (WM) fibre direction for the invasive component. However, the direction of growth is not much studied in vivo. In this study, we sought to study the dominant directions of tumour expansion/shrinkage pre-treatment. We examined fifty-six GBMs at two time-points: at radiological diagnosis and as part of the pre-operative planning, both with contrast-enhanced T1-weighted MRIs...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29340286/cancer-imaging-phenomics-toolkit-quantitative-imaging-analytics-for-precision-diagnostics-and-predictive-modeling-of-clinical-outcome
#19
Christos Davatzikos, Saima Rathore, Spyridon Bakas, Sarthak Pati, Mark Bergman, Ratheesh Kalarot, Patmaa Sridharan, Aimilia Gastounioti, Nariman Jahani, Eric Cohen, Hamed Akbari, Birkan Tunc, Jimit Doshi, Drew Parker, Michael Hsieh, Aristeidis Sotiras, Hongming Li, Yangming Ou, Robert K Doot, Michel Bilello, Yong Fan, Russell T Shinohara, Paul Yushkevich, Ragini Verma, Despina Kontos
The growth of multiparametric imaging protocols has paved the way for quantitative imaging phenotypes that predict treatment response and clinical outcome, reflect underlying cancer molecular characteristics and spatiotemporal heterogeneity, and can guide personalized treatment planning. This growth has underlined the need for efficient quantitative analytics to derive high-dimensional imaging signatures of diagnostic and predictive value in this emerging era of integrated precision diagnostics. This paper presents cancer imaging phenomics toolkit (CaPTk), a new and dynamically growing software platform for analysis of radiographic images of cancer, currently focusing on brain, breast, and lung cancer...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29337169/the-prognostic-role-of-gender-and-mgmt-methylation-status-in-glioblastoma-patients-the-female-power
#20
Enrico Franceschi, Alicia Tosoni, Santino Minichillo, Roberta Depenni, Alexandro Paccapelo, Stefania Bartolini, Maria Michiara, Giacomo Pavesi, Benedetta Urbini, Girolamo Crisi, Michele A Cavallo, Luigino Tosatto, Claudio Dazzi, Claudia Biasini, Giuseppe Pasini, Damiano Balestrini, Francesca Zanelli, Vania Ramponi, Antonio Fioravanti, Ermanno Giombelli, Dario De Biase, Agostino Baruzzi, Alba A Brandes
BACKGROUND: Clinical and molecular factors are essential to define prognosis in glioblastoma (GBM) patients. MGMT methylation status, age, Karnofsky performance status (KPS) and extent of surgical resection are the most relevant prognostic factors. The role of gender in predicting patients prognosis has been investigated showing a slight survival advantage for female patients. METHODS: We performed a prospective evaluation from a registry called the Project of Emilia Romagna on Neuro-Oncology (PERNO) about prognostic factors in GBM patients who received standard treatment...
January 11, 2018: World Neurosurgery
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