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Recurrent Thyroid Cancer

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https://www.readbyqxmd.com/read/28927041/anastomosis-in-the-absence-of-a-suprahyoid-release-following-circumferential-sleeve-resection-is-feasible-in-differentiated-thyroid-carcinoma-patients-with-tracheal-invasion
#1
Wanjun Chen, Shujuan Zou, Liang Wang, Changhua Wu, Zhiqi Wang, Ke Li, Shuguang Zhang
Invasion of the trachea is observed in ~6% of patients with differentiated thyroid carcinoma (DTC), and surgery is accepted as the treatment of choice. However, surgical procedures can be challenging and are associated with various risks. The authors of the present study performed a retrospective study of patients with DTC and tumor invasion of the trachea. Outcomes from patients that received circumferential sleeve resection (CSR) of the trachea followed by anastomosis in the absence of suprahyoid release (n=21; CSR group) and patients that underwent tangential resections [n=103; tangential 'shave' resection (TSR) group) were analyzed...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28919092/cervical-soft-tissue-recurrence-of-differentiated-thyroid-carcinoma-after-thyroidectomy-indicates-a-poor-prognosis
#2
Luying Gao, Yuxin Jiang, Zhiyong Liang, Lei Zhang, Xinxin Mao, Xiao Yang, Ying Wang, Jingzhu Xu, Ruyu Liu, Shenling Zhu, Ruina Zhao, Xingjian Lai, Xiaoyan Zhang, Bo Zhang
BACKGROUND: We investigated cervical soft tissue recurrence of differentiated thyroid carcinoma (DTC) after thyroidectomy, and these lesions exhibited no evidence that they were lymph nodes (LNs). METHODS: Between January 2012 and April 2016, consecutive 6308 patients underwent thyroid surgery for DTC at our center. Among them, we encountered 21 patients with recurrent cervical soft tissue lesions, none of whom had previously undergone fine needle aspiration biopsy (FNAB)...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28914637/signal-transducer-and-activator-of-transcription-gain-of-function-primary-immunodeficiency-immunodysregulation-disorders
#3
Filippo Consonni, Laura Dotta, Francesca Todaro, Donatella Vairo, Raffaele Badolato
PURPOSE OF REVIEW: To describe primary immunodeficiencies caused by gain-of-function (GOF) mutations of signal transducer and activator of transcription (STAT) genes, a group of genetically determined disorders characterized by susceptibility to infections and, in many cases, autoimmune manifestations. RECENT FINDINGS: GOF mutations affecting STAT1 result in increased STAT tyrosine phosphorylation and secondarily increased response to STAT1-signaling cytokines, such as interferons...
September 13, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28912377/immune-response-in-the-thyroid-cancer-microenvironment-making-immunotherapy-a-possible-mission
#4
Robert C Mould, Jacob P van Vloten, Amanda W K AuYeung, Khalil Karimi, Byram W Bridle
The incidence of thyroid cancers has been steadily increasing worldwide over the past few decades. Although five-year survival rates for differentiated thyroid cancers are upwards of 90%, clinical outcomes for patients with undifferentiated, recurrent and/or metastatic disease are often dismal despite conventional interventions. As such, there is a demand for novel treatment options. Cancer immunotherapy represents the ultimate form of personalized medicine by leveraging the specificity and potency of a patient's immune system to kill their tumour...
September 14, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28911725/which-patient-with-thyroid-cancer-deserves-systemic-therapy-and-when
#5
REVIEW
Furio Pacini
Distant metastases from differentiated thyroid cancer (DTC) are a rare event, occurring in less than 10% of patients with persistent or recurrent clinical disease. About 50% of these patients do respond to radioiodine (RAI) therapy, either with complete remission or stabilization of the disease on a long term period. Unfortunately, another 50% of these patients are refractory to the treatment with RAI, either from the first appearance of distant metastases or during follow-up. Overall, these patients represent 4-5 new cases/year/million...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28910916/-primary-tracheal-malignant-glomus-tumor-with-lung-metastasis-diagnosed-by-pathological-analysis-a-case-report-and-literature-review
#6
B Huang, F G Chen, J Zhuang, W C Zheng, W Y Zhu, Q C Zhang, S H Wang, C M Guo, C M Xie
Objective: To study the clinical manifestations, pathological features, diagnosis, differential diagnosis, treatment and prognosis of primary tracheobronchial or pulmonary malignant glomus tumor (MGT). Methods: A case of primary tracheal MGT with lung metastasis diagnosed by pathological analysis admitted to Affiliated Shantou Hospital of Sun Yat-sen University in May. 2015 was analyzed, and the related literatures were reviewed. We searched databases including PubMed, Embase, Ovid, Cochrane, Wanfang and Chinese National Knowledge infrastructure (CNKI), using the keyword "tracheal or bronchial or pulmonary malignant glomus tumor" from Jan...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28902626/pediatric-differentiated-thyroid-carcinoma-trends-in-practice-and-outcomes-over-40-years-at-a-single-tertiary-care-institution
#7
Courtney Olmsted, Rajalakshmi Arunachalam, Xiang Gao, Liuska Pesce, Geeta Lal
BACKGROUND: This study aims to analyze changes in characteristics, practice and outcomes of pediatric differentiated thyroid cancer (DTC) at our tertiary care institution. METHODS: Patients <21 years of age diagnosed between 1973 and 2013 were identified. Clinicopathological data, treatment and outcomes were obtained by a retrospective review. RESULTS: Thirteen males and 68 females were divided into Group A (n=35, diagnosed before July 1993) and Group B (n=46, diagnosed after July 1993)...
September 13, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28901320/thyroid-carcinoma-in-children-and-adolescents-clinical-characteristics-and-follow-up-from-two-centers
#8
Jing-Jing Pan, Li Zhao, Rui Cheng, Yang Yang, Yu-Hua Hu
AIM OF STUDY: The aim of this study was to analyze the clinical features and outcomes of thyroid carcinoma (TC) in children and adolescent population treated in our institution. MATERIALS AND METHODS: We gathered 43 TC patients 18 years of age or under initial diagnosed between 2009 and 2010 from two hospitals. Patient's clinical characteristics, laboratory tests, and outcomes were collected and analyzed. RESULTS: (1) The incidence of TC is higher in women (2...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28881423/thyroid-cancer-mortality-is-higher-in-filipinos-in-the-united-states-an-analysis-using-national-mortality-records-from-2003-through-2012
#9
Michelle-Linh T Nguyen, Jiaqi Hu, Katherine G Hastings, Eric J Daza, Mark R Cullen, Lisa A Orloff, Latha P Palaniappan
BACKGROUND: Well-differentiated thyroid carcinoma has a favorable prognosis, but patients with multiple recurrences have drastically lower survival. Filipinos in the United States are known to have high rates of thyroid cancer incidence and disease recurrence. To the authors' knowledge, it is unknown whether Filipinos also have higher thyroid cancer mortality rates. METHODS: The authors studied thyroid cancer mortality in Filipino, non-Filipino Asian (NFA), and non-Hispanic white (NHW) adults using US death records (2003-2012) and US Census data...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28879559/yonsei-experience-of-5000-gasless-transaxillary-robotic-thyroidectomies
#10
Min Jhi Kim, Kee-Hyun Nam, Seul Gi Lee, Jung Bum Choi, Tae Hyung Kim, Cho Rok Lee, Jandee Lee, Sang-Wook Kang, Jong Ju Jeong, Woong Youn Chung
BACKGROUND: Since the use of robot systems in thyroid surgery was introduced in 2007, we have advanced a novel method of robotic thyroidectomy (RT) using a gasless transaxillary approach (TAA). We report our experience with this technique and detail the surgical outcome of 5000 robotic thyroidectomies. METHODS: From October 2007 to May 2016, we successfully performed 5000 robotic thyroidectomies using a gasless TAA at the Department of Surgery, Yonsei University Health System...
September 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28874622/predictors-of-central-lymph-node-metastasis-in-papillary-thyroid-cancer
#11
Huseyin Celik, Ozgur Akgul, Barıs Dogu Yıldız, Barıs Saylam, Mesut Tez
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland and although PTC has excellent prognosis, central lymph node (CLN) metastases are not uncommon. Studies have shown that CLN metastases are associated with an increased recurrence rate. The necessity for prophylactic CLN dissection (pCCND) in clinical lymph node negative (cN0) patients remains controversial. The aim of this study was to determine predictors of CLN metastases in cN0 PTC patients who underwent prophylactic CLN dissection...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28874092/anxiety-and-fear-of-recurrence-despite-a-good-prognosis-an-interview-study-with-differentiated-thyroid-cancer-patients
#12
Christel Hedman, Peter Strang, Therese Djärv, Ida Widberg, Catharina Ihre Lundgren
BACKGROUND: Despite a good prognosis, fear of recurrence is prevalent even several years after a diagnosis of differentiated thyroid cancer (DTC). For this reason, our aim was to make an in-depth exploration of anxiety, sources of anxiety, and protective strategies. METHODS: In order to capture a broad description of the phenomenon, a purposeful, maximum variation sampling strategy regarding age, gender, stage of disease, educational level and time since diagnosis was used...
September 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28868260/tpoab-and-thyroid-function-are-not-associated-with-breast-cancer-outcome-evidence-from-a-large-scale-study-using-data-from-the-taxotere-as-adjuvant-chemotherapy-trial-tact-cruk01-001
#13
Ilaria Muller, Lucy S Kilburn, Peter N Taylor, Peter J Barrett-Lee, Judith M Bliss, Paul Ellis, Marian E Ludgate, Colin M Dayan
BACKGROUND: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. OBJECTIVES: We aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). METHODS: TACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1-3a, pN0-1, M0), with stored plasma (n = 1,974), taken 15...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868259/radioiodine-ablation-following-thyroidectomy-for-differentiated-thyroid-cancer-literature-review-of-utility-dose-and-toxicity
#14
REVIEW
Nicholas S Andresen, John M Buatti, Hamed H Tewfik, Nitin A Pagedar, Carryn M Anderson, John M Watkins
Management recommendations for differentiated thyroid cancer are evolving. Total thyroidectomy is the backbone of curative-intent therapy, with radioiodine ablation (RAI) of the thyroid remnant routinely performed, in order to facilitate serologic surveillance and reduce recurrence risk. Several single-institution series have identified patient subsets for whom recurrence risk is sufficiently low that RAI may not be indicated. Further, the appropriate dose of RAI specific to variable clinicopathologic presentations remains poorly defined...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868026/ultrasound-guided-transoral-videolaryngoscopic-surgery-for-retropharyngeal-lymph-node-metastasis-of-papillary-thyroid-cancer
#15
Kazunori Fujiwara, Takahiro Fukuhara, Satoshi Koyama, Ryohei Donishi, Hideyuki Kataoka, Hiroya Kitano, Hiromi Takeuchi
BACKGROUND: Endoscopic-assisted transoral surgery, including transoral robotic surgery for metastatic retropharyngeal lymph node (RPN) from well-differentiated thyroid cancer, has been reported to reduce the complications resulting from transcervical and transmandibular approaches. However, the narrow working space and difficulty identifying RPN are problematic. To solve these issues, several studies have used intraoperative ultrasound in endoscopic-assisted transoral surgery. However, the type of ultrasonography suitable for this purpose remains unclear...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28864536/changes-in-the-clinicopathological-characteristics-and-genetic-alterations-of-follicular-thyroid-cancer
#16
Young Shin Song, Jung Ah Lim, Hye Sook Min, Min Joo Kim, Hoonsung Choi, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
OBJECTIVE: Changes in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer (FTC) over time have not been reported. Moreover, the prognostic effects of RAS and TERT promoter mutations in FTC have not been clearly elucidated. We investigated changes in the clinicopathological characteristics of patients with FTC over four decades, as well as the clinical significance of genetic mutations of FTC. DESIGN AND METHODS: This retrospective study included 690 patients with FTC who underwent thyroidectomy between 1973 and 2015 at the Seoul National University Hospital...
September 1, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28858125/langerhans-cell-histiocytosis-of-the-thyroid-complicated-by-papillary-thyroid-carcinoma-a-case-report-and-brief-literature-review
#17
REVIEW
Xin Wu, Shi Chen, Li-Yang Zhang, Ya-Ping Luo, Ying Jiang, Rui-E Feng
RATIONALE: Langerhans cell histiocytosis (LCH) involves mainly the skin and bone and rarely the thyroid. Meanwhile, papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Both LCH and PTC could make the thyroid enlarged and hypermetabolic. The coincidence of these 2 events in a patient is rare, and this paper aimed to report such case. PATIENT CONCERNS: A 40-year-old man presented with polyuria and polydipsia for 5 years. The symptoms had been relieved well by drug therapy for >4 years, until the drugs could not control the symptoms anymore and an extensively enlarged thyroid gland was noticed...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28851261/do-lower-risk-thyroid-cancer-patients-who-live-in-regions-with-more-aggressive-treatments-have-better-outcomes
#18
Stephen Hall, Jonathan C Irish, Patti A Groome, Rebecca Griffiths, David Hurlbut
BACKGROUND: The management of differentiated thyroid cancer has traditionally consisted of total thyroidectomy with or without adjuvant radioactive iodine. However, in the last two decades this approach has been challenged with the consideration of more conservative approaches such as less radical surgery and deferring adjuvant treatment especially in lower risk patients. The objective of this study was to compare the effectiveness of current treatment options by comparing the survival outcomes from different geographic regions with different treatment philosophies...
August 29, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28822118/risk-factors-for-lateral-neck-recurrence-of-n0-n1a-papillary-thyroid-cancer
#19
Yehree Kim, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Current guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b. METHODS: The study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b...
August 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28821573/dynamic-risk-stratification-in-the-follow-up-of-thyroid-cancer
#20
Jolanta Krajewska, Ewa Chmielik, Barbara Jarzab
The adequate risk stratification in thyroid carcinoma, is crucial to avoid on one hand the overtreatment of low-risk and on the other hand the undertreatment of high-risk patients. The question how to properly assess the risk of relapse has been discussed during recent years and resulted in a substantial change in our approach to risk stratification in differentiated thyroid cancer, proposed by the newest ATA guidelines. First initial risk stratification, based on histopathological data is carried out just after primary surgery...
August 18, 2017: Endocrine-related Cancer
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