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Recurrent Thyroid Cancer

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https://www.readbyqxmd.com/read/28545571/survival-and-prognostic-factors-for-survival-cancer-specific-survival-and-disease-free-interval-in-239-patients-with-hurthle-cell-carcinoma-a-single-center-experience
#1
Branisav Oluic, Ivan Paunovic, Zlatibor Loncar, Vladimir Djukic, Aleksandar Diklic, Milan Jovanovic, Zeljko Garabinovic, Nikola Slijepcevic, Branislav Rovcanin, Dusan Micic, Aleksandar Filipovic, Vladan Zivaljevic
BACKGROUND: Hurthle cell carcinoma makes up 3 to 5% of all thyroid cancers and is considered to be a true rarity. The aim of our study was to analyze clinical characteristics and survival rates of patients with Hurthle cell carcinoma. METHODS: Clinical data regarding basic demographic characteristics, tumor grade, type of surgical treatment and vital status were collected. Methods of descriptive statistics and Kaplan-Meier survival curves were used for statistical analysis...
May 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28545338/radiofrequency-ablation-of-small-follicular-neoplasms-initial-clinical-outcomes
#2
Su Min Ha, Jin Yong Sung, Jung Hwan Baek, Dong Gyu Na, Ji-Hoon Kim, Hyunju Yoo, Ducky Lee, Dong Whan Choi
BACKGROUND: In thyroid gland, radiofrequency ablation (RFA) has been applied to both recurrent cancers and benign nodules, although, according to the American Thyroid Association (ATA) and the Korean Society of Thyroid Radiology (KSThR) guidelines, surgery is the first-line treatment for follicular neoplasm. However, it has been argued that follicular neoplasm with lower risk of malignancy can be managed by close follow-up. In this study, we evaluated the effectiveness of RFA of small follicular neoplasms, examining reductions in volume and related clinical problems, and making observations over long-term follow-up...
May 25, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28545026/identification-of-novel-long-non-coding-rna-biomarkers-for-prognosis-prediction-of-papillary-thyroid-cancer
#3
Qiuying Li, Haihong Li, Lu Zhang, Chunming Zhang, Wentao Yan, Chao Wang
Papillary thyroid carcinoma (PTC) is the most frequent type of malignant thyroid tumor. Several lncRNA signatures have been established for prognosis prediction in some cancers. However, the prognostic value of lncRNAs has not been investigated in PTC yet. In this study, we performed genome-wide analysis of lncRNA expression profiles in a large cohort of PTC patients from The Cancer Genome Atlas and identified 111 differentially expressed lncRNAs between tumor and non-tumor samples and between recurrent and recurrence-free samples...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28543974/neck-sonography-and-suppressed-thyroglobulin-have-high-sensitivity-for-identifying-recurrent-persistent-disease-in-patients-with-low-risk-thyroid-cancer-treated-with-total-thyroidectomy-and-radioactive-iodine-ablation-making-stimulated-thyroglobulin-unnecessary
#4
José M Domínguez, Flavia Nilo, Tania Contreras, Rocío Carmona, Nicolás Droppelmann, Hernán González, Virginia Iturrieta, R Michael Tuttle
OBJECTIVES: Follow-up of patients with low-risk differentiated thyroid cancer treated with total thyroidectomy and radioiodine requires neck sonography and thyroglobulin (Tg). The need to stimulate Tg is controversial. The goal of this study was to compare the diagnostic performances of sonography plus suppressed or stimulated Tg in low-risk thyroid cancer. METHODS: After total thyroidectomy and radioiodine, patients with low-risk thyroid cancer were retrospectively identified as having structural or biochemical persistence/recurrence...
May 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28528434/tall-cell-and-diffuse-sclerosing-variants-of-papillary-thyroid-cancer-outcome-and-predicting-value-of-risk-stratification-methods
#5
M Russo, P Malandrino, M Moleti, F Vermiglio, M A Violi, I Marturano, E Minaldi, R Vigneri, G Pellegriti, C Regalbuto
PURPOSE: Tall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification. METHODS: A consecutive series of DSV (n = 54), TCV (n = 72) and cPTC (n = 184) patients was retrospectively analyzed. TCV and DSV patients were first risk stratified for recurrent/persistent disease without considering the histotype as a risk factor and subsequently, 6-24 months after initial treatment, re-classified on the basis of the response to therapy (ongoing risk stratification)...
May 20, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28523362/transoral-endoscopic-thyroidectomy-our-initial-experience-using-a-new-endoscopic-technique
#6
Jun-Ook Park, Dong-Il Sun
BACKGROUND: A transoral approach has been experimentally introduced to the field of thyroid surgery and several groups in Asia have recently used the technique to treat patients. We performed transoral endoscopic thyroidectomies on patients with thyroid cancer or a benign tumor. METHODS: We reviewed the medical records of patients who underwent transoral endoscopic thyroid surgery between July 2016 and January 2017. A midline incision was made in the vestibule, and a 10 mm cannula was placed; then, the working space was widened by insufflating CO2 at a pressure of 5-6 mmHg...
May 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28521635/pathologic-characteristics-natural-history-and-prognostic-implications-of-braf-v600e-mutation-in-pediatric-papillary-thyroid-carcinoma
#7
Steven Hardee, Manju L Prasad, Pei Hui, Catherine A Dinauer, Raffaella A Morotti
The BRAF(V600E) mutation is the most common genetic aberration in papillary thyroid cancer (PTC), found in up to 68% of PTC in adults where it is associated with aggressive features. The incidence of this mutation in pediatric PTC is less frequent, reported as 0%-20% in the past and up to 63% in one recent series. Data suggest the mutation is not associated with an aggressive course in children; however, there are limited numbers of reported case series, so the prognostic implications remain poorly understood...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28521439/arteriovenous-malformation-and-thyroid-metastasis-from-underlying-renal-cell-carcinoma-an-unusual-presentation-of-malignancy-a-case-report
#8
H J Albandar, E S Roberto, J R H See, J H Sabiers
Renal Clear Cell Carcinoma (RCC) comprises over 80% of renal malignancies in adults. Thyroid gland metastasis is rare in RCC. Few studies have described cases of RCC mistaken for benign arteriovenous malformation (AVM). To the best of our knowledge, an AVM arising from underlying RCC metastasis to the brain has not yet been reported. The current study presents a case of RCC metastasis to the thyroid gland, with an AVM identified to be a result of metastatic involvement in the brain. A 45-year-old African-American female presented with left-sided weakness, slurred speech, facial droop and seizure...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28516979/interventional-sialendoscopy-for-radioiodine-induced-sialadenitis-quo-vadis
#9
P Canzi, S Cacciola, P Capaccio, F Pagella, A Occhini, L Pignataro, M Benazzo
Salivary gland toxicity is a common adverse effect of radioactive iodine ((131)I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the (131)I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis...
April 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28516448/management-and-outcome-of-clinically-evident-neck-recurrence-in-patients-with-papillary-thyroid-cancer
#10
Laura Y Wang, Jocelyn C Migliacci, R Michael Tuttle, Ashok R Shaha, Jatin P Shah, Snehal G Patel, Ian Ganly
BACKGROUND: The aim of this study was to report our incidence of clinically evident neck recurrence, salvage neck management and subsequent outcomes in patients with papillary thyroid cancer. This is important to know so that patients with thyroid cancer can be properly councelled about the implications of recurrent disease and subsequent outcome. METHODS: An institutional database of 3664 patients with thyroid cancer operated between 1986 and 2010 was reviewed...
May 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28513128/clinical-features-of-recently-diagnosed-papillary-thyroid-carcinoma-in-elderly-patients-aged-65-and-older-based-on-10-years-of-sonographic-experience-at-a-single-institution-in-korea
#11
Eun Sil Kim, Younghen Lee, Hyungsuk Seo, Gil Soo Son, Soon Young Kwon, Young-Sik Kim, Ji-A Seo, Nan Hee Kim, Sang-Il Suh, Inseon Ryoo, Sung-Hye You
Purpose: The aim of this study was to assess the characteristics of papillary thyroid carcinoma (PTC) in patients aged 65 and older in order to predict postoperative recurrence based on the results of ultrasonographic surveillance. Methods: Among 1,494 patients (200 male and 1,294 female; mean age, 46.6±11.3 years) who underwent surgery for thyroid cancer at our institution between 2006 and 2015, we retrospectively enrolled 150 PTC patients (29 male and 121 female; mean age, 69...
April 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28510799/practical-surgical-techniques-for-lymphadenectomy-along-the-right-recurrent-laryngeal-nerve-during-thoracoscopic-esophagectomy-in-the-prone-position
#12
Taro Oshikiri, Tetsu Nakamura, Yukiko Miura, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Yoshiko Matsuda, Takeru Matsuda, Yasuo Sumi, Satoshi Suzuki, Yoshihiro Kakeji
BACKGROUND: In esophageal squamous cell cancer (SCC), lymphadenectomy along the right recurrent laryngeal nerve (RLN) is important for disease control. The metastatic rate was 33% and the 5-year overall survival rate of these patients was 33.3%,1 but the risk of RLN palsy increases.2 We reported a reliable new method ('Pincers Maneuver')3 for lymphadenectomy along the right RLN during thoracoscopic esophagectomy in the prone position (TEP), and hereby present our video, aimed at providing a complete and safe dissection...
May 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28509618/follow-up-of-patients-with-thyroglobulin-antibodies-rising-tg-ab-trend-is-a-risk-factor-for-recurrence-of-differentiated-thyroid-cancer
#13
Siegrid G A de Meer, Wessel M C M Vorselaars, Jakob W Kist, Marcel P M Stokkel, Bart de Keizer, Gerlof D Valk, Inne H M Borel Rinkes, Menno R Vriens
PURPOSE: Differentiated thyroid cancer is the most common endocrine malignancy. Recurrences (5-20%) are the main reason for follow-up. Thyroglobulin (Tg) has proven to be an excellent disease marker, but thyroglobulin-antibodies (Tg-Ab) may interfere with Tg measurement, leading to over or underestimation. It is proposed that the Tg-Ab trend can be used as a marker for disease recurrence, yet few studies define trend and have a long-term follow-up. The objective of our study was to investigate the value of a well-defined Tg-Ab trend as a surrogate marker for disease recurrence during long-term follow-up...
May 16, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28508841/morbidity-of-central-compartment-clearance-comparison-of-lesser-versus-complete-clearance-in-patients-with-thyroid-cancer
#14
Gouri Pantvaidya, Rakesh Katna, Anuja Deshmukh, Deepa Nair, Anil D'Cruz
BACKGROUND: Extent of central compartment neck dissection (CCND) in thyroid cancers has been a debate because of associated morbidity. There have been attempts to reduce the extent of surgery in an attempt to decrease morbidity. PATIENTS AND METHODS: We analyzed the morbidity of CCND from our prospectively maintained surgical morbidity database. CCND was divided into bilateral complete clearance (BCC) and less than complete clearance (LCC). LCC was performed for clinicoradiologically node negative patients...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28506420/update-on-the-role-of-ultrasound-guided-radiofrequency-ablation-for-thyroid-nodule-treatment
#15
Maija Radzina, Vito Cantisani, Madara Rauda, Michael Bachmann Nielsen, Caroline Ewertsen, Ferdinando D'Ambrosio, Peteris Prieditis, Salvatore Sorrenti
Thyroid nodules can be frequently detected in general population, most of them are benign, however malignant cases are rising in the past decades. Ultrasound (US) is the most common imaging modality to assess thyroid nodular lesions, plan patient work-up and guide minimally invasive treatment. The present review paper has been researched to evaluate the current status of radiofrequency ablation (RFA) treatment in order to evaluate indications, techniques, complications, limitations and outcome assessment in benign solid, partially cystic nodules and recurrent malignant nodules...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506414/unintentional-recurrent-laryngeal-nerve-injuries-following-thyroidectomy-is-it-the-surgeon-who-pays-the-bill
#16
REVIEW
C Gambardella, A Polistena, A Sanguinetti, R Patrone, S Napolitano, D Esposito, D Testa, V Marotta, A Faggiano, P G Calò, N Avenia, G Conzo
BACKGROUND: Thyroidectomy is one of the most common intervention in general surgery and, after the turn of the century, its rate has sharply increased, along with a worldwide increased incidence of differentiated thyroid cancers. Therefore, injuries of the recurrent laryngeal nerve have become one of the most frequent cause of surgical malpractice claims, mostly following surgery for benign pathology. MAIN BODY: Even if the incidence of definitive paralysis is generally lower than 3%, during the last 20 years in Italy, the number of claims for damages has sharply raised...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506051/-a-case-of-thyroid-like-follicular-carcinoma-of-the-kidney
#17
Katsuhiro Ito, Hiromitsu Negoro, Masashi Kubota, Hideaki Takada, Toshihiro Magaribuchi, Atsuro Sawada, Shusuke Akamatsu, Takashi Kobayashi, Naoki Terada, Toshinari Yamasaki, Takahiro Inoue, Tomomi Kamba, Yuki Teramoto, Osamu Ogawa
A 51-year-oldwoman with a right renal mass was referredto our hospital. Computedtomographic (CT) scan demonstrated a 30 mm-diameter renal mass with delayed enhancement. She underwent a robotassistedlaparoscopic right partial nephrectomy. The pathological examination showedthat tumor cells with eosinophilic, clear cytoplasm formedtubules of various sizes containing colloid-like material, which resembled the findings of thyroidfollicular carcinoma. The tumor was immunoreactive for vimentin andcytokeratin (CK) 7, whereas it lackedreactivity for thyroidtranscription factor-1 (TTF-1) or thyroglobulin...
April 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28502882/single-incision-endoscopic-thyroidectomy-for-papillary-thyroid-cancer-a-pilot-study
#18
Jinbeom Cho, Yohan Park, Jongmin Baek, Kiyoung Sung
BACKGROUND: Recently, we have reported single incision endoscopic thyroidectomy using an axillary approach with gas inflation (SIET) in cases with benign thyroid tumors to reduce post-operative pain and invasiveness of the conventional endoscopic thyroidectomy. The aim of this study was to present our experiences with SIET for papillary thyroid cancer (PTC). METHODS: Patients who were diagnosed with histologically papillary thyroid carcinoma (≤1 cm) with single, unilateral, and intra-thyroidal lesion and without clinical lymph node metastasis were included...
May 11, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28501122/association-of-patient-age-with-high-risk-pathologic-features-in-papillary-thyroid-cancer
#19
Adam C Niemann, Alexander T Reid, Joshua Smith, James Hammond, Stephanie A DeBolle, Iris Wei, Christopher Soong-Ho Lee, David T Hughes
BACKGROUND: Certain patient demographics and histopathologic features are risk factors for papillary thyroid cancer (PTC) recurrence after initial treatment. Our objective was to determine whether very young age is associated with aggressive pathologic features in patients with PTC. MATERIALS AND METHODS: A retrospective analysis was performed for PTC patients who underwent surgical treatment at the University of Michigan between 2006 and 2012. Patients with known distant metastases were excluded...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28498808/restoration-of-p53-using-the-novel-mdm2-p53-antagonist-apg115-suppresses-dedifferentiated-papillary-thyroid-cancer-cells
#20
Haibo Chen, Dingyuan Luo, Lin Zhang, Xiaofeng Lin, Qiuyun Luo, Hanjie Yi, Jing Wang, Xianglei Yan, Baoxia Li, Yuelei Chen, Xingguang Liu, Hong Zhang, Sheng Liu, Miaozhen Qiu, Dajun Yang, Ningyi Jiang
Dedifferentiated papillary thyroid cancer (DePTC) is characterized by aggressive growth, recurrence, distant metastasis, and resistance to radioactive iodine (RAI) therapy. DePTC is also accompanied by poor prognosis and high early-mortality. Nevertheless, most DePTC cells show intact p53 downstream functionality. In cells with wild-type p53, the murine double minute2 (MDM2) protein interacts with p53 and abrogates its activity. Inhibition of the MDM2-p53 interaction restores p53 activity and leads to cell cycle arrest and apoptosis...
April 24, 2017: Oncotarget
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