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Recurrent Thyroid Cancer

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https://www.readbyqxmd.com/read/29150348/de-novo-head-and-neck-cancer-arising-in-solid-organ-transplantation-recipients-the-asan-medical-center-experience
#1
Marn Joon Park, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Yoon Se Lee
OBJECTIVE: De novo cancers of head and neck area in solid organ transplantation recipients show standardized incidence ratio (SIR) of 3.8. Immunosuppression following transplantation is suggested to play as a crucial factor in pathogenesis of secondary malignancy. Prognosis of head and neck cancer arising in solid organ transplantation recipients is proven to have poor prognosis. The incidence, risk, prognosis, and survival of de novo malignancy of head and neck area in solid organ transplantation recipients in single-tertiary medical center followed up for 20 years...
November 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29146229/evaluating-the-projected-surgical-impact-of-reclassifying-noninvasive-encapsulated-follicular-variant-of-papillary-thyroid-cancer-as-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features
#2
Rajshri Mainthia, Heather Wachtel, Yufei Chen, Elizabeth Mort, Sareh Parangi, Peter M Sadow, Carrie C Lubitz
BACKGROUND: The reclassification of noninvasive encapsulated follicular variant of papillary thyroid cancer to noninvasive follicular thyroid neoplasm with papillary-like nuclear features will reduce nonefficacious and potentially harmful care. Reclassification is estimated in 18.6% of patients with papillary thyroid carcinoma; we aimed to quantify the implications of this change. METHODS: Pathology reports from April 2006 to April 2016 were reviewed to isolate cases that would have been designated as neoplasm with papillary-like nuclear features...
November 13, 2017: Surgery
https://www.readbyqxmd.com/read/29144823/the-relationship-of-braf-v600e-mutation-status-to-fdg-pet-ct-avidity-in-thyroid-cancer-a-review-and-meta-analysis
#3
Prasanna Santhanam, Rodhan Khthir, Lilja B Solnes, Paul W Ladenson
OBJECTIVES: Papillary thyroid cancers harboring BRAF (V600E) gene mutation have been shown to exhibit aggressive tumor behaviors and higher risks of recurrence and disease-specific death. In this systematic review and meta-analysis, we examine and report published evidence related to the accuracy of FDG-PET-CT in detection of residual disease in patients' with BRAF (V600E) mutated thyroid cancer. METHODS: We extracted data from PUBMED/MEDLINE and EMBASE from January, 1995 to March, 2017...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142854/skin-metastasis-on-the-neck-an-unusual-presentation-of-recurrence-of-papillary-thyroid-carcinoma
#4
Selen Soylu, Akif Enes Arikan, Serkan Teksoz, Murat Ozcan, Yusuf Bukey
Skin metastasis of papillary thyroid carcinoma (PTC) is rare. Here, two cases of skin metastases of PTC are presented. Both of the patients were females, one is 83 and the other is 65 years old. The patients were admitted to the hospital with a movable skin lesion on anterior neck region. Free T3 and T4 levels were in normal levels and TSH levels were low in both patients. The 83-year-old patient underwent total thyroidectomy due to papillary thyroid cancer and received (131)I ablation therapy and then thyroid suppression therapy...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142850/complications-from-tracheal-resection-for-thyroid-carcinoma
#5
REVIEW
Nicola Rotolo, Maria Cattoni, Andrea Imperatori
Thyroidectomy associated to en bloc tracheal resection with end-to-end anastomosis is the treatment of choice of thyroid tumor invading the tracheal wall and is associated with a good prognosis. However, the postoperative morbidity is not irrelevant. The present review aims to discuss the complications occurring after this aggressive surgical procedure. The search was performed using PubMed through an overarching for the following terms: "complication of tracheal resection [AND] invasive thyroid cancer". Postoperative complications rate after tracheal sleeve resection with end-to-end anastomosis for thyroid cancer invading tracheal wall range from 15% to 39%...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142840/morbidity-of-central-neck-dissection-for-papillary-thyroid-cancer
#6
REVIEW
Davide Lombardi, Remo Accorona, Alberto Paderno, Carlo Cappelli, Piero Nicolai
Thyroid cancer has a very well-known propensity for nodal involvement, either in the central and lateral neck compartments. Neck dissection addressing the central compartment may be performed with an elective or therapeutic intent, the former concomitantly to a thyroidectomy whereas the latter may be accomplished also as a revision procedure for recurrent disease. In this paper complications of central compartment neck dissection will be described, analyzing separately primary and revision procedures.
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29136734/-functional-recovery-after-recurrent-laryngeal-nerve-injury-on-different-electromyography-thresholds-during-thyroid-surgery
#7
X L Liu, C L Li, Y S Zhao, H Sun
Objective: To discuss the functional recovery after recurrent laryngeal nerve injury (RLNI) on different electromyography thresholds during thyroid surgery. Methods: The prospective experimentally were induced in 12 acute recurrent laryngeal traction animals (porcine) from December 2014 to December 2015, the amplitude and latency of electromyography, even time course during RLNI and recovery of 24 recurrent laryngeal nerves(RLN) were continuous intraoperative neuromonitoring(IONM), including 12 RLN releasing traction after 50% amplitude decrease (AD) and other 12 RLN after 70% AD...
November 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29136675/only-a-rapid-complete-biochemical-remission-after-131i-therapy-is-associated-with-an-unimpaired-life-expectancy-in-differentiated-thyroid-cancer
#8
Frederik A Verburg, Uwe Mäder, Inge Grelle, Luca Giovanella, Christoph Reiners, Heribert Hänscheid
The objective of the work was to investigate the relationship between thyroglobulin doubling time (TgDT) as a marker of speed of response to (131)I-therapy and the differentiated thyroid cancer (DTC) recurrence rate, DTC specific mortality rate, and relative survival rate in a DTC population followed over a long period of time after (131)I-therapy. From our database, data of 1354 patients were reviewed. TgDT could be calculated in 174 patients, however, 376 patients did not have sufficient Tg values available for TgDT calculation and 804 patients reached biochemical remission before a sufficient number of Tg measurements for TgDT calculation was acquired...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29130586/prognostic-implication-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-recurrent-papillary-thyroid-cancer
#9
Ji-Hun Kang, Da-Woon Jung, Kyoung-June Pak, In-Ju Kim, Hak-Jin Kim, Jae-Keun Cho, Sung-Chan Shin, Soo-Geun Wang, Byung-Joo Lee
BACKGROUND: Fluorine-18 fluorodeoxyglucose positron emission tomography/CT ((18) F-FDG PET/CT) has been widely accepted as an effective method for detecting recurrent papillary thyroid cancer (PTC) in patients with increased serum thyroglobulin (Tg) or Tg antibody (TgAb) levels and negative whole-body scintigraphy (WBS) results. The role of WBS as a diagnostic tool in detecting recurrence has relatively decreased recently. However, only a few studies have examined the usefulness of (18) F-FDG PET/CT for evaluating patients with recurrent PTC, regardless of the WBS results...
November 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29128176/back-so-soon-is-early-recurrence-of-papillary-thyroid-cancer-really-just-persistent-disease
#10
Maria F Bates, Marcos R Lamas, Reese W Randle, Kristin L Long, Susan C Pitt, David F Schneider, Rebecca S Sippel
BACKGROUND: Papillary thyroid carcinoma has excellent survival, yet recurrence remains a challenge. We sought to determine the proportion of reoperations performed for persistent, rather than truly recurrent, disease. METHODS: We conducted a retrospective review of a prospectively maintained database. Patients with papillary thyroid carcinoma who underwent reoperation for disease from 2000-2016 were included. We defined recurrence as disease that developed after a patient had an undetectable thyroglobulin and a negative ultrasonography within 1 year of operation...
November 8, 2017: Surgery
https://www.readbyqxmd.com/read/29125111/comparison-of-ultrasound-features-of-primary-metastatic-papillary-thyroid-carcinoma-and-recurrent-persistent-metastatic-cervical-lymph-nodes
#11
Jing-Zhu Xu, Zhi-Yong Liang, Xing-Hua Wang, Xiao-Yi Li, Hong-Feng Liu, Qiong Wu, Ru-Yu Liu, Xiao Yang, Shen-Ling Zhu, Rui-Na Zhao, Xing-Jian Lai, Xiao-Yan Zhang, Xue-Hua Xi, Bo Zhang
Objective To explore the ultrasound features and levels of cervical lymph node metastases in primary and recurrent/persistent papillary thyroid cancer (PTC).Methods We retrospectively analyzed the clinical data of 2181 patients who underwent cervical lymph nodes dissection for PTC from January 1(st) 2015 to January 1(st) 2016.Totally 418 PTC patients (with 622 lymph nodes) who met the inclusion criteria entered the final analysis.Patients who had not received any prior thyroid treatment (surgery with or without radioactive iodine) were categorized as the primary group (352 patients with 527 metastatic lymph nodes),and patients who had received prior treatment (thyroidectomy with or without radioactive iodine) for PTC were categorized as recurrent/persistent group (66 patients with 95 metastatic lymph nodes)...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29124480/a-case-of-napsin-a-positive-metastatic-lung-cancer-originating-from-the-colon
#12
Tomokazu Ito, Kozo Nakanishi, Hidenori Goto
BACKGROUND: We report a case of napsin A-positive metastatic lung cancer originating from the colon. No cases of napsin A-positive metastatic lung tumors originating from colorectal cancer have been reported previously. CASE PRESENTATION: Computed tomography identified a small lung nodule in a 70-year-old male patient, 18 months after resection for rectal cancer. The size of the lung tumor increased from 1.8 to 2.1 cm in 6 months and metastasis from the rectal cancer was suspected...
November 9, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29118988/atypical-manifestation-of-parathyroid-carcinoma-with-late-onset-distant-metastases
#13
Marina Tsoli, Anna Angelousi, Dimitra Rontogianni, Constantine Stratakis, Gregory Kaltsas
Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4.5 × 3 × 2.5 cm cystic lesion in the lower pole of the right thyroid lobe that was shown histologically to be a parathyroid carcinoma. Ten years later, the patient developed brain and pulmonary metastases and recurrence of PTH-related hypercalcemia...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29118812/pde5-overexpression-in-well-differentiated-thyroid-carcinomas-is-associated-with-lymph-node-metastasis
#14
Ning Zhang, Zeng Fang, Qiufang Li, Kebing Wang, Songqi Li, Wen Li, Shenming Wang
Overexpression of PDE5 is observed in certain human cancers, but PDE5 expression in well-differentiated thyroid carcinoma (WDTC) is unknown. We therefore examined PDE5 expression and its relationship with the clinicopathological features of WDTC. Real-time qPCR and Western blotting were performed to analyze the expression of PDE5 mRNA and protein in paired WDTC tumor and adjacent nontumor tissues. Immunohistochemistry was used to analyze the expression of PDE5 in paraffin-embedded tissues obtained from 103 cases of WDTC...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29117854/nodal-factors-predictive-of-recurrence-after-thyroidectomy-and-neck-dissection-for-papillary-thyroid-carcinoma
#15
Sung Hoon Nam, Jong-Lyel Roh, Gyungyub Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: The lymph node (LN) yield and ratio are considered important predictors of post-treatment outcomes for several human cancers. This study examined the association between nodal factors including the LN yield and ratio with recurrence after thyroidectomy plus central compartment neck dissection (ND) for papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: This retrospective study involved 2384 consecutive patients who underwent a thyroidectomy plus central compartment ND combined with (n = 440) or without lateral compartment ND at our tertiary referral center between 2006 and 2012...
November 8, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29114601/elective-nodal-dose-of-60%C3%A2-gy-or-50%C3%A2-gy-in-head-and-neck-cancers-a-matched-pair-analysis-of-outcomes-and-toxicity
#16
Vedang Murthy, Lavanya Gurram, Sadhana Kannan, Minakshi Gandhi, Tejpal Gupta, Sarbani Ghosh Laskar, Ashwini Budrukkar, Jai Prakash Agarwal
Purpose: The main objective of this study was to evaluate appropriate doses for elective nodal irradiation (ENI) in head and neck squamous cell carcinoma (HNSCC) patients to optimize the therapeutic ratio. Methods and materials: A matched pair analysis of 2 similar cohorts of HNSCC treated with intensity modulated radiation therapy with different dose prescriptions to the elective nodal regions was conducted. One group received 60 Gy, whereas the other received 50 Gy (ENI60 and ENI50 groups, respectively)...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113646/effects-of-recombinant-canine-interferon-%C3%AE-injected-before-general-anesthesia-with-propofol-and-isoflurane-on-natural-killer-cytotoxic-activity-during-anesthesia-in-dogs
#17
Hirotaka Matsumoto, Takuma Miyata, Tomoko Ohkusa, Takahiro Teshima, Hidekazu Koyama
We aimed to determine whether subcutaneous injection of recombinant canine interferon-γ (rCaIFN-γ) 1h before general anesthesia with a combination of propofol and isoflurane (P-I) changes the cytotoxic activity of natural killer (NK) cells during anesthesia in dogs. Nine clinically healthy beagles were assigned to one of two groups: rCaIFN-γ-treated group (n=5) and control group (no treatment, n=4). One hour before P-I anesthesia, rCaIFN-γ was subcutaneously injected at a dose of 1×10(4)U/kg body weight for the test group and physiologic saline was subcutaneously injected for the control group...
October 26, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29098272/adjuvant-external-beam-radiotherapy-in-locally-advanced-differentiated-thyroid-cancer
#18
Samantha Tam, Moran Amit, Mongkol Boonsripitayanon, Maria E Cabanillas, Naifa L Busaidy, G Brandon Gunn, Stephen Y Lai, Neil D Gross, Erich M Sturgis, Mark E Zafereo
Importance: As incidence of differentiated thyroid cancer rises, treatment paradigms have become increasingly defined. Despite this, locally advanced disease continues to be challenging to manage. Postoperative therapy in the form of radioactive iodine (RAI) is generally recommended, but the role of external beam radiation therapy (EBRT) is less well defined. Objective: To investigate the role of EBRT in locally advanced differentiated thyroid cancer. Design, Setting, and Participants: For this retrospective cohort study, patients treated surgically for T4a differentiated thyroid cancer at the University of Texas MD Anderson Cancer Center from January 2000 through December 2015 were recruited, and 88 patients were included for analysis...
November 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29095280/primary-hypothyroidism-and-isolated-acth-deficiency-induced-by-nivolumab-therapy-case-report-and-review
#19
REVIEW
Mei Fang Zeng, Li Chen, Hong Ying Ye, Wei Gong, Li Nuo Zhou, Yi Ming Li, Xiao Long Zhao
RATIONALE: Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system. PATIENT CONCERNS: A 54-year-old male with renal clear cell carcinoma was treated with nivolumab intravenously. Routine monitoring showed elevated thyroid-stimulating hormone and low free thyroxine after the 6th administration of nivolumab...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29092098/differentiated-and-anaplastic-thyroid-carcinoma-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#20
REVIEW
Nancy D Perrier, James D Brierley, R Michael Tuttle
Answer questions and earn CME/CNE This is a review of the major changes in the American Joint Committee on Cancer staging manual, eighth edition, for differentiated and anaplastic thyroid carcinoma. All patients younger than 55 years have stage I disease unless they have distant metastases, in which case, their disease is stage II. In patients aged 55 years or older, the presence of distant metastases confers stage IVB, while cases without distant metastases are further categorized based on the presence/absence of gross extrathyroidal extension, tumor size, and lymph node status...
November 1, 2017: CA: a Cancer Journal for Clinicians
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