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https://www.readbyqxmd.com/read/28727184/early-warning-systems-and-rapid-response-to-the-deteriorating-patient-in-hospital-a-systematic-realist-review
#1
REVIEW
Jennifer McGaughey, Peter O'Halloran, Sam Porter, Bronagh Blackwood
AIM: To determine the Rapid Response System programme theory and investigate how the mechanisms of implementation and the characteristics of context combine to enable or constrain the implementation of Rapid Response Systems and the achievement of desired outcomes. BACKGROUND: Rapid Response Systems have been implemented internationally to improve the recognition and management of patient deterioration, reduce the need for cardiopulmonary resuscitation and improve patient outcomes...
July 20, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28727019/triennial-growth-and-development-symposium-dedifferentiated-fat-cells-potential-and-perspectives-for-their-use-in-clinical-and-animal-science-purpose
#2
M S Duarte, R Bueno, W Silva, C F Campos, M P Gionbelli, S E F Guimarães, F F Silva, P S Lopes, G J Hausman, M V Dodson
An increasing body of evidences has demonstrated the ability of the mature adipocyte to dedifferentiate into a population of proliferative-competent cells known as dedifferentiated fat (DFAT) cells. As early as the 1970s, in vitro studies showed that DFAT cells may be obtained by ceiling culture, which takes advantage of the buoyancy property of lipid-filled cells. It was documented that DFAT cells may acquire a phenotype similar to mesenchymal stem cells and yet may differentiate into multiple cell lineages, such as skeletal and smooth muscle cells, cardiomyocytes, osteoblasts, and adipocytes...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28724352/a-permutation-based-non-parametric-analysis-of-crispr-screen-data
#3
Gaoxiang Jia, Xinlei Wang, Guanghua Xiao
BACKGROUND: Clustered regularly-interspaced short palindromic repeats (CRISPR) screens are usually implemented in cultured cells to identify genes with critical functions. Although several methods have been developed or adapted to analyze CRISPR screening data, no single specific algorithm has gained popularity. Thus, rigorous procedures are needed to overcome the shortcomings of existing algorithms. METHODS: We developed a Permutation-Based Non-Parametric Analysis (PBNPA) algorithm, which computes p-values at the gene level by permuting sgRNA labels, and thus it avoids restrictive distributional assumptions...
July 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28721501/examining-transgender-health-through-the-international-classification-of-functioning-disability-and-health-s-icf-contextual-factors
#4
REVIEW
Melissa Jacob, Steven R Cox
PURPOSE: For many transgender individuals, medical intervention is necessary to live as their desired gender. However, little is known about Contextual Factors (i.e., Environmental and Personal) that may act as facilitators and barriers in the health of transgender individuals. Therefore, this paper sought to examine Contextual Factors of the World Health Organization's International Classification of Functioning, Disability, and Health that may facilitate or negatively impact the physical, psychological, and social functioning of transgender individuals...
July 18, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28721313/2016-writing-contest-graduate-winner-cardiovascular-disease-training-for-community-health-workers-serving-native-hawaiians-and-other-pacific-peoples
#5
Chace DI Moleta, Mele A Look, Mililani K Trask-Batti, Tricia Mabellos, Marjorie L Mau
To help community health workers (CHW) meet increased demand for their services, it is essential to have data supported strategies for approaches to their training and capacity development. The objective of this paper is to report on the development, implementation, and evaluation of "Heart 101," a cardiovascular disease (CVD) training program, conducted among CHW in Hawai'i who serve Native Hawaiians and other Pacific Peoples (NHPP). Principles from Community-Based Participatory Research provided a framework to develop and implement the 5-hour training curriculum...
July 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28720414/global-health-imaging-in-radiology-residency-a-survey-of-canadian-radiology-residents
#6
Rebecca Zener, Ian Ross
PURPOSE: The study sought to determine Canadian radiology resident perception of and interest in global health imaging (GHI) and the barriers they encounter in pursuing GHI experiences during residency training. METHODS: A peer-reviewed, online, anonymous, multiple-choice survey was distributed to Canadian radiology residents at English-language programs. RESULTS: Fifty residents responded to the survey (∼16% response rate); 72% of respondents perceived an unmet need for medical imaging in the developing world...
July 15, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28719824/supplementation-of-l-carnitine-during-in%C3%A2-vitro-maturation-improves-embryo-development-from-less-competent-bovine-oocytes
#7
Drahomira Knitlova, Pavlina Hulinska, Michal Jeseta, Katerina Hanzalova, Bartosz Kempisty, Marie Machatkova
The present study was designed to define the impact of l-carnitine, supplemented during maturation, on bovine oocytes with different meiotic competence in terms of their IVF outcomes. Meiotically more competent (MMC) and less competent (MLC) oocytes were obtained separately from differently sized follicles at selected phases of folliculogenesis. The oocytes were matured with or without l-carnitine, fertilized and cultured to the blastocyst stage. The oocytes were examined for nuclear maturation, mitochondrial cluster formation, lipid consumption, fertilization and embryo development...
July 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/28719335/experimental-infection-with-and-maintenance-of-cell-fusing-agent-virus-flavivirus-in-aedes-aegypti
#8
Maria Angelica Contreras-Gutierrez, Hilda Guzman, Saravanan Thangamani, Nikos Vasilakis, Robert B Tesh
During the past two decades, there has been a dramatic increase in the recognition and characterization of novel insect-specific flaviviruses (ISFVs). Some of these agents are closely related to important mosquito-borne flavivirus pathogens. Results of experimental studies suggest that mosquitoes and mosquito cell cultures infected with some ISFVs are refractory to superinfection with related flavivirus pathogens; and it has been proposed that ISFVs potentially could be used to alter the vector competence of mosquitoes and reduce transmission of specific flavivirus pathogens, such as dengue, West Nile, or Zika viruses...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718058/cultural-biases-in-current-medical-practices-with-a-specific-attention-to-orthopedic-surgery-a-review
#9
Gracia Etienne, Todd P Pierce, Anton Khlopas, Morad Chughtai, Carlos J Lavernia, Teva Y Vogelstein, Craig M Thomas, Charles S Modlin, Michael A Mont
Due to the increasing diversity within the United States population, there is an ever-increasing need for increased education on cultural literacy and tolerance in medical schools and residency programs. The purpose of this article was to review how a person's culture can play a substantive role in effecting and influencing (1) medical diagnosis, (2) patient and health provider medical decision-making, (3) the patient's perception of disease, and (4) the doctor-patient relationships. Many of the decisions we make as orthopedic surgeons must account for the patient's cultural needs, as much of our work impacts patients' daily activities and function...
July 17, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28717043/tandem-amplification-of-sccmec-can-drive-high-level-methicillin-resistance-in-mrsa
#10
Laura A Gallagher, Simone Coughlan, Nikki S Black, Pierce Lalor, Elaine M Waters, Bryan Wee, Mick Watson, Tim Downing, J Ross Fitzgerald, Gerard T A Fleming, James P O'Gara
Hospital-associated methicillin-resistant Staphylococcus aureus strains typically express high level, homogenous (HoR) β-lactam resistance, whereas community-associated MRSA (CA-MRSA) more commonly express low level heterogeneous (HeR) resistance. Expression of the HoR phenotype typically requires both increased expression of the mecA gene, carried on the Staphylococcus cassette chromosome SCCmec element, and additional mutational event(s) elsewhere on the chromosome. Here the oxacillin concentration in a chemostat culture of the CA-MRSA strain USA300 was increased from 8 μg/ml to 130 μg/ml over 13 days to isolate highly oxacillin resistant derivatives...
July 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28716618/evaluation-of-a-video-based-seminar-to-raise-healthcare-professionals-awareness-of-culturally-sensitive-end-of-life-care
#11
Dulce M Cruz-Oliver, Theodore K Malmstrom, Michael Roegner, Gwen Yeo
OBJECTIVE: To investigate the effect of a newly developed telenovela, or video soap opera, on healthcare professionals (HCP)' awareness of caregivers' stress and patients' cultural approaches to end-of-life (EOL) care decisions. METHODS: A multi-center cross-sectional study among three communities in New York, Miami and Missouri. Participants from a convenience sample of multidisciplinary HCP were randomly assigned to view power point presentation with either a control-video or an intervention-telenovela about caregiving as part of a one- hour audiovisual seminar and completed a pre-posttest questionnaire to evaluate reaction and learning...
July 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28716549/emotional-labour-and-aboriginal-maternal-infant-care-workers-the-invisible-load
#12
R Kirkham, A Rumbold, E Hoon, D Stuart-Butler, V Moore
BACKGROUND: The term 'emotional labour' has been used to describe the competing demands on midwives to empathize with clients whilst maintaining a level of professional detachment. Previous research indicates that when individuals experience difficulty managing these emotions, burnout may result. Aboriginal health care workers often have roles with large emotional demands, as they are relied upon heavily to engage clients in care. However, the concept of emotional labour has received little attention in relation to this group...
July 14, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28716021/missed-diagnoses-in-african-americans-with-obsessive-compulsive-disorder-the-structured-clinical-interview-for-dsm-iv-axis-i-disorders-scid-i
#13
Gregory S Chasson, Monnica T Williams, Darlene M Davis, Jessica Y Combs
BACKGROUND: Research on the utility of structured interviews in assessing OCD is scarce, and even more so, in its use for OCD in African Americans. The purpose of this study was to examine the utility of the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) in detecting OCD in African Americans when used by well-trained, culturally competent clinicians. METHODS: Seventy-four African American adults with OCD were assessed with the SCID-I and additional measures of OCD...
July 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28714707/prospective-relations-between-parent-adolescent-acculturation-conflict-and-mental-health-symptoms-among-vietnamese-american-adolescents
#14
Diem Julie Nguyen, Joanna J Kim, Bahr Weiss, Victoria Ngo, Anna S Lau
OBJECTIVES: Intergenerational acculturation conflict in immigrant families has been implicated as a risk factor for adolescent maladjustment. However, the directionality and specific family related mediators of this association have not been identified. The present study prospectively examined relations between adolescent reports of perceived acculturation conflict and internalizing and externalizing mental health symptoms. Perceived parent-adolescent relationship strain and perceived parental psychological control were examined as potential mediators...
July 17, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28714093/sexual-care-for-patients-receiving-dialysis-a-cross-sectional-study-identifying-the-role-of-nurses-working-in-the-dialysis-department
#15
Gaby F Van Ek, Adina Gawi, Melianthe P J Nicolai, Esmée M Krouwel, Brenda L Den Oudsten, Marjolein E M Den Ouden, Alexander F Schaapherder, Hein Putter, Rob C M Pelger, Henk W Elzevier
AIMS: To explore the role of nurses in the dialysis department in providing sexual care to patients receiving dialysis. BACKGROUND: Sexual health is not self-evident for patients undergoing dialysis; 70% experience sexual dysfunction. Nevertheless, sexual care is often not provided. DESIGN: A national cross-sectional survey. METHODS: Questionnaires (n=171) were sent to employees of 34 dialysis centres from January - May 2016...
July 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28713092/-communicative-competence-and-physician-patient-relationship-in-aboriginal-health-care
#16
Elżbieta Zaniewicz
Modern society consists of people from all walks of life. This melting pot of cultures might be considered both enriching and problematic. In order to communicate successfully, society members should acquire some social skills specific to a given community or, in other words, develop their communicative competence. The aim of this paper is to examine the way extralinguistic knowledge can influence physician - patient relationship in Aboriginal Australian communities. The paper is concerned with not only reviewing fundamental principles of ethnography and communicative competence but also identifying the main cultural differences that may affect the quality of healthcare services...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28712378/treatment-of-allicin-improves-maturation-of-immature-oocytes-and-subsequent-developmental-ability-of-preimplantation-embryos
#17
Sang-Gi Jeong, Seung-Eun Lee, Yun-Gwi Park, Yeo-Jin Son, Min-Young Shin, Eun-Young Kim, Se-Pill Park
Allicin (AL) regulates the cellular redox, proliferation, viability, and cell cycle of different cells against extracellular-derived stress. This study investigated the effects of allicin treatment on porcine oocyte maturation and developmental competence. Porcine oocytes were cultured in medium supplemented with 0 (control), 0.01, 0.1, 1, 10 or 100 μM AL, respectively, during in vitro maturation (IVM). The rate of polar body emission was higher in the 0.1 AL-treated group (74.5% ± 2.3%) than in the control (68...
July 17, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28712352/national-overview-of-medication-assisted-treatment-for-american-indians-and-alaska-natives-with-substance-use-disorders
#18
Traci Rieckmann, Laurie Moore, Calvin Croy, Gregory A Aarons, Douglas K Novins
OBJECTIVE: American Indians and Alaska Natives (AI/ANs) experience higher rates of substance use disorders and less access to high-quality care compared with other racial-ethnic groups. The objective of this study was to better understand the use of medication-assisted treatment (MAT) of substance use disorders for AI/ANs and barriers to broader implementation. METHODS: Representatives of 192 substance abuse treatment programs completed a survey about their use of MAT...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28712347/cultural-competence-a-framework-for-promoting-voluntary-medical-male-circumcision-among-varemba-communities-in-zimbabwe
#19
Kemist Shumba, Musara Lubombo
Almost a decade after the formal introduction of voluntary medical male circumcision (VMMC) as an important technology for HIV prevention, its implementation is still fraught with acceptability challenges. This is especially true among ethnic groups where male circumcision is conducted as a rite of passage into adulthood. In this article we question why VMMC is being met with resistance despite widespread awareness of its promise to reduce HIV incidence in a culturally circumcising community in Zimbabwe. In-depth and key informant interviews were conducted with selected VaRemba initiation graduates and surgeons respectively in Mposi area in Mberengwa to explore why VMMC has not been readily accepted in their community...
July 17, 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28711598/inos-derived-peroxynitrite-mediates-high-glucose-induced-inflammatory-gene-expression-in-vascular-smooth-muscle-cells-through-promoting-klf5-expression-and-nitration
#20
Man-Li Zhang, Bin Zheng, Fei Tong, Zhan Yang, Zhi-Bo Wang, Bao-Ming Yang, Yan Sun, Xin-Hua Zhang, Yi-Lin Zhao, Jin-Kun Wen
Inducible NO synthase (iNOS) expression and peroxynitrite formation are significantly increased in diabetic vascular tissues. Transcription factor KLF5 activates iNOS gene transcription and is involved in vascular inflammatory injury and remodeling. However, mutual regulation between KLF5, iNOS and peroxynitrite in diabetic vascular inflammation, as well as the underlying mechanisms, remain largely unknown. In this study, we found a marked increase in KLF5 and iNOS expression in vascular smooth muscle cells (VSMC) of diabetic patients...
July 12, 2017: Biochimica et Biophysica Acta
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