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Kiran Kumar Vupparaboina, Kunal K Dansingani, Abhilash Goud, Mohammed Abdul Rasheed, Fayez Jawed, Soumya Jana, Ashutosh Richhariya, Bailey K Freund, Jay Chhablani
Conventionally rendered optical coherence tomography (OCT) images of the posterior segment contain shadows which influence the visualization of deep structures such as the choroid. The purpose of this study was to determine whether OCT shadow compensation (SC) alters the appearance of the choroid and the apparent choroidal vascularity index (CVI), an OCT-derived estimated ratio of luminal to total choroidal volume. All scans were shadow compensated using a previously published algorithm, binarized using a novel validated algorithm and extracted binarized choroid to estimate CVI...
April 24, 2018: Scientific Reports
Shao N Khor, Jiang Lei, Jia W Kam, Steven Kum, Yih K Tan, Tjun Y Tang
Objectives This study assessed the effectiveness and patient experience of ClariVein for varicose veins and chronic venous insufficiency (CVI) in a multi-ethnic Asian population from Singapore. Methods A total of 121 patients underwent mechano-chemical ablation. Patients were reviewed at an interval of one week, and at 3, 6 and 12 months post procedure and underwent Duplex ultrasound with patient satisfaction assessment. Results At three months of follow-up, the great saphenous vein and short saphenous vein occlusion rates were 90...
January 1, 2018: Phlebology
A V Chupin, S E Katorkin, I I Katel'nitskiĭ, O V Katel'nitskaia, I I Prostov, A S Petrikov, A P Koshevoĭ, L F Liudkova
INTRODUCTION: Pharmacotherapy occupies one of the leading places in comprehensive treatment of lower-limb chronic venous diseases (CVD) and their complications. At the same time, there are not so many therapeutic agents intended for treatment of CVD and possessing evidence-based efficacy. Sulodexide (registered in Russia as Vessel Due F) is a drug with a confirmed therapeutic effect in patients with a moderately severe course of chronic venous disease or its late stages. However, the experience of using it in Russia for treatment of patients presenting with initial manifestations of chronic venous insufficiency (CVI) is still scarce...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
SeonYoon Chung, Bu Kyung Park, Eun-Shim Nahm
BACKGROUND: In this digital era, eHealth literacy is an essential skill set to leverage health information available online to promote health outcomes. South Korea has an advanced health information technology infrastructure, including widespread use of the internet and mobile phones. A few studies have explored eHealth literacy in South Korea using translated versions of the eHEALS; however, they were not fully validated. A unified reliable and valid assessment tool is critical to assess and enhance the eHealth literacy level across the population...
April 20, 2018: Journal of Medical Internet Research
Patrick M Flanigan, Mitra A Khosravi, James B Leverenz, Babak Tousi
OBJECTIVE: Dementia with Lewy bodies (DLB) is frequently misdiagnosed for Alzheimer dementia (AD), especially in its earlier stages. We characterized color vision impairment (CVI) in patients with DLB versus patients with AD to determine its usefulness in improving accuracy of early diagnosis. METHODS: We retrospectively reviewed charts of patients with AD, DLB, and patients with mild cognitive impairment suspected to be in the prodromal phase of DLB (pro-DLB) or prodromal phase of AD (pro-AD)...
March 2018: Journal of Geriatric Psychiatry and Neurology
Ann Helen Kristoffersen, Per Hyltoft Petersen, Line Bjørge, Thomas Røraas, Sverre Sandberg
BACKGROUND: During pregnancy, interpretation of results from coagulation parameters can be difficult as the physiological changes that occur may affect the biochemical parameters. The aim of this study was to describe the normal course of five coagulation parameters in healthy pregnancies, and to estimate the within-subject biological variation (CVI). METHODS: Blood samples were obtained every 4th week during pregnancy and three samples after delivery in 20 healthy women and every 4th week during a 40-week period in 19 healthy non-pregnant women...
April 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Madiha Sajjad, Rehan Ahmed Khan, Rahila Yasmeen
Objective: To develop a tool to evaluate faculty perceptions of assessment quality in an undergraduate medical program. Methods: The Assessment Implementation Measure (AIM) tool was developed by a mixed method approach. A preliminary questionnaire developed through literature review was submitted to a panel of 10 medical education experts for a three-round 'Modified Delphi technique'. Panel agreement of > 75% was considered the criterion for inclusion of items in the questionnaire...
January 2018: Pakistan Journal of Medical Sciences Quarterly
Xin Wei, Shozo Sonoda, Chitaranjan Mishra, Neha Khandelwal, Ramasamy Kim, Taiji Sakamoto, Rupesh Agrawal
Purpose: To compare the agreement between optical coherence tomography (OCT)-based choroidal vascularity markers measured by two previously reported image binarization techniques. Methods: Spectral-domain OCT using enhanced-depth imaging was performed in 100 eyes from 52 normal subjects. Choroidal images were binarized to luminal area and stromal area using two different algorithms. Choroidal vascularity marker was defined as the ratio of luminal area to total choroidal area and they were termed "luminal/choroidal area ratio (L/C ratio)" and "choroidal vascularity index (CVI)" per the algorithm...
March 1, 2018: Investigative Ophthalmology & Visual Science
Vikas Ambiya, Abhilash Goud, Mohammed Abdul Rasheed, Sankeert Gangakhedkar, Kiran Kumar Vupparaboina, Jay Chhablani
Background: To evaluate the retinal and choroidal alterations in steroid-associated central serous chorioretinopathy (CSC) in comparison to idiopathic CSC. Methods: In this retrospective cohort study, swept source optical coherence tomography scans of eyes with steroid-associated CSC (group A) were compared with the same in idiopathic CSC (group B). The key features included central subfield retinal thickness, subfoveal choroidal thickness, subfoveal large choroidal vessel diameter, subretinal deposits, retinal pigment epithelial irregularities, double layer sign, hyperreflective dots, intraretinal fluid, and choroidal vascularity index (ratio of choroidal luminal area and total choroidal area, measured on a high definition horizontal 9 mm OCT B-scan...
2018: International Journal of Retina and Vitreous
Enas Almanasreh, Rebekah Moles, Timothy F Chen
The assessment of content validity is a critical and complex step in the development process of instruments which are frequently used to measure complex constructs in social and administrative pharmacy research. The aims of this study were to investigate the elements of content validity; to describe a practical approach for assessing content validity; and to discuss existing content validity indices. This is a narrative review of the assessment and quantification of content validity. It describes the key stages of conducting the content validation study and discusses the quantification and evaluation of the content validity estimates...
March 27, 2018: Research in Social & Administrative Pharmacy: RSAP
Abdurrahman Coşkun, Anna Carobene, Meltem Kilercik, Mustafa Serteser, Sverre Sandberg, Aasne K Aarsand, Pilar Fernandez-Calle, Niels Jonker, William A Bartlett, Jorge Díaz-Garzón, Sibel Huet, Cansu Kızıltaş, Ilayda Dalgakıran, Esra Ugur, Ibrahim Unsal
BACKGROUND: The complete blood count (CBC) is used to evaluate health status in the contexts of various clinical situations such as anemia, infection, inflammation, trauma, malignancies, etc. To ensure safe clinical application of the CBC, reliable biological variation (BV) data are required. The study aim was to define the BVs of CBC parameters employing a strict protocol. METHODS: Blood samples, drawn from 30 healthy subjects (17 females, 13 males) once weekly for 10 weeks, were analyzed using a Sysmex XN 3000 instrument...
April 2, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Laurie Newton, Amanda Kotowski, Melissa Grinker, Robert Chun
OBJECTIVES: The aims of this project were two-fold: 1) To assess pediatric primary care (PCP), pediatric otolaryngology (ENT) and pediatric urgent care (UC) providers' perception of their adherence to the 2013 American Academy of Pediatrics (AAP) established guidelines for the diagnosis and management of acute bacterial rhinosinusitis (ABRS) in children 1-18 years old and 2) to assess the same providers' practice patterns in the diagnosis and management of pediatric chronic rhinosinusitis (PCRS)...
May 2018: International Journal of Pediatric Otorhinolaryngology
Jalal Bakhtiyari, Masoomeh Salmani, Reyhaneh Noruzi, Payam Sarraf, Ebrahim Barzegar, Majid Mirmohammadkhani
Introduction: Speech and language therapists (SLTs) require proper tools to detect dysphagia in the early stages. One of these screening tools is the Northwestern Dysphagia Patient Check Sheet (NDPCS). However, this tool needs to be adapted, validated, and shown to be reliable for the Persian culture. The aim of the present study was to report the validity and reliability of the Persian NDPCS (P-NDPCS). Materials and Methods: The NDPCS has 28 items and five sections...
March 2018: Iranian Journal of Otorhinolaryngology
Rajvir Singh, Tulika Mehta Agarwal, Hassan Al-Thani, Yousuf Al Maslamani, Ayman El-Menyar
Objective: To validate a questionnaire for measuring factors influencing organ donation and transplant. Methods: The constructed questionnaire was based on the theory of planned behavior by Ajzen Icek and had 45 questions including general inquiry and demographic information. Four experts on the topic, Arabic culture, and the Arabic and English languages established content validity through review. It was quantified by content validity index (CVI). Construct validity was established by principal component analysis (PCA), whereas internal consistency was checked by Cronbach's Alpha and intraclass correlation coefficient (ICC)...
2018: Journal of Transplantation
Viktoriya Coneva, Daniel H Chitwood
Leaf thickness is a quantitative trait that is associated with the ability of plants to occupy dry, high irradiance environments. Despite its importance, leaf thickness has been difficult to measure reproducibly, which has impeded progress in understanding its genetic basis, and the associated anatomical mechanisms that pattern it. Here, we used a custom-built dual confocal profilometer device to measure leaf thickness in the Arabidopsis Ler × Cvi recombinant inbred line population and found statistical support for four quantitative trait loci (QTL) associated with this trait...
2018: Frontiers in Plant Science
Manita Subedi, Himal Luitel, Bhuminanda Devkota, Rebanta Kumar Bhattarai, Sarita Phuyal, Prabhat Panthi, Anil Shrestha, Dhiraj Kumar Chaudhary
BACKGROUND: Avian pathogenic Escherichia coli (APEC) are causative agent of extraintestinal infections, collectively known as colibacillosis, which results significant losses in poultry industries. The extraintestinal survival of E. coli is facilitated by numerous virulence factors which are coded by virulence genes. This study was conducted to find out the pattern of antibiotic resistance and virulence genes content in the APEC strains isolated from broiler chickens at National Avian Disease Investigation Laboratory and Veterinary Teaching Hospital, Rampur, Chitwan, Nepal...
March 27, 2018: BMC Veterinary Research
Mohammed Abdul Rasheed, Abhilash Goud, Ashik Mohamed, Kiran Kumar Vupparaboina, Jay Chhablani
Purpose: This study aims to compare the effect of laser photocoagulation or observation on choroidal vascularity in acute central serous chorioretinopathy (CSCR). Methods: A retrospective analysis of 30 patients with acute CSCR treated either with laser photocoagulation (16 eyes) or sham laser (14 eyes) was performed. Demographic details, visual acuity (VA) assessment, and other relevant clinical data were considered from baseline to the 3rd and 6th month follow-up visits...
April 2018: Indian Journal of Ophthalmology
Yi Luo, Boxiong Gong, Runtang Meng, Xiaoping Cao, Shuang Tang, Hongzhi Fang, Xing Zhao, Bing Liu
Objective: To translate the Perceived Stress Questionnaire (PSQ) into Chinese, validate its reliability and validity in nursing students and investigate the perceived stress level of nursing students. Method: Forward- and back-translation combined with expert assessment and cross-cultural adaptations were used to construct the Chinese version of the PSQ (C-PSQ). This research adopted a stratified sampling method among 1,519 nursing students in 30 classes of Ningbo College of Health Sciences to assess the reliability and validity of the C-PSQ...
2018: PeerJ
Paloma de Aro J Tavares, Pedro Tadao Hamamoto Filho, Ana Sílvia S Ferreira, Marla Andréia G Ávila
OBJECTIVE: To build and validate a journal-type digital and printed educational material for the informal caregivers of children with hydrocephalus (herein, informal caregivers are defined as the parents who look after the children). METHODS: This is a methodological study conducted in the material unit of the children's neurosurgery outpatient clinic of a university hospital. The content validity index (CVI) with a concordance of 0.78 or greater was used for validation...
March 19, 2018: World Neurosurgery
Haisong Chen, Zheming Wu, Yun Chen, Manshan He, Jiawei Wang
BACKGROUND: To evaluate the changes of choroidal vascular structures in patients after phacoemulsification surgery. METHODS: A self-control study was conducted on 36 eyes of 36 patients who had uneventful phacoemulsification. Choroidal images were acquired preoperatively, 7 days (D7), 1 month (M1), and 3 months (M3) after surgery from enhanced depth imaging (EDI) optical coherence tomography (OCT) scans. Choroidal vascularity index (CVI) was used to assess vascular status of the choroid using image binarization by the Niblack method...
March 23, 2018: BMC Ophthalmology
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