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https://www.readbyqxmd.com/read/28922873/long-term-reduction-of-sacroiliac-joint-pain-with-peripheral-nerve-stimulation
#1
Marin Guentchev, Christian Preuss, Rainer Rink, Levente Peter, Martin H M Sailer, Jochen Tuettenberg
BACKGROUND: We recently demonstrated that 86% of the patients treated with peripheral nerve stimulation (PNS) for therapy-refractory sacroiliac joint (SIJ) pain were satisfied with the result after 1 year of treatment. OBJECTIVE: To investigate the long-term (up to 4 years) response rate of this novel treatment. METHODS: Sixteen consecutive patients with therapy-refractory SIJ pain were treated with PNS and followed for 4 years in 3 patients, 3 years in 6 patients, and 2 years in 1 patient...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922696/does-air-gas-aesthesiometry-generate-a-true-mechanical-stimulus-for-corneal-sensitivity-measurement
#2
Daniela S Nosch, Heiko Pult, Julie Albon, Christine Purslow, Paul J Murphy
BACKGROUND: Belmonte Ocular Pain Meter (OPM) air jet aesthesiometry overcomes some of the limitations of the Cochet-Bonnet aesthesiometer. However, for true mechanical corneal sensitivity measurement, the airflow stimulus temperature of the aesthesiometer must equal ocular surface temperature (OST), to avoid additional response from temperature-sensitive nerves. The aim of this study was to determine: (A) the stimulus temperature inducing no or least change in OST; and (B) to evaluate if OST remains unchanged with different stimulus durations and airflow rates...
September 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28922046/supraorbital-electrical-stimulation-in-management-of-chronic-type-tension-headache-a-randomized-controlled-study
#3
Nashwa S Hamed
BACKGROUND AND PURPOSE: Headache disorders are considered one of the ten most disabling conditions, for both males and females, according to the World Health Organization. Chronic type tension headache (CTTH) has a prevalence of 2-3% within the general population. The purpose of this research was to investigate the effect of stimulating noninvasively the trigeminal nerve in the supraorbital area (SOES) for treatment of CTTH. METHODS: In an 8-week period of intervention, 45 patients were divided equally into three groups...
September 18, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28921418/coping-with-phantom-limb-pain
#4
Damien P Kuffler
Phantom limb pain is a chronic neuropathic pain that develops in 45-85% of patients who undergo major amputations of the upper and lower extremities and appears predominantly during two time frames following an amputation: the first month and later about 1 year. Although in most patients the frequency and intensity of pain diminish over time, severe pain persists in about 5-10%. It has been proposed that factors in both the peripheral and central nervous systems play major roles in triggering the development and maintenance of pain associated with extremity amputations...
September 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28920110/painful-neuropathy-caused-by-compression-of-the-inferior-alveolar-nerve-by-focal-osteosclerotic-lesion-of-the-mandible-a-case-report
#5
David Debevc, Tomaž Hitij, Andrej Kansky
Osteosclerotic lesions are a common finding on dental radiographs. They are considered developmental variants of a normal bone architecture and they usually do not need any treatment. The purpose of this article is to present a rare case of osteosclerotic lesion of the mandible causing trigeminal neuropathy by compression of the alveolar nerve. The pain started with dental hypersensitivity of the mandibular right first molar. Later on, signs of irreversible molar tooth pulpitis developed. Endodontic therapy and apicoectomy did not resolve the pain, which later intensified, and painful neuropathy localized to inferior alveolar nerve developed; therefore, surgical decompression was indicated...
2017: Quintessence International
https://www.readbyqxmd.com/read/28920040/parasympathetic-cholinergic-and-neuropeptide-mechanisms-of-migraine
#6
REVIEW
Nikita Mikhailov, Oleg V Mamontov, Alexei A Kamshilin, Rashid Giniatullin
CONTEXT: Migraine mechanisms remain largely uncovered for various reasons including a very high complexity of the neurophysiological mechanisms implicated in this disorder and a plethora of endogenous biologically active compounds involved in the pathological process. The functional role of parasympathetic innervation of meninges and cholinergic mechanisms of migraine are among little explored issues despite multiple evidence indirectly indicating the role of acetylcholine (ACh) and its analogues in migraine and other types of headache...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28919816/cxcr4-antagonist-amd3100-elicits-analgesic-effect-and-restores-the-glyr%C3%AE-3-expression-against-neuropathic-pain
#7
Xiaoming Liu, Hongjun Liu, Lihua Dai, Bingjie Ma, Ke Ma
OBJECTIVE: Chemokine CXCL12 and its receptor CXCR4 have been reported to play a critical role in neurogenesis and neuronal differentiation. Recently, some reports have implicated this chemokine signaling in the pathogenesis of many kinds of pain. However, its role in neuropathic pain (NP) is still largely unclear. This study explored the distribution and function of CXCR4 in spinal cord (SC) dorsal horn (DH) in a rat L5 spinal nerve ligation (SNL) model. METHODS: Rats received repeated intrathecal injection of CXCR4 antagonist AMD3100...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28919813/a-prospective-double-blinded-randomized-comparison-of-ultrasound-guided-femoral-nerve-block-with-lateral-femoral-cutaneous-nerve-block-versus-standard-anesthetic-management-for-pain-control-during-and-after-traumatic-femur-fracture-repair-in-the-pediatric-population
#8
Nicole M Elsey, Joseph D Tobias, Kevin E Klingele, Ralph J Beltran, Tarun Bhalla, David Martin, Giorgio Veneziano, Julie Rice, Dmitry Tumin
BACKGROUND: Traumatic injury of the femur resulting in femoral fracture may result in significant postoperative pain. As with other causes of acute pain, regional anesthesia may offer a benefit over conventional therapy with intravenous opioids. This study prospectively assesses the effects of femoral nerve blockade with a lateral femoral cutaneous nerve block (FN-LFCN) on intraoperative anesthetic requirements, postoperative pain scores, and opioid requirements. MATERIALS AND METHODS: Seventeen pediatric patients (age 2-18 years) undergoing surgical repair of a traumatic femur fracture fulfilled the study criteria and were randomly assigned to general anesthesia with either an FN-LFCN block (n = 10) or intravenous opioids (n = 7)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28919807/effect-of-nerve-injury-on-the-number-of-dorsal-root-ganglion-neurons-and-autotomy-behavior-in-adult-bax-deficient-mice
#9
Chuang Lyu, Gong-Wei Lyu, Aurora Martinez, Tie-Jun Sten Shi
BACKGROUND: The proapoptotic molecule BAX, plays an important role in mitochondrial apoptotic pathway. Dorsal root ganglion (DRG) neurons depend on neurotrophic factors for survival at early developmental stages. Withdrawal of neurotrophic factors will induce apoptosis in DRG neurons, but this type of cell death can be delayed or prevented in neonatal Bax knockout (KO) mice. In adult animals, evidence also shows that DRG neurons are less dependent upon neurotrophic factors for survival...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28919803/empirical-validation-of-the-horowitz-multiple-systemic-infectious-disease-syndrome-questionnaire-for-suspected-lyme-disease
#10
Maryalice Citera, Phyllis R Freeman, Richard I Horowitz
PURPOSE: Lyme disease is spreading worldwide, with multiple Borrelia species causing a broad range of clinical symptoms that mimic other illnesses. A validated Lyme disease screening questionnaire would be clinically useful for both providers and patients. Three studies evaluated such a screening tool, namely the Horowitz Multiple Systemic Infectious Disease Syndrome (MSIDS) Questionnaire. The purpose was to see if the questionnaire could accurately distinguish between Lyme patients and healthy individuals...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28919502/comparison-of-the-memory-foam-pad-versus-the-bean-bag-with-shoulder-braces-in-preventing-patient-displacement-during-gynecologic-laparoscopic-surgery
#11
Sara Farag, Leigh Rosen, Charles Ascher-Walsh
STUDY OBJECTIVE: The primary aim was to compare the amount of patient displacement when a memory foam pad is used versus a bean bag with shoulder braces. The secondary aim was to evaluate for post-operative extremity symptoms including pain, numbness, and weakness. DESIGN: Prospective randomized pilot study. DESIGN: Classification: Canadian Task Force Class I SETTING: Single academic institution PATIENTS: Women ≥ 18 years of age undergoing laparoscopic or robotic gynecologic surgery INTERVENTIONS: Patients were randomized to be positioned on the memory foam pad (Group A) or the bean bag with shoulder braces (Group B) pre-operatively...
September 15, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28918999/diagnosis-of-ehlers-danlos-syndrome-after-a-first-shoulder-dislocation
#12
Geoffroy Nourissat, Marie Vigan, Claude Hamonet, Levon Doursounian, Julien Deranlot
BACKGROUND: Shoulder dislocation is often the first symptom of Ehlers-Danlos syndrome (EDS). Whether it occurs in early-onset EDS is unknown. In most cases, surgical failure leads to the diagnosis. We aimed to determine whether clinical symptoms can signal the presence of EDS at a first dislocation. MATERIALS AND METHODS: In this retrospective study, we analyzed clinical and radiologic data for 27 patients with EDS and shoulder instability and a control population of 40 consecutive non-EDS patients undergoing surgery for an unstable shoulder...
September 14, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28918661/comparable-postoperative-pain-levels-using-2-different-nerve-blocks-in-the-operative-treatment-of-displaced-intra-articular-calcaneal-fractures
#13
Siem A Dingemans, Kristian J de Ruiter, Merel F N Birnie, J Carel Goslings, Gan van Samkar, Tim Schepers
BACKGROUND: The aim of this study was to compare the postoperative pain levels in patients undergoing osteosynthesis of the calcaneus with either a popliteal nerve block or an ankle block. METHODS: A retrospective analysis of all consecutive patients undergoing operative fixation of a calcaneal fracture via a sinus tarsi approach between August 2012 and April 2017 in a single foot/ankle specialized center was performed. Single-shot popliteal blocks were placed using ultrasound guidance by an anesthesiologist while ankle blocks were placed by a foot/ankle specialized surgeon...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28918572/spot-light-on-skeletal-muscles-optogenetic-stimulation-to-understand-and-restore-skeletal-muscle-function
#14
Tobias van Bremen, Thorsten Send, Philipp Sasse, Tobias Bruegmann
Damage of peripheral nerves results in paralysis of skeletal muscle. Currently, the only treatment option to restore proper function is electrical stimulation of the innervating nerve or of the skeletal muscles directly. However this approach has low spatial and temporal precision leading to co-activation of antagonistic muscles and lacks cell-type selectivity resulting in pain or discomfort by stimulation of sensible nerves. In contrast to electrical stimulation, optogenetic methods enable spatially confined and cell-type selective stimulation of cells expressing the light sensitive channel Channelrhodopsin-2 with precise temporal control over the membrane potential...
September 16, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28915703/treatments-of-traumatic-neuropathic-pain-a-systematic-review
#15
REVIEW
Chenglun Yao, Xijie Zhou, Bin Zhao, Chao Sun, Keshav Poonit, Hede Yan
Traumatic neuropathic pain caused by traumatic neuroma has long been bothering both doctors and patients, the mechanisms of traumatic neuropathic pain are widely discussed by researchers and the treatment is challenging. Clinical treatment of painful neuroma is unclear. Numerous treatment modalities have been introduced by experts in this field. However, there is still no single standard recognized treatment. Different forms of treatments have been tested in animals and humans, but pharmacotherapies (antidepressants, antiepileptics) remain the basis of traumatic neuropathic pain management...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915149/bulleyaconitine-a-preferably-reduces-tetrodotoxin-sensitive-sodium-current-in-uninjured-dorsal-root-ganglion-neurons-of-neuropathic-rats-probably-via-inhibition-of-protein-kinase-c
#16
Man-Xiu Xie, Rui-Ping Pang, Jie Yang, Kai-Feng Shen, Jing Xu, Xiong-Xiong Zhong, Shao-Kun Wang, Xiao-Long Zhang, Yan-Qing Liu, Xian-Guo Liu
Oral Bulleyaconitine A (BLA) is effective for treating neuropathic pain in human patients, but the underlying mechanism is poorly understood. Here, we tested whether BLA blocked voltage-gated sodium channels (VGSCs) in dorsal root ganglion (DRG) neurons. Compelling evidence shows that voltage-gated sodium channels are upregulated in uninjured DRG neurons but downregulated in injured ones following peripheral nerve injury. We found that BLA preferably inhibited Na currents in uninjured DRG neurons in neuropathic rats...
July 17, 2017: Pain
https://www.readbyqxmd.com/read/28914617/distribution-patterns-of-the-vulnerable-vessels-around-cervical-nerve-roots-a-computed-tomography-based-study
#17
Donghwi Park
OBJECTIVE: The aim of the study was to evaluate the prevalence of vulnerable vessels around the target of cervical transforaminal epidural steroid injection at the C3-C7 cervical nerve root levels in a clinical setting. DESIGN: Retrospective, cross-sectional study was conducted. PARTICIPANTS: Patients complaining of neck or arm pain with no previous surgical history and who had undergone both precontrast and contrast-enhanced neck computed tomography were included retrospectively...
September 13, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28914336/patterns-of-cutaneous-nerve-fibre-loss-and-regeneration-in-type-2-diabetes-with-painful-and-painless-polyneuropathy
#18
Gidon J Bönhof, Alexander Strom, Sonja Püttgen, Bernd Ringel, Jutta Brüggemann, Kálmán Bódis, Karsten Müssig, Julia Szendroedi, Michael Roden, Dan Ziegler
AIMS/HYPOTHESIS: The determinants and mechanisms of the development of diabetic sensorimotor polyneuropathy as a painful (DSPN+p) or painless (DSPN-p) entity remain unclear. We examined the degree of cutaneous nerve fibre loss and regeneration in individuals with type 2 diabetes with DSPN+p or DSPN-p compared with individuals with recent-onset type 2 diabetes and corresponding healthy volunteers. METHODS: In this cross-sectional study, skin biopsies taken from the distal lateral calf were obtained from individuals with recent-onset type 2 diabetes (n = 32) from the German Diabetes Study, with DSPN+p (n = 34) and DSPN-p (n = 32) from the PROPANE study, and volunteers with normal glucose tolerance (n = 50)...
September 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28913921/analgesic-efficacy-of-local-infiltration-analgesia-vs-femoral-nerve-block-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-and-meta-analysis
#19
REVIEW
K R Kirkham, S Grape, R Martin, E Albrecht
Many published reports consider blockade of the femoral nerve distribution the best available analgesic treatment after anterior cruciate ligament reconstruction. However, some argue that an alternative approach of infiltrating local anaesthetic into the surgical site has similar efficacy. The objectives of this meta-analysis were to compare the analgesic and functional outcomes of both treatments following anterior ligament reconstruction. The primary outcomes were pain scores at rest (analogue scale, 0-10) in the early (0-2 postoperative hours), intermediate (3-12 hours) and late postoperative periods (13-24 hours)...
September 15, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28913737/minimally-invasive-endoscopic-thyroid-surgery-using-a-collar-access-experience-in-246-cases-with-the-cevits-technique
#20
Franz G Messenbaeck, Michael Weitzendorfer, Cornelia Kaminski, Kai Witzel
BACKGROUND: The arguments for applying minimally invasive techniques are, besides cosmetic results, reduced access trauma and less postoperative pain. In thyroid surgery, cosmetic aspects are gaining importance. Whether minimally invasive endoscopic thyroid surgery is less painful has not been shown yet. METHOD: In this study, we analyse the outcome of 246 patients who underwent cervical endoscopic video-assisted thyroid surgery (CEViTS) regarding the surgery itself, their postoperative pain and satisfaction with the procedure...
September 14, 2017: Surgical Endoscopy
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