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https://www.readbyqxmd.com/read/29652799/combination-kinase-inhibitor-treatment-suppresses-rift-valley-fever-virus-replication
#1
Todd M Bell, Virginia Espina, Lindsay Lundberg, Chelsea Pinkham, Ashwini Brahms, Brian D Carey, Shih-Chao Lin, Bibha Dahal, Caitlin Woodson, Cynthia de la Fuente, Lance A Liotta, Charles L Bailey, Kylene Kehn-Hall
Viruses must parasitize host cell translational machinery in order to make proteins for viral progeny. In this study, we sought to use this signal transduction conduit against them by inhibiting multiple kinases that influence translation. Previous work indicated that several kinases involved in translation, including p70 S6K, p90RSK, ERK, and p38 MAPK, are phosphorylated following Rift Valley fever virus (RVFV) infection. Furthermore, inhibiting p70 S6K through treatment with the FDA approved drug rapamycin prevents RVFV pathogenesis in a mouse model of infection...
April 13, 2018: Viruses
https://www.readbyqxmd.com/read/29650133/contemporary-preoperative-and-intraoperative-management-of-the-radical-cystectomy-patient
#2
REVIEW
Jack Griffin Campbell, Woodson Wade Smelser, Eugene K Lee
Radical cystectomy is a morbid procedure performed on an aging and often frail population. Nonetheless, advances in preoperative and intraoperative management have significantly improved patient outcomes. Preoperative optimization includes a focus on patient education, risk factor reduction, risk stratification, nutritional optimization, and bowel motility enhancement. Intraoperative optimization focuses on maintaining normothermia, restrictive fluid administration, minimization of blood transfusions, and nonopioid pain management...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29615671/local-oceanographic-variability-influences-the-performance-of-juvenile-abalone-under-climate-change
#3
C A Boch, F Micheli, M AlNajjar, S G Monismith, J M Beers, J C Bonilla, A M Espinoza, L Vazquez-Vera, C B Woodson
Climate change is causing warming, deoxygenation, and acidification of the global ocean. However, manifestation of climate change may vary at local scales due to oceanographic conditions. Variation in stressors, such as high temperature and low oxygen, at local scales may lead to variable biological responses and spatial refuges from climate impacts. We conducted outplant experiments at two locations separated by ~2.5 km and two sites at each location separated by ~200 m in the nearshore of Isla Natividad, Mexico to assess how local ocean conditions (warming and hypoxia) may affect juvenile abalone performance...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29582703/upper-airway-stimulation-for-obstructive-sleep-apnea-5-year-outcomes
#4
B Tucker Woodson, Kingman P Strohl, Ryan J Soose, M Boyd Gillespie, Joachim T Maurer, Nico de Vries, Tapan A Padhya, M Safwan Badr, Ho-Sheng Lin, Olivier M Vanderveken, Sam Mickelson, Patrick J Strollo
Objective To present 5-year outcomes from a prospective cohort of patients with obstructive sleep apnea (OSA) who were treated with upper airway stimulation (UAS) via a unilateral hypoglossal nerve implant. Study Design A multicenter prospective cohort study. Setting Industry-supported multicenter academic and clinical trial. Methods From a cohort of 126 patients, 97 completed protocol, and 71 consented to a voluntary polysomnogram. Those having continuous positive airway pressure failure with moderate to severe OSA, body mass index <32 kg/m2 , and no unfavorable collapse on drug-induced sleep endoscopy were enrolled in a phase 3 trial...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29571559/otolaryngology-in-low-resource-settings-practical-and-ethical-considerations
#5
REVIEW
Susan Cordes, Kevin Thomas Robbins, Gayle Woodson
Providing otolaryngology care in low-resource settings requires careful preparation to ensure good outcomes. The level of care that can be provided is dictated by available resources and the supplementary equipment, supplies, and personnel brought in. Other challenges include personal health and safety risks as well as cultural and language differences. Studying outcomes will inform future missions. Educating and developing ongoing partnerships with local physicians can lead to sustained improvements in the local health care system...
March 20, 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29518432/perioperative-immunonutrition-modulates-inflammatory-response-after-radical-cystectomy-results-of-a-pilot-randomized-controlled-clinical-trial
#6
Jill M Hamilton-Reeves, Abigail Stanley, Misty D Bechtel, Thomas M Yankee, Prabhakar Chalise, Lauren K Hand, Eugene K Lee, Woodson Smelser, Moben Mirza, Hadley Wyre, Holly Hull, Susan E Carlson, Jeffrey M Holzbeierlein
PURPOSE: Poor preoperative nutritional status is associated with higher complication rates in bladder cancer patients after radical cystectomy (RC). Given the short lag time between diagnosis and RC, we compared a short-term Specialized IMmunonutrition (SIM) to a standard oral nutrition supplement (ONS) on the acute inflammatory response and arginine status in RC patients. MATERIALS AND METHODS: Twenty-nine men received SIM (n = 14) or ONS (n = 15) to drink three cartons/day for five days before and five days after RC in a prospective, randomized study...
March 5, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29507088/the-pseudomonas-aeruginosa-prrf1-and-prrf2-small-regulatory-rnas-srnas-promote-2-alkyl-4-quinolone-production-through-redundant-regulation-of-the-antr-mrna
#7
Louise Djapgne, Subrata Panja, Luke Brewer, Jonathan Gans, Maureen A Kane, Sarah A Woodson, Amanda G Oglesby-Sherrouse
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that requires iron for growth and virulence. In low iron conditions, P. aeruginosa transcribes two highly identical (95%) small regulatory RNAs (sRNAs), PrrF1 and PrrF2, which are required for virulence in acute murine lung infection models. The PrrF sRNAs promote the production of 2-akly-4(1 H )-quinolone metabolites (AQs) that mediate a range of biological activities, including quorum sensing and polymicrobial interactions. Here we show that the PrrF1 and PrrF2 sRNAs promote AQ production by redundantly inhibiting translation of antR , which encodes a transcriptional activator of the anthranilate degradation genes...
March 5, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29461292/inhalation-injury-in-the-burned-patient
#8
Guillermo Foncerrada, Derek M Culnan, Karel D Capek, Sagrario González-Trejo, Janos Cambiaso-Daniel, Lee C Woodson, David N Herndon, Celeste C Finnerty, Jong O Lee
Inhalation injury causes a heterogeneous cascade of insults that increase morbidity and mortality among the burn population. Despite major advancements in burn care for the past several decades, there remains a significant burden of disease attributable to inhalation injury. For this reason, effort has been devoted to finding new therapeutic approaches to improve outcomes for patients who sustain inhalation injuries.The three major injury classes are the following: supraglottic, subglottic, and systemic. Treatment options for these three subtypes differ based on the pathophysiologic changes that each one elicits...
February 15, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29401016/taking-innovation-to-scale-in-primary-care-practices-the-functions-of-health-care-extension
#9
Sarah S Ono, Benjamin F Crabtree, Jennifer R Hemler, Bijal A Balasubramanian, Samuel T Edwards, Larry A Green, Arthur Kaufman, Leif I Solberg, William L Miller, Tanisha Tate Woodson, Shannon M Sweeney, Deborah J Cohen
Health care extension is an approach to providing external support to primary care practices with the aim of diffusing innovation. EvidenceNOW was launched to rapidly disseminate and implement evidence-based guidelines for cardiovascular preventive care in the primary care setting. Seven regional grantee cooperatives provided the foundational elements of health care extension-technological and quality improvement support, practice capacity building, and linking with community resources-to more than two hundred primary care practices in each region...
February 2018: Health Affairs
https://www.readbyqxmd.com/read/29383054/self-vs-other-focus-predicting-professionalism-remediation-of-emergency-medicine-residents
#10
Robert E Thaxton, Woodson S Jones, Fred W Hafferty, Carolyn W April, Michael D April
Introduction: Unprofessionalism is a major reason for resident dismissal from training. Because of the high stakes involved, residents and educators alike would benefit from information predicting whether they might experience challenges related to this competency. Our objective was to correlate the outcome of professionalism-related remedial actions during residency with the predictor variable of resident response to a standardized interview question: "Why is Medicine important to you?" Methods: We conducted a professional development quality improvement (QI) initiative to improve resident education and mentorship by achieving a better understanding of each resident's reasons for valuing a career in medicine...
January 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29338291/indications-for-surgical-repair-of-type-1-laryngeal-cleft
#11
Craig E Berzofsky, Tali Lando, Sandra Ettema, Jennifer Nelson, Gayle Woodson
OBJECTIVES: Type 1 laryngeal cleft (T1LC) is a congenital deficiency in the posterior glottis, resulting in a communication between the hypopharynx and glottis. No consensus treatment paradigm exists for timing and criteria for patient selection for surgical repair. Our goal is to assess whether patient characteristics can help predict improvement after surgery. METHODS: After Institutional Review Board exemption, a retrospective chart review was performed for patients undergoing surgery to diagnose a T1LC...
April 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29315191/ultra-long-term-audiometric-outcomes-in-the-treatment-of-vestibular-schwannoma-with-the-middle-cranial-fossa-approach
#12
Joseph P Roche, Erika A Woodson, Marlan R Hansen, Bruce J Gantz
OBJECTIVE: Define the long-term audiometric outcomes of vestibular schwannomas treated using the middle cranial fossa (MCF) approach. STUDY DESIGN: Retrospective records review. SETTING: University-based tertiary referral center. PATIENTS: Patients undergoing treatment of small vestibular schwannomas using the MCF approach. INTERVENTION(S): MCF exposure and treatment of small vestibular schwannomas...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29300779/exosomes-serve-as-novel-modes-of-tick-borne-flavivirus-transmission-from-arthropod-to-human-cells-and-facilitates-dissemination-of-viral-rna-and-proteins-to-the-vertebrate-neuronal-cells
#13
Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B Sherman, Kyung H Choi, Girish Neelakanta, Hameeda Sultana
Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Our study shows that tick-borne Langat virus (LGTV), a model pathogen closely related to tick-borne encephalitis virus (TBEV), profusely uses arthropod exosomes for transmission of viral RNA and proteins to the human- skin keratinocytes and blood endothelial cells...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29295998/a-unifying-theory-for-top-heavy-ecosystem-structure-in-the-ocean
#14
C Brock Woodson, John R Schramski, Samantha B Joye
Size generally dictates metabolic requirements, trophic level, and consequently, ecosystem structure, where inefficient energy transfer leads to bottom-heavy ecosystem structure and biomass decreases as individual size (or trophic level) increases. However, many animals deviate from simple size-based predictions by either adopting generalist predatory behavior, or feeding lower in the trophic web than predicted from their size. Here we show that generalist predatory behavior and lower trophic feeding at large body size increase overall biomass and shift ecosystems from a bottom-heavy pyramid to a top-heavy hourglass shape, with the most biomass accounted for by the largest animals...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29212367/assessment-of-patient-and-surgical-variables-including-residency-training-level-on-adverse-events-after-ureteroscopy-for-ureteral-stones-a-multivariate-analysis
#15
Carrie Johans, Woodson Smelser, Chelsea DeRoche, Jack Campbell, James Cummings
PURPOSE: With advances in technology, ureteroscopy (URS) is increasingly utilized for the management of urolithiasis. Previous studies have attempted to characterize the post-operative complication and readmission rates relative to the technical difficulty of the procedure. There is limited data exploring the resident level of training and its effect on adverse outcomes in these cases. We review our experience with URS to create a model to predict factors, including resident experience, that affect rates of post-operative complications...
February 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29204588/radiofrequency-ablation-of-the-lateral-palatal-space-for-snoring
#16
B Tucker Woodson, Kent S Tadokoro, Stuart G MacKay
Objective: Pilot study to examine the effect of radiofrequency ablation (RFA) of the lateral palatal fat pad in patients with socially-disruptive snoring. Method: Snoring outcomes and complications were compared between a group of patients with treated with RFA ablation of the lateral soft palate fat pad with or without inferior turbinate reduction (8 patients) and another group undergoing inferior turbinate reduction alone (12 patients). Results: Snoring loudness and bothersomeness improved in the palate but not inferior turbinate group...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29204585/application-of-drug-induced-sleep-endoscopy-in-patients-treated-with-upper-airway-stimulation-therapy
#17
Adrian A Ong, Christopher M Ayers, Eric J Kezirian, B Tucker Woodson, Nico de Vries, Shaun A Nguyen, M Boyd Gillespie
Objective: To determine the level of agreement among experienced operators of candidacy for upper airway stimulation (UAS) based on evaluation of drug-induced sleep endoscopy (DISE). Methods: The trial was designed as a single-blinded cross-sectional study. Four otolaryngologists with extensive DISE experience were given 63 video clips from the STAR trial video library. These videos were graded using the VOTE classification. Percentage agreement and Cohen's κ (for inter-rater reliability) were calculated between pairs of reviewers, assessing palatal complete concentric collapse (CCC) and determining UAS eligibility...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29204583/osa-treatment-history-in-an-upper-airway-stimulation-trial-cohort
#18
Ryan J Soose, Tapan A Padhya, M Boyd Gillespie, Oleg Froymovich, Ho-Sheng Lin, B Tucker Woodson
Objectives: Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial. Methods: Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial. Self-reported history on prior OSA medical therapy was collected at enrollment, including OSA diagnosis date, CPAP start and stop dates, oral appliance trial, and reasons for discontinuation or non-adherence...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29152541/missing-the-mark-a-two-time-point-cohort-study-estimating-intestinal-parasite-prevalence-in-informal-settlements-in-lima-peru
#19
Michael Townsend Cooper, Rapha A Searing, David M Thompson, David Bard, Hélène Carabin, Carlos Gonzales, Carmen Zavala, Kyle Woodson, Monique Naifeh
Objectives: The World Health Organization's (WHO) recommendations list Peru as potentially needing prevention of soil-transmitted helminthiasis (STH). Prevalence of STH varies regionally and remains understudied in the newest informal settlements of the capital city, Lima. The purpose of this study was to evaluate the need for Mass Drug Administration (MDA) of antiparasitic drugs in the newest informal settlements of Lima. The aim of this study was to estimate the season-specific prevalence of STH to determine if these prevalence estimates met the WHO threshold for MDA in 3 informal settlements...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29148815/information-theoretic-approaches-to-atoms-in-molecules-hirshfeld-family-of-partitioning-schemes
#20
Farnaz Heidar-Zadeh, Paul Woodson Ayers, Toon Verstraelen, Ivan Vinogradov, Esteban Vöhringer-Martinez, Patrick Bultinck
Many population analysis methods are based on the precept that molecules should be built from fragments (typically atoms) that maximally resemble the isolated fragment. The resulting molecular building blocks are intuitive (because they maximally resemble well-understood systems) and transferable (because if two molecular fragments both resemble an isolated fragment, they necessarily resemble each other). Information theory is one way to measure the deviation between molecular fragments and their isolated counterparts, and one that lends itself to analysis...
November 17, 2017: Journal of Physical Chemistry. A
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