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https://www.readbyqxmd.com/read/29401016/taking-innovation-to-scale-in-primary-care-practices-the-functions-of-health-care-extension
#1
Sarah S Ono, Benjamin F Crabtree, Jennifer R Hemler, Bijal A Balasubramanian, Samuel T Edwards, Larry A Green, Arthur Kaufman, Leif I Solberg, William L Miller, Tanisha Tate Woodson, Shannon M Sweeney, Deborah J Cohen
Health care extension is an approach to providing external support to primary care practices with the aim of diffusing innovation. EvidenceNOW was launched to rapidly disseminate and implement evidence-based guidelines for cardiovascular preventive care in the primary care setting. Seven regional grantee cooperatives provided the foundational elements of health care extension-technological and quality improvement support, practice capacity building, and linking with community resources-to more than two hundred primary care practices in each region...
February 2018: Health Affairs
https://www.readbyqxmd.com/read/29383054/self-vs-other-focus-predicting-professionalism-remediation-of-emergency-medicine-residents
#2
Robert E Thaxton, Woodson S Jones, Fred W Hafferty, Carolyn W April, Michael D April
Introduction: Unprofessionalism is a major reason for resident dismissal from training. Because of the high stakes involved, residents and educators alike would benefit from information predicting whether they might experience challenges related to this competency. Our objective was to correlate the outcome of professionalism-related remedial actions during residency with the predictor variable of resident response to a standardized interview question: "Why is Medicine important to you?" Methods: We conducted a professional development quality improvement (QI) initiative to improve resident education and mentorship by achieving a better understanding of each resident's reasons for valuing a career in medicine...
January 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29338291/indications-for-surgical-repair-of-type-1-laryngeal-cleft
#3
Craig E Berzofsky, Tali Lando, Sandra Ettema, Jennifer Nelson, Gayle Woodson
OBJECTIVES: Type 1 laryngeal cleft (T1LC) is a congenital deficiency in the posterior glottis, resulting in a communication between the hypopharynx and glottis. No consensus treatment paradigm exists for timing and criteria for patient selection for surgical repair. Our goal is to assess whether patient characteristics can help predict improvement after surgery. METHODS: After Institutional Review Board exemption, a retrospective chart review was performed for patients undergoing surgery to diagnose a T1LC...
January 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29315191/ultra-long-term-audiometric-outcomes-in-the-treatment-of-vestibular-schwannoma-with-the-middle-cranial-fossa-approach
#4
Joseph P Roche, Erika A Woodson, Marlan R Hansen, Bruce J Gantz
OBJECTIVE: Define the long-term audiometric outcomes of vestibular schwannomas treated using the middle cranial fossa (MCF) approach. STUDY DESIGN: Retrospective records review. SETTING: University-based tertiary referral center. PATIENTS: Patients undergoing treatment of small vestibular schwannomas using the MCF approach. INTERVENTION(S): MCF exposure and treatment of small vestibular schwannomas...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29300779/exosomes-serve-as-novel-modes-of-tick-borne-flavivirus-transmission-from-arthropod-to-human-cells-and-facilitates-dissemination-of-viral-rna-and-proteins-to-the-vertebrate-neuronal-cells
#5
Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B Sherman, Kyung H Choi, Girish Neelakanta, Hameeda Sultana
Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Our study shows that tick-borne Langat virus (LGTV), a model pathogen closely related to tick-borne encephalitis virus (TBEV), profusely uses arthropod exosomes for transmission of viral RNA and proteins to the human- skin keratinocytes and blood endothelial cells...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29295998/a-unifying-theory-for-top-heavy-ecosystem-structure-in-the-ocean
#6
C Brock Woodson, John R Schramski, Samantha B Joye
Size generally dictates metabolic requirements, trophic level, and consequently, ecosystem structure, where inefficient energy transfer leads to bottom-heavy ecosystem structure and biomass decreases as individual size (or trophic level) increases. However, many animals deviate from simple size-based predictions by either adopting generalist predatory behavior, or feeding lower in the trophic web than predicted from their size. Here we show that generalist predatory behavior and lower trophic feeding at large body size increase overall biomass and shift ecosystems from a bottom-heavy pyramid to a top-heavy hourglass shape, with the most biomass accounted for by the largest animals...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29212367/assessment-of-patient-and-surgical-variables-including-residency-training-level-on-adverse-events-after-ureteroscopy-for-ureteral-stones-a-multivariate-analysis
#7
Carrie Johans, Woodson Smelser, Chelsea DeRoche, Jack Campbell, James Cummings
Purpose With advances in technology, ureteroscopy is increasingly utilized for the management of urolithiasis. Previous studies have attempted to characterize the post-operative complication and readmission rates relative to the technical difficulty of the procedure. There is limited data exploring resident level of training and its effect on adverse outcomes in these cases. We review our experience with ureteroscopy to create a model to predict factors, including resident experience,that affect rates of post-operative complications Materials and Methods We reviewed ureteroscopies performed at our academic facility from January 2009 to December 2013...
December 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29204588/radiofrequency-ablation-of-the-lateral-palatal-space-for-snoring
#8
B Tucker Woodson, Kent S Tadokoro, Stuart G MacKay
Objective: Pilot study to examine the effect of radiofrequency ablation (RFA) of the lateral palatal fat pad in patients with socially-disruptive snoring. Method: Snoring outcomes and complications were compared between a group of patients with treated with RFA ablation of the lateral soft palate fat pad with or without inferior turbinate reduction (8 patients) and another group undergoing inferior turbinate reduction alone (12 patients). Results: Snoring loudness and bothersomeness improved in the palate but not inferior turbinate group...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29204585/application-of-drug-induced-sleep-endoscopy-in-patients-treated-with-upper-airway-stimulation-therapy
#9
Adrian A Ong, Christopher M Ayers, Eric J Kezirian, B Tucker Woodson, Nico de Vries, Shaun A Nguyen, M Boyd Gillespie
Objective: To determine the level of agreement among experienced operators of candidacy for upper airway stimulation (UAS) based on evaluation of drug-induced sleep endoscopy (DISE). Methods: The trial was designed as a single-blinded cross-sectional study. Four otolaryngologists with extensive DISE experience were given 63 video clips from the STAR trial video library. These videos were graded using the VOTE classification. Percentage agreement and Cohen's κ (for inter-rater reliability) were calculated between pairs of reviewers, assessing palatal complete concentric collapse (CCC) and determining UAS eligibility...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29204583/osa-treatment-history-in-an-upper-airway-stimulation-trial-cohort
#10
Ryan J Soose, Tapan A Padhya, M Boyd Gillespie, Oleg Froymovich, Ho-Sheng Lin, B Tucker Woodson
Objectives: Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial. Methods: Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial. Self-reported history on prior OSA medical therapy was collected at enrollment, including OSA diagnosis date, CPAP start and stop dates, oral appliance trial, and reasons for discontinuation or non-adherence...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29152541/missing-the-mark-a-two-time-point-cohort-study-estimating-intestinal-parasite-prevalence-in-informal-settlements-in-lima-peru
#11
Michael Townsend Cooper, Rapha A Searing, David M Thompson, David Bard, Hélène Carabin, Carlos Gonzales, Carmen Zavala, Kyle Woodson, Monique Naifeh
Objectives: The World Health Organization's (WHO) recommendations list Peru as potentially needing prevention of soil-transmitted helminthiasis (STH). Prevalence of STH varies regionally and remains understudied in the newest informal settlements of the capital city, Lima. The purpose of this study was to evaluate the need for Mass Drug Administration (MDA) of antiparasitic drugs in the newest informal settlements of Lima. The aim of this study was to estimate the season-specific prevalence of STH to determine if these prevalence estimates met the WHO threshold for MDA in 3 informal settlements...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29148815/information-theoretic-approaches-to-atoms-in-molecules-hirshfeld-family-of-partitioning-schemes
#12
Farnaz Heidar-Zadeh, Paul Woodson Ayers, Toon Verstraelen, Ivan Vinogradov, Esteban Vöhringer-Martinez, Patrick Bultinck
Many population analysis methods are based on the precept that molecules should be built from fragments (typically atoms) that maximally resemble the isolated fragment. The resulting molecular building blocks are intuitive (because they maximally resemble well-understood systems) and transferable (because if two molecular fragments both resemble an isolated fragment, they necessarily resemble each other). Information theory is one way to measure the deviation between molecular fragments and their isolated counterparts, and one that lends itself to analysis...
November 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28921495/probing-rna-folding-pathways-by-rna-fingerprinting
#13
Sarah A Woodson
This unit provides protocols for using native polyacrylamide gel electrophoresis to distinguish folding and unfolding conformers of RNA. It is useful for studying conformers that can exchange in a period of minutes or seconds, and that are thus difficult to study by solution-based methods. Conformers that have been separated and immobilized in the gel matrix can be used to study catalytic activity with or without being eluted from the gel. The method can be applied to a wide variety of catalytic RNAs and RNA-protein complexes...
September 18, 2017: Current Protocols in Nucleic Acid Chemistry
https://www.readbyqxmd.com/read/28887451/evolution-of-protein-coupled-rna-dynamics-during-hierarchical-assembly-of-ribosomal-complexes
#14
Sanjaya C Abeysirigunawardena, Hajin Kim, Jonathan Lai, Kaushik Ragunathan, Mollie C Rappé, Zaida Luthey-Schulten, Taekjip Ha, Sarah A Woodson
Assembly of 30S ribosomes involves the hierarchical addition of ribosomal proteins that progressively stabilize the folded 16S rRNA. Here, we use three-color single molecule FRET to show how combinations of ribosomal proteins uS4, uS17 and bS20 in the 16S 5' domain enable the recruitment of protein bS16, the next protein to join the complex. Analysis of real-time bS16 binding events shows that bS16 binds both native and non-native forms of the rRNA. The native rRNA conformation is increasingly favored after bS16 binds, explaining how bS16 drives later steps of 30S assembly...
September 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28844793/utilization-and-outcomes-of-radical-cystectomy-for-high-grade-non-muscle-invasive-bladder-cancer-in-elderly-patients
#15
William P Parker, Woodson Smelser, Eugene K Lee, Elizabeth B Habermann, Prabin Thapa, Harras B Zaid, Igor Frank, Tomas L Griebling, Matthew K Tollefson, R Houston Thompson, Jeffrey M Holzbeierlein, R Jeffrey Karnes, Stephen A Boorjian
BACKGROUND: Radical cystectomy (RC) represents a treatment option for patients with high-grade non-muscle-invasive bladder cancer (HG-NMIBC); however, perioperative morbidity is not insignificant, particularly in elderly patients. We sought to evaluate the associations of age with utilization and outcomes of RC for HG-NMIBC. PATIENTS AND METHODS: Patients with HG-NMIBC diagnosed between 2004 and 2013 were identified in the National Cancer Database and stratified by age: ≤ 60, 61-70, 71-80, and > 80 years...
August 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28826489/acidic-c-terminal-domains-autoregulate-the-rna-chaperone-hfq
#16
Andrew Santiago-Frangos, Jeliazko R Jeliazkov, Jeffrey J Gray, Sarah A Woodson
The RNA chaperone Hfq is an Sm protein that facilitates base pairing between bacterial small RNAs (sRNAs) and mRNAs involved in stress response and pathogenesis. Hfq possesses an intrinsically disordered C-terminal domain (CTD) that may tune the function of the Sm domain in different organisms. In Escherichia coli, the Hfq CTD increases kinetic competition between sRNAs and recycles Hfq from the sRNA-mRNA duplex. Here, de novo Rosetta modeling and competitive binding experiments show that the acidic tip of the E...
August 9, 2017: ELife
https://www.readbyqxmd.com/read/28825710/metals-induce-transient-folding-and-activation-of-the-twister-ribozyme
#17
Subrata Panja, Boyang Hua, Diego Zegarra, Taekjip Ha, Sarah A Woodson
Twister is a small ribozyme present in almost all kingdoms of life that rapidly self-cleaves in variety of divalent metal ions. We used activity assays, bulk FRET and single-molecule FRET (smFRET) to understand how different metal ions promote folding and self-cleavage of the Oryza sativa twister ribozyme. Although most ribozymes require additional Mg(2+) for catalysis, twister inverts this expectation, requiring 20-30 times less Mg(2+) to self-cleave than to fold. Transition metals such as Co(2+), Ni(2+) and Zn(2+) activate twister more efficiently than Mg(2+) ions...
October 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28810953/continuous-leadership-education-and-development-at-the-san-antonio-uniformed-services-health-education-consortium
#18
Sarah N Bowe, Woodson Scott Jones
No abstract text is available yet for this article.
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28796571/the-fate-and-impact-of-internal-waves-in-nearshore-ecosystems
#19
C B Woodson
Internal waves are widespread features of global oceans that play critical roles in mixing and thermohaline circulation. Similarly to surface waves, internal waves can travel long distances, ultimately breaking along continental margins. These breaking waves can transport deep ocean water and associated constituents (nutrients, larvae, and acidic low-oxygen waters) onto the shelf and locally enhance turbulence and mixing, with important effects on nearshore ecosystems. We are only beginning to understand the role internal waves play in shaping nearshore ecosystems...
August 10, 2017: Annual Review of Marine Science
https://www.readbyqxmd.com/read/28738333/updated-hypopharyngeal-surgery-for-sleep-apnea
#20
B Tucker Woodson
The failure of traditional upper airway surgery such as uvulopalatopharyngoplasty has been attributed to lower airway obstruction related to base of tongue collapse. Multiple procedures, including glossectomy, tongue base radiofrequency, genioglossus advancement, and tongue suspension techniques, have been advocated to improve success rates. No consensus exists on which subsets of patients are best treated by individual approaches and direct comparative data are lacking. The selection of procedures must be based on individual patient needs and the relative potential benefits and risks...
2017: Advances in Oto-rhino-laryngology
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