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https://www.readbyqxmd.com/read/29850893/a-metastable-rrna-junction-essential-for-bacterial-30s-biogenesis
#1
Indra Mani Sharma, Mollie C Rappé, Balasubrahmanyam Addepalli, Wade W Grabow, Zhuoyun Zhuang, Sanjaya C Abeysirigunawardena, Patrick A Limbach, Luc Jaeger, Sarah A Woodson
Tertiary sequence motifs encode interactions between RNA helices that create the three-dimensional structures of ribosomal subunits. A Right Angle motif at the junction between 16S helices 5 and 6 (J5/6) is universally conserved amongst small subunit rRNAs and forms a stable right angle in minimal RNAs. J5/6 does not form a right angle in the mature ribosome, suggesting that this motif encodes a metastable structure needed for ribosome biogenesis. In this study, J5/6 mutations block 30S ribosome assembly and 16S maturation in Escherichia coli...
June 1, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29805741/pilot-study-of-dovitinib-in-patients-with-von-hippel-lindau-disease
#2
Patrick Pilié, Elshad Hasanov, Surena F Matin, Ashley H Henriksen Woodson, Valerie D Marcott, Shelly Bird, Rebecca S Slack, Gregory N Fuller, Ian E McCutcheon, Eric Jonasch
Von Hippel-Lindau (VHL) disease is an autosomal dominant disease occurring in 1 in 35,000 births and leads to an increased risk of a phenotypically diverse array of tumor types including, but not limited to, clear cell renal cell carcinoma (ccRCC) and hemangioblastomas (HBs). Previous studies of patients with VHL disease treated with the tyrosine kinase inhibitor (TKI) sunitinib did not show clinical response in HBs. Interestingly, VHL-related HBs displayed increased fibroblast growth factor receptor 3 (FGFR3) protein expression when compared to VHL-related ccRCCs...
May 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/29802978/military-civilian-partnerships-in-training-sustaining-recruitment-retention-and-readiness-proceedings-from-an-exploratory-first-steps-meeting
#3
M Margaret Knudson, Eric A Elster, Jeffery A Bailey, Jay A Johannigman, Patrick V Bailey, C William Schwab, Garrett G Kirk, Jonathan A Woodson
No abstract text is available yet for this article.
May 23, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29767217/assessing-mentorship-experiences-of-faculty-at-a-military-academic-center-challenge-and-opportunity
#4
Kevin C McMains, Rechell G Rodriguez, Jennifer Peel, Heather C Yun, Mark W True, Woodson S Jones
OBJECTIVES: Mentor relationships are a key component of professional development within academic medicine. To date, there are no investigations into the prevalence and effects of mentor relationships within military academic medicine. This quality improvement initiative aimed to establish the prevalence and effects of mentorship, including whether sex differences exist among faculty at a military academic center, the San Antonio Uniformed Services Health Education Consortium, and identify opportunities to improve faculty development efforts for mentorship to benefit faculty at this institution...
May 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29764978/the-hfq-chaperone-helps-the-ribosome-mature
#5
Indra Mani Sharma, Arthur Korman, Sarah A Woodson
No abstract text is available yet for this article.
May 15, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29762171/hiv-transmission-in-discordant-couples-in-africa-in-the-context-of-art-availability
#6
Evonne Woodson, Alec Goldberg, Clive Michelo, Debby Basu, Sijia Tao, Raymond Schinazi, Yong Jiang, William Kilembe, Etienne Karita, Susan Allen, Eric Hunter
OBJECTIVE: This study aims to understand the basis of continued HIV-1 transmission in Zambian and Rwandan HIV-1 discordant couples in the context of ART. DESIGN: We identified 9 Zambian and 7 Rwandan acutely-infected, epidemiologically-linked couples from government CVCT clinics where transmitting partners reported being on ART near the time of transmission. METHODS: We quantified viral load (VL) and plasma antiretroviral (ARV) drug concentrations near the time of transmission and used these as surrogate measures for adherence...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29752326/genetic-counseling-referral-rates-in-long-term-survivors-of-triple-negative-breast-cancer
#7
Carlos H Barcenas, Maryam N Shafaee, Arup K Sinha, Akshara Raghavendra, Babita Saigal, Rashmi K Murthy, Ashley H Woodson, Banu Arun
Background: Inherited BRCA gene mutations (pathogenic variants) cause 10% of breast cancers. BRCA pathogenic variants predispose carriers to triple-negative breast cancer (TNBC); around 30% of patients with TNBC carry BRCA pathogenic variants. The 2018 NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian recommend genetic counseling referrals for patients with TNBC diagnosed at age ≤60 years. This study sought to describe genetic counseling referral patterns among long-term TNBC survivors at The University of Texas MD Anderson Cancer Center...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29652799/combination-kinase-inhibitor-treatment-suppresses-rift-valley-fever-virus-replication
#8
Todd M Bell, Virginia Espina, Lindsay Lundberg, Chelsea Pinkham, Ashwini Brahms, Brian D Carey, Shih-Chao Lin, Bibha Dahal, Caitlin Woodson, Cynthia de la Fuente, Lance A Liotta, Charles L Bailey, Kylene Kehn-Hall
Viruses must parasitize host cell translational machinery in order to make proteins for viral progeny. In this study, we sought to use this signal transduction conduit against them by inhibiting multiple kinases that influence translation. Previous work indicated that several kinases involved in translation, including p70 S6K, p90RSK, ERK, and p38 MAPK, are phosphorylated following Rift Valley fever virus (RVFV) infection. Furthermore, inhibiting p70 S6K through treatment with the FDA approved drug rapamycin prevents RVFV pathogenesis in a mouse model of infection...
April 13, 2018: Viruses
https://www.readbyqxmd.com/read/29650133/contemporary-preoperative-and-intraoperative-management-of-the-radical-cystectomy-patient
#9
REVIEW
Jack Griffin Campbell, Woodson Wade Smelser, Eugene K Lee
Radical cystectomy is a morbid procedure performed on an aging and often frail population. Nonetheless, advances in preoperative and intraoperative management have significantly improved patient outcomes. Preoperative optimization includes a focus on patient education, risk factor reduction, risk stratification, nutritional optimization, and bowel motility enhancement. Intraoperative optimization focuses on maintaining normothermia, restrictive fluid administration, minimization of blood transfusions, and nonopioid pain management...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29615671/local-oceanographic-variability-influences-the-performance-of-juvenile-abalone-under-climate-change
#10
C A Boch, F Micheli, M AlNajjar, S G Monismith, J M Beers, J C Bonilla, A M Espinoza, L Vazquez-Vera, C B Woodson
Climate change is causing warming, deoxygenation, and acidification of the global ocean. However, manifestation of climate change may vary at local scales due to oceanographic conditions. Variation in stressors, such as high temperature and low oxygen, at local scales may lead to variable biological responses and spatial refuges from climate impacts. We conducted outplant experiments at two locations separated by ~2.5 km and two sites at each location separated by ~200 m in the nearshore of Isla Natividad, Mexico to assess how local ocean conditions (warming and hypoxia) may affect juvenile abalone performance...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29582703/upper-airway-stimulation-for-obstructive-sleep-apnea-5-year-outcomes
#11
B Tucker Woodson, Kingman P Strohl, Ryan J Soose, M Boyd Gillespie, Joachim T Maurer, Nico de Vries, Tapan A Padhya, M Safwan Badr, Ho-Sheng Lin, Olivier M Vanderveken, Sam Mickelson, Patrick J Strollo
Objective To present 5-year outcomes from a prospective cohort of patients with obstructive sleep apnea (OSA) who were treated with upper airway stimulation (UAS) via a unilateral hypoglossal nerve implant. Study Design A multicenter prospective cohort study. Setting Industry-supported multicenter academic and clinical trial. Methods From a cohort of 126 patients, 97 completed protocol, and 71 consented to a voluntary polysomnogram. Those having continuous positive airway pressure failure with moderate to severe OSA, body mass index <32 kg/m2 , and no unfavorable collapse on drug-induced sleep endoscopy were enrolled in a phase 3 trial...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29571559/otolaryngology-in-low-resource-settings-practical-and-ethical-considerations
#12
REVIEW
Susan R Cordes, Kevin Thomas Robbins, Gayle Woodson
Providing otolaryngology care in low-resource settings requires careful preparation to ensure good outcomes. The level of care that can be provided is dictated by available resources and the supplementary equipment, supplies, and personnel brought in. Other challenges include personal health and safety risks as well as cultural and language differences. Studying outcomes will inform future missions. Educating and developing ongoing partnerships with local physicians can lead to sustained improvements in the local health care system...
June 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29518432/perioperative-immunonutrition-modulates-inflammatory-response-after-radical-cystectomy-results-of-a-pilot-randomized-controlled-clinical-trial
#13
Jill M Hamilton-Reeves, Abigail Stanley, Misty D Bechtel, Thomas M Yankee, Prabhakar Chalise, Lauren K Hand, Eugene K Lee, Woodson Smelser, Moben Mirza, Hadley Wyre, Holly Hull, Susan E Carlson, Jeffrey M Holzbeierlein
PURPOSE: Poor preoperative nutritional status is associated with a higher complication rate after radical cystectomy in patients with bladder cancer. Given the short interval between diagnosis and radical cystectomy, we compared the effect of short-term specialized immunonutrition to that of a standard oral nutritional supplement on the acute inflammatory response and arginine status in patients treated with radical cystectomy. MATERIALS AND METHODS: In this prospective, randomized study in 29 men 14 received specialized immunonutrition and 15 received oral nutritional supplement...
March 6, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29507088/the-pseudomonas-aeruginosa-prrf1-and-prrf2-small-regulatory-rnas-promote-2-alkyl-4-quinolone-production-through-redundant-regulation-of-the-antr-mrna
#14
Louise Djapgne, Subrata Panja, Luke K Brewer, Jonathan H Gans, Maureen A Kane, Sarah A Woodson, Amanda G Oglesby-Sherrouse
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that requires iron for growth and virulence. Under low-iron conditions, P. aeruginosa transcribes two highly identical (95%) small regulatory RNAs (sRNAs), PrrF1 and PrrF2, which are required for virulence in acute murine lung infection models. The PrrF sRNAs promote the production of 2-akyl-4(1 H )-quinolone metabolites (AQs) that mediate a range of biological activities, including quorum sensing and polymicrobial interactions. Here, we show that the PrrF1 and PrrF2 sRNAs promote AQ production by redundantly inhibiting translation of antR , which encodes a transcriptional activator of the anthranilate degradation genes...
May 15, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29461292/inhalation-injury-in-the-burned-patient
#15
Guillermo Foncerrada, Derek M Culnan, Karel D Capek, Sagrario González-Trejo, Janos Cambiaso-Daniel, Lee C Woodson, David N Herndon, Celeste C Finnerty, Jong O Lee
Inhalation injury causes a heterogeneous cascade of insults that increase morbidity and mortality among the burn population. Despite major advancements in burn care for the past several decades, there remains a significant burden of disease attributable to inhalation injury. For this reason, effort has been devoted to finding new therapeutic approaches to improve outcomes for patients who sustain inhalation injuries.The three major injury classes are the following: supraglottic, subglottic, and systemic. Treatment options for these three subtypes differ based on the pathophysiologic changes that each one elicits...
March 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29401016/taking-innovation-to-scale-in-primary-care-practices-the-functions-of-health-care-extension
#16
Sarah S Ono, Benjamin F Crabtree, Jennifer R Hemler, Bijal A Balasubramanian, Samuel T Edwards, Larry A Green, Arthur Kaufman, Leif I Solberg, William L Miller, Tanisha Tate Woodson, Shannon M Sweeney, Deborah J Cohen
Health care extension is an approach to providing external support to primary care practices with the aim of diffusing innovation. EvidenceNOW was launched to rapidly disseminate and implement evidence-based guidelines for cardiovascular preventive care in the primary care setting. Seven regional grantee cooperatives provided the foundational elements of health care extension-technological and quality improvement support, practice capacity building, and linking with community resources-to more than two hundred primary care practices in each region...
February 2018: Health Affairs
https://www.readbyqxmd.com/read/29383054/self-vs-other-focus-predicting-professionalism-remediation-of-emergency-medicine-residents
#17
Robert E Thaxton, Woodson S Jones, Fred W Hafferty, Carolyn W April, Michael D April
Introduction: Unprofessionalism is a major reason for resident dismissal from training. Because of the high stakes involved, residents and educators alike would benefit from information predicting whether they might experience challenges related to this competency. Our objective was to correlate the outcome of professionalism-related remedial actions during residency with the predictor variable of resident response to a standardized interview question: "Why is Medicine important to you?" Methods: We conducted a professional development quality improvement (QI) initiative to improve resident education and mentorship by achieving a better understanding of each resident's reasons for valuing a career in medicine...
January 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29338291/indications-for-surgical-repair-of-type-1-laryngeal-cleft
#18
Craig E Berzofsky, Tali Lando, Sandra Ettema, Jennifer Nelson, Gayle Woodson
OBJECTIVES: Type 1 laryngeal cleft (T1LC) is a congenital deficiency in the posterior glottis, resulting in a communication between the hypopharynx and glottis. No consensus treatment paradigm exists for timing and criteria for patient selection for surgical repair. Our goal is to assess whether patient characteristics can help predict improvement after surgery. METHODS: After Institutional Review Board exemption, a retrospective chart review was performed for patients undergoing surgery to diagnose a T1LC...
April 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29315191/ultra-long-term-audiometric-outcomes-in-the-treatment-of-vestibular-schwannoma-with-the-middle-cranial-fossa-approach
#19
Joseph P Roche, Erika A Woodson, Marlan R Hansen, Bruce J Gantz
OBJECTIVE: Define the long-term audiometric outcomes of vestibular schwannomas treated using the middle cranial fossa (MCF) approach. STUDY DESIGN: Retrospective records review. SETTING: University-based tertiary referral center. PATIENTS: Patients undergoing treatment of small vestibular schwannomas using the MCF approach. INTERVENTION(S): MCF exposure and treatment of small vestibular schwannomas...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29300779/exosomes-serve-as-novel-modes-of-tick-borne-flavivirus-transmission-from-arthropod-to-human-cells-and-facilitates-dissemination-of-viral-rna-and-proteins-to-the-vertebrate-neuronal-cells
#20
Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B Sherman, Kyung H Choi, Girish Neelakanta, Hameeda Sultana
Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Our study shows that tick-borne Langat virus (LGTV), a model pathogen closely related to tick-borne encephalitis virus (TBEV), profusely uses arthropod exosomes for transmission of viral RNA and proteins to the human- skin keratinocytes and blood endothelial cells...
January 2018: PLoS Pathogens
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