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J J Fagan, J Aswani, J Otiti, V Mushamba, E Liyombo, G Woodson, D Weed, C Zender, K Mannion, J L Netterville, R Wagner, Mark Zafereo
The University of Cape Town Karl Storz Head and Neck Surgery Fellowship is the only head and neck surgery fellowship in Sub-Saharan Africa. This article briefly describes this fellowship and outlines the experience and ongoing collaborative efforts of members of the American Academy of otolaryngology-head and neck surgery with graduates of this program who are now building head and neck surgery programs in East Africa. This educational collaboration avoids many common pitfalls associated with short-term humanitarian outreach and represents a successful model for international collaborative educational efforts with head and neck surgeons in developing countries in Africa...
2016: SpringerPlus
Katherine Koral Green, B Tucker Woodson
Traditional upper airway surgery directly modifies skeletal and soft tissue structures surrounding the airway to treat obstructive sleep apnea (OSA). Upper airway stimulation (UAS) attempts to treat upper airway obstruction and OSA by stimulating the hypoglossal nerve. The Inspire II implant has been approved for clinical UAS. Basic science data support that UAS prevents obstruction and improves airflow. Clinical results demonstrate that UAS improves respiratory sleep metrics and improves both objective and subjective self-reported sleep and quality-of-life outcomes...
October 6, 2016: Otolaryngologic Clinics of North America
Andrew Santiago-Frangos, Kumari Kavita, Daniel J Schu, Susan Gottesman, Sarah A Woodson
The bacterial Sm protein and RNA chaperone Hfq stabilizes small noncoding RNAs (sRNAs) and facilitates their annealing to mRNA targets involved in stress tolerance and virulence. Although an arginine patch on the Sm core is needed for Hfq's RNA chaperone activity, the function of Hfq's intrinsically disordered C-terminal domain (CTD) has remained unclear. Here, we use stopped flow spectroscopy to show that the CTD of Escherichia coli Hfq is not needed to accelerate RNA base pairing but is required for the release of dsRNA...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Eric Adee, Fernando D Hansel, Dorivar A Ruiz Diaz, Keith Janssen
Strip-till has been used at a large scale in east central Kansas as an alternative to earlier planting dates under a no-till system. To determine the effects of planting corn (Zea mays) under previously established strip-tilled fertilized rows, experiments were conducted on an Osage silty clay loam soil in 2006 and 2008 and on a Woodson silt loam soil in 2009, 2010, and 2011 using three different planting distances from the strip-tilled fertilized rows (0, 10, 20, and 38 cm) with a strip-till operation performed between 1 and 73 days before planting...
2016: Frontiers in Plant Science
Clemens Heiser, Erica Thaler, Maurits Boon, Ryan J Soose, B Tucker Woodson
Selective upper airway stimulation has been established as an additional treatment for obstructive sleep apnea (OSA). Essential for the treatment is the precise placement of the cuff electrode for select branches of the hypoglossal nerve, which innervate the protrusors and stiffeners of the tongue. A direct approach to the distal hypoglossal nerve has been established to achieve this goal. For surgeons, detailed knowledge of this anatomy is vital. Another decisive step is the placement of the sensing lead between the intercostal muscles...
September 2016: Laryngoscope
Jesse D Woodson
Contents 36 I. 36 II. 37 III. 37 IV. 38 V. 39 VI. 40 VII. 40 40 References 40 SUMMARY: All organisms require the ability to sense their surroundings and adapt. Such capabilities allow them to thrive in a wide range of habitats. This is especially true for plants, which are sessile and have to be genetically equipped to withstand every change in their environment. Plants and other eukaryotes use their energy-producing organelles (i.e. mitochondria and chloroplasts) as such sensors. In response to a changing cellular or external environment, these organelles can emit 'retrograde' signals that alter gene expression and/or cell physiology...
October 2016: New Phytologist
Michael J Goard, Gerald N Pho, Jonathan Woodson, Mriganka Sur
Mapping specific sensory features to future motor actions is a crucial capability of mammalian nervous systems. We investigated the role of visual (V1), posterior parietal (PPC), and frontal motor (fMC) cortices for sensorimotor mapping in mice during performance of a memory-guided visual discrimination task. Large-scale calcium imaging revealed that V1, PPC, and fMC neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response). Population analyses demonstrated unique encoding of stimulus identity and behavioral choice information across regions, with V1 encoding stimulus, fMC encoding choice even early in the trial, and PPC multiplexing the two variables...
2016: ELife
Woodson S Jones, Stephen C Maturo, Lisa R Hutcherson
No abstract text is available yet for this article.
July 2016: Journal of Graduate Medical Education
Thiago B C da Silva, Cinara O D'Sousa Costa, Alexandre F C Galvão, Larissa M Bomfim, Ana Carolina B da C Rodrigues, Mauricio C S Mota, Alex A Dantas, Tiago R Dos Santos, Milena B P Soares, Daniel P Bezerra
BACKGROUND: Great biodiversity is a highlight of Brazilian flora. In contrast, the therapeutic potentialities of most species used in folk medicine remain unknown. Several of these species are commonly used to treat cancer. In this study, we investigated the cytotoxic activity of 18 plants from 16 families that are found in the northeast region of Brazil. METHODS: The following species were studied: Byrsonima sericea DC. (Malpighiaceae), Cupania impressinervia Acev...
2016: BMC Complementary and Alternative Medicine
Toon Verstraelen, Steven Vandenbrande, Farnaz Heidar-Zadeh, Louis Vanduyfhuys, Veronique Van Speybroeck, Michel Waroquier, Paul W Ayers
Atomic partial charges appear in the Coulomb term of many force-field models and can be derived from electronic structure calculations with a myriad of atoms-in-molecules (AIM) methods. More advanced models have also been proposed, using the distributed nature of the electron cloud and atomic multipoles. In this work, an electrostatic force field is defined through a concise approximation of the electron density, for which the Coulomb interaction is trivially evaluated. This approximate "pro-density" is expanded in a minimal basis of atom-centered s-type Slater density functions, whose parameters are optimized by minimizing the Kullback-Leibler divergence of the pro-density from a reference electron density, e...
August 9, 2016: Journal of Chemical Theory and Computation
Paul Wurzer, Ludwik K Branski, Robert P Clayton, Gabriel Hundeshagen, Abigail A Forbes, Charles D Voigt, Clark R Andersen, Lars-P Kamolz, Lee C Woodson, Oscar E Suman, Celeste C Finnerty, David N Herndon
PURPOSE: The aim of this study was to quantify the effect of propranolol on hemodynamic parameters assessed using the PiCCO system in burned children. METHODS: We analyzed hemodynamic data from patients who were randomized to receive either propranolol (4 mg/kg/day) or placebo (control), which was initiated as a prospective randomized controlled trial. Endpoints were cardiac index (CI), percent predicted heart rate (%HR), mean arterial pressure (MAP), percent predicted stroke volume (%SV), rate pressure product (RPP), cardiac work (CW), systemic vascular resistance index (SVRI), extravascular lung water index (EVLWI), arterial blood gases, events of lactic acidosis, and mortality...
July 1, 2016: Shock
Duncan Kilburn, Reza Behrouzi, Hui-Ting Lee, Krishnarjun Sarkar, Robert M Briber, Sarah A Woodson
Non-coding RNAs must fold into specific structures that are stabilized by metal ions and other co-solutes in the cell's interior. Large crowder molecules such as PEG stabilize a bacterial group I ribozyme so that the RNA folds in low Mg(2+) concentrations typical of the cell's interior. To understand the thermodynamic origins of stabilization by crowder molecules, small angle X-ray scattering was used to measure the folding and helix assembly of a bacterial group I ribozyme at different temperatures and in different MgCl2 and polyethylene glycol (PEG) concentrations...
July 4, 2016: Nucleic Acids Research
Clemens Heiser, Benedikt Hofauer, Luke Lozier, B Tucker Woodson, Thomas Stark
OBJECTIVE/HYPOTHESIS: Selective stimulation of the upper airway is a new therapy for obstructive sleep apnea. The aim of the study was to determine if a selective nerve integrity monitoring (NIM) system could aid in precise placement of the cuff electrode in selective upper-airway stimulation. STUDY DESIGN: Single-center, prospective clinical trial. METHODS: Twenty patients who received a selective upper-airway stimulation system (Inspire Medical Systems, Maple Grove, MN) were implanted by using a NIM system...
June 27, 2016: Laryngoscope
Mary Margaret Knudson, Eric E Elster, Jonathan Woodson, Garrett Kirk, Patricia Turner, David B Hoyt
No abstract text is available yet for this article.
June 2016: Journal of the American College of Surgeons
Duc A Tien, Erika A Woodson, Samantha Anne
OBJECTIVE: The outcomes of 2 patients with cochlear implants (CIs) who underwent adenotonsillectomy (AT) with inadvertent use of monopolar cautery are presented. The safety data regarding monopolar cautery use in CI recipients is also reviewed. STUDY DESIGN: This is a retrospective case series of 2 CI recipients that underwent AT with monopolar cautery and literature review of electrocautery safety in the setting of CI. RESULTS: Two patients with CIs underwent AT with use of monopolar cautery inadvertently by surgeons that do not routinely perform cochlear implants as part of his or her clinical practice...
September 2016: Annals of Otology, Rhinology, and Laryngology
Amy Zheng, Subrata Panja, Sarah A Woodson
The Sm-protein Hfq facilitates interactions between small non-coding RNA (sRNA) and target mRNAs. In enteric Gram-negative bacteria, Hfq is required for sRNA regulation, and hfq deletion results in stress intolerance and reduced virulence. By contrast, the role of Hfq in Gram-positive is less established and varies among species. The RNA binding and RNA annealing activity of Hfq from Escherichia coli, Pseudomonas aeruginosa, Listeria monocytogenes, Bacillus subtilis, and Staphylococcus aureus were compared using minimal RNAs and fluorescence spectroscopy...
June 5, 2016: Journal of Molecular Biology
Ryan M Hulscher, Jen Bohon, Mollie C Rappé, Sayan Gupta, Rhijuta D'Mello, Michael Sullivan, Corie Y Ralston, Mark R Chance, Sarah A Woodson
The assembly of the Escherichia coli ribosome has been widely studied and characterized in vitro. Despite this, ribosome biogenesis in living cells is only partly understood because assembly is coupled with transcription, modification and processing of the pre-ribosomal RNA. We present a method for footprinting and isolating pre-rRNA as it is synthesized in E. coli cells. Pre-rRNA synthesis is synchronized by starvation, followed by nutrient upshift. RNA synthesized during outgrowth is metabolically labeled to facilitate isolation of recent transcripts...
July 1, 2016: Methods: a Companion to Methods in Enzymology
Adrian A Ong, Alexander W Murphey, Shaun A Nguyen, Ryan J Soose, B Tucker Woodson, Olivier M Vanderveken, Nico de Vries, M Boyd Gillespie
OBJECTIVE: To describe upper airway collapse patterns observed on drug-induced sedation endoscopy (DISE) during screening for a clinical trial and to evaluate the impact of collapse patterns found on preoperative DISE on response rates to upper airway stimulation (UAS) therapy. STUDY DESIGN: Retrospective review of an ongoing prospective multi-institutional cohort study. SETTING: Twenty-two participating institutions of the STAR trial. SUBJECTS AND METHOD: In total, 222 subjects were screened with DISE to determine eligibility for an implantable UAS device...
May 2016: Otolaryngology—Head and Neck Surgery
Catherine F Sinclair, Jeffrey M Bumpous, Bryan R Haugen, Andres Chala, Daniel Meltzer, Barbra S Miller, Neil S Tolley, Jennifer J Shin, Gayle Woodson, Gregory W Randolph
This American Head and Neck Society (AHNS) consensus statement discusses the techniques of laryngeal examination for patients undergoing thyroidectomy and parathyroidectomy. It is intended to help guide all clinicians who diagnose or manage adult patients with thyroid disease for whom surgery is indicated, contemplated, or has been performed. This consensus statement concludes that flexible transnasal laryngoscopy is the optimal laryngeal examination technique, with other techniques including laryngeal ultrasound and stroboscopy being useful in selected scenarios...
June 2016: Head & Neck
Laura Nabors, Christina Baker-Phibbs, Kenneth Woodson
Child trauma is a mental health concern and more information is needed about treatment in community mental health settings. This article presents results of a focus group and member checking sessions held with counselors who provided therapy for children experiencing posttraumatic stress disorder in a community-based setting. Results indicated that play and art techniques were commonly used during individual child therapy sessions. Sessions were child-directed and allowed children to review trauma experiences in a "safe" setting with an "expert" guide...
April 2016: Journal of Prevention & Intervention in the Community
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