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https://www.readbyqxmd.com/read/28222093/active-zone-proteins-are-transported-via-distinct-mechanisms-regulated-by-par-1-kinase
#1
Kara R Barber, Julia Tanquary, Keegan Bush, Amanda Shaw, Michael Woodson, Michael Sherman, Yogesh P Wairkar
Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs) and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions...
February 21, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28194999/upper-airway-stimulation-for-obstructive-sleep-apnea
#2
M Boyd Gillespie, Ryan J Soose, B Tucker Woodson, Kingman P Strohl, Joachim T Maurer, Nico de Vries, David L Steward, Jonathan Z Baskin, M Safwan Badr, Ho-Sheng Lin, Tapan A Padhya, Sam Mickelson, W McDowell Anderson, Olivier M Vanderveken, Patrick J Strollo
Objective To assess patient-based outcomes of participants in a large cohort study-the STAR trial (Stimulation Therapy for Apnea Reduction)-48 months after implantation with an upper airway stimulation system for moderate to severe obstructive sleep apnea. Study Design A multicenter prospective cohort study. Setting Industry-supported multicenter academic and clinical setting. Subjects Participants (n = 91) at 48 months from a cohort of 126 implanted participants. Methods A total of 126 participants received an implanted upper airway stimulation system in a prospective phase III trial...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28194707/obituary-a-remembrance-of-francis-m-howard-md-1922-2016
#3
Marlene Woodson-Howard
No abstract text is available yet for this article.
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28191745/comparison-of-sampling-methods-to-recover-germinated-bacillus-anthracis-and-bacillus-thuringiensis-endospores-from-surface-coupons
#4
Tiffany M Mott, Jennifer L Shoe, Melissa Hunter, Amber M Woodson, Kristen A Fritts, Christopher P Klimko, Avery V Quirk, Susan L Welkos, Christopher K Cote
AIMS: In an attempt to devise decontamination methods that are both effective and minimally detrimental to the environment, we evaluated germination-induction as an enhancement to strategies for Bacillus anthracis spore decontamination. To determine an optimal method for the recovery of germinating spores from different matrices it was critical to ensure that the sampling procedures did not negatively impact the viability of the germinating spores possibly confounding the results and downstream analyses of field trial data...
February 12, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28152263/trajectories-of-weight-change-and-predictors-over-18-month-weight-loss-treatment
#5
Yaguang Zheng, Susan M Sereika, Cynthia A Danford, Christopher C Imes, Rachel Woodson Goode, Juliet Mancino, Lora E Burke
BACKGROUND: Obesity research has typically focused on weight change patterns using the whole sample in randomized clinical trials (RCTs), ignoring subsets of individuals with varying weight change trajectories (e.g., continuing to lose, or maintaining weight). The purpose was to explore possible trajectories of weight change and their associated predictors. METHODS: We conducted a secondary analysis of data from two RCTs using standard behavioral treatment for weight loss...
February 2, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28045632/clinical-practice-guideline-update
#6
Seth R Schwartz, Anthony E Magit, Richard M Rosenfeld, Bopanna B Ballachanda, Jesse M Hackell, Helene J Krouse, Claire M Lawlor, Kenneth Lin, Kourosh Parham, David R Stutz, Sandy Walsh, Erika A Woodson, Ken Yanagisawa, Eugene R Cunningham
The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) has published a supplement to this issue of Otolaryngology-Head and Neck Surgery featuring the updated Clinical Practice Guideline: Earwax (Cerumen Impaction). To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 11 recommendations emphasize proper ear hygiene, diagnosis of cerumen impaction, factors that modify management, evaluating the need for intervention, and proper treatment...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28045591/clinical-practice-guideline-update
#7
Seth R Schwartz, Anthony E Magit, Richard M Rosenfeld, Bopanna B Ballachanda, Jesse M Hackell, Helene J Krouse, Claire M Lawlor, Kenneth Lin, Kourosh Parham, David R Stutz, Sandy Walsh, Erika A Woodson, Ken Yanagisawa, Eugene R Cunningham
Objective This update of the 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation cerumen impaction clinical practice guideline provides evidence-based recommendations on managing cerumen impaction. Cerumen impaction is defined as an accumulation of cerumen that causes symptoms, prevents assessment of the ear, or both. Changes from the prior guideline include a consumer added to the development group; new evidence (3 guidelines, 5 systematic reviews, and 6 randomized controlled trials); enhanced information on patient education and counseling; a new algorithm to clarify action statement relationships; expanded action statement profiles to explicitly state quality improvement opportunities, confidence in the evidence, intentional vagueness, and differences of opinion; an enhanced external review process to include public comment and journal peer review; and 3 new key action statements on managing cerumen impaction that focus on primary prevention, contraindicated intervention, and referral and coordination of care...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27974039/transforming-evidence-generation-to-support-health-and-health-care-decisions
#8
Robert M Califf, Melissa A Robb, Andrew B Bindman, Josephine P Briggs, Francis S Collins, Patrick H Conway, Trinka S Coster, Francesca E Cunningham, Nancy De Lew, Karen B DeSalvo, Christine Dymek, Victor J Dzau, Rachael L Fleurence, Richard G Frank, J Michael Gaziano, Petra Kaufmann, Michael Lauer, Peter W Marks, J Michael McGinnis, Chesley Richards, Joe V Selby, David J Shulkin, Jeffrey Shuren, Andrew M Slavitt, Scott R Smith, B Vindell Washington, P Jon White, Janet Woodcock, Jonathan Woodson, Rachel E Sherman
Making better choices about health and health care requires the best possible evidence. Unfortunately, many of the decisions made today in our health care system are not supported by high-quality evidence derived from randomized, controlled trials or well-designed observational studies. But as..
December 15, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27852852/ablation-of-programmed-1-ribosomal-frameshifting-in-venezuelan-equine-encephalitis-virus-results-in-attenuated-neuropathogenicity
#9
Joseph A Kendra, Cynthia de la Fuente, Ashwini Brahms, Caitlin Woodson, Todd M Bell, Bin Chen, Yousuf A Khan, Jonathan L Jacobs, Kylene Kehn-Hall, Jonathan D Dinman
: The alphaviruses Venezuelan equine encephalitis virus (VEEV), eastern equine encephalitis virus (EEEV), and western equine encephalitis virus (WEEV) are arthropod-borne positive-strand RNA viruses that are capable of causing acute and fatal encephalitis in many mammals, including humans. VEEV was weaponized during the Cold War and is recognized as a select agent. Currently, there are no FDA-approved vaccines or therapeutics for these viruses. The spread of VEEV and other members of this family due to climate change-mediated vector range expansion underscores the need for research aimed at developing medical countermeasures...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27802797/giant-cell-tumor-of-the-distal-femur
#10
Mary Kay C Hannah, Emmanuel J Easterling, Cheryl Ann Woodson
A 24-year-old woman presented to a physical therapy clinic reporting a 4-month history of constant left knee pain of insidious onset. In the setting of nonlocalized, nontraumatic chronic knee pain, the physical therapist ordered radiographs, which revealed an osteolytic lesion along the distal anterolateral femur, suggesting a giant cell tumor. The radiologist then recommended computed tomography for better appreciation of the lesion and magnetic resonance imaging to investigate any soft tissue abnormality...
November 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27722069/educational-workshops-with-graduates-of-the-university-of-cape-town-karl-storz-head-and-neck-surgery-fellowship-program-a-model-for-collaboration-in-outreach-to-developing-countries
#11
J J Fagan, J Aswani, J Otiti, V Mushamba, E Liyombo, G Woodson, D Weed, C Zender, K Mannion, J L Netterville, R Wagner, Mark Zafereo
The University of Cape Town Karl Storz Head and Neck Surgery Fellowship is the only head and neck surgery fellowship in Sub-Saharan Africa. This article briefly describes this fellowship and outlines the experience and ongoing collaborative efforts of members of the American Academy of otolaryngology-head and neck surgery with graduates of this program who are now building head and neck surgery programs in East Africa. This educational collaboration avoids many common pitfalls associated with short-term humanitarian outreach and represents a successful model for international collaborative educational efforts with head and neck surgeons in developing countries in Africa...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27720458/upper-airway-stimulation-therapy
#12
REVIEW
Katherine Koral Green, B Tucker Woodson
Traditional upper airway surgery directly modifies skeletal and soft tissue structures surrounding the airway to treat obstructive sleep apnea (OSA). Upper airway stimulation (UAS) attempts to treat upper airway obstruction and OSA by stimulating the hypoglossal nerve. The Inspire II implant has been approved for clinical UAS. Basic science data support that UAS prevents obstruction and improves airflow. Clinical results demonstrate that UAS improves respiratory sleep metrics and improves both objective and subjective self-reported sleep and quality-of-life outcomes...
December 2016: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27681631/c-terminal-domain-of-the-rna-chaperone-hfq-drives-srna-competition-and-release-of-target-rna
#13
Andrew Santiago-Frangos, Kumari Kavita, Daniel J Schu, Susan Gottesman, Sarah A Woodson
The bacterial Sm protein and RNA chaperone Hfq stabilizes small noncoding RNAs (sRNAs) and facilitates their annealing to mRNA targets involved in stress tolerance and virulence. Although an arginine patch on the Sm core is needed for Hfq's RNA chaperone activity, the function of Hfq's intrinsically disordered C-terminal domain (CTD) has remained unclear. Here, we use stopped flow spectroscopy to show that the CTD of Escherichia coli Hfq is not needed to accelerate RNA base pairing but is required for the release of dsRNA...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27588024/corn-response-as-affected-by-planting-distance-from-the-center-of-strip-till-fertilized-rows
#14
Eric Adee, Fernando D Hansel, Dorivar A Ruiz Diaz, Keith Janssen
Strip-till has been used at a large scale in east central Kansas as an alternative to earlier planting dates under a no-till system. To determine the effects of planting corn (Zea mays) under previously established strip-tilled fertilized rows, experiments were conducted on an Osage silty clay loam soil in 2006 and 2008 and on a Woodson silt loam soil in 2009, 2010, and 2011 using three different planting distances from the strip-tilled fertilized rows (0, 10, 20, and 38 cm) with a strip-till operation performed between 1 and 73 days before planting...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27572119/updates-of-operative-techniques-for-upper-airway-stimulation
#15
REVIEW
Clemens Heiser, Erica Thaler, Maurits Boon, Ryan J Soose, B Tucker Woodson
Selective upper airway stimulation has been established as an additional treatment for obstructive sleep apnea (OSA). Essential for the treatment is the precise placement of the cuff electrode for select branches of the hypoglossal nerve, which innervate the protrusors and stiffeners of the tongue. A direct approach to the distal hypoglossal nerve has been established to achieve this goal. For surgeons, detailed knowledge of this anatomy is vital. Another decisive step is the placement of the sensing lead between the intercostal muscles...
September 2016: Laryngoscope
https://www.readbyqxmd.com/read/27533783/chloroplast-quality-control-balancing-energy-production-and-stress
#16
REVIEW
Jesse D Woodson
Contents 36 I. 36 II. 37 III. 37 IV. 38 V. 39 VI. 40 VII. 40 40 References 40 SUMMARY: All organisms require the ability to sense their surroundings and adapt. Such capabilities allow them to thrive in a wide range of habitats. This is especially true for plants, which are sessile and have to be genetically equipped to withstand every change in their environment. Plants and other eukaryotes use their energy-producing organelles (i.e. mitochondria and chloroplasts) as such sensors. In response to a changing cellular or external environment, these organelles can emit 'retrograde' signals that alter gene expression and/or cell physiology...
October 2016: New Phytologist
https://www.readbyqxmd.com/read/27490481/distinct-roles-of-visual-parietal-and-frontal-motor-cortices-in-memory-guided-sensorimotor-decisions
#17
Michael J Goard, Gerald N Pho, Jonathan Woodson, Mriganka Sur
Mapping specific sensory features to future motor actions is a crucial capability of mammalian nervous systems. We investigated the role of visual (V1), posterior parietal (PPC), and frontal motor (fMC) cortices for sensorimotor mapping in mice during performance of a memory-guided visual discrimination task. Large-scale calcium imaging revealed that V1, PPC, and fMC neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response). Population analyses demonstrated unique encoding of stimulus identity and behavioral choice information across regions, with V1 encoding stimulus, fMC encoding choice even early in the trial, and PPC multiplexing the two variables...
2016: ELife
https://www.readbyqxmd.com/read/27413465/get-a-clew-using-clinical-learning-environment-walks-clews-to-optimize-clinical-learning-environments
#18
Woodson S Jones, Stephen C Maturo, Lisa R Hutcherson
No abstract text is available yet for this article.
July 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/27391476/cytotoxic-potential-of-selected-medicinal-plants-in-northeast-brazil
#19
Thiago B C da Silva, Cinara O D'Sousa Costa, Alexandre F C Galv√£o, Larissa M Bomfim, Ana Carolina B da C Rodrigues, Mauricio C S Mota, Alex A Dantas, Tiago R Dos Santos, Milena B P Soares, Daniel P Bezerra
BACKGROUND: Great biodiversity is a highlight of Brazilian flora. In contrast, the therapeutic potentialities of most species used in folk medicine remain unknown. Several of these species are commonly used to treat cancer. In this study, we investigated the cytotoxic activity of 18 plants from 16 families that are found in the northeast region of Brazil. METHODS: The following species were studied: Byrsonima sericea DC. (Malpighiaceae), Cupania impressinervia Acev...
July 8, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27385073/minimal-basis-iterative-stockholder-atoms-in-molecules-for-force-field-development
#20
Toon Verstraelen, Steven Vandenbrande, Farnaz Heidar-Zadeh, Louis Vanduyfhuys, Veronique Van Speybroeck, Michel Waroquier, Paul W Ayers
Atomic partial charges appear in the Coulomb term of many force-field models and can be derived from electronic structure calculations with a myriad of atoms-in-molecules (AIM) methods. More advanced models have also been proposed, using the distributed nature of the electron cloud and atomic multipoles. In this work, an electrostatic force field is defined through a concise approximation of the electron density, for which the Coulomb interaction is trivially evaluated. This approximate "pro-density" is expanded in a minimal basis of atom-centered s-type Slater density functions, whose parameters are optimized by minimizing the Kullback-Leibler divergence of the pro-density from a reference electron density, e...
August 9, 2016: Journal of Chemical Theory and Computation
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