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https://www.readbyqxmd.com/read/29212367/assessment-of-patient-and-surgical-variables-including-residency-training-level-on-adverse-events-after-ureteroscopy-for-ureteral-stones-a-multivariate-analysis
#1
Carrie Johans, Woodson Smelser, Chelsea DeRoche, Jack Campbell, James Cummings
Purpose With advances in technology, ureteroscopy is increasingly utilized for the management of urolithiasis. Previous studies have attempted to characterize the post-operative complication and readmission rates relative to the technical difficulty of the procedure. There is limited data exploring resident level of training and its effect on adverse outcomes in these cases. We review our experience with ureteroscopy to create a model to predict factors, including resident experience,that affect rates of post-operative complications Materials and Methods We reviewed ureteroscopies performed at our academic facility from January 2009 to December 2013...
December 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29204588/radiofrequency-ablation-of-the-lateral-palatal-space-for-snoring
#2
B Tucker Woodson, Kent S Tadokoro, Stuart G MacKay
Objective: Pilot study to examine the effect of radiofrequency ablation (RFA) of the lateral palatal fat pad in patients with socially-disruptive snoring. Method: Snoring outcomes and complications were compared between a group of patients with treated with RFA ablation of the lateral soft palate fat pad with or without inferior turbinate reduction (8 patients) and another group undergoing inferior turbinate reduction alone (12 patients). Results: Snoring loudness and bothersomeness improved in the palate but not inferior turbinate group...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29204585/application-of-drug-induced-sleep-endoscopy-in-patients-treated-with-upper-airway-stimulation-therapy
#3
Adrian A Ong, Christopher M Ayers, Eric J Kezirian, B Tucker Woodson, Nico de Vries, Shaun A Nguyen, M Boyd Gillespie
Objective: To determine the level of agreement among experienced operators of candidacy for upper airway stimulation (UAS) based on evaluation of drug-induced sleep endoscopy (DISE). Methods: The trial was designed as a single-blinded cross-sectional study. Four otolaryngologists with extensive DISE experience were given 63 video clips from the STAR trial video library. These videos were graded using the VOTE classification. Percentage agreement and Cohen's κ (for inter-rater reliability) were calculated between pairs of reviewers, assessing palatal complete concentric collapse (CCC) and determining UAS eligibility...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29204583/osa-treatment-history-in-an-upper-airway-stimulation-trial-cohort
#4
Ryan J Soose, Tapan A Padhya, M Boyd Gillespie, Oleg Froymovich, Ho-Sheng Lin, B Tucker Woodson
Objectives: Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial. Methods: Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial. Self-reported history on prior OSA medical therapy was collected at enrollment, including OSA diagnosis date, CPAP start and stop dates, oral appliance trial, and reasons for discontinuation or non-adherence...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29152541/missing-the-mark-a-two-time-point-cohort-study-estimating-intestinal-parasite-prevalence-in-informal-settlements-in-lima-peru
#5
Michael Townsend Cooper, Rapha A Searing, David M Thompson, David Bard, Hélène Carabin, Carlos Gonzales, Carmen Zavala, Kyle Woodson, Monique Naifeh
Objectives: The World Health Organization's (WHO) recommendations list Peru as potentially needing prevention of soil-transmitted helminthiasis (STH). Prevalence of STH varies regionally and remains understudied in the newest informal settlements of the capital city, Lima. The purpose of this study was to evaluate the need for Mass Drug Administration (MDA) of antiparasitic drugs in the newest informal settlements of Lima. The aim of this study was to estimate the season-specific prevalence of STH to determine if these prevalence estimates met the WHO threshold for MDA in 3 informal settlements...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29148815/information-theoretic-approaches-to-atoms-in-molecules-hirshfeld-family-of-partitioning-schemes
#6
Farnaz Heidar-Zadeh, Paul Woodson Ayers, Toon Verstraelen, Ivan Vinogradov, Esteban Vöhringer-Martinez, Patrick Bultinck
Many population analysis methods are based on the precept that molecules should be built from fragments (typically atoms) that maximally resemble the isolated fragment. The resulting molecular building blocks are intuitive (because they maximally resemble well-understood systems) and transferable (because if two molecular fragments both resemble an isolated fragment, they necessarily resemble each other). Information theory is one way to measure the deviation between molecular fragments and their isolated counterparts, and one that lends itself to analysis...
November 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28921495/probing-rna-folding-pathways-by-rna-fingerprinting
#7
Sarah A Woodson
This unit provides protocols for using native polyacrylamide gel electrophoresis to distinguish folding and unfolding conformers of RNA. It is useful for studying conformers that can exchange in a period of minutes or seconds, and that are thus difficult to study by solution-based methods. Conformers that have been separated and immobilized in the gel matrix can be used to study catalytic activity with or without being eluted from the gel. The method can be applied to a wide variety of catalytic RNAs and RNA-protein complexes...
September 18, 2017: Current Protocols in Nucleic Acid Chemistry
https://www.readbyqxmd.com/read/28887451/evolution-of-protein-coupled-rna-dynamics-during-hierarchical-assembly-of-ribosomal-complexes
#8
Sanjaya C Abeysirigunawardena, Hajin Kim, Jonathan Lai, Kaushik Ragunathan, Mollie C Rappé, Zaida Luthey-Schulten, Taekjip Ha, Sarah A Woodson
Assembly of 30S ribosomes involves the hierarchical addition of ribosomal proteins that progressively stabilize the folded 16S rRNA. Here, we use three-color single molecule FRET to show how combinations of ribosomal proteins uS4, uS17 and bS20 in the 16S 5' domain enable the recruitment of protein bS16, the next protein to join the complex. Analysis of real-time bS16 binding events shows that bS16 binds both native and non-native forms of the rRNA. The native rRNA conformation is increasingly favored after bS16 binds, explaining how bS16 drives later steps of 30S assembly...
September 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28844793/utilization-and-outcomes-of-radical-cystectomy-for-high-grade-non-muscle-invasive-bladder-cancer-in-elderly-patients
#9
William P Parker, Woodson Smelser, Eugene K Lee, Elizabeth B Habermann, Prabin Thapa, Harras B Zaid, Igor Frank, Tomas L Griebling, Matthew K Tollefson, R Houston Thompson, Jeffrey M Holzbeierlein, R Jeffrey Karnes, Stephen A Boorjian
BACKGROUND: Radical cystectomy (RC) represents a treatment option for patients with high-grade non-muscle-invasive bladder cancer (HG-NMIBC); however, perioperative morbidity is not insignificant, particularly in elderly patients. We sought to evaluate the associations of age with utilization and outcomes of RC for HG-NMIBC. PATIENTS AND METHODS: Patients with HG-NMIBC diagnosed between 2004 and 2013 were identified in the National Cancer Database and stratified by age: ≤ 60, 61-70, 71-80, and > 80 years...
August 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28826489/acidic-c-terminal-domains-autoregulate-the-rna-chaperone-hfq
#10
Andrew Santiago-Frangos, Jeliazko R Jeliazkov, Jeffrey J Gray, Sarah A Woodson
The RNA chaperone Hfq is an Sm protein that facilitates base pairing between bacterial small RNAs (sRNAs) and mRNAs involved in stress response and pathogenesis. Hfq possesses an intrinsically disordered C-terminal domain (CTD) that may tune the function of the Sm domain in different organisms. In Escherichia coli, the Hfq CTD increases kinetic competition between sRNAs and recycles Hfq from the sRNA-mRNA duplex. Here, de novo Rosetta modeling and competitive binding experiments show that the acidic tip of the E...
August 9, 2017: ELife
https://www.readbyqxmd.com/read/28825710/metals-induce-transient-folding-and-activation-of-the-twister-ribozyme
#11
Subrata Panja, Boyang Hua, Diego Zegarra, Taekjip Ha, Sarah A Woodson
Twister is a small ribozyme present in almost all kingdoms of life that rapidly self-cleaves in variety of divalent metal ions. We used activity assays, bulk FRET and single-molecule FRET (smFRET) to understand how different metal ions promote folding and self-cleavage of the Oryza sativa twister ribozyme. Although most ribozymes require additional Mg(2+) for catalysis, twister inverts this expectation, requiring 20-30 times less Mg(2+) to self-cleave than to fold. Transition metals such as Co(2+), Ni(2+) and Zn(2+) activate twister more efficiently than Mg(2+) ions...
October 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28810953/continuous-leadership-education-and-development-at-the-san-antonio-uniformed-services-health-education-consortium
#12
Sarah N Bowe, Woodson Scott Jones
No abstract text is available yet for this article.
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28796571/the-fate-and-impact-of-internal-waves-in-nearshore-ecosystems
#13
C B Woodson
Internal waves are widespread features of global oceans that play critical roles in mixing and thermohaline circulation. Similarly to surface waves, internal waves can travel long distances, ultimately breaking along continental margins. These breaking waves can transport deep ocean water and associated constituents (nutrients, larvae, and acidic low-oxygen waters) onto the shelf and locally enhance turbulence and mixing, with important effects on nearshore ecosystems. We are only beginning to understand the role internal waves play in shaping nearshore ecosystems...
August 10, 2017: Annual Review of Marine Science
https://www.readbyqxmd.com/read/28738333/updated-hypopharyngeal-surgery-for-sleep-apnea
#14
B Tucker Woodson
The failure of traditional upper airway surgery such as uvulopalatopharyngoplasty has been attributed to lower airway obstruction related to base of tongue collapse. Multiple procedures, including glossectomy, tongue base radiofrequency, genioglossus advancement, and tongue suspension techniques, have been advocated to improve success rates. No consensus exists on which subsets of patients are best treated by individual approaches and direct comparative data are lacking. The selection of procedures must be based on individual patient needs and the relative potential benefits and risks...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28688564/utility-of-intraoperative-and-postoperative-radiographs-in-pediatric-cochlear-implant-surgery
#15
Samantha Anne, Jose Miguel Juarez, Amber Shaffer, David Eleff, Dennis Kitsko, Sarah Sydlowski, Erika Woodson, David Chi
OBJECTIVE: Routine plain film radiographs are often obtained to confirm proper placement of electrode after pediatric cochlear implant surgery. Objective is to evaluate necessity of routine radiographs in pediatric cochlear implant cases. STUDY DESIGN: Retrospective review. SETTING: Two tertiary care academic centers. SUBJECTS AND METHODS: Review of all children that underwent cochlear implantation from January 2003 thru June 2015...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28683262/untangling-the-neural-circuits-for-sexual-behavior
#16
Jonathan Woodson, Addison Niemeyer, Joseph Bergan
In this issue, Ishii and colleagues identify an anatomically and genetically defined circuit by which a single compound, exocrine gland-secreted peptide-1 (ESP1), enhances reproductive behavior in female mice.
July 5, 2017: Neuron
https://www.readbyqxmd.com/read/28681961/technical-tips-during-implantation-of-selective-upper-airway-stimulation
#17
Clemens Heiser, Erica Thaler, Ryan J Soose, B Tucker Woodson, Maurits Boon
OBJECTIVE: Selective upper airway stimulation is now well-established in the United States and in several European countries, with more than 1,000 patients implanted since U.S. Food and Drug Administration approval in April 2014. The authors herein, all head and neck surgeons, account for approximately one of every five implants completed to date. Several of the authors also provide comprehensive longitudinal care of their patients as dual-specialty sleep medicine physicians. STUDY DESIGN: Multi-center, retrospective clinical analysis...
July 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28632384/finite-field-method-for-nonlinear-optical-property-prediction-using-rational-function-approximants
#18
Anand H G Patel, Ahmed A K Mohammed, Peter A Limacher, Paul W Ayers
The finite field (FF) method is a quick, easy-to-implement tool for the prediction of nonlinear optical properties. Here, we present and explore a novel variant of the FF method, which uses a rational function to fit a molecule's energy with respect to an electric field. Similarly to previous FF methods, factors crucial for the method's accuracy were tuned. These factors include the number of terms in the function, the distribution of fields used to construct the approximation, and the initial field in the approximation...
July 6, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28632078/-less-than-a-vapor-positioning-black-lesbian-women-in-history-teacher-education
#19
Ashley N Woodson
In this article, I discuss the possibilities and implications of centering Black lesbian identities and relationships in history teacher education through a case study with one straight Black woman preservice history teacher named Danitra. Danitra's understanding and navigation of historical research on Black lesbians are discussed in relation to core themes of lesbian historiography and emancipatory historiography. Though the literature on this group is limited, I argue that critical considerations of Black lesbians' interests and experiences help educators to conceive of and teach about history, citizenship, justice, and sexuality in more liberatory ways...
October 2, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28596260/evaluating-the-nccn-clinical-criteria-for-recommending-brca1-and-brca2-genetic-testing-in-patients-with-breast-cancer
#20
Caiqian Cropper, Ashley Woodson, Banu Arun, Carlos Barcenas, Jennifer Litton, Sarah Noblin, Diane Liu, Minjeong Park, Molly Daniels
Background: Mutations in the BRCA1 and BRCA2 genes predispose individuals to a significantly elevated risk for breast and ovarian cancers. Identification of these individuals allows for proper screening, management, and testing of at-risk relatives. NCCN has established clinical criteria for recommending BRCA1/2 testing. Patients and Methods: A retrospective chart review of 1,123 patients with breast cancer was performed to evaluate the positive predictive values (PPVs) of 14 individual criteria for predicting BRCA1/2 mutations...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
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