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Justin Y Su, David E Olson, Stephen I Ting, J Du Bois
A strategy enabled by C-H and alkene amination technologies for synthesizing the aminocyclitol natural product, pactamycin, is disclosed. This work features two disparate approaches for assembling the five-membered ring core of the target, the first of which utilizes acyl anion catalysis and a second involving β-ketoester aerobic hydroxylation. Installation of the C3-N bond, one of three contiguous nitrogen centers, is made possible through Rh-catalyzed allylic C-H amination of a sulfamate ester. Subsequent efforts are presented to introduce the C1,C2 cis-diamino moiety en route to pactamycin, including carbamate-mediated alkene aziridination...
April 30, 2018: Journal of Organic Chemistry
Anushruti Sarvaria, Rafet Basar, Rohtesh S Mehta, Hila Shaim, Muharrem Muftuoglu, Ahmad Khoder, Takuye Sekine, Elif Gokdemir, Kayo Kondo, David Marin, May Daher, Amin M Alousi, Abdullah Alsuliman, Enli Liu, Betul Oran, Amanda Olson, Roy B Jones, Uday Popat, Chitra Hosing, Richard Champlin, Elizabeth J Shpall, Katayoun Rezvani
Cord blood (CB) offers a number of advantages over other sources of hematopoietic stem cells, including a lower rate of chronic graft-versus-host disease (cGVHD) in the presence of increased HLA disparity. Recent research in experimental models of autoimmunity and in patients with autoimmune or alloimmune disorders has identified a functional group of interleukin-10 (IL-10)-producing regulatory B cells (Bregs) that negatively regulate T-cell immune responses. At present, however, there is no consensus on the phenotypic signature of Bregs, and their prevalence and functional characteristics in CB remain unclear...
September 8, 2016: Blood
Takuya Sekine, David Marin, Kai Cao, Li Li, Pramod Mehta, Hila Shaim, Catherine Sobieski, Roy Jones, Betul Oran, Chitra Hosing, Gabriela Rondon, Abdullah Alsuliman, Silke Paust, Borje Andersson, Uday Popat, Partow Kebriaei, Muharrem Muftuoglu, Rafet Basar, Kayo Kondo, Yago Nieto, Nina Shah, Amanda Olson, Amin Alousi, Enli Liu, Anushruti Sarvaria, Simrit Parmar, Darius Armstrong-James, Nobuhiko Imahashi, Jeffrey Molldrem, Richard Champlin, Elizabeth J Shpall, Katayoun Rezvani
The ability of cord blood transplantation (CBT) to prevent relapse depends partly on donor natural killer (NK) cell alloreactivity. NK effector function depends on specific killer-cell immunoglobulin-like receptors (KIR) and HLA interactions. Thus, it is important to identify optimal combinations of KIR-HLA genotypes in donors and recipients that could improve CBT outcome. We studied clinical data, KIR and HLA genotypes, and NK-cell reconstitution in CBT patients (n = 110). Results were validated in an independent cohort (n = 94)...
July 14, 2016: Blood
Rosa Rosnati, Raffaella Iafrate, Eugenia Scabini
There is a paucity of studies aimed at comparing how parents and children in different family structures cope with the challenges posed by the adolescence transition; in particular, there are few studies aimed at comparing adoptive and foster families. In order to partially fill this gap, the principal aims of the present study were to verify whether there are differences in parent-child communication among foster, intercountry adoptive, and biological families according to the adolescents' gender, and to compare the perceptions of parents and adolescents concerning parent-child communication...
February 2007: International Journal of Psychology: Journal International de Psychologie
Ashoka A Maddur, Richard Swanson, Gonzalo Izaguirre, Peter G W Gettins, Steven T Olson
Serpin protein protease inhibitors inactivate their target proteases through a unique mechanism in which a major serpin conformational change, resulting in a 70-Å translocation of the protease from its initial reactive center loop docking site to the opposite pole of the serpin, kinetically traps the acyl-intermediate complex. Although the initial Michaelis and final trapped acyl-intermediate complexes have been well characterized structurally, the intermediate stages involved in this remarkable transformation are not well understood...
November 1, 2013: Journal of Biological Chemistry
Amy Apodaca, Chris M Olson, Jeffrey Bailey, Frank Butler, Brian J Eastridge, Eric Kuncir
BACKGROUND: The following three helicopter-based medical evacuation platforms operate in Southern Afghanistan: the US Army emergency medical technician (basic)-led DUSTOFF, US Air Force paramedic-led PEDRO, and UK physician-led medical emergency response team (MERT). Nearly 90% of battlefield deaths occur in the prehospital phase, comparative outcomes for these en route care platforms are unknown. The objective of this investigation was to characterize the nature of injuries in patients transported by three evacuation platforms...
August 2013: Journal of Trauma and Acute Care Surgery
Melony G King, Urmila Chandran, Sara H Olson, Kitaw Demissie, Shou-En Lu, Niyati Parekh, Elisa V Bandera
Consumption of foods high in sugar promotes insulin production, which has been linked to endometrial carcinogenesis. We evaluated the impact of dietary intake of sugary foods and beverages, as well as added sugar and total sugar on endometrial cancer risk in a population-based case-control study, including 424 cases and 398 controls. Participants completed an interview and food frequency questionnaire, and provided self-recorded waist and hip measurements. Women in the highest quartile of added sugar intake had significantly increased endometrial cancer risk (OR = 1...
July 2013: Cancer Causes & Control: CCC
Melony G King, Sara H Olson, Lisa Paddock, Urmila Chandran, Kitaw Demissie, Shou-En Lu, Niyati Parekh, Lorna Rodriguez-Rodriguez, Elisa V Bandera
BACKGROUND: Ovarian cancer is the deadliest gynecologic cancer in the US. The consumption of refined sugars has increased dramatically over the past few decades, accounting for almost 15% of total energy intake. Yet, there is limited evidence on how sugar consumption affects ovarian cancer risk. METHODS: We evaluated ovarian cancer risk in relation to sugary foods and beverages, and total and added sugar intakes in a population-based case-control study. Cases were women with newly diagnosed epithelial ovarian cancer, older than 21 years, able to speak English or Spanish, and residents of six counties in New Jersey...
February 27, 2013: BMC Cancer
Nicholas D Allan, Kamna Giare-Patel, Merle E Olson
Infection is the leading complication associated with intravascular devices, and these infections develop when a catheter becomes colonized by microorganisms. To combat this issue, medical device manufacturers seek to provide healthcare facilities with antimicrobial medical devices to prevent or reduce the colonization. In order to adequately evaluate these devices, an in vivo model is required to accurately assess the performance of the antimicrobial devices in a clinical setting. The model presented herein was designed to provide a simulation of the subcutaneous tunnel environment to evaluate the ability of an antimicrobial peripherally inserted central catheter (PICC), coated with chlorhexidine based technology, to reduce microbial migration and colonization compared to an uncoated PICC...
2012: Journal of Biomedicine & Biotechnology
Dina Gifkins, Sara H Olson, Lisa Paddock, Melony King, Kitaw Demissie, Shou-En Lu, Ah-Ng Tony Kong, Lorna Rodriguez-Rodriguez, Elisa V Bandera
BACKGROUND: Limiting oxidative stress to the ovarian epithelium has been proposed as a first-line defense against ovarian cancer. Although evidence for an association between individual dietary antioxidant intake and ovarian cancer risk is conflicting, the combined evidence suggests a modest inverse association. Our study aimed to evaluate the association between total antioxidant capacity (TAC) and individual antioxidant intakes (vitamin C, vitamin E, beta-carotene, selenium, lutein, and lycopene) and ovarian cancer risk...
June 1, 2012: BMC Cancer
Dina Gifkins, Sara H Olson, Kitaw Demissie, Shou-En Lu, Ah-Ng Tony Kong, Elisa V Bandera
We evaluated the role of total dietary antioxidant capacity and of individual antioxidants on endometrial cancer risk in a population-based case-control study in New Jersey, including 417 cases and 395 controls. Dietary intake was ascertained using a food-frequency questionnaire (FFQ), and total antioxidant capacity (TAC) intake was estimated using the USDA Oxygen Radical Absorbance Capacity (ORAC) database and the University of Oslo's Antioxidant Food Database (AFD) and FFQ-derived estimates of intake. Odds ratios and 95 % confidence intervals were derived using multivariate logistic regression controlling for major endometrial cancer risk factors...
June 2012: Cancer Causes & Control: CCC
David E Olson, Autumn Maruniak, Sushant Malhotra, Barry M Trost, J Du Bois
Rhodium-catalyzed oxidative cyclization of allylic hydroxylamine-derived sulfamate esters furnishes a novel family of bicyclic aziridines that serve as functional precursors to substituted diamines. Investigations with the N4-Troc form of these heterocycles have led to manifold improvements in reaction performance and scope and have revealed unique differences in the stability and reactivity of such compounds dictated by the choice of N4-protecting group.
July 1, 2011: Organic Letters
Rajiv Kumar, John C Lieske, Maria L Collazo-Clavell, Michael G Sarr, Ellen R Olson, Terri J Vrtiska, Eric J Bergstralh, Xujian Li
BACKGROUND: Hyperoxaluria and increased calcium oxalate stone formation occur after Roux-en-Y gastric bypass (RYGB) surgery for morbid obesity. The etiology of this hyperoxaluria is unknown. We hypothesized that after bariatric surgery, intestinal hyperabsorption of oxalate contributes to increases in plasma oxalate and urinary calcium oxalate supersaturation. METHODS: We prospectively examined oxalate metabolism in 11 morbidly obese subjects before and 6 and 12 months after RYGB (n = 9) and biliopancreatic diversion-duodenal switch (BPD-DS) (n = 2)...
May 2011: Surgery
Urmila Chandran, Elisa V Bandera, Melony G Williams-King, Lisa E Paddock, Lorna Rodriguez-Rodriguez, Shou-En Lu, Shameka Faulkner, Katherine Pulick, Sara H Olson
The evidence for a role of diet on ovarian cancer prevention remains inconclusive. While many studies have evaluated individual foods and food groups, the evaluation of a comprehensive dietary quality index for predicting cancer risk has received little attention. This study investigates the association between the Healthy Eating Index (HEI), which reflects adherence to the current USDA Dietary Guidelines for Americans and ovarian cancer risk in a population-based case-control study in New Jersey. A total of 205 cases and 390 controls completed the Block 98...
April 2011: Cancer Causes & Control: CCC
Mohamed Abdelgadir Adam, Brian R Untch, John A Olson
Parathyroid carcinoma is an indolent but ultimately life-threatening malignancy. Due to the lack of definitive diagnostic markers and overlapping clinical features of benign primary hyperparathyroidism (PHPT), this disease is often misdiagnosed as parathyroid adenoma. Therefore, a high index of suspicion preoperatively and early intraoperative recognition with en bloc surgical resection are crucial for favorable outcome. Owing to the rarity of the disease, little is known about the molecular pathogenesis of parathyroid carcinoma...
2010: Oncologist
Stryder M Meadows, Andrew S Warkman, Matthew C Salanga, Eric M Small, Paul A Krieg
The myocardin family proteins (myocardin, MRTF-A, and MRTF-B) are serum response factor (SRF) cofactors and potent transcription activators. Gene-ablation studies have indicated important developmental functions for myocardin family proteins primarily in regulation of cardiac and smooth muscle development. Using Xenopus genome and cDNA databases, we identified a myocardin-related transcription factor expressed specifically in the skeletal muscle lineage. Synteny and sequence alignments indicate that this gene is the frog orthologue of mouse MASTR [Creemers EE, Sutherland LB, Oh J, Barbosa AC, Olson EN (2006) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR...
February 5, 2008: Proceedings of the National Academy of Sciences of the United States of America
Alan D Woolf, Andrew R Erdman, Lewis S Nelson, E Martin Caravati, Daniel J Cobaugh, Lisa L Booze, Paul M Wax, Anthony S Manoguerra, Elizabeth J Scharman, Kent R Olson, Peter A Chyka, Gwenn Christianson, William G Troutman
A review of U.S. poison center data for 2004 showed over 12,000 exposures to tricyclic antidepressants (TCAs). A guideline that determines the conditions for emergency department referral and prehospital care could potentially optimize patient outcome, avoid unnecessary emergency department visits, reduce healthcare costs, and reduce life disruption for patients and caregivers. An evidence-based expert consensus process was used to create the guideline. Relevant articles were abstracted by a trained physician researcher...
2007: Clinical Toxicology
Thomas R Hefty, Leslie C Olson, Kalyan C Latchamsetty
INTRODUCTION: We report a technique for extending the distal aorta to facilitate the transplantation of en bloc horseshoe kidneys. TECHNICAL CONSIDERATIONS: En bloc horseshoe kidneys can be transplanted by a technique that is analogous to the en bloc transplantation of small pediatric kidneys. However, the horseshoe kidney's isthmus prevents ascent of the kidney, and the fused lower poles stay below the level of the inferior mesenteric artery. Therefore, the distal aorta is behind the isthmus...
February 2007: Urology
Suiping Zhou, John S Olson, Marian Fabian, Mitchell J Weiss, Andrew J Gow
Alpha hemoglobin-stabilizing protein (AHSP) is an erythroid protein that binds free alpha hemoglobin (alphaHb) to maintain its structure and limit its pro-oxidant activity. Prior studies have defined two different alphaHb.AHSP complexes. Binding of AHSP to Fe(II) alphaHb induces an unusual configuration in which the F helix of the globin becomes disordered and the heme ring becomes solvent-exposed. Over time, this intermediate oxidizes to form a stable hemichrome in which the proximal (F8) and distal (E7) histidines are coordinated to the heme iron atom...
October 27, 2006: Journal of Biological Chemistry
Elizabeth J Scharman, Andrew R Erdman, Paul M Wax, Peter A Chyka, E Martin Caravati, Lewis S Nelson, Anthony S Manoguerra, Gwenn Christianson, Kent R Olson, Alan D Woolf, Daniel C Keyes, Lisa L Booze, William G Troutman
In 2003, there were 28,092 human exposures to diphenhydramine reported to poison centers in the US. A related drug, dimenhydrinate, is a less frequent cause of poisonings. Between January 2000 and June 2004, there were 2,534 reported dimenhydrinate ingestions in children less than 6 years of age. An evidence-based expert consensus process was used to create this guideline. Relevant articles were abstracted by a trained physician researcher. The first draft was created by the primary author. The entire panel discussed and refined the guideline before distribution to secondary reviewers for comment...
2006: Clinical Toxicology
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